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Elder Dawn E - - 2013
Apnoea is defined as cessation of breathing with implicit pathophysiology. This review considers definitions of neonatal apnoea currently available and explores the evidence to support their use. For preterm and term infants, apnoea definitions appear arbitrary, are not supported by guidelines and vary from study to study. Although most alarms ...
Leibovitch Leah - - 2013
Background: Serotonin reuptake inhibitor (SRI) medications are commonly in use during pregnancy. Objectives: To evaluate short-term neonatal clinical signs among infants exposed to intrauterine SRI medications, in order to estimate the need for postnatal monitoring and observation. Methods: Retrospective review of clinical data in medical files of term infants born ...
Derman Y - - 2013
SUMMARY In Finland in April 2010, a 3-month old baby was diagnosed with type A infant botulism. He excreted botulinum neurotoxin and/or Clostridium botulinum in his faeces until November 2010. Five months of excretion was after clinical recovery and discharge from hospital. C. botulinum isolates recovered from the household dust ...
O'Connor Matthew C - - 2013
The National Institute for Health and Clinical Excellence neonatal jaundice guidelines recommend checking the bilirubin level in all infants with visible jaundice. The gold standard for this measurement is total serum bilirubin (TSB). Transcutaneous bilirubinometry (TcB) is an alternative to TSB that has been validated for clinical use through extensive ...
Erdemir Gulin - - 2013
BACKGROUND: Chorioamnionitis is closely related to premature birth and has negative effects on neonatal morbidity and mortality. METHODS: In this prospective study, 43 mothers who delivered earlier than 35 gestational weeks and their 57 infants were evaluated clinically and with laboratory findings. Placentas and umbilical cords were investigated histopathologically for ...
El-Khuffash Afif - - 2013
Background: Targeted milrinone treatment for low left ventricular output (LVO) reduces the incidence of acute cardiorespiratory instability following ligation of patent ductus arteriosus (PDA) in preterm infants. Despite this, some infants continue to experience postoperative deterioration. Adrenal insufficiency related to prematurity has been postulated as a possible mechanism. Objectives: To ...
Skotheim Siv - - 2013
The aim of the study was to investigate how young infants respond to contingent and non-contingent interaction in relation to maternal level of depressive symptoms in a non-clinical sample of mothers and infants. Two groups of three-month-olds interacted with their mother who was assessed as either non-depressed or sub-clinically depressed, ...
Gibbs N M - - 2013
BACKGROUND: /st>The mortality from perioperative anaphylaxis has recently been quoted in a range between 3 and 9%. However, it was our impression in Western Australia that we had had no deaths from perioperative anaphylaxis for over a decade. As we have comprehensive processes in place to investigate both perioperative anaphylaxis ...
Garfinkle Jarred - - 2013
BACKGROUND AND AIM: The benefits of therapeutic hypothermia have not been assessed from the perspective of the neurology clinic. We aimed to report the impact of the implementation of a local regional therapeutic hypothermia program on the neurodevelopmental outcomes of surviving hypoxic-ischemic encephalopathy (HIE) infants who were followed in the ...
Yin Xiaojuan - - 2013
Surfactant protein B (SP-B) deficiency has become increasingly recognized as a cause of severe prolonged respiratory distress. However, little has been reported with regard to the genetic variability of SP-B in Chinese infants with neonatal respiratory distress syndrome (RDS). One case of a Chinese male infant with neonatal RDS was ...
Uhm Kyeong Eun - - 2013
To determine the clinical characteristics and videofluoroscopic swallowing study (VFSS) findings in infants with suspected dysphagia and compare the clinical characteristics and VFSS findings between full-term and preterm infants. A total of 107 infants (67 full-term and 40 preterm) with suspected dysphagia who were referred for VFSS at a tertiary ...
Larson Austin - - 2013
Topical anesthetics are commonly used in many health care settings and for many clinical conditions. However, there are a number of potential adverse effects associated with their use. Their widespread administration can convey a false sense of security and failure to appreciate possible complications. We present the case of an ...
Streimish Iris - - 2013
Objective To assess the sensitivity and specificity of neutrophil CD64 as a diagnostic marker for clinical sepsis (based on a hematologic score) and as an additional marker with hematologic parameters for culture-proven sepsis in neonates.Study Design Prospective observational cohort over 18 months in a single-center neonatal intensive care unit.Results Hematologic ...
