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Williams Flr F University of Dundee, Dundee, - - 2014
The developing thyroid is sensitive to iodine overload with exposure potentially resulting in goitre and/or hypothyroidism. The British National Formulary (BNF) lists neonates <32 weeks gestation and infants under 1.5 Kg as contra-indications for the use of povidone-iodine for skin disinfection, and recommends its avoidance during pregnancy and breast feeding. ...
Granger C C NICU, Southern General Hospital and Royal Hospital for Sick Children, Glasgow, - - 2014
Admission of babies to NICU for medical care involves the separation of mothers and babies. We questioned what proportion of term babies were admitted in our institution and what interventions they required. We retrospectively reviewed the NICU database to identify all babies ≥ 37 weeks gestation admitted to our tertiary ...
Beake Mj M Neonatal Unit, Birmingham Women's Hospital NHS Trust,Birmingham, - - 2014
: A 32 year old woman presented at 29 weeks gestation with reduced fetal movements and abdominal pain to her local hospital. An ultrasound scan revealed gross fetal hydrops secondary to congenital complete heart block (cCHB) with a ventricular rate of 40 bpm. The baby was transferred in-utero to the ...
Gale C C Section of Neonatal Medicine, Chelsea and Westminster Hospital Campus, Imperial College London, London, - - 2014
Direct measurement of adipose tissue using magnetic resonance imaging (MRI) is increasingly used to characterise body composition. Optimal techniques for adjusting direct measures of infant adipose tissue remain to be determined. To explore the relationships between body size and directly measured total and regional adipose tissue volume (ATV), and the ...
Badii S S University College London NHS Trust and University College London, London, - - 2014
Lactate (Lac) / N-acetyl-aspartate (Naa) peak area ratio measured at long echo time on proton magnetic resonance spectroscopy (1H MRS) in the thalamus is a robust biomarker of outcome between day 5-14 in babies presenting with neonatal encephalopathy (NE).(1) Previous studies have been done at 2.35 and 1.5 Tesla; a ...
Philpott A A Southern West Midlands Newborn Network, Birmingham, UK West Midlands Neonatal Transfer Service, Birmingham, UK Staffordshire, Shropshire and Black Country Newborn Network, Stoke, - - 2014
Therapeutic Hypothermia (TH) improves neurological outcomes for a selected neonatal population. The need for on-going education in commencing TH was recognised by the Southern West Midlands (SWM), Staffordshire, Shropshire and Black Country (SSBC) Neonatal Networks and their neonatal transport team (WMNTS). The first of four study days was designed and ...
Alia R R Leeds Teaching Hospitals NHS Trust, Leeds, - - 2014
: This is the first case report in the literature describing the long term prognosis of liver necrosis caused by TPN extravasation in an extremely preterm infant. A 26 weeks gestation preterm boy was born spontaneously with a birth weight of 1.0 kg. He had a UVC inserted soon after ...
Soni R R Leeds Teaching Hospitals, NHS Trust, Leeds, - - 2014
: A baby boy was born at 31 weeks gestation via caesarean section following premature rupture of membranes and poor CTG. The pregnancy had been complicated by severe polyhydramnios from 24 weeks of gestation. Amnio-drainage was undertaken at 27 weeks followed by a course of Sulindac (NSAID, Non steroidal anti ...
Frederiksen Hanne H University Department of Growth and Reproduction, Rigshospitalet, Faculty of Health Sciences, Copenhagen, - - 2014
Some phthalates have shown anti-androgenic effects in rat offspring. Premature infants may be exposed to high amounts of specific phthalates during hospitalization and thus are potentially at risk. We evaluated longitudinal phthalate exposure and metabolism in full term (FT) and preterm (PT) infants. Fifty-eight FT and 67 PT (gestational age ...
