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Results 101 - 150 of 847
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Gal S S Department of Pediatrics, Bnai Zion Medical Center, The B&R Rappaport Faculty of Medicine, Technion, 47 Golomb Street, Haifa, 31048, Israel, - - 2014
Our objective was to assess within a feasibility study the correlation and agreement of transcutaneous carbon dioxide (PtcCO2) monitoring with venous carbon dioxide (PvCO2) in infants with bronchiolitis in the emergency room (ER) and pediatric department. Sixty infants (aged 3.6 ± 3.3 months) admitted to our ER with bronchiolitis were included. PtcCO2 measurements ...
Velasco Roberto R Pediatrics Department, Rio Hortega University Hospital, Valladolid, - - 2014
There is limited evidence about the diagnostic value of urine dipsticks in young febrile infants. The aim of this study was to determine whether urine dipsticks would identify positive urine cultures in febrile infants of less than 90-days-of-age. This study was a sub-analysis of a prospective multi-centre study developed in ...
Kheddache Yasmina Y Department of Electrical Engineering, École de Technologie Supérieure, Montréal Quebec, Canada. Electronic address: - - 2014
A new approach to the automatic quantification of the acoustic parameters of the cries of healthy newborns and newborns with pathologies is presented. The purpose of the present study was to examine the relationship between acoustic parameters and pathologies of interest to characterize healthy and pathologic cries of newborns. Using ...
Suaini Noor H A NH Murdoch Childrens Research Institute, Parkville, Victoria, - - 2014
To investigate the relationship between genetic and environmental exposure and vitamin D status at age one, stratified by ethnicityThis study included56312-month-old infants in the HealthNuts population-based study. DNA from participants' blood samples was genotyped using SequenomMassARRAY MALDI-TOF system on 28 single nucleotide polymorphisms (SNPs) in six genes. Using logistic regression, ...
González-González Nieves L NL Departamento de Obstetricia y Ginecología, Hospital Universitario de Canarias, y, La Laguna, - - 2014
Objective: To determine whether the use of customized curves (CC) allows better detection of large- (LGA) or small-for-gestational age (SGA) infants at risk of adverse perinatal morbidity than non-CC in women with diabetes mellitus (DM). Material and Methods: A model of CC was applied to all infants of diabetic mothers ...
Bastek Jamie A JA Maternal and Child Health Research Program, Department of Obstetrics & Gynecology, Center for Research on Reproduction and Women's Health, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania. Electronic address: - - 2014
To examine whether variation in neighborhood context is associated with preterm birth outcomes and gestational age at delivery in Philadelphia, and to determine whether these associations might persist when considering relevant individual-level variables. We analyzed individual-level data collected for a prospective cohort study of singleton pregnancies with preterm labor. We ...
Can Emrah E * Edirne State Hospital, Neonatal Intensive Care Unit , Edirne , - - 2014
Objective: To evaluate the prevalence of auditory neuropathy (AN) in late preterms treated with phototherapy for hyperbilirubinemia. Design: Prospective observational study comprising late preterms treated with phototherapy for hyperbilirubinemia. Newborns were screened with combined transient-evoked otoacoustic emissions (TEOAEs) / automated auditory brainstem responses (AABR). Infants who failed screening underwent diagnostic ...
Clarke Diana F DF 1Section of Pediatric Infectious Diseases, Boston Medical Center, Boston, Massachusetts; 2Division of Clinical Pharmacology, University of Alabama at Birmingham, Birmingham, Alabama; 3Merck Research Laboratories, Whitehouse Station, New Jersey; 4Pediatric Infectious Diseases, David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, California; 5Department of Pediatrics, University of California, San Diego and Rady Children's Hospital San Diego, La Jolla, California; 6Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland; 7Division of AIDS, National Institute of Health, Bethesda, Maryland; 8Merck Research Laboratories, North Wales, Pennsylvania; 9Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland; 10Statistical and Data Analysis Center, Harvard School of Public Health, Boston, Massachusetts; 11Department of Pediatrics, Boston University School of Medicine, Boston, - - 2014
IMPAACT P1097 was a multicenter trial to determine washout pharmacokinetics and safety of in utero/intrapartum exposure to raltegravir in infants born to HIV-infected pregnant women receiving raltegravir-based antiretroviral therapy. Twenty-two mother-infant pairs were enrolled; evaluable pharmacokinetic data was available from 19 mother-infant pairs. Raltegravir readily crossed the placenta, with median ...
