Search Results
Results 51 - 100 of 924
1 2 3 4 5 6 7 8 9 10 >
Chen Minghua L ML Division of Newborn Medicine, Floating Hospital for Children at Tufts Medical Center, Box 854, 800 Washington St, Boston, MA 02111-1526, USA. - - 2010
Low oxygen saturation appears to decrease the risk of severe retinopathy of prematurity (ROP) in preterm newborns when administered during the first few weeks after birth. High oxygen saturation seems to reduce the risk at later postmenstrual ages (PMAs). However, previous clinical studies are not conclusive individually. To perform a ...
- - 2010
Previous studies have suggested that the incidence of retinopathy is lower in preterm infants with exposure to reduced levels of oxygenation than in those exposed to higher levels of oxygenation. However, it is unclear what range of oxygen saturation is appropriate to minimize retinopathy without increasing adverse outcomes. We performed ...
Massaro An - - 2010
This case series describes the clinical management of 5 infants who underwent whole-body cooling during extracorporeal membrane oxygenation (ECMO). In all 5 infants, systemic hypothermia was maintained during ECMO with acceptable clinical outcomes.
Jobe Alan H - - 2010
Preterm and term infants are frequently exposed to high concentrations of oxygen for prolonged periods. In experimental models, high and prolonged oxygen exposures cause delayed alveolar septation and a bronchopulmonary dysplasia phenotype. Often, however, the oxygen exposure is tolerated in that the infants recover without severe lung or systemic injury. ...
Dawson Jennifer A JA Neonatal Services, The Royal Women's Hospital, Melbourne, Australia. - - 2010
The goal was to define reference ranges for pulse oxygen saturation (Spo(2)) values in the first 10 minutes after birth for infants who received no medical intervention in the delivery room. Infants were eligible if a member of the research team was available to record Spo(2) immediately after birth. Infants ...
Dawson J A JA Neonatal Services, Newborn Research, The Royal Women's Hospital, 20 Flemington Road, Parkville, Victoria 3052, Australia. - - 2010
The normal range of heart rate (HR) in the first minutes after birth has not been defined. Objective To describe the HR changes of healthy newborn infants in the delivery room (DR) detected by pulse oximetry. Study Design All inborn infants were eligible and included if a member of the ...
Chua C O - - 2010
AIMS: Intraventricular haemorrhage (IVH) and cerebral injury are major neurological disorders of premature infants. The effect of hyperoxic resuscitation on the occurrence of IVH and cerebral injury is elusive. Therefore, we asked whether hyperoxia during neonatal resuscitation increased the incidence and severity of IVH and cerebral injury in premature newborns. ...
Stevens Timothy P - - 2010
Very low birth weight (VLBW) infants, even those without bronchopulmonary dysplasia (BPD) are at risk for pulmonary morbidity during infancy. Although some studies have found an association between the level of neonatal oxygen exposure and later morbidity, others have not. A possible explanation for these inconsistent findings is that the ...
Mills Bernice A - - 2010
OBJECTIVE: To determine if participation in a randomised controlled trial of different oxygen saturation targets improved compliance with oximeter alarm limit guidelines. DESIGN: Eligible infants were born after the commencement of the BOOST II trial. Data on alarm limits were collected on all infants <32 weeks' gestational age or birth ...
Dewhurst Chris - - 2010
AIMS: The aim of this study was to present data relating to the use of inhaled nitric oxide (iNO) in newborn infants included in the European Inhaled Nitric Oxide Registry. METHODS: Demographic, clinical and therapeutic data from seven European centres are reported. Univariate analyses were performed to identify factors associated ...
Aly H - - 2010
To examine the effect of regionalization of care on outcomes of neonates with congenital diaphragmatic hernia (CDH). Study Design: We analyzed the National Inpatient Sample and the 'Kids' database for the years 1997 to 2004. Infants with CDH were grouped based on whether they underwent surgical repair at the hospital ...
Vidmar Ivan - - 2010
Maintenance of adequate tissue oxygenation is an important task in intensive care units. There are many variables which are measured for this purpose. Central venous oxygen saturation (ScvO2) monitoring has some advantages over the mixed venous oxygen saturation (SvO2) monitoring in children and infants as there is no need to ...
Francis Johny Vakayil - - 2010
OBJECTIVE: To present the case of an extremely preterm infant with occlusive aortic arch clot managed with low-risk therapy. DATA SOURCE: Case details were obtained from medical records and echocardiographic images from Excelera database. STUDY SELECTION: Preterm infant with occlusive clot in the aortic arch. DATA EXTRACTION AND SYNTHESIS: Demographic ...
