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Lozoff Betsy - - 2007
Iron deficiency is widespread in infants and young children, especially in developing countries. Animal models provide convincing evidence that, despite iron repletion, iron deficiency during the brain growth spurt alters metabolism and neurotransmission, myelination, and gene and protein profiles. In the human, there is compelling evidence that 6- to 24-month-old ...
Lönnerdal Bo - - 2007
Meeting the iron requirements of infants and children is difficult, and supplementation or fortification of food with iron is often recommended. Although iron supplementation of infants and children with iron deficiency and iron-deficiency anemia may be beneficial, recent studies suggest that this may not be the case for those with ...
Lozoff Betsy - - 2008
To assess dose-response relationships between severity of iron deficiency (ID) and infant social-emotional behavior. The study group was a cohort of 9- to 10-month-old African-American infants (n = 77 with final iron status classification). The infants were given oral iron for 3 months. Social-emotional outcomes included mother and examiner ratings ...
Franchini Massimo - - 2007
Thrombotic thrombocytopenic purpura (TTP) is a severe multisystem thrombotic microangiopathy (TMA). Significant advances have been made in understanding the pathogenesis of TTP since the discovery of ADAMTS-13 ( A Disintegrin And Metalloproteinase with Thrombo Spondin-1-like domains), the enzyme that regulates the size of von Willebrand factor (VWF) multimers. The inherited ...
Spolter Yonatan S - - 2007
BACKGROUND: Little is known about how urea reduction ratio (URR) and hemoglobin (Hb) level relate as clinical performance measures (CPMs) in dialysis facilities. This study examined the relationship between these CPMs as a reflection of underlying processes. STUDY DESIGN: Cross-sectional observational. SETTING & PARTICIPANTS: 47,465 records from 18,003 patients dialyzed ...
Neu Josef - - 2007
The level of gastrointestinal (GI) maturity of an individual infant is a major determinant of whether the infant will be able to meet nutritional needs by sole use of the GI tract or if parenteral means will be necessary. The GI tract is not only an organ for digestion and ...
Schiza Vassiliki - - 2007
BACKGROUND: Preterm infants are at risk of developing iron deficiency; among the iron status and hemopoiesis indices the serum transferrin receptor (sTfr) has been shown to be a useful indicator in assessing iron status, while immature reticulocyte production is regarded as an estimator of erythropoiesis. OBJECTIVE: To investigate age-related changes ...
Dubey Maya - - 2007
Folate deficiency contributes to a variety of age-related neurological and psychological disorders including amyotrophic lateral sclerosis (ALS). The environmental neurotoxin arsenic has recently been linked with decreased neurofilament (NF) content in peripheral nerve. We examined herein, whether or not folate deprivation potentiated the impact of arsenic on NF dynamics. Arsenic ...
Carter R Colin - - 2007
OBJECTIVES: Our goals were to determine whether prenatal alcohol exposure is associated with an increased incidence of iron-deficiency anemia in infancy and to compare effects of fetal alcohol exposure and iron-deficiency anemia on infant growth. We also tested whether effects of fetal alcohol exposure on growth are mediated or moderated ...
Nassar M F - - 2007
Thymus size was assessed ultrasonographically and correlated to the percentage of CD4 and CD8 T-lymphocytes in peripheral blood in 32 infants with protein-energy malnutrition (PEM) and compared with 14 healthy control infants. The study revealed thymus atrophy in patients with PEM, especially the oedematous type, accompanied by changes in the ...
Kiechl-Kohlendorfer Ursula - - 2007
Transient, symptomatic zinc deficiency in breast-fed, low-birthweight infants is a rare, but probably underrecognized disorder hallmarked by periorificial and acral dermatitis. Unlike in acrodermatitis enteropathica, symptoms disappear when nursing ends. We report a breast-fed, preterm infant with demarcated, erythematous, and exudative patches with overlying crusts on the perioral, perianal, and ...
Abdelrazik Nabil - - 2007
OBJECTIVE: To weigh benefits of oral iron supplements on infant's growth against its potential hazards. METHODS: 248 exclusively breast-fed infants aged 4-6 months were consecutively enrolled and divided into treatment group given iron containing multivitamin (TG = 198) and control group (placebo, PG = 50) given the same multivitamin but ...
van Rheenen P F - - 2008
OBJECTIVE: To examine zinc-protoporphyrin (ZPP) and haemoglobin levels, and to determine predictors of iron deficiency anaemia (IDA) in Zambian infants. SUBJECTS AND METHODS: Ninety-one women and their normal birth weight (NBW) infants were followed bi-monthly during the first 6 months of life, and iron status, food intake, malaria parasitaemia and ...
