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Abhyankar Swapna S National Library of Medicine, Bethesda, - - 2013
Knowledge about maternal history is critical for guiding certain aspects of newborn clinical care as well as for research on neonatal issues. However, often the only maternal history available in the newborn record is in the clinical notes. We are using data from the MIMIC-II database for a clinical study ...
García Evamariely - - 2013
Adrenocortical carcinoma (ACC) is a rare neoplasm in children. Most patients with ACC suffer syndromes of adrenal hormone overproduction including hypercortisolism, hyperaidosteronism or virilization. We describe the case of an infant girl who presented features of virilization associated with elevated testosterone and DHEA levels due to the presence of a ...
Bekhof Jolita - - 2012
Late-onset neonatal sepsis (LOS) in preterm infants is an important cause of morbidity and mortality in preterm infants. Since presenting symptoms may be non-specific and subtle, early and correct diagnosis is challenging. We aimed to develop a nomogram based on clinical signs, to assess the likelihood of LOS in preterms ...
Tokumasu Hironobu - - 2012
BACKGROUND: Clinical chorioamnionitis and histological chorioamnionitis are important risk factors for neonatal complications and neurodevelopmental impairment in premature infants. However, it is unclear whether a diagnosis of clinical chorioamnionitis is sufficient to establish a diagnosis of histological chorioamnionitis. Here, we evaluated the predictive value of clinical chorioamnionitis in the diagnosis ...
van Thuijl Anders - - 2012
The double-blind placebo-controlled food challenge (DBPCFC) is currently the gold standard to diagnose cow's milk allergy (CMA). However, DBPCFCs are burdensome, expensive and require specialised facilities. For primary care physicians, selective and consistent referral to DBPCFC of infants suspected of CMA may be difficult. The objective of this study was ...
Schmölzer Georg M - - 2012
Tracheal intubation remains a common procedure during neonatal intensive care. Rapid confirmation of correct tube placement is important because tube malposition is associated with serious adverse outcomes. The current gold standard test to confirm tube position is a chest radiograph, however this is often delayed until after ventilation has commenced. ...
El-Khashab Mostafa - - 2012
Brain abscess in young infants is extremely rare and usually associated with a previous history of bacterial meningitis or septicemia. Here we report a cerebellar abscess mimicking brain tumor with atypical clinical and paraclinical presentations. A two-month old previously well-baby boy was referred to us with persistent vomiting, strabismus and ...
Shankaran Seetha - - 2012
This article covers the outcome of full-term infants with encephalopathy due to hypoxic-ischemia and pathophysiology of brain injury following hypoxic-ischemia. Clinical and imaging evidence for hypothermia for neuroprotection is presented. The outcome of infants with hypothermia for encephalopathy due to hypoxic-ischemia from recent trials is summarized. Facts regarding the clinical ...
Shore Richard M - - 2012
This is the continuation of a two-part review of rickets. This part emphasizes the specific pathophysiology, clinical features, pathoanatomy and radiographic findings of vitamin D deficiency rickets. Other forms of rickets, differential diagnostic considerations and the potential relationship between low levels of vitamin D metabolites and unexplained fractures in infants ...
Mussap M - - 2012
Despite a 35% decline in the mortality rate for infants aged <5 years over the past two decades, every year nearly 40% of all deaths in this age group occur in the neonatal period, defined as the first 28 days of life. New knowledge on molecular and biochemical pathways in ...
Ohishi Akira - - 2013
We report on a Filipino neonate with early onset and prolonged hyperbilirubinemia who was delivered by a vacuum extraction due to a prolonged labor. Subsequent studies revealed adrenal hemorrhage and glucose-6-phosphate dehydrogenase (G6PD) deficiency. It is likely that asphyxia and resultant hypoxia underlie the occurrence of adrenal hemorrhage and the ...
Bailey Dana D Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, - - 2013
With an ever-increasing clinical interest in vitamin D insufficiency, numerous automated immunoassays, protein binding assays, and in-house LC-MS/MS methods are being developed for the quantification of 25-hydroxyvitamin D(3) (25(OH)D(3)). Recently, LC-MS/MS methods have identified an epimeric form of 25(OH)D(3) that has been shown to contribute significantly to 25(OH)D(3) concentration, particularly ...