Ista Erwin - - 2010
To evaluate the feasibility of infants' weaning of opioids and sedatives at home. Retrospective observational study. Level 3 pediatric intensive care unit. Neonates treated for congenital diaphragmatic hernia (CDH) with extra corporeal membrane oxygenation (ECMO). Eligible infants were discharged early and further weaned of analgesics and/or sedatives at home. Of ...
Field David J DJ Department of Heath Science, Department of Health Sciences, University of Leicester, 22-28 Princess Road West, Leicester, UK. - - 2010
Existing evidence indicates that once mature neonates with severe cardio-respiratory failure become eligible for Extra Corporeal Membrane Oxygenation (ECMO) their chances of intact survival are doubled if they actually receive ECMO. However, significant numbers survive with disability. NEST is a multi-centre randomised controlled trial designed to test whether, in neonates ...
Ahmed Sally Jasmine Maia - - 2010
BACKGROUND: The effect of a pulse oximeter's averaging time on time spent by premature infants in established saturation ranges, as well as on desaturation events, has not previously been reported. OBJECTIVE: Our goal for this pilot study was to evaluate the effect of 2 distinct averaging times on the amount ...
Fauch?re Jean-Claude - - 2010
OBJECTIVE: In view of growing concerns regarding the optimal supplementation of oxygen at birth, we measured cerebral oxygenation during the first minutes of life. STUDY DESIGN: Using near-infrared spectroscopy, changes in cerebral oxygenated hemoglobin (O(2)Hb), dexoxygenated hemoglobin (HHb), and tissue oxygenation index (TOI) were measured during the first 15 minutes ...
Nuntnarumit P - - 2010
OBJECTIVE: To determine oxygen saturation (SpO(2)) trends in healthy preterm newborns during the first 15 min after birth and to ascertain factors affecting SpO(2) changes during that period. STUDY DESIGN: An observational study was conducted. Preterm newborns with gestational age (GA) less than 35 weeks, who did not require oxygen ...
Claure Nelson - - 2009
OBJECTIVE: To assess the efficacy of a system for automated fraction of inspired oxygen (FiO(2)) adjustment in maintaining oxygen saturation (SpO(2)) within an intended range in preterm infants with spontaneous fluctuations in SpO(2). STUDY DESIGN: Sixteen infants (gestational age, 24.9 +/- 1.4 weeks; birth weight, 678 +/- 144 g; age, ...
Shivananda Sandesh - - 2010
BACKGROUND: Although guidelines for mechanical ventilation, cardiovascular support and intravenous prostaglandin are well established, there is a lack of consensus regarding SpO(2) targets and safety of oxygen administration during transport of neonates with suspected congenital heart disease (CHD). In many centers, an SpO(2) range of 75-85% is targeted but there ...
Carey William A - - 2009
This review discusses the use of extracorporeal membrane oxygenation (ECMO) for the treatment of respiratory failure in neonates. After briefly reviewing the early history of neonatal ECMO, the authors describe the respiratory diagnoses most often treated with ECMO and the manner in which affected neonates are deemed to have "failed" ...
Kornhauser Cerar Lilijana - - 2009
OBJECTIVE: The purpose of this work was to compare the incidence of apnea, hypopnea, bradycardia, or oxygen desaturation in healthy term newborns placed in hospital cribs, infant car safety beds, or infant car safety seats. METHODS: A consecutive series of 200 newborns was recruited on the second day of life. ...
van den Berg E - - 2010
BACKGROUND: In preterm infants with respiratory distress syndrome (RDS) nasal continuous positive airway pressure (nCPAP) with the "InSurE" procedure (intubation, surfactant, extubation) is increasingly used. However, its effect on cerebral oxygenation and brain function is not known. OBJECTIVE: To evaluate the effects of the "InSurE" procedure in infants with RDS ...
Chakkarapani Ela - - 2009
BACKGROUND: Asphyxia accounts for 23% of the 4 million annual global neonatal deaths. In developed countries, the incidence of death or severe disability after hypoxic-ischemic (HI) encephalopathy is 1-2/1000 infants born at term. Hypothermia (HT) benefits newborns post-HI and is rapidly entering clinical use. Xenon (Xe), a scarce and expensive ...
