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Forner Gabriella G Department of Molecular Medicine, University of Padua, 35121 Padua , - - 2014
 To investigate the relationship between (1) the kinetics of CMV clearance in blood and urine and (2) the viral load in blood at birth and development of late-onset sequelae in asymptomatic congenital CMV infection.  33 newborns with congenital asymptomatic CMV infection born to women with primary CMV infection during pregnancy ...
Olabarrieta I I Department of Neonatology and Department of Pediatrics, Severo Ochoa Hospital, Leganés, Madrid, - - 2014
Respiratory viral infections are a major cause of hospitalisation in infants <1 year and might cause severe symptoms in preterm infants. Our aim was to analyse admissions due to respiratory infections in moderate, late and term infants, and to identify risk factors for hospitalisation in preterm versus term. Prospective study ...
Caserta Mary T MT Departments of Pediatrics, - - 2014
The goal of this study was to determine if congenital human herpesvirus-6 (HHV-6) infection influences early neurodevelopment. We enrolled 57 newborns with HHV-6 congenital infection and 242 control newborns without congenital infection into a prospective, double-blind study with 4 visits between 4 and 30 months of age. Assessments included the ...
AlFaleh K K Department of Pediatrics (Division of Neonatology), College of Medicine, King Saud University, Riyadh, Saudi - - 2014
To investigate the association of PRBC transfusion and the development of NEC in VLBW preterm infants at a tertiary care neonatal unit METHODS: A retrospective case-control study was performed. All VLBW infants'≤32 week and birth weight <1500 g born between 1999 and 2013 were included. Data were collected reviewing medical ...
Khatami A A The Children's Hospital at Westmead, Sydney, NSW, - - 2014
 Infections with human parechoviruses (HPeV) are associated with a wide range of clinical presentations in children, ranging from mild or asymptomatic infections to severe sepsis-like presentations or meningoencephalitis.  We reviewed medical records of infants admitted to 5 hospitals in NSW during an outbreak of HPeV-3 infection. Data were collected on ...
Leal Fabio E FE Washington DC, District of Columbia, United States ; - - 2014
HTLV-1, the first human retrovirus described, is the causative agent of a neglected disease affecting 5 - 10 million people worldwide. While often considered a lifelong asymptomatic disease, neurological complications including progressive neurodegeneration and an aggressive adult T-cell leukemia (ATL), which can arise in up to 10% of HTLV-1-infected individuals. ...
Ochoa Theresa J TJ Department of Pediatrics, Universidad Peruana Cayetano Heredia, Lima, Peru; Univeristy of Texas School of Public Health, Houston, Texas; Hospital Nacional Edgardo Rebagliati Martins, Lima, Peru; Instituto Nacional Materno Perinatal, Lima, Peru; Hospital Nacional Guillermo Almenara Irigoyen, Lima, Peru; Hospital Nacional Madre Niño San Bartolome, Lima, Peru; Abbott Laboratories, Lima, Peru; Universidad Peruana Cayetano Heredia, Lima, Peru; Instituto de Investigacion Nutricional, Lima, Peru - - 2014
We conducted a prospective cohort study in four hospitals in Lima, Peru in infants with a birth weight ≤ 1,500 g followed from birth hospital discharge up to 1 year of age to determine the incidence of respiratory syncytial virus (RSV) hospitalizations. We enrolled 222 infants from March of 2009 ...
Lejeune Alice A Pediatric Pulmonology/Immunology, Charité University Medical Center Berlin, Berlin, Germany, - - 2014
We report the course of dicygotic twins born preterm after 29 (4)/7 weeks of gestation due to congenital Parvovirus B19 infection causing fetal hydrops with severe anemia in one infant in whom intrauterine transfusion was impossible to perform and high levels of viremia in both infants. After being discharged, they were ...
Coffin Susan E SE Division of Infectious Diseases, Center for Pediatric Clinical Effectiveness, and Department of Infection Prevention, Children's Hospital of Philadelphia, Philadelphia, - - 2014
Objective. To develop a candidate definition for central line-associated bloodstream infection (CLABSI) in neonates with presumed mucosal barrier injury due to gastrointestinal (MBI-GI) conditions and to evaluate epidemiology and microbiology of MBI-GI CLABSI in infants. Design. Multicenter retrospective cohort study. Setting. Neonatal intensive care units from 14 US children's hospitals and pediatric facilities. ...
