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Nies Melanie M 1 Division of Pediatric Cardiology, Johns Hopkins Hospital, United States of - - 2013
Decades ago, mass-scale epidemiologic studies were undertaken to accurately describe the prevalence of congenital heart disease and associated malformations, and to identify inheritance patterns, teratogenic influence and aetiologic underpinnings. Despite phenomenal breakthroughs in molecular diagnosis of congenital heart disease, original population-based studies for detailed knowledge of prevalence, associated malformations, and ...
Molgat-Seon Y - - 2013
A fully functional radiant warmer induced rapid and continuous increases in regional skin temperatures, heart rate, mean arterial blood pressure and respiratory rate in a newborn patient without corrective action. We report this case of passive overheating to create awareness of the risks associated with regulating radiant heat output based ...
Fleck Brian W - - 2013
Emerging data from randomised controlled trials of different pulse oximeter oxygen saturation (SpO2) target ranges shows that higher SpO2 targets are associated with a higher risk of severe retinopathy of prematurity. However, the trials have also shown that higher SpO2 targets are associated with improved survival. In the light of ...
Candel-Pau Júlia - - 2012
Objective After the introduction of a new protocol based on the early treatment with indomethacin for patent ductus arteriosus, the objective of this study was to assess the safety and efficacy of this new practice in comparison with the safety and efficacy of the conventional treatment in a high-risk population.Study ...
Zhang X - - 2012
Please cite this paper as: Zhang X, Kramer M. The rise in singleton preterm births in the USA: the impact of labour induction. BJOG 2012; DOI: 10.1111/j.1471-0528.2012.03453.x. Objective  To assess the extent to which increased rates of labour induction and caesarean section have contributed to the recent rise in preterm ...
Yamada Takashi - - 2012
OBJECTIVES: To determine whether a low serum folate level during the first trimester predicts subsequent late abortion, preterm birth, or fetal growth restriction (FGR). STUDY DESIGN: A prospective cohort study involving 5,075 women whose serum folate levels were measured during the first trimester. The participants were informed of their serum ...
Stewart Robert D - - 2012
OBJECTIVE: We sought to determine if uterine tachysystole, ≥6 contractions per 10 minutes, within the first 4 hours of labor induction, is associated with adverse infant outcomes. STUDY DESIGN: This was a prospective cohort study of 584 women ≥37 weeks' gestation undergoing induction of labor with 100 μg of oral ...
Wickremasinghe Andrea C AC Department of Pediatrics, University of California San Francisco, San Francisco, CA 94143-0544, - - 2012
To examine whether a change in the approach to managing persistent patent ductus arteriosus (PDA) from early ligation to selective ligation is associated with an increased risk of abnormal neurodevelopmental outcomes. In 2005, we changed our PDA treatment protocol for infants born at ≤27 6/7 weeks' gestation from an early ...
Demirel Gamze - - 2012
Patent ductus arteriosus is a common problem in very low birth weight infants. Prostaglandin synthesis inhibitors such as indomethacin and ibuprofen are widely used preferred medications for ductal closure but the question of which one should be preferred is controversial. There are some studies in the literature comparing their pharmacokinetics, ...
Marsh Abigail A AA Department of Psychology, Georgetown University, 37th and O Streets NW, Washington, DC 20057, USA. - - 2012
Oxytocin is a neuropeptide that is associated with increases in social affiliative behaviors, particularly toward infants. However, no previous study has investigated healthy adults' responses to infant faces following oxytocin administration. In addition, given that preliminary evidence suggests that a single-nucleotide polymorphism of the oxytocin receptor (OXTR) gene, rs53576, may ...
Slager Joan - - 2012
Premature effacement of the cervix, or short cervix, in the midtrimester of pregnancy currently represents the strongest predictor of spontaneous preterm birth. Numerous studies have examined the relationship between short cervix and preterm birth, and although differences in sensitivity and predictive value exist, the overwhelming consensus indicates that the risk ...
Mirea Lucia - - 2012
OBJECTIVE: To examine the association between treatment for patent ductus arteriosus (PDA) and neonatal outcomes in preterm infants, after adjustment for treatment selection bias. STUDY DESIGN: Secondary analyses were conducted using data collected by the Canadian Neonatal Network for neonates born at a gestational age ≤32 weeks and admitted to ...
