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Enomoto Tadao T NPO (Nonprofit Organization) Japan Health Promotion Supporting Network, Wakayama, - - 2014
Background: Probiotic administration may be a useful method for preventing allergies in infants; however, there have been controversial results about the efficacy. We investigated the effects of bifidobacterial supplementation on the risk of developing allergic diseases in the Japanese population. Methods: In an open trial, we gave Bifidobacterium breve M-16V ...
Moya-Alvarez Violeta - - 2014
Albeit pregnancy-associated malaria (PAM) poses a potential risk for over 125 million women each year, an accurate review assessing the impact on malaria in infants has yet to be conducted. In addition to an effect on low birth weight (LBW) and prematurity, PAM determines foetal exposure to Plasmodium falciparum in ...
McCarty-Singleton Siobhan S Christiana Care Hospital, Newark, - - 2014
Activity restriction is one of the most common practices used for the prevention of preterm birth. Despite the lack of evidence to support the efficacy of activity restriction, and newer data that highlight potential harms to the mother, the intervention is still prescribed. This review of the literature describes the ...
Olusanya Bo B Centre for Healthy Start Initiative, 286A Corporation Drive, Dolphin Estate, Ikoyi, P.O.Box 75130 VI, Lagos, - - 2014
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an established worldwide risk factor for severe hyperbilirubinaemia. This literature review examined the pattern and management of severe hyperbilirubinaemia in low and middle-income countries (LMICs) where G6PD deficiency was 10% or more and found that it was frequently associated with neonatal mortality and, or, neurodevelopmental disorders. ...
Yang Mei M Department of Maternal and Child Health, Tongji Medical College, Huazhong University of Science and Technology , Wuhan , China - - 2014
Abstract Objectives: To explore the epidemiology characteristics of birth defects (BDs) in perinatal infants in Longgang District, Shenzhen City. Methods: Data used in this study was obtained from birth defects surveillance network during 2003 to 2009. The prevalence with 95% confidence interval of BDs by year, gender, household registration and ...
Graham Simon M SM *Countess of Chester Hospital, The Countess of Chester Health Park, Chester, Cheshire, UK †Beit Cure International Hospital, Blantyre, - - 2014
Developmental dysplasia of the hip (DDH) is rarely encountered in the native sub-Saharan African population. We present a retrospective review of the incidence of symptomatic DDH in Malawi and a systematic review of the role of back-carrying as a potential influence of prevalence in this population group. We retrospectively reviewed ...
Eckhardt Cara L - - 2014
The promotion of healthy infant feeding is increasingly recognized as an important obesity-prevention strategy. This is relevant for American Indian populations that exhibit high levels of obesity and low compliance with infant feeding guidelines. The literature examining the knowledge, attitudes, and beliefs surrounding infant feeding within the American Indian population ...
Wetta Luisa A LA Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, University of Alabama at Birmingham, Birmingham, - - 2014
Preterm birth remains a considerable public health concern and priority. Little headway has been made in the prevention of preterm birth despite considerable research in this area. New ideas and treatments are desperately needed. The pessary has emerged as a possible treatment for the prevention of preterm birth in both ...
Niu Brenda B Obstetrics and Gynecology, Oregon Health & Science University, Portland, OR. Electronic address: - - 2014
Gestational diabetes type A1 (A1GDM), also known as diet-controlled gestational diabetes, is associated with an increase in adverse perinatal outcomes such as macrosomia and Erb's palsy. However, it remains unclear when to deliver these women because optimal timing of delivery requires balancing neonatal morbidities from early term delivery against the ...
Good Misty M Department of Pediatrics, Division of Newborn Medicine, Children's Hospital of Pittsburgh, Pittsburgh, PA, - - 2014
Necrotizing enterocolitis (NEC) is a devastating disease of premature infants and is associated with significant morbidity and mortality. While the pathogenesis of NEC remains incompletely understood, it is well established that the risk of disease is increased by the administration of infant formula and decreased by the administration of breast ...
Koh K K Department of Hematology/Oncology, Saitama Children's Medical Center, Saitama, - - 2014
Sixty-two infants with MLL gene-rearrangement-positive acute lymphoblastic leukemia (MLL-r ALL) were treated with the MLL03 protocol of the Japanese Pediatric Leukemia/Lymphoma Study Group: short-course intensive chemotherapy followed by early allogeneic hematopoietic stem cell transplantation (HSCT) within 4 months of the initial induction. The 4-year event-free survival (EFS) and overall survival ...
