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Chikani Ugo N UN Department of Paediatrics, University of Nigeria Teaching Hospital, Ituku-Ozalla, Enugu, - - 2014
To determine the normative values of stretched penile length in apparently healthy term Igbo newborn males in South eastern Nigeria and its relationship with gestational age, birth weight and birth length. Eight hundred and eleven apparently healthy term male neonates within the first 72 h of life were studied. Enrolled subjects ...
Shi Xun X Dartmouth College, Hanover, NH, USA, - - 2014
There is increasing evidence of the role of arsenic in the etiology of adverse human reproductive outcomes. Because drinking water can be a major source of arsenic to pregnant women, the effect of arsenic exposure through drinking water on human birth may be revealed by a geospatial association between arsenic ...
Lean Wei Ling WL Neonatal Services, Royal Women's Hospital, Melbourne, Victoria, - - 2014
To describe the rate of early- and late-onset sepsis in neonates admitted to the neonatal intensive care unit at the Royal Women's Hospital and to compare the rate of late-onset sepsis (LOS) with a published (2008) cohort from the same unit. The secondary aim was to examine clinicians' compliance with ...
Christensen Robert D RD Women and Newborn's Clinical Program, Intermountain Healthcare, Salt Lake City, - - 2014
A recent NHLBI conference concluded that platelet (PLT) transfusions of neonates must become more evidence based. One neonatal disorder for which transfusions are given is a poorly defined entity, the "thrombocytopenia of perinatal asphyxia." To expand the evidence base for this entity, we performed a multicentered, retrospective analysis of neonates ...
Barak Sarit S Departments of Obstetrics and Gynecology, The Lis Maternity Hospital and the Dana Duek Children's Hospital, The Tel Aviv Medical Center, Tel Aviv, - - 2014
Objective The aim of this study is to examine the hypothesis that prolonged rupture of membranes (PROM) is associated with increased cord blood erythropoietin (EPO) concentrations, proportional to the duration of ruptured membranes. Study Design This study is a prospective, cross-sectional, observational (noninterventional) cohort study of mother-infant pairs. Criteria for inclusion were ...
Persaud Ryan R RR Faculty of Pharmacy, University of Manitoba, Winnipeg, Canada, R3E - - 2014
Abstract Objective: Describe neonatal antibiotic exposures occurring immediately before and after birth, and their associated risk factors. Methods: A retrospective review of the hospital charts of 449 mother-neonate pairs enrolled in the Canadian Healthy Infant Longitudinal Development (CHILD) national birth-cohort study was conducted at two tertiary hospitals and one rural ...
Ronchi Andrea A Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX; Neonatal Intensive Care Unit, Department of Clinical Sciences and Community Health, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, University of Milan, Milan, - - 2014
To determine the frequency of respiratory viral infections among infants who were evaluated for late-onset sepsis in the neonatal intensive care units (NICUs) of Parkland Memorial Hospital, Dallas, Texas; and Women & Infants Hospital, Providence, Rhode Island. Prospective cohort study conducted from January 15, 2012 to January 31, 2013. Infants ...
Natarajan Girija G Department of Pediatrics, Wayne State University, Detroit, - - 2014
The impact of timely empiric antimicrobial therapy on neonates is unclear. Our aim was to examine rates of effective timely empiric antimicrobial therapy on preterm neonates, together with the associated outcomes. We performed a single-centre retrospective study of preterm infants (< 32 weeks' gestational age) with a late-onset (>72 hours ...
Chakkarapani Elavazhagan E Neonatal Neuroscience, School of Clinical Medicine, St Michael's Hospital, University of Bristol, Bristol, - - 2014
Therapeutic hypothermia (HT) delays the cytokine response in infants with neonatal encephalopathy (NE). To determine if HT delayed the C-reactive protein (CRP) response and altered white blood cell (WBC), neutrophil and platelet count course during the first week of life in infants with NE. Retrospective cohort study. Regional neonatal intensive ...
Davari-Tanha Fatemeh F Department of Obstetrics and Gynecology, Women Hospital, Tehran University of Medical Sciences, Tehran, - - 2014
Elevated nucleated red blood cell (NRBC) count is introduced as a potential marker of intra-uterine growth restriction (IUGR). To investigate the probable association regardless of any known underlying disease, we aimed to study disturbances in NRBC count in infants experiencing idiopathic IUGR. Twenty three infants regarded IUGR without any known ...