Pedersen Sarah H SH Division of Nutritional Sciences, Cornell University, Ithaca, New York, United States of - - 2014
Cryptosporidium epidemiology is poorly understood, but infection is suspected of contributing to childhood malnutrition and diarrhea-related mortality worldwide. A prospective cohort of 108 women and their infants in rural/semi-rural Tanzania were followed from delivery through six months. Cryptosporidium infection was determined in feces using modified Ziehl-Neelsen staining. Breastfeeding/infant feeding practices ...
Arruda Eurico E From the *University of São Paulo, School of Medicine, Cell Biology Department, Ribeirão Preto; †Pontifícia Universidade Católica do Rio Grande do Sul, School of Medicine, Infant Center, Biomedical Research Institute, Porto Alegre; ‡Federal University of Paraná, School of Medicine, Department of Pediatrics, Curitiba, Brazil; §AbbVie Inc., Medical Affairs, Virology, Buenos Aires, Argentina; ¶AbbVie Inc., Virology Global Project Team, Global Pharmaceutical Research and Development (GFN) and Global HEOR (PV), North Chicago, IL; and ‖Abbott Brazil, Medical Affairs, São Paulo, - - 2014
Respiratory syncytial virus (RSV) is associated with severe lower respiratory tract infection (LRTI), especially in preterm infants. Other viruses, co-detected with RSV, may play a role in the severity of respiratory outcomes. This prospective epidemiologic study of severe LRTI incidence among children born ≤35 weeks gestational age at 3 sites ...
Potočnjak Ines I Clinical Unit of Clinical Pharmacology and Toxicology, Clinical Hospital Centre Sestre milosrdnice, Zagreb, - - 2014
Congenital Cytomegalovirus (CMV) infection and alpha 1-antitrypsin (A1AT) deficiency are separately well described entities, but their simultaneous occurrence can pose a special challenge to a clinician, especially dealing with optimal diagnostic as well as therapeutic approach. Congenital CMV infection is the most common vertically transmitted infection in developed countries. In ...
Rangel Uesliz Vianna UV Instituto Fernandes Figueira, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, - - 2014
to relate the variables from a surveillance form for intravenous devices in high risk newborn infants with peripherally inserted central catheter related infection. approximately 15 variables were studied, being associated with peripherally inserted central catheter related infection, this being defined by blood culture results. The variables analyzed were obtained from ...
Perkins Meghan M Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, - - 2014
Maternal lead exposure is associated with poor birth outcomes in populations with moderate to high blood levels. However, no studies have looked at exposure levels commonly experienced by US women. We evaluated the relationship between maternal red blood cell (RBC) lead levels in midpregnancy and birth outcomes in 949 mother-child ...
Butler Karina M KM 1Department of Infectious Diseases and Immunology, Our Lady's Children's Hospital Crumlin, Dublin, Ireland 2University College Dublin, Ireland 3The National Virus Reference Laboratory, University College Dublin, Ireland 4The Coombe Women's Hospital, Dublin, Ireland 5Infection, Inflammation and Rheumatology, University College London, UK 6Department of Infection, University College London, - - 2014
Attention has focused on the possibility of cure for HIV infected infants if treated promptly following delivery. The 'Mississippi baby', who had very prolonged remission following ARV discontinuation, may represent a unique situation. We report an infant treated from birth, who seroreverted, remained virologically suppressed, and had undetectable HIV-1 RNA ...
Josephson Cassandra D CD Center for Transfusion and Cellular Therapies, Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, Georgia2Department of Pathology, Children's Healthcare of Atlanta, Atlanta, Georgia3Aflac Cancer Center and - - 2014
Postnatal cytomegalovirus (CMV) infection can cause serious morbidity and mortality in very low-birth-weight (VLBW) infants. The primary sources of postnatal CMV infection in this population are breast milk and blood transfusion. The current risks attributable to these vectors, as well as the efficacy of approaches to prevent CMV transmission, are ...
Nyati Mandisa M 1 Perinatal HIV Research Unit, Chris Hani Baragwanath Hospital and University of the Witwatersrand , Soweto, Gauteng, South Africa - - 2014
Abstract Objectives: Breastfeeding is accepted as the healthiest practice for human immunodeficiency virus (HIV)-infected infants, but decisions about infant feeding are made before the child's HIV status is known. We examined the feasibility of counseling to support breastfeeding for newly diagnosed HIV-infected infants, including relactation for those who had never ...
