Search Results
Results 1 - 50 of 915
1 2 3 4 5 6 7 8 9 10 >
Gostelow Martyn M Duke Clinical Research Institute, Duke University Medical Center, Durham, NC, - - 2014
Methicillin-resistant Staphylococcus aureus (MRSA) remains a significant cause of morbidity in hospitalized infants. Over the past 15 years, several drugs have been approved for the treatment of S. aureus infections in adults (linezolid, quinupristin/dalfopristin, daptomycin, telavancin, tigecycline and ceftaroline). The use of the majority of these drugs has extended into ...
Goralski Jennifer L JL Cystic Fibrosis Research and Treatment Center, The University of North Carolina at Chapel Hill - Medicine, UNC CF Center, CB #7248 101 Manning Drive, Chapel Hill, NC 27599, - - 2014
Airway dehydration in cystic fibrosis (CF) leads to chronic inflammation, ongoing infection and progressive lung disease. Restoration of airway hydration by inhalation of an osmotic agent (hypertonic saline) has been shown to be safe, effective and well-tolerated in adults with CF. Although the safety of hypertonic saline in infants and ...
Rauf Zubair Z Departments of *Obstetrics and Gynecology †Women's and Children's Health, University Department, Liverpool Women's Hospital, Institute of Translational Medicine, University of Liverpool, Liverpool, - - 2014
Assessing the feasibility, acceptability and safety of outpatient labour induction. MEDLINE database was searched for "outpatient labor induction" from January 1, 1986 to February 28, 2013. Main outcomes of interest included hyperstimulation, cesarean births, Apgar scores <7 at 5 minutes, arterial-cord pH of <7.10, and neonatal morbidity/mortality. Overall cesarean rates ...
Kreft Martina - - 2014
Abstract Aim: To compare the efficacy and safety of two misoprostol dosing regimens for induction of labour in primiparous (1P) and multiparous (>1P) women. Methods: Retrospective study of induction of labour using vaginal misoprostol 25 μg vs. 50 μg every 6 h in 942 women at a tertiary centre. The ...
Samiee-Zafarghandy Samira S 1Division of Pediatric Clinical Pharmacology, Children's National Medical Center, George Washington University School of Medicine and Health Sciences, Washington, DC. 2Duke Clinical Research Institute, Durham, NC. 3Department of Pediatrics, Duke University, Durham, NC. 4Department of Pediatrics, Children's National Medical Center, George Washington University School of Medicine and Health Sciences, Washington, DC. 5Department of Pharmacology and Physiology, Children's National Medical Center, George Washington University School of Medicine and Health Sciences, Washington, DC. 6Intensive Care, Erasmus Medical Center-Sophia Children's Hospital, Rotterdam, The Netherlands. 7Department of Paediatric Pharmacology, University Children's Hospital Basel, - - 2014
In view of the recent U.S. Food and Drug Administration's warning against the use of sildenafil in pediatric patients, we aimed to provide an updated overview of the dosing and safety of sildenafil in infants and to explore the relevance of the present safety concerns to the infant population. The ...
Kessel Irena I Department of Neonatology, Rappaport School of Medicine, Technion - Israel Institute of Technology, - - 2014
Abstract Paracetamol was reported to be effective for PDA closure. We present a case series of PDA closure by paracetamol in 7 premature infants. During the treatment, paracetamol blood levels did not exceed the recommended levels for analgesia and hyperthermia in 6 tested infants. None of the patients demonstrated significant ...
van den Nieuwboer M M Athena Institute, VU University Amsterdam, De Boelelaan 1085, 1081 HV Amsterdam, the Netherlands Swammerdam Institute for Life Sciences, University of Amsterdam, Kruislaan 318, 1098 SM Amsterdam, the - - 2014
In this study, we systematically evaluated safety aspects in clinical trials with probiotics and synbiotics in young infants (0-2 years of age). This study is an update of earlier reports and covers the recent literature from 2008-2013. The safety evaluation is performed along the Common Terminology Clinical Adverse Events (CTCAE) ...