Tina Lucia Gabriella - - 2009
Near Infrared Spectroscopy (NIRS) is an emerging technique for brain oxygenation monitoring in newborns complicated by acute and chronic hypoxia. However, data regarding cerebral oxygenation normal values are still lacking and matter of debate. Therefore, we investigate whether NIRS parameters in healthy preterm/term infants are gestational age and delivery modalities ...
Mhanna Maroun J - - 2009
Bronchodilators have been used in premature infants. Levalbuterol (LEV) an R-isomer of Albuterol has fewer hemodynamic side effects than Racemic Albuterol (RAC) in adults and children. In a retrospective study we sought to investigate the effects of LEV (0.31 mg) versus RAC (1.25 mg) in very low-birth weight infants (VLBW) ...
Verhagen Elise A - - 2009
OBJECTIVE: Our aim was to determine regional cerebral tissue oxygen saturation and fractional tissue oxygen extraction in preterm infants with transient periventricular echodensities. We hypothesized that as a result of reduced cerebral perfusion, regional cerebral tissue oxygen saturation will be lower and fractional tissue oxygen extraction will be higher during ...
- - 2009
The supply gas failure alarm on Cardinal Health Infant Flow SiPAP units manufactured before April 2009 may not activate in the event of a gas supply loss if the device's silencer accessory is attached. However, the unit's FiO2 (fraction of inspired oxygen) and low-airway-pressure alarms will activate in such cases. ...
Noori S - - 2009
OBJECTIVE: Postnatal increase in oxygen promotes constriction of the patent ductus arteriosus (PDA). According to the findings of prospective observational studies, the clinical practice of targeting lower fractional oxygen saturation between 70 and 90% has been associated with a reduced incidence of severe retinopathy of prematurity (ROP) without affecting survival ...
Chapman R L - - 2009
To explore how neonates with respiratory failure are selected for extracorporeal membrane oxygenation (ECMO) once severity of illness criteria are met, and to determine how conflicts between ECMO providers and parents over the initiation of ECMO are addressed. A cross-sectional study was conducted using a data collection survey, which was ...
Soll R F - - 2009
Inhaled nitric oxide (iNO) has been used to treat both term and preterm infants with respiratory failure. Term infants with persistent pulmonary hypertension, either as a primary cause or secondary to other disease processes, respond to iNO with improvement in oxygenation indices and a decreased need for extracorporeal membrane oxygenation. ...
Finer Neil - - 2009
Many of the morbid conditions associated with extreme immaturity are potentiated by an excess of free radicals occurring in infants who developmentally have decreased levels of antioxidants. The optimal oxygen saturation values for the resuscitation, stabilization, and ongoing care of the very low birth weight infant remain largely undefined. We ...
Kussman Barry D - - 2009
We examined changes in cerebral oxygen saturation during infant heart surgery and its relationship to anatomic diagnosis and early outcome. Regional cerebral oxygen saturation (rSO(2)) was measured by near-infrared spectroscopy in 104 infants undergoing biventricular repair without aortic arch obstruction as part of a randomized trial of hemodilution to a ...
Maltepe Emin - - 2009
Oxygen is critical for multicellular existence. Its reduction to water by the mitochondrial electron transport chain helps supply the metabolic demands of human life. The incompletely reduced, reactive oxygen byproducts of this reaction, however, can be quite toxic. In this review, we explore the mechanisms responsible for maintaining oxygen homeostasis ...
Hoo Ah-Fong - - 2009
RATIONALE: Despite encouraging reports suggesting that inhaled nitric oxide (iNO) appear to improve outcome in hypoxemic term and near term infants by improving oxygenation and reducing need for ECMO, the long-term benefits of iNO remain unclear. This study aimed to compare lung function at approximately 1 year in infants who ...
Sears Jonathan E - - 2009
PURPOSE: To determine the incidence of retinopathy of prematurity (ROP) over a 2-year period before and after a change in the practice of oxygen supplementation. DESIGN: Nonrandomized, retrospective study. PARTICIPANTS: All infants in a single Level III neonatal intensive care unit between the years of 2005 and 2007. METHODS: A ...
Ambalavanan Namasivayam - - 2009
BACKGROUND: We have shown earlier that inhaled nitric oxide (iNO) administered by oxygen hood reduces pulmonary hypertension in an animal model (J Perinatol 2002; 22:50-6). Our objective in this study was to determine feasibility of iNO by oxygen hood in neonates with elevated alveolar-arterial oxygen gradients (A-aDO(2)). METHODS/PRINCIPAL FINDINGS: Masked ...