Meier Emily Riehm ER Molecular Medicine Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, 20892; Center for Cancer and Blood Disorders, Children's National Medical Center, Washington, D.C, 20010; Department of Pediatrics, The George Washington University School of Medicine and Health Sciences, Washington, D.C, - - 2014
Prior analyses of the Cooperative Study of Sickle Cell Disease (CSSCD) newborn cohort identified elevated white blood cell (WBC) count, low baseline hemoglobin and dactylitis between the age 1 and 2 years as markers of severe disease. Reticulocytosis was also associated with severe disease. Here we further analyzed data collected ...
Patra Saikat S Department of Pediatrics, Kasturba Medical College, Manipal University, Manipal, 576104, Udupi District, Karnataka, India, - - 2014
Burkholderia cepacia is a rare cause of sepsis in newborns and its transmission involves human contact with heavily contaminated medical devices and disinfectants. The authors aimed to determine epidemiology, clinical features, antibiotic sensitivity pattern, complications and outcome of blood culture proven B. cepacia infections in 12 neonates. All neonates were ...
Kim Eun Na EN Department of Obstetrics and Gynecology, Seoul National University College of Medicine, 28 Yeongeon-dong, Chongno-gu, Seoul 110-744, Republic of - - 2014
Abstract Objective: Acute funisitis is a histologic hallmark of the fetal inflammatory response syndrome. This study was conducted to examine the hematologic profiles of preterm newborns with funisitis. Methods: The hematologic profiles of umbilical cord blood obtained at birth were compared according to the presence or absence of acute funisitis ...
Kakkar Fatima - - 2014
Reports of increased morbidity and mortality from infectious diseases among HIV Exposed Uninfected (HEU) infants have raised concern about a possible underlying immunodeficiency among them. The objective of this study was to assess the immunological profile of HEU infants born to mothers exhibiting different levels of HIV-1 viremia at the ...
Malloy M H MH Department of Pediatrics, University of Texas Medical Branch, Galveston, TX, - - 2014
Objective:Current American Academy of Pediatric recommendations call for the empirical use of antibiotics for all well-appearing term newborn infants born to women given a diagnosis of chorioamnionitis. The objective of this analysis was to determine among term infants (37-42 weeks gestation) the prevalence of exposure to clinical chorioamnionitis, intrapartum antibiotics, ...
Ma Liya L Southern Medical University, Guangdong Province, China; Department of Neonatology, Shenzhen Bao'an Maternal and Child Health Hospital, Guangdong Province, - - 2014
Immune status in the early life of preterm infants and its association with late onset infection has not been fully described. To investigate immune status of lymphocyte subsets in the first week in preterm neonates and its association with late onset infection, 143 preterm neonates (84 neonates ≤32 weeks, 59 ...
Ulm Lara N LN Washington University School of Medicine, Pediatrics, St. Louis, Missouri, United States ; - - 2014
ABSTRACT Rationale: Better phenotypic descriptions are needed for chronic lung disease among surviving premature infants. Objectives: The purpose of this study was to evaluate the potential usefulness of respiratory inductance plethysmography in characterizing respiratory system mechanics in preterm infants at 32 weeks post-menstrual age. Methods: Respiratory inductance plethysmography was used ...
Tewari Vishal Vishnu VV Neonatal Unit, Department of Pediatrics, Kerala Institute of Medical Sciences, Trivandrum, - - 2014
Background of the study: Neonates at risk for early-onset sepsis are started on antibiotics empirically. Antibiotic resistance to conventionally used antibiotics is increasingly being reported. Antenatal maternal antibiotic exposure in this setting contributes to low yield on blood culture drawn at birth, limiting the planning of antibiotics based on culture ...
Iwatani Sota S Department of Neonatology, Hyogo Prefectural Kobe Children's Hospital Perinatal Center, Kobe, - - 2014
Chorioamnionitis due to Candida species is relatively rare, despite the high prevalence (20-25%) of Candida vulvovaginitis during pregnancy. We describe a case of neonatal leukemoid reaction (NLR) associated with Candida albicans chorioamnionitis. A male infant was born at 31 weeks' gestation and weighed 1864 g. Laboratory tests at birth indicated marked ...