Murguía-Peniche Teresa - - 2013
The interplay between microorganisms and the intestine of newborn infants is associated with diverse functional and clinical outcomes that result from the specific interactions among microbial communities, their products, and the unique characteristics of the gastrointestinal tract. Multiple mechanisms of action for infant formula ingredients with probiotic activity appear to ...
Bodilis Hélène - - 2013
Bordetella pertussis isolates that do not express pertactin (PRN) are increasing in regions where acellular pertussis vaccines have been used for >7 years. We analyzed data from France and compared clinical symptoms among infants <6 months old infected by PRN-positive or PRN-negative isolates. No major clinical differences were found between ...
Naing Zin - - 2013
AIM: Premature neonates represent a population highly vulnerable to infection. This study aims to profile viral colonisation of gut and the associated clinical manifestations among premature neonates admitted to a neonatal intensive care unit (NICU) in Australia. METHODS: In a cohort of 75 premature neonates born at less than 32 ...
Ciliberto Heather - - 2013
Two infants developed hyperpigmented curvilinear patches on the posterior heel after wearing heel-length socks. Both of the patient's lesions improved after discontinuing the use of the heel-length socks. Hyperpigmented patches called sock-line or mitten-line hyperpigmentation have been reported at sites of tight elastic bands from socks or mittens in infants ...
Emerenciano Mariana - - 2013
Acute leukaemia in early childhood - and mainly infant leukaemia (IL) - is characterized by acquired genetic alterations, most commonly by the presence of distinct MLL rearrangements (MLL-r). The aim of this study was to investigate possible correlations between clinical features and molecular analyses of a series of 545 childhood ...
Kovacs Christopher S - - 2013
Recent research efforts have focused on the roles that vitamin D may play in skeletal and non-skeletal health during pregnancy, lactation, and fetal or neonatal development. Animal and clinical studies have shown that the mother provides calcium to the fetus and neonate without requiring vitamin D, calcitriol, or the vitamin ...
Shehabi Asem A - - 2013
BACKGROUND: Colonization of infants with MRSA carried specific toxin genes especially PVL are a risk factor for subsequent infection during hospitalization. This prospective study investigated important epidemiological characteristics of Staphylococcus aureus colonizing the nares and intestines of Jordanian infants. METHODS: A total of 860 nasal and stool specimens were obtained ...
Burge D M - - 2013
Reports on the management and outcome of rare conditions, such as oesophageal atresia, are frequently limited to case series reporting single-centre experience over many years. The aim of this study was to identify all infants born with oesophageal atresia in the UK and Ireland to describe current clinical practice and ...
Katheria A C - - 2013
Objective:To evaluate the hemodynamic changes occurring after rescue surfactant dosing in relation to the clinical respiratory response in preterm infants with respiratory distress syndrome.Study Design:We studied 20 infants who received surfactant (poractant alfa) after failing continuous positive airway pressure (CPAP) beyond 2 h of life. Consecutive echocardiograms were performed before the ...
Amin Sachin C SC Department of Pediatrics, Division of Neonatology, Center for Neonatal and Pediatric Gastrointestinal Disease, University of Illinois at Chicago, 840 South Wood Street, CSB 1257, Chicago, IL 60612, - - 2013
Short bowel syndrome (SBS) is the most common cause of intestinal failure in infants. In neonates and young infants, necrotizing enterocolitis, gastroschisis, intestinal atresia, and intestinal malrotation/volvulus are the leading causes of SBS. Following an acute postsurgical phase, the residual gastrointestinal tract adapts with reorganization of the crypt-villus histoarchitecture and ...
Farhath Sabeena - - 2013
Abstract: Objective: To study the relationship between pepsinogen/pepsin in a mouth swab and clinical gastroesophageal reflux (GER) in preterm infants. Methods: Preterm infants [birth weight (BW) ≤ 2000 grams] on full enteral feeds were enrolled. Mouth swabs from cheek and below the tongue were collected 1, 2 and 3 hours ...
Dilena Robertino - - 2013
Congenital myasthenic syndromes are inherited disorders caused by various defects in neuromuscular transmission. Although the typical presentation is fatigable weakness with prominent cranial involvement, neonates can lack these hallmark manifestations, and in those with choline acetyltransferase gene mutations, basal electrophysiological testing can yield negative findings. The authors report the case ...
