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Ma Liya L Southern Medical University, Guangdong Province, China; Department of Neonatology, Shenzhen Bao'an Maternal and Child Health Hospital, Guangdong Province, - - 2014
Immune status in the early life of preterm infants and its association with late onset infection has not been fully described. To investigate immune status of lymphocyte subsets in the first week in preterm neonates and its association with late onset infection, 143 preterm neonates (84 neonates ≤32 weeks, 59 ...
Ulm Lara N LN Washington University School of Medicine, Pediatrics, St. Louis, Missouri, United States ; - - 2014
ABSTRACT Rationale: Better phenotypic descriptions are needed for chronic lung disease among surviving premature infants. Objectives: The purpose of this study was to evaluate the potential usefulness of respiratory inductance plethysmography in characterizing respiratory system mechanics in preterm infants at 32 weeks post-menstrual age. Methods: Respiratory inductance plethysmography was used ...
Tewari Vishal Vishnu VV Neonatal Unit, Department of Pediatrics, Kerala Institute of Medical Sciences, Trivandrum, - - 2014
Background of the study: Neonates at risk for early-onset sepsis are started on antibiotics empirically. Antibiotic resistance to conventionally used antibiotics is increasingly being reported. Antenatal maternal antibiotic exposure in this setting contributes to low yield on blood culture drawn at birth, limiting the planning of antibiotics based on culture ...
Iwatani Sota S Department of Neonatology, Hyogo Prefectural Kobe Children's Hospital Perinatal Center, Kobe, - - 2014
Chorioamnionitis due to Candida species is relatively rare, despite the high prevalence (20-25%) of Candida vulvovaginitis during pregnancy. We describe a case of neonatal leukemoid reaction (NLR) associated with Candida albicans chorioamnionitis. A male infant was born at 31 weeks' gestation and weighed 1864 g. Laboratory tests at birth indicated marked ...
Khodayar-Pardo P P Pediatric Gastroenterology and Nutrition Section, Department of Pediatrics, University of Valencia, Hospital Clínico Universitario de Valencia, Valencia, - - 2014
Objective:There is an increasing evidence of the immunological role of breast milk (BM) microbiota on infant health. This study aims to analyze several determining factors of milk microbiota.Study Design:A total of 96 milk samples from 32 healthy mothers (19 preterm vs 13 at term gestations; and 15 vaginal deliveries vs ...
Remon J J 1] Division of Neonatology, Department of Pediatrics, University of Illinois at Chicago, Chicago, IL, USA  [2] Center for Neonatal and Pediatric Gastrointestinal Disease, Department of Pediatrics, University of Illinois at Chicago, Chicago, IL, - - 2014
Objective:Necrotizing enterocolitis (NEC) is characterized by macrophage infiltration into affected tissues. Because intestinal macrophages are derived from recruitment and in situ differentiation of blood monocytes in the gut mucosa, we hypothesized that increased recruitment of monocytes to the intestine during NEC reduces the blood monocyte concentration and that this fall in ...
Froom Paul P Regional Laboratory, Haifa and Western Galilee, Clalit Health Services , - - 2014
Criteria for peripheral smear review are designed to include those samples with results outside the reference interval and can be more extreme based on what is considered to have clinical utility. However, we are unaware of previous studies that reported the distributions of various complete blood cell count (CBC) parameters ...
Li H W Raymond HW Department of Obstetrics and Gynaecology, Centre of Assisted Reproduction and Embryology, Queen Mary Hospital, The University of Hong Kong , Hong - - 2014
Abstract This retrospective cohort study aims at determining whether baseline antral follicle count (AFC) and serum anti-Mullerian hormone (AMH) level in the index stimulation cycle predict live-birth outcome in subsequent frozen-thawed embryo transfer (FET) cycles. We studied 500 women undergoing the first IVF cycle who had embryo(s) cryopreserved. The main ...
Manicklal S S Division of Medical Virology, Department of Clinical Laboratory Sciences, University of Cape Town, Cape Town, South - - 2014
Background. A high rate of congenital CMV has been documented in HIV exposed infants in industrialized settings, both in pre- and post-HAART era. Only limited data on the birth prevalence of congenital CMV among infants of HIV-infected women on prenatal antiretroviral (ARV) prophylaxis are available from sub-Saharan Africa, despite a high ...