Charles Nwafor Chukwuemeka NC Department of Pathology, Federal Medical Centre, Umuahia Abia - - 2014
This study aimed to evaluate the mortality pattern in children seen at Federal Medical Centre Umuahia (FMCU) Abia state, South Eastern Nigeria. A retrospective cross sectional descriptive study over a 5-year period from January 1, 2004 to December 31, 2008 using data retrieved from the hospital's medical records department. A ...
Fichorova Raina N RN Laboratory of Genital Tract Biology, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, - - 2014
Gestational genitourinary infections are associated with lifelong disabilities, but it is unknown if neonatal inflammation is involved. Mothers of 914 infants born before 28th gestation week reported cervical/vaginal infection (CVI), and/or urine/bladder/kidney infection (UTI), or neither. Inflammation proteins measured in baby's blood on postnatal days 1, 7, and 14 were ...
Hecht Leah E LE Division of Genetics, Boston Children's Hospital, Boston, MA, 02115, USA, - - 2014
In the United States, and most developed nations, the newborn screening (NBS) panel covers many primary disorders of metabolism, including phenylketonuria (PKU). When an elevated phenylalanine level is identified, the infant is evaluated for PKU and should also be tested for tetrahydrobiopterin (BH4) deficiency. A neonate presented with a phenylalanine ...
Leung Angela M AM aDivision of Endocrinology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California bSection of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine, Boston, Massachusetts, - - 2014
This review will present a general overview of the sources, human studies, and proposed regulatory action regarding environmental perchlorate exposure. Some recent studies have reported significant associations between urinary perchlorate concentrations, thyroid dysfunction, and decreased infant intelligence quotient in groups who would be particularly susceptible to perchlorate effects. An update ...
Hoshino Tatsuji T Department of Obstetrics and Gynecology, Kobe City Medical Center General Hospital, Kobe, - - 2014
Congenital toxoplasmosis is caused by Toxoplasma gondii. The incidence of death due to congenital toxoplasmosis in Japan from 1974 to 2007 was calculated using the autopsy database of the Japanese Society of Pathology and vital statistics from the Ministry of Health, Labour and Welfare. Two neonatal deaths due to congenital ...
Bradley Heather H Division of STD Prevention, National Center for - - 2014
To describe the capacity of Peru's Perinatal Information System (Sistema Informático Perinatal, SIP) to provide estimates for monitoring the proportion of stillbirths and other adverse birth outcomes attributable to maternal syphilis. A descriptive study was conducted to assess the quality and completeness of SIP data from six Peruvian public hospitals ...
Sasi Arun A Monash Newborn, Monash Children's, Melbourne, Victoria, - - 2014
High flow nasal cannula therapy (HFNC) is an emerging method of non-invasive respiratory support therapy for premature infants. Recent evidence around its safety and efficacy for post-extubation respiratory support is encouraging. However, its effect on long-term respiratory outcomes is not known. The aim of this study is to determine the ...
Mittal Hema H Department of Paediatrics, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi, - - 2014
Fatal-disseminated Bacillus Calmette Guerin (BCG) disease is well known in infants with severe combined immunodeficiency after BCG vaccination. We report a 7 month male infant delivered as a product of in vitro fertilization and twin gestation that presented with fever, cough and multiple nodular skin lesions. A biopsy of skin ...
Gelfand Amy A AA Department of Neurology, Division of Child Neurology, University of California, San Francisco (UCSF), CA, USA Department of Neurology, Headache Center, University of California, San Francisco (UCSF), CA, USA - - 2014
Infant colic is a common and distressing disorder of early infancy. Its etiology is unknown, making treatment challenging. Several articles have suggested a link to migraine. The objective of this article was to perform a systematic review and, if appropriate, a meta-analysis of the studies on the relationship between infant ...
Fabrizio Cecilia S CS Global Health Associates, Hong - - 2014
As stunting moves to the forefront of the global agenda, there is substantial evidence that behaviour change interventions (BCI) can improve infant feeding practices and growth. However, this evidence has not been translated into improved outcomes on a national level because we do not know enough about what makes these ...
Byun Shin Yun SY Department of Pediatrics, Pusan National University School of Medicine, Yangsan, Republic of Korea. - - 2014
Cytomegalovirus (CMV) is currently the most common cause of congenital infection and the leading infectious cause of brain damage and hearing loss in children. Perinatal CMV infection rarely causes clinical manifestations in normal individuals and usually follows a benign course in immunocompetent infants. However, ~15-25% of infected preterm infants may ...
