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Bothun Erick D - - 2013
OBJECTIVE: To evaluate the characteristics of strabismus in infants who underwent cataract surgery with and without intraocular lens (IOL) implantation. DESIGN: Secondary outcome analysis in a prospective, randomized clinical trial. PARTICIPANTS: The Infant Aphakia Treatment Study is a randomized, multicenter (n = 12), clinical trial comparing treatment of aphakia with ...
O'Reilly Megan - - 2013
Preterm birth affects 8-10% of human pregnancies and is a major cause of long-term disability. Individuals who are born very preterm, especially if they develop bronchopulmonary dysplasia (BPD), have an increased risk of impaired lung function in infancy, childhood and adulthood, and an increased risk of respiratory illness. Our aim ...
Shen Chung-Min - - 2013
Background:While the immaturity of toll-like receptor 2 (TLR2) and toll-like receptor 4 (TLR4) at birth in preterm newborns is known, their development during the first few months of life remains unclear.Methods:Blood monocytes of preterm newborns (gestational age = 24-36 weeks) were obtained every two weeks when possible in order to ...
Ulrich Marianne - - 2013
AIM: To study health, well-being in daily life, educational level and socio-economic status in adulthood in moderately premature infants and the relationship to gender and socio-economic status at birth. METHODS: Prospective long-term follow-up study of a cohort of infants with a gestational age between 32 and 37 weeks and term ...
Azad Meghan B - - 2013
The gut microbiota is essential to human health throughout life, yet the acquisition and development of this microbial community during infancy remains poorly understood. Meanwhile, there is increasing concern over rising rates of cesarean delivery and insufficient exclusive breastfeeding of infants in developed countries. In this article, we characterize the ...
Mittal Manoj K - - 2013
Objective. To determine if a positive result on pneumography, diagnosis of gastroesophageal reflux disease (GERD), or nontreatment of those diagnosed with GERD with antireflux medications predicts an increased recurrence risk of apparent life-threatening event (ALTE) over the first 4 weeks of follow-up. Methods. Secondary analysis of a prospective, observational study ...
Roggero P - - 2013
Early life events play a key role in the development of adult diseases. Survival is promoted by the developmental adaptation to environment although advantage in the short term implies a long-term cost with regard to the development of adult morbidities. This is particularly true for the infant born prematurely as ...
Andres Aline - - 2013
OBJECTIVE: To characterize growth, fat mass (FM), fat-free mass (FFM), and bone mineral content (BMC) longitudinally in healthy infants fed breast milk (BM), cow's milk formula (CMF), or soy formula (SF) during the first year of life. STUDY DESIGN: Infants were assessed at age 3, 6, 9, and 12 months. ...
Hussain Sadaf - - 2013
Vesicles and pustules in the neonate can be due to common or life threatening conditions. Recognizing key clinical features and understanding when and how to workup the various different vesiculopustular eruptions that occur in the neonatal period is vital. A rapid diagnosis of an infectious cause of a neonatal vesiculopustular ...
Wilkinson Dominic - - 2013
Are there some newborn infants whose short- and long-term care costs are so great that treatment should not be provided and they should be allowed to die? Public discourse and academic debate about the ethics of newborn intensive care has often shied away from this question. There has been enough ...
Shelmidine Nichole - - 2013
This study examines mortality in the North American (N.A.) population of silvered leaf monkeys (Trachypithecus cristatus) maintained in Association of Zoos and Aquarium's zoos. Understanding the causes of death associated with mortality rates (MR) can highlight relative susceptibility to intrinsic/extrinsic factors and differences between age and sex classes. Overall, life ...
Barrett Eoin - - 2013
The composition of the microbiota associated with the human ileum and colon in the early weeks of life of two preterm infants was examined, with particular emphasis on the Lactobacillus and Bifidobacterium members. Culturing work showed that bifidobacteria and lactobacilli in the ileostomy changed over time, compared with the colostomy ...
Corchia Carlo - - 2013
OBJECTIVE: To assess the relationship between antenatal factors and cause-specific risk of death in a large area-based cohort of very preterm infants. STUDY DESIGN: The ACTION (Accesso alle Cure e Terapie Intensive Ostetriche e Neonatali) study recruited during an 18-month period all infants 22-31 weeks' gestational age admitted to neonatal ...