Lutsar Irja I University and University Clinics of Tartu, Tartu, Estonia, - - 2014
Late onset neonatal sepsis (LOS) has a high mortality and the optimal management is poorly defined. We aimed to evaluate new expert panel-derived criteria to define LOS and characterize the current management and antibiotic susceptibility of LOS-causing organisms in Europe. A prospective observational study enrolled infants aged 4 to 90 days ...
Caskey Melinda M Department of Pediatrics, Women & Infants Hospital, Providence, Rhode Island; - - 2014
The goal of this study was to test the association of mean adult word counts at 32 and 36 weeks' postmenstrual age in the NICU with Bayley Scales of Infant and Toddler Development, 3rd Edition (Bayley-III), cognitive and language scores. It was hypothesized that preterm infants exposed to higher word ...
Skinner Mark F MF Department of Archaeology, Simon Fraser University, Burnaby, BC, V5A 1S6, - - 2014
The goal of this study is to evaluate whether repetitive linear enamel hypoplasia (rLEH) in apes is ecologically informative. LEH, which appears as grooves of thinner enamel often caused by malnutrition and/or disease, is a permanent record of departures from developmental homeostasis in infant and juvenile apes. Orangutans were selected ...
Newman Thomas B TB aDepartments of Epidemiology and Biostatistics and Pediatrics, School of Medicine, University of California, San Francisco; bDivision of Research, Kaiser Permanente Northern California, Oakland, California; cDepartment of Applied Mathematics and Statistics, University of California, Santa Cruz, California; dDivision of Newborn Medicine, Children's Hospital, Boston, MA; eHarvard Medical School, Boston, MA; fDepartment of Newborn Medicine and Channing Laboratory, Brigham & Women's Hospital, Boston, MA ;and gDepartment of Inpatient Pediatrics, Kaiser Permanente Medical Center, Walnut Creek, - - 2014
The absolute neutrophil count and the immature/total neutrophil ratio (I/T) provide information about the risk of early-onset sepsis in newborns. However, it is not clear how to combine their potentially overlapping information into a single likelihood ratio. We obtained electronic records of blood cultures and of complete blood counts with ...
Odutola Aderonke A AA Vaccinology Theme, Medical Research Council Unit, Fajara, The - - 2014
To establish haematological and biological reference values for Gambian infants. Basic haematological and biochemical indices were analysed in blood samples obtained from healthy infants from Sukuta in the Western Division of The Gambia. The 2.5 and the 97.5 centiles for these indices were estimated. Reference ranges for haematological and biochemical ...
Maheshwari Akhil - - 2014
The aim is to review normal blood neutrophil concentrations and the clinical approach to neutropenia in the neonatal period. A literature search on neonatal neutropenia was performed using the databases PubMed, EMBASE, and Scopus, and the electronic archive of abstracts presented at the annual meetings of the Pediatric Academic Societies. ...
Bhat Ramesh Y RY Department of Paediatrics, Kasturba Medical College, Manipal, Karnataka, - - 2014
Neutropenia in infancy and childhood poses a diagnostic challenge as the aetiology ranges from acute life-threatening conditions to chronic benign diseases. Chronic benign neutropenia of infancy is a rare disorder occurring in 1:100 000. The neutrophil count continues to be low for a prolonged period until spontaneous resolution by the ...
March Brayden B School of Medicine and Public Health, University of Newcastle, Newcastle, New South Wales, - - 2013
To describe the epidemiology of enteroviral meningoencephalitis in northern New South Wales, Australia, with a specific focus on neonatal and young infant cases. A retrospective review of PCR-confirmed enteroviral meningoencephalitis cases in the Hunter New England Local Health District of northern NSW was conducted for the period 2008-2012. One hundred ...
