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Simons Emily A EA Kid Risk, Inc, Orlando, FL, USA; Harvard Medical School, Boston, MA, - - 2014
Congenital rubella syndrome (CRS) continues to cause disability among unvaccinated populations in countries with no or insufficient rubella vaccine coverage to prevent transmission. We systematically reviewed the literature on birth outcomes associated with CRS to estimate the duration, severity, and frequency of combinations of morbidities. We searched PubMed, the Science ...
Smee N N NHS Greater Glasgow and Clyde, Area Perinatal Effectiveness Committee, Glasgow, - - 2014
Neonatal hypoxic-ischaemic encephalopathy (HIE) is the most common cause of neurological deficit in near-term infants. It is estimated to affect 2-3 neonates per 1000 live births. Controlled hypothermia can improve neonatal outcomes. The therapy has been available within tertiary level Neonatal Units in NHS GGC subsequent to the seminal UK ...
Skranes J H JH Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, - - 2014
Background: Severe neonatal encephalopathy (NE) of hypoxic-ischaemic origin may cause death or life-long disability. Acute encephalopathy may also affect cerebrovascular control. Pourcelot's cerebrovascular resistance index (RI) ≤0.55 was predictive of poor outcome in normothermic NE infants. Recent studies have questioned its predictive power during therapeutic hypothermia (HT). Objective: To assess ...
Darlow Brian A BA Department of Pediatrics, University of Otago, Christchurch, New Zealand. Electronic address: - - 2014
To assess whether an oxygen saturation (Spo2) target of 85%-89% compared with 91%-95% reduced the incidence of the composite outcome of death or major disability at 2 years of age in infants born at <28 weeks' gestation. A total 340 infants were randomized to a lower or higher target from ...
Gardiner Jackie J Department of Neonatology, Princess Margaret Hospital, Perth, - - 2014
Therapeutic hypothermia is the standard clinical practice for neonates with moderate to severe hypoxic ischaemic encephalopathy (HIE). To describe the two year neurodevelopmental outcomes of neonates who were routinely cooled using cool gel packs for HIE in Western Australia. Retrospective study. Cases were identified from the neonatal databases. Information was ...
Zhang Jie J Department of Pediatrics, The Affiliated Hospital of Jiangsu University, 438 Jiefang Road, Zhenjiang 212001, Jiangsu Province, PR - - 2014
Neonatal brain injury caused by extreme prematurity remains a great challenge for prevention. Erythropoietin (EPO) has shown neuroprotective effects in a series of neonatal experimental models and recent clinical trials of premature infants. In this meta-analysis of seven clinical trials, EPO was associated with a highly reproducible reduction in the ...
Alshaikh B B 1] Department of Community Health Sciences, Faculty of Medicine, University of Calgary, Calgary, AB, Canada [2] Department of Pediatrics, University of Calgary, Calgary, AB, - - 2013
Objective:The objective of this study was to examine the impact of Coagulase-negative staphylococcus (CoNS) sepsis in preterm infants on the neurodevelopmental outcomes at 30 to 42 months corrected age (CA).Study Design:This is a retrospective cohort study. All preterm infants born at <29 weeks gestational age between 1995 and 2008 and ...
Cotten C Michael - - 2013
Background:Adults with the apolipoprotein E gene (APOE) alleles e4 and e2 are at high risk of poor neurologic outcome after brain injury. The e4 allele has been associated with cerebral palsy and the e2 allele has been associated with worse neurologic outcome with congenital heart disease. This study was done ...
Blencowe Hannah H Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, - - 2013
Background:Neonatal mortality and morbidity are increasingly recognized as important globally, but detailed estimates of neonatal morbidity from conditions and long-term consequences are yet to be published.Methods:We describe the general methods for systematic reviews, meta-analyses, and modeling used in this supplement, highlighting differences from the Global Burden of Disease (GBD2010) inputs ...
Forster S - - 2013
The interactions experienced by adults with profound intellectual and multiple disabilities (PIMD) with their disability support workers (DSWs) may have a large impact on life quality. However, defining good-quality interaction has presented challenges for this group. It has been suggested that in typically developing infant-mother dyads, the presence of affect ...
Keir Amy A Department of Neonatal Medicine, Women's and Children's Hospital Network, Adelaide, - - 2014
To report survival, morbidity and neurodevelopmental outcome in a cohort of extremely low birthweight infants. Retrospective cohort study of all inborn infants born alive with birthweights ≤500 g ≥22 weeks gestation at Women's and Children's Hospital, Adelaide, Australia, over a 6-year period (2005-2010). Outcome data including standardised medical and psychological assessments ...