Khodayar-Pardo P P Pediatric Gastroenterology and Nutrition Section, Department of Pediatrics, University of Valencia, Hospital Clínico Universitario de Valencia, Valencia, - - 2014
Objective:There is an increasing evidence of the immunological role of breast milk (BM) microbiota on infant health. This study aims to analyze several determining factors of milk microbiota.Study Design:A total of 96 milk samples from 32 healthy mothers (19 preterm vs 13 at term gestations; and 15 vaginal deliveries vs ...
Remon J J 1] Division of Neonatology, Department of Pediatrics, University of Illinois at Chicago, Chicago, IL, USA  [2] Center for Neonatal and Pediatric Gastrointestinal Disease, Department of Pediatrics, University of Illinois at Chicago, Chicago, IL, - - 2014
Objective:Necrotizing enterocolitis (NEC) is characterized by macrophage infiltration into affected tissues. Because intestinal macrophages are derived from recruitment and in situ differentiation of blood monocytes in the gut mucosa, we hypothesized that increased recruitment of monocytes to the intestine during NEC reduces the blood monocyte concentration and that this fall in ...
Froom Paul P Regional Laboratory, Haifa and Western Galilee, Clalit Health Services , - - 2014
Criteria for peripheral smear review are designed to include those samples with results outside the reference interval and can be more extreme based on what is considered to have clinical utility. However, we are unaware of previous studies that reported the distributions of various complete blood cell count (CBC) parameters ...
Li H W Raymond HW Department of Obstetrics and Gynaecology, Centre of Assisted Reproduction and Embryology, Queen Mary Hospital, The University of Hong Kong , Hong - - 2014
Abstract This retrospective cohort study aims at determining whether baseline antral follicle count (AFC) and serum anti-Mullerian hormone (AMH) level in the index stimulation cycle predict live-birth outcome in subsequent frozen-thawed embryo transfer (FET) cycles. We studied 500 women undergoing the first IVF cycle who had embryo(s) cryopreserved. The main ...
Manicklal S S Division of Medical Virology, Department of Clinical Laboratory Sciences, University of Cape Town, Cape Town, South - - 2014
Background. A high rate of congenital CMV has been documented in HIV exposed infants in industrialized settings, both in pre- and post-HAART era. Only limited data on the birth prevalence of congenital CMV among infants of HIV-infected women on prenatal antiretroviral (ARV) prophylaxis are available from sub-Saharan Africa, despite a high ...
Lutsar Irja I University and University Clinics of Tartu, Tartu, Estonia, - - 2014
Late onset neonatal sepsis (LOS) has a high mortality and the optimal management is poorly defined. We aimed to evaluate new expert panel-derived criteria to define LOS and characterize the current management and antibiotic susceptibility of LOS-causing organisms in Europe. A prospective observational study enrolled infants aged 4 to 90 days ...
Caskey Melinda M Department of Pediatrics, Women & Infants Hospital, Providence, Rhode Island; - - 2014
The goal of this study was to test the association of mean adult word counts at 32 and 36 weeks' postmenstrual age in the NICU with Bayley Scales of Infant and Toddler Development, 3rd Edition (Bayley-III), cognitive and language scores. It was hypothesized that preterm infants exposed to higher word ...
Skinner Mark F MF Department of Archaeology, Simon Fraser University, Burnaby, BC, V5A 1S6, - - 2014
The goal of this study is to evaluate whether repetitive linear enamel hypoplasia (rLEH) in apes is ecologically informative. LEH, which appears as grooves of thinner enamel often caused by malnutrition and/or disease, is a permanent record of departures from developmental homeostasis in infant and juvenile apes. Orangutans were selected ...
Newman Thomas B TB aDepartments of Epidemiology and Biostatistics and Pediatrics, School of Medicine, University of California, San Francisco; bDivision of Research, Kaiser Permanente Northern California, Oakland, California; cDepartment of Applied Mathematics and Statistics, University of California, Santa Cruz, California; dDivision of Newborn Medicine, Children's Hospital, Boston, MA; eHarvard Medical School, Boston, MA; fDepartment of Newborn Medicine and Channing Laboratory, Brigham & Women's Hospital, Boston, MA ;and gDepartment of Inpatient Pediatrics, Kaiser Permanente Medical Center, Walnut Creek, - - 2014
The absolute neutrophil count and the immature/total neutrophil ratio (I/T) provide information about the risk of early-onset sepsis in newborns. However, it is not clear how to combine their potentially overlapping information into a single likelihood ratio. We obtained electronic records of blood cultures and of complete blood counts with ...
