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Results 51 - 100 of 989
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Srinivasjois Ravisha - - 2010
OBJECTIVE: To study the predictive abilities of laboratory parameters in the prediction of progression of definite necrotising enterocolitis (NEC) to need for surgery or death in preterm neonates. METHODS: Retrospective analysis of data (January 2001-July 2006) on all preterm (gestation < 32 weeks) neonates with definite (Stage > or = ...
Rees Clare M - - 2010
PURPOSE: There is scant epidemiological data on necrotizing enterocolitis (NEC), so we conducted a national study to characterize prevalence, surgical management, and mortality. METHODS: A prospective cross-sectional survey was performed in the United Kingdom requesting data from 158 level 2 and 3 neonatal intensive care units (NICUs) during 2 winter ...
Cetinkaya Merih - - 2010
The purpose of this study was to evaluate the efficacy of serial serum amyloid A (SAA) measurements in diagnosis and follow-up of necrotizing enterocolitis (NEC) in preterm infants. A total of 144 infants were enrolled in this observational study. The infants were classified into three groups: group 1 (infants with ...
Bagci S - - 2010
The clinical presentation of the viral enteric pathogens in newborn infants has not been adequately examined. The aim of this study was to evaluate the clinical characteristics of viral intestinal infections in newborn infants. Clinical data of all term and preterm infants admitted to our tertiary neonatal intensive care unit ...
Chaaban Hala - - 2010
To compare inter-alpha inhibitor protein (IaIp) levels in neonates with proven necrotizing enterocolitis (NEC) and neonates with other, nonspecific abdominal disorders. This was a prospective observational study of neonates in the neonatal intensive care unit. NEC was diagnosed according to Bell's staging criteria. The nNeonates in the control group had ...
Srinivasan P - - 2010
An uncommon clinical entity mimicking necrotizing enterocolitis (NEC) is allergic enterocolitis secondary to cow's milk protein allergy. Although milk protein allergy is the most common food allergy among infants and young children, the incidence and prevalence of this disease entity presenting as enterocolitis in neonates is not well documented. We ...
Thuijls Geertje - - 2010
OBJECTIVES: To improve diagnosis of necrotizing enterocolitis (NEC) by noninvasive markers representing gut wall integrity loss (I-FABP and claudin-3) and gut wall inflammation (calprotectin). Furthermore, the usefulness of I-FABP to predict NEC severity and to screen for NEC was evaluated. METHODS: Urinary I-FABP and claudin-3 concentrations and fecal calprotectin concentrations ...
Bulbul Ali - - 2010
OBJECTIVE: To evaluate the success rate of insertion of percutaneously inserted central catheters (PICCs) and their duration; and the short- and long-term complications in the neonatal period. STUDY DESIGN: We did a prospective collection and analysis of the data of all infants who underwent PICC placement from January 2005 and ...
Duro Debora - - 2010
To determine risk factors for intestinal failure (IF) in infants undergoing surgery for necrotizing enterocolitis (NEC). Infants were enrolled in a multicenter prospective cohort study. IF was defined as the requirement for parenteral nutrition for >or= 90 days. Logistic regression was used to identify predictors of IF. Among 473 patients ...
Tepas Joseph J JJ - - 2010
BACKGROUND: Seven clinical metrics of metabolic derangement (MD7) have improved the timing of surgical intervention in infants with necrotizing enterocolitis (NEC). We compared surgical NEC outcomes based on MD7 at our center (unit S) with a similar center (unit B) that based its intervention on abdominal radiograph. STUDY DESIGN: Premature ...
McBride Whitney J - - 2010
BACKGROUND/PURPOSE: The purpose of this study was to determine whether a correlation exists between the finding of complex ascites on ultrasound (US) and the presence of intestinal perforation or gangrene in neonates with complicated necrotizing enterocolitis (NEC). METHODS: Charts of neonates with NEC (n = 76) whose care involved consultations ...
Deshpande Girish - - 2010
Systematic reviews of randomized, controlled trials (RCTs) indicate lower mortality and necrotizing enterocolitis (NEC) and shorter time to full feeds after probiotic supplementation in preterm (<34 weeks' gestation) very low birth weight (VLBW; birth weight <1500 g) neonates. The objective of this study was to update our 2007 systematic review ...
Evennett Nicholas J - - 2010
PURPOSE: Urinary intestinal fatty acid-binding protein (i-FABP), a marker of intestinal mucosal cell damage, has recently been proposed as a clinically useful measure in the early detection of necrotizing enterocolitis (NEC). However, there are no data on urinary i-FABP in more advanced (Bell stage II /III) NEC. The aim of ...
