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Lam Hugh Simon - - 2013
Early detection and treatment of infected preterm infants could decrease morbidity and mortality. Neutrophil CD64 has been shown to be an excellent early diagnostic biomarker of late-onset sepsis (LOS) and necrotizing enterocolitis (NEC). We aimed to study whether using CD64 as a daily surveillance biomarker could predict LOS/NEC before clinical ...
Neary Elaine - - 2013
Background: Few published data exist to guide interpretation of coagulation times in extremely premature infants. Objective: To determine coagulation reference ranges on day 1 of life in extremely premature infants. Methods: A retrospective review of day 1 coagulation tests was performed in 144 infants <27 weeks' gestation between 2004 and ...
Harder Björn C - - 2013
To report on the therapeutic effect of intravitreal low-dose bevacizumab for treatment for retinopathy of prematurity (ROP). The single-centre retrospective, non-comparative case series study included all infants who consecutively underwent intravitreal injection of 0.375 mg bevacizumab (0.03 ml) under light sedation in topical anaesthesia as therapy of ROP in zone I or ...
Mohamed Sarar - - 2013
Tyrosinemia type 1 (TT1) is an autosomal recessive disorder caused by deficiency of the enzyme fumarylacetoacetate hydrolase (FAH). TT1 usually presents in infancy with features suggestive of liver disease or with sepsis-like symptoms. We report two Saudi siblings with TT1. Case 1 was a male infant who presented at 2 ...
Ando Hitoshi - - 2013
Zonisamide, an antiepileptic drug, is excreted into breast milk, but information regarding the safety of breast-feeding while using this drug is limited. We present the cases of two nursing mothers, taking 300 and 100 mg/day zonisamide. At 5 days after delivery, the milk concentrations and relative infant doses of the drug ...
Sommers Ross - - 2013
Background:This study tested if measures of central nervous system (CNS) immaturity reflected by amplitude integrated EEG (aEEG) and associated clinical morbidities are determinants of length of hospitalization among late preterm infants born at 34 weeks.Methods:This was a prospective cohort study of infants with a gestational age of 34(0) to 34(6) ...
Gahalaut Pratik - - 2013
Vitamin K deficiency bleeding (VKDB) disorder is an uncommon entity, which occurs due to inadequate activity of vitamin K-dependant coagulation factors. An 8-months-old exclusively breast-fed male infant presented with multiple, purpuric and nodular non-collapsible swellings on trunk of 4 days duration. Investigations revealed raised activated partial thromboplastin time and prothrombintime. ...
Puttgen Katherine B - - 2013
We sought to determine the effect of propranolol on cardiovascular and blood glucose parameters in infants with symptomatic infantile hemangiomas who were hospitalized for initiation of treatment, and to analyze adverse effects of propranolol throughout the course of inpatient and outpatient treatment. A retrospective cohort analysis was performed on 50 ...
Zagólski Olaf - - 2013
The study sought to evaluate the influence of gastroesophageal reflux disease (GERD) and allergy on subacute rhinitis in infants. Mothers of 74 infants with subacute rhinitis completed the Infant Gastroesophageal Reflux Questionnaire Revised. Participants with GERD were randomized to undergo one of the following regimens for 10 days: use of ...
Ombeva Om - - 2013
The World Health Organization (WHO) reports estimate that 85% of newborn deaths are due to infections, prematurity and fetal distress. These conditions are risk factors for upper GI bleeding (UGIB) in sick neonates. UGIB is associated with poor neonatal outcomes such as prolonged hospitalisation and poor weight gain. The magnitude ...
Baqui Abdullah H AH Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA. - - 2013
Because access to care is limited in settings with high mortality, exclusive reliance on the current recommendation of 7-10 days of parenteral antibiotic treatment is a barrier to provision of adequate treatment of newborn infections. We are conducting a trial to determine if simplified antibiotic regimens with fewer injections are ...
Zaidi Anita K M AK Department of Paediatrics and Child Health, Aga Khan University, Karachi, - - 2013
Infection in young infants is a major cause of morbidity and mortality in low-middle income countries, with high neonatal mortality rates. Timely case management is lifesaving, but the current standard of hospitalization for parenteral antibiotic therapy is not always feasible. Alternative, simpler antibiotic regimens that could be used in outpatient ...