Pruikkonen H H Department of Paediatrics, University of Oulu, and University Hospital of Oulu, Oulu, - - 2014
This study examined the need for, and timing of, major medical interventions (MMIs) in infants under six-months-of-age with bronchiolitis. We reviewed the medical records of 353 children who visited our emergency department with bronchiolitis. MMI was defined as the need for any of the following interventions during admission: supplementary oxygen, ...
Aly Hany H Department of Neonatology, the George Washington University and Children's National Medical Center, Washington DC, - - 2014
Abstract Objectives: Late preterm infants are the fastest growing segment of the premature infant population in the U.S. However, it is not known if demographic and clinical factors can impact the length of hospital stay (LOS) in this population. The objectives of this study are to determine a) factors associated ...
Korkmaz Hüseyin Anıl - - 2014
Abstract Aim: To assess the efficiency of oral desmopressin lyophilisate (ODL) in neonatal central diabetes insipidus (CDI). Methods: The characteristics of four newborns with CDI treated with ODL were evaluated. Results: Four newborns with polyuria and hypernatremia were included [male, 2 (50%); mean postnatal age, 19±17 days]. At the time ...
Fernández David D Interdepartmental Doctoral Program in Anthropological Sciences, Stony Brook University, Stony Brook, New - - 2014
An accurate description of reproductive characteristics and ovarian endocrinology is necessary to address questions about the reproductive strategies and life history of a species and for meaningful, cross species analyses. Here we used analysis of fecal estradiol (fE) and behavioral observations to determine for the first time the reproductive characteristics ...
Stojanović Vesna V Intensive Care Unit, Institute for Child and Youth Health Care of Vojvodina, Medical Faculty, University of Novi Sad, Hajduk Veljkova 10, Novi Sad, 21000, Serbia, - - 2014
The factors that contribute to the development of acute kidney injury (AKI) and treatment outcome among prematurely born neonates are not clearly understood. This retrospective study included 150 prematurely born neonates. AKI was defined as an increase of serum creatinine levels ≥0.3 mg/dl compared to basal values. The majority of neonates ...
Penn Alexander H AH *Departments of Bioengineering †Pediatrics ‡Psychology, University of California San Diego, La Jolla, CA 92093-0412 §Rady Children's Hospital San Diego2, San Diego, CA - - 2014
Fat is digested in the intestine into free fatty acids (FFAs), which are detergents and therefore toxic to cells at micromolar concentration. The mucosal barrier protects cells in the adult intestine, but this barrier may not be fully developed in premature infants. Lipase-digested infant formula, but not fresh human milk, ...
Doyle Lex W LW Department of Obstetrics and Gynaecology, The University of Melbourne, Parkville, Victoria, Australia, - - 2014
Many preterm infants who survive go on to develop chronic lung disease. This is probably due to persistent inflammation in the lungs. Corticosteroids have powerful anti-inflammatory effects and have been used to treat established chronic lung disease. However, it is unclear whether any beneficial effects outweigh the adverse effects of ...
Doyle Lex W LW Department of Obstetrics and Gynaecology, The University of Melbourne, Parkville, Victoria, Australia, - - 2014
Chronic lung disease remains a major problem in neonatal intensive care units. Persistent inflammation in the lungs is the most likely underlying pathogenesis. Corticosteroids have been used to either prevent or treat chronic lung disease because of their potent anti-inflammatory effects. To examine the relative benefits and adverse effects of ...
Unger Sharon - - 2014
Provision of mother's own milk is the optimal way to feed infants, including very low birth weight infants (VLBW, <1500 g). Importantly for VLBW infants, who are at elevated risk of neurologic sequelae, mother's own milk has been shown to enhance neurocognitive development. Unfortunately, the majority of mothers of VLBW ...