Schnadower David D From the *Pediatric Emergency Medicine, Washington University School of Medicine, St. Louis, MO; †Pediatric Emergency Medicine, Morgan Stanley Children's Hospital, Columbia University College of Physicians and Surgeons, New York, NY; ‡Emergency Medicine and Pediatrics, University of California, Davis School of Medicine, Sacramento, CA; §Pediatric Emergency Medicine, Texas Children's Hospital, Baylor College of Medicine, Houston, TX; ∥Paediatric Emergency Medicine and Gastroenterology, Alberta Children's Hospital, Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Alberta, Canada; ¶Pediatric Emergency Medicine, Children's National Medical Center, George Washington University School of Medicine, Washington, DC; #Department of Biostatistics, Washington University School of Medicine, St. Louis, - - 2014
Controversy exists regarding the disposition of young febrile infants who present to emergency departments (EDs) with urinary tract infections (UTIs). In a large multicenter cohort of such patients, we aimed to determine the variation in patient disposition and clinical factors independently associated with outpatient management. Secondary analysis of a retrospective ...
Ozyurt Abdullah A Departments of Pediatric Cardiology, Erciyes University Faculty of Medicine, Kayseri, - - 2014
Palivizumab prophylaxis for RSV has been consistently reported to reduce the risk of hospital admissions related to RSV infection in children with symptomatic cardiac disease. This study was designed to investigate the efficacy of palivizumab prophylaxis among infants with congenital heart disease (CHD) in Turkey. A total of 91 infants ...
Guynes Anthony A 1University of Washington School of Medicine, Seattle, Washington USA, BS 2Puget Sound Blood Center and Department of Laboratory Medicine, University of Washington, Seattle, Washington USA 3Cardiothoracic Surgery, Seattle Children's Hospital and University of Washington School of Medicine, Seattle, Washington USA 4Transfusion Services, Seattle Children's Hospital, Seattle, WA USA 5Pediatric Cardiology, Seattle Children's Hospital and University of Washington School of Medicine, Seattle Washington - - 2014
ABO sensitization is a barrier to ABO-incompatible heart transplantation in infants. We investigate the development of ABO antibodies in infants with and without mechanical circulatory support (MCS) during their waiting period. Although the proportion of patients with antibodies was similar between the groups, the median age at antibody detection was ...
Restrepo-Mesa Sandra L SL Human Nutrition and Food Research Group, School of Nutrition and Dietetics, University of Antioquia, Carrera 75 N° 65-87, Bloque 44 of 109, Medellín, Colombia, - - 2014
Birth weight is a high impact factor in populations with high rates of immigration. This study establishes differences in birth weight (BW) and related factors among full-term newborn (NB) infants born to native and immigrant women living in Spain during 2007-2008. All NBs from Spanish mothers and mothers from the ...
Bernhard Wolfgang W Department of Neonatology, Faculty of Medicine, Eberhard-Karls-University, Calwer Straße 7, 72076, Tūbingen, Germany, - - 2014
Choline is essential to human development, particularly of the brain in the form of phosphatidylcholine, sphingomyelin and acetylcholine, for bile and lipoprotein formation, and as a methyl group donator. Choline is actively transported into the fetus, and maternal supply correlates with cognitive outcome. Interruption of placental supply may therefore impair ...
