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Colson Eve R - - 2009
To determine trends and factors associated with choice of infant sleeping position. Annual nationally representative telephone surveys from 1993 through 2007. Forty-eight contiguous states of the United States. Nighttime caregivers of infants born within the last 7 months; approximately 1000 interviews were given each year. Main Outcome Measure Whether infant ...
Mueni Eunice E KEMRI/Wellcome Trust Research Programme, Nairobi, - - 2009
Considerable uncertainty persists regarding the efficacy and safety of methylxanthines (caffeine, theophylline - in intravenous form named aminophylline) for the prevention and treatment of infant apnea. To help inform national guideline development in Kenya we undertook structured literature searches to identify current evidence on caffeine therapy for infant apnea. Available ...
Sarfi Monica - - 2009
BACKGROUND: Infants exposed to opioides in-utero frequently demonstrate withdrawal symptoms in the neonatal period and have difficulties with state regulation. AIM: This study examines sleep-wakefulness-distress patterns as indicators of regulatory mechanisms at 3 months of age. PARTICIPANTS: A national infant cohort (N=35) born to women in high-dose maintenance treatment during ...
Kamaluddeen Majeeda - - 2009
Apnea in a premature infant is not always due to immaturity and caffeine is not always the answer. We report a case of apnea in a preterm infant who presented at two weeks of life with increase in frequency of apnea that did not respond to caffeine. Family history was ...
Furlan V - - 2009
Therapeutic drug monitoring is critical to avoid overimmunosuppression or underimmunosuppression in young pediatric transplant recipients. The objective of this study was to examine cyclosporine (CsA) trough (C0) and 2-hour post-dose (C2) concentrations in the early period after liver transplantation (OLT) to determine whether CsA C2 monitoring is justified. Seventeen infants ...
Skouroliakou Maria - - 2009
AIM: To compare standard doses of theophylline and caffeine for apnea of prematurity in terms of apnea frequency and assess the need for therapeutic drug monitoring. METHODS: Seventy neonates less than 33 weeks gestation, breathing spontaneously, were randomly assigned (open-label) to receive either theophylline or caffeine for treatment or prevention ...
Joyner Brandi L - - 2009
OBJECTIVE: The goal was to evaluate pictures in magazines widely read by women of childbearing age, for adherence to American Academy of Pediatrics (AAP) guidelines for safe infant sleep practices. METHODS: Magazines were included in this study if they had an average female readership of >5 million, circulation of >900000, ...
Ralston Shawn - - 2009
OBJECTIVE: To determine the incidence of apnea in infants hospitalized with respiratory syncytial virus (RSV) bronchiolitis and identify relevant risk factors from the available literature. STUDY DESIGN: A systematic search of available databases for studies reporting the rate of apnea in a consecutive cohort of infants hospitalized with RSV infection ...
Ednick Mathew - - 2009
OBJECTIVE: To assess sleep-disordered breathing (SDB), sleep architecture, and arousal pattern in infants with achondroplasia and to evaluate the relationship between foramen magnum size and the severity of SDB. STUDY DESIGN: A retrospective review of polysomnographic recordings and medical records was performed in infants with achondroplasia and in aged-matched control ...
Bloch-Salisbury Elisabeth - - 2009
Breathing patterns in preterm infants consist of highly variable interbreath intervals (IBIs) that might originate from nonlinear properties of the respiratory oscillator and its input-output responses to peripheral and central signals. Here, we explore a property of nonlinear control, the potential for large improvement in the stability of breathing using ...
Thomas Karen A - - 2009
PURPOSE: The purpose of the study was to determine the number of days of diary data collection needed to reliably measure mother and infant sleep-wake pattern. STUDY DESIGN AND METHODS: Twenty healthy adult mothers and their healthy term gestation infants age 4 to 10 weeks postnatal participated in a single ...
Wheatley Eva - - 2009
To determine whether anti-reflux medications reduce bradycardia episodes attributed to clinically suspected gastroesophageal reflux (GER). We conducted a masked trial comparing metoclopramide, 0.2 mg/kg/dose q 6 hours, and ranitidine, 2 mg/kg/dose q 8 hours, with saline placebo. Each infant served as his own control. Preterm infants having >3 bradycardia episodes ...