Laham James L JL From the *Division of Pediatric Critical Care Medicine, Department of Pediatrics, University of Kentucky Chandler Medical Center; †College of Public Health, Department of Biostatistics, ‡Pharmacy Services, University of Kentucky; and §Division of Neonatology, Department of Pediatrics, University of Kentucky Chandler Medical Center, Lexington, - - 2013
The aim of this study was to conduct a preliminary analysis of serum procalcitonin (PCT) to predict bacterial coinfection in infants with acute bronchiolitis. Retrospective cohort chart review of 40 infants admitted with acute bronchiolitis to the pediatric intensive care unit. Logistic regression models were used to determine the association ...
Albright A Leland AL Division of Neurosurgery, Department of Surgery, Kijabe Hospital, Kijabe, - - 2013
Object The authors undertook this study to determine white blood cell (WBC) counts in CSF obtained from lateral ventricles and myelomeningoceles (MMCs) in infants in a developing country at the time of their initial presentation for medical evaluation. Methods CSF was aspirated from the lateral ventricles and from MMC sacs ...
Saha Aniket - - 2013
Acute lymphoblastic leukemia (ALL) in infants below 1 year of age accounts for 2.5% to 5% of childhood ALL. Most children with ALL present with fever, bruising, mucosal bleeding, bone pain, pallor, hepatosplenomegaly, and lymphadenopathy. Common sites of extramedullary involvement at diagnosis include liver, spleen, lymph nodes, brain, and testes. ...
Maheshwari Akhil - - 2013
The aim is to review normal blood neutrophil concentrations and the clinical approach to neutropenia in the neonatal period. A literature search on neonatal neutropenia was performed using the databases PubMed, EMBASE, and Scopus, and the electronic archive of abstracts presented at the annual meetings of the Pediatric Academic Societies. ...
Nicolai Ambra - - 2013
Preliminary results suggest that pertussis infection might be considered in infants during a seasonal respiratory syncytial virus (RSV) outbreak. In order to analyze clinical features and laboratory findings in infants with pertussis hospitalized for acute respiratory symptoms during a seasonal RSV outbreak we conducted a retrospective single-center study on 19 ...
Voramongkol Nipunporn N Department of Health, Ministry of Public Health, Nonthaburi, Thailand. - - 2013
The 2006 Thailand national prevention of mother-to-child transmission of HIV (PMTCT) guidelines recommended antiretroviral (ARV) regimen use during antenatal care (ANC) be based on CD4 results: highly active antiretroviral therapy (HAART) should be used for a CD4 < 200 cells/mm(3) and zidovudine/single-dose nevirapine should be used for a CD4 count ...
Mishra Jyoti Prakash - - 2013
Abstract Background: Neonatal morbidity due to neonatal jaundice is an alarming situation, which needs to be detected and managed at the earliest possible. Many different etiologies come into play together, and at times, it is difficult to isolate the cause of neonatal jaundice. Certain diagnostic tests such as hemoglobin levels, ...
Romero T - - 2013
The quality of colostrum of Murciano-Granadina goats was studied to establish the transition period and the time when milk can be marketed. Forty-three dairy goats were used: 19 primiparous (15 single births; 4 multiple births) and 24 multiparous (10 single births; 14 multiple births). Samples were collected every 12 h ...
Thorngate Lauren - - 2013
Amplitude-integrated EEG (aEEG) is increasingly used in research with premature infants; however, comprehensive interpretation is limited by the lack of simple approaches for reliably quantifying and summarizing the data. Explore operational measures for quantifying continuity and discontinuity, measured by aEEG as components of infant brain function. An exploratory naturalistic study ...
Imamura Takashi - - 2013
Because the role of eosinophils in neonates is not well understood, the clinical significance of eosinophilia in neonates is unclear. We encountered a rare case of cow's milk allergy in a premature male infant with severe eosinophilia in the neonatal period. The peripheral blood eosinophil count in this infant was ...
Majumdar Arijit A Department of Pathology and Bio Chemistry, Dr. Bidhan Chandra Roy Post Graduate Institute of Pediatric Sciences, Kolkata, West Bengal, - - 2013
Evaluation of the cerebrospinal fluid (CSF) white blood cell (WBC) count and glucose and protein concentrations is used to assess the probability of the presence of central nervous system (CNS) infection. Although normal values are well established for CSF cell counts and protein and glucose contents in children and adults, ...