Nelson Karin B KB Children's Hospital National Medical Center, Washington, District of Columbia, USA. - - 2012
Neonatal encephalopathy (NE) is a major predictor of death and long-term neurologic disability, but there are few studies of antecedents of NE. To identify antecedents in a large registry of infants who had NE. This was a maternal and infant record review of 4165 singleton neonates, gestational age of ≥ ...
SÅ‚omka Artur - - 2012
Abstract Objective: To assess the relationship between parameters of iron homeostasis in infants and clinical features characterising newborns and their mothers. Methods: The goal of the present work was to determine nine iron status parameters, i.e. hepcidin, prohepcidin, soluble transferrin receptor, ferritin, total iron binding capacity, unsaturated iron binding capacity, ...
Maclean Joanna E - - 2012
OBJECTIVE: To determine the prevalence of sleep-disordered breathing (SDB) symptoms and respiratory events during sleep in infants with cleft lip and/or palate (CL/P). DESIGN: Prospective observational study. SETTING: Cleft palate clinic, tertiary care paediatric hospital, before palate surgery. PATIENTS: Consecutive newborn infants with CL/P. MAIN OUTCOME MEASURES: Demographics, clinical history, ...
Hussain Shanawaz - - 2012
The authors report a case of hyperekplexia presenting in the neonatal period resistant to clonazepam that responded subsequently to levetiracetam. Hyperekplexia is often misdiagnosed as epilepsy and can be difficult to manage with a particular concern over neonatal apnea and an increased risk of sudden infant death syndrome. The mainstay ...
Trevisanuto Daniele - - 2012
Oxygen has been widely used in neonatal resuscitation for about 300 years. In October 2010, the International Liaison Committee on Neonatal Resuscitation released new guidelines. Based on experimental studies and randomized clinical trials, the recommendations on evaluation and monitoring of oxygenation status and oxygen supplementation in the delivery room were ...
Cerbo R M - - 2012
Near infrared spectroscopy (NIRS) measures the regional tissue oxygen saturation (rSO2) of various organs and provides a reflection of the balance between tissue oxygen supply and demand. Oxymetry assessed via NIRS has been proposed as a 'standard of care' and today it is already widely used in the NICU. This ...
Amin Sachin C - - 2012
Objective: Several case reports and retrospective studies have reported a temporal association between red blood cell (RBC) transfusions and necrotizing enterocolitis (NEC). In this article, we review the clinical evidence and biological plausibility of the association between RBC transfusions and NEC. Methods: A literature search was performed using the databases ...
Gancia Paolo - - 2012
Therapeutic hypothermia is now the standard of care for brain injury control in term infants with perinatal hypoxic ischemic encephalopathy (HIE). Accumulated evidence shows a reduction in mortality and long-term neurodevelopmental disability at 12-24 months of age, with more favourable effects in the less severe forms of HIE. Only few ...
Patra Sushma - - 2012
To analyse the clinicopathological features of neonatal mucormycosis Retrospective analysis of cases of neonatal gastrointestinal mucormycosis. THERE WERE SIX NEONATES WITH MALE: female ratio of 1:1. Except one all were preterm babies. The clinical presentation was abdominal distension in the majority. All were clinically diagnosed as either NEC or toxic ...
Ivanov Ivan S IS Clinic of Children's and Genetic Diseases, Medical University, Plovdiv, Bulgaria. - - 2012
Data on cytomegalovirus infection (CMV) prevalence and course in hospitalized infants are rather scarce, obsolete and considerably inconsistent. to determine the prevalence, rate of clinical manifestations, risk factors and predictive capacity of clinical manifestations of CMV infection in hospitalized infants during their first year of life. All 163 infants hospitalized ...
Khan Rizwan A - - 2012
Neonatal necrotizing enterocolitis, the most common gastrointestinal emergency in neonates, typically affects the preterm infants and carries high mortality. Classic clinical trad consists of abdominal distension, bloody stools, and pneumatosis intestinalis. Occasionally, signs and symptoms may not be classic and a number of papers have highlighted the difficulty of relying ...
Ogle Ashley - - 2012
AIMS: To analyze toxicological findings of accidental deaths involving oxycodone to determine demographic characteristics and clinical histories. METHODS: Accidental deaths in which oxycodone was mentioned as a cause of death were analyzed. The sample included all persons deceased in Hillsborough County in 2009 where oxycodone was present. The entire sample ...