Espiritu Nora N Department of Pediatrics, Hospital Nacional Dos de Mayo, Lima, Peru; Department of Pulmonology, Hospital Nacional Dos de Mayo, Lima, Peru; "Santa Martha" Health Centre, Ministerio de Salud (MINSA), Lima, Peru; Department of Infectious Diseases and Immunity, Imperial College London, London, United Kingdom; Laboratory of the Universidad Peruana Cayetano Heredia, Lima, Peru; Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, - - 2014
This article presents a case of multidrug-resistant tuberculosis (TB) in a Peruvian infant. His mother was diagnosed with disseminated TB, and treatment commenced 11 days postpartum. The infant was diagnosed with TB after 40 days and died at 2 months and 2 days of age. Congenital transmission of TB to ...
Dardas Majd M Department of Pediatrics, Division of Neonatology, University of Rochester Medical Center, Rochester, NY, - - 2014
Background:Development of the intestinal microbiome in preterm infants has significant impact on infant health. Our objective was to determine if duration of antibiotics within the first 10 and 30 days after birth affects the intestinal microbiome.Methods:Subjects were 24 0/7-31 6/7 weeks of gestational age who received =50% breast milk and ...
Huang Lisha L *Department of Pediatrics, Academic Medical Centre, Emma Children's Hospital, Amsterdam, The Netherlands †Department of Pediatrics, VU University Medical Centre, Amsterdam, The Netherlands ‡Department of Pediatrics, Division of Neonatology, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands §Department of Pediatrics, Division of Neonatology, Children's Hospital of Fudan University, Shanghai, P.R. China ||UMC st. Radboud Nijmegen, The Netherlands ¶Department of Methodology and applied Biostatistics, VU University Medical Centre, Amsterdam, The Netherlands #Department of Pediatrics, Division of Gastroenterology, Children's Hospital of Fudan University, Shanghai, P.R. - - 2014
Tryptophan is not only an amino acid essential to protein synthesis, it also serves as a precursor in two important metabolic pathways: the serotonin and the kynurenine pathways. Tryptophan is related to sleeping patterns. The objective was to determine the tryptophan requirement of term infants using the Indicator Amino Acid ...
Shinde Suvarna S Department of Neonatology, Surya Childrens Hospital, Santacruz West, Mumbai, India. Correspondence to: Dr Nandkishor S Kabra, Department of Neonatology, Surya Childrens Hospital, Mangal Ashirwad, Junction of S V Road and Dattatraya Road, Santacruz West, Mumbai 400054 India. - - 2014
To compare the efficacy of glycerin suppository versus no suppository in preterm very-low-birthweight neonates for improving feeding tolerance. Randomized controlled trial. Level III neonatal unit from Mumbai, India. 50 very-low-birthweight (birth weight between 1000 to 1500 grams)preterm (gestational age between 28 to 32 weeks) neonates randomized to glycerine suppository (n=25) ...
Laughon Matthew M MM Division of Neonatal-Perinatal Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, North - - 2014
Objective Diuretics are often prescribed off-label to premature infants, particularly to prevent or treat bronchopulmonary dysplasia. We examined their use and safety in this group. Study Design Retrospective cohort study of infants < 32 weeks gestation and < 1,500 g birth weight exposed to diuretics in 333 neonatal intensive care units from 1997 to 2011. We examined ...
Kim Hochang H From the Dongguk University Gyeongju - - 2014
We describe an infant with respiratory distress due to bilateral dacryocystoceles and dacryocystitis who was successfully treated with urgent bilateral endoscopic marsupialization.A male infant was brought to our outpatient department 7 days after birth, with red, acutely inflamed swellings near the medial canthal area of both eyes. From birth, there ...
Seitz Jolynn J St Joseph Mercy Hospital, Ann Arbor, - - 2014
Inadequate trophoblast invasion has been postulated as a major contributor to preterm birth. Maternal implantation biomarker, human chorionic gonadotropin (hCG), has been variably predictive of preterm birth. This study allows precise comparison of maximal hCG values exactly at 56 days of gestation in twin gestations conceived with in vitro fertilization. ...
