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Kwan Antonia A Department of Pediatrics, University of California, San Francisco, San Francisco2UCSF Benioff Children's Hospital, San Francisco, - - 2014
Newborn screening for severe combined immunodeficiency (SCID) using assays to detect T-cell receptor excision circles (TRECs) began in Wisconsin in 2008, and SCID was added to the national recommended uniform panel for newborn screened disorders in 2010. Currently 23 states, the District of Columbia, and the Navajo Nation conduct population-wide ...
Lu Fang-Ting FT *Department of Pediatrics, National Taiwan University College of Medicine and Hospital, Taipei, Taiwan †Department of Pediatrics, Cardinal Tien Hospital Yonghe Branch, New Taipei city, Taiwan ‡Department of Primary Care Medicine, National, Taiwan University College of Medicine, Taipei, - - 2014
Low gamma-glutamyl transpeptidase (GGT) level is an important marker for progressive familiar intrahepatic cholestasis (PFIC), yet the cutoff level and clinical application is not well defined. This study aimed to evaluate the role of GGT as a screening marker among diverse etiologies of infantile cholestasis. This retrospective study analyzed 256 ...
Hawkes Ga G Department of Neonatology, Cork University Maternity Hospital, Ireland; Department of Paediatrics and Child Health, University College Cork, - - 2014
The physiologic adaptation to extra uterine life during the immediate neonatal period is unique. Many newborns require assistance in this adaptive process. Recent evidence now supports titrating oxygen to guide resuscitation but no guidance is provided on utilizing exhaled CO2 measurements. To review the current evidence relating to the use ...
Fuchs E M EM Division of Newborn Medicine, Department of Pediatrics, Creighton University School of Medicine, Omaha, NE, USA University of Utah Pediatric Residency Program, Salt Lake City, UT, - - 2014
Umbilical vessel catheterization is common practice for infants in the neonatal intensive care unit (NICU). Umbilical venous catheters (UVC) although very useful as a means of obtaining vascular access, do not come without risks. Here we will describe three separate cases of infants in the NICU who, during their course ...
Granelli Anne de-Wahl AD Department of Paediatric Cardiology, Queen Silvia Children's Hospital, Sahlgrenska University Hospital, Gothenburg, - - 2014
Pulse oximetry screening of newborn infants increases early detection of critical congenital heart disease and minimises the risk of circulatory collapse before surgery. This study provides an update on the implementation of pulse oximetry screening in the Nordic countries and proposes standardised guidelines. A questionnaire exploring pulse oximetry screening, clinical ...
Mahieu Ludo - - 2014
Despite group B streptococcal (GBS) screening in late pregnancy and intrapartum antimicrobial prophylaxis, early-onset sepsis in neonates remains a common source of neonatal morbidity and mortality especially in preterm neonates. The identification of neonates with early-onset sepsis is usually based on perinatal risk factors. Clinical signs are aspecific and laboratory ...
Manja V V 1] Divisions of Cardiology, State University of New York at Buffalo, Buffalo, NY, USA [2] Clinical Epidemiology and Biostatistics (Health-Research Methodology), McMasters University, Hamilton, ON, - - 2014
Objective:Critical congenital heart disease (CCHD) screening is effective in asymptomatic late preterm and term newborn infants with a low false-positive rate (0.035%). (1) To compare 2817 neonatal intensive care unit (NICU) discharges before and after implementation of CCHD screening; and (2) to evaluate CCHD screening at <35 weeks gestation.Study Design:Collection ...
Vehmas Tapio T Health and Work Ability, Finnish Institute of Occupational Health, Topeliuksenkatu 41 a A, FI-00250 Helsinki, Finland. Electronic address: - - 2014
To study associations between chest HRCT signs and subsequent deaths in long-term follow-up. Lung and pleural signs of 633 asbestos exposed workers (age 45-86, mean 65) screened with HRCT were recorded by using the International Classification of Occupational and Environmental Respiratory Diseases (ICOERD) system, which contains detailed instructions for use ...
Holmström Gerd G Department of Neuroscience/Ophthalmology, University Hospital, Uppsala, - - 2014
To investigate whether recent Swedish guidelines for Retinopathy of Prematurity (ROP) screening, that is, a gestational age (GA) at birth of <31 weeks (w), are applicable in a new national cohort of prematurely born infants. SWEDROP is a national register for ROP, initiated in 2006. The present paper reports on data ...
