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Rastogi Maynika V - - 2010
Congenital hypothyroidism (CH) occurs in approximately 1:2,000 to 1:4,000 newborns. The clinical manifestations are often subtle or not present at birth. This likely is due to trans-placental passage of some maternal thyroid hormone, while many infants have some thyroid production of their own. Common symptoms include decreased activity and increased ...
Rovelli Rosanna - - 2010
Evaluation of thyroid function in neonates born from mothers affected by autoimmune thyroiditis in order to define if a precise follow-up is necessary for these children. The influence of maternal thyroid peroxidase antibody (TPOAb) and L-thyroxine therapy during pregnancy on neonatal thyroid function was also investigated. 129 neonates were tested ...
Pell Christopher - - 2010
Building on previous acceptability research undertaken in sub-Saharan Africa this article aims to investigate the acceptability of intermittent preventive treatment of malaria in infants (IPTi) in Papua New Guinea (PNG). A questionnaire was administered to mothers whose infants participated in the randomised placebo controlled trial of IPTi. Mothers whose infants ...
Zabidi A A Faculty of Electrical Engineering, University Teknologi Mara, 40450 Shah Alam, Selangor, - - 2010
This paper presents a new application of the Particle Swarm Optimization (PSO) algorithm to optimize Mel Frequency Cepstrum Coefficients (MFCC) parameters, in order to extract an optimal feature set for diagnosis of hypothyroidism in infants using Multi-Layer Perceptrons (MLP) neural network. MFCC features is influenced by the number of filter ...
Tahirovi? Husref - - 2009
AIM: To evaluate the influence of topical iodine-containing antiseptics on neonatal TSH in full-term infants born by Caesarean section in an iodine sufficient area. POPULATION AND METHODS: Urinary iodide excretion (UIE) was estimated in 86 mothers on the second day after delivery by Caesarean section and their 86 full-term neonates. ...
Zimmermann Michael B - - 2009
Iodine deficiency has multiple adverse effects on growth and development because of inadequate thyroid hormone production. Four methods are generally recommended for assessment of iodine nutrition: urinary iodine concentration, thyroid size, and blood concentrations of thyroid-stimulating hormone and thyroglobulin. Iodine intakes < or = 1 mg/d are well tolerated by ...
Chung Hye Rim - - 2009
CONTEXT: The dietary iodine intake of lactating women has been reported to be high in Korea. OBJECTIVES: The aim of this study was to assess iodine balance and to determine its relationship with thyroid function in preterm infants. DESIGN: Thyroid functions of preterm infants born at 34 wk gestation or ...
Shenoy Ambika - - 2009
A term infant was born with respiratory distress, and subsequent imaging, histopathologic, and hormonal studies confirmed congenital hypothyroidism. This report is intended to alert pediatricians to the possibility of congenital hypothyroidism as a cause of respiratory symptoms of unknown cause in neonates with respiratory distress.
Tajima Toshihiro - - 2009
In Sapporo city of Japan, neonatal screening for congenital hypothyroidism has used the measurement of free thyroxine (T4) and thyroid-stimulating hormone (TSH) in the filter-paper blood spot. This system has enabled us to identify hyperthyroxinemic diseases. Filter papers were collected from neonatal infants born at 4-6 d of age and ...
Hemmati F - - 2009
INTRODUCTION: Previous studies report the spectrum of thyroid function abnormalities in critically-ill neonates. In this study, we evaluated the thyroid status in critically-ill neonates, and determined whether thyroid function abnormalities are more common in sick neonatal infants. METHODS: In a prospective cohort study, 67 critically-ill infants from the Neonatal Intensive ...
Lopez-Espinosa Maria-Jose - - 2010
It has been suggested that prenatal exposure to some organochlorine compounds (OCs) may adversely affect thyroid function and may, therefore, impair neurodevelopment. The main aim of this study was to examine the relationship of cord serum levels of 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane (4,4'-DDT), 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene (4,4'-DDE), β-hexachlorocyclohexane (β-HCH), hexachlorobenzene (HCB), four individual polychlorobiphenyl (PCB) ...
Korada Srinivasa Murthy - - 2010
The UK Newborn Screening Programme Centre recommends that a blood spot thyroid stimulating hormone (TSH) cut-off of 10 mU/l is used to detect congenital hypothyroidism (CHT). As the value used varies from 5 to 10 mU/l, we examined the implications of altering this threshold. Our regional blood spot TSH cut-off ...