- - 2013
The World Health Organization recommends hospitalization and injectable antibiotic treatment for young infants (0-59 days old), who present with signs of possible serious bacterial infection. Fast breathing alone is not associated with a high mortality risk for young infants and has been treated with oral antibiotics in some settings. This ...
Bruno Christie J - - 2013
Few data regarding causes and outcomes of haemorrhagic stroke (HS) in term neonates are available. We characterised risk factors, mechanism and short-term outcomes in term and late preterm neonates with acute HS. Prospective cohort. Single-centre tertiary care stroke registry. Term and late preterm neonates (≥34 weeks gestation), born 2004-2010, with ...
Brownfoot Fiona C - - 2013
Despite the widespread use of antenatal corticosteroids to prevent respiratory distress syndrome in preterm infants, there is currently no consensus as to the type of corticosteroid to use; nor the dose, frequency, timing of use or the route of administration. To assess the effects of different corticosteroid regimens for women ...
da Silva Simone Aparecida Basso - - 2013
Abstract Aims: Compare the need for neonatal resuscitation procedures between newborn infants with and without meningomyelocele (MMC). Results: This retrospective case-control study included 94 neonates with MMC, defined as open spinal dysraphism with exposure of nervous tissue, and 94 controls without malformations, paired with MMC infants by gender, mode of ...
Reeves Travis D - - 2013
To determine the dimensions of the nasal cavity in infants with congenital pyriform aperture stenosis (CPAS). The nasal cavities of seven children with CPAS were identified and were compared to the nasal cavities of 13 neonates (<30 days old) who had received CT scans for other indications. The width of ...
Raets Marlou M A - - 2013
Purpose:To report the incidence of cerebral sinovenous thrombosis (CSVT) in a prospective cohort of preterm infants with a gestational age of less than 29 weeks.Materials and Methods:The local medical ethics review board approved this study, and written parental consent was obtained. Preterm infants with a gestational age of less than ...
Kempley Stephen - - 2013
To describe feeding and gastrointestinal outcomes in growth-restricted infants <29 weeks' gestation and to determine the rate of feed advancement which they tolerate. Analysis of prospectively collected data from a randomised feeding trial, the Abnormal Doppler Enteral Prescription Trial (ADEPT). 54 neonatal units in the UK and Ireland. 404 preterm, ...
Papoff P - - 2013
The objective was to review and compare outcomes after tongue-lip adhesion (TLA) and mandibular distraction osteogenesis (MDO) in infants with severe breathing difficulties related to Pierre Robin sequence (PRS). A single-centre retrospective (2002-2012) study was carried out; 18 infants with severe breathing difficulties related to PRS resistant to conservative treatment, ...
Hirfanoglu Ibrahim M - - 2013
Gamma-glutamyltransferase (GGT) is commonly measured in newborn infants as a sensitive liver function test, however reference ranges mostly based on early studies including relatively small number of patients. The aim of this study was to emphasise recently changed GGT values due to changed newborns profile admitted to neonatal intensive care ...
Giusti Delphine - - 2013
Measles is a highly contagious viral infection causing congenital infections with a risk of neurological complications in the newborn. Two cases of measles, which occurred in pregnant women within 14 days before the delivery, are described. Mother-to-child transmission of the virus was documented in the newborns either by RT-PCR in ...
Collins C L - - 2013
The objectives of this study were (1) to devise a nasal trauma score for preterm infants receiving non-invasive respiratory support, (2) to compare the incidence of nasal trauma in preterm infants <32 weeks gestation randomised to either nasal continuous positive airway pressure (NCPAP) or heated humidified high-Flow nasal cannulae (HHHFNC), in ...
Loui Andrea - - 2013
Abstract Aim: To assess the impact of a high enteral protein nutrition strategy in human milk-fed very low birth weight (VLBW) infants (<1500 g) on growth during the first 5 weeks of life. Design: Weight, length and head circumference of VLBW infants were recorded after introduction of a high protein ...
Surran B - - 2013
Objective:To compare the efficacy of clonidine versus phenobarbital in reducing morphine sulfate treatment days for neonatal abstinence syndrome (NAS).Study Design:Prospective, non-blinded, block randomized trial at a single level III NICU (Neonatal Intensive Care Unit). Eligible infants were treated with a combination of medications as per protocol. Primary outcome was treatment ...