Krajčovič Jozef J Institute of Forensic Medicine and Medicolegal Expertises, Jessenius Faculty of Medicine, Comenius University and University Hospital, Martin, Slovak - - 2014
In forensic assessment, denial and concealment of pregnancy has wide-ranging implications including criminal abortions, extramural deliveries, concealment of birth, newborn infant abandonment or even neonaticide. Clarification of whether a newborn was born alive is the most important factor when evaluating an abandoned neonate or concealment of birth. Other points that ...
Schreiber Richard A RA Division of Pediatric Gastroenterology, Hepatology and Nutrition Department of Pediatrics, University of British Columbia, Vancouver, Canada Child and Family Research Institute, Vancouver, Canada - - 2014
Biliary atresia (BA), a leading cause of paediatric liver failure and liver transplantation, manifests by three weeks of life as jaundice with acholic stools. Poor outcomes due to delayed diagnosis remain a problem worldwide. We evaluated and assessed the cost-effectiveness of methods of introducing a BA Infant Stool Colour Card ...
Thaker Vv V Division of Endocrinology, Boston Children's Hospital, Boston, - - 2014
Context: Iodine is a micronutrient essential for thyroid hormone synthesis. Thyroid hormone is critical for normal neurocognitive development in young infants and even transient hypothyroidism can cause adverse neurodevelopmental outcomes. Both iodine deficiency and excess can cause hypothyroidism. Although iodine-induced hypothyroidism is well recognized in premature infants, full-term neonates have ...
Kucera Jennifer N JN Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA, - - 2014
Although spinal cord tethering is known to be associated with certain clinical syndromes and cutaneous stigmata, its incidence in healthy infants with simple sacral dimples has not been thoroughly evaluated. Our objective was to determine the frequency of tethered cord in otherwise healthy patients with simple sacral dimples. We reviewed ...
Duess Johannes W JW National Children's Research Centre, Our Lady's Children's Hospital, Crumlin, Dublin 12, - - 2014
Intestinal dysmotility in preterm infants has often been attributed to immature enteric nervous system. It is frequently reported that Hirschsprung's disease (HD) is rare in premature infants. The exact prevalence of HD in premature infants is not well documented. The classical signs of HD may often not be identified due ...
Paoletti Gabrielle G University of Pittsburgh School of Medicine, Pittsburgh, PA, - - 2014
Background and Objectives. Chronic, severe iron-deficiency anemia (IDA) in the first years of life increases the risk of irreversibly compromised cognitive, affective, and motor development. While IDA in infants has decreased because of dietary changes (iron-fortified formula and delaying cow's milk), toddlers (13-36 months) are equally vulnerable to the adverse ...
Pullinger M M Norwich Medical School, University of East Anglia, Norwich, Norfolk NR4 7TJ, - - 2014
Congenital Talipes Equinovarus (CTEV) is one of the most common congenital limb deformities. We reviewed the records of infants who had received treatment for structural CTEV between 1 January 2007 and 30 November 2012. This was cross-referenced with the prenatal scans of mothers over a corresponding period of time. We ...
Lee Sun Hee SH Department of Pediatrics, Gachon University Gil Medical Center, Incheon, - - 2014
3-methylcrotonyl-coenzyme A carboxylase (3MCC) deficiency is an autosomal recessive disorder in which leucine catabolism is hampered, leading to increased urinary excretion of 3-methylcrotonylglycine. In addition, 3-hydroxyisovalerylcarnitine levels increase in the blood, and the elevated levels form the basis of neonatal screening. 3MCC deficiency symptoms are variable, ranging from neonatal onset ...
Pogliani Laura L Department of Pediatrics, L. Sacco Hospital, University of Milan, 74 GB Grassi, Milan, IT, 20157, - - 2014
Perinatal stroke is a common cause of neurologic disability. Being clinically under-recognized, its true incidence is not known. Maternal thrombophilia is likely to be a predisposing factor. To date, a general consensus for evaluation of babies born to mothers with genetic thrombotic predisposition is missing. This study was undertaken to ...
Yau Vincent M VM Division of Research, Kaiser Permanente, Oakland, CA, - - 2014
Prenatal and early-life exposures to mercury have been hypothesized to be associated with increased risk of autism spectrum disorders (ASDs). This study investigated the association between ASDs and levels of total mercury measured in maternal serum from mid-pregnancy and infant blood shortly after birth. The study sample was drawn from ...
Zerbo Ousseny - - 2014
Biologic markers of infection and inflammation have been associated with Autism Spectrum Disorders (ASD) but prior studies have largely relied on specimens taken after clinical diagnosis. Research on potential biologic markers early in neurodevelopment is required to evaluate possible causal pathways and screening profiles. To investigate levels of cytokines and ...
