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Kumwenda Newton I - - 2012
Data on paediatric reference laboratory values are limited for sub-Saharan Africa. To describe the distribution of haematological and chemical pathology values among healthy infants from Malawi and Uganda. A cross-sectional study was conducted among healthy infants, 0-6 months old, born to HIV-uninfected mothers recruited from two settings in Blantyre, Malawi ...
Nishijo Muneko - - 2012
Dioxin exposure levels remain elevated in residents living around former US Air Force bases in Vietnam, indicating potential adverse impacts on infant growth. In this study, 210 mother-infant pairs in dioxin-contaminated areas in Vietnam were recruited at the infants' birth and followed up for 4 months. Perinatal dioxin exposure levels ...
Morales Diego M - - 2012
Neurological outcomes of preterm infants with posthemorrhagic hydrocephalus are among the worst in newborn medicine. There remains no consensus regarding the diagnosis or treatment of posthemorrhagic hydrocephalus, and the pathological pathways leading to the adverse neurological sequelae are poorly understood. In the current study, we developed an innovative approach to ...
Lebensburger Jeffrey D - - 2012
Clinical complications of sickle cell anemia begin in infancy. BABY HUG (ClinicalTrials.gov, NCT00006400) was a NHLBI-NICHD supported randomized phase III placebo-controlled trial of hydroxyurea (HU) in infants (recruited at 9-18 months) unselected for clinical severity with sickle cell anemia. This secondary analysis of data from BABY HUG examines the influence ...
Black Allison - - 2012
Human neonates are at significantly greater risk of serious infection than immunocompetent adults. In particular, very low birth weight infants in the neonatal intensive care nursery are at high risk of developing life-threatening bacterial and fungal infections. Recent studies have identified Th17 cells as critical mediators of immunity to bacterial ...
Puck Jennifer M JM Department of Pediatrics, University of California San Francisco, San Francisco, California, USA. - - 2011
Early detection of primary immunodeficiency is recognized as important for avoiding infectious complications that compromise outcomes. In particular, severe combined immunodeficiency (SCID) is fatal in infancy unless affected infants can be diagnosed before the onset of devastating infections and provided with an immune system through allogenic hematopoietic cell transplantation, enzyme ...
Verbsky James W - - 2011
Severe combined immunodeficiency is a life-threatening primary immune deficiency characterized by low numbers of naïve T cells. Early diagnosis and treatment of this disease decreases mortality. In 2008, Wisconsin began newborn screening of infants for severe combined immunodeficiency and other forms of T-cell lymphopenia by the T-cell receptor excision circle ...
Hikino Shunji - - 2011
Background:  Bronchopulmonary dysplasia (BPD) occurs in association with prenatal conditions predisposing infants to inflammation and remodeling of the premature lungs. Because of no useful biomarkers of BPD, we analyzed the gene expressions in tracheal aspirate fluid (TAF) cells of premature infants. Methods:  Of 148 consecutive patients, 26 preterm infants (gestational ...
Chase Nicole M - - 2011
Over the past three years, newborn blood screening (NBS) for severe T cell lymphopenia/severe combined immunodeficiency (sTCL/SCID) using the T cell receptor excision circle (TREC) assay has revolutionized the early detection of infants with primary immunodeficiencies (PIDs) associated with T cell lymphopenia. Nonetheless, despite the comprehensive NBS protocols developed by ...
van der Aa L B - - 2011
BACKGROUND: In a murine model of allergic inflammation, Bifidobacterium breve M-16V has been shown to reduce IL-4 and IgE by inducing IL-10 and IFN-γ. However, it remains unknown whether this strain has the same effect in humans with allergic disease. OBJECTIVE: To determine the effects of Bifidobacterium breve M-16V combined ...
Farquhar Carey C Department of Medicine, University of Washington, Seattle 98104-2499, USA. - - 2011
Although evidence supports a relationship between human immunodeficiency virus (HIV)-1 exposure and HIV-1-specific CD8(+) T cell responses, studies have not demonstrated a direct association between the quantity of HIV-1 to which a person is exposed and the presence or absence of a response. From 1999 to 2005, maternal HIV-1 RNA ...
Kubo Masako - - 2011
Renal cell carcinoma (RCC) associated with tuberous sclerosis (TSC) has been reported in adult patients; however, this association is rare in children. We have encountered 2 different types of RCCs in infants who developed TSC later in childhood. The pathologic diagnoses were papillary RCC in one infant and a clear ...