Avraham Sarit S Department of Obstetrics and Gynecology, Liss Maternitry Hospital, Tel-Aviv Medical Center, Tel-Aviv, Israel ; The Sackler School of Medicine, Tel-Aviv University, Tel-Aviv Medical Center, Tel-Aviv, - - 2014
Preterm birth is a global concern resulting in prematurity which is the leading cause of newborn death and long-term squeal in the survivors. In this review, we will summarize the data available to this date in regard to the causes, available interventions, and contemporary research for future applications.
Balain M M Embrace Transport Service, Sheffield Children's Hospital NHS Trust, Barnsley, - - 2014
Probiotics have been shown to reduce the risk for definite Necrotising enterocolitis (NEC) and all-cause mortality in very low birth weight babies without any significant adverse effects in > 5000 babies 1-3. Some neonatal units administer probiotics routinely to babies less than 1500g or 32 weeks gestation. PINC UK (Probiotics ...
Vandenplas Yvan Y Department of Pediatrics, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, - - 2014
Presented are guidelines for the prevention, diagnosis, and treatment of cow's milk protein allergy (CMPA) which is the most common food allergy in infants. It manifests through a variety of symptoms that place a burden on both the infant and their caregivers. The guidelines were formulated by evaluation of existing ...
Allegaert Karel K Neonatal Intensive Care Unit, University Hospitals Leuven, Leuven, Belgium; Department of Development and Regeneration, KU Leuven, - - 2014
Drug therapy is a powerful tool to improve outcome, but there is an urgent need to improve pharmacotherapy in neonates through tailored adverse drug reaction (ADR) prevention and management. At present, infants commonly receive off label drugs, using doses extrapolated from those in children or adults. Besides the lack of ...
Kubo Ai - - 2014
For mothers with chronic hepatitis B virus (HBV) infection, the Centers for Disease Control and Prevention recommends immunoprophylaxis to decrease perinatal transmission. However, its effectiveness and risk factors for failure have not been well-studied in community practice. To investigate the effectiveness of a contemporary immunoprophylaxis protocol. Observational study. An HBV ...
Papanna Ramesha R Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology and Reproductive Sciences, UT Health School of Medicine, Houston, - - 2014
Preterm birth after fetoscopic laser surgery for twin-twin transfusion continues to be a major challenge despite improved survival rates. The risk factors for the complications have been identified, which include preterm premature rupture of membranes, cervical length shortening, larger cannula diameter, amnioinfusion, complicated procedure, and severe disease. The interventions to ...
Jones Cheryl A CA Discipline of Paediatrics and Child Health , Sydney Medical School and the Marie Bashir Institute for Infectious Diseases and Biosecurity, , The University of Sydney and the Department of Microbiology and Infectious Diseases, The Children's Hospital at - - 2014
 Neonatal herpes simplex virus (HSV) infection is uncommon, but mortality after disseminated disease and morbidity after encephalitis is high. For the last decade, increased dose and duration of acyclovir has been advised to prevent disease progression and recurrence. We sought to determine prospectively the epidemiologic, clinical and secular trends of ...
Urbańska Magdalena M Department of Paediatrics, The Medical University of Warsaw, 01184, Warsaw, Działdowska 1, Poland, - - 2014
We aimed to systematically evaluate evidence on the effectiveness of Lactobacillus reuteri DSM 17938 (L. reuteri) for treating and preventing diseases in infants and children. MEDLINE and the Cochrane Library were searched in December 2013, with no language restrictions, for relevant randomized controlled trials (RCTs) and meta-analyses. The search was ...
Iams Jay D JD Ohio State University Wexner Medical Center, Columbus, - - 2014
Recognition of preterm birth as the major underlying cause of infant mortality in the United States has placed responsibility for prevention in the hands of obstetrician-gynecologists. The advent of effective methods to identify and treat women with increased risk is a major advance that will alter the focus of prenatal ...
