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Celine Tm - - 2013
Childhood mortality is increasing day by day. It will affect the development of the nation. Preventive measures on childhood mortality could be an effective approach for saving child's life. To find out the causes of deaths among children below 12 years of age those who were admitted in a teaching ...
Cakır Ufuk - - 2013
Maternal primary hyperparathyroidism causing hypercalcemia during pregnancy can suppress fetal and neonatal parathyroid hormone secretion. We report a newborn with transient hypoparathyroidism presented by hypocalcemic seizure and tetany on the 21st postnatal day in whom the final diagnosis was asymptomatic maternal primary hyperparathyroidism. Neonatal hypocalcemia usually occurs early in life ...
Sachdeva Sandeep S Department of Community Medicine, Pt. B.D. Sharma, PGIMS, Rohtak, Haryana, - - 2013
Registration of birth is mandatory in India however due to various issues compliance for timely birth registration has been poor. The objective of this study was to determine time elapsed between birth and registration and describe the socio-demographic profile of registered births at a rural center. A cross-sectional descriptive study ...
Linder Nehama N Department of Neonatology, Rabin Medical Center, Beilinson Campus, Petach Tikva, Israel. - - 2013
Vancomycin is widely used to treat late onset coagulase-negative Staphylococcus (CoNS) sepsis in very low birth weight (VLBW) infants. Although vancomycin is associated with a risk of toxicity and bacterial resistance, the appropriate duration of use has not been established. This study sought to investigate the association between the duration ...
Hornik Christoph P CP Duke Clinical Research Institute and Department of Pediatrics, Duke University, Durham, NC 27715, - - 2013
Carbapenems are commonly used in hospitalized infants despite a lack of complete safety data and associations with seizures in older children. We compared the incidence of adverse events in hospitalized infants receiving meropenem versus imipenem/cilastatin. We conducted a retrospective cohort study of 5566 infants treated with meropenem or imipenem/cilastatin in ...
Macnow Theodore - - 2013
Infections with antibiotic resistant organisms (AROs) are an important source of morbidity and mortality among infants hospitalized in the neonatal intensive care unit (NICU). To identify potential reservoirs of AROs in the NICU, active surveillance strategies have been adopted by many NICUs to detect infants colonized with AROs. However, the ...
König Kai - - 2013
Abstract Objective: Sildenafil has been shown to preserve alveolar growth and lung angiogenesis in a rat model of bronchopulmonary dysplasia. We conducted a proof-of-concept randomised controlled pilot study to assess the feasibility of oral sildenafil treatment in extremely preterm infants with evolving bronchopulmonary dysplasia. Methods: Preterm infants <28 weeks gestational ...
Bos Marthel E - - 2013
A Lactobezoar is a compact mass of inspissated, indigested milk. Most often it is located in the stomach but it also may be located in other parts of the intestine. It is the most common type of bezoar in infancy. We report two cases of this rare condition mimicking necrotizing ...
Wessel David L - - 2013
Background Infants with cyanotic congenital heart disease palliated with placement of a systemic-to-pulmonary-artery shunt are at risk for shunt thrombosis and death. We investigated whether the addition of clopidogrel to conventional therapy reduces mortality from any cause and morbidity related to the shunt. Methods In a multicenter, double-blind, event-driven trial, ...
Arnon Shmuel - - 2013
To examine the effect of initiating very early feeding on time-to-reach full feeding in stable, small for gestational age (SGA) preterm infants. Preterm infants with gestational age below 37 weeks and birth weight below the 10(th) percentile were randomly allocated to a very early (within 24hours of birth) feeding regimen ...
Maede Yoshinobu - - 2013
OBJECTIVE: We conducted a comparative clinical study to evaluate the prophylactic effects of micafungin (MCFG) and fluconazole (FLCZ) on the incidence of fungal infections in extremely low birth weight (ELBW) infants who were born at a gestational age of less than 26 weeks and weighed less than 1,000 g. STUDY ...
Bene Judit - - 2013
OBJECTIVES:: The aim of the study was to compare plasma carnitine profiles in preterm infants fortified human milk-fed or preterm infant formula-fed. METHODS:: Plasma acylcarnitine concentrations were determined in 20 formula-fed and 18 human milk-fed preterm infants (birth-weights between 1000 and 2200 g) by isotope dilution ESI MS/MS technique on ...
Marsot Amélie - - 2013
Phenobarbital is widely used for treatment of neonatal seizures. Its optimal use in neonates and young infants requires information regarding pharmacokinetics. The objective of this study is to characterize the absolute bioavailability of phenobarbital in neonates and young infants, a pharmacokinetic parameter which has not yet been investigated. Routine clinical ...