Poets Anette - - 2009
Supine sleeping, recommended to prevent sudden infant death, should be started in the delivery hospital, but meets concern that neonates may exhibit more intermittent hypoxia in this position. We aimed to demonstrate that intermittent hypoxia is equally rare in supine and side position. We enrolled 609 term neonates in a ...
Bakewell-Sachs Susan - - 2009
OBJECTIVE: To describe the maturation of physiologic milestones in preterm infants born between 24 and 32 weeks' gestational age. METHODS: We abstracted daily physiologic maturity information on 865 infants born at < or =32 weeks' gestation in the Northern California Kaiser Permanente Medical Care Program between 1998 and 2001. Data ...
Silvestri Jean M - - 2009
Although there is a large body of literature describing infants who experience apnea of prematurity and apparent life-threatening events, there is no consensus regarding the use of home monitoring. This article focuses on issues that affect decision making regarding the use of home monitors in these two groups of infants ...
Slocum C - - 2009
A common clinical impression is that both gastroesophageal reflux (GER) and cardiorespiratory events increase after feeding in preterm infants. We aimed to measure objectively the effects of feeding on GER, apnea, bradycardia and desaturations. We conducted a retrospective review of premature infants with a gestational age of 23 to 37 ...
Fraiwan L - - 2009
A safe and wireless system for infant apnoea monitoring and treatment is proposed. It consists of two separate modules that detect apnoea based on a microcontroller processing and transmitting signals to the remote unit using wireless communication arrangement. Depending on the ECG signal, this system records the infant's heart and ...
Gauda Estelle B - - 2009
Peripheral arterial chemoreceptors, particularly the carotid body chemoreceptors, are the primary sites for the detection of hypoxia and reflexly increase ventilatory drive and behavioral arousal during hypoxic or asphyxial events. Newborn infants are at risk for hypoxic and asphyxial events during sleep, yet, the strength of the chemoreceptor responses is ...
Ochoa J - - 2009
Respiratory diseases are among the most important and serious conditions that can affect the newborn baby. A cessation of breathing, longer than 15 seconds, or accompanied by hypoxia or bradycardia, is called apnea of prematurity (AOP) and has been found in more than 50% of premature infants. An apnea detector ...
Qureshi M - - 2009
BACKGROUND: Although there is evidence that sighs are important to restore lung volume, the factors responsible for inducing a sigh and the effects of sighs on the stability of the respiratory system remain unclear. OBJECTIVE: To compare newborn with adult sigh morphology in order to better understand the physiological mechanisms ...
Altuve M - - 2009
This work presents an analysis of the information content of new features derived from the electrocardiogram (ECG) for the characterization of apnea-bradycardia events in preterm infants. Automatic beat detection and segmentation methods have been adapted to the ECG signals from preterm infants, through the application of two evolutionary algorithms. ECG ...
Marayong Panadda - - 2009
A portable design of a vibrotactile device for central apnea interruption in premature infants is developed. This small non-invasive device provides tactile stimulus on the infant's foot, stimulating the nervous system to help reinitiate breathing. The system consists of the vibrotactile device and a user interface which controls the activation ...
Ibeziako Ngozi S - - 2009
Objective. To determine infant sleeping position/place and the factors associated with them in South-eastern Nigeria. Methods. this is a cross-sectional study on infant sleeping environment. Subjects were the mother/ infant pairs that attended the well baby clinics at the Institute of Child Health of the University of Nigeria Teaching Hospital, ...
Whitley Julie Anne - - 2008
PURPOSE: To explore the hypothesis that nontouch therapy such as therapeutic touch (TT) reduces stress to a clinically important degree and is safe to use in preterm infants. DESIGN: A pilot randomized, double-blind, controlled trial. SUBJECTS: Two groups of 10 infants were enrolled and randomly assigned to treatment or nontreatment ...
Ho Ki-Hong Kevin - - 2008
OBJECTIVES: As laser surgery advances are made in the treatment of adult disorders, lasers are likewise increasingly being used in the treatment of pediatric otolaryngologic disorders. We evaluated outcomes of laser surgery in a group of infants and children with congenital and acquired airway disorders. MATERIALS AND METHODS: The medical ...