Tergestina Mintoo M *Department of Neonatology †Department of Clinical Biochemistry ‡Department of Biostatistics, Christian Medical College, Vellore, Tamil Nadu, - - 2014
The aim of this study was to assess vitamin D status of preterm babies at birth and adequacy of daily supplementation with vitamin D. This prospective cohort study recruited 111 preterm babies, 25 to 32 weeks' gestation from a tertiary care perinatal center in south India. Cord blood was assayed ...
Armanian Amir-Mohammad AM Department of Pediatrics, Division of Neonatology, Child Growth and Development Research Center, Isfahan University of Medical Sciences, Isfahan, - - 2014
The objective of this study is to assess the safety and preventative effects of aminophylline on the incidence of chronic lung disease (CLD) in very premature infants. This was a long follow-up randomized clinical trial. The prophylactic effect of aminophylline on the incidence of CLD was investigated in very premature ...
Platt M J MJ Norwich Medical School, University of East Anglia, Norwich NR4 7TJ, UK. Electronic address: - - 2014
Preterm birth is defined as birth before 37 completed weeks gestation, and it is estimated that each day, across the world over 41,000 infants are born before this gestational age. The risk of adverse consequences declines with increasing gestational age. While this paper focuses on the consequences of preterm birth, ...
Eriksen Beate Horsberg BH Department of Paediatrics, Møre and Romsdal Hospital Trust, NO-6026 Ålesund, Norway; Department of Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway. Electronic address: - - 2014
Sparse knowledge exists on the differences in cardiac function between term and preterm infants. This study examines the impact of heart size, gestational age and postnatal maturation on myocardial function. To assess and compare serial echocardiographic indices of myocardial function in term and moderately preterm infants. Longitudinal, prospective, observational echocardiographic ...
Walker M W MW Division of Neonatology, Children's Hospital, Greenville Health System, Greenville, SC, - - 2014
Objective:The primary aim of the study was to determine how the risk of adverse outcomes was related to the duration of the latency period and gestational age at birth following preterm premature rupture of the fetal membranes (PPROM).Study Design:Retrospective review of infants discharged from 330 neonatal intensive care units. We ...
Tsai Wen-Hui WH Institute of Clinical Medicine, National Cheng Kung University College of Medicine, Tainan 701, Taiwan; Division of Neonatology, Chi Mei Medical Center, Tainan 710, - - 2014
Mechanical ventilation for preterm infants independently contributes to poor neurodevelopmental performance. However, few studies have investigated the association between the duration of mechanical ventilation and the risk for various developmental disorders in extremely low birth weight (ELBW) (<1000g) infants. Using a large nationwide database, we did a 10-year retrospective follow-up ...
Cetinkaya Merih M Department of Neonatology, Kanuni Sultan Suleyman Training and Research Hospital, Istanbul, Turkey. Electronic address: - - 2014
sE-selectin has recently been suggested as a surrogate marker for prediction of ROP development. The possible role of serial plasma sE-selectin measurements in early prediction and diagnosis of ROP was evaluated. Prospective observational study SUBJECTS: Forty six preterm infants aged <34weeks of gestation and weighing <1500 g were enrolled. Of ...
Marinelli Kathleen A KA 1The Connecticut Human Milk Research Center, Hartford, CT, - - 2014
Background:Use of donor milk (DM) to supplement mother's own milk (MOM) in the neonatal intensive care unit (NICU) is steadily increasing based on health and developmental benefits to premature infants. A paucity of data exists documenting the effect of DM use on the diet of very low birth weight (VLBW) ...
McCormick Michael E ME Division of Pediatric Otolaryngology, Medical College of Wisconsin and Children's Hospital of Washington, Milwaukee, - - 2014
Importance: We describe management of an infant with chronic aspiration as a result of severe and rarely-described laryngeal dysgenesis. Observations: A neonate with severe maldevelopment of the laryngeal structures required tracheostomy for respiratory distress on day-of-life one, but the patient continued to have aspiration pneumonias. After failing to improve with ...