Wolfe Desi M - - 2010
Peripherally inserted central catheter use has become widespread in the management of premature infants as a means to provide long-term intravenous therapy and nutritional support until enteral feedings can be established. Peripherally inserted central catheters are not without complications. This article describes the case of a premature infant with oliguria ...
Geffers Christine - - 2010
OBJECTIVE: To describe the relationship between the use of central and peripheral venous catheters and the risk of nosocomial, primary, laboratory-confirmed bloodstream infection (BSI) for neonates with a birth weight less than 1,500 g (very-low-birth-weight [VLBW] infants). METHODS: Cox proportional hazard regression analysis with time-dependent variable was used to determine ...
Mungnirandr Akkrapol - - 2010
BACKGROUND: Gastroschisis is the most common neonatal anterior abdominal wall defect. Since all neonatal infants with gastroschisis require total parenteral nutrition (TPN), the authors retrospectively review was to find correlation between duration of TPN and postoperative complications including necrotizing enterocolitis (NEC) and poor feeding in gastroschisis patients. The secondary objective ...
Khan Rizwan A - - 2010
We report a neonate with acute appendicitis who was mistakenly diagnosed and treated initially as neonatal necrotizing enterocolitis. The diagnostic dilemma of this rare and life-threatening condition in premature babies and newborns is underlined. Awareness of this rare condition and possible differential diagnosis in this age group is also discussed.
King Deborah S - - 2010
BACKGROUND: Neonates and infants with congenital and acquired cardiac disease often require placement of central venous lines for extended intravenous therapy. It may be advantageous to avoid the larger venous vessels of the head and neck and lower extremities in order to preserve these for future interventions and therapies. We ...
Morowitz Michael J - - 2010
Neonatal necrotizing enterocolitis (NEC) remains an important cause of morbidity and mortality among very low birth weight infants. It has long been suspected that intestinal microbes contribute to the pathogenesis of NEC, but the details of this relationship remain poorly understood. Recent advances in molecular biology and enteric microbiology have ...
Luoto R - - 2010
One of the five level III neonatal intensive care units (NICU) in Finland has used prophylactic Lactobacillus GG (LGG) for very-low-birth-weight (VLBW) infants since 1997. To examine retrospectively the incidence of necrotizing enterocolitis (NEC) in all five university hospital NICUs in Finland in relation to the use of LGG during ...
Harris S L - - 2010
A case of extensive deep venous thrombosis in a four a day old infant was presented. Unusually this patient was shown to be heterozygous for three thrombophilia genes; Factor V Leiden, prothrombin and antithrombin gene mutations, the latter being novel. There are no randomized controlled trials to guide management in ...
Abdullah Fizan - - 2010
Necrotizing enterocolitis (NEC) is the most common gastrointestinal emergency of the neonate. Previous information about this disease has largely been gathered from limited series. We analyzed 13 years of the National Inpatient Sample (NIS) and 3 years of the Kids' Inpatient Database (KID; 1997, 2000, 2003) to generate the most ...
Koivusalo Antti - - 2010
INTRODUCTION: Isolated intestinal perforation (IIP) and necrotizing enterocolitis (NEC) seem to be separate diseases, though their surgical treatment is similar. We compared the morbidity after surgery for IIP and NEC in preterm infants (birth weight <1500 g). PATIENTS AND METHODS: Isolated intestinal perforation was defined as intestinal perforation with associated ...
Tepas J J JJ - - 2010
PURPOSE: Seven metrics of metabolic derangement were evaluated as contributors to clinical decision support for operative intervention in infants with suspected necrotizing enterocolitis (NEC). METHODS: Records of infants with suspected NEC without radiologic evidence of free air were queried for presence of 7 components of metabolic derangement (CMD), consisting of ...
Dvorak Bohuslav - - 2010
Maternal milk is a complex fluid, with multifunctional roles within the developing gastrointestinal tract. Epidermal growth factor (EGF) and heparin-binding EGF-like growth factor (HB-EGF) are members of the family of EGF-related peptides. Biological actions of these growth factors are mediated via interaction with the EGF-receptor (EGF-R). In the early postnatal ...
Szajewska Hania - - 2010
Uncertainty exists regarding the efficacy and safety of using probiotics and prebiotics in preterm infants. To review the evidence on the effects of administering probiotics and/or prebiotics to preterm infants. MEDLINE and the Cochrane Library were searched in August 2008. A supplemental search was conducted in July 2009. Only systematic ...