O'Keeffe Gerard W GW Irish Centre for Fetal and Neonatal Translational Research (INFANT), Cork University Maternity Hospital, Cork, Ireland; Department of Anatomy and Neuroscience, Biosciences Institute, University College Cork, Cork, Ireland. Electronic address: - - 2014
Identifying those infants most at risk for poor neurodevelopmental outcomes is crucial to allow for targeted surveillance or preventative interventions to be instigated from birth. One intriguing possibility is to use the molecular characteristics of the placenta at birth as a 'molecular barometer' of the in utero experience to predict ...
Fanni Daniela D Department of Pathology, University Hospital San Giovanni di Dio, AOU Cagliari and University of Cagliari, Cagliari, - - 2014
During the last years, human newborns have been overexposed to biologically reactive aluminum, with possible relevant consequences on their future health and on their susceptibility to a variety of diseases. Children, newborns and particularly preterm neonates are at an increased risk of aluminum toxicity because of their relative immaturity. Based ...
Torres Victorio V a Vihda Association , Nairobi , - - 2014
Although the attainment of Millennium Development Goal 4 (MDG 4), reducing under-five mortality by two-thirds by the year 2015, depends on optimizing breast-feeding practices in resource-limited settings, there are some conditions in which breast-feeding is impossible, contraindicated, or not recommended. The overall impact of involuntary nonbreast-feeding on the attainment of ...
Baker Christopher D CD aSection of Pulmonary Medicine and Pediatric Heart Lung Center, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA bDepartment of Pediatrics, Center for Excellence in Pulmonary Biology, Stanford University School of Medicine, Stanford, California, - - 2014
Advances in medical therapy have increased survival of extremely premature infants and changed the pathology of bronchopulmonary dysplasia (BPD) from one of acute lung injury to a disease of disrupted lung development. With this evolution, new questions emerge regarding the molecular mechanisms that control postnatal lung development, the effect of ...
Murki Srinivas S Department of Pediatrics, Fernandez Hospital, Hyderabad, - - 2014
Respiratory distress syndrome (RDS) is a major disease burden in the developing countries. Current evidence supports early continuous positive airway pressure (CPAP) use and early selective surfactant administration as the most efficacious interventions in the management of RDS, both in developed and developing countries. In developing countries, it is recommended ...
Alfaleh Khalid K Department of Pediatrics (Division of Neonatology), King Saud University, King Khalid University Hospital and College of Medicine, Department of Pediatrics (39), P.O. Box 2925, Riyadh, Saudi Arabia, - - 2014
Necrotizing enterocolitis (NEC) and nosocomial sepsis are associated with increased morbidity and mortality in preterm infants. Through prevention of bacterial migration across the mucosa, competitive exclusion of pathogenic bacteria, and enhancing the immune responses of the host, prophylactic enteral probiotics (live microbial supplements) may play a role in reducing NEC ...
Illanes Sebastián E SE Universidad de Los Andes, Department of Obstetrics & Gynaecology and Laboratory of Reproductive Biology, Faculty of Medicine , Santiago , - - 2014
Introduction: In developed countries, preterm birth is the major cause of perinatal morbidity, mortality and the most important public health problem in the obstetric field. In the past decades, an increasing trend has been observed regardless of the great efforts focussed on the improvement of our understanding of the physiopathological ...
van Teeffelen Augustinus S - - 2014
Babies born after midtrimester preterm prelabour rupture of membranes (PPROM) are at risk to develop neonatal pulmonary hypoplasia. Perinatal mortality and morbidity after this complication is high. Oligohydramnios in the midtrimester following PPROM is considered to cause a delay in lung development. Repeated transabdominal amnioinfusion with the objective to alleviate ...
Levison Judy - - 2014
The overarching goal of this study was to qualitatively assess baseline knowledge and perceptions regarding preterm birth (PTB) and oral health in an at-risk, low resource setting surrounding Lilongwe, Malawi. The aims were to determine what is understood regarding normal length of gestation and how gestational age is estimated, to ...
McEvoy Cindy T CT 1 Department of Pediatrics, Oregon Health and Science University, Portland, - - 2014
Bronchopulmonary dysplasia (BPD) is the most common complication of extreme preterm birth. Infants who develop BPD manifest aberrant or arrested pulmonary development and can experience lifelong alterations in cardiopulmonary function. Despite decades of promising research, primary prevention of BPD has proven elusive. This workshop report identifies current barriers to the ...