Kojima Katsuaki K Department of Pediatrics, 1Yokohama Municipal Citizens Hospital, Yokohama, Japan. - - 2014
We determined the predicting factors of early-onset group B streptococcal (EOGBS) infection in neonates who were born to GBS carrier mothers with inadequate intrapartum antibiotic prophylaxis (IAP). Medical records of all neonates born from January 1, 2008 to April 1, 2010 were reviewed. Inadequate IAP was defined as delivery less ...
Partridge J Colin JC Department of Pediatrics, University of California, San Francisco, Center for Clinical and Policy Perinatal Research, University of California, San - - 2014
Abstract Objective: Resuscitation of infants at 23 weeks' gestation remains controversial; clinical practices vary. We sought to investigate the cost effectiveness of resuscitation of infants born 23 0/7-23 6/7 weeks' gestation. Design: Decision-analytic modeling comparing universal and selective resuscitation to non-resuscitation for 5176 livebirths at 23 weeks in a theoretic ...
González-Bermúdez Carlos A CA Department of Food Science and Nutrition, Faculty of Veterinary Sciences, Regional Campus of International Excellence "Campus Mare Nostrum", University of Murcia, Spain. Electronic address: - - 2014
The effect of adding different thickening agents (locust bean gum (LBG), modified corn and rice starches (MCS, MRS)) to an infant formula on both in vitro mineral availability (Ca, Fe and Zn), quantified by atomic absorption spectrophotometry (AAS), and formula viscosity, after in vitro gastrointestinal digestion, was investigated. LBG was ...
Paech C C Department of Pediatric Cardiology, University of Leipzig-Heart Center, Leipzig, - - 2014
The use of dexamethasone in preterm infants developing bronchopulmonary dysplasia has been proven to be effective. Hypertrophic cardiomyopathy is a frequently reported, although transient, side effect of high-dose dexamethasone administration. The recent introduction of very low dexamethasone dose, called 'Minidex', promised equal effectiveness compared to high-dose dexamethasone without relevant side ...
Chang Young Pyo YP Department of Pediatrics, Dankook University College of Medicine, Cheonan, - - 2014
The use of glucocorticoids (GCs) in the perinatal period is suspected of being associated with adverse effects on long-term neurodevelopmental outcomes for preterm infants. Repeated administration of antenatal GCs to mothers at risk of preterm birth may adversely affect fetal growth and head circumference. Fetal exposure to excess GCs during ...
Cho Hwa Jin HJ Department of Pediatrics, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, South - - 2014
Congenital chylothorax is a rare condition, but it is the most common cause of pleural effusion in neonates and infants. Here, we report on the first trials of the intrapleural instillation of an extract of Viscum album (European mistletoe) (Abnobaviscum Q®) in two infants with congenital chylothorax that was refractory ...
Gizzi C C . - - 2014
Non invasive ventilation (NIV) is commonly used to treat RDS in preterm infants. Although less risky than invasive ventilation, NIV has some potential side effects and appropriate weaning is therefore desirable. However, criteria for the definition of stability prior to attempting NIV weaning as well as the best weaning strategies ...
Gargano G G . - - 2014
The aim of neonatal resuscitation is to establish an effective ventilation, avoiding lung damage. PEEP and T-piece use, as well as Sustained Lung Inflation, lower O2 target and appropriately timed surfactant administration analyzed. A new "gentle" respiratory approach in delivery room can improve newborn respiratory outcome.
Nijman Joppe J Department of Neonatology, University Medical Center, Utrecht, The - - 2014
Congenital cytomegalovirus infection is a leading cause of long-term sequelae. Cytomegalovirus is also frequently transmitted to preterm infants postnatally, but these infections are mostly asymptomatic. A correlation between cytomegalovirus genotypes and clinical manifestations has been reported previously in infants with congenital infection, but not in preterm infants with postnatal infection. ...
Amek Nyaguara O NO Center for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya; - - 2014
Assessing the progress in achieving the United Nation's Millennium Development Goals in terms of population health requires consistent and reliable information on cause-specific mortality, which is often rare in resource-constrained countries. Health and demographic surveillance systems (HDSS) have largely used medical personnel to review and assign likely causes of death ...