Houweling Leanne M A - - 2013
OBJECTIVE: To compare hospitalization and medication use during the first year of life in preterm-born and term-born infants. STUDY DESIGN: Data for this retrospective cohort study were obtained from the linked PHARMO-Netherlands Perinatal Registry cohort. From this linked birth cohort, preterm infants (<37 weeks) born between 2004 and 2007 were ...
Czinn Steven J - - 2013
Gastroesophageal reflux (GER) is defined as the involuntary retrograde passage of gastric contents into the esophagus with or without regurgitation or vomiting. It is a frequently experienced physiologic condition occurring several times a day, mostly postprandial and causes no symptoms. These infants are also called 'happy spitters'. GER disease (GERD) ...
McCormick Taylor - - 2013
The differential diagnosis for the infant presenting with an apparent life-threatening event (ALTE) is broad. Toxic ingestions are a relatively uncommon cause of an ALTE, although several over-the-counter, prescription, and illicit drugs have been implicated. We present 2 cases of ethanol intoxication in infants as a previously unreported cause of ...
Blomquist Gregory E - - 2013
The genetics of primate life histories are poorly understood, but quantitative genetic patterns in other mammals suggest phenotypic differences among individuals early in life can be strongly affected by interactions with mothers or other caretakers. I used generalized linear mixed model extensions of complex pedigree quantitative genetic techniques to explore ...
Barrett Eoin - - 2013
OBJECTIVE: To examine the composition of the evolving microbiota of preterm infants at weeks 2 and 4 of life. SETTINGS: The paediatric intensive care unit of the Cork University Maternity Hospital. METHODS: The microbial diversity of faecal samples from 10 preterm infants was determined using 16S rRNA amplicon pyrosequencing technology. ...
Embleton Nicholas D - - 2013
The developmental origins of health and disease is an emerging area of interest that amalgamates many areas of scientific studies and encompasses a wide range of diverse disciplines from epidemiology to molecular biology. Evidence has accumulated to show that early life experiences, both in utero and in infancy have long-term ...
Yajima Ichiro - - 2013
BACKGROUND: Patent ductus arteriosus is a life-threatening condition frequent in premature newborns but also present in some term infants. Current mouse models of this malformation generally lead to perinatal death, not reproducing the full phenotypic spectrum in humans, in whom genetic inheritance appears complex. The ductus arteriosus (DA), a temporary ...
Apicella Fabio - - 2013
From early infancy onwards, young children appear motivated to engage reciprocally with others and share psychological states during dyadic interactions. Although poor reciprocity is one of the defining features of autism spectrum disorders (ASDs), few studies have focused on the direct assessment of real-life reciprocal behavior; consequently, our knowledge of ...
O'Keefe Emma - - 2013
Data sourcesMedline and Embase electronic databases were searched.Study selectionPapers published between 1996 and 2011 were initially identified by one reviewer, with 10% being independently reviewed by a second reviewer having predefined inclusion and exclusion criteria.Data extraction and synthesisData abstraction was conducted independently and meta-analysis was not attempted because of the ...
Bahoura Balaka - - 2013
The transition from fetal to neonatal life during birth is difficult for all babies. We aim to analyze the demography, clinical presentation, causes, and outcome of neurologically distressed newborns. We reviewed a total of 615 newborns files admitted with life threatening condition. Amongst them, 453 had presented neurological distress syndrome. ...
Vlaardingerbroek Hester - - 2013
Functional outcome of preterm infants is highly related to the quality and quantity of nutrients provided during the first few weeks of life. New guidelines, as published by the ESPGHAN in 2010, have provided means to prevent undernutrition in the NICU. Especially proteins and amino acids seem to play a ...
Moles Laura - - 2013
The establishment and succession of bacterial communities in infants may have a profound impact in their health, but information about the composition of meconium microbiota and its evolution in hospitalized preterm infants is scarce. In this context, the objective of this work was to characterize the microbiota of meconium and ...
Assiri Asaad - - 2013
Five children with glucose-galactose malabsorption (GGM) are presented. Two infants from Saudi Arabia were first-degree relatives, the third infant was unrelated and the other two were of Yemeni and Syrian origin, respectively. All the infants had chronic diarrhoea and four had failed to thrive since early infancy. All had stools ...
Keehn Brandon - - 2013
Background: Autism spectrum disorder (ASD) has been called a "developmental disconnection syndrome," however the majority of the research examining connectivity in ASD has been conducted exclusively with older children and adults. Yet, prior ASD research suggests that perturbations in neurodevelopmental trajectories begin as early as the first year of life. ...