Kasivajjula Himabindu H Division of Neonatology and the Center for Neonatal and Pediatric Gastrointestinal Disease, Department of Pediatrics, University of Illinois at Chicago, Chicago, IL, - - 2014
Necrotizing enterocolitis (NEC), an inflammatory bowel necrosis of preterm infants, is the most common gastrointestinal emergency and a major cause of morbidity and mortality in these infants. In this article, the authors review the pathophysiology and clinical presentation of NEC and provide a critical appraisal of the evidence supporting various ...
Vandenplas Y Y UZ Brussel, Vrije Universiteit Brussel, Brussels, - - 2014
Experts reviewed the literature to determine if partial whey hydrolysed formulas (HF) offers benefits in the dietary management of frequent gastro-intestinal symptoms and allergy prevention. Compared to standard cow's milk-based formulas, partial whey HF confers a limited protective effect against allergic disease in high-risk infants, particularly atopic dermatitis, but not ...
Carl Mike A MA Department of Pediatrics, Washington University School of Medicine, St Louis, - - 2014
Background. Late-onset sepsis is a major problem in neonatology, but the habitat of the pathogens before bloodstream invasion occurs is not well established. Methods. We examined prospectively collected stools from premature infants with sepsis to find pathogens that subsequently invaded their bloodstreams, and sought the same organisms in stools of infants without ...
Ditekemena John J Elizabeth Glaser Paediatric AIDS Foundation, Kinshasa, Democratic Republic of - - 2014
Effective follow-up of mother-infant pairs is critical for ensuring the success of preventing mother-to-child transmission (PMTCT) programs. The objective of this study was to identify factors associated with health outcomes of exposed infants in a PMTCT program in the Democratic Republic of Congo (DRC). Data were collected from January 2005 ...
Clark Steven L SL From the Hospital Corporation of America, Nashville, Tennessee. Electronic address: - - 2014
To examine the efficacy of specific protocols developed in response to a previous analysis of maternal deaths in a large hospital system. We also analyzed the theoretical impact of an ideal system of maternal triage and transport on maternal deaths and the relative performance of cause of death determination from ...
Micek Mark A MA University of Washington, Seattle, Washington, - - 2014
Acquisition of nevirapine (NVP)-resistant-HIV-1 by breastfeeding infants, following single-dose-NVP to prevent mother-to-child-transmission, is not well defined. A prospective observational study of 307 infants evaluated the rate of breast milk transmission of NVP-resistant-HIV-1, and the concentrations of mutants over time. NVP-resistance was detected in 9/24 breast milk-infected infants (37.5%, 95% CI ...
Panigrahi Pinaki P Department of Epidemiology and Pediatrics, University of Nebraska Medical Center, Omaha, NE, United States; Center for Global Health and Development, College of Public Health, Omaha, NE, United States. Electronic address: - - 2014
Neonatal necrotizing enterocolitis (NEC) in premature infants has been recognized as a defined disease entity for at least four decades. Although survival has increased due to the advent of more sophisticated intensive care, incidence and long term health impacts due to NEC remain unchanged and no preventive therapy is currently ...
Griffin Russell L RL Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama, - - 2014
The distribution of time from acute traumatic injury to death has three peaks: immediate (less than or equal to one hour), early (6 to 24 hours), and late (days to weeks). It has been suggested that coordinated trauma care dampens the late peak; however, this research may be more reflective ...
Horne Rosemary Sc RS The Ritchie Centre, Monash Institute of Medical Research, Monash University, Melbourne, - - 2014
The large decline in deaths due to the sudden infant death syndrome (SIDS) in the last 20 years in many countries is largely due to risk-reduction advice resulting from observational studies that examined the relationship between infant care practices and SIDS. Most of this advice remains largely uncontroversial and educators ...
Tzialla Chryssoula C Neonatal Intensive Care Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy. Electronic address: - - 2014
The incidence of neonatal early-onset group B streptococcus (GBS EOS) sepsis has declined during the last decade since the implementation of intrapartum antibiotic prophylaxis endorsed by Centers for Disease Control and Prevention (CDC) guidelines. All the CDC guidelines versions provide recommendations for neonatal management. The neonatal algorithm of CDC has ...