Paul Siba P SP Specialty Trainee Year 5 in Paediatrics in the Department of Paediatrics, Yeovil District Hospital NHS Foundation Trust, Yeovil, - - 2013
A previously healthy 8-month-old boy presented to the emergency department with a 1-week history of chickenpox infection. His routine immunizations were up-to-date. His parents reported a high temperature (up to 39.5°C) in the preceding 48 hours and that he also had a mild cough, episodes of vomiting and loose stools. ...
Isik Dilek U - - 2013
Leukemoid reaction, defined as a total leukocyte count of >50,000/mm, is most commonly related to antenatal administration of steroids, infections, and transient myeloproliferative disorder of Down syndrome in newborns. Atypical presentations of viral infections can be a diagnostic challenge in the newborn period. Cytomegalovirus (CMV) infection causes a multisystem disease, ...
Vetter-Laracy S - - 2013
Objective:To evaluate the incidence, onset, duration, characteristics and importance of late-onset neutropenia (defined as absolute neutrophil count<1500 μl(-1) at 3 weeks of age or later) in a group of very low birth weight (VLBW) infants.Study design:Routine complete blood cell counts (CBCs) obtained from VLBW infants over a period of 7 years ...
Lacaze-Masmonteil Thierry - - 2013
To evaluate the usefulness of a single C-Reactive Protein (CRP) measurement at 18 h of age to identify neonates where antibiotics started for possible early onset sepsis (EOS) could safely be discontinued. In a prospective cohort of 647 preterm (<35 weeks) and 555 late preterm (35-36 weeks) or term newborns ...
Ozkan Hilal - - 2013
The aim of this study was to determine the causative agents in early-, late- and very late-onset sepsis in preterm infants. The demographic features, risk factors, clinical and laboratory findings in sepsis types were also defined. A total of 151 preterm infants with culture-proven neonatal sepsis were enrolled in this ...
Mardaneh Jalal J Department. of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran ; Prof. Alborzi Clinical Microbiology Research Center, Shiraz University of Medical Sciences, Shiraz, - - 2013
Pantoea agglomerans is a Gram-negative rod in the Enterobacteriaceae family. It is reported as both commensal and opportunistic pathogen of animals and humans. This organism is potential candidates as powdered infant milk formula-borne opportunistic pathogen. The aim of our study was to perform isolation, identification and antimicrobial susceptibility pattern of ...
Bhatia Risha - - 2013
Background: Very preterm infants can be treated with nasal continuous positive airway pressure (CPAP) from birth, but some fail. A rapid test, such as the stable microbubble test (SMT) on gastric aspirate, may identify those who can be managed successfully using CPAP. Objective: To determine if SMT can identify soon ...
Saleem Ali Faisal - - 2013
Objective: To determine the clinico-demographic features and laboratory parameters of children with severe combined immunodeficiency (SCID). Study Design: Case series. Place and Duration of Study: Department of Paediatrics and Child Health, the Aga Khan University, Karachi, from July 2006 to July 2011. Methodology: Thirteen infants who were discharged with a ...
Ferrer-Marin Francisca - - 2013
Thrombocytopenia is a common problem among sick neonates admitted to the neonatal intensive care unit. Among neonates, preterm infants are the subgroup at highest risk for thrombocytopenia and hemorrhage, which is frequently intracranial. Although there is no evidence of a relationship between platelet (PLT) count and occurrence of major hemorrhage, ...
Li Jingang - - 2013
Background: Raised nucleated red blood cell (NRBC) counts in neonates may indicate in utero hypoxia and brain damage. Objective: The study aimed to examine the use of NRBC counts as a predictor of brain injury and neurodevelopmental outcomes in neonates with hypoxic-ischemic encephalopathy (HIE) treated under current cooling-based strategy. Methods: ...
Patidar Shailendra S Department of Pediatrics, Gandhi Medical College and Kamla Nehru Hospital, Bhopal, Madhya Pradesh, - - 2013
Hematological values of the newborn babies vary according to the gestational age and intrauterine growth. The objective of this study is to compare the iron status and red cell parameters in healthy term small for gestational age (SGA) and appropriate for gestational age (AGA) neonates. A prospective hospital based study ...