Hall Nigel J - - 2010
OBJECTIVES: Necrotizing enterocolitis (NEC) with multiple organ dysfunction syndrome (MODS) carries significant morbidity and mortality. There is extensive experimental evidence to support investigation of therapeutic hypothermia in infants with these conditions. We aimed to establish the feasibility and safety of mild hypothermia in preterm neonates with NEC and MODS as ...
Groenendaal F - - 2010
AIM: In this study, we determined whether outcome of preterm neonates has improved over a period of 16 years. STUDY DESIGN: Inborn neonates with a gestational age of 25.0-29.9 weeks were included. Patients with severe congenital malformations were excluded. Mortality and morbidity (chronic lung disease; CLD, intraventricular haemorrhage: IVH grade ...
Pizzuti Alfredo - - 2010
Pericardial effusion and cardiac tamponade are rare but life-threatening complications of percutaneosuly inserted central line (PICL) use in extremely low birth weight (ELBW) neonates, with an incidence reported between 0.07% and 2% of PICLs placement. Timely diagnosis and pericardiocentesis has been proven to be life-saving. The patient was a 620 ...
Sneath Nicole - - 2010
BACKGROUND: Peripherally inserted central catheters (PICCs) are commonly used in NICUs. Although they have many benefits, they also have many potential complications. Confirming catheter tip position is essential to decreasing complications, but the best method to achieve confirmation is unclear. OBJECTIVES: Literature review for studies that address line position confirmation ...
Lai Hong-Shiee - - 2010
Acute intra-abdominal abnormalities requiring emergency laparotomy in extremely low-birth-weight (ELBW) infants may increase morbidity and mortality. Focal intestinal perforations (FIPs) not due to necrotizing enterocolitis (NEC) are increasingly recognized in ELBW infants. We present an ELBW preterm male infant (24 weeks' gestation) with FIP who underwent successful abdominal surgery when ...
Twomey Jean E - - 2010
This study reports on maternal functioning, infant developmental, and permanency outcomes for 52 families following maternal participation in a family treatment drug court (FTDC) for perinatal substance users. Although the majority of families experienced positive child welfare outcomes, over time, maternal functioning deteriorated and infant developmental concerns were identified. Even ...
Che Lianqiang - - 2010
IUGR and preterm birth are leading causes of neonatal morbidity. We tested the hypothesis that IUGR predisposes to gut maladaption and necrotizing enterocolitis (NEC) using preterm pigs as models for preterm infants. First, full-term normal birth weight (NW) and IUGR ( approximately 65% of NW) pigs were compared. IUGR reduced ...
Tian Runlan - - 2010
Necrotizingenterocolitis (NEC) is a major health concern for premature infants and its patho-genesis remains poorly understood. The current mouse NEC model has not well been characterized. In this study, we develop a simple mouse model of NEC and determine the role of several factors modulating human NEC (i.e., breast milk, ...
Mshvildadze Maka - - 2010
To use high throughput techniques to analyze intestinal microbial ecology in premature neonates, who are highly susceptible to perturbations of the luminal environment associated with necrotizing enterocolitis (NEC) and late-onset sepsis. With non-culture-based techniques, we evaluated intestinal microbiota shortly after birth and during hospitalization in 23 neonates born at 23 ...
Karagianni Paraskevi - - 2010
We studied the effect of early (< or = 5 days) versus delayed (> or = 6 days) initiation of minimal enteral feeding (MEF) on the incidence of necrotizing enterocolitis (NEC) and feeding intolerance in preterm infants with intrauterine growth restriction (IUGR) and abnormal antenatal Doppler results. We performed a ...
Soylu Hanifi - - 2010
OBJECTIVE: To evaluate the efficacy of local instillation of tissue plasminogen activator (tPA) for restoring function to occluded central venous catheters (CVCs) in the neonatal population. STUDY DESIGN: This was a retrospective review of patients admitted to the neonatal intensive care unit during September 2000 to April 2006 who received ...
Thomson Tricia L - - 2010
Pericardial effusion in neonates is a rare occurrence associated with malpositioning of central venous catheters. This report describes a case of pericardial effusion in which echocardiographic determination of line position, typically considered one of the most reliable means of placement verification, was misleading. The infant ultimately did well after pericardiocentesis, ...