Woods Patricia - - 2013
AIMS: The aim of the study was to examine the prevalence and management of outborn babies with a post-natally confirmed diagnosis of transposition of the great arteries (TGA) requiring transport by the Newborn and Paediatric Emergency Transport Service (NETS), New South Wales during the epoch 1991-2010. METHOD: A retrospective audit ...
Gutteridge Kathryn - - 2013
This article follows the journey of Sandwell and West Birmingham Hospitals NHS Trust quest for improving normal birth outcomes for a complex and diverse population. The opportunities that led to commissioning a colocated and freestanding birth centre are explored and how the design was influenced by less clinical beliefs about ...
Aggarwal Arun K - - 2013
This study was conducted to evaluate the performance of World Health Organisation (WHO) verbal autopsy tool in determining major causes of neonatal deaths. From a tertiary care hospital and a government multispecialty hospital, the attending paediatricians ascertained a clinical cause of death for 371 neonatal deaths. Trained field workers conducted ...
Moayedoddin A - - 2013
Depression and anxiety are major causes of distress amongst parents during the perinatal period. Their pervasive effects on the parents' self-confidence, on the parent-infant relationship and on the child's development have been well documented. The aims of the present study were to describe the psychological characteristics of mothers consulting during ...
Galinsky Robert - - 2013
Preterm birth is a major cause of perinatal mortality and long-term morbidity. Chorioamnionitis is a common cause of preterm birth. Clinical chorioamnionitis, characterised by maternal fever, leukocytosis, tachycardia, uterine tenderness, and preterm rupture of membranes, is less common than subclinical/histologic chorioamnionitis, which is asymptomatic and defined by inflammation of the ...
Schmölzer Georg M - - 2013
The main indications for interhospital neonatal transports are radiographic studies (e.g., magnet resonance imaging) and surgical interventions. Specialized neonatal transport teams need to be skilled in patient care, communication, and equipment management and extensively trained in resuscitation, stabilization, and transport of critically ill infants. However, there is increasing evidence that ...
Johnson Patricia J - - 2013
Normal sa line (NS) bolus infusions are indicated during resuscitation of the newborn to treat hypovolemia and resulting lactic acidosis because of inadequate tissue perfusion. However, in the neonatal intensive care settings, NS bolus infusions are also used to treat clinical hypoperfusion in the absence of confirmed volume loss or ...
Turrentine Mark A - - 2013
Background. Infants born to mothers who are colonized with group B streptococcus (GBS) but received <4 hours of intrapartum antibiotic prophylaxis (IAP) are at-risk for presenting later with sepsis. We assessed if <4 hours of maternal IAP for GBS are associated with an increased incidence of clinical neonatal sepsis. Materials ...
McCowan Lesley M E - - 2013
Small for gestational age (SGA) infants comprise up to 50% of all stillbirths and a minority are detected before birth. We aimed to develop and validate early pregnancy predictive models for SGA infants. 5628 participants from SCOPE, a prospective study of nulliparous pregnant women, were interviewed at 15±1 weeks' gestation. ...
Ozkan Aybars - - 2013
Uncontaminated urine samples are indispensable to precisely diagnose urinary tract infections in new-borns or infants. Among many clinical interventions for urine collection are described, the most common noninvasive practice is using sterile bags, associated with significant contamination of samples. In children, however, invasive methods i.e. catheterization, are generally needed for ...
Lista Gianluca - - 2013
Preterm infants with RDS need adequate resuscitation maneuvers and appropriate timing of surfactant replacement but about the latter there is not an universal consensus. A correct evaluation should consider at the same time the administration of antenatal steroids, the radiological criteria, the clinical presentation, the FiO2 level, OI and a/ApO2.
Vaccari Sabina - - 2013
Calcinosis cutis is a rare disorder resulting from the precipitation and deposition of insoluble calcium and phosphate salts (hydroxyapatite crystals) in the dermis and subcutaneous tissue. It is generally divided into four main groups on the basis of etiology and pathogenesis. Clinical presentation of cutaneous calcinosis cutis varies according to ...
Perenyi Agnes - - 2013
To assess the clinical usefulness of measurement of corpus callosum (CC) size in head ultrasound (HUS) to predict short-term neurodevelopmental (ND) outcomes in preterm infants. We hypothesised that including CC measurements in routine HUS will be an additional tool for early identification of infants at risk of adverse short-term ND ...