Hirsch Harry J HJ Neuropediatric Unit, Shaare Zedek Medical Center, The Hebrew University, Jerusalem, - - 2014
Background: Minipuberty describes transient activation of the hypothalamic-pituitary-gonadal axis occurring during the first few months of life. Hormone levels during minipuberty were described in only a few Prader-Willi syndrome (PWS) infant boys and have not been reported in PWS infant girls. Objectives: To measure gonadotropins and gonadal hormones in PWS ...
Lucenti Ausiliatrice A MS Centre, SCDU Neurology, Head and Neck Department, AOU "Maggiore della Carità", Corso Mazzini 18, 28100 Novara, Italy; Department of Health Sciences, University of Milano-Bicocca, Via Pergolesi 33, 20900 Monza, Italy. Electronic address: - - 2014
Month of birth has been associated in some studies with the susceptibility to develop Multiple Sclerosis (MS). However, only few studies have evaluated whether birth timing also affects disease progression. To assess whether season and month of birth are associated with disease progression in a large cohort of Italian patients. ...
Kittaka Setsuaki S Department of Pediatrics, Yamaguchi University Graduate School of Medicine, 1-1-1 Minamikogushi, Ube, Yamaguchi 755-8505, Japan. Electronic address: - - 2014
Human herpesvirus-6 (HHV-6) is a cause of exanthema subitum and, sometimes, of febrile seizures. However, the pathogenesis of febrile seizures associated with HHV-6 infection remains unclear. We investigated serum matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinases-1 (TIMP-1) levels in infants with HHV-6 infection. Serum levels of both MMP-9 and ...
Beneteau Anne A 1Department of Pediatrics, Centre Hospitalier de Versailles, Le Chesnay, France 2ACTIV, Association Clinique et Thérapeutique Infantile du Val de Marne, Saint Maur les Fossés, France 3GPIP, Pediatric Infectious Disease Group, France 4Clinical Research Center (CRC), Centre Hospitalier Intercommunal de Créteil, Créteil, France 5Department of pediatrics, Centre Hospitalier Intercommunal de Créteil, France 6Department of Microbiology, Hôpital Cochin, Paris, - - 2014
Bacterial meningitis (BM) is a major cause of morbidity and mortality in children. Sporadic cases of S. bovis have been described in neonates and infants. To assess the epidemiologic, clinical and biologic characteristics of these meningitis, we used the French Surveillance Network for BM in children. 227 pediatric wards working ...
Benki-Nugent Sarah S Departments of *Global Health, and ‡Epidemiology, University of Washington, Seattle WA, USA; §Department of Paediatrics and Child Health, University of Nairobi, Nairobi, - - 2014
Infant HIV-1 infection is associated with impaired neurologic and motor development. Antiretroviral therapy (ART) has the potential to improve developmental outcomes but the relative contributions of pre-ART disease status, growth, treatment regimen, and ART response during infancy are unknown. Kenyan ART-naive infants <5 months old initiated ART and had monthly ...
Simonato Manuela M Women's and Children's Health Department, University of Padova, 35128, Padova, Italy, - - 2014
Surfactant protein C (SP-C) is deemed as the surfactant protein most specifically expressed in type II alveolar epithelial cells and plays an important role in surfactant function. SP-C turnover in humans and its meaning in the clinical context have never been approached. In this study, we used mass spectrometry to ...
Chellani Harish H Neonatal Division, Department of Pediatrics, Safdarjung Hospital, New Delhi, 110029, India, - - 2014
Gastro-esophageal reflux (GER) is a common occurrence in newborns and a cause of anxiety to most parents. This physiological process needs to be closely differentiated from pathological reflux. The clinical signs in infants are generally non-specific which makes the distinction difficult. The diagnostic options in infants are limited, have low ...
Prahl M M Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, - - 2014
We describe two cases of premature infants who developed clinical and radiologic evidence of gastric lactobezoars within the same month in our neonatal intensive care unit while both were receiving medium-chain triglyceride-rich formula as part of the management of chylothoraces.
