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Spasojević Ivan - - 2012
ABSTRACT: The present review is aimed at elucidating the neonatal 'sepsis redox cycle' - the cascade of inflammatory and redox events involved in the pathogenesis of sepsis in neonates. While adult and neonatal sepses share some common features, there are some substantial differences: higher mortality rates occur in adult sepsis ...
Hornik C P - - 2012
Very-low-birth-weight (VLBW, <1500 g birth weight) infants are at high risk for both early- and late-onset sepsis. Prior studies have observed a predominance of Gram-negative organisms as a cause of early-onset sepsis and Gram-positive organisms as a cause of late-onset sepsis. These reports are limited to large, academic neonatal intensive ...
Stritzke Amélie - - 2012
OBJECTIVES:: The smallest premature neonates often receive blood transfusions early in life. Non-restrictive transfusion policies are linked to deleterious outcomes. Exposure of TPN to ambient light (LE) generates oxidation products associated with haemolysis in vitro. Shielding TPN from light (LP) limits oxidation. Hypothesis: protecting TPN from light decreases haemolysis and ...
Azizia Mallika - - 2012
OBJECTIVES:Preterm neonates are at increased risk of sepsis compared with those born at term. We investigated immune status at birth and early neonatal life in very preterm neonates and its association with short-term outcomes.METHODS:Prospective observational study conducted at a university hospital recruiting 113 preterm neonates (23-32 weeks) and 78 controls. ...
Zhu Guoji - - 2012
Infants are known to be more susceptible to pathogens. This might be due in part to the impaired function of macrophage. In the present study, we observed that macrophages from infant mice produced decreased levels of TNF-α and IL-6, but increased IL-10 after stimulation with toll-like receptor 2 (TLR2) agonist ...
Abbing-Karahagopian Victoria - - 2012
To cite this article: Abbing-Karahagopian V, van der Gugten AC, van der Ent CK, Uiterwaal C, de Jongh M, Oldenwening M, Brunekreef B, Gehring U. Effect of endotoxin and allergens on neonatal lung function and infancy respiratory symptoms and eczema. Pediatric Allergy Immunology 2012: 00. ABSTRACT: Background:  Exposure to endotoxin ...
Ross Danielle S - - 2012
Approximately 2 to 3 out of 1000 infants are born with hearing loss in the United States each year. Pediatric primary care physicians (PCPs) can play an important role in ensuring that infants with hearing loss are identified early and provided appropriate services. In this study, pediatric PCPs were surveyed ...
Lipkind Heather S - - 2012
This study compares school-age outcomes among preterm (PT) (32 0/7-<34 weeks), late PT (LP) (34 0/7-<37 weeks), and full-term (FT) infants to assess cognitive sequelae of LP births. We obtained linked birth and educational data for all nonanomalous singleton infants born 1994 through 1998 in New York City who had ...
Tsai Chin-Han - - 2012
This study was conducted to document the perinatal risk factors associated with early-onset neonatal Escherichia coli sepsis and adverse neonatal outcomes. A case-control study of early-onset E coli sepsis compared with that of non-E coli sepsis was conducted by a retrospective data review of all infants with a diagnosis of ...
Paolucci Michela - - 2012
Neonatal sepsis can be classified into two subtypes depending upon whether the onset of symptoms is before 72 hours of life (early-onset neonatal sepsis-EONS) or later (late-onset neonatal sepsis-LONS). These definitions have contributed greatly to diagnosis and treatment by identifying which microorganisms are likely to be responsible for sepsis during ...
Abdollahi Alireza - - 2012
Neonatal sepsis is a major cause of morbidities and mortalities mostly remarkable in the third world nations.We aimed to assess the value of simultaneous measurement of procalcitonin (PCT) and interleukin-6 (IL-6) in association with high sensitive- C reactive protein(hs-CRP) in prediction of early neonatal sepsis.A follow-up study was performed on ...
Cockfield Christy M - - 2012
Universal newborn hearing screening (UNHS) has been implemented for several decades to screen for congenital hearing loss; however, the lost to follow-up (LFU) rate for newborns with a failed screen is nearly 50%. Many studies have examined risk factors rendering infants susceptible to being LFU, but there are no quality ...
Olusanya B O - - 2012
This brief educational update examines the key recommendations in the new report of the World Health Organisation on newborn and infant hearing screening within the Nigerian context. While acknowledging the goal of universal newborn hearing screening as desirable, the authors highlight the need for all tertiary hospitals in the country ...
Chan Kathy Yuen Yee - - 2012
Necrotizing enterocolitis (NEC) and spontaneous intestinal perforation (SIP) are the most common acute surgical emergencies associated with high morbidity and mortality in preterm infants. We aimed to compare the profiles of immunoregulatory proteins and identify novel mediators in plasma of NEC and SIP infants. We also investigated the expression of ...
Lavezzi Anna M - - 2012
This study expands our understanding of the organization of the human caudal pons, providing a morphologic characterization of the medial superior olivary nucleus (MSO), component of the superior olivary complex (SOC) that plays an important role in the processing of acoustic information. We examined victims of sudden unexplained fetal and ...
Pourarian Shahnaz S Neonatal Research Center, Faculty of medicine, Shiraz