Figueras-Aloy Josep - - 2010
OBJECTIVE: The objective of this study was to assess whether the use of high-dose intravenous immunoglobulin (IVIG) in late-preterm and term newborns with severe isoimmune hemolytic jaundice caused by Rh and ABO incompatibility was a risk factor for necrotizing enterocolitis (NEC). METHODS: An observational, retrospective study that encompassed 16 years ...
Lodha A - - 2010
OBJECTIVE: To investigate if circulating cytokines are related to growth and neurodevelopmental outcome following necrotizing enterocolitis (NEC). STUDY DESIGN: Pro-inflammatory cytokine levels were measured prospectively in 40 neonates and compared with neurodevelopmental outcome. Cytokine levels were measured at the onset of feeding intolerance (Group II, n = 17) or NEC ...
Liu Huili - - 2009
The aim of this study was to analyze the complication rates of peripherally inserted central catheters (PICCs) in neonatal intensive care units (NICUs) and to study the risk factors associated with the nonelective removal of PICCs. One hundred four premature infants were enrolled. Ninety-one PICCs were removed electively. The complications ...
Tsai Ming-Horng - - 2009
OBJECTIVE: To compare the complication rates of femoral versus nonfemoral sites of percutaneously inserted central venous catheters (PICCs) in very low birth weight infants. METHODS: Between 2004 and 2006, 518 PICCs inserted in 334 neonates with a birth body weight>or=1500 g were studied. 278 catheters were inserted at nonfemoral sites, ...
Garner Catherine E - - 2009
OBJECTIVE:: To determine differences in the profiles of volatile organic compounds (VOCs) in faecal samples from preterm infants who develop necrotising enterocolitis (NEC) compared with non-NEC controls. MATERIALS AND METHODS:: Daily faecal samples from preterm infants were collected prospectively during an 8-month period from a level 3 regional neonatal intensive ...
Trintis J - - 2010
OBJECTIVE: The objective of this study was to evaluate the safety and efficacy of early amino acid (early AA) administration in very low birth weight (VLBW) infants. STUDY DESIGN: A pre- and post-intervention study was conducted after initiating an early AA administration protocol. Clinical outcomes were collected for all VLBW ...
Varisco Brian Michael - - 2009
To report the first successful use of anidulafungin and liposomal amphotericin B in an infant with peritoneal candidiasis. An 11-day-old term female infant with Hirschsprung enterocolitis and bowel perforation was transferred to our institution on day 4 of hospitalization with septic shock and abdominal compartment syndrome. Initial peritoneal culture at ...
Garland J S - - 2009
The purpose of this pilot trial was to determine whether rates of contact dermatitis following cutaneous antisepsis for central catheter placement were similar among neonates treated with chlorhexidine gluconate and povidone-iodine. Chlorhexidine gluconate absorption was also evaluated. Infants weighing > or =1500 g and > or =7 days of age ...
Schnabl Kareena L - - 2009
OBJECTIVES: Necrotizing enterocolitis (NEC) has high morbidity in premature infants. Hypoxia-ischemia, infection, and enteral feeding are risk factors associated with NEC, whereas feeding human milk is protective. Vasoactive and inflammatory mediators in NEC remain elusive. Gangliosides are found in human milk and enterocyte membranes. An infant bowel model of NEC ...
Dizdar Evrim Alyamac EA Neonatal Intensive Care Unit, Zekai Tahir Burak Women Health and Education Hospital, Turkey. - - 2009
Enterocutaneous fistula in newborns and preterms is a well-recognized complication after necrotizing enterocolitis and abdominal surgical procedures/percutaneous interventions. However, to our knowledge, enterocutaneous fistula associated with purpura fulminans has not been reported before. Herein we report a preterm infant with purpura fulminans who developed cutaneous necrotic lesions on anterior abdominal ...
Mshvildadze Maka M Chachava Scientific-Research Institute of Perinatal Medicine Obstetrics and Gynecology, Tbilisi, - - 2009
Necrotizing enterocolitis (NEC) is a devastating disease affecting primarily premature infants. Despite advances in neonatal care, the mortality rate following NEC has not changed significantly in the past 30 years. New preventative measures are needed. In this review, we will provide information to assess the possible role of probiotics, prebiotics ...
Claud Erika C - - 2009
Neonatal necrotizing enterocolitis is a devastating inflammatory bowel disease of premature infants. The pathogenesis remains incompletely understood and there is no specific treatment. Efforts are ongoing to understand aspects of intestinal immaturity which contribute to susceptibility to this disease. This review focuses on bacterial colonization patterns, intestinal barrier function, and ...
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