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Robinson Shenandoah - - 2010
Epilepsy associated with preterm birth is often refractory to anticonvulsants. Children who are born preterm are also prone to cognitive delay and behavioral problems. Brains from these children often show diffuse abnormalities in cerebral circuitry that is likely caused by disrupted development during critical stages of cortical formation. To test ...
Himpens Eveline - - 2010
The aim of the study is to evaluate the predictive value of various types of brain injury detected by ultrasound in the neonatal period for the occurrence of cerebral palsy and its characteristics in a large cohort of high-risk infants. Thousand twenty-one consecutively NICU-admitted high-risk infants were assessed up to ...
Kato Toru - - 2010
We describe two infants with subcortical leukomalacia and decreased water diffusivity in widespread white matter on magnetic resonance imaging. In both infants, diffusion-weighted imaging at age 1 day revealed a widespread increase in signal intensities, predominantly in subcortical areas. The corticospinal tract in the brainstem was not involved. Subsequently, diffusion-weighted ...
Hahn Gitte Holst - - 2010
Coherence between spontaneous fluctuations in arterial blood pressure (ABP) and the cerebral near-infrared spectroscopy signal can detect cerebral autoregulation. Because reliable measurement depends on signals with high signal-to-noise ratio, we hypothesized that coherence is more precisely determined when fluctuations in ABP are large rather than small. Therefore, we investigated whether ...
Argyropoulou Maria I - - 2010
Children surviving premature birth present with a wide spectrum of motor, sensory and cognitive disabilities, ranging from slight motor deficits, school difficulties and behavioural problems to cerebral palsy and mental retardation. The anatomic and functional substrate of these problems can be investigated using a variety of imaging techniques. Cranial US ...
Breningstall Galen N - - 2010
Herpes encephalitis in neonates or young infants entails significant risk of mortality or morbidity. Prompt and aggressive treatment may lessen the chronic toll of herpes encephalitis. Unfortunately, an apparent uneventful recovery from herpes encephalitis may disguise evolving cerebral devastation. The discordance between evolving cerebral injury revealed by imaging and a ...
Belin Pascal - - 2010
In this issue of Neuron, Grossmann et al. provide the first evidence of voice-sensitive regions in the brain of 7-month-old, but not 4-month-old, infants. We discuss the implications of these findings for our understanding of cerebral voice processing in the first months of life.
Shah Prakesh S - - 2010
Hypothermia is a potential neuroprotective intervention to treat neonatal post-asphyxial (hypoxic-ischemic) encephalopathy (HIE). In this meta-analysis of 13 clinical trials published to date, therapeutic hypothermia was associated with a highly reproducible reduction in the risk of the combined outcome of mortality or moderate-to-severe neurodevelopmental disability in childhood. This improvement was ...
Adde Lars - - 2010
AIM: The aim of this study was to investigate the predictive value of a computer-based video analysis of the development of cerebral palsy (CP) in young infants. METHOD: A prospective study of general movements used recordings from 30 high-risk infants (13 males, 17 females; mean gestational age 31wks, SD 6wks; ...
Beaino Ghada - - 2010
AIM: The aim of this study was to assess the independent role of cerebral lesions on ultrasound scan, and several other neonatal and obstetric factors, as potential predictors of cerebral palsy (CP) in a large population-based cohort of very preterm infants. METHOD: As part of EPIPAGE, a population-based prospective cohort ...
Hill Jason J Departments of Pediatrics, Anatomy and Neurobiology, and Mechanical, Aerospace, and Structural Engineering, Washington University School of Medicine, St. Louis, Missouri 63108, USA. - - 2010
We have established a population average surface-based atlas of human cerebral cortex at term gestation and used it to compare infant and adult cortical shape characteristics. Accurate cortical surface reconstructions for each hemisphere of 12 healthy term gestation infants were generated from structural magnetic resonance imaging data using a novel ...
Hart Anthony R - - 2010
AIM: The aim of this study was to determine if apparent diffusion coefficients (ADCs) generated with diffusion-weighted imaging of cerebral white matter and the cerebellum are affected by white matter damage. METHOD: Seventy-two preterm infants (32 males, 40 females; mean gestational age at birth 30.3 wks, SD 3.0 wks; mean ...