Natarajan Girija - - 2013
Permanent ductal closure involves anatomic remodeling, in which transforming growth factor (TGF)-β appears to play a role. Our objective was to evaluate the relationship, if any, between blood spot TGF-β on day 3 and day 7 of life and patent ductus arteriosus (PDA) in extremely low birth weight (ELBW) infants. ...
Lembo S - - 2012
A female infant had been delivered prematurely at 33 weeks to a gravida 1, para 0, 32-year-old mother following normal spontaneous vaginal delivery. Because of persistent patent ductus arteriosus the new born underwent surgery after 30 days. Four months later, when the infant arrived at our observation, approximately 13 red, ...
Petraglia Felice - - 2012
Endometriosis is a chronic inflammatory disease affecting women's health. Pain and infertility are the major symptoms caused by a hormonal/immunological dysfunction, which causes an endometrial impairment. The same pathogenetic mechanisms are also associated with preterm birth: hormones, cytokines, neurohormones, and growth factors interact in modulating extracellular matrix and prostaglandin secretion, ...
Feltovich Helen - - 2012
Spontaneous preterm birth is a heterogeneous phenotype. A multitude of pathophysiologic pathways culminate in the final common denominator of cervical softening, shortening, and dilation that leads to preterm birth. A precise description of specific microstructural changes to the cervix is imperative if we are to identify the causative upstream molecular ...
Mezu-Ndubuisi Olachi J - - 2012
Persistent patency of the ductus arteriosus is a major cause of morbidity and mortality in premature infants. In infants born prior to 28 weeks of gestation, a haemodynamically significant patent ductus arteriosus (PDA) can cause cardiovascular instability, exacerbate respiratory distress syndrome, prolong the need for assisted ventilation and increase the ...
Mercanti Isabelle - - 2012
The patency of the ductus arteriosus has ever been considered as a pathological situation in preterm infants and one likely cause of mortality and morbidity, including broncho-pulmonary dysplasia, necrotizing enterocolitis, intraventricular haemorrhage, retinopathy of prematurity. The incidence of patent ductus arteriosus is inversely proportional to gestational age and infants with ...
Schneider Douglas J - - 2012
During fetal life, the ductus arteriosus is a normal and essential structure that connects the pulmonary artery to the distal aortic arch, permitting right ventricular ejection into the aorta. After birth, with commencement of pulmonary blood flow and a 2-ventricle circulation, a variety of physiological and biochemical signals normally result ...
Bhatt Mayoor - - 2012
The effect of patent ductus arteriosus (PDA) treatment with cyclooxygenase (COX) inhibitors (indomethacin [INDO] and ibuprofen [IBU]) on regional oxygenation requires further clarification. The authors hypothesized that both INDO and IBU reduce regional tissue oxygenation in preterm neonates with PDA but that the risk is not uniform for different tissues ...
Coceani Flavio - - 2012
Closure of the ductus arteriosus at birth is a complex phenomenon being conditioned by antenatal events and progressing in preprogrammed steps. Functional at first, narrowing of the vessel is determined by 2 overlapping processes-removal of the prostaglandin E(2)-based relaxation sustaining prenatal patency and activation of a constrictor mechanism by the ...
Clyman Ronald I - - 2012
Although a moderate-sized patent ductus arteriosus (PDA) needs to be closed by the time a child is 1-2 years old, there is great uncertainty about whether it needs to be closed during the neonatal period. Although 95% of neonatologists believe that a moderate-sized PDA should be closed if it persists ...
Berman Jay M - - 2012
This case study describes the first reported vaginal delivery following radiofrequency ablation (RFA) of fibroids. The subject was among a cohort of women seeking treatment for symptomatic fibroids. She was enrolled in a clinical trial studying outcomes of laparoscopic, ultrasound-guided RFA of symptomatic fibroids. A 38-year-old, G4P3, female was diagnosed ...
Kim Joon Sik - - 2012
Patent ductus arteriosus (PDA) is a significant cause of morbidity and mortality in preterm infants. Measurement of plasma B-type natriuretic peptide (BNP) has been reported to be a useful bedside screening tool for the presence of hemodynamically significant PDA (hsPDA) in neonates. This study was conducted to investigate the usefulness ...