Charles Bruce G - - 2008
The objective of this study was to develop a population model of the pharmacokinetics (PK) of caffeine after orogastric or intravenous administration to extremely premature neonates with apnea of prematurity who were to undergo extubation from ventilation. Infants of gestational age <30 weeks were randomly allocated to receive maintenance caffeine ...
Brown Karen A - - 2008
PURPOSE: Although respiratory inductive plethysmography (RIP) is the method of choice for the assessment of sleep disordered breathing, it has not been applied to the study of infants at risk for postoperative apnea (POA). The purpose of this study was to apply RIP to evaluate breathing in these infants. An ...
Omari Taher I - - 2009
OBJECTIVE: To characterize esophageal motility during episodes of prolonged apnea in premature infants. STUDY DESIGN: We retrospectively reviewed combined manometric and physiological monitoring studies performed in tube-fed premature infants from 1994 to 2002. Apnea was defined as a respiratory pause of >20 seconds. For each apneic event, pharyngeal swallowing, esophageal ...
Al-Kindy Hussein A - - 2009
OBJECTIVE: To determine whether known risk factors for cardiorespiratory illnesses will help identify infants who could experience extreme events during an admission for an apparent life-threatening event (ALTE) or later at home. STUDY DESIGN: Retrospective cohort study of all patients admitted for ALTE between 1996 and 2006. Extreme events included ...
Abu-Shaweesh Jalal M - - 2008
Apnea of prematurity (AOP) remains a major clinical problem in present day neonatology that warrants frequent evaluations and imposes challenges in therapeutic strategies. Although the pathogenesis of AOP is poorly understood, it is probably a manifestation of physiologic immaturity of breathing control rather than a pathologic disorder. Immature breathing responses ...
Benavides F G - - 2009
OBJECTIVE: In Spain, sick pay benefits for work-related sick leave episodes are higher than for non-work-related episodes. Our aim is to assess whether time to return to work is longer for higher paid sick leave episodes than for lower paid episodes. METHODS: We used data from 62,376 work-related and 76,932 ...
Corvaglia L - - 2009
OBJECTIVE: To document the existence of a relationship between apnoea of prematurity (AOP) and gastro-oesophageal reflux (GER) in preterm infants. SETTING: Neonatal intensive care unit. PATIENTS: Twenty-six preterm infants (gestational age < or =32 weeks) with recurrent apnoeas. INTERVENTION: Simultaneous and synchronised recording of polysomnography and pH-impedance monitoring (pH-MII). Polysomnography ...
te Pas Arjan B - - 2008
There are no data describing how very preterm infants breathe spontaneously immediately after birth. We studied a convenience sample of spontaneously breathing infants <or=32 wk' gestation treated with facemask continuous positive airway pressure at birth. Airway pressure and flow were measured and each breath analyzed. Twelve infants had 792 breaths ...
Sung Melissa - - 2009
BACKGROUND: Actigraphy has been widely used in adults and children for the determination of sleep and wake. However, there have been limited studies in infants and to date there have been no studies to validate the reliability of actigraphy in preterm infants. AIM: To evaluate the usefulness of actigraphy in ...
Zotter Heinz - - 2009
AIM: To find out whether a correlation of heart rate (HR) and respiratory frequency (RF) defined as HR-RF-ratio (HRR) may be helpful to identify arousals in term and preterm infants. METHODS: Polygraphic recordings were performed in 25 term infants (gestational age 40.1 +/- 1.1 weeks) and 25 preterm infants (gestational ...
Carmichael Gordon A - - 2008
Estimates of Thai crude birth and death rates date from 1920 when the former was around 20 per thousand higher than the latter, implying natural increase of 2 percent per annum. Such disequilibrium cannot have been the norm over the long term historical past, when population growth must have been ...
Al-Saif Saif - - 2008
OBJECTIVE: To determine whether inhalation of 0.8% CO(2) in preterm infants decreases the duration and rate of apnea as effectively as or better than theophylline with fewer adverse side effects. STUDY DESIGN: A prospective, randomized, control study of 42 preterm infants of gestational age 27 to 32 weeks assigned to ...