Hammami S - - 2013
Major histocompatibility complex class II expression deficiency is an autosomal recessive primary combined immunodeficiency. The prevalence of this deficiency is the highest in Mediterranean areas, especially North Africa. Early diagnosis is essential due to high mortality in the first 2 years of life. Prognosis is very poor when bone marrow ...
Ismail Abdul Qader Tahir - - 2013
A 7-week-old infant presented to hospital pale and floppy, with 5 s capillary refill time. Blood gas showed severe acidosis (pH 6.86, partial pressure of carbondioxide 10.55 kPa, base excess 21.1). Hypotension persisted despite several fluid boluses so she was intubated and started on inotropic support. A chest X-ray revealed ...
Tomori Zoltan - - 2013
Various diseases often result in decompensation requiring resuscitation. In infants moderate hypoxia evokes a compensatory augmented breath - sigh and more severe hypoxia results in a solitary gasp. Progressive asphyxia provokes gasping respiration saving the healthy infant - autoresuscitation by gasping. A neonate with sudden infant death syndrome, however, usually ...
Rogers Lynette K - - 2013
Soluble RAGE (sRAGE) has been associated with multiple inflammatory responses including maternal chorioamnionitis and preeclampsia. Analysis of umbilical cord blood levels have also indicated that sRAGE levels in the infant are affected by maternal inflammation. S100b is a ligand for RAGE and increases in circulating S100b levels are associated with ...
Jones Marcus H MH Institute of Biomedical Research, and School of Medicine, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, - - 2013
To explore the relationship between prematurity, gender and chorioamnionitis as determinants of early life lung function in premature infants. Placenta and membranes were collected from preterm deliveries (<37 weeks gestational age) and evaluated for histological chorioamnionitis (HCA). Patients were followed and lung function was performed in the first year of ...
Belnoue Elodie E World Health Organization Collaborating Center for Vaccinology and Neonatal Immunology, Departments of Pathology-Immunology and Pediatrics, University of Geneva, Geneva, - - 2013
INFANT MORTALITY FROM VIRAL INFECTION REMAINS A MAJOR GLOBAL HEALTH CONCERN: viruses causing acute infections in immunologically mature hosts often follow a more severe course in early life, with prolonged or persistent viral replication. Similarly, the WE strain of lymphocytic choriomeningitis virus (LCMV-WE) causes acute self-limiting infection in adult mice ...
Loccisano Anne E AE Center for Human Health Assessment, The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina, USA. - - 2013
Perfluoroalkyl acid carboxylates and sulfonates (PFAA) have many consumer and industrial applications. Developmental toxicity studies in animals have raised concern about potential reproductive/developmental effects of perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS); however, in humans conflicting results have been reported for associations between maternal PFAA levels and these outcomes. Risk ...
Hanna M H MH Department of Pediatrics, University of Kentucky, Lexington, KY, - - 2013
Necrotizing enterocolitis (NEC) is the most common gastrointestinal (GI) emergency that primarily affects premature infants. In the last decade, there have been significant advances to our understanding of neonatal NEC. The exact etiology of NEC remains unclear, but it is widely considered a multifactorial disease; prematurity, enteral feeding, intestinal hypoxia-ischemia, ...
Kushnerenko Elena V EV School of Psychology, Institute for Research in Child Development, University of East London London, - - 2013
Orienting to salient events in the environment is a first step in the development of attention in young infants. Electrophysiological studies have indicated that in newborns and young infants, sounds with widely distributed spectral energy, such as noise and various environmental sounds, as well as sounds widely deviating from their ...
O'Reilly Megan M Department of Pediatrics, Women and Children's Health Research Institute, Katz Group Centre for Pharmacy and Health Research, University of Alberta, Edmonton, AB, Canada T6G - - 2013
Bronchopulmonary dysplasia (BPD) is the chronic lung disease of prematurity that affects very preterm infants. Although advances in perinatal care have changed the course of lung injury and enabled the survival of infants born as early as 23-24 weeks of gestation, BPD still remains a common complication of extreme prematurity, ...
Hussamy Deana J DJ Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Parkland Health and Hospital System, 5323 Harry Hines Boulevard, Dallas, TX 75390-9032, - - 2013
Although uncommon during pregnancy, cirrhosis results in multiple medical complications impacting both mother and fetus. Previous reports suggest liver dysfunction in pregnancy causes accumulation of neurotoxins within the maternal compartment that increases neonatal morbidity through placental transfer. We present a case of a 36-year-old G2P1 female with history of biliary ...