Chung Hye Rim - - 2009
To determine the validity of a repeat thyroid function test for preterm infants, and to investigate factors that influence thyroid function of preterm infants, thyroid functions of 105 infants born at <32 weeks' gestational age were evaluated. Initial serum free thyroxine (fT4) and thyrotropin (TSH) levels were measured during the ...
Ahmet Alexandra - - 2009
AIM: To determine if neonates exposed to iodinated contrast media are at risk of hypothyroidism. METHODS: A systematic review was conducted by searching electronic databases (e.g. MEDLINE), contacting experts and scanning reference lists. Studies examining the effects of contrast media on neonatal thyroid function were included. Two reviewers independently screened ...
Hudaoglu Orkide G - - 2009
OBJECTIVE: To determine the effect of iodine containing antiseptics on thyroid function for the first 3 weeks in non-very-low-birth weight preterm and term babies, and to evaluate their thyroid function and behavioral status 7 years later. METHODS: Cohort I (between the years 1997-1998) was studied in 57 preterm (30-35 weeks) ...
Papendieck Patricia - - 2009
Maternal hyperthyroidism implies the risk of thyroid abnormalities in the newborn. We describe retrospectively the clinical presentation, treatment and follow up of 28 children born of hyperthyroid mothers. Patients were subdivided as follows: Group A (neonatal hyperthyroidism) (n=9): born from eight hyperthyroid mothers and one thyroidectomized mother. Children born from ...
Sood Mangla - - 2009
US Preventive Services Task Force recommends universal screening of all newborns for early detection of hearing impairment and early intervention to prevent its effects on normal development and acquisition of language skills. During comparison of universal screening of all newborns versus targeted screening of high risk cases to detect hearing ...
Tierney Kelly - - 2009
Objective Recent studies report an association between maternal thyroid auto-antibodies and preterm birth. None have made the important distinction between spontaneous and iatrogenic preterm birth. We investigated the association between spontaneous preterm birth before 35-week gestation and both thyroid function and auto-antibody status. Design Retrospective nested case-control study, samples retrieved ...
Tahirovic H - - 2009
Neonatal TSH screening has as its main goal the early detection and treatment of permanent sporadic congenital hypothyroidism. At the same time neonatal TSH is one of the indicators for monitoring progress towards eliminating iodine deficiency disorders (IDD). To evaluate the usefulness of neonatal TSH screening data as a monitoring ...
Corbetta Carlo - - 2009
CONTEXT: The guidelines of the National Academy of Clinical Biochemistry advocated the use of low bloodspot TSH (b-TSH) threshold for newborn screening of congenital hypothyroidism (CH). The impact generated by the application of this indication is largely unknown. OBJECTIVE: To determine the impact on CH epidemiology and classification generated by ...
Arai Hirokazu - - 2009
BACKGROUND: Transient hypothyroxinemia is the most common thyroid dysfunction in preterm infants. Hypothalamic-pituitary-thyroid immaturity and non-thyroidal illness contribute to its etiology. The aim of the present study was therefore to determine the relationship between thyroid hormone status and early postnatal steroid therapy in preterm infants. METHODS: A prospective study of ...
Myrelid A - - 2009
AIM: Down syndrome (DS) is frequently associated with thyroid dysfunction. The aim of this study was to investigate the blood concentration of thyrotropin (TSH) observed at neonatal screening of infants with DS and its possible association with development of hypothyroidism during childhood. METHODS: TSH levels from neonatal screening of 73 ...
Aiyer R G - - 2009
Auditory brainstem responses (ABR) were recorded in 30 normal and 60 high-risk neonates with gestational age between 30 and 45 weeks. The normative data of normal group as regard to age, sex and various parameters of ABR were compared with high-risk group. ABR parameters especially wave V and interwave V-I ...
Korada Murthy - - 2009
AIMS: Low birth weight is associated with hypothyroidism and an adverse metabolic profile in later life. Our aim was to examine the relationship between neonatal TSH and birth weight, gestational age and sex. METHODS: We compared blood spot filter paper TSH levels with birth weight, gestational age and sex in ...
Olivieri Antonella - - 2009
All the Italian Centres in charge of screening, diagnosis, and follow-up of infants with congenital hypothyroidism participate in the Italian National Registry of affected infants, which performs the nationwide surveillance of the disease. It was established in 1987 as a program of the Health Ministry and is coordinated by the ...