Urquia Marcelo Luis - - 2011
Immigrants' health is jointly influenced by their pre- and post-migration exposures, but how these two influences operate with increasing duration of residence has not been well-researched. We aimed to examine how the influence of maternal country of birth and neighborhood deprivation effects, if any, change over time since migration and ...
Rath M E A - - 2011
Objective  To evaluate the incidence and severity of and risk factors for thrombocytopenia at birth in neonates with red cell alloimmunization. Study design  All neonates with haemolytic disease of the foetus/newborn (HDFN) due to red cell alloimmunization admitted to our centre between January 2000 and September 2010 were included in ...
Sim Ji Hyun - - 2011
Dermatomyofibroma is a rare benign cutaneous mesenchymal neoplasm of the fibroblasts and myofibroblasts. The majority of dermatomyofibromas present as red-brown discolored plaques or nodules, commonly located on the shoulder, upper arm, axilla, neck, and/or upper trunk. These lesions develop most frequently in young female patients at a mean of 28-years-of-age. ...
Mazzola Taís N - - 2011
OBJECTIVE:: To evaluate cell-mediated immune response to Bacillus Calmette-Guérin (BCG) vaccination in uninfected, HIV-1-exposed infants, comparing it to unexposed children. DESIGN:: Cross-sectional study. METHODS:: BCG-specific lymphoproliferation and T cell subsets (CD4, CD8 and TCR γδ) by flow cytometry and IL-10, IFN-γ and TNF-α concentration by ELISA were analyzed in HIV-exposed ...
Lönnerdal Bo - - 2011
OBJECTIVES:: Human lactoferrin (hLF), a major protein in human milk, has been shown to exert multiple biological activities. To achieve some of the benefits of breast-fed infants, we therefore investigate the feasibility of adding commercially available bovine LF (CbLF) to infant formula. SUBJECTS AND METHODS:: An intestinal enterocyte model (Caco-2 ...
Wykes Clare - - 2011
Evaluation of: Wang WC, Ware RE, Miller ST et al. Hydroxycarbamide in very young children with sickle-cell anaemia: a multicentre, randomised, controlled trial (BABY HUG). Lancet 377(9778), 1663-1672 (2011). The BABYHUG study is the first randomized controlled prospective trial of hydroxycarbamide in infants with sickle cell anemia to look at ...
Elabiad Mohamad T - - 2011
Objectives: To assess whether blood transfusions for infants with birth weights of 1000 g or less are a source of mercury and whether any mercury delivered through the transfusion is above the currently set oral reference dose. Patients and Methods: We studied an observational cohort. Inclusion criteria included birth weight ...
Belhocine Wahib - - 2011
To cite this article: Belhocine W, Ibrahim Z, Grandné V, Buffat C, Robert P, Gras D, Cleach I, Bongrand P, Carayon P, Vitte J. Total serum tryptase levels are higher in young infants. Pediatr Allergy Immunol 2011: Doi: 10.1111/j.1399-3038.2011.01166.x. ABSTRACT: Background:  Mast cells participate in immune defense and allergic disease. ...
Amatuzzi Monica - - 2011
Premature birth is a well-known risk factor for sensorineural hearing loss in general and auditory neuropathy in particular. However, relatively little is known about the underlying causes, in part because there are so few relevant histopathological studies. Here, we report on the analysis of hair cell loss patterns in 54 ...
Quah P L - - 2011
Background Neonates with a family history of atopy are at higher risk for developing wheezing in early life. Objective From a birth cohort of at risk infants (first-degree family with atopic disease), we evaluated the influence of distinct intrinsic immunologic risk factors on wheezing disorders in the first 2 years ...
Karasik Lana B LB New York University, New York, NY 10003, USA. - - 2011
Associations between infants' transition to walking and object activities were examined. Fifty infants were observed longitudinally during home observations. At 11 months, all infants were crawlers; at 13 months, half became walkers. Over age, infants increased their total time with objects and frequency of sharing objects with mothers. Bidirectional influences ...
Kato Toru - - 2011
OBJECTIVE: To investigate the accuracy of conventional electroencephalograms (cEEGs) and amplitude-integrated EEGs (aEEGs) in the evaluation of brain maturation in normal pre-term infants. In addition, extrauterine acceleration of brain maturation was investigated. METHODS: A total of 129 EEGs recorded between 27 and 37weeks of postconceptional age (PCA) from 37 clinically ...