Artac H - - 2007
The aim of this study was to contribute to clarify the mechanism of cellular immune insufficiency occurring during iron deficiency. We studied the expression of the transferrin receptor (TfR) which is called as CD71, on the surface of T lymphocytes in infants with iron deficiency (with and without anemia). A ...
Abbas Abdelhamid - - 2007
This study revealed that a Pseudomonas aeruginosa tonB1 mutant was unable to produce a mature biofilm and showed reduced swarming and twitching motilities compared with the parent strain. The tonB1 mutant was also found to produce significantly lower cell-free and cell-associated levels of the quorum sensing (QS) signal molecule 3-oxo-C12-AHL. ...
Bilenko Natalya - - 2007
BACKGROUND: Iron deficiency is the most prevalent anemia in infants and is known to be a major public health problem. OBJECTIVE: To examine mothers' knowledge and adherence with recommendations regarding iron supplementation and assess their association with the prevalence of anemia in infants. METHODS: Data on 101 infants and mothers ...
Braekke Kristin - - 2007
OBJECTIVE: To evaluate whether our current practice of giving iron 18 mg daily to 6-week-old infants with very low birth weight (VLBW) was associated with increased oxidative stress markers or decreased antioxidant status. STUDY DESIGN: The study was a prospective observational study of 21 healthy VLBW infants (born at gestational ...
Hay Gry - - 2007
BACKGROUND: Adequate iron status at birth may prevent iron deficiency in early childhood. OBJECTIVES: We aimed to identify predictors of serum ferritin (SF) and serum soluble transferrin receptor (sTfR) in healthy newborns and to relate these iron indexes to iron status in the first 2 y of life. DESIGN: Using ...
Tolentino Karine - - 2007
The highest prevalence of anemia exists in the developing world where its causes are multi-factorial. Anemia is responsible for significant morbidity and mortality, particularly in less developed countries (LDCs). Understanding causes of anemia and potential mechanisms are crucial to our ability to intervene to reduce this burden. In the past ...
van Rheenen P F - - 2007
Due to the insidious nature of infant anaemia, this disorder frequently remains undetected and untreated by health-care workers in resource-poor settings. We assessed the accuracy of a low-cost and simple diagnostic tool, the haemoglobin colour scale (HCS), in estimating haemoglobin (Hb) values in infants between zero and four months of ...
Grant Cameron C - - 2007
AIM: We aimed to develop policy in relation to three areas: (i) the diagnosis of iron deficiency; (ii) maternal-infant issues and the prevention of iron deficiency; and (iii) the treatment of iron deficiency. METHODS: Within each of these topic areas we completed a literature review and developed recommendations to help ...
Bergeron Raymond J - - 2007
The impact of introducing a 3,6,9-trioxadecyloxyl group at various positions of the desazadesferrithiocin (DADFT) aromatic ring on iron clearance and organ distribution is described. Three DADFT polyethers are evaluated: (S)-4,5-dihydro-2-[2-hydroxy-4-(3,6,9-trioxadecyloxy)phenyl]-4-methyl-4-thiazolecarboxylic acid [(S)-4'-(HO)-DADFT-PE, 3], (S)-4,5-dihydro-2-[2-hydroxy-5-(3,6,9-trioxadecyloxy)phenyl]-4-methyl-4-thiazolecarboxylic acid [(S)-5'-(HO)-DADFT-PE, 6], and (S)-4,5-dihydro-2-[2-hydroxy-3-(3,6,9-trioxadecyloxy)phenyl]-4-methyl-4-thiazolecarboxylic acid [(S)-3'-(HO)-DADFT-PE, 9]. The iron-clearing efficiency (ICE) in rodents and primates ...
Haliasos Elena C - - 2007
Zinc deficiency occurs in children when the demand for zinc exceeds its supply. Malnutrition, prematurity, total parenteral nutrition dependence, and burns increase the demand for zinc, whereas congenital malabsorption syndromes represent clinical situations where less zinc is supplied to the growing child. Clinical recognition of acral eczematous lesions, alopecia, and ...
Wieringa Frank T - - 2007
To evaluate effects of Fe supplementation and sex on the prevalence of anaemia and Fe status in infants in South-East Asia, biochemical data from four parallel, randomized, double-blind trials with Fe and/or Zn supplementation in infants (n 2452) in Indonesia, Thailand and Vietnam was pooled. At recruitment (5 months of ...