Odutola Aderonke A AA Vaccinology Theme, Medical Research Council Unit, Fajara, The - - 2014
To establish haematological and biological reference values for Gambian infants. Basic haematological and biochemical indices were analysed in blood samples obtained from healthy infants from Sukuta in the Western Division of The Gambia. The 2.5 and the 97.5 centiles for these indices were estimated. Reference ranges for haematological and biochemical ...
Maheshwari Akhil - - 2014
The aim is to review normal blood neutrophil concentrations and the clinical approach to neutropenia in the neonatal period. A literature search on neonatal neutropenia was performed using the databases PubMed, EMBASE, and Scopus, and the electronic archive of abstracts presented at the annual meetings of the Pediatric Academic Societies. ...
Bhat Ramesh Y RY Department of Paediatrics, Kasturba Medical College, Manipal, Karnataka, - - 2014
Neutropenia in infancy and childhood poses a diagnostic challenge as the aetiology ranges from acute life-threatening conditions to chronic benign diseases. Chronic benign neutropenia of infancy is a rare disorder occurring in 1:100 000. The neutrophil count continues to be low for a prolonged period until spontaneous resolution by the ...
Witzel Carsten - - 2014
The present study aims to compare metrical and morphological features of skeletal and dental development in two skeletons of very young infants from different archeological sites in Syria with the results of the microscopic approach of age-at-death estimation based on the neonatal line (NNL). Here, the presence ofa NNL is ...
Chan Grace J GJ Department of Medicine, Boston Children's Hospital, Boston, USA. - - 2014
We estimate the effect of antibiotics given in the intrapartum period on early-onset neonatal sepsis in Dhaka, Bangladesh using propensity score techniques. We followed 600 mother-newborn pairs as part of a cohort study at a maternity center in Dhaka. Some pregnant women received one dose of intravenous antibiotics during labor ...
Duvoisin Gilles G Service of Neonatology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland; - - 2014
Despite a low positive predictive value, diagnostic tests such as complete blood count (CBC) and C-reactive protein (CRP) are commonly used to evaluate whether infants with risk factors for early-onset neonatal sepsis (EOS) should be treated with antibiotics. We investigated the impact of implementing a protocol aiming at reducing the ...
Du Jikun J Department of Clinical Laboratory, Shenzhen Shajing Hospital Affiliated of Guangzhou Medical University, Shenzhen, - - 2014
Neutrophil CD64 has been proposed as an early marker of sepsis. This study aims to evaluate the diagnostic utility of neutrophil CD64 for identification of early-onset sepsis in preterm neonates. The prospective study was conducted in a neonatal intensive care unit between November 2010 and June 2011. Preterm neonates in ...
March Brayden B School of Medicine and Public Health, University of Newcastle, Newcastle, New South Wales, - - 2013
To describe the epidemiology of enteroviral meningoencephalitis in northern New South Wales, Australia, with a specific focus on neonatal and young infant cases. A retrospective review of PCR-confirmed enteroviral meningoencephalitis cases in the Hunter New England Local Health District of northern NSW was conducted for the period 2008-2012. One hundred ...
Laham James L JL From the *Division of Pediatric Critical Care Medicine, Department of Pediatrics, University of Kentucky Chandler Medical Center; †College of Public Health, Department of Biostatistics, ‡Pharmacy Services, University of Kentucky; and §Division of Neonatology, Department of Pediatrics, University of Kentucky Chandler Medical Center, Lexington, - - 2013
The aim of this study was to conduct a preliminary analysis of serum procalcitonin (PCT) to predict bacterial coinfection in infants with acute bronchiolitis. Retrospective cohort chart review of 40 infants admitted with acute bronchiolitis to the pediatric intensive care unit. Logistic regression models were used to determine the association ...
Albright A Leland AL Division of Neurosurgery, Department of Surgery, Kijabe Hospital, Kijabe, - - 2014
The authors undertook this study to determine white blood cell (WBC) counts in CSF obtained from lateral ventricles and myelomeningoceles (MMCs) in infants in a developing country at the time of their initial presentation for medical evaluation. CSF was aspirated from the lateral ventricles and from MMC sacs of 100 ...
