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Hirsch Harry J HJ Neuropediatric Unit, Shaare Zedek Medical Center, The Hebrew University, Jerusalem, - - 2014
Background: Minipuberty describes transient activation of the hypothalamic-pituitary-gonadal axis occurring during the first few months of life. Hormone levels during minipuberty were described in only a few Prader-Willi syndrome (PWS) infant boys and have not been reported in PWS infant girls. Objectives: To measure gonadotropins and gonadal hormones in PWS ...
Kittaka Setsuaki S Department of Pediatrics, Yamaguchi University Graduate School of Medicine, 1-1-1 Minamikogushi, Ube, Yamaguchi 755-8505, Japan. Electronic address: - - 2014
Human herpesvirus-6 (HHV-6) is a cause of exanthema subitum and, sometimes, of febrile seizures. However, the pathogenesis of febrile seizures associated with HHV-6 infection remains unclear. We investigated serum matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinases-1 (TIMP-1) levels in infants with HHV-6 infection. Serum levels of both MMP-9 and ...
Benki-Nugent Sarah S Departments of *Global Health, and ‡Epidemiology, University of Washington, Seattle WA, USA; §Department of Paediatrics and Child Health, University of Nairobi, Nairobi, - - 2014
Infant HIV-1 infection is associated with impaired neurologic and motor development. Antiretroviral therapy (ART) has the potential to improve developmental outcomes but the relative contributions of pre-ART disease status, growth, treatment regimen, and ART response during infancy are unknown. Kenyan ART-naive infants <5 months old initiated ART and had monthly ...
Beneteau Anne A 1Department of Pediatrics, Centre Hospitalier de Versailles, Le Chesnay, France 2ACTIV, Association Clinique et Thérapeutique Infantile du Val de Marne, Saint Maur les Fossés, France 3GPIP, Pediatric Infectious Disease Group, France 4Clinical Research Center (CRC), Centre Hospitalier Intercommunal de Créteil, Créteil, France 5Department of pediatrics, Centre Hospitalier Intercommunal de Créteil, France 6Department of Microbiology, Hôpital Cochin, Paris, - - 2014
Bacterial meningitis (BM) is a major cause of morbidity and mortality in children. Sporadic cases of S. bovis have been described in neonates and infants. To assess the epidemiologic, clinical and biologic characteristics of these meningitis, we used the French Surveillance Network for BM in children. 227 pediatric wards working ...
Simonato Manuela M Women's and Children's Health Department, University of Padova, 35128, Padova, Italy, - - 2014
Surfactant protein C (SP-C) is deemed as the surfactant protein most specifically expressed in type II alveolar epithelial cells and plays an important role in surfactant function. SP-C turnover in humans and its meaning in the clinical context have never been approached. In this study, we used mass spectrometry to ...
Chellani Harish H Neonatal Division, Department of Pediatrics, Safdarjung Hospital, New Delhi, 110029, India, - - 2014
Gastro-esophageal reflux (GER) is a common occurrence in newborns and a cause of anxiety to most parents. This physiological process needs to be closely differentiated from pathological reflux. The clinical signs in infants are generally non-specific which makes the distinction difficult. The diagnostic options in infants are limited, have low ...
Prahl M M Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, - - 2014
We describe two cases of premature infants who developed clinical and radiologic evidence of gastric lactobezoars within the same month in our neonatal intensive care unit while both were receiving medium-chain triglyceride-rich formula as part of the management of chylothoraces.
Yoon Jung Min JM Department of Pediatrics, Konyang University College of Medicine, Daejeon, - - 2014
Among the many factors associated with acute intestinal mucosal infection, numerous studies have proposed the usefulness of fecal calprotectin. The aim of this study was to evaluate the usefulness of fecal calprotectin in the diagnosis of necrotizing enterocolitis (NEC). We collected 154 stool samples from 16 very low birth weight ...
Bae Hyun Kyung HK Department of Pediatrics, Ewha Womans University School of Medicine, Seoul, - - 2014
The incidence of Kawasaki disease (KD) is rare in young infants (less than 3 months of age), who present with only a few symptoms that fulfill the clinical diagnostic criteria. The diagnosis for KD can therefore be delayed, leading to a high risk of cardiac complications. We examined the clinical ...