Selder J - - 2010
BACKGROUND: Because deep hypothermic circulatory arrest (DHCA) carries a risk for neurological damage, antegrade cerebral perfusion (ACP) is used increasingly for aortic arch surgery in infants. We assessed the short-term effects of minimal DHCA (< 30 minutes) versus prolonged DHCA (> 30 minutes) during biventricular aortic arch reconstruction. METHODS: Twenty-six ...
Tina Lucia Gabriella - - 2010
Cerebral monitoring constitutes an emerging issue in perinatal medicine. Near Infrared Spectroscopy (NIRS) monitors brain oxygenation status in sick infants although data in healthy infants are lacking. The present study investigates whether NIRS parameters change according to gestational age and correlate with S100B protein. We recruited 64 healthy newborns (weeks' ...
Kułak W - - 2010
The aim of this study was to identify the antenatal, intrapartum and neonatal risk factors in term birth infants for cerebral palsy (CP) among babies in a hospital-based study. The medical records of children with cerebral palsy referred to our Pediatric Rehabilitation Department in Bialystok were reviewed. Antenatal, intrapartum, and ...
Angulo-Barroso Rosa M - - 2010
PURPOSE: This study described developmental changes in treadmill (TM) stepping and physical activity (PA) of infants at risk for neuromotor delay (ND) and explored these changes by diagnosis of cerebral palsy (CP). Relationships of stepping and PA with walking onset were examined. METHOD: Fifteen infants at risk for ND (9.9 ...
Foureur Maralyn J - - 2010
To develop a tool known as the Birth Unit Design Spatial Evaluation Tool (BUDSET), to assess the optimality of birth unit design. The space provided for childbirth influences the physiology of women in labor. Optimal birth spaces are likely to enable women to have physiologically normal labor and birth. The ...
Distefano Giuseppe - - 2010
Hypoxic-ischemic encephalopathy (HIE) is the most important cause of cerebral damage and long-term neurological sequelae in the perinatal period both in term and preterm infant. Hypoxic-ischemic (H-I) injuries develop in two phases: the ischemic phase, dominated by necrotic processes, and the reperfusion phase, dominated by apoptotic processes extending beyond ischemic ...
Leviton Alan - - 2010
Inflammatory phenomena seem to contribute to the occurrence of perinatal cerebral white matter damage and CP. The stimulus that initiates the inflammation remains obscure. One thousand two hundred forty-six infants born before the 28th postmenstrual week had a protocol ultrasound scan of the brain read concordantly by two independent sonologists. ...
Hielkema Tjitske - - 2010
It is widely accepted that infants at risk for cerebral palsy need paediatric physiotherapy. However, there is little evidence for the efficacy of physiotherapeutic intervention. Recently, a new intervention program, COPCA (Coping with and Caring for infants with special needs - a family centered program), was developed. COPCA has educational ...
Cummings David R DR - - 2010
This study tests whether seasonal differences in the United States and European sunshine is associated with human birth patterns. Birth data are adjusted for 31-day months, leap years, and an annual percentage. Clear observations and birth indices are correlated for European and U.S. cities. With 2-month exposure to clearness, r-values ...
Al-Qattan M M - - 2010
In this retrospective study we compared obstetric brachial plexus palsy (OBPP) in two non-operated groups of newborn babies delivered vaginally by breech or cephalic presentation. There were 35 cases of OBPP in the breech group and 663 cases in the cephalic group. The former group was more likely to develop ...
Fatemi Ali A Kennedy Krieger Institute, Department of Neurology, Johns Hopkins Medical Institutions, 707 N Broadway, Baltimore, MD 21205, - - 2009
Hypoxia-ischemia in the perinatal period is an important cause of cerebral palsy and associated disabilities in children. There has been significant research progress in hypoxic-ischemic encephalopathy over the last 2 decades, and many new molecular mechanisms have been identified. Despite all these advances, therapeutic interventions are still limited. In this ...
Maleki Zahra - - 2009
OBJECTIVE: To estimate whether there are placental histopathologic abnormalities associated with neonatal periventricular leukomalacia (PVL), a major precursor of cerebral palsy. METHODS: This is a case-control study of 167 neonates born between 23 and 34 weeks of gestation diagnosed with PVL by head ultrasonography within 6 weeks of birth, and ...
Fukuda Sumio - - 2010
Cerebral white matter injury, usually called periventricular leukomalacia (PVL), is the most common form of injury to preterm infants that is associated with adverse motor and cognitive outcomes. Intrauterine infection may be an important etiological factor in PVL, and premature rupture of the membranes (PROM) can be identified antepartum. In ...