Askie Lisa M - - 2009
While the use of supplemental oxygen has a long history in neonatal care, resulting in both significant health care benefits and harms, uncertainty remains as to the most appropriate range to target blood oxygen levels in preterm and low birth weight infants. Potential benefits of higher oxygen targeting may include ...
Ezaki Shoichi - - 2009
The objective of this study was to determine the effects of the level of inhaled oxygen during resuscitation on the levels of free radicals and anti-oxidative capacity in the heparinized venous blood of preterm infants. Forty four preterm infants <35 weeks of gestation with mild to moderate neonatal asphyxia were ...
Short B L - - 2008
Extracorporeal membrane oxygenation (ECMO) has been successful as a rescue therapy for infants with respiratory failure with some diagnoses such as meconium aspiration syndrome (MAS) having a survival rate of more than 94%. New therapies have allowed many infants who would have required ECMO to be kept off ECMO, but ...
Poore Meredith - - 2008
Sensory deprivation and motor restriction associated with extensive oxygen therapy may lead to poor oromotor control in preterm infants. Non-nutritive suck is one of the first complex oromotor behaviors infants perform. This study determined the spatiotemporal variability of non-nutritive suck (NNS) pressure trajectories in three preterm groups with differing oxygen ...
Rabi Y - - 2009
OBJECTIVE: To compare the rate of increase in oxygen saturation in babies receiving supplemental oxygen during resuscitation with those transitioning in room air. STUDY DESIGN: Prospective observational study. Infants were resuscitated with supplemental oxygen and continuous recording of preductal oxygen saturation was started immediately after birth. Oxygen saturation measurements from ...
- - 2008
Chronic neonatal lung disease (CNLD) is defined as a supplemental oxygen requirement beyond 36 weeks' postmenstrual age, with more severely affected infants requiring oxygen beyond a full-term-equivalent age. Low-flow supplemental oxygen facilitates discharge from hospital of infants with CNLD who develop hypoxia in air. There is a lack of data ...
Sorensen Line C - - 2008
Spatially resolved spectroscopy (SRS) allows the estimation of absolute tissue oxygen saturation, the ratio of oxygenated to total hemoglobin concentration, which may facilitate the comparison of results among patients. Eighty-two premature infants were included over two years. The cerebral tissue oxygenation index (c-TOI) was measured using NIRO 300 (Hamamatsu Photonics ...
Baba Lisa - - 2008
Free radical production occurs continuously in all cells as a by-product of cell metabolism. In tandem, the human body has developed endogenous antioxidant systems as well as taken advantage of dietary exogenous antioxidants to process and detoxify free radicals appropriately. However, certain conditions may increase free radical production beyond the ...
Lawson D Scott - - 2008
In early 2008, surveys of active extracorporeal membrane oxygenation (ECMO) centers in North America were conducted by electronic mail regarding neonatal ECMO equipment and professional staff. Eighty of 103 (78%) North American ECMO centers listed in the Extracorporeal Life Support Organization directory as neonatal centers responded to the survey. Of ...
Bare Jessica B - - 2008
Congenital diaphragmatic hernia (CDH) is a defect seen in approximately 1 in 3500 live births. A complication of CDH is the herniation of abdominal contents into the chest cavity through the defect, which may prevent normal intrauterine development of the lungs. The resultant pulmonary hypoplasia and pulmonary hypertension causes respiratory ...
Verklan M Terese - - 2008
PURPOSE: To report a serendipitous finding from a larger investigation describing physiologic variability of healthy and sick pre- and full-term neonates transitioning to extrauterine life in whom the oxygen arterial saturations rose to 90% very quickly. SUBJECTS: Thirty-four healthy pre- and full-term neonates and 40 sick pre- and full-term neonates. ...
Roemer V M - - 2008
BACKGROUND: Hypoxia and severe foetal acidosis may lead to cerebral injuries and multi-organ failure. Base excess (BE) and actual pH determined in umbilical artery (UA) blood are valid parameters to measure (metabolic) acidosis. Until now there is no consensus worldwide as to which of the two parameters should preferably be ...
Lacerenza Serafina - - 2008
BACKGROUND: Recently, a new sensor for combined assessment of pulse oximetry oxygen saturation (Spo(2)) and transcutaneous monitoring of carbon dioxide partial pressure (PtcCO(2)) has been introduced (TOSCA 500, Radiometer basel AG, Switzerland) [corrected] We designed this study to evaluate the usability and reliability of TOSCA in neonates with birth weight ...
1 2 3 4 5 6 7 8 9 10 >