Vandenplas Yvan Y *UZ Brussel, Vrije Universiteit Brussel, Brussels, Belgium †Division of Neonatology, Department of Pediatrics, Georgia Regents University, Augusta, USA ‡Schneider Children's Medical Center of Israel, Sackler Faculty of Medicine, Tel-Aviv University, Israel §Department of pediatrics, IRCCS Ospedale Maggiore Policlinico, DISCCO, University of Milan, Italy ||Department of Pediatrics, Jeanne de Flandre Lille University Children's Hospital, Faculty of Medicine, University of Lille 2, France ¶Department of Translation Medical Science, Section of Pediatrics, University of Naples, Federico II, Italy #Department of Pediatrics, The Medical University of Warsaw; - - 2014
AIM:: The aim of this review is to provide recommendations on the use of hydrolysates in infants when formula feeding is initiated. We performed an overview of reviews followed by a systematic review of subsequently published trials. We did find eight systematic reviews; only one study of limited quality was ...
Bamber Andrew R AR Department of Histopathology, Camelia Botnar Laboratories, Great Ormond Street Hospital for Children NHS Trust, Great Ormond Street, London, WC1N 3JH, UK, - - 2014
The purpose of this study was to investigate the frequency, circumstances, demographics, and causes of death of infants dying while seated in car safety seats. A retrospective review of a pediatric autopsy database at a specialist center over a 16-year period was undertaken to identify any infant deaths (aged <1 year), ...
Repa A A Department of Pediatrics and Adolescent Medicine, Division of Neonatology, Pediatric Intensive Care and Neuropediatrics, Medical University Vienna, - - 2014
Blood transfusions are required by most extremely low birth weight (ELBW) infants, but sometimes an adequate peripheral venous access cannot be achieved. Under these circumstances, we used 27 Gauge (G) peripherally inserted central catheter (PICC) lines that are routinely inserted on the second day of life. Due to their narrow ...
Kent George G Department of Political Science, University of Hawai'i, Honolulu, HI 96822, USA. - - 2014
Fatty acids in breast-milk such as docosahexaenoic acid and arachidonic acid, commonly known as DHA and ARA, contribute to the healthy development of children in various ways. However, the manufactured versions that are added to infant formula might not have the same health benefits as those in breast-milk. There is ...
Tonkin S L SL Department of Physiology, University of Auckland, Auckland, New - - 2013
Background Preterm infants are at risk of narrowing of the upper airway while restrained in infant car seats, leading to secondary apnea. However, some infants are able to maintain a normal airway. We hypothesized that this might reflect relatively smaller tongue size. Methods We retrospectively analyzed previously reported respiration-timed lateral radiographs of ...
Koklu Esad - - 2013
Neonatal seizures are often refractory to treatment with initial antiseizure medications. Clinicians turn to agents such as levetiracetam despite the paucity of published data regarding its safety, tolerability, or efficacy in the neonatal population. We describe a neonate who developed anaphylactic shock developing after receiving intravenous levetiracetam. This is the ...
Erlich Nicole - - 2013
Adult humans demonstrate differential processing of stimuli that were recurrent threats to safety and survival throughout evolutionary history. Recent studies suggest that differential processing of evolutionarily ancient threats occurs in human infants, leading to the proposal of an inborn mechanism for rapid identification of, and response to, evolutionary fear-relevant stimuli. ...
O'Neil Joseph - - 2013
Between 2007 and 2012 there have been several recommendations that infants and toddlers ride in a car safety seat (CSS) rear facing until 3 years of age. This study reports the effect of these recommendations on the observed direction of travel for infants and toddlers transported in motor vehicles between ...
Hernik A - - 2013
Milk secretion being an important way of elimination of organochlorine pesticides (OCPs) poses a concern due to potential risk for breastfed infants. This study aims to provide a tool for assessing such risks to infants exposed to OCPs (through accumulation in the mother's body), using calculated individual margins of safety ...