Jenssen Håvard Bjørke - - 2013
BackgroundWhile iron deficiency is rendered the leading cause of anemia in infants, cobalamin deficiency is foremost characterized by developmental delay, and the typical macrocytic anemia is confined to severe and longstanding cobalamin deficiency in this age group. Hematological parameters were investigated in 4 months old infants with biochemical signs of ...
Markic Josko - - 2013
Early recognition of serious bacterial infection (SBI) in children is essential for better treatment outcome. Flow cytometry analysis of neutrophil surface molecules has been more frequently utilized as a tool for diagnosis of infection. The infants (n = 105) under 6 months of age presenting to the pediatric emergency department with fever without ...
Suksumek Nithipun N Division of Neonatology, Department of Pediatrics, Faculty of Medicine, University of Calgary, Calgary, Alberta, - - 2013
Intraventricular hemorrhage with congenital cytomegalovirus (CMV) infection is rare and has been reported only in extremely premature infants or in association with thrombocytopenia. We report the first case of a full-term male infant with congenital CMV infection and intraventricular hemorrhage with a normal platelet count and coagulation profile. The infant ...
Woo Se Joon - - 2013
To investigate the relationship between cytokine levels in cord blood and perinatal factors and retinopathy of prematurity (ROP) in gestational age-matched, preterm, newborn infants. Each of 20 premature singleton infants with ROP (gestational age < 32 weeks) was matched for gestational age, birth weight, and sex with two control infants ...
Cook Cathleen - - 2013
We report a 4-month-old male presenting with hypocalcemia, hyperleukocytosis, and newly diagnosed acute myeloid leukemia. He received chemical leukoreduction through low-dosed cytarabine, with appropriate decrease in his white blood cell count and development of subsequent symptomatic hypocalcemia, which did not normalize until the underlying vitamin D deficiency was addressed. A ...
Rwebembera Anath - - 2013
Vitamin D is essential for bone development and may also play an integral role in control of intracellular pathogens. Serum 25-hydroxyvitamin D levels were assessed at 6 months of age for 191 HIV-exposed uninfected infants enrolled in a trial of multivitamins (not including vitamin D) in Tanzania. A total of ...
Freyne Bridget - - 2013
Background. Serious bacterial illness (SBI) presents a diagnostic challenge in febrile infants. History, clinical signs, and laboratory information combined with experiential knowledge affects decisions to admit and treat. Aim. To assess the utility of serum procalcitonin and the Acute Infantile Observation Score (AIOS) performed at emergency department presentation in predicting ...
Zhao Qiuhong - - 2013
OBJECTIVES: To design a predictive model for assessing the risk of developing respiratory distress syndrome (RDS) using gestational age (GA) and lamellar body counts (LBC). DESIGN AND METHODS: LBCs and patient outcome data was obtained from five medical centers. A total of 223 patients were included in this study; 19 ...
Alicea-Serrano Angela M - - 2013
Newborns acquire their first microbiota at birth. Maternal vaginal or skin bacteria colonize newborns delivered vaginally or by C-section, respectively (Dominguez-Bello et al. 2010 #884). We aimed to determine differences in the presence of four tetracycline (tet) resistance genes, in the microbes of ten newborns and in the mouth and ...
Kourtis Athena P - - 2013
: To evaluate severe (grade 3/4) morbidity and mortality in HIV-exposed, uninfected infants. : Secondary data analysis of The Breastfeeding, Antiretrovirals, and Nutrition (BAN) clinical trial. : BAN randomized 2369 mother-infant pairs to maternal, infant, or no extended antiretroviral prophylaxis during breastfeeding. Morbidity outcomes examined were pneumonia/serious febrile illness, diarrhea/growth ...
Pozo-Rubio Tamara - - 2013
Introduction: It is known that the HLA genotype can explain about a 40% of the genetic risk of celiac disease (CD), thus, other genetic predisposing factors as well as factors that subtly modulate T cell activation and differentiation need to be studied. This includes environmental factors that are currently believed ...
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