Kugelman Amir - - 2009
Sick premature infants may display transient hypothyroxinemia secondary to immaturity of the hypothalamic-pituitary axis. Therefore, early screening programs of such infants may be misleading. We present such a case report, with review of the literature and the following suggested recommendations. (1) Screening programs should report thyroid-stimulating hormone (TSH) as well ...
van Wassenaer Aleid G - - 2008
A large number of articles exist on thyroid hormone function and its clinical correlates, but only a few exist on trials with thyroid hormones in premature infants. Most of these trials had clinical short-term endpoints, while only one trial had a long-term neurodevelopmental endpoint. None of the trials reported changes ...
Hong Ting - - 2008
Deficiency of thyroid hormone during critical periods of development can severely damage the nervous system, but the specific effects of thyroid hormones on neuromotor development are less certain. Nonetheless, evidence has accumulated to suggest that thyroid hormone deficiency might be one cause of cerebral palsy (CP). The evidence arises from ...
Fisher Delbert A - - 2008
Continuing advances in the care of premature infants has contributed to the increased survival of very low birth weight premature infants. These infants are characterized by a variety of organ and physiological systems immaturities predisposing to deficiencies of postnatal adaptation and a high prevalence of neonatal morbidities. These morbidities have ...
Ares Susana - - 2008
Iodine is a trace element that is essential for the synthesis of thyroid hormones. The thyroid hormones, thyroxine and 3,5,3'-triiodothyronine, are necessary for adequate growth and development throughout fetal and extrauterine life. The iodine intake of newborns is entirely dependent on the iodine content of breast milk and the formula ...
Oken Emily E Department of Ambulatory Care and Prevention, Harvard Medical School, Boston, Massachusetts 02215, USA. - - 2009
Thyroid hormone is essential for normal brain development. Limited data are available regarding whether thyroid function in neonates influences later cognitive development. Our objective was to study associations of newborn T4 levels with maternal thyroid function and childhood cognition. We studied participants in Project Viva, a cohort study in Massachusetts. ...
Fernandez E F EF Division of Neonatology, Department of Pediatrics, University of New Mexico, Albuquerque, NM 87131, USA. - - 2008
To determine cortisol and adrenocorticotropic hormone (ACTH) responses to critical illness in term and late preterm newborns and examine the relationship of these values to measures of clinical illness, including markers of cardiovascular dysfunction. In this prospective observational study, we measured ACTH, baseline cortisol and ACTH-stimulated cortisol concentrations in mechanically ...
Stagnaro-Green Alex - - 2009
CONTEXT: Preterm delivery is the leading cause of perinatal morbidity and mortality in the United States, and its incidence is increasing. The present manuscript reviews the literature on the relationship of hypothyroidism and/or autoimmune thyroid disease to preterm delivery. EVIDENCE ACQUISITION: A PubMed search was used to identify all relevant ...
Azizi Fereidoun - - 2009
OBJECTIVE: The aim of this review is to explore information available regarding iodine secretion in milk, both mothers and infants iodine nutrition during breastfeeding and to make recommendations for appropriate iodine supplementation during lactation. DESIGN: MEDLINE was queried for studies between 1960 and 2007 that included lactation and breastfeeding with ...
Benvenga Salvatore - - 2008
Premature, very-low-birth-weight female twins were diagnosed with congenital hypothyroidism (CH). Thyroid hormone antibodies (THAb) directed against triiodothyronine (T3) and thyroxine (T4) of both the IgM and IgG class were detected in both twins. At age 10 months, a rise in thyroid stimulating hormone (TSH) occurred in both infants and measurement ...
Siklar Z - - 2009
BACKGROUND: The increasing knowledge indicated that borderline hypothyroidism may cause neurodevelopmental disorders. Borderline compensated congenital hypothyroidism could caused by iodine deficiency or iodine overload. One of the most important etiological factors causing prolonged jaundice in the neonatal period is congenital hypothyroidism. Aimed of this study is to investigate the frequency ...
van Tijn David A - - 2008
The Dutch neonatal congenital hypothyroidism (CH) screening program detects infants with CH of central origin (CH-C). These infants have a high likelihood of multiple pituitary hormone deficiencies. ACTH deficiency especially poses an additional risk for brain damage and may be fatal. Our objective was to evaluate different tools for assessment ...