Tsai I-Jung - - 2013
Intermittent hemodialysis (IHD) is the most efficient form of renal replacement therapy (RRT) for removing toxic substances from patients' bodies. However, the efficacy and safety of IHD in infants and young children with inborn errors of metabolism are still not clear. This retrospective study included patients with urea cycle disorders, ...
Phelps Dale L - - 2013
Background:Myo-inositol given to preterm infants with respiratory distress has reduced death, increased survival without bronchopulmonary dysplasia, and reduced severe retinopathy of prematurity in two randomized trials. Pharmacokinetic (PK) studies in extremely preterm infants are needed before efficacy trials.Methods:Infants born in 23-29 wk of gestation were randomized to a single intravenous (i.v.) ...
Hill James - - 2013
Patent foramen ovale (PFO) is a known risk factor for paradoxical embolus, especially in the presence of other risk factors such as hypercoagulable states or central lines. A PFO is a common incidental finding in infants and children. However, paradoxical emboli are not common in infants, and so PFO closure ...
Lu Chun-Yi - - 2013
This Phase-IV study evaluated the human rotavirus (RV) vaccine Rotarix (RIX4414) to provide additional local clinical data to the Taiwan Food and Drug Association (NCT01198769). Healthy infants aged 6-12 weeks who were given a hepatitis B immunoglobulin (HBIg) dose after birth, received two doses of RIX4414 (0, 2-month schedule). Anti-RV ...
McCarthy Lisa K - - 2013
BACKGROUND AND OBJECTIVE:Hypothermia on admission to the NICU is associated with increased mortality in preterm infants. Many newborns are hypothermic on admission despite using polyethylene bags (PBs). Using exothermic mattresses (EMs) in addition to PBs may reduce hypothermia but increase hyperthermia. We wished to determine whether placing preterm newborns in ...
Parker Margaret G K - - 2013
Background:Pasteurized human donor milk (DM) is recommended by the World Health Organization and American Academy of Pediatrics for preterm infants when mother's own milk is unavailable, yet the extent and predictors of use and criteria for use in US neonatal intensive care units (NICUs) are unknown.Objective:This study aimed to evaluate ...
Newell Marie-Louise - - 2013
PURPOSE OF REVIEW: The introduction of combination ART to prevent mother-to-child-transmission (MTCT) has substantially decreased MTCT rates. However, there are concerns regarding safety of ART exposure for the mother, pregnancy outcome and infant. Changing MTCT prevention guidelines, with expanded eligibility, have led to a rapid increase of ART-treated women and ...
Srinivasjois Ravisha - - 2013
Regular administration of prebiotic oligosaccharides promote beneficial gut flora in infants. We aimed to systematically review randomized controlled trials evaluating the safety and efficacy of prebiotic oligosaccharide supplementation in preterm infants ≤37 weeks of gestation. Available studies from Medline, Embase, comparing formula milk supplemented with or without prebiotics, reporting on ...
Karadag-Oncel Eda - - 2013
Influenza is a cause of significant morbidity and mortality in young children. It is associated with high annual attack rates as well as being responsible for frequent outpatient visits and hospitalisations. Children aged <2 years are at the highest risk for serious illness or death during the influenza season. The ...
Togashi Takehiro - - 2013
BACKGROUND:: A 13-valent pneumococcal conjugate vaccine (PCV13) containing 6 additional serotypes not included in the 7-valent pneumococcal conjugate vaccine (PCV7) has been developed to broaden protection against Streptococcus pneumoniae, which is responsible for over 500,000 deaths annuallyworldwide in children <5 years of age. This study in Japanese infants evaluated the ...
Landers Susan - - 2013
Donor human milk has emerged as the preferred substrate to feed extremely preterm infants, when mother's own milk is unavailable. This article summarizes the clinical data demonstrating the safety, efficacy, and cost-effectiveness of feeding donor human milk to premature babies. It describes the current state of milk banking in North ...
Watt Kevin K Duke University, Pediatrics, Duke Clinical Research Institute, P.O. Box 17969, Durham, NC 27715, USA. - - 2013
Invasive fungal infections in infants admitted to the neonatal intensive care unit are common and often fatal. The mainstay of therapy against invasive fungal infections is antifungal agents. Over the last two decades, the development and approval of these drugs evolved tremendously, and the azole class emerged as important agents ...