Volpe Joseph J - - 2012
This Point of View article addresses neonatal encephalopathy (NE) presumably caused by hypoxia-ischemia and the terminology currently in wide use for this disorder. The nonspecific term NE is commonly utilized for those infants with the clinical and imaging characteristics of neonatal hypoxic-ischemic encephalopathy (HIE). Multiple magnetic resonance imaging studies of ...
Bardají Azucena - - 2012
Malaria continues to represent a huge global health burden on the most vulnerable populations. The Intermittent Preventive Treatment (IPT) strategy has been shown to be an efficacious intervention in preventing most of the deleterious effects of malaria in pregnant women and infants. Yet, the effectiveness of the IPT strategy may ...
Dong Shu - - 2012
Placental infection with Plasmodium falciparum is associated with increased levels of proinflammatory cytokines, including tumor necrosis factor alpha (TNF-α) and gamma interferon (IFN-γ), and previous studies have associated increased levels of these cytokines with low birth weight (LBW), especially for malaria-infected primigravidae. To define the contribution of TNF-α and IFN-γ ...
Senn Nicolas - - 2012
[This corrects the article on p. e1001195 in vol. 9.].
Sindgikar Seema Pavaman SP Department of Pediatrics, K. S. Hegde Medical Academy, NITTE University, Derlakatte, Mangalore, 575 018 Karnataka - - 2013
Propionic acidemia (PA), an uncommon organic acidemia has varied clinical and metabolic presentation causing difficulty and delay in the diagnosis. We report a case of PA in an infant who presented with failure to thrive, acute encephalopathy due to severe hyperammonemia without acidosis and fungal sepsis. The biochemical basis of ...
Guzelbektes H - - 2012
BACKGROUND: Gastroesophageal reflux (GER) is the presence of gastric contents proximal to the stomach. Pathologic consequences secondary to GER are termed gastroesophageal reflux disease (GERD). OBJECTIVES: The purpose of this study was to determine the prevalence of GER and GERD in premature calves by endoscopic examination. ANIMALS: Ten healthy and ...
de Sousa Alexandra - - 2012
Background. Intermittent preventive treatment in infants (IPTi) is a new malaria control strategy coupled with the delivery of routine immunizations recommended by the World Health Organization since 2009 for countries with moderate to high endemicity. To evaluate its safety profile and identify potential new adverse events (AEs) following simultaneous administration of ...
Le Port Agnès - - 2012
Malaria infection of the placenta during pregnancy was found to be associated with infant susceptibility to malaria. Other factors such as the intensity of malaria transmission and the nutritional status of the child might also play a role, which has not been adequately taken into account in previous studies. The ...
Hon Kam Lun - - 2012
Neonatal lupus erythematosus (NLE) refers to a clinical spectrum of cutaneous, cardiac, and systemic abnormalities observed in newborn infants whose mothers have autoantibodies against Ro/SSA and La/SSB. The condition is rare and usually benign and self-limited but sometimes may be associated with serious sequelae. We review the pathophysiology, clinical features, ...
Senn Nicolas - - 2012
Intermittent preventive treatment in infants (IPTi) has been shown in randomized trials to reduce malaria-related morbidity in African infants living in areas of high Plasmodium falciparum (Pf) transmission. It remains unclear whether IPTi is an appropriate prevention strategy in non-African settings or those co-endemic for P. vivax (Pv). In this ...
D'Alessandro Umberto - - 2012
Despite the protection provided by several factors, including maternal antibodies, the burden of malaria in young infants may be higher than previously thought. Infants with congenital or neonatal malaria may have a different clinical presentation than older children, and diagnosis may be confused with other neonatal diseases due to an ...
Nguyen Michelle C - - 2012
The prevalence of congenital talipes equinovarus (clubfoot) in Vietnam is estimated to be approximately one in 1000 births. To date, no epidemiological studies have been conducted in this country to assess risk factors associated with this deformity. The purpose of this study was to evaluate specific environmental and socioeconomic factors ...
Been Jasper V - - 2012
Histological chorioamnionitis (HC) is an intrauterine inflammatory process highly associated with preterm birth and adverse neonatal outcome. HC is often clinically silent and diagnosed postnatally by placental histology. Earlier identification could facilitate treatment individualisation to improve outcome in preterm newborns. Develop a clinical prediction rule at birth for HC and ...