Kelishadi Roya R Department of Pediatrics, Child Growth and Development Research Center, Research Institute for Primary Prevention of Non-communicable Disease, Isfahan University of Medical Sciences, Isfahan, - - 2014
This study aimed to compare the cytochrome P450 1A1 (CYP1A1) gene expression in the cord blood of infants born from mothers living in low- and high-air polluted areas. The study was conducted in Spring 2012 in Isfahan, the second large and air-polluted city in Iran. The study comprised 60 neonates, ...
Vasconcellos Mauricio Teixeira Leite de MT Escola Nacional de Ciências Estatística, Instituto Brasileiro de Geografia e Estatística, Rio de Janeiro, - - 2014
This paper describes the sample design for the National Survey into Labor and Birth in Brazil. The hospitals with 500 or more live births in 2007 were stratified into: the five Brazilian regions; state capital or not; and type of governance. They were then selected with probability proportional to the ...
Shah Nidhi Agrawal NA Lucile Packard Children's Hospital Stanford, Palo Alto, California, - - 2014
Amplitude-integrated electroencephalography (aEEG) is a method for continuous monitoring of brain activity that is increasingly used in the neonatal intensive care unit. In its simplest form, aEEG is a processed single-channel electroencephalogram that is filtered and time-compressed. Current evidence demonstrates that aEEG is useful to monitor cerebral background activity, diagnose ...
Sulkowski Jason P JP Center for Surgical Outcomes Research and Department of Surgery, Nationwide Children's Hospital, Columbus, - - 2014
The aim of this study was to evaluate surgical treatments and outcomes in a multi-institutional cohort of neonates with Hirschsprung's disease (HD). Using the Pediatric Health Information System (PHIS) from 1999 to 2009, neonates diagnosed with HD were identified and classified as having a single stage pull-through (SSPT) or multi-stage ...
Raj Sunil S Assistant Professor, Department of Pediatrics, Dr SMCSI Medical College , Trivandrum, Kerala, India - - 2014
Universal screening of all neonates has for long been recognized as the most effective method to detect congenital hypothyroidism. However, various maternal as well as perinatal factors can influence the cord blood TSH levels. To evaluate the effect of perinatal factors on cord blood TSH level variations in neonates born ...
Meisser-Redeuil Karine - - 2014
A UHPLC-MS/MS method for the determination of folate (vitamin B9) in infant formula and adult/pediatric nutritional formula was assessed for compliance with standard method performance requirements set forth by the AOAC INTERNATIONAL Stakeholder Panel for Infant Formula and Adult Nutritionals (SPIFAN). A single-laboratory validation (SLV) study was conducted as the ...
Nigam Js J Department of Pathology, Saraswathi Institute of Medical Sciences, Anwarpur, Pilkhuwa, Hapur, Uttar Pradesh, - - 2014
The antenatal health-care given to pregnant women has great influence on the rates of perinatal death and morbidity. Amongst the different causes of perinatal mortality, low birth weight (LBW) is the single most significant factor therefore placenta from all the LBW babies (LBWB) should be examined routinely to find out ...
Purkait Radheshyam R Department of Paediatric Medicine, Nil Ratan Sircar Medical College and Hospital, Acharya Jagadish Chandra Bose Road, Kolkata, West Bengal, - - 2014
Medium chain triglyceride (MCT)-based diet, total parenteral nutrition (TPN) and repeated paracentesis are considered as supportive management for congenital chylous ascites (CCA). TPN is considered where therapy with oral MCT is poorly tolerated by the patient especially young infant with unstable hemodynamic. Surgery is recommended when medical therapy fails. Herein, ...
Allegaert Karel K University Hospitals Leuven, Neonatal Intensive Care Unit , Herestraat 49, 3000 Leuven , Belgium +32 16 343850 ; +32 16 343209 ; - - 2014
Introduction: Extensive within-population variability is the essence of neonatal pharmacology. Despite this, infants remain one of the last therapeutic orphans. Together with additional legal initiatives, tailoring of already available tools (modeling, covariates, pharmacovigilance) may significantly improve pharmacotherapy in infants. Areas covered: Modeling approaches that hold the promise to improve pharmacotherapy ...