Ponce Carolina A CA Biomedical Sciences Institute, University of Chile School of Medicine, Independencia 1027, 8380453 Santiago, - - 2014
The primary infection by Pneumocystis of normal, healthy infants is asymptomatic and goes undiagnosed. Microscopy diagnosis of Pneumocystis was sought in lung impression smears (LIS) from two ~3-month-old infants dying unexpectedly in the community. Pneumocystis nuclei and cysts were identified using Hema-Gurr with subsequent Gomori-Grocott staining in the same spot ...
Purdy I B IB Division of Neonatology, Department of Pediatrics, David Geffen School of Medicine at UCLA, Mattel Children's Hospital, University of California, Los Angeles, Los Angeles, CA, - - 2014
Objective:To identify if the incidence of hypothyroidism in infants with Down syndrome is higher than previous childhood estimates (15%) when examined prior to the standard retesting at 6 months of age.Study design:A retrospective observational cohort study of 122 children with Down syndrome admitted to a university-based birthing hospital between May ...
Lasisi Akeem O AO Department of Otorhinolaryngology, College of Medicine, University of Ibadan, Ibadan, Nigeria. Electronic address: - - 2014
The implementation of Neonatal Hearing Screening (NHS) program is still at the preliminary stage particularly in developing countries despite the burden of permanent congenital and early-onset hearing impairment. There has been an earlier report of NHS in a city in Nigeria, however, this is a report of a preliminary NHS ...
Aarnivala Henri E I HE Department of Pediatrics and Adolescence, Oulu University Hospital, Oulu, Finland; University of Oulu, Oulu, Finland. Electronic address: - - 2014
Deformational plagiocephaly (DP) and torticollis are commonly seen in infants and they often co-occur, but little is known of the prevalence and relationship of these conditions in the immediate newborn period. No previous studies focusing on the relationship between cranial shape and cervical motion in newborns can be found. Determining ...
Wen Jian Guo JG Paediatric Urodynamic Center and Department of Urology, Institute of Clinical Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan Province, - - 2014
The neonatal period is critical in bladder development, encompassing the transition from fetal bladder contractions to voluntary infant urination. The aim of this study was to investigate different voiding parameters between male and female newborn infants. We studied 102 healthy, single birth newborn infants - 54 preterm and 48 full-term ...
Gagliardi Luigi L Department of Woman and Child Health, Ospedale Versilia, Viareggio, Italy; - - 2014
We compared the relative effect of hypertensive disorders of pregnancy and chorioamnionitis on adverse neonatal outcomes in very preterm neonates, and studied whether gestational age (GA) modulates these effects.METHODS: A cohort of neonates 23 to 30 weeks' GA, born in 2008 to 2011 in 82 hospitals adhering to the Italian ...
Gunkel J J Department of Neonatology, University Medical Center Utrecht, PO Box 85090, 3508 AB Utrecht, The Netherlands. Electronic address: - - 2014
Cytomegalovirus (CMV) is the most frequently contracted virus in preterm infants. Postnatal infection is mostly asymptomatic but is sometimes associated with severe disease. To diagnose an infection, urine or saliva samples can be tested for CMV-DNA by real-time polymerase chain reaction (rtPCR). Although the diagnostic accuracy of testing saliva samples ...
Boelke Kristi L KL Department of Neonatology, UnityPoint Health-St. Luke's, 2720 Stone Park Blvd., Sioux City, IA, 51104, - - 2014
Pulse oximetry (POx) screening for critical congenital heart disease (CCHD) in neonates is less effective in identifying aortic arch obstruction than in detecting other forms of CCHD. This study was performed to assess the use of neonatal blood pressure (BP) screening to detect CCHD. A retrospective review of BP and ...
Dorreh Fatemeh F abriz University of Medical Sciences, National Public Health Management Center, Department of Community Medicine, Tabriz, Iran. E-ma-il: - - 2014
Objective: The aim of this study was to investigate the epidemiology of congenital hypothyroidism (CH) among newborns in Markazi Province, Iran. Methods: This cross-sectional study was conducted from 2006 to 2012. Blood samples were taken between 3 to 5 days after birth from the heel. Thyroid stimulating hormone (TSH) was ...
Miller Marijean M MM Department of Ophthalmology, Children's National Medical Center and The George Washington University, Washington, DC; Department of Pediatrics, Children's National Medical Center and The George Washington University, Washington, DC. Electronic address: - - 2014
To characterize the retinopathy of prematurity (ROP) and survival of infants born at gestational age (GA) of 22-25 weeks. This study was a comparative case series for the total set of 78 infants ≤25 GA screened for ROP at a level IV NICU during a 21-month period. Data are presented on infants ...