Moenkemeyer Florian - - 2013
To investigate the relationship between early right ventricular function measured by tissue Doppler imaging and early outcome measures in newborn infants with congenital diaphragmatic hernia. Retrospective cohort study. Surgical neonatal ICU within a regional pediatric center. Twenty newborn infants with congenital diaphragmatic hernia. None. Analysis of serial echocardiograms in a ...
Hirata Katsuya - - 2013
Objective The aim of this article is to evaluate the accuracy, precision, and safety of transcutaneous carbon dioxide tension (TcPCO2) monitoring at different electrode temperatures in preterm infants in the early postnatal period.Study Design A total of 26 neonates with a median birth weight of 974 g (432-1,694 g) and ...
Oh Jung Wha - - 2013
A 2-day-old male infant was referred to hospital because he was continually moaning. Massive pneumoperitoneum was observed on plain radiographs on the day of admission. This case is unique in that the massive pneumoperitoneum with meconium-stained peritoneal fluid was not associated with any evidence of bowel perforation seen on laparotomy.
Watanabe Toshihiko - - 2013
Milk curd syndrome was first reported in the 1960s, but was gradually forgotten because of its low incidence thereafter. This condition in pre-term infants has been reported over the last decade and has again attracted neonatologists' attention. The present report describes a pre-term infant with milk curd syndrome. Abdominal distension ...
van den Berg Jolice P - - 2013
Infections are common in preterm infants and cause differences in cytokine levels. Aim of this study was to measure cytokine levels in preterm infants during the first year of life and to determine the effect of feeding a specific non-digestible carbohydrate mixture (scGOS/lcFOS/pAOS). Furthermore, other perinatal factors in relation to ...
Frenette Priscilla - - 2013
Objectives: To compare risks of infection and prematurity-related outcomes according to latency periods among women with preterm prelabour rupture of membranes (PPROM). Methods: Women with PPROM occurring between 24+0 and 36+6 weeks of gestation were identified from a provincial population-based perinatal database in Nova Scotia. The primary outcomes included composite ...
Zhang Linjie - - 2013
Airway oedema and mucus plugging are the predominant pathological features in infants with acute viral bronchiolitis. Nebulised hypertonic saline solution may reduce these pathological changes and decrease airway obstruction. To assess the effects of nebulised hypertonic (≥ 3%) saline solution in infants with acute viral bronchiolitis. We searched CENTRAL 2013, ...
Tsai Ming-Horng - - 2013
Late-onset sepsis (LOS) is a common complication in the neonatal intensive care unit (NICU). We aimed to describe the epidemiology, clinical characteristics, and risk factors for adverse outcome in neonates with LOS. We conducted a cohort study of all neonates with LOS at the NICU of a Tertiary Taiwan Medical ...
Saadah Loai M - - 2013
To identify subgroups of premature infants who may benefit from palivizumab prophylaxis during nosocomial outbreaks of respiratory syncytial virus (RSV) infection. Retrospective analysis using an artificial intelligence model. Level IIIB, 35-bed, neonatal intensive care unit (NICU) at a tertiary care hospital in the United Arab Emirates. One hundred seventy six ...
Sellmer Anna - - 2013
To assess the association between a patent ductus arteriosus (PDA) on day 3 of life and severe morbidity and mortality. Cohort study. Neonatal Intensive Care Unit, Aarhus University Hospital, Denmark. All neonates with a gestational age less than 32 weeks admitted from 2010 to 2012. All neonates (n=183) were routinely ...
Chang Yun Hee - - 2013
Outcomes after surgical ligation of patent ductus arteriosus (PDA) in preterm infants are often complicated by prematurity associated comorbidities. The Aristotle comprehensive complexity score (ACCS) has been proposed as a useful tool for complexity adjustment in the analysis of outcome after congenital heart surgery. The aims of this study were ...
Li Rong - - 2013
ABSTRACT Purpose: Maturity is a critical factor in the pathogenesis of retinopathy of prematurity (ROP). One widely used method for studying this condition is that of oxygen-induced retinopathy (OIR). The general conditions of an OIR term animal, both at the time of birth and following birth, differ from those of ...
Prempunpong Chatchay - - 2013
To investigate the effect of the therapeutic hypothermia (TH), used in infants with moderate or severe HIE, on fluid balance and incidence of hyponatremia. Retrospective cohort study of moderate and severe HIE infants before (pre) and after (post) TH implementation. Daily fluid and electrolytes intake/output was collected from the medical ...
