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- - 2004
Preterm birth affects 12% of all births in the United States. Recent studies support the hypothesis that progesterone supplementation reduces preterm birth in a select group of women (ie, those with a prior spontaneous birth at <37 weeks of gestation). Despite the apparent benefits of progesterone in this high-risk population, ...
Bergmann Renate L - - 2004
The problem of preterm deliveries has worsened in developed countries over the past decade. To evaluate whether multiple deliveries had an impact on this development, we analyzed the data of the Berlin Perinatal Survey from 1993-1999 for 206,308 deliveries. The prevalence of preterm deliveries was fairly constant during this period, ...
Schultz C - - 2004
The inflammatory response plays a major role in the induction of several neonatal diseases. We hypothesize that an imbalance between the pro- and anti-inflammatory response is crucial for the previously shown enhanced production of proinflammatory cytokines in term and preterm infants during infection. To test this hypothesis, we compared the ...
Sosa C - - 2004
Bed rest in hospital or at home is widely recommended for the prevention of preterm birth. This advice is based on the observation that hard work and hard physical activity during pregnancy could be associated with preterm birth and with the idea that bed rest could reduce uterine activity. However, ...
Hunt R - - 2004
A potential therapeutic effect of sex steroids on premature infants has been proposed from animal data and observational studies in humans. Purported benefits include reduction in chronic lung disease, improved bone density and improved neurodevelopmental outcome. To determine if estrogens or progestins, either alone or in combination, when compared to ...
Paradisis M - - 2004
Inotropes are widely used in preterm infants to treat cardiovascular compromise, which may result from early adaptive problems of the transitional circulation, perinatal asphyxia or sepsis. Sustained hypotension and poor organ blood flow are associated with brain injury including peri/intraventricular haemorrhage and subsequent poor neurodevelopmental outcomes. Adrenaline (epinephrine) infusions are ...
Gaunekar N N - - 2004
Calcium channel blocker maintenance therapy is one of the types of tocolytic therapy used after an episode of threatened preterm labour (and usually an initial dose of tocolytic therapy) in an attempt to prevent the onset of further preterm contractions. To assess the effects of calcium channel blockers as maintenance ...
Yiallourides M - - 2004
The tibial speed of sound (SOS) was measured in 91 healthy singleton infants between 31 and 42 weeks of gestation and 12 sick preterm infants. In healthy infants, the tibial SOS was associated with corrected gestational age (r = 0.40, p < 0.001) but not birth weight. The median tibial ...
Bessler H - - 2004
IL-1 receptor antagonist (IL-1ra) gene polymorphism was examined in 95 Israeli preterm newborns and compared to that of adult volunteers. The genotype was determined using PCR amplification of the variable region of intron 2 of the IL-1ra gene. The IL-1raA1 allele was found to be predominant in the two groups. ...
Doggrell Sheila A - - 2003
Preterm delivery is the major determinant of infant mortality and there is a lack of treatments for this condition. Women presenting for prenatal care with a history of a spontaneous preterm delivery were assigned 17 alpha-progesterone caproate (17P) 250 mg/week i.m. between 16 and 20 weeks of gestation or placebo ...
Takaya Rieko - - 2003
Hand-mouth contacts (HMCs) and other spontaneous movements of five low-risk preterm infants were studied longitudinally after their birth until 60 weeks postmenstrual age. For all infants, HMCs that emerged in the preterm period could not be observed transiently after 45 weeks, however, they re-emerged after 50 weeks postmenstrual age. In ...
Petrou Stavros - - 2003
OBJECTIVES: To compare the cumulative use and cost of hospital inpatient services to 5 years of age by individuals divided into 4 subgroups by gestational age at birth. DESIGN: Costs applied to the hospital service utilization profile of each infant born in 2 areas covered by the Oxford Record Linkage ...
Owen John - - 2003
Across numerous investigations and study populations, the relationship between shortened cervical length and spontaneous preterm birth is consistent and compelling. However, one must recognize the imperfect test characteristics of cervical ultrasound for predicting prematurity, particularly in low-risk populations. It should be clear that this relationship supports interactions with the other ...