Muchowski Karen E KE Naval Hospital Camp Pendleton Family Medicine Residency Program, Camp Pendleton, CA, - - 2014
Although neonatal jaundice is common, acute bilirubin encephalopathy and kernicterus (i.e., chronic bilirubin encephalopathy) are rare. Universal screening for neonatal hyperbilirubinemia is controversial. The American Academy of Pediatrics recommends universal screening with bilirubin levels or targeted screening based on risk factors. However, the U.S. Preventive Services Task Force and the ...
Kelly Andrea A The Children's Hospital of Philadelphia, Philadelphia, PA, USA Perelman School of Medicine at University of Pennsylvania, Philadelphia, PA, USA - - 2014
Preterm, low-birth-weight neonates are predisposed to metabolic bone disease (MBD). This survey aimed to assess screening, diagnostic, and treatment practices in U.S. level IIIB/IIIC neonatal intensive care units (NICUs). A 29-question anonymous online survey was e-mailed to American Academy of Pediatrics Perinatal Section members. 338 neonatologists, representing 246 IIIB/IIIC NICUs, ...
Kamrath Clemens C Division of Pediatric Endocrinology and Diabetology, Steroid Research and Mass Spectrometry Unit, Center of Child and Adolescent Medicine, Justus Liebig University, Giessen, Germany. Electronic address: - - 2014
To characterize the urinary steroid metabolome of neonates and infants born either at term or preterm. We retrospectively analyzed urinary steroid hormone metabolites determined by gas chromatography-mass spectrometry of 78 neonates and infants born at term and 83 neonates and infants born preterm (median 34 weeks of gestational age). The ...
Ryckman Kelli K - - 2014
Abstract Thyroid hormones are important regulators of fetal neurodevelopment. Among preterm infants, thyroid stimulating hormone (TSH) is highly variable. Understanding this variability will further improvements in screening for thyroid disorders in preterm infants. We examined 61 maternal and infant clinical and demographic factors for associations with neonatal TSH levels in ...
Carberry Angela E AE Sydney School of Public Health, University of Sydney, Camperdown, Sydney, NSW, Australia, - - 2014
Fetal growth restriction is defined as failure to reach growth potential and considered one of the major complications of pregnancy. These infants are often, although not universally, small for gestational age (SGA). SGA is defined as a weight less than a specified percentile (usually the 10th percentile). Identification of SGA ...
Stoll Claude C Laboratoire de Genetique Medicale, Faculte de Medecine, Strasbourg, France. Electronic address: - - 2014
Infants with congenital anomalies of kidney and urinary tract (CAKUT) often have other associated anomalies. The purpose of this investigation was to assess the prevalence and the types of associated anomalies in CAKUT in a defined population from northeastern France. The associated anomalies in CAKUT were collected in all livebirths, ...
Barkai Galia G Pediatric Infectious Disease Unit, The Edmond and Lily Safra Children's Hospital, Chaim Sheba Medical Center, Israel; Department of Pediatrics, Sackler Faculty of Medicine, Tel Aviv University, Israel. Electronic address: - - 2014
To analyze the results of a neonatal universal screen for congenital cytomegalovirus (CMV) using saliva real-time polymerase chain reaction (rt-PCR). During one year (15/5/2011-15/5/2012), saliva was collected from 9845 infants (97% of 10,137 newborns). Viral DNA was extracted by Magna-Pure LC (Roche) and was tested for the presence of CMV ...
Wiles Jason R JR Perinatal Institute, Division of - - 2014
Medium-chain acyl-coenzyme A dehydrogenase (MCAD) deficiency is the most common disorder of mitochondrial fatty acid oxidation. We report a term male infant who presented at 3 days of age with hypoglycemia, compensated metabolic acidosis, hypocalcemia, and prolonged QTc interval. Pregnancy was complicated by maternal premature atrial contractions and premature ventricular ...
Pelly Lorine L 1- Section of Pediatric Infectious Diseases, Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada 2-Pediatric Infectious Diseases, King Abdulaziz Medical City, Jeddah, Saudi - - 2014
Blastomycosis is a dimorphic fungal infection that can be manifested as pulmonary or extrapulmonary disease. Disease in infants is rare, even in endemic areas. We report a case of severe blastomycosis in a 4 month old infant, as well as details of 2 other cases from our center and a ...
Gold Katherine J KJ University of Michigan, Ann Arbor, - - 2014
Stillbirth and infant death are traumatic events with profound and lasting effects on bereaved families. Mothers with perinatal loss are at high risk for poor mental health, although this has not been well-assessed in a representative epidemiologic cohort. There are also virtually no data on loss among African-American women. The ...