Brown Nicole - - 2013
Infantile botulism is the result of ingestion of Clostridium botulinum spores, and is the most common form of infection with botulism in the United States. Ninety percent of cases occur in infants <6 months old. The infants typically present with vague symptoms such as hypotonia and poor feeding. This article reports ...
Coats Debra - - 2013
Thiamine deficiency is common in parts of Asia and causes beriberi. Pharmacokinetics of thiamine in deficient populations are unknown. We characterized thiamine pharmacokinetics in Cambodian mothers and their breastfed infants. Total plasma thiamine, whole-blood thiamine diphosphate (TDP), and breast milk breast milk total thiamine were measured in 16 healthy Cambodian ...
Davidson Jesse - - 2013
Background:The utility of procalcitonin and C-reactive protein (CRP) as infectious biomarkers following infant cardiothoracic surgery is not well defined.Methods:We designed a prospective cohort study to evaluate procalcitonin and CRP after infant cardiothoracic surgery. Procalcitonin and CRP were drawn pre-operatively and 24/72 hours post-operation or daily in delayed sternal closure patients. ...
Chang Pi-Feng - - 2013
Background:The aim of this study was to establish a model to identify the term breast-fed infants who are at risk of developing significant neonatal hyperbilirubinemia.Method:A prospective study was designed to investigate the effects of birth body weight, mode of delivery, cephalohematoma, glucose-6-phosphate dehydrogenase (G6PD) deficiency, predischarge total serum bilirubin, variant ...
Truong Dongngan T - - 2013
Echocardiography is the mainstay of preoperative arch imaging in infants with coarctation of the aorta. In simple coarctation, repair by way of sternotomy or thoracotomy is often determined by echocardiographic transverse arch measurements. The degree of arch hypoplasia that is prohibitive to repair by way of thoracotomy is unknown. Clinical ...
Monangi Nagendra - - 2013
To evaluate vitamin D (vitD) status in early preterm infants (EPTIs) at birth and during birth hospitalisation on current vitD intake. Serum 25-hydroxyvitamin-D [25(OH)D] concentrations, vitD intake and risk factors for low vitD status were assessed in 120 infants born at ≤32 weeks gestation. Mean (SD) serum 25(OH)D at birth ...
Runge Stine Bjerrum - - 2013
To examine the association between occupational lifting during pregnancy and preterm birth. The risk of preterm birth was estimated for total burden lifted per day and number of medium and heavy loads lifted per day. In a study population of 62 803 pregnant women enrolled to the Danish National Birth ...
Padula M A - - 2013
Objective:To characterize the treatments and short-term outcomes in infants with severe bronchopulmonary dysplasia (sBPD) referred to regional neonatal intensive care units.Study Design:Infants born <32 weeks' gestation with sBPD were identified using the Children's Hospital Neonatal Database. Descriptive outcomes are reported.Result:A total of 867 patients were eligible. On average, infants were ...
McElrath T - - 2013
To compare the early postnatal pattern of systemic inflammation in growth-restricted infants born before the 28(th) week of gestation to that of appropriately grown peers. We measured the concentrations of 25 inflammation-related proteins in blood spots collected from 939 newborns during the first 2 postnatal weeks. We calculated the odds ...
Borschel Marlene W - - 2013
A masked, randomized, parallel growth study was conducted in infants fed an amino acid-based formula (AF) or an extensively hydrolyzed casein-based formula (HF). Infants were enrolled between 0 and 9 days and studied to 112 days of age. Growth, formula intake, stool patterns, and serum albumin concentrations were assessed. There ...
Hornik Christoph P - - 2013
Carbapenems are commonly used in hospitalized infants despite a lack of complete safety data and associations with seizures in older children. We compared the incidence of adverse events in hospitalized infants receiving meropenem versus imipenem/cilastatin. We conducted a retrospective cohort study of 5566 infants treated with meropenem or imipenem/cilastatin in ...
Lee Soon Min - - 2013
Purpose: We hypothesized that parenteral nutrition associated cholestasis (PNAC) would be more severe in small for gestational age (SGA) compared with appropriate for gestational age (AGA) very low birth weight (VLBW) infants. Materials and Methods: Sixty-one VLBW infants were diagnosed as PNAC with exposure to parenteral nutrition with elevation of ...
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