Wu Tai T Department of Neonatology, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, - - 2014
To explore the imaging findings of neonatal infants infected with enteroviruses. A retrospective study was conducted on 12 patients who were diagnosed with encephalitis caused by enterovirus. Clinical presentation, cranial ultrasonography (cUS), magnetic resonance imaging (MRI) findings and neurodevelopment outcome of 12 cases were analysed. Twelve infants, with a gestational ...
Ecochard-Dugelay Emmanuelle - - 2014
Acute viral respiratory exacerbation is one of the most common conditions encountered in a paediatric emergency department (PED) during winter months. We aimed at defining clinical predictors of chest radiography prescription and radiographic abnormalities, among infants with bronchiolitis in a paediatric emergency department. We conducted a prospective cohort study of ...
Battersby C C Imperial College London, London, - - 2014
Lack of a universal case-definition hinders (NEC) surveillance and clinical trials. Bell's staging, although widely used, was devised to guide surgical management after diagnosis(1). We aimed to develop an evidence-based NEC case-definition. We used the National Neonatal Research Database, that holds data extracted from the electronic records of babies admitted ...
Carbajal R R Trousseau Hospital, Paris, France Inserm U953, Paris, France UPMC, Paris, - - 2014
Pain and stress induced by mechanical ventilation, invasive procedures, or painful diseases supports the use of sedation/analgesia (S/A) in newborns admitted to Neonatal Units (NNUs). To date, these practices have not been studied on a large scale. To determine current clinical practices regarding the use of S/A drugs in NNUs ...
Fairclough G G Birmingham Women's Hospital NHS Foundation Trust, Birmingham, - - 2014
Respiratory syncytial virus (RSV) is the leading cause of bronchiolitis in infants. Palivizumab is an anti-RSV monoclonal antibody providing passive immunity against RSV. The Joint Committee for Vaccination and Immunisation (JCVI) have produced guidelines for high-risk babies that fulfil the criteria for receiving Palivizumab. Service evaluation of the dedicated Paviluzumab ...
Corcoran P P National Perinatal Epidemiology Centre, University College Cork, Cork, - - 2014
Perinatal mortality has decreased in high-resource countries but cause of death, especially for stillbirths, is often unexplained. The Irish National Perinatal Epidemiology Centre (NPEC) established a national clinical audit on perinatal deaths to better identify causes of death and associated risk factors. After piloting the NPEC Perinatal Death Notification Form ...
Taşkınlar Hakan H Department of Pediatric Surgery, School of Medicine, Mersin University, Mersin, - - 2014
Although necrotizing enterocolitis (NEC) is a frequently encountered entity in premature infants in the neonatal intensive care unit, intussusception is extremely rare. Abdominal distension, bilious/non-bilious gastric residuals and bloody stool are the common clinical findings of both entities. Here we present three cases of intussusception misdiagnosed as NEC, two of ...
Pavić Dario - - 2014
There is strong evidence that the sex ratio at birth is partially determined by environmental and social factors. The modern change in those factors serves as an explanation for the secular decline in sex ratio at birth in most of the industrialized countries. This article is the reexamination of the ...
Seager E E Birmingham Womens Hospital, Birmingham, - - 2014
Lumbar puncture (LP) is usually performed when there is a clinical suspicion of meningitis in babies with suspected sepsis. NICE recently published their guidelines on 'antibiotics for early-onset neonatal infections' with guidance on when LPs should be considered. To audit the number of LPs carried out in term babies (>37+0 ...
Neville G G National Maternity Hospital, Holles Street, Dublin 2, - - 2014
: Accurate identification of high risk groups and focused efforts at reducing their risk may be the most effective method currently available of reducing the incidence and associated squeale of preterm birth. A preterm surveillance clinic was established in March 2012 to provide expert management of those at risk of ...
Higgins M M Obstetrics and Gynaecology, University College Dublin, National Maternity Hospital, Dublin, - - 2014
: The aim of this study was to review the clinical outcomes of congenital haemangiomas and lymphangiomas in our unit. Retrospective cohort study. Between January 2004 and March 2013, over 67,000 infants delivered in Mount Sinai, of which 45 had a diagnosis of haemangioma (n = 23) or lymphangioma (n ...