Baxter Jason K JK Thomas Jefferson University, Philadelphia, - - 2014
Although current obstetric practice guidelines suggest cervical length assessment in singletons for preterm birth risk, transvaginal ultrasonography has availability limitations. CerviLenz is a disposable device to measure vaginal cervical length. We sought to determine the threshold CerviLenz measurement with optimal specificity and sensitivity for diagnosis of short cervix by transvaginal ...
Glissmeyer Eric W EW Department of Pediatrics - - 2014
This study compares the performance of urine dipstick alone with urine microscopy and with both tests combined as a screen for urinary tract infection (UTI) in febrile infants aged 1 to 90 days. We queried the Intermountain Healthcare data warehouse to identify febrile infants with urine dipstick, microscopy, and culture ...
Arain Yassar H YH Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine, Lucile Packard Children's Hospital, Stanford, CA, 94304, - - 2014
Extreme hyperbilirubinemia (EHB) caused by neonatal glucose-6-phosphate dehydrogenase (G6PD) deficiency is strongly associated with mortality and long-term neurodevelopmental impairment, yet there are limited national strategies to reduce this burden in South Asia. Current known and predicted prevalence of G6PD deficiency in Afghanistan, Bangladesh, Bhutan, India, Nepal, and Pakistan ranges from ...
Kandasamy Y Y 1] Department of Neonatology, The Townsville Hospital, Douglas, Queensland, Australia [2] Mothers and Babies Research Centre, Hunter Medical Research Institute, John Hunter Hospital, Locked Bag 1, Hunter Region Mail Centre, Newcastle, New South Wales, - - 2014
AimsExogenous human erythropoietin (EPO) artificially synthesised through recombinant DNA technology (rHuEPO) is currently used as a substitute for blood transfusion in preterm and low birth weight neonates. The objective of this study is to determine whether the use of rHuEPO is associated with an increased severity of retinopathy of prematurity ...
Gidlöf Sebastian S Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden2Department of Obstetrics and Gynecology, Karolinska University Hospital, Stockholm, - - 2014
IMPORTANCE Recent reports have questioned the rationale for neonatal screening for congenital adrenal hyperplasia (CAH) owing to low sensitivity in salt-wasting forms and a high rate of recall (ie, a positive finding resulting in a visit to a pediatrician and a second test) in preterm infants. OBJECTIVE To determine the ...
Neuman Gal G The Hospital for Sick Children, Toronto, ON, - - 2014
To report a case of seizure-like symptoms in an infant exposed to bupropion and escitalopram through breastfeeding. A 6.5-month-old female infant, breastfed by a mother treated with bupropion XL 150 mg/d and escitalopram 10 mg/d for depression, presented to our hospital with severe emesis and tonic seizure-like symptoms. The symptoms ...
Denkel Luisa A LA Institute of Hygiene and Environmental Medicine, Charité University Medical Center Berlin, German National Reference Center for the Surveillance of Nosocomial Infections, Hindenburgdamm 27, D-12203 Berlin, - - 2014
This study aimed to determine the prevalence of and risk factors for colonization with extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-E) and methicillin-resistant Staphylococcus aureus (MRSA) in very low birth weight (VLBW; <1500 g) infants and their mothers. This investigation was conducted in the perinatal centre at the Charité Berlin between May 2012 ...
Greene Dina N DN Kaiser Permanente, TPMG Northern California Regional Laboratory, Berkeley, CA. Electronic address: - - 2014
Universal screening of total bilirubin in neonates is endorsed by experts from the American Academy of Pediatrics and is increasingly common. Methodological differences between diazo-based quantitation ("wet" chemistry) and reflectance spectrophotometric quantitation ("dry" chemistry) can lead to unnecessary treatment. A recent recalibration of the only commercially available "dry" chemistry assay ...
Pyhtila Brook M BM Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, 30322, - - 2014
It has been 50 years since the first newborn screening (NBS) test for galactosemia was conducted in Oregon, and almost 10 years since the last US state added galactosemia to their NBS panel. During that time an estimated >2,500 babies with classic galactosemia have been identified by NBS. Most of ...
Wei Daniel D Division of Neonatal Medicine, Department of Pediatrics, Los Angeles County and University of Southern California Medical Center, Los Angeles, Calif., - - 2014
Background: Infants born with birth weights under the 10th percentile for their gestational age are classified as small for gestational age (SGA). TORCH infections are reported to be associated with SGA infants. With the low incidence of infections, screening is likely to be expensive and of low utility. Objective: The ...
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