Gray Brian W BW Department of Surgery, University of Michigan, Ann Arbor, MI, USA. - - 2013
An artificial placenta would change the paradigm of treating extremely premature infants. We hypothesized that using a veno-venous extracorporeal life support (VV-ECLS) artificial placenta after ventilatory failure would stabilize premature lambs and maintain normal fetal physiologic parameters for 70 h. A near-term neonatal lamb model (130 days; term=145) was used. ...
Cizmeci Mehmet Nevzat - - 2012
A neonatal tooth is defined as a tooth, which erupts within the first month of life. Herein, we report a premature infant with a neonatal tooth.
Black M Jane - - 2012
Preterm birth is defined as birth prior to 37 completed weeks of gestation and comprises 9.6% of total births worldwide(1) . Preterm birth can be further sub-classified into near term (birth at 34 - 37 weeks gestation), moderately preterm (birth between 32 and 33 weeks of gestation), very preterm (birth ...
Rao Raghavendra R Department of Pediatrics, Division of Neonatology, University of Minnesota, Mayo Mail Code 391, 420 Delaware Street, SE, Minneapolis, MN 55455, - - 2013
Iron deficiency anemia affects many pregnant women and young infants worldwide. The health impact is significant, given iron's known role in many body functions, including oxidative and lipid metabolism, protein synthesis and brain neurochemistry. The following research determined if (1)H NMR spectroscopy-based metabolomic analysis of cerebrospinal fluid (CSF) could detect ...
Delfosse N M NM University of Cincinnati College of Medicine, Cincinnati, OH, - - 2013
To determine acceptance of donor human milk (DM) for feeding preterm infants and whether offering DM, alters mothers' milk (MM) feeding. Infant feeding data were collected from medical records of 650 very preterm infants enrolled between 2006-2011 in two hospital level III neonatal intensive care units (NICUs) in Cincinnati, Ohio. ...
Olza Fernández Ibone - - 2012
INTRODUCTION: Maternal-infant separation (MIS) is a highly stressful situation for the neonate. MATERIALS AND METHODS: A study was conducted to observe and describe the reactions of term neonates to brief maternal separation and restoration of skin contact within the first 48h of life, and to assess whether the mode of ...
Wille David-Alexander - - 2012
Juvenile xanthogranuloma is a histiocytic proliferative disease that predominantly affects the skin. Extracutaneous involvement is rare. We present the case of a 6-month-old infant with acute paraplegia. Magnetic resonance imaging showed an intraspinal extradural mass at midthoracic level with marked compression of the spinal cord. Complete tumor removal was achieved ...
Savino F - - 2012
Aim: To investigate the role of ghrelin and obestatin in infancy. Methods: We measured ghrelin and obestatin concentrations in blood samples of infants, lactating mothers, and in breast milk. Results: The median (interquartile range) serum ghrelin concentrations were 922.11 (868.44) pg/ml in infants, 667.88 (942.78) pg/ml in lactating mothers, and ...
Komuro Hiroaki - - 2012
The authors report on 3 infants below 6 months of age at diagnosis, with cervicomediastinal neuroblastoma who presented with life-threatening tracheal obstruction as an oncologic emergency. These neuroblastomas were characterized by favorable biology and chemoresistance. All initially grew rapidly before spontaneously regressing. Nerve injuries occurred in all patients as a ...
Rumisha S F - - 2012
Lack of birth and death registries in most of developing countries, particularly those in sub-Saharan Africa led to the establishment of Demographic Surveillance Systems (DSS) sites which monitor large population cohorts within defined geographical areas. DSS collects longitudinal data on migration, births, deaths and their causes via verbal autopsies. DSS ...
Kandraju Hemasree - - 2012
Background: Preterm neonates with respiratory distress syndrome (RDS) benefit from early application of nasal continuous positive airway pressure (nCPAP). However, it is not clear whether surfactant should be administered early as a routine to all such infants or later in a selective manner. Objective: It was the aim of this ...
Blanco Cynthia L CL Department of Pediatrics, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA. - - 2013
Transient neonatal hyperglycemia (HG) has been reported in up to 80% of extremely preterm human infants. We hypothesize that severe HG is associated with increased morbidity and mortality in preterm baboons. Sixty-six baboons born at 67% of gestation were studied. HG was defined as serum glucose level ≥150 mg/dl during ...
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