Shellhaas Renée A RA Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, USA. - - 2013
We evaluated the utility of amplitude-integrated EEG (aEEG) and regional oxygen saturation (rSO2) measured using near-infrared spectroscopy (NIRS) for short-term outcome prediction in neonates with hypoxic ischemic encephalopathy (HIE) treated with therapeutic hypothermia. Neonates with HIE were monitored with dual-channel aEEG, bilateral cerebral NIRS, and systemic NIRS throughout cooling and ...
Fukazawa Mitsuharu - - 2013
Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening syndrome characterized by fever, cytopenias, hepatosplenomegaly, and coagulopathy with the background of hypercytokinemia. Early diagnosis and etoposide therapy are not established for affected newborns. An afebrile infant suffered from apnea 4 days after birth, showing leukocytosis, thrombocytopenia, coagulopathy, and cerebrospinal fluid pleocytosis. Serum levels ...
Filippidi Anthoula - - 2013
Colonisation may be the first step for the development of Candida infection. The source of neonatal colonisation is thought to be the hospital environment or the maternal vaginal tract. This study investigated to what extend Candida isolates in neonates are similar to isolates from their mother's vaginal tract. Vaginal samples ...
Lagatta Joanne M JM Medical College of Wisconsin, Milwaukee, WI. Electronic address: - - 2013
To compare proportions of infants at different gestational ages discharged from the neonatal intensive care unit (NICU) on home oxygen, to determine how many were classified with chronic lung disease based on timing of discharge on home oxygen, and to determine the percentage discharged on home oxygen who received mechanical ...
van der Sluis Inge - - 2013
The pharmacokinetics, pharmacodynamics, efficacy and safety of a new recombinant E.coli-asparaginase preparation was evaluated in infants (< 1 year of age) with de novo acute lymphoblastic leukemia. Twelve patients were treated according to the INTERFANT-06 protocol and received up to 10,000 U/m2; recombinant asparaginase as intravenous infusion on days 15, ...
Shima Yoshio - - 2013
BACKGROUND: The aim of the study was to determine factors that affect adverse long-term pulmonary outcomes of premature infants. METHODS: The retrospective analysis was made on 306 clinical records of preterm singleton neonates at <32 weeks of gestation. Two definitions of adverse pulmonary outcomes were used in this study: Chronic ...
Patel Pankaj - - 2013
AIM: To determine the short-term outcomes of Australian buprenorphine-exposed mother/infant dyads. METHODS: Retrospective record review of drug-exposed mothers and infants in Australia. Groups were based on drug exposure: buprenorphine (55, 3.8%), non-buprenorphine opiates (O, 686, 48.6%) and non-opiates (NO, 671, 47.5%). RESULTS: More than 30% of buprenorphine mothers continued to ...
Karthikeyan Ambika - - 2013
Abstract Aim: Cranial diabetes insipidus (CDI) is rare in infants with no guidelines on its management. We describe the first case series, characterizing the clinical features and treatment challenges. Method: Retrospective case note review of infants diagnosed with CDI between April 1992 and February 2011. Results: Nineteen infants (52% male) ...
Sheikh Sukhera - - 2013
Operative vaginal delivery has been described since the Middle Ages. During this time, however, labour would be sustained over several days and intrapartum death almost inevitable. In these circumstances, intervention involving the use of surgical instruments or even kitchen utensils would serve purely as an attempt to avoid maternal mortality. ...
Malik Akash - - 2013
BACKGROUND:Zinc supplementation during diarrhea substantially reduces the incidence and severity of diarrhea. However, the effect of short-course zinc prophylaxis has been observed only in children >12 months of age. Because the incidence of diarrhea is comparatively high in children aged 6 to 11 months, we assessed the prophylactic effect of ...
Kaga Akimune - - 2013
Skin hamartoma is an extremely rare disease on the hand in newborn infants. Reported herein is the case of a newborn infant who presented with a skin hamartoma on the hand. The patient was a girl born at 37 weeks of gestational age. The mass was seen on her proximal ...
van Beusekom Ilse - - 2013
The World Health Organization (WHO) recommends exclusive breastfeeding, defined as receiving only breastmilk, through the first 6 months of life to optimize survival, health, and development. To assess exclusive and predominant breastfeeding rates, as defined by WHO, in a sample of Guatemalan infants using three dietary assessment methods. Mothers of ...