Watanabe Hama - - 2011
In young infants, activation or inhibition of body movements on perception of environmental events is important to enable them to act on the world or understand the world. To reveal the development of this ability, we observed movement patterns in all four limbs under the two experimental conditions. Infants assigned ...
George Isabel - - 2011
To document trends and covariates of creatinemia (Scr) in extremely low birth weight (ELBW, < 1,000 g) neonates, maternal characteristics [betamethasone, premature preterm rupture of membranes (PPROM), pre-eclampsia, maternal Scr], characteristics at delivery [gestational age (GA), birth weight (BW), small for GA (SGA), Apgar, intubation] and during neonatal stay [ventilation, ...
Monteagudo B - - 2011
At birth, vernix caseosa can cover the whole body surface or accumulate only on the back and in the skin folds. Interest in its composition and function and its possible applications in adults has increased in recent years. The objective of this study was to determine the prevalence of vernix ...
Lopez Emmanuel - - 2011
BACKGROUND: In adult patients with chronic obstructive pulmonary disease, there is a gradient between end-tidal carbon dioxide (EtCO(2) ) and arterial carbon dioxide pressure (PaCO(2) ), and the slope of the ascending phase of the capnogram is decreased due to obstruction. Corresponding data are lacking in infants with bronchopulmonary dysplasia ...
Beauchamp Josée N - - 2011
OBJECTIVES:: In a prior retrospective analysis of 32 infants diagnosed with cow's-milk protein-induced enterocolitis (CMPIE), gastrointestinal (GI) symptoms were observed with the introduction of milk-free infant cereal. The aim of this randomized controlled trial was to compare the incidence of new GI symptoms with the introduction of either milk-free infant ...
Chadwick Sara L SL Department of Infectious Diseases and Microbiology, Graduate School of Public Health, Pittsburgh, PA, - - 2011
BACKGROUND This study describes differences in the values of cerebrospinal fluid (CSF) white blood cell (WBC), glucose, and protein counts in infants less than 60 days of age with fever who were not proven to have viral or bacterial meningitis. Three independent retrospective medical record reviews were conducted using a ...
Drossard Claudia - - 2011
PURPOSE: Anthocyanins, a colourful group of flavonoids in many fruits and vegetables, are proposed to provide positive impact on human health. However, intake estimations have almost exclusively been conducted in adult populations. As infants and toddlers are a promising age group for health promotion, we examined their anthocyanin intake (as ...
Auriti Cinzia - - 2011
Objective To investigate the accuracy of procalcitonin (PCT) as a diagnostic marker of nosocomial sepsis (NS) and define the most accurate cut-off to distinguish infected from uninfected neonates. Setting Six neonatal intensive care units (NICUs). Patients 762 neonates admitted to six NICUs during a 28-month observational study for whom at ...
Hagmann C F - - 2011
BACKGROUND: Cranial ultrasound (cUS) findings help doctors in the clinical management of preterm infants and in their discussion with parents regarding prediction of outcome. cUS is often used as outcome measure in clinical research studies. Accurate cUS performance and interpretation is therefore required. AIMS: The aims of this study were ...
Dey S K - - 2011
SUMMARYSapovirus, a member of the family Caliciviridae, is one of the major causative agents of viral gastroenteritis affecting all age groups. A total of 3232 faecal specimens collected from infants and children with gastroenteritis in five different regions of Japan during 2003-2009 were examined for sapovirus by reverse transcription-polymerase chain ...
Shoji Hiromichi - - 2011
Conventional soybean lipid emulsions contain no docosahexaenoic acid (DHA) or arachidonic acid (AA). We investigated the relationship between blood DHA and AA status in 27 very-low-birth-weight (VLBW) infants with or without parenteral lipid emulsion. Sixteen infants received parenteral lipid emulsion, and 11 infants were control group. The fatty acid composition ...
O'Connor Alane - - 2011
Purpose: Within a family medicine residency, an outpatient buprenorphine treatment program was provided for pregnant women who were dependent on opioids. The purpose of this study was to investigate the outcomes of infants who were exposed to a range of doses of buprenorphine in utero and to determine how closely ...
Deng Li L Department of Vision Science, New England College of Optometry, Boston, Massachusetts 02115, USA. - - 2011
To investigate the association between birth month/photoperiod and refraction in infancy. Seven hundred twenty-two children with refractions measured between 1 and 3 months were included in this analysis. Non-cycloplegic near retinoscopy was performed by three experienced optometrists over a 32-year period. Photoperiod hours were calculated as the mean daylight hours ...