Vasconcellos Mauricio Teixeira Leite de MT Escola Nacional de Ciências Estatística, Instituto Brasileiro de Geografia e Estatística, Rio de Janeiro, - - 2014
This paper describes the sample design for the National Survey into Labor and Birth in Brazil. The hospitals with 500 or more live births in 2007 were stratified into: the five Brazilian regions; state capital or not; and type of governance. They were then selected with probability proportional to the ...
Yoon Jung Min JM Department of Pediatrics, Konyang University College of Medicine, Daejeon, - - 2014
Among the many factors associated with acute intestinal mucosal infection, numerous studies have proposed the usefulness of fecal calprotectin. The aim of this study was to evaluate the usefulness of fecal calprotectin in the diagnosis of necrotizing enterocolitis (NEC). We collected 154 stool samples from 16 very low birth weight ...
Bae Hyun Kyung HK Department of Pediatrics, Ewha Womans University School of Medicine, Seoul, - - 2014
The incidence of Kawasaki disease (KD) is rare in young infants (less than 3 months of age), who present with only a few symptoms that fulfill the clinical diagnostic criteria. The diagnosis for KD can therefore be delayed, leading to a high risk of cardiac complications. We examined the clinical ...
Shah Nidhi Agrawal NA Lucile Packard Children's Hospital Stanford, Palo Alto, California, - - 2014
Amplitude-integrated electroencephalography (aEEG) is a method for continuous monitoring of brain activity that is increasingly used in the neonatal intensive care unit. In its simplest form, aEEG is a processed single-channel electroencephalogram that is filtered and time-compressed. Current evidence demonstrates that aEEG is useful to monitor cerebral background activity, diagnose ...
Meisser-Redeuil Karine - - 2014
A UHPLC-MS/MS method for the determination of folate (vitamin B9) in infant formula and adult/pediatric nutritional formula was assessed for compliance with standard method performance requirements set forth by the AOAC INTERNATIONAL Stakeholder Panel for Infant Formula and Adult Nutritionals (SPIFAN). A single-laboratory validation (SLV) study was conducted as the ...
Raj Sunil S Assistant Professor, Department of Pediatrics, Dr SMCSI Medical College , Trivandrum, Kerala, India - - 2014
Universal screening of all neonates has for long been recognized as the most effective method to detect congenital hypothyroidism. However, various maternal as well as perinatal factors can influence the cord blood TSH levels. To evaluate the effect of perinatal factors on cord blood TSH level variations in neonates born ...
Nigam Js J Department of Pathology, Saraswathi Institute of Medical Sciences, Anwarpur, Pilkhuwa, Hapur, Uttar Pradesh, - - 2014
The antenatal health-care given to pregnant women has great influence on the rates of perinatal death and morbidity. Amongst the different causes of perinatal mortality, low birth weight (LBW) is the single most significant factor therefore placenta from all the LBW babies (LBWB) should be examined routinely to find out ...
Purkait Radheshyam R Department of Paediatric Medicine, Nil Ratan Sircar Medical College and Hospital, Acharya Jagadish Chandra Bose Road, Kolkata, West Bengal, - - 2014
Medium chain triglyceride (MCT)-based diet, total parenteral nutrition (TPN) and repeated paracentesis are considered as supportive management for congenital chylous ascites (CCA). TPN is considered where therapy with oral MCT is poorly tolerated by the patient especially young infant with unstable hemodynamic. Surgery is recommended when medical therapy fails. Herein, ...
Allegaert Karel K University Hospitals Leuven, Neonatal Intensive Care Unit , Herestraat 49, 3000 Leuven , Belgium +32 16 343850 ; +32 16 343209 ; - - 2014
Introduction: Extensive within-population variability is the essence of neonatal pharmacology. Despite this, infants remain one of the last therapeutic orphans. Together with additional legal initiatives, tailoring of already available tools (modeling, covariates, pharmacovigilance) may significantly improve pharmacotherapy in infants. Areas covered: Modeling approaches that hold the promise to improve pharmacotherapy ...