Salihu Hamisu M - - 2013
The objective of this paper is to review observational studies that addressed the survival of pre-viable gestations in the United States. We searched PubMed, Ovid, CINAHL, and Web of Knowledge for studies reporting survival of infants born at <24 gestational weeks and/or <500g in the United States and published between ...
Bialkowski Anja - - 2013
Background Pulmonary artery hypertension (PAH) is a significant cause of morbidity and mortality in infants with congenital diaphragmatic hernia (CDH). The phosphodiesterase-5 inhibitor sildenafil may be beneficial as a pulmonary vasodilator in CDH. Use of oral preparations of sildenafil may be restricted by feeding delays and intolerance. This study assessed ...
Takcı Sahin S Division of Neonatology, Hacettepe University Faculty of Medicine, Ankara, Turkey. - - 2013
Lamotrigine has been considered a safe new-generation antiepileptic drug during the perinatal period for both mothers and infants. Despite the concerns regarding its possible teratogenic effect, very limited data have been reported on the adverse effects of perinatal lamotrigine exposure. Herein, we report a case of an infant with hypotonicity ...
Vandeleest Jessica J JJ California National Primate Research Center, Davis, CA, USA. Electronic address: - - 2013
Birth timing, a relative measure of the timing of births within a season, has been shown to be related to the ways mothers and infant interact as well as to infant behavior and physiology. Although effects of birth timing on the hypothalamic-pituitary-adrenal (HPA) axis have previously been associated with variation ...
Powers Daniel A DA Population Research Center, University of Texas at Austin, United States. Electronic address: - - 2013
We investigate three interrelated sources of change in infant mortality rates over a 20year period using the National Center for Health Statistics (NCHS) linked birth and infant death cohort files. The effects of maternal age, maternal birth cohort, and time period of childbirth on infant mortality are estimated using a ...
Isaacs David - - 2013
Preterm infants are at increased risk of severe respiratory syncytial virus (RSV) infection. The monoclonal antibody palivizumab reduces the frequency of preterm infants being admitted to hospital with RSV infection. However, palivizumab is expensive, has to be given by intramuscular injection monthly for 5 months and has to be given ...
Caicedo Alexander - - 2013
Hypertensive disorders of pregnancy (HDP) are normally treated to avoid maternal complications. In this study we aimed to investigate if there was an effect of maternal HDP treatment on the cerebral autoregulation of the neonates by analysing measurements of mean arterial blood pressure (MABP) and rScO2 by means of correlation, ...
Maas A Janneke B M - - 2012
Research has shown that the early parent-infant relationship is of critical importance for children's developmental outcomes. While the effect of different settings on mother-infant interactive behavior is well studied, only few researchers systematically examined the effect of situational variables on mother-infant interaction. In the present study the effect of situational ...
Tran Lynn - - 2012
Necrotizing enterocolitis is the most common gastrointestinal emergency in neonates. The etiology is considered multifactorial. Risk factors include prematurity, enteral feeding, hypoxia, and bacterial colonization. The etiologic role of viruses is unclear. We present a case of necrotizing enterocolitis associated with cytomegalovirus and Proteobacteria in a 48-day-old, ex-premature infant and ...
Resch Bernhard B Bernhard Resch, Research Unit for Neonatal Infectious Diseases and Epidemiology, Division of Neonatology, Department of Paediatrics, Medical University of Graz, Austria, Auenbruggerplatz 30, 8036 Graz, - - 2012
Respiratory syncytial virus (RSV) is the most frequent and important cause of lower respiratory tract infection in infants and children. It is a seasonal virus, with peak rates of infection occurring annually in the cold season in temperate climates, and in the rainy season, as temperatures fall, in tropical climates. ...
Papoff Paola - - 2012
ABSTRACT: Although international guidelines for hemodynamic support of pediatric septic shock suggest considering the potent calcium sensitizer inodilator levosimendan as a second-line inotropic agent to treat cold hypodynamic shock resistant to catecholamines, clinical experience in septic infants is lacking. We report the beneficial effects of levosimendan infusion in 2 infants ...
McGhee Katie E - - 2012
1. Adaptive maternal programming occurs when mothers alter their offspring's phenotype in response to environmental information such that it improves offspring fitness. When a mother's environment is predictive of the conditions her offspring are likely to encounter, such transgenerational plasticity enables offspring to be better-prepared for this particular environment. However, ...
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