Pacifici Gian Maria GM Section of Pharmacology, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa 56100, Italy. - - 2013
Furosemide is the diuretic most used in newborn infants. It blocks the Na+-K+-2Cl- symporter in the thick ascending limb of the loop of Henle increasing urinary excretion of Na+ and Cl-. This article aimed to review the published data on the clinical pharmacology of furosemide in neonates to provide a ...
Wei Xufeng X Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland 21201, - - 2013
The infant Jarvik 2000 heart is a very small, hermetically sealed, intracorporeal, axial-flow ventricular assist device (VAD) designed for circulatory support in neonates and infants. The anatomic fit, short-term biocompatibility and hemodynamic performance of the device were evaluated in a neonate piglet model. The infant Jarvik 2000 heart with two ...
Abhyankar Swapna S National Library of Medicine, Bethesda, - - 2013
Knowledge about maternal history is critical for guiding certain aspects of newborn clinical care as well as for research on neonatal issues. However, often the only maternal history available in the newborn record is in the clinical notes. We are using data from the MIMIC-II database for a clinical study ...
Bekhof Jolita - - 2012
Late-onset neonatal sepsis (LOS) in preterm infants is an important cause of morbidity and mortality in preterm infants. Since presenting symptoms may be non-specific and subtle, early and correct diagnosis is challenging. We aimed to develop a nomogram based on clinical signs, to assess the likelihood of LOS in preterms ...
Tokumasu Hironobu - - 2012
BACKGROUND: Clinical chorioamnionitis and histological chorioamnionitis are important risk factors for neonatal complications and neurodevelopmental impairment in premature infants. However, it is unclear whether a diagnosis of clinical chorioamnionitis is sufficient to establish a diagnosis of histological chorioamnionitis. Here, we evaluated the predictive value of clinical chorioamnionitis in the diagnosis ...
van Thuijl Anders - - 2012
The double-blind placebo-controlled food challenge (DBPCFC) is currently the gold standard to diagnose cow's milk allergy (CMA). However, DBPCFCs are burdensome, expensive and require specialised facilities. For primary care physicians, selective and consistent referral to DBPCFC of infants suspected of CMA may be difficult. The objective of this study was ...
Schmölzer Georg M - - 2012
Tracheal intubation remains a common procedure during neonatal intensive care. Rapid confirmation of correct tube placement is important because tube malposition is associated with serious adverse outcomes. The current gold standard test to confirm tube position is a chest radiograph, however this is often delayed until after ventilation has commenced. ...
El-Khashab Mostafa - - 2012
Brain abscess in young infants is extremely rare and usually associated with a previous history of bacterial meningitis or septicemia. Here we report a cerebellar abscess mimicking brain tumor with atypical clinical and paraclinical presentations. A two-month old previously well-baby boy was referred to us with persistent vomiting, strabismus and ...
Shankaran Seetha - - 2012
This article covers the outcome of full-term infants with encephalopathy due to hypoxic-ischemia and pathophysiology of brain injury following hypoxic-ischemia. Clinical and imaging evidence for hypothermia for neuroprotection is presented. The outcome of infants with hypothermia for encephalopathy due to hypoxic-ischemia from recent trials is summarized. Facts regarding the clinical ...
Shore Richard M - - 2012
This is the continuation of a two-part review of rickets. This part emphasizes the specific pathophysiology, clinical features, pathoanatomy and radiographic findings of vitamin D deficiency rickets. Other forms of rickets, differential diagnostic considerations and the potential relationship between low levels of vitamin D metabolites and unexplained fractures in infants ...
Mussap M - - 2012
Despite a 35% decline in the mortality rate for infants aged <5 years over the past two decades, every year nearly 40% of all deaths in this age group occur in the neonatal period, defined as the first 28 days of life. New knowledge on molecular and biochemical pathways in ...
Ohishi Akira - - 2013
We report on a Filipino neonate with early onset and prolonged hyperbilirubinemia who was delivered by a vacuum extraction due to a prolonged labor. Subsequent studies revealed adrenal hemorrhage and glucose-6-phosphate dehydrogenase (G6PD) deficiency. It is likely that asphyxia and resultant hypoxia underlie the occurrence of adrenal hemorrhage and the ...
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