Davis Natalie Louise NL Boston Children's Hospital Division of Newborn Medicine, Boston, MA 02115, USA. - - 2013
The American Academy of Pediatrics (AAP) recommends that all preterm neonates undergo a period of observation in a car safety seat before discharge, known as the Infant Car Seat Challenge (ICSC), to monitor for respiratory immaturity and the risk of adverse cardiopulmonary events in the upright position. However, no universal ...
Sirois Patricia A - - 2013
BACKGROUND:: This study evaluated effects of perinatal exposure to antiretroviral (ARV) medications on neurodevelopment of HIV-exposed, uninfected infants. METHODS:: HIV-exposed, uninfected infants (age 9-15 months) enrolled in SMARTT, a multisite prospective surveillance study, completed the Bayley Scales of Infant and Toddler Development-Third Edition (Bayley-III), assessing cognition, language, motor skills, social-emotional ...
Tagare Amit - - 2013
Bubble continuous positive airway pressure (BCPAP) is a low cost nasal CPAP delivery system with potential benefits to developing nations.Objective: To compare the efficacy and safety of BCPAP with ventilator-derived CPAP (VCPAP) in preterm neonates with respiratory distress.Methods: In a randomized controlled trial, preterm neonates with Silverman-Anderson score ≥4 and ...
Daetwyler K - - 2013
Therapeutic hypothermia has become a standard neuroprotective treatment in term newborn infants following perinatal asphyxia. Active cooling with whole body surface or head cooling is complex, expensive and often associated with initial hypothermic overshoot. We speculated that passive cooling might suffice to induce and maintain hypothermia. We analysed 18 asphyxiated ...
van Beelen Mirjam E J - - 2013
BACKGROUND: Unintentional falls and poisonings are major causes of death and disability among infants. Although guidelines are available to prevent these injuries, safety behaviours are not performed by parents, causing unnecessary risks. Little is known about safety behaviours of first-time parents and whether they behave according to these guidelines. AIMSOBJECTIVESPURPOSE: ...
Pauliah Shreela S - - 2013
Although selective or whole body cooling combined with optimal intensive care improves outcomes following neonatal encephalopathy in high-income countries, the safety and efficacy of cooling in low-and middle-income countries is not known. We performed a systematic review and meta-analysis of all published randomised or quasi-randomised controlled trials of cooling therapy ...
Veltman Larry - - 2013
Underwater birthing has become a popular birth practice in some areas of the country. Although many of these deliveries occur in a home birth setting, the practice has also been implemented in hospitals and birthing centers. There is continued controversy about the risks and benefits of underwater birthing (as opposed ...
Kelly Lauren E - - 2013
Neonates are commonly exposed to maternal codeine through breast milk. Central Nervous System (CNS) depression has been reported in up to 24% of nurslings following codeine exposure. In 2009, we developed guidelines to improve the safety of codeine use during breastfeeding based on previously established pharmacogenetic and clinical risk factors. ...
Alfaleh K - - 2013
Probiotics are live microbial feed supplements that beneficially affect the recipient by improving intestinal balance. In an updated systematic review, nineteen trials randomizing more than 2800 infants were included. In a meta-analysis of trial data, enteral probiotic supplementation significantly reduced the incidence of severe necrotizing enterocolitis (typical RR 0.35, 95% ...
Lokeshwar M R MR Department of Paediatrics, Kashyap Nursing Home, Mumbai Pediatrics, Imperial Mahal, Mumbai, Maharashtra India. - - 2013
To evaluate the immunogenicity and safety of a pentavalent rotavirus vaccine (PRV) in Indian infants. Open-label, single-arm multicentric study. Hospital facilities (out patients): One hundred and ten (110) healthy Indian infants were enrolled between the ages of 6 weeks and 12 weeks. Intervention: Three doses of oral pentavalent rotavirus vaccine ...