Longo M - - 2009
Cerebral palsy (CP) affects 2/1 000 live-born children. There are several antenatal factors, including preterm delivery, low birth weight, infection/inflammation, multiple gestations, and other pregnancy complications, that have been associated with CP in both the preterm and term infant, with birth asphyxia playing a minor role. Due to the increasing ...
Horton Myles - - 2009
Vigabatrin, a gamma-aminobutyric acid (GABA) aminotransferase- inhibiting drug used for seizure control, has been associated with white matter vacuolation and intramyelinic edema in animal studies. Similar pathological lesions have never been described in the central nervous system of human participants treated with the drug. Described here is a child with ...
Johnson Jason M - - 2010
An infant who had an extensive cutaneous melanotic nevus with satellite lesions had cranial US for an unrelated problem. Small spherical echogenic foci in the cerebral and cerebellar parenchyma were identified. Subsequent MRI confirmed these as characteristic of melanotic deposits, thereby identifying this infant as having neurocutaneous melanosis.
Mahony R - - 2009
This was a retrospective review of term singleton neonates (> 37 weeks) with early onset seizures, with and without encephalopathy, from 1989 through 2000. Our aim was to examine the relationship between antepartum and intrapartum obstetric events, neonatal hypoxic seizures and subsequent neurological impairment of 77,838 infants, the incidence of ...
Wong Flora Y - - 2009
OBJECTIVE: Dopamine is widely used to maintain blood pressure in very preterm infants, but it may affect neurovascular regulation as it crosses the immature blood-brain barrier. We contrasted the relationship between cerebral perfusion and oxygen metabolism in preterm infants treated with dopamine because of hypotension with normotensive controls. DESIGN: Prospective ...
Costantine Maged M MM Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, Texas, USA. - - 2009
To review the evidence regarding neuroprotective effects of antenatal exposure to magnesium sulfate. We conducted database searches of MEDLINE, the Cochrane Library and Controlled Trials Register, as well as the ClinicalTrials.gov and International Clinical Trials Register websites. Bibliographies of all relevant articles were reviewed. Randomized controlled trials comparing magnesium sulfate ...
Malamateniou C C Department of Imaging Sciences, Imperial College London, London, UK. - - 2009
It has been shown that the brain of a preterm infant develops differently from that of a term infant, but little is known about the neonatal cerebrovascular anatomy. Our aims were to establish reference data for the prevalence of the anatomic variations of the neonatal circle of Willis (CoW) and ...
Himpens Eveline - - 2010
The aim of this study is to investigate the interrelationship between gestational age (GA) and nosologic characteristics (type, distribution and severity) of cerebral palsy (CP) in a cohort of high-risk infants. One thousand ninety-nine consecutively neonatal intensive care unit-admitted high-risk infants (i.e., all infants with a GA less than 30 ...
Hagmann Cornelia F - - 2009
PURPOSE: To compare quantitative T2 relaxometry of cerebral white matter (WM) with qualitative assessment of conventional T2-weighted magnetic resonance (MR) images, to assess the relationship between cerebral WM T2 and region-specific apparent diffusion coefficient (ADC), and to examine WM T2 regional variation in preterm infants at term. MATERIALS AND METHODS: ...
Ravn Susanne Holst - - 2010
The Cerebral Palsy Registry in eastern Denmark has been collecting cases using a uniform data sampling procedure since birth year 1979. Children are included by two child neurologists and an obstetrician. Information on pregnancy, birth, neonatal period, impairments and demographic data are registered. The total cerebral palsy birth prevalence has ...
Okumura Akihisa - - 2009
OBJECTIVE: We sought to clarify the features of kernicterus in preterm infants. METHODS: The subjects of this study were 8 preterm infants with athetoid cerebral palsy whose gestational ages were < or =34 weeks. We retrospectively investigated clinical, laboratory, MRI, and brainstem auditory evoked potential (BAEP) findings. RESULTS: Gestational age ...
Ligam Poonam - - 2009
Despite major advances in the long-term survival of premature infants, cognitive deficits occur in 30-50% of very preterm (<32 gestational weeks) survivors. Impaired working memory and attention despite average global intelligence are central to the academic difficulties of the survivors. Periventricular leukomalacia (PVL), characterized by periventricular necrosis and diffuse gliosis ...