Gjurkova B - - 2008
Congenital hypothyroidism (CH) is the most common preventable cause of mental retardation. Early diagnosis and treatment are crucial to the prevention of severe intellectual deficit. Neonatal screening in a blood spot from the heel of the newborn between the 2nd and 5th day after birth and determination of thyroid stimulation ...
Mathai Sarah - - 2008
OBJECTIVE: To determine the effectiveness of a novel therapeutic paradigm to treat congenital hypothyroidism (CH) incorporating variable initial doses of L-T4 based on the underlying aetiology and frequent monitoring, up to 2 years of age. DESIGN: Retrospective cohort study. PATIENTS: Infants with primary CH diagnosed by newborn screening. MEASUREMENTS: Treatment ...
Watkins Mark G - - 2008
OBJECTIVE: To report the case of a neonate presenting with nonautoimmune thyrotoxicosis and failure to thrive in whom an activating TSHR mutation was suspected. METHODS: We describe the clinical and laboratory findings in a neonate who presented with nonautoimmune thyrotoxicosis and failure to thrive, including results of DNA analysis of ...
Zhi Keqian - - 2008
OBJECTIVE: Many surgical techniques to manage ranulas have been described in the literature. Ranula of infant patients was rare. Few studies have described the approach toward management in infant patients. METHODS: Eleven infant patients were treated for intraoral ranulas. The methods of treatment included aspiration of mucus, marsupialization and excision ...
Rocchi Marco B L - - 2008
AIM: To study the geographical distribution of high thyroid-stimulating hormone (TSH) level in the Marche region (central Italy). METHODS: Data were drawn from the Register of Neonatal Screening for Congenital Hypothyroidism (CH) of the Marche region (Italy), located at the Child Neuropsychiatry Department of Civil Hospital in Fano (Marche, Italy). ...
Perry Rebecca J - - 2008
We describe an infant inadvertently exposed to radioiodine at 17 weeks gestation. His mother had received 400 MBq of (131)I for hyperthyroidism (total T4 178 nmol/L, thyroid stimulating hormone (TSH) <0.1 mU/L, 4-h (131)I uptake 16%). Following cordocentesis at 27 weeks (free T4 12.7 pmol/L, TSH 35.4 mU/L) intra-amniotic thyroxine ...
Dorey Corine M - - 2008
BACKGROUND: Iodine deficiency in infancy can impair neurocognitive development, but there are few available indicators of iodine intake during this critical period. In many countries, access to newborns in maternity clinics in the first few days after birth is high. If spot urine samples could be collected, reference data for ...
Ogawa Eishin - - 2008
OBJECTIVE: To identify those infants who need a higher starting dose of levothyroxine (l-T4) for early normalization of thyroid-stimulating hormone (TSH) level. STUDY DESIGN: TSH levels at 2 time points (1 to 3 weeks and 3 to 5 weeks) after l-T4 therapy at a starting dose of 8 to 12 ...
Korada M - - 2008
BACKGROUND: Revised UK neonatal screening guidelines recommend that a second blood sample for assay of thyroid stimulating hormone (TSH) be taken when preterm infants reach a postmenstrual age of 36 weeks. OBJECTIVE: To examine the results of a regional screening programme to see whether a rise in TSH concentration was ...
Su Pen-Hua - - 2008
BACKGROUND: Previous studies have reported an increased incidence of thyroid dysfunction in premature/low birth weight infants. The cord blood concentrations of transthyretin (TTR), a thyroid hormone binding protein, have also been found to be decreased in preterm infants. While thyroid hormone concentrations are decreased in sick infants, it is not ...
Kratzsch Juergen - - 2008
During the functional ontogenesis of the thyroid gland an increasing number of transcription factors play fundamental roles in thyroid-cell differentiation, maintenance of the differentiated state, and thyroid-cell proliferation. The early growth and development of the fetal thyroid appears to be generally independent of thyroid-stimulating hormone (TSH). TSH and thyroxine (T4) ...
Ng Sze M - - 2008
BACKGROUND: Infants born at extreme prematurity (below 28 weeks' gestation) are at high risk of developmental disability. A major risk factor for disability is having a low level of thyroid hormone which is recognised to be a frequent phenomenon in these infants. At present it is unclear whether low levels ...
Weiss H-R - - 2008
Surface topography evaluations are prone to technical errors due to postural sway of the patients measured. The technical error of lateral deviation (rms) and surface rotation (rms) may vary between 15 and 20%, while the kyphosis angle (IP-ITL) has a technical error of only 5% (2,5 degrees), which is comparable ...
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