- - 2013
Intrapartum complications are responsible for approximately half of all maternal deaths, and two million stillbirth and neonatal deaths per year. Prolonged second stage of labour is associated with potentially fatal maternal complications such as haemorrhage and infection and it is a major cause of stillbirth and newborn morbidity and mortality. ...
Ojha Shalini - - 2012
AIM: Heated humidified high-flow nasal cannula oxygen (HHHFNC) is a relatively new form of respiratory support and is increasing in popularity despite lack of supportive evidence and amid safety concerns. We investigated the prevalence of its use in tertiary neonatal units in the UK. METHOD: Electronic survey. RESULTS: 57 units ...
Shad Roona - - 2012
Safety pins are not commonly aspirated objects in infants and form only a small fraction of all the metallic foreign body (FB) which accounts for 4.4% of all foreign bodies found in tracheobronchial tree. Bronchoscopy procedure has various complications, in addition to failure to remove FB due to its impaction, ...
Struijs Marie-Chantal - - 2012
BACKGROUND & AIMS: Efforts are directed at reaching the optimal composition of pediatric amino acids (AA) infusions. The goal was to demonstrate the safety and efficacy of a newly developed parenteral AA solution containing alanyl-glutamine (GLN-AA) compared to Standard-AA. METHODS: This is a randomized (2:1), double-blind, multicentre clinical pilot trial. ...
Mosca F - - 2012
Respiratory failure in the premature infants remains a difficult challenge. An alternative to the use of nasal continuous positive airway pressure (NCPAP) as a non-invasive modality to support respiratory distress in premature infants has been the recent introduction of high flow nasal cannula (HFNC) devices in many neonatal units. There ...
Tam Bonnie - - 2012
In this study, we evaluated the efficacy and safety of acetazolamide in the management of chronic metabolic alkalosis in neonates and infants with chronic respiratory insufficiency. A retrospective chart review of 90 patients treated with acetazolamide between 2006 and 2007 admitted to the neonatal intensive care unit was performed. Blood ...
Manley Brett J - - 2012
Background: High-flow nasal cannulae (HFNC) are gaining in popularity as a form of non-invasive respiratory support for preterm infants in neonatal intensive care units around the world. They are proposed as an alternative to nasal continuous positive airway pressure (NCPAP) in a variety of clinical situations, including post-extubation support, primary ...
Cohen-Wolkowiez Michael M Department of Pediatrics, Duke University, Durham, North Carolina 27715, - - 2012
Intra-abdominal infections are common in young infants and lead to significant morbidity and mortality. Meropenem is a broad-spectrum antimicrobial with excellent activity against pathogens associated with intra-abdominal infections. The purpose of this study was to determine the safety and effectiveness of meropenem in young infants with suspected or complicated intra-abdominal ...
Labiner-Wolfe Judith - - 2012
Background: Many mothers express and store their milk to later feed to their infant. Health organizations providerecommendations on expressed milk storage and handling because these practices can affect milk quality and safety. However, little information exists on US mothers' practices.Objective: To describe how US mothers of healthy infants store and ...
Cho June I - - 2012
Male vulnerability in health and growth outcomes has often been reported in very low birth weight (VLBW) preterm neonates. On the basis of gender-difference theories, possible associations were explored between the levels of postnatal salivary testosterone/cortisol and the outcomes of neonatal health/growth. This study used an exploratory and comparative research ...
Couch Robert - - 2012
Premature infants are known to have elevated 17-hydroxyprogesterone and adrenal androgen concentrations immediately after birth, but the levels decrease rapidly. Virilization of normal premature female infants as a result of these high androgens has not been described. Three premature female infants born at 24 to 25 weeks' gestation, with birth ...
James William H - - 2012
Baron-Cohen hypothesized that a cause of autism in infants is exposure to high concentrations of intrauterine testosterone concentrations. Some of the subsequent research on this hypothesis has focused on the possibility that the source of this testosterone is the fetus; however, this review shows that if the source is taken ...
1 2 3 4 5 6 7 8 9 10 >