Lee Tzu-Ying - - 2013
This study explores the perceptions and experiences of Taiwanese parents in coping with the unfolding evidence of a disability, their response to the official diagnosis, and their views about their child's developmental disability. This descriptive qualitative study is a partial analysis of data from a larger study including 19 Taiwanese ...
Vohr Betty - - 2013
At present, moderate preterm (MPT) infants born at 32 to 33 weeks' gestation and late preterm (LPT) infants born at 34 to 36 weeks' gestation make up the largest subgroup of preterm infants and contribute to more than 80% of premature births in the United States. There is increasing evidence that both ...
Cacciani Laura - - 2013
This study aimed at exploring the relationship between severe neuromotor and/or sensory disability in very preterm infants assessed at 2 years corrected age and their mothers' psychological health. Data on 581 Italian singletons born at 22-31 weeks of gestation in five Italian regions and their mothers were analyzed. Maternal psychological ...
Natarajan Girija G Department of Pediatrics, Wayne State University, , Detroit, Michigan, - - 2013
To determine the association between 10 min Apgar scores and 6-7-year outcomes in children with perinatal hypoxic-ischaemic encephalopathy (HIE) enrolled in the National Institute of Child Health and Human Development Neonatal Research Network (NICHD NRN) whole body cooling randomised controlled trial (RCT). Evaluations at 6-7 years included the Wechsler Preschool ...
Schmidt Barbara B Division of Neonatology, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, Philadelphia, PA, USA. - - 2013
The goal of oxygen therapy is to deliver sufficient oxygen to the tissues while minimizing oxygen toxicity and oxidative stress. It remains uncertain what values of arterial oxygen saturations achieve this balance in preterm infants. To compare the effects of targeting lower or higher arterial oxygen saturations on the rate ...
Lederman Zohar - - 2013
The argument advanced by Giubilini and Minerva is an important one, but it suffers from some shortcomings. I briefly criticise their reasoning and method and argue that after birth abortion should be limited largely to infants with disabilities. My argument is based not on solid scientific evidence or cold rational ...
Serenius Fredrik F Department of Women's and Children's Health, Section for Pediatrics, Uppsala University, S-751 85 Uppsala, Sweden. - - 2013
Active perinatal care increases survival of extremely preterm infants; however, improved survival might be associated with increased disability among survivors. To determine neurodevelopmental outcome in extremely preterm children at 2.5 years (corrected age). Population-based prospective cohort of consecutive extremely preterm infants born before 27 weeks of gestation in Sweden between ...
Molnár Zoltán Z Department of Physiology, Anatomy and Genetics, University of Oxford, Le Gros Clark Building, South Parks Road, Oxford OX1 3QX, UK. - - 2013
Two translational studies--one in humans and one in sheep--suggest that (i) premature birth is associated with delayed maturation of grey matter in the cerebral cortex and (ii) medical care that prohibits impairment of growth in premature neonates may enhance cortical development and reduce neurological disabilities associated with preterm birth.
Baud Olivier - - 2013
Neonatal meningitis contributes substantially to neurological disability worldwide. Its incidence remains low but is significantly higher in neonates with documented sepsis, preterm infants, and when meningitis is nosocomial. Neonates are at higher risk of meningitis because of immaturity in humoral and cellular immunity, and the absence of specific clinical signs ...
Jacobs Susan E - - 2013
Newborn animal studies and pilot studies in humans suggest that mild hypothermia following peripartum hypoxia-ischaemia in newborn infants may reduce neurological sequelae without adverse effects. To determine the effect of therapeutic hypothermia in encephalopathic asphyxiated newborn infants on mortality, long-term neurodevelopmental disability and clinically important side effects. We used the ...
Holmgren Calla M - - 2012
Uterine rupture during attempted vaginal birth after cesarean is a rare, but serious complication and can result in death or long-term disability. Several factors can increase the risk of uterine rupture during vaginal birth after cesarean and adequate counseling is necessary. Current literature suggests that timely diagnosis and delivery of ...
Memon Shazia - - 2012
To determine the frequency of birth asphyxia and short-term (early) outcome in relation to age at admission and place of delivery. A descriptive cross-sectional study was conducted in the Paediatric Department, Neonatal Ward of Liaquat University Hospital (LUH) Hyderabad from January to December 2009. All babies were received at our ...