Saha Aniket - - 2013
Acute lymphoblastic leukemia (ALL) in infants below 1 year of age accounts for 2.5% to 5% of childhood ALL. Most children with ALL present with fever, bruising, mucosal bleeding, bone pain, pallor, hepatosplenomegaly, and lymphadenopathy. Common sites of extramedullary involvement at diagnosis include liver, spleen, lymph nodes, brain, and testes. ...
Maheshwari Akhil - - 2013
The aim is to review normal blood neutrophil concentrations and the clinical approach to neutropenia in the neonatal period. A literature search on neonatal neutropenia was performed using the databases PubMed, EMBASE, and Scopus, and the electronic archive of abstracts presented at the annual meetings of the Pediatric Academic Societies. ...
Nicolai Ambra - - 2013
Preliminary results suggest that pertussis infection might be considered in infants during a seasonal respiratory syncytial virus (RSV) outbreak. In order to analyze clinical features and laboratory findings in infants with pertussis hospitalized for acute respiratory symptoms during a seasonal RSV outbreak we conducted a retrospective single-center study on 19 ...
Voramongkol Nipunporn N Department of Health, Ministry of Public Health, Nonthaburi, Thailand. - - 2013
The 2006 Thailand national prevention of mother-to-child transmission of HIV (PMTCT) guidelines recommended antiretroviral (ARV) regimen use during antenatal care (ANC) be based on CD4 results: highly active antiretroviral therapy (HAART) should be used for a CD4 < 200 cells/mm(3) and zidovudine/single-dose nevirapine should be used for a CD4 count ...
Mishra Jyoti Prakash - - 2013
Abstract Background: Neonatal morbidity due to neonatal jaundice is an alarming situation, which needs to be detected and managed at the earliest possible. Many different etiologies come into play together, and at times, it is difficult to isolate the cause of neonatal jaundice. Certain diagnostic tests such as hemoglobin levels, ...
Romero T - - 2013
The quality of colostrum of Murciano-Granadina goats was studied to establish the transition period and the time when milk can be marketed. Forty-three dairy goats were used: 19 primiparous (15 single births; 4 multiple births) and 24 multiparous (10 single births; 14 multiple births). Samples were collected every 12 h ...
Thorngate Lauren - - 2013
Amplitude-integrated EEG (aEEG) is increasingly used in research with premature infants; however, comprehensive interpretation is limited by the lack of simple approaches for reliably quantifying and summarizing the data. Explore operational measures for quantifying continuity and discontinuity, measured by aEEG as components of infant brain function. An exploratory naturalistic study ...
Imamura Takashi - - 2013
Because the role of eosinophils in neonates is not well understood, the clinical significance of eosinophilia in neonates is unclear. We encountered a rare case of cow's milk allergy in a premature male infant with severe eosinophilia in the neonatal period. The peripheral blood eosinophil count in this infant was ...
Majumdar Arijit A Department of Pathology and Bio Chemistry, Dr. Bidhan Chandra Roy Post Graduate Institute of Pediatric Sciences, Kolkata, West Bengal, - - 2013
Evaluation of the cerebrospinal fluid (CSF) white blood cell (WBC) count and glucose and protein concentrations is used to assess the probability of the presence of central nervous system (CNS) infection. Although normal values are well established for CSF cell counts and protein and glucose contents in children and adults, ...
Paul Siba P SP Specialty Trainee Year 5 in Paediatrics in the Department of Paediatrics, Yeovil District Hospital NHS Foundation Trust, Yeovil, - - 2013
A previously healthy 8-month-old boy presented to the emergency department with a 1-week history of chickenpox infection. His routine immunizations were up-to-date. His parents reported a high temperature (up to 39.5°C) in the preceding 48 hours and that he also had a mild cough, episodes of vomiting and loose stools. ...
Isik Dilek U - - 2013
Leukemoid reaction, defined as a total leukocyte count of >50,000/mm, is most commonly related to antenatal administration of steroids, infections, and transient myeloproliferative disorder of Down syndrome in newborns. Atypical presentations of viral infections can be a diagnostic challenge in the newborn period. Cytomegalovirus (CMV) infection causes a multisystem disease, ...
Vetter-Laracy S - - 2013
Objective:To evaluate the incidence, onset, duration, characteristics and importance of late-onset neutropenia (defined as absolute neutrophil count<1500 μl(-1) at 3 weeks of age or later) in a group of very low birth weight (VLBW) infants.Study design:Routine complete blood cell counts (CBCs) obtained from VLBW infants over a period of 7 years ...
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