Bassil Kate L - - 2013
Objective To examine the short-term morbidities, mortality, and use of neonatal intensive care unit (NICU) resources for late preterm, early term, and term infants.Study Design Infants born between 34 and 40 weeks of gestation and admitted to a Canadian NICU in 2010 were designated late preterm (340/7 to 366/7 weeks), ...
Watts Stewart - - 2013
Adequate phosphate intake is important for the prevention of metabolic bone disease in preterm infants. The European Society for Paediatric Gastroenterology, Hepatology and Nutrition recommends a daily phosphate intake of 184-230 mg/kg/day, which should be met by standard feed volumes of either commercially fortified breast milk or preterm formulae. We sought ...
Chapman A K - - 2013
Objective:To assess chlorhexidine absorption and skin tolerability in premature infants, following skin antisepsis with 2% aqueous chlorhexidine gluconate (CHG) prior to peripherally inserted central catheter (PICC) placement.Study Design:Neonates less than 32 weeks gestation had skin cleansed with CHG prior to PICC placement. CHG concentrations were measured on serial blood samples. ...
Mohamed Shakir - - 2013
BACKGROUND: Hyperglycemia has recently been described as a risk factor for the development of retinopathy of prematurity (ROP), a proliferative vascular disease of the retina that primarily affects premature infants. This study was to evaluate the relationship of hyperglycemia and the development of ROP in premature infants less than 32 ...
Christensen Robert D - - 2013
BACKGROUND: Previous reports describe a statistical association, among very-low-birthweight (VLBW, <1500 g) neonates, between red blood cell (RBC) transfusion in the first days after birth and development of severe intraventricular (brain) hemorrhage (IVH). STUDY DESIGN AND METHODS: We hypothesized that after we established a neonatal intensive care unit (NICU) transfusion management ...
Kwatra Neha - - 2013
BACKGROUND: Hepatobiliary scintigraphy is highly sensitive for diagnosing biliary atresia; however, its specificity has varied in the literature from 35% to 97%. OBJECTIVE: The purpose of this study was to re-evaluate the accuracy of phenobarbital-enhanced hepatobiliary scintigraphy in differentiating biliary atresia from other causes of neonatal cholestasis. MATERIALS AND METHODS: ...
Blanken Maarten O MO Division of Pediatric Immunology and Infectious Diseases, University Medical Center Utrecht, Utrecht, The - - 2013
Respiratory syncytial virus (RSV) infection is associated with subsequent recurrent wheeze. Observational studies cannot determine whether RSV infection is the cause of recurrent wheeze or the first indication of preexistent pulmonary vulnerability in preterm infants. The monoclonal antibody palivizumab has shown efficacy in preventing severe RSV infection in high-risk infants. ...
Jensen Michael Ladegaard - - 2013
Preterm birth and formula feeding predispose to necrotizing enterocolitis (NEC) in infants. As mother's milk is often absent following preterm delivery, infant formula (IF) or human donor milk (HM) are frequently used as alternatives. We have previously shown that porcine and bovine colostrum (BC) provide similar NEC-protection in preterm piglets ...
Okazaki Mihoko - - 2013
Germinal matrix hemorrhages (GMHs) are typically seen in preterm neonates during the first 4 days of life. The authors encountered 2 children with late-onset GMH subsequent to ventriculoperitoneal (VP) shunt insertion for congenital hydrocephalus. Both children were delivered at full term with normal body weight, although they were compromised with ...
Wales Paul W - - 2013
Congenital ultra-short bowel syndrome (USBS) is a challenging problem with a poor outcome. We report a new management approach for USBS infants that attempts to optimize gut growth potential. We report five neonates with USBS in whom no correction was performed at primary surgery except placement of a gastrostomy (G) ...
Louis Deepak - - 2013
Abstract Objective: To study SMA doppler for predicting feed intolerance and necrotizing enterocolitis (NEC) in preterm SGA neonates with umbilical artery absent/reversed end diastolic flow (A/REDF) Study design: Prospective study. Patients: SGA neonates < 36 weeks born with antenatally diagnosed A/REDF formed cases. Those with normal Doppler formed controls. Primary ...
Sanghvi Kishore P - - 2013
AIM: To evaluate the feasibility of initiation of exclusive enteral feeds on first day of life in very low birthweight infants >1200 g. METHODS: Haemodynamically stable infants with birthweights 1200-1500 g irrespective of gestational age were randomized into two groups. Study group: Enteral feeds 80 mL/kg/day started within 1 h of birth and increased ...
Peirovifar Ali - - 2013
The selenium (Se) is an essential trace element that has a critical role in synthesis and activity of a number of selenoproteins with protective properties against free radical damage. This study was conducted to detect the serum Se concentration in very low birth weight (VLBW) preterm infants and its association ...