Boland Rosemarie A - - 2012
BACKGROUND: The aim of this study was to determine if the National Institute of Child Health and Human Development (NICHD) calculator, designed to predict mortality or neurosensory disability in infants 22-25 weeks' gestation, was valid for contemporary Australian infants. METHOD: Outcome data at 2 years of age for 114 infants ...
Jary Sally - - 2012
BACKGROUND: Infants with post-haemorrhagic ventricular dilatation (PHVD) have a high risk of severe disability and parenchymal infarction increases this risk. Existing cranial ultrasound (CUS) markers of neurodevelopmental outcome are based on categorical features. OBJECTIVE: To investigate to what extent quantitative CUS measurements correlated with severity of developmental outcome and the ...
Peliowski-Davidovich Abraham - - 2012
Hypoxic ischemic encephalopathy (HIE) remains a significant cause of mortality and long-term disability in late preterm and term infants. Mild therapeutic hypothermia to a rectal temperature of 34±0.5°C initiated as soon as possible within the first 6 h of life decreases mortality and severe long-term neurodevelopmental disabilities in infants with ...
Schlapbach Luregn J - - 2012
While survival rates of extremely preterm infants have improved over the last decades, the incidence of neurodevelopmental disability (ND) in survivors remains high. Representative current data on the severity of disability and of risk factors associated with poor outcome in this growing population are necessary for clinical guidance and parent ...
Shanklin D Radford - - 2011
Normally developed thyroid function is critical to the transition from fetal to neonatal life with the onset of independent thermoregulation, the most conspicuous of the many ways in which thyroid secretions act throughout the body. A role for thyroid secretions in growth and maturation of the lungs as part of ...
Srinivasan R - - 2011
Aim:  Transient fluctuations in thyroid function are well recognized in preterm infants. We wanted to assess TSH variation in babies with transient and permanent congenital hypothyroidism (CHT). Methods:  Whole bloodspot TSH data in preterm infants (<35 weeks; 2005-2010) were assessed and infants with bloodspot TSH values >6mU/l identified. Permanent CHT ...
Zuk Luba - - 2011
The challenge of identifying infants who are at risk for developmental delay and possible adverse neurodevelopmental outcome demands methods of evaluation that will lead to early intervention to minimize developmental disability and to maximize the infant's potential. A qualitative assessment of spontaneous general movements (GMs) in the preterm, term, and ...
Menon Kavitha C - - 2011
Background: An adequate intake of iodine during pregnancy is essential for the synthesis of maternal thyroid hormones needed to support normal fetal development. This study aimed to assess the iodine status of pregnant tribal Indian women and their infants and to determine the impact of maternal iodine status on infant ...
Hallett Andrew - - 2011
Congenital hypothyroidism is screened for in the UK using blood spot thyroid-stimulating hormone (TSH) screening at 5-8 d of age. Although standards are set by the UK Newborn Screening Programme Centre, there are variations in TSH cut-offs used. The introduction of repeat screening of preterm babies at 36 weeks' gestational ...
Hoshiko Sumi - - 2011
Thyroid hormones substantially influence central nervous system development during gestation. We hypothesized that perturbations of early thyroid profiles may contribute to the development of autism spectrum disorders (ASD). Thyroid pathways could provide a mechanism by which environmental factors that affect the thyroid system may impact autism occurrence or phenotypic expression. ...
Balapatabendi Mihirani - - 2011
Infacol (Forest Laboratories UK, Kent, UK) is a widely available over-the-counter preparation used to relieve colic symptoms in neonates and infants. The active ingredient is simeticone. No drug interactions with simeticone are documented in the current summary of product characteristics. The authors report the case of an infant with confirmed ...
Zimmermann Michael B - - 2011
Iodine is an essential component of the hormones produced by the thyroid gland. Thyroid hormones, and therefore iodine, are essential for mammalian life. Iodine deficiency is a major public health problem; globally, it is estimated that two billion individuals have an insufficient iodine intake. Although goiter is the most visible ...
Yao Dan - - 2011
Objectives- The purposes of this study were to determine thyroid volumes in healthy Chinese infants aged 0 to 12 months and to provide reference data for normal thyroid growth. Methods- A total of 408 healthy infants (229 male and 179 female) were enrolled in the study. The length, breadth, and ...