Belej-Rak Timea - - 2003
OBJECTIVE: The purpose of this study was to determine the effectiveness of cerclage for a shortened cervix on transvaginal ultrasound scanning in terms of the rates of preterm delivery and adverse neonatal and maternal outcomes. STUDY DESIGN: Pre-MEDLINE and MEDLINE, EMBASE, and the Cochrane Library were searched for human studies ...
Subhedar Nimish V - - 2003
Systemic hypotension is a common complication of preterm birth affecting approximately one-third of very low-birthweight infants. There is considerable variation between neonatal units in the reported prevalence of hypotension, the threshold for therapeutic intervention and the nature of any cardiovascular support offered. Systemic hypotension is associated with adverse long-term neurodevelopmental ...
Harding David - - 2003
OBJECTIVES: The angiotensin-converting enzyme (ACE) deletion (D) variant is associated with greater ACE activity and perhaps with deleterious cardiorespiratory pathophysiological responses. We determined whether the early health status of the preterm infant was adversely influenced by homozygosity for the D allele (DD genotype) compared with ID or II genotype. Study ...
Huddleston John F - - 2003
We are continually reminded that the preterm birth rate has failed to improve; in fact, it has increased over the last 20 years. Much of this increase is related to the tremendous strides made by neonatologists and the resulting increased willingness of obstetricians to deliver preterm babies from hostile intrauterine ...
Morrison John C - - 2003
A comprehensive evidence-based review of the clinical data leads to the conclusion that if patients at high risk for preterm birth (eg, prior preterm birth because of preterm labor, twins and higher-order multiple gestation, women who have preterm labor during the current pregnancy tocolyzed effectively) use the comprehensive system of ...
Cranefield David J - - 2004
BACKGROUND: The use of postnatal corticosteroids to treat or prevent chronic lung disease is common in very preterm infants. Medullary nephrocalcinosis has been noted as a possible side effect. OBJECTIVE: This prospective study was designed to assess the incidence of nephrocalcinosis in extremely preterm infants exposed to dexamethasone. PATIENTS AND ...
Thompson S W - - 2003
OBJECTIVE: The role of "novel substrates" in neonatal nutrition has generated much interest in recent years. Glutamine has been recognized as a "conditionally essential" amino acid in critically ill adults, particularly for gut and immune function; however, its potential role in the neonate remains unclear. The authors examined the safety ...
Bryan Elizabeth - - 2003
As the number of multiple births has steadily risen over the past 20 years, twins and triplets form an increasingly large proportion of the preterm population. This causes a number of stresses to their families. Addressing the cause of the epidemic of iatrogenic multiple births is the most effective way ...
- - 2003
Preterm birth affects 12% of all births in the United States. Recent studies support the hypothesis that progesterone supplementation reduces preterm birth in a select group of women (ie, those with a prior spontaneous birth at <37 weeks of gestation). Despite the apparent benefits of progesterone in this high-risk population, ...
Taddio Anna - - 2003
BACKGROUND: Sucrose is an effective analgesic for procedural pain in preterm infants. It has been hypothesized that its analgesic effects are mediated by the release of endogenous opioid neurotransmitters such as beta-endorphin. OBJECTIVE: To determine whether intraoral administration of sucrose was associated with an increase in serum beta-endorphin concentrations in ...
Medda Emanuela - - 2003
OBJECTIVE: To determine whether genetic amniocentesis performed in the second trimester of pregnancy is associated with the risk of preterm delivery. STUDY DESIGN: Case-control study performed in several departments of obstetrics and gynaecology of nine European countries. Three thousand and ninety-one preterm births and 5298 controls randomly selected from singleton ...
Rubinacci Alessandro - - 2003
OBJECTIVE: To evaluate the potential role of quantitative ultrasound (QUS) investigation in assessing the osteopenia of prematurity. DESIGN: QUS parameters measured at the time of discharge were related to the anthropometric characteristics and age (postnatal and gestational) of 51 (34 female and 17 male) preterm infants fed fortified human milk. ...