Homma Ikuo - - 2008
Respiration is primarily regulated for metabolic and homeostatic purposes in the brainstem. However, breathing can also change in response to changes in emotions, such as sadness, happiness, anxiety or fear. Final respiratory output is influenced by a complex interaction between the brainstem and higher centres, including the limbic system and ...
Enders J - - 2008
BACKGROUND: CPAP is widely used in preterm infants on NICUs but it poses a stressful stimulus to the patient, sometimes requiring the use of analgosedative drugs. AIM: The aim of this study is to evaluate the risks and benefits associated with the use of low-dose morphine in preterm infants with ...
Cooper Peter A PA Department of Paediatrics, University of the Witwatersrand, South - - 2008
This study compared the characteristics of infants hospitalized with apnea that participated in a vaccine trial compared with two control groups which consisted of 100 infants randomly selected from the same vaccine trial and 52 consecutively born very low birth weight (VLBW) infants. A total of 23 infants were admitted ...
Foo J Y A - - 2008
The main objective of this study was to assess the capability of pulse transit time (PTT) to identify obstructive and/or central apnoeas from normal breathing patterns in sleeping infants. Clinical trials were conducted with PTT being monitored as an adjunct measure in routine overnight polysomnography (PSG) studies. Standard PSG scorings ...
Carbone Tracy - - 2008
OBJECTIVE: The American Academy of Pediatrics recommends immunization of preterm infants at 2 months' chronological age with diphtheria-tetanus-acellular pertussis vaccine, regardless of birth weight and gestational age. Several investigators have reported an increased incidence of cardiorespiratory events in preterm infants after immunization. Consequently, many primary care providers do not adhere ...
Murphy James J - - 2008
BACKGROUND: Postoperative apneas are reported in up to 49% of premature infants undergoing anesthesia for inguinal hernia repair. Our current practice is to monitor all of these babies in the intensive care unit (ICU) overnight after surgery. In addition to the considerable expense to the health care system, these cases ...
Klein Nicola P - - 2008
OBJECTIVES: Among hospitalized NICU infants, preimmunization apnea is a well-recognized predictor of postimmunization apnea. However, predictors for postimmunization apnea among NICU infants without preimmunization apnea have not been investigated. METHODS: Using a large NICU database in the Northern California Kaiser Permanente Medical Care Program, we abstracted NICU charts of infants ...
Hofstetter A O - - 2008
OBJECTIVE: Apnoea, bradycardia and hypoxemia occur frequently in extremely preterm infants, yet there is little longitudinal data describing cardiorespiratory development in these infants. This prospective study characterized early age-dependent changes in cardiorespiratory function and determined how activity is affected by factors such as underlying disease, postnatal insults and therapeutic interventions. ...
Courtney Rosalba - - 2008
OBJECTIVES: Konstantin Buteyko, M.D., Ph.D., claimed that breath holding time (BHT) can be used to detect chronic hyperventilation and that BHT predicts alveolar CO(2) (Pa(CO(2))) according to his patented mathematical formula. The Buteyko Breathing Technique (BBT) is believed to correct chronic hyperventilation as evidenced by increased BHT. In this study, ...
Reher C - - 2008
BACKGROUND: Apnoea of prematurity has been shown to respond to changes in posture. OBJECTIVE: To investigate the effect of three postural interventions on the rate of bradycardia and desaturation events. METHODS: 18 infants (< or =32 weeks' gestational age; 11 boys) with apnoea of prematurity underwent recordings of breathing movements, ...
Jauernig J - - 2008
The treatment of infants and small children with nebuliser-based therapy is commonplace. However, the breathing pattern proposed for general chapter 2.9.44 covering preparations for nebulisation, in development for the European Pharmacopoeia, is that of an adult at rest. This position paper is a concise summary of recommendations for 3 breathing ...
Noah J Adam - - 2008
Breathing frequency increases at the onset of movement in a wide rage of mammals including adult humans. Moreover, the magnitude of increase in the rate of breathing appears related to the rate of the rhythmic movement. We determined whether human infants show the same type of response when supported to ...
Hunt Carl E - - 2008
In 1,079 infants monitored for >700,000 hr at home for apnea or bradycardia, we found an association between infants having multiple events exceeding conventional or a priori defined more extreme thresholds and less favorable developmental outcome at 1 year of age than infants with few or no events. If it ...
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