Morkane C - - 2011
Background/aims Treatment with intralesional triamcinolone/betamethasone is recommended for infantile sight-threatening periocular haemangiomas. This study investigates the endocrine and weight changes in 15 infants undergoing therapy over 12 years. Methods 15 infants, median age 19 weeks (range 10-56) receiving intra/perilesional triamcinolone/betamethasone underwent serial measurement of weight, early morning serum cortisol and ...
Prendergast M - - 2011
Please cite this paper as: Prendergast M, Rafferty G, Davenport M, Persico N, Jani J, Nicolaides K, Greenough A. Three-dimensional ultrasound fetal lung volumes and infant respiratory outcome: a prospective observational study. BJOG 2011; DOI: 10.1111/j.1471-0528.2010.02841.x. Objective  To determine if fetal lung volumes (FLVs), determined by three-dimensional rotational ultrasound and ...
Cogen Martin S - - 2011
To observe the effect of a topical anesthetic on pain and corneal clarity in premature infants undergoing eye examinations for retinopathy of prematurity (ROP). ROP examinations were performed on premature infants who were randomized to receive either proparacaine 0.5% or an artificial tear solution in the right eye. All infants ...
Cronin Katherine A - - 2011
The mother-offspring bond is one of the strongest and most essential social bonds. Following is a detailed behavioral report of a female chimpanzee 2 days after her 16-month-old infant died, on the first day that the mother is observed to create distance between her and the corpse. A series of ...
Senanayake M P - - 2011
A 4-month-old infant presented with continued fever, unresolving bronchopneumonia and household contact with sputum-smear-positive tuberculosis (TB) and showed marginal improvement on anti-TB chemotherapy. Recurrent pneumothorax prompted the clinical diagnosis of TB to be revised. High-resolution CT scan of the chest and open lung biopsy confirmed the diagnosis of pulmonary Langerhans ...
Asito Amolo S - - 2011
Plasmodium falciparum infection leads to alterations in B cell subset distribution. During infancy, development of peripheral B cell subsets is also occurring. However, it is unknown if infants living a malaria endemic region have alterations in B cell subsets that is independent of an age effect. To evaluate the impact ...
Granot Esther - - 2011
It is currently recommended that diet of pregnant mothers contain 200-300 mg DHA/day. Aim. To determine whether DHA supplementation during pregnancy and lactation affects infants' immune response. 60 women in ≥3rd pregnancy studied; 30 randomly assigned to receive DHA 400 mg/day from 12th week gestation until 4 months postpartum. From breast-fed infants, blood ...
Hutcheon Jennifer A - - 2011
Customized birth weight percentiles are weight-for-gestational-age percentiles that account for the influence of maternal characteristics on fetal growth. Although intuitively appealing, the incremental value they provide in the identification of intrauterine growth restriction (IUGR) over conventional birth weight percentiles is controversial. The objective of this study was to assess the ...
Woods Vanessa - - 2011
Bonobos have been observed to use socio-sexual behavior at higher frequency than chimpanzees. Little is known about the developmental influences that shape this behavior in bonobos. We compared the social sexual behavior of wild-born bonobo (n = 8) and chimpanzee (n = 16) infants in an experimental feeding test. Subjects of both species were ...
Dong Hong-Ying - - 2010
To observe the curative effect of TCM massage on difficulty in falling asleep, waking during night and other sleep disorder of infants. The 51 outpatients were treated by basic recipe for massage treatment and modified recipe according to syndromes. The total Athens Insomnia Scale (AIS) score 3.2800 +/- 1.5784 after ...
Yam Charmaine H - - 2011
The International Liaison Committee on Resuscitation recommends starting positive pressure ventilation (PPV) in the delivery room when heart rate (HR) <100 beats per min (bpm) and giving cardiac compressions when HR <60 bpm. Objective To describe the effect of PPV on HR in infants <30 weeks gestation with HR <100 ...
Poulton David A - - 2011
Current neonatal resuscitation guidelines recommend using visual assessment of chest wall movements to guide the choice of inflating pressure during positive pressure ventilation (PPV) in the delivery room. The accuracy of this assessment has not been tested. We compared the assessment of chest rise made by observers standing at the ...
Meijssen Dominique - - 2011
For very preterm infants the mother-infant relationship may be compromised. Maternal attachment representations 18 (corrected) months after very preterm birth and the effect of the post-discharge Infant Behavioral Assessment and Intervention Program (IBAIP) were studied. The IBAIP is designed to assist parents to support and enhance their infant's regulatory competence ...
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