Vida Gabriella - - 2012
Background:  The study was undertaken to compare the effects of vaginal delivery and cesarean section on the l-arginine-NO system by measuring levels of l-arginine, an endogenous nitric oxide synthase antagonist asymmetric dimethylarginine (ADMA), and symmetric dimethylarginine (SDMA) levels in the cord blood and postnatally. Methods:  Plasma samples were obtained from ...
Mercanti Isabelle - - 2012
The patency of the ductus arteriosus has ever been considered as a pathological situation in preterm infants and one likely cause of mortality and morbidity, including broncho-pulmonary dysplasia, necrotizing enterocolitis, intraventricular haemorrhage, retinopathy of prematurity. The incidence of patent ductus arteriosus is inversely proportional to gestational age and infants with ...
Hanna Nazeeh - - 2012
Preterm labor and birth continue to pose a significant challenge to physicians in the obstetrics and neonatal fields. Until specific and effective therapeutic treatments are developed to prevent preterm labor, the best means of reducing preterm birth rate is early detection and diagnosis. However, current approaches to predict preterm labor ...
Giubilini Alberto - - 2012
Abortion is largely accepted even for reasons that do not have anything to do with the fetus' health. By showing that (1) both fetuses and newborns do not have the same moral status as actual persons, (2) the fact that both are potential persons is morally irrelevant and (3) adoption ...
Vidaeff Alex C - - 2012
We sought to determine if second-trimester amniotic fluid thrombin-antithrombin (TAT) complexes concentration correlates with subsequent preterm birth. A cohort of 550 women with singleton nonanomalous pregnancies undergoing second-trimester genetic amniocentesis was followed up to delivery and analyzed as a nested case-control study. Cases of preterm birth (n = 52) were ...
Shorten Allison - - 2012
Introduction: The recent National Institutes of Health consensus conference on vaginal birth after cesarean (VBAC) recommended a focus on strategies that increase women's opportunities to make informed choices about VBAC. This study aimed to expand knowledge of women's experiences of planned VBAC by focusing on postnatal experiences of women who ...
Strathearn Lane - - 2012
Oxytocin is a neuropeptide associated with social affiliation and maternal caregiving. However, its effects appear to be moderated by various contextual factors and stable individual characteristics. The purpose of this study was to investigate the relationship of self-reported state and trait measures (such as temperament, mood and affect) with peripheral ...
Scott-Joynt Michael - - 2012
The more vulnerable a person, of whatever age, therefore, the more there must be a presumption in favour of life; and care must be offered with particular respect and dignity, and in the best interests of the infant her/himself, not in those of others. The principles, that guide Christians in ...
Winrow Benjamin - - 2012
For a multitude of eminently modifiable reasons, death rates for pregnant women and girls and their newborn infants in poorly resourced countries remain unacceptably high. The concomitant high morbidity rates compound the situation. The rights of these vulnerable individuals are incompletely protected by existing United Nations human rights conventions, which ...
Stein Werner - - 2012
Abstract Objective: To analyze the relationship of the time interval between two deliveries, done by one obstetric team, on the delivery mode of the subsequent birth; to define the length of this interval; and to evaluate this time interval as a risk factor for increased perinatal mortality in a population-based ...
Akinsipe D Claudia - - 2012
To evaluate the effect of implementing hospital policies aimed at reducing elective labor induction and increasing spontaneous labor rates. PubMed, CINAHL, Cochrane Database of Systematic Reviews, and Dissertation Abstracts International. Observational studies published from 2000 to 2010 were the only original studies from the past 20 years that met the ...
Jefferson Kimberly K - - 2012
Preterm birth is the leading cause of infant morbidity and mortality. Very preterm births, those occurring before 32 completed weeks of gestation, are associated with the greatest risks. The leading cause of very preterm birth is intrauterine infection, which can lead to an inflammatory response that triggers labor or preterm ...
Tarannum Fouzia - - 2012
Background: Periodontal infections, which serve as a reservoir of inflammatory mediators such prostaglandin E 2 (PGE 2 ), may pose a threat to the fetal-placental unit and cause preterm delivery. Aim: This study was conducted to estimate the PGE 2 levels in gingival crevicular fluid (GCF) and to explore the ...