Risonar M G D - - 2008
OBJECTIVE: To determine the effect of a school-based weekly iron supplementation delivery system (WISDS) on the prevalence of anemia among anemic schoolchildren. SUBJECTS AND METHODS: Two hundred and forty-two Filipino schoolchildren aged 6-12 years with hemoglobin (Hb) concentration <12 g/dl and enrolled for school year 2003-2004. UNICEF iron-folate tablets containing ...
Rahimy Mohamed Cherif - - 2007
BACKGROUND: To study the efficacy of oral ferrous fumarate, an inexpensive, readily available preparation on iron deficiency in infants in Africa. PROCEDURE: Four months old (group 1, n = 252) and 6-18 months old (group 2, n = 360) healthy infants attending four primary health care centers (PHC) for vaccination/well-child ...
Nielsen Susanne - - 2007
OBJECTIVE: To investigate whether diet influences the composition of the intestinal microbiota in 10-month-old infants. PATIENTS AND METHODS: Fecal samples were collected from sixty-five 10-month-old infants participating in a randomized 2 x 2 intervention study comparing cow's milk (CM) with infant formula (IF) with or without fish oil (FO) supplement. ...
Urkin J - - 2007
AIMS: To estimate the prevalence of iron deficiency and iron deficiency anaemia using haematological indices. METHODS: Prospective interventional study. Healthy toddlers from Bedouin and Jewish towns in southern Israel. Capillary blood was sampled to assess iron status and nutritional history recorded. Parents were given specific nutritional instructions. Anaemia was defined ...
Marriott Lynne D - - 2007
To measure the zinc, copper, selenium and manganese blood levels in a cohort of 68 preterm infants, and to establish any associations with growth and/or dietary intake. Blood samples were collected at an infant's expected date of delivery (term) and 6 months later. Serum zinc, plasma copper and whole blood ...
Chiong M A - - 2007
A newborn boy with family history of severe ornithine transcarbamylase (OTC) deficiency was investigated prospectively and managed aggressively at birth based on an existing protocol for at risk neonates. Undetectable citrulline levels at birth suggested that the infant was affected; however, normal plasma glutamine and urine orotic acid levels confused ...
Golub Mari S - - 2007
Sensitive periods for induction of behavioral impairments by developmental iron deficiency were studied in a nonhuman primate model. Rhesus monkey infants were deprived of iron prenatally (n = 14) via the dam's diet (10 microg Fe/g) or postnatally (birth-4 mo, n = 12) via infant formula (1.5 mg Fe/L). They ...
Gariballa Salah - - 2007
Four hundred and forty-five randomly selected hospitalised patients had their nutritional status assessed from anthropometric, haematological and biochemical data. Nutritional status was compared between survivors and non-survivors at baseline, 6 weeks and 6 months. Using Cox's proportional hazard analysis, we measured the association between nutritional assessment variables and 1-year mortality ...
Pachón Helena - - 2007
BACKGROUND: Lyophilized meat powder with iron-fortified wheat flour can be used to produce an infant porridge with bioavailable iron, but its acceptability and safety are unknown. OBJECTIVE: To evaluate the acceptability and safety of porridges containing lyophilized meat powder and iron-fortified wheat flour. METHODS: Peruvian mothers' input was used to ...
Silva Danielle G - - 2007
OBJECTIVE: To investigate risk factors for anemia in infants assisted by public health services. METHODS: In a cross-sectional study carried out in Viçosa, state of Minas Gerais, Brazil, 205 children from 6 to 12 months were evaluated. Socioeconomic, environmental and biological data were collected, as well as information on child's ...
Suzuki A - - 2007
Among four ethnic groups in a lowland area of Nepal, the prevalences of abnormal haemoglobin, thalassaemia, glucose-6-phosphate-dehydrogenase (G6PD) deficiency, hereditary South-east Asian ovalocytosis (SAO) and Duffy blood-group antigen Fy/Fy were determined and related to each group's habitat. The group that has lived for many decades in a malaria-endemic lowland area, ...
Ray Amanda - - 2007
Iron deficiency is common in human immunodeficiency virus (HIV)-infected infants in sub-Saharan Africa. It is not known whether soluble transferrin receptor (sTfR) is a good indicator of iron deficiency in infants with HIV. We evaluated sTfR as an indicator of iron deficiency in 134 HIV-infected 9-month-old infants in Kampala, Uganda. ...
Krebs Nancy F - - 2007
Exclusive breastfeeding for the first 6 mo of life followed by optimal complementary feeding are critical public health measures for reducing and preventing morbidity and mortality in young children. Clinical factors, such as birth weight, prematurity, and illness, that affect the iron and zinc requirements of younger infants are discussed. ...