Elliott John P - - 2003
OBJECTIVE: To determine the neonatal and economic consequences of nonindicated preterm delivery in singleton gestations. STUDY DESIGN: From a database of women with high-risk pregnancies enrolled for outpatient nursing services between October 1995 and February 2000, singleton gestations with induced labor or scheduled cesarean delivery and a gestational age at ...
Leijon I - - 2003
OBJECTIVES: To assess the use of healthcare resources for preterm infants and to evaluate family function and socioeconomic support in a defined population from birth to 4 years of age. METHODS: In a prospective case-control study, 39 singleton preterm infants without prenatal abnormalities born during an 18 month period were ...
Marriott L D - - 2003
The greatly improved survival rate of infants born both preterm and low birth weight (LBW) has led to the subsequent growth and development of these infants becoming an important focus for research. Preterm infants begin life with, or acquire as a result of their prematurity, greater morbidity than term born ...
Cayabyab R G - - 2003
OBJECTIVE: To determine whether the presence of the proinflammatory cytokine interleukin (IL)-1beta in the lungs of preterm infants immediately after birth was associated with maternal inflammation and could predict adverse neonatal outcome. STUDY DESIGN: Prospective evaluation of serially obtained tracheal aspirates for the presence of IL-1beta in 25 preterm infants ...
Moore Mary Lou - - 2003
Preterm births in the United States reached a 20-year high of 11.9% in 2001. Preterm and low-birth-weight births are the end result of multiple pathways. This article examines two decades of multidisciplinary research related to preterm birth from both individual and ecologic perspectives. The difficulties in identifying women who will ...
Smith Gordon C S - - 2003
To determine whether a short interval between pregnancies is an independent risk factor for adverse obstetric outcome. Retrospective cohort study. Scotland. 89 143 women having second births in 1992-8 who conceived within five years of their first birth. Intrauterine growth restriction (birth weight less than the 5th centile for gestational ...
Begum F - - 2003
A Prospective case control study was conducted in a tertiary hospital in Northern India to determine the risk factors associated with preterm labour. Ninety four consecutive patients with preterm spontaneous labour were selected as cases and 188 patients with term spontaneous labour as control. The incidence of preterm labour was ...
Tekesin Ismail - - 2003
OBJECTIVE: This study was to evaluate the predictive value of the uterine cervix tissue with the use of quantitative ultrasound gray level analysis for preterm delivery. STUDY DESIGN: Sixty-eight patients with preterm labor between 20 and 35 weeks of gestation were included. When two-dimensional transvaginal ultrasound measurement of cervical length ...
Schwarz Matthias K - - 2003
Preterm labour is a major cause of perinatal mortality and morbidity. However, during the past 40 years of clinical studies and despite the use of multiple therapeutic agents, the rate of preterm birth has not drastically declined. In 1991, it was estimated that in the US approximately 116,000 women admitted ...
- - 2003
Preterm birth is the leading cause of neonatal mortality in the United States, and preterm labor precedes 40-50% of preterm births. Preterm birth accounts for 35% of all U.S. health care spending for infants and 10% of all such spending for children. Approximately 467,000 live births annually (11.5% of all ...
Saini Santosh - - 2003
The present study was conducted on 25 cases of preterm, premature rupture of membranes and 25 patients preterm with intact membranes, between 28-36 weeks of gestation, admitted in the maternity ward of Obstetrics and Gynecology, PGIMS, Rohtak. The sensitivity and specificity of CRP determination was found to be 80% each ...
Lurie Samuel - - 2003
OBJECTIVE: To evaluate the distribution of Lewis blood group phenotype and secretor status among women with preterm premature rupture of membranes. METHODS: ABO and Lewis blood group phenotypes were determined in 20 consecutive women with preterm premature rupture of membranes. The control group was composed of 48 women from our ...