Dessì Angelica A Neonatal Intensive Care Unit, Puericulture Institute and Neonatal Section, Azienda Ospedaliera Universitaria, University of Cagliari, Cagliari, - - 2014
Systemic neonatal infection is a serious complication in preterm and term infants and is defined as a complex clinical syndrome caused by bacteria, fungi and virus. Sepsis remains among the leading causes of death in both developed and underdeveloped countries above all in the neonatal period. Earlier diagnosis may offer ...
Forae Gerald Dafe GD Department of Pathology, University of Benin Teaching Hospital, Benin City, - - 2014
The 4(th) millennium development goals (2002) reported that sub-Saharan Africa countries including Nigeria have a persistently high childhood mortality rates in-spite of all the preventive and interventional measures to reduce this ugly trend. Childhood mortality data was obtained from the medical records department and post-mortem records of the pathology departments ...
Schulte Rachael R Division of General Pediatrics, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, - - 2014
Newborns are at risk for vitamin K deficiency and subsequent bleeding unless supplemented at birth. Vitamin K deficiency bleeding is an acquired coagulopathy in newborn infants because of accumulation of inactive vitamin K-dependent coagulation factors, which leads to an increased bleeding tendency. Supplementation of vitamin K at birth has been ...
Barrett Helen L HL Internal Medicine, Royal Brisbane and Women's Hospital, Butterfield Street, Herston, Queensland, Australia, - - 2014
Gestational diabetes mellitus (GDM) is associated with a range of adverse pregnancy outcomes for mother and infant. The prevention of GDM using lifestyle interventions has proven difficult. The gut microbiome (the composite of bacteria present in the intestines) influences host inflammatory pathways, glucose and lipid metabolism and, in other settings, ...
Jain Deepak D University of Miami, Miami, - - 2014
Since Northway's original description of BPD almost 45 years ago, the clinical presentation of BPD has evolved into a disease process, which mostly involves extremely premature infants. This new form of BPD is the result of multiple antenatal and postnatal factors that can cause injury to the developing lung leading ...
Biran Valérie V Neonatal Intensive Care Unit, Hôpital Robert Debré, Assistance Publique-Hôpitaux de Paris, Université Paris Diderot, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, INSERM, Paris, France; PremUP Foundation, Paris, - - 2014
The prevention of neurological disabilities following preterm birth remains a major public health challenge and efforts are still needed to test the neuroprotective properties of candidate molecules. Melatonin serves as a neuroprotectant in adult models of cerebral ischemia through its potent antioxidant and anti-inflammatory effects. An increasing number of preclinical ...
Uberos J J Unidad Neonatal, Servicio de Pediatría, Hospital Clínico San Cecilio, Avenida del Doctor Oloriz, 16, 18012 Granada, Spain. Electronic address: - - 2014
To assess the effectiveness of vitamin A supplementation in very low birth weight (VLBW) infants to prevent complications of prematurity. A retrospective cohort study to determine the effectiveness of vitamin A in preventing complications of prematurity in VLBW infants. Vitamin A was delivered intramuscularly at a dose of 5000 IU, three ...
van Vliet Elvira Og EO UMC Utrecht, Department of Obstetrics and Gynaecology , WKZ, PO Box 85090, 3508 AB Utrecht , Netherlands - - 2014
Introduction: In the developed world, preterm birth is in quantity and in severity the most important issue in obstetric care. Adverse neonatal outcome is strongly related to gestational age at delivery. Since the pathophysiological mechanism of preterm birth is not yet completely unraveled, the development of successful preventive strategies is ...
Joseph Christine L M CL Department of Public Health Sciences, Henry Ford Hospital, Detroit, MI, USA; Center for Allergy, Asthma and Immunology Research, Henry Ford Hospital, Detroit, MI, - - 2014
The infant gut's ability to suppress immunologic reactions to food proteins could be influenced by levels of TGFβ in breast milk. We hypothesized that lower levels of TGFβ1 in the breast milk (BM) of mothers in the WHEALS birth cohort are associated with atopy at infant age 2-3 yrs. We used ...
Mitchell Caroline C University of Washington, Seattle, - - 2014
Among HIV-1-exposed infants, detection of viral infection at birth was increased by 39% (95% CI 19-47%) by increasing DNA input from dried blood spots into PCR. Infants with low concentrations of HIV-1 at birth may be the best target population to evaluate whether immediate antiretroviral therapy can prevent long-term infection.
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