Lightburn M H - - 2013
Objective:To evaluate cerebral hemodynamics during dopamine treatment in hypotensive (mean arterial blood pressure (MABP)<gestational age) extremely low birth weight (ELBW) infants.Study Design:Continuous monitoring of cerebral blood flow velocity (CBFv), MABP and PCO2 was performed in hypotensive ELBW infants on the first day of life, beginning with an ∼15-min baseline reading ...
Kahramaner Zelal - - 2013
Abstract Objective: To investigate the relation between serum homocysteine levels and intraventricular hemorrhage (IVH) in preterm infants born to preeclamptic mothers. Methods: This study included 84 preterm infants (42 born to preeclamptic mothers and 42 born to normotensive healthy mothers) who were admitted to Izmir Tepecik Training and Research Hospital ...
Bahamondes Luis - - 2013
OBJECTIVE: To measure infants' breast milk intake and infant growth when their mothers initiated either combined oral contraceptive (COC), levonorgestrel-releasing intrauterine system, or etonogestrel-releasing implant, or copper intrauterine device (IUD) as a reference group. DESIGN: Prospective trial. SETTING: University-based hospital. PATIENT(S): On postpartum day 42, 40 women initiated a contraceptive ...
Farahani Leila Amiri - - 2013
Diaper dermatitis is one of the most common skin problems in infants and children, affecting between 7% and 35% of infants. This randomized clinical trial compared the efficacy of hydrocortisone 1% ointment with that of human breast milk in treating acute diaper dermatitis in infants ages 0 to 24 months. Infants ...
Oster Matthew E - - 2013
OBJECTIVE:To evaluate the trends in survival for infants with critical congenital heart defects (CCHDs) and to examine the potential impact of timing of diagnosis and other prognostic factors on survival.METHODS:We performed a retrospective population-based cohort study in infants born with structural congenital heart defects (CHDs) between 1979 and 2005 and ...
Yoder Bradley A - - 2013
Heated, humidified high-flow nasal cannula (HHHFNC) is commonly used as a noninvasive mode of respiratory support in the NICU. The safety and efficacy of HHHFNC have not been compared with other modes of noninvasive support in large randomized trials. The objective was to assess the efficacy and safety of HHHFNC ...
Stefanescu Beatrice M - - 2013
BACKGROUND: Neonatal ventilator-associated pneumonia (VAP) is associated with increased morbidity and mortality. In adults on mechanical ventilation, timed oral care decreases the frequency of VAP, but this approach has not been studied in neonates. OBJECTIVES: To evaluate the feasibility of a randomized trial of timed oral care with Biotene OralBalance® ...
Dawson Jennifer A - - 2013
AIM: Preterm infants begin the transition from gastric tube feeds to sucking feeds around 34 weeks' postmenstrual age. We compared physiological stability in two bottle feeding positions, cradle hold versus side lying in preterm infants. METHODS: Randomised crossover trial of infants <34 weeks' gestation at birth, ≥34 weeks' postmenstrual age ...
Doby Elizabeth H - - 2013
Sterile CSF pleocytosis occurs in febrile infants with UTI. Co-infection with enterovirus is a possible cause. We evaluated 57 infants with UTI and CSF pleocytosis. All had enterovirus testing by PCR. An explanation for pleocytosis was determined for 24 infants (42%). EV infection was detected in four and is an ...
Young Paul C - - 2013
BACKGROUND:Early readmissions of apparently healthy newborns after discharge from well baby nurseries (WBN) may reflect an inadequate assessment of the newborn's readiness for discharge.OBJECTIVE:To determine the frequency, causes, costs, and variations in rates of early rehospitalization of newborns discharged from 21 WBNs in 1 health care system.METHODS:We queried the Enterprise ...
Maruyama Kenichi - - 2013
BACKGROUND: The feeding interval is an important factor in enteral feeding of premature infants. We investigated postprandial intestinal blood flow in stable very-low-birth-weight infants fed at 2 h and 3 h intervals. METHODS: We used pulsed wave Doppler ultrasound to measure blood flow velocity of the superior mesenteric artery (SMA) ...
Shah P - - 2013
Abstract Background: Prolonged exposure to antibiotics (PEA) is associated with increased risk of necrotising enterocolitis (NEC), late onset sepsis (LOS), and death in preterm neonates. Aim: To evaluate PEA (≥4 days) for suspected (blood culture negative) sepsis and its association with NEC, LOS, and death in extremely preterm (EP: Gestation ...
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