Wong Jonathan J Department of Pediatrics, Kingston General Hospital, Kingston, Ontario, - - 2014
Objective To compare neonatal outcomes between infants who received inotropes and those who did not, and identify variation in inotrope use. Study Design Retrospective review of data from neonates < 29 weeks gestation collected by the Canadian Neonatal Network during 2003 to 2010. After controlling for confounders and maternal/infant characteristics, rates of mortality and ...
Fernández C L A CL Instituto Nacional de Perinatología, - - 2014
Objective:To compare the incidence of oxygen dependency in SIBEN neonatal units while adjusting for altitude.Study Design:We reviewed the charts of infants who were1500 g at birth, admitted to six neonatal intensive care units (NICUs) near sea level and in seven NICUs at varying altitudes above sea level from the SIBEN network ...
Ichinomiya Kenji K Department of Neonatology, Gunma Children's Medical Center, 779 Shimohakoda, Hokkitsu, Shibukawa, Gunma 377-8577, - - 2014
Despite the early use of phototherapy and exchange transfusion in premature infants based on their levels of total serum bilirubin (TSB), the reemergence of kernicterus has been reported. The purpose of this study was to assess the validity of using TSB levels as the criterion for phototherapy in extremely-low-birth-weight infants ...
Gaballah Marian M Department of Radiology, Children's Hospital of Philadelphia, Perelman School of Medicine of the University of Pennsylvania, 3401 Civic Center Blvd., Philadelphia, PA 19104. Electronic address: - - 2014
To describe experience with the use of ultrasound (US)-guided placement and tip position confirmation for direct saphenous and single-incision tunneled femoral noncuffed central venous catheters (CVCs) placed in neonates and infants at the bedside. A retrospective review of the interventional radiology (IR) database and electronic medical records was performed for ...
Lasekan John B JB a Pediatric Nutrition R&D, Abbott Nutrition, Abbott Laboratories , Columbus , - - 2014
Objective: Spit-up (regurgitation) reduction with prethickened milk protein-based infant formulas containing rice starch has been clinically demonstrated in infants with heavy spit-ups but not in otherwise healthy normal infants with common spit-ups. The objective of this study was to evaluate growth, gastrointestinal tolerance, and efficacy to reduce common spit-up in ...
Ansary A A Department of Neonatology, Royal Hospital for Sick Children (Yorkhill), Dalnair Street, Glasgow G3 8SJ, United Kingdom. - - 2014
Venlafaxine, a serotonin and norepinephrine reuptake inhibitor, is increasingly used in pregnant women with pre-existing depression who require continued treatment. However, its in uteroeffects on the developing fetus are not clear. Herein, we report the unusual presentation of venlafaxine withdrawal in a female preterm baby of 29 weeks gestation, who ...
Aunsholt Lise L Hans Christian Andersen Children's Hospital, Odense University Hospital, Odense, - - 2014
Background: Necrotizing enterocolitis and congenital gastrointestinal malformations in infants often require intestinal resection, with a subsequent risk of short bowel syndrome (SBS). We hypothesized that immediate intestinal adaptation following resection of the distal intestine with placement of a jejunostomy differs between preterm and term neonates. Methods: Preterm or term piglets ...
Berger Jessica J Division of Perinatal Medicine, Department of Pediatrics, Yale University School of Medicine, New Haven, - - 2014
Objective The objective of this study was to assess rates of bronchopulmonary dysplasia (BPD) and BPD/death in infants first extubated between day of life (DOL) 1 to 3 versus 4 to 7, 8 + , and impact of reintubation. Study Design We included infants with gestational age ≤ 28 weeks, birth weight ≤ 1,000 g, and intubation ...
Tubbs-Cooley Heather L HL Research in Patient Services, Division of Nursing, Cincinnati Children's Hospital Medical Center, Cincinnati, - - 2014
Objective To examine the association of missed oral feeding opportunities among preterm infants with achievement of full oral feedings and length of hospitalization. Study Design A secondary analysis of clinical trial data was conducted. Study infants included in the analysis (N = 89) were randomized to one of four standardized feeding progression approaches; detailed ...