Beard John - - 2007
Infants are at risk for iron deficiency as breast milk or formula is replaced by semisolid foods during weaning. The scope of this article is to briefly review new findings on developmental iron deficiency and the persistence of deficiency effects into adulthood. A lack of sufficient iron intake may significantly ...
Arnon Shmuel - - 2007
The purpose of this study was to examine the efficacy and safety of early nonionic iron supplementation in preterm infants. Infants with gestational age < or = 32 weeks who were fed enriched human milk were assigned concurrently to receive 5 mg/kg/d enteral iron polymaltose complex (IPC) at 2 or ...
Wieringa Frank T - - 2007
Deficiencies of iron and zinc are prevalent worldwide. Interactions between these micronutrients therefore have important consequences, also for supplementation. To investigate effects on hemoglobin and zinc concentrations and interactions of iron and zinc supplementation in infants, data from 4 parallel, randomized, placebo-controlled, double-blind trials in Indonesia, Thailand, and Vietnam were ...
Lozoff Betsy - - 2007
The iron status of African-American infants continues to be subject to debate. We characterized the iron status of 198 9-month-old inner-city infants (94% fed iron-fortified formula) using a comprehensive panel of measures and assessing lead and inflammation markers. The proportion with iron deficiency was calculated based on three approaches (> ...
Osendarp Saskia J M - - 2007
BACKGROUND: Zinc deficiency is known to impair immunologic functions. However, the effect of zinc supplementation on immune response to polysaccharide vaccines is not known. OBJECTIVE: To determine the immunogenicity of the heptavalent Pneumococcal protein conjugate (PNC) vaccine in poor Bangladeshi infants and to assess the effect of zinc supplementation on ...
Alaattin Unsal
This aim of study was to determine the prevalence of anemia among infants from 4 to 11 months age and also to evaluate possible related risk factors with anemia. Hemoglobin level was determined by Hemocue hemoglobinometer in capillary blood samples. Anemia was diagnosed if hemoglobin (Hb) concentration was < 11.0 ...
Leblanc Caroline P - - 2007
PURPOSE: Iron deficiency anemia (IDA) during pregnancy and infancy is still common in developed countries, especially in low-income groups. We examined the prevalence of anemia and IDA in healthy low-income pregnant women participating in the Early Childhood Initiatives (ECI) program, and in their infants when they reached six months of ...
Vendt Neve - - 2007
BACKGROUND: The number of different laboratory tests and reference values are used to diagnose iron deficiency, but there is no agreement regarding the diagnostic criteria for infants. Aim of study. To establish reference values for serum ferritin, mean cell volume, and hemoglobin in infants aged from 9 to 12 months ...
Pulis Svetlana - - 2007
Hb F-Malta-I [Ggamma117(19)His-->Arg, CAT-->CGT] is a stable and benign variant of Hb F found in 1.8% of Maltese newborn. We studied 120 Hb F-Malta-I heterozygotes and four Hb F-Malta-I homozygotes. The mean proportion of Ggamma-F-Malta-I in Hb F was 0.26 +/- 0.03 for the Hb F-Malta-I heterozygotes and 0.58 +/- ...
Vendt Neve - - 2007
OBJECTIVE: To investigate the prevalence and causes of iron deficiency anemia in infants aged 9 to 12 months in Estonia. MATERIAL AND METHODS: Every second child aged 9-12 months was randomly selected from primary medical centers in seven counties from all over Estonia. A questionnaire concerning eating habits and lifestyle ...
Agostoni Carlo - - 2007
The complementary feeding period is a critical stage for growth and development. Infants in developing countries and selected individuals in developed countries may benefit from micronutrient supplementation, but long-term effects are still poorly explored. We have some evidence, coming from observational studies, of the role of iron in the second ...
Siddappa Ashajyothi M - - 2007
Serum ferritin measurements are used in clinical populations to estimate total body iron stores and the risk of subsequent iron deficiency or overload. The lack of normative newborn serum ferritin concentration data between 23 and 41 weeks has led to difficulty in establishing the incidence and degree of abnormal iron ...
Li Xin - - 2007
Borrelia burgdorferi survives in an enzootic cycle, and Dps proteins protect DNA against damage during starvation or oxidative stress. The role of a Dps homologue encoded by Borrelia in spirochaete survival was assessed. Dps-deficient spirochaetes were infectious in mice via needle-inoculation at the dose of 10(5) spirochaetes. Larval ticks successfully ...
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