Bhavani Nisha - - 2011
Transient thyroid function abnormalities in the new born which revert back to normal after varying periods of time are mostly identified in the neonatal screening tests for thyroid and are becoming more common because of the survival of many more premature infants. It can be due to factors primarily affecting ...
Evans Carol - - 2011
We describe seven infants with transient congenital hypothyroidism (CH) due to maternal thyroid-stimulating hormone receptor (TSH-R) blocking antibodies (TRAb) identified over three decades of newborn screening for CH in Wales, UK that represents a minimum incidence of 1.6% of CH cases. Infants with transient CH due to maternal TRAb presented ...
Sexson William R - - 2011
Current United States guidelines for neonatal resuscitation note that there is no mandate to resuscitate infants in all situations. For example, the fetus that at the time of delivery is determined to be so premature as to be non-viable need not be aggressively resuscitated. The hypothetical case of an extremely ...
Janvier Annie - - 2011
Decisions for critically ill infants with trisomy 18 raise thorny issues about values, futility, the burdens of treatment, cost-effectiveness, and justice. We presented the case of an infant with trisomy 18 to 2 neonatologists with experience in clinical ethics, Annie Janvier and Felix Okah, and to a parent, Barbara Farlow. ...
Ng Sze May - - 2011
All screening programmes in the UK use a primary thyroid stimulating hormone (TSH) screen for congenital hypothyroidism. Recent attention has been paid to aspects of screening, such as the relation between blood spot TSH levels and birth weight or gestational age. The aim of our study was to determine the ...
Roggero Paola - - 2010
Nutrition in early life, growth, and subsequent health over a lifetime are significantly interrelated. The aim of this study was to assess body composition changes in exclusively breast-fed infants from birth up to 6 mo of age. An observational, prospective, cohort study was conducted. Fifty-nine full-term, healthy, exclusively breast-fed infants ...
Buxmann Horst - - 2010
  To evaluate the enteral feeding practice of preterm infants <32 weeks (W) gestational age (GA) or <1500 g birth weight (BW) from human cytomegalovirus (HCMV)-seropositive mothers in Germany, Austria and Switzerland.   This prospective cross-sectional study included all neonatal units (NU) admitting preterm infants <32W or <1500g BW in Germany, Austria ...
Möllborg P - - 2011
Aim:  In spite of several reports of an increased risk of sudden infant death syndrome (SIDS) in connection with bed-sharing, it is not an uncommon practice. The aim of this study was to examine bed-sharing at 6 months of age and the factors that are associated with bed-sharing. Methods:  Our cohort ...
Clark Alena - - 2011
Abstract Objective: This project describes the development of a protocol that compared issuing multi-user electric breast pumps to single-user breast pumps for Special Supplemental Nutrition Program for Women, Infants and Children (WIC) participants. Methods: Forty breastfeeding mothers participating in WIC who were separated from their infants ≥30 hours a week, ...
Chen Lei - - 2010
Epilepsy is a relatively common maternal complication affecting 0.3-0.5% of pregnant women. For most mothers with epilepsy, the use of antiepileptic drugs (AED) is unavoidable, even during pregnancy and lactation. Therefore, the fetus is indirectly exposed to AED via the placenta and breast milk. AED are also prescribed for female ...
Roger Laure C - - 2010
Bifidobacteria in the infant faecal microbiota have been the focus of much interest, especially during the exclusive milk-feeding period and in relation to the fortification of infant formulae to better mimic breast milk. However, longitudinal studies examining the diversity and dynamics of the Bifidobacterium population of infants are lacking, particularly ...
Tarrant Roslyn C - - 2010
The WHO (2001) recommends exclusive breast-feeding and delaying the introduction of solid foods to an infant's diet until 6 months postpartum. However, in many countries, this recommendation is followed by few mothers, and earlier weaning onto solids is a commonly reported global practice. Therefore, this prospective, observational study aimed to ...
Fallani Matteo - - 2010
: There are many differences in diet and lifestyle across Europe that may influence the development of the infant gut microbiota. This work aimed to assess the impact of geographic area, mode of delivery, feeding method, and antibiotic treatment on the fecal microbiota of infants from 5 European countries with ...
Edwards Taryn M - - 2010
This manuscript describes an innovative nurse-driven continuous quality improvement project. Infants born with congenital surgical anomalies face significant challenges within the newborn period and human milk/breast-feeding may not be viewed as a priority. In many hospitals, nurses refer families to lactation consultants for all breast-feeding assistance and support. The Transition ...
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