Sleed Michelle - - 2013
A pilot baby clinic in a hostel for homeless families has been established to address the specific attachment and developmental needs of infants living in temporary accommodation. The aim of this study was to assess whether this clinic model was associated with more positive outcomes than mainstream community services in ...
Chiabi Andreas - - 2011
Sepsis is an important cause of morbidity and mortality in neonates especially in developing countries where identification of the germs and treatment is often unsatisfactory. The aim of the study was to assess the clinical presentation, and bacteriological profile of neonatal infections, and the sensitivity of the causative germs to ...
Nampoothiri Sheela - - 2011
Patients with isolated hypertriglyceridemia usually present with recurrent abdominal pain, pancreatitis, eruptive xanthomas, lipemia retinalis and hepatosplenomegaly. We describe the diagnosis and treatment of an infant with severe hypertriglyceridemia. The child was found to be heterozygous for two novel mutations in the lipoprotein lipase gene.
Iwayama Mariko - - 2011
The aim of the present study was to determine whether parental age has any influence on child health. Well-baby check-up data at 1 month and at 12 months of age were used. The trends of parental age in association with growth measurements, incidence of physical and developmental abnormalities, occurrence of ...
Nagano Nobuhiko - - 2011
BACKGROUND: Late preterm infants (LPIs; 34-37 gestational weeks at birth) have higher risk for several morbidities than do term infants (TIs). It has been suggested that a cholesterol and fatty acid supply may improve their outcomes. We investigated the lipoprotein subclass profile in LPIs to evaluate their early postnatal lipid ...
Madden Michelle E - - 2011
The prevalence of methadone-related overdose deaths is increasing worldwide and has been a topic of recent debate. Methadone-related deaths, to this point, have not been systematically reviewed in the state of Vermont. All of the methadone-related fatalities from 2001 to 2006 (total, 76 cases), which were examined by the Vermont ...
Kim Jihyun - - 2011
To cite this article: Kim J, Chang E, Han Y, Ahn K, Lee S-I. The incidence and risk factors of immediate type food allergy during the first year of life in Korean infants: a birth cohort study. Pediatric Allergy Immunology 2011: Doi: 10.1111/j.1399-3038.2011.01163.x. ABSTRACT: Objectives:  We conducted this study to ...
Metcalfe Amy - - 2011
Metcalfe A, Lail P, Ghali WA, Sauve RS. The association between neighbourhoods and adverse birth outcomes: a systematic review and meta-analysis of multi-level studies. Paediatric and Perinatal Epidemiology 2011; 25: 236-245. Many studies have examined the role of neighbourhood environment on birth outcomes but, because of differences in study design ...
Pierce Karen - - 2011
To determine the feasibility of implementing a broadband screen at the 1-year check-up to detect cases of autism spectrum disorders (ASD), language delay (LD), and developmental delay (DD). The Communication and Symbolic Behavior Scales Developmental Profile Infant-Toddler Checklist was distributed at every 1-year pediatric check-up; 137 pediatricians and 225 infants ...
Barros Fernando C - - 2011
OBJECTIVE: To assess the prevalence of preterm birth among low birthweight babies in low and middle-income countries. METHODS: Major databases (PubMed, LILACS, Google Scholar) were searched for studies on the prevalence of term and preterm LBW babies with field work carried out after 1990 in low- and middle-income countries. Regression ...
Yang Xiao - - 2011
Aim:  To investigate the incidence, causes and delivery methods of iatrogenic preterm births. Material & Methods:  A retrospective study was conducted to review a cohort of preterm birth records to learn the incidence, causes and delivery methods of 828 iatrogenic preterm births from January 2004 to June 2007. The chi-squared ...
Kalay Salih - - 2011
Cerebral edema resulting in elevated intracranial pressure is a well-known complication of galactosemia. Lumbar puncture was performed for the diagnosis of clinically suspected bacterial meningitis. Herniation of cerebral tissue through the foramen magnum is not a common problem in neonatal intensive care units because of the open fontanelle in infants. ...
McDonald Jenny L - - 2011
Aim:  To measure, describe and investigate potential predictors of early developmental progress in urban Aboriginal infants. Methods:  The Gudaga study is a longitudinal birth cohort study of urban Aboriginal infants. At 12 months 134 infants were assessed using the Griffiths Mental Development Scales (GMDS). The infants' developmental progress was compared with ...
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