Jeziorsky Eric E Department of Pediatrics, Montpellier University Hospital, Montpellier, France; INSERM U1058, Montpellier 1 University, Montpellier, - - 2014
The human parechoviruses (HPeVs) were recently recognized as important viral pathogens involved in various illnesses in young children. However, routine detection is not performed in most clinical laboratories. Therefore, in this study, we aim to assess the relevance of HPeV detection in cerebrospinal fluid (CSF) of infants, according to clinical ...
Besançon Alix A A Besançon, Endocrinologie-Diabétologie-Gynécologie Pédiatrique, Hopital Necker, PARIS, - - 2014
Hyperthyroidism in neonates born to mothers with Graves' disease (GD) can be associated with significant morbidity and mortality but is still overlooked by clinicians. Management of neonatal hyperthyroidism would be improved by a better understanding of the predictive factors involved. The aim of this study was to evaluate the course ...
Borschel Marlene W MW 1Abbott Nutrition, Abbott Laboratories, Columbus, OH, - - 2014
Extensively hydrolyzed formulas present a complex matrix subject to adverse conditions during manufacture that could influence growth and tolerance of infants fed these formulas. A masked, randomized, parallel growth study was conducted in infants fed a ready-to-feed (RTF) or powdered (PWD) form of an extensively hydrolyzed casein-based formula. Infants were ...
Senniappan Senthil S From the Developmental Endocrinology Research Group, Clinical and Molecular Genetics Unit, Institute of Child Health, University College London (S.S., P.S., V.A., K.H.), and the Departments of Paediatric Endocrinology (S.S., P.S., V.A., K.H.) and Histopathology (D.P., M.A.), Great Ormond Street Hospital for Children, London, and the Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter (S.F., S.E.) - all in the United Kingdom; the Department of Pathology, University of California, San Francisco, San Francisco (S.A.); and the Department of Pathology and Laboratory Medicine, University of Texas Medical School at Houston, Houston (N.T., - - 2014
Hyperinsulinemic hypoglycemia is the most common cause of severe, persistent neonatal hypoglycemia. The treatment of hyperinsulinemic hypoglycemia that is unresponsive to diazoxide is subtotal pancreatectomy. We examined the effectiveness of the mammalian target of rapamycin (mTOR) inhibitor sirolimus in four infants with severe hyperinsulinemic hypoglycemia that had been unresponsive to ...
Bender Jeffrey M JM Department of Pediatrics, Kaiser Permanente, Los Angeles Medical Center, Los Angeles, California; Division of Pediatric Infectious Diseases, Department of Pediatrics, Children's Hospital Los Angeles, Los Angeles, - - 2014
Human rhinovirus (HRV) is a common cause of respiratory illness in children. The impact of HRV infection on 1- to 90-day-old infants is unclear. We hypothesized that HRV infection would be clinically similar to respiratory syncytial virus (RSV) infection in the hospitalized infants. We conducted a retrospective study of hospitalized ...
Wei Yi-Hsuan YH Division of Neonatology, Department of Pediatric, Changhua Christian Hospital, Changhua, - - 2014
Pneumothorax is more frequent in the neonatal period, especially among premature infants. Pigtail catheters have been shown to be as effective as and less invasive than traditional chest tubes in adults; however, data regarding premature infants are limited. We aimed to compare the efficacy, safety, and complications associated with the ...
De Jong Grant D GD Ecological Division, GEI Consultants Inc., Denver, CO, - - 2014
Urogenital myiasis of newborn infants, although rare, is usually considered to indicate neglect due to attraction of flies to feces; however, infant feces have not been determined to attract insects. Human meconium and breast-fed-infant feces were used to determine attractiveness to insects and to examine subsequent colonization and growth patterns ...
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