Pellicer Adelina - - 2009
BACKGROUND: The duration and severity of systemic hypotension have been related with altered neurodevelopment. Cerebral circulation is pressure-passive in low birth weight infants with early systemic hypotension who receive cardiovascular support. The treatment of early systemic hypotension is controversial, because it has been associated with short-term and long-term morbidity in ...
Brown Nisha C - - 2009
OBJECTIVE: To examine the relationship between very preterm infant neurobehavior at term and concurrent magnetic resonance-defined cerebral abnormalities. STUDY DESIGN: 168 very preterm infants (birth weight <1250 g or gestation <30 weeks) were examined at term with 2 standardized neurobehavioral assessments, the Revised Hammersmith Neonatal Neurological Examination and the Neonatal ...
Krägeloh-Mann Ingeborg - - 2009
A common language on CP has been developed for the European registers by the SCPE (Surveillance of Cerebral Palsy in Europe) working group and the common database allows prevalence analyses on a larger basis. CP prevalence increases with lower birthweight and higher immaturity. Increase of survival after preterm birth has ...
Lightburn Marla H MH Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, - - 2009
To determine whether extremely low birth weight (ELBW) infants with hypotension have similar cerebral hemodynamics when compared with control subjects with normal blood pressure. We hypothesized that ELBW infants with low or normal blood pressure have similar cerebral blood flow (CBF) velocity. In this case control study, CBF velocity (with ...
Kusaka Takashi - - 2009
The aim of this study was to evaluate the hypothesis that cerebral hemoglobin (Hb) oxygenation is related to phosphorylation potential during primary and secondary cerebral energy failure in newborn infants who have experienced birth asphyxia. We subjected newborn piglets to severe transient cerebral hypoxic-ischemia followed by resuscitation and examined cerebral ...
Barnette Alan R - - 2009
Ischemic perinatal stroke (IPS) occurs in 1 of 2300 to 5000 live births. It is an under-recognized cause of significant long-term disabilities, including hemiplegic cerebral palsy, epilepsy, cognitive delays, and behavioral impairments. The pathophysiology is complex and multifactorial, involving maternal, fetal, placental, and neonatal factors. Knowledge and interventions are emerging ...
de Campos Ana Carolina - - 2009
Although the influence of intrinsic and extrinsic factors on the development of reaching and grasping skills in typical infants has been extensively described in the literature, the effect of such factors on at-risk infants is still poorly understood. Therefore, the aims of the present study were to analyze the scientific ...
Baschat A A - - 2009
OBJECTIVES: To evaluate the relationship between fetal Doppler parameters, biophysical profile score (BPP) and neurodevelopmental delay at 2 years of corrected age in infants who had been growth-restricted in utero. METHODS: This was a prospective observational study including 113 pregnancies complicated by intrauterine growth restriction (IUGR) (abdominal circumference<5th percentile and ...
Ustad Tordis - - 2009
PURPOSE: This study was designed to examine effects of blocks of daily physiotherapy in 5 infants with cerebral palsy. METHODS: A single-subject design was used. Intervention consisted of two 4-week periods of daily physiotherapy, interrupted by 8 weeks of physiotherapy as usual. The children were assessed every 4th week using ...
Mooney James F JF - - 2009
This study examined the seasonal birth patterns of patients with cerebral palsy (CP) in North Carolina. Data regarding live births in North Carolina were obtained for years 1980 to 2002 from the National Center for Health Statistics. Data from a pediatric orthopaedic multidisciplinary cerebral palsy clinical database at a regional ...
Lingwood B E - - 2009
OBJECTIVE: Changes in cerebral impedance in the newborn piglet are able to discriminate, within 1-2 h of acute hypoxia, between animals which will have a good neurological outcome, and those who have suffered more severe hypoxia resulting in poor outcome. The aim of this study was to determine if cerebral ...
Halliday Henry L - - 2009
Chronic lung disease (CLD) remains a major problem in neonatal intensive care units. Persistent inflammation in the lungs is the most likely underlying pathogenesis. Corticosteroids have been used to either prevent or treat CLD because of their potent anti-inflammatory effects. To determine if postnatal corticosteroid treatment is of benefit in ...
Shankaran Seetha - - 2008
The incidence, risk factors, and etiology of cerebral palsy (CP) are reviewed based on evidence-based data. Current methods for diagnosing risk for brain injury, including neuroimaging data on CP in this group of infants are presented. Prevention of CP in term and near-term infants currently seems to be promising with ...
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