Rasiah Sv S South West Midlands Newborn Network, Birmingham, UK Birmingham Women's Hospital NHS Foundation Trust, Birmingham, - - 2014
One of the aims of managed newborn clinical networks is to monitor and report on their neonatal mortality as an outcome measures of improvements in quality of care. The South West Midlands Newborn Network (SWMNN) was established in 2004. Badger electronic patient database has been used since 2009 across all ...
Yin Xiaojuan - - 2014
The aim was to investigate the surfactant protein B (SP-B) expression in the bronchoalveolar lavage fluid (BALF) of full-term neonates with respiratory distress syndrome (RDS). The enzyme-linked immunosorbent assay was performed to assess SP-B expression in BALF of 60 full-term neonates with RDS and 23 healthy neonates and correlation of ...
Nomura Shiho - - 2014
Preterm infants show transient hypothyroxinemia without thyroid-stimulating hormone (TSH) elevation. In addition, the degree of neurodevelopmental delay in preterm infants become severe according to the decreasing gestational age (GA). Because of the crucial role of thyroid hormones in brain development, hypothyroxinemia has the potential to cause developmental delay; however, the ...
Edmonds Joyce K - - 2014
Cesarean birth is the most common surgical procedure in the United States and is associated with increased morbidity and mortality when compared to vaginal birth. Of the more than 4 million births a year, one in three is now a cesarean. A better understanding of the clinical indications contributing to ...
Mekrungcharas Thanyaporn - - 2014
In Thailand, Iodine Deficiency Disorder (IDD) has been one of the most serious nutritional problems for over 50 years, especially for infants and young children. Iodine is an essential component of thyroid hormones, which are necessary for brain and body development especially during the first 2 years of life. During ...
Palanisami B B St Mary's Hospital, Central Manchester University Hospitals NHS Foundation Trust, Manchester, - - 2014
Asymptomatic cardiac murmurs are commonly detected on newborn examination. These babies are frequently referred to paediatric cardiology services. To reduce waiting time for evaluation of these neonates, a neonatologist run echocardiography clinic was set up. To analyse the cardiac disease burden and time to diagnosis of neonates referred to neonatal ...
Roberts Jessica K JK Division of Clinical Pharmacology, Department of Pediatrics, University of Utah School of Medicine, University of Utah Health Sciences Center, 295 Chipeta Way, Salt Lake City, UT, 84108, - - 2014
Antimicrobials and antivirals are widely used in young infants and neonates. These patients have historically been largely excluded from clinical trials and, as a consequence, the pharmacokinetics and pharmacodynamics of commonly used antibacterials, antifungals, and antivirals are incompletely understood in this population. This review summarizes the current literature specific to ...
- - 2014
Data from large randomized clinical trials indicate that therapeutic hypothermia, using either selective head cooling or systemic cooling, is an effective therapy for neonatal encephalopathy. Infants selected for cooling must meet the criteria outlined in published clinical trials. The implementation of cooling needs to be performed at centers that have ...
Autmizguine J - - 2014
Infants are therapeutic orphans. Many drugs used in infantsare used "off-label", increasing the risk of drug toxicity and suboptimal efficacy in this vulnerable population. This knowledge gap in clinical pharmacology is partly attributed to challenges associatedwith conducting clinical trials in infants. Consequently, there is a need for novel and efficient ...
Sola Augusto A President Ibero American Society of Neonatology - - 2014
Oxygen is a neonatal health hazard that should be avoided in clinical practice. In this review, an international team of neonatologists and nurses assessed oxygen saturation (SpO2 ) targeting in preterm infants and evaluated the potential weaknesses of randomised clinical trials. Conclusions SpO2 of 85-89% can increase mortality and 91-95% ...
Shankaran Seetha S Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI, 48201, USA, - - 2014
This article reviews the pathophysiology of hypoxic-ischemic brain injury, and the impact of hypothermia as neuroprotection in the clinical setting. The results of trials performed in well resourced and mid and low resourced countries is presented. Infant and childhood outcome following hypothermia is provided. Biomarkers of outcome that are clinical, ...