Magriples U - - 2003
OBJECTIVE: To assess the relative risks and costs of delivery at 34 vs. 35 weeks with preterm premature rupture of membranes (PROM). STUDY DESIGN: Retrospective study of singleton gestations with preterm PROM over a 5-year period. Patients who delivered at 34 vs. 35 weeks were compared. RESULTS: Sixty-five patients were ...
Leung Tse N - - 2003
The benefits of a single course of antenatal corticosteroids on neonatal outcomes are well established. There is, however, much controversy about how long this treatment should continue, and whether repeated courses should be administered if the women remain at risk for preterm delivery 7 days after the initial therapy. This ...
Schwiertz Andreas - - 2003
The establishment and succession of bacterial communities in hospitalized preterm infants has not been extensively studied. Because earlier studies depended on classical cultural techniques, their results were limited. This study monitored the establishment and succession of the neonatal microbiota in the first weeks of life by analyzing the 16S rDNA ...
Skerman Jonathan H - - 2003
Preterm birth is a continuing obstetric problem that contributes significantly to the incidence of perinatal death and long-term handicap. In this context, various studies have shown preterm births account for between 69% and 83% of neonatal deaths. Despite this, the incidence of preterm birth has remained static for many years. ...
Owen John - - 2003
The National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network has completed 2 prospective, blinded observational studies of cervical ultrasound for the prediction of preterm birth and the identification of high-risk women who might benefit from interventions aimed at preventing spontaneous preterm birth. These reports and other ...
Maner William L - - 2003
OBJECTIVE: To determine whether delivery can be predicted using transabdominal uterine electromyography. METHODS: A total of 99 patients were grouped as either term (37 weeks or more) or preterm (less than 37 weeks). Uterine electrical activity was recorded for 30 minutes in clinic. Electromyographic "bursts" were evaluated to determine the ...
Mercuri Eugenio - - 2003
OBJECTIVES: The aim was to establish the range of neurologic findings in preterm infants reaching term age, their relation to gestational age at birth, and the possible differences with healthy term newborns tested during the first days of life. STUDY DESIGN: The Dubowitz neonatal neurologic examination was performed at term ...
Ruiz Roberta J - - 2003
Preterm birth rates continue to rise in the United States despite the advent of tocolytic agents and the identification of risk factors for preterm birth, such as vaginal infection and a shortened cervix. Although improvement in gestational-age-related survival of preterm infants has occurred as a result of the use of ...
Jacobsson Bo - - 2003
BACKGROUND: Previous studies have shown an association between intra-amniotic microbial invasion and/or inflammation and spontaneous preterm birth. The aim of this study was to investigate the occurrence of intra-amniotic microorganisms and cytokines [interleukin (IL)-6 and IL-8] in a Swedish population, with low incidence of preterm birth, of women with preterm ...
Ravetto P F - - 2003
BACKGROUND: Childhood leukaemias express novel, clonotypic fusion genes that may already be present at birth before the clinical manifestation of leukaemia. Exposure of the fetus to diagnostic x rays is reported to increase the risk of childhood leukaemia, and may do so by generating leukaemic fusion genes. Advances in neonatal ...
Herbst Andreas - - 2003
A 27-year-old primigravid woman with advanced preterm labour at 23 weeks and 5 days gestation received tocolytic therapy with a continuous infusion of the oxytocin antagonist, atosiban, during 154 h. The delivery was postponed for 12 days. The baby was discharged after 3 months of neonatal care and at 6 ...
Friese Klaus - - 2003
Although there are many maternal characteristics associated with preterm birth, the aetiology in most cases is poorly understood. Our research demonstrates that multiple risk factors, such as maternal age and especially infection, are associated with preterm birth. Bacterial vaginosis and intrauterine infection are now believed to be an important risk ...
Helmer Hanns - - 2003
The purpose of this retrospective study is to evaluate the effects of atosiban (Tractocile available in Austria since February 2000) for routine treatment of women with threatened preterm delivery. The advantage of this drug compared to other tocolytic agents is its specific action on reproductive tissues without the accompanying severe ...
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