Wu Tai T Department of Neonatology, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, - - 2014
To explore the imaging findings of neonatal infants infected with enteroviruses. A retrospective study was conducted on 12 patients who were diagnosed with encephalitis caused by enterovirus. Clinical presentation, cranial ultrasonography (cUS), magnetic resonance imaging (MRI) findings and neurodevelopment outcome of 12 cases were analysed. Twelve infants, with a gestational ...
Ecochard-Dugelay Emmanuelle - - 2014
Acute viral respiratory exacerbation is one of the most common conditions encountered in a paediatric emergency department (PED) during winter months. We aimed at defining clinical predictors of chest radiography prescription and radiographic abnormalities, among infants with bronchiolitis in a paediatric emergency department. We conducted a prospective cohort study of ...
Taşkınlar Hakan H Department of Pediatric Surgery, School of Medicine, Mersin University, Mersin, - - 2014
Although necrotizing enterocolitis (NEC) is a frequently encountered entity in premature infants in the neonatal intensive care unit, intussusception is extremely rare. Abdominal distension, bilious/non-bilious gastric residuals and bloody stool are the common clinical findings of both entities. Here we present three cases of intussusception misdiagnosed as NEC, two of ...
Edmonds Joyce K - - 2014
Cesarean birth is the most common surgical procedure in the United States and is associated with increased morbidity and mortality when compared to vaginal birth. Of the more than 4 million births a year, one in three is now a cesarean. A better understanding of the clinical indications contributing to ...
Pavić Dario - - 2014
There is strong evidence that the sex ratio at birth is partially determined by environmental and social factors. The modern change in those factors serves as an explanation for the secular decline in sex ratio at birth in most of the industrialized countries. This article is the reexamination of the ...
Yin Xiaojuan - - 2014
The aim was to investigate the surfactant protein B (SP-B) expression in the bronchoalveolar lavage fluid (BALF) of full-term neonates with respiratory distress syndrome (RDS). The enzyme-linked immunosorbent assay was performed to assess SP-B expression in BALF of 60 full-term neonates with RDS and 23 healthy neonates and correlation of ...
Nomura Shiho - - 2014
Preterm infants show transient hypothyroxinemia without thyroid-stimulating hormone (TSH) elevation. In addition, the degree of neurodevelopmental delay in preterm infants become severe according to the decreasing gestational age (GA). Because of the crucial role of thyroid hormones in brain development, hypothyroxinemia has the potential to cause developmental delay; however, the ...
Mekrungcharas Thanyaporn - - 2014
In Thailand, Iodine Deficiency Disorder (IDD) has been one of the most serious nutritional problems for over 50 years, especially for infants and young children. Iodine is an essential component of thyroid hormones, which are necessary for brain and body development especially during the first 2 years of life. During ...
Roberts Jessica K JK Division of Clinical Pharmacology, Department of Pediatrics, University of Utah School of Medicine, University of Utah Health Sciences Center, 295 Chipeta Way, Salt Lake City, UT, 84108, - - 2014
Antimicrobials and antivirals are widely used in young infants and neonates. These patients have historically been largely excluded from clinical trials and, as a consequence, the pharmacokinetics and pharmacodynamics of commonly used antibacterials, antifungals, and antivirals are incompletely understood in this population. This review summarizes the current literature specific to ...
- - 2014
Data from large randomized clinical trials indicate that therapeutic hypothermia, using either selective head cooling or systemic cooling, is an effective therapy for neonatal encephalopathy. Infants selected for cooling must meet the criteria outlined in published clinical trials. The implementation of cooling needs to be performed at centers that have ...