Oladapo Olufemi T - - 2012
There is a general agreement that oxytocin given either through the intramuscular or intravenous route is effective in reducing postpartum blood loss. However, it is unclear whether the subtle differences between the mode of action of these routes have any effect on maternal and infant outcomes. To determine the comparative ...
Spatz Diane L - - 2011
Infant admission to the Neonatal Intensive Care Unit requires that the family receives the scientific rationale for the importance of providing human milk for their child. The initiation and maintenance of maternal milk supply must be a priority. Understanding variation in milk composition is crucial so that the infant receives ...
Dahmardeh Behrooz Reza - - 2011
Human milk is usually the only source of food for infants during the first 4 to 5 months of their life. In this research, 80 human milk samples were collected from mothers in Tehran, Noushahr and the countryside of Tabriz, Iran, who were not occupationally exposed to mercury. The mean concentration ...
Jantscher-Krenn Evelyn E University of California-San Diego, Department of Pediatrics, Division of Neonatal Medicine, 200 West Arbor Drive, MC 8450, San Diego, CA 92103-8450, - - 2012
Necrotising enterocolitis (NEC) is one of the most common and fatal intestinal disorders in preterm infants. Breast-fed infants are at lower risk for NEC than formula-fed infants, but the protective components in human milk have not been identified. In contrast to formula, human milk contains high amounts of complex glycans. ...
Takahashi Kenichiro - - 2011
Although mother's milk is the optimal nutrition for preterm infants, the amount of protein, calcium, and phosphorus become inadequate for the growth of preterm infants, such that fortification is recommended when enteral feeding is established. Recently, intestinal obstruction due to calcium soap formation has been reported. All the reported cases ...
Maayan-Metzger Ayala - - 2011
We evaluated short-term neonatal outcomes among preterm infants according to type of feeding administered (human milk or formula). Retrospective data were collected on 400 preterm infants at gestational age ≤32 weeks. Groups were chosen and compared according to feeding type. The premature infants who were fed human milk had lower ...
Devanathan Gnanasekaran - - 2012
This study investigated the status of contamination of organohalogen compounds (OCs) such as polychlorinated biphenyls (PCBs) and brominated flame retardant (BFRs), including polybrominated diphenyl ethers (PBDEs) and hexabromocyclododecanes (HBCDs) in human milk samples from several locations in India. The levels of OCs were significantly higher in the milk of mothers ...
Kraebel Kimberly S - - 2012
The current study examined the role redundant amodal properties play in an operant learning task in 3-month-old human infants. Prior studies have suggested that the presence of redundant amodal information facilitates detection and discrimination of amodal properties and potentially functions to influence general learning processes such as associative conditioning. The ...
Almeida Mariangela Bartha de Mattos de MB Fernandes Figueira Institute, Oswaldo Cruz Foundation, Rio de Janeiro, RJ, Brazil. - - 2011
Neonatal nutrition is an important subject in health in the short, medium and long term. In preterm newborns, nutrition assumes a predominant role for the child's overall development. Babies with uncoordinated swallowing or respiration may not have the necessary oral abilities to suck the mother's breast and will need to ...
Hsu Ho-Torng - - 2011
Abstract Background and Aims: Human milk bank is a source of human milk supply in many neonatal intensive care units. However, there are some hospitals without this facility because of financial or religious impediments, such as the Muslim community. Methods: We introduced human milk donation as an alternative to human ...
Lizza John P - - 2011
The 'decapitation gambit' holds that, if physical decapitation normally entails the death of the human being, then physiological decapitation, evident in cases of total brain failure, entails the death of the human being. This argument has been challenged by Franklin Miller and Robert Truog, who argue that physical decapitation does ...
Philipp M T - - 2012
Nasopharyngeal colonization by Streptococcus pneumoniae precedes pneumococcal disease. Elucidation of procedures to prevent or eradicate nasopharyngeal carriage in a model akin to the human would help to diminish the incidence of both pneumonia and invasive pneumococcal disease. We conducted a survey of the nasopharynx of infant rhesus macaques from our ...
Brenner Michelle G - - 2011
Abstract Hospital breastfeeding initiation rates (75%) show that most mothers in the United States want to breastfeed and are trying to do so. Even from the very start, however, mothers may not be getting the breastfeeding support they need. Low breastfeeding rates at 3, 6, and 12 months illustrate that ...
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