Honsel Maik M Paediatric and Neonatal Intensive Care Unit, Great Ormond Street Hospital for Children NHS Foundation Trust, - - 2014
Neuromuscular blocking agents (NMBA) are used in a range of critical illnesses in neonates and infants, despite a lack of guidelines and professional standards. This study reviewed the current evidence base and ascertained UK practice regarding the continuous use of these agents in this age range. We reviewed the literature ...
Small Susan A SA School of Audiology & Speech Sciences, University of British Columbia , Vancouver , - - 2014
Objective: To determine whether ipsilateral/contralateral asymmetries in the bone-conduction (BC) ASSR are robust enough in infants to be used clinically to isolate the test ear. Design: Retrospective investigation of three two-channel BC ASSR datasets. Subjects: Forty-eight adults (mean age 26.7 years), 49 infants (mean age 29.6 weeks). Methods: BC ASSR ...
Barnhart Kurt T KT Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address: - - 2014
Well-designed and -conducted clinical trials are needed to further advance the field for reproductive medicine. However, current reporting of outcomes of trials is ambiguous and disparate. In this review it is offered that the preferred outcome for clinical trials in reproductive medicine should be live birth. Multiple births should be ...
Aydın Halil Ibrahim HI Department of Pediatrics, Gülhane Military Medical Academy, Ankara. - - 2014
The aim in this study was to determine the factors affecting leptin and soluble leptin receptor (sOB-R) levels in term small for gestational age (SGA) and appropriate for gestational age (AGA) newborns. The study group consisted of SGA (n=20) and AGA (n=20) newborns and their mothers. The leptin and sOB-R ...
Van Noolen L L Département de Biochimie, Toxicologie et Pharmacologie, Institut de Biologie et Pathologie, CHU Grenoble, Grenoble, - - 2014
Vitamin B12 deficiency can lead to serious haematological and neurological signs in infants. The reported clinical cases of vitamin B12 deficiency were found in exclusively breast-fed infants whose asymptomatic mothers were diagnosed later with pernicious anaemia. For the infants, the diagnosis required urinary methylmalonic acid quantification (grossly elevated in these ...
Finkel Richard S RS Divisions of Neurology, Nemours Children's Hospital, Orlando, - - 2014
To determine the feasibility and safety of respiratory muscle function testing in weak infants with a progressive neuromuscular disorder. Respiratory insufficiency is the major cause of morbidity and mortality in infants with spinal muscular atrophy type I (SMA-I). Tests of respiratory muscle strength, endurance, and breathing patterns can be performed ...
Benkoe Thomas M TM Department of Pediatric Surgery, Medical University of Vienna, Austria. Electronic address: - - 2014
In recent years several potential biochemical markers have been evaluated to facilitate a reliable diagnosis of necrotizing enterocolitis (NEC), but none have made progress to clinical routine. We performed a comparative assessment in premature infants to evaluate the diagnostic value of the routinely available cytokine interleukin (IL)-8, and two promising ...
Tidmarsh G F GF Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, - - 2014
Hemolytic disease in newborns can result from a number of conditions, which can place such infants at an increased risk for the development of severe hyperbilirubinemia. Because the catabolism of heme produces equimolar amounts of carbon monoxide (CO) and bilirubin, measurements of end-tidal breath CO (corrected for ambient CO) or ...
Patel Shyama D SD *Department of Pediatrics/Newborn Medicine, Weill Cornell Medical College, 1300 York Avenue, New York, NY 10025, - - 2014
Neonatal encephalopathy resulting from HI (hypoxia-ischaemia) continues to be a significant cause of mortality and morbidity in infants and children, affecting 1-2/1000 live term births and up to 60% of pre-term births. In order to understand the pathophysiology of this insult, as well as design therapeutic interventions, it is important ...
Erfanianahmadpoor Mahmood M Anatomy Department, Mashhad Medical Branch, Islamic Azad University, Mashhad, - - 2014
To assess specific anti-cytomegalovirus (CMV) antibodies, clinical status, and demographic data in pregnant women and their infants in northeast Iran. This cross-sectional study was conducted on 225 systematic randomly selected-pregnant women and their newborns attending public hospitals in Mashhad, Iran between December 2007 and January 2008. Two specialists performed clinical ...
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