Autmizguine J - - 2014
Infants are therapeutic orphans. Many drugs used in infantsare used "off-label", increasing the risk of drug toxicity and suboptimal efficacy in this vulnerable population. This knowledge gap in clinical pharmacology is partly attributed to challenges associatedwith conducting clinical trials in infants. Consequently, there is a need for novel and efficient ...
Sola Augusto A President Ibero American Society of Neonatology - - 2014
Oxygen is a neonatal health hazard that should be avoided in clinical practice. In this review, an international team of neonatologists and nurses assessed oxygen saturation (SpO2 ) targeting in preterm infants and evaluated the potential weaknesses of randomised clinical trials. Conclusions SpO2 of 85-89% can increase mortality and 91-95% ...
Shankaran Seetha S Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI, 48201, USA, - - 2014
This article reviews the pathophysiology of hypoxic-ischemic brain injury, and the impact of hypothermia as neuroprotection in the clinical setting. The results of trials performed in well resourced and mid and low resourced countries is presented. Infant and childhood outcome following hypothermia is provided. Biomarkers of outcome that are clinical, ...
Honsel Maik M Paediatric and Neonatal Intensive Care Unit, Great Ormond Street Hospital for Children NHS Foundation Trust, - - 2014
Neuromuscular blocking agents (NMBA) are used in a range of critical illnesses in neonates and infants, despite a lack of guidelines and professional standards. This study reviewed the current evidence base and ascertained UK practice regarding the continuous use of these agents in this age range. We reviewed the literature ...
Small Susan A SA School of Audiology & Speech Sciences, University of British Columbia , Vancouver , - - 2014
Objective: To determine whether ipsilateral/contralateral asymmetries in the bone-conduction (BC) ASSR are robust enough in infants to be used clinically to isolate the test ear. Design: Retrospective investigation of three two-channel BC ASSR datasets. Subjects: Forty-eight adults (mean age 26.7 years), 49 infants (mean age 29.6 weeks). Methods: BC ASSR ...
Barnhart Kurt T KT Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address: - - 2014
Well-designed and -conducted clinical trials are needed to further advance the field for reproductive medicine. However, current reporting of outcomes of trials is ambiguous and disparate. In this review it is offered that the preferred outcome for clinical trials in reproductive medicine should be live birth. Multiple births should be ...
Aydın Halil Ibrahim HI Department of Pediatrics, Gülhane Military Medical Academy, Ankara. - - 2014
The aim in this study was to determine the factors affecting leptin and soluble leptin receptor (sOB-R) levels in term small for gestational age (SGA) and appropriate for gestational age (AGA) newborns. The study group consisted of SGA (n=20) and AGA (n=20) newborns and their mothers. The leptin and sOB-R ...
Van Noolen L L Département de Biochimie, Toxicologie et Pharmacologie, Institut de Biologie et Pathologie, CHU Grenoble, Grenoble, - - 2014
Vitamin B12 deficiency can lead to serious haematological and neurological signs in infants. The reported clinical cases of vitamin B12 deficiency were found in exclusively breast-fed infants whose asymptomatic mothers were diagnosed later with pernicious anaemia. For the infants, the diagnosis required urinary methylmalonic acid quantification (grossly elevated in these ...
Finkel Richard S RS Divisions of Neurology, Nemours Children's Hospital, Orlando, - - 2014
To determine the feasibility and safety of respiratory muscle function testing in weak infants with a progressive neuromuscular disorder. Respiratory insufficiency is the major cause of morbidity and mortality in infants with spinal muscular atrophy type I (SMA-I). Tests of respiratory muscle strength, endurance, and breathing patterns can be performed ...
Benkoe Thomas M TM Department of Pediatric Surgery, Medical University of Vienna, Austria. Electronic address: - - 2014
In recent years several potential biochemical markers have been evaluated to facilitate a reliable diagnosis of necrotizing enterocolitis (NEC), but none have made progress to clinical routine. We performed a comparative assessment in premature infants to evaluate the diagnostic value of the routinely available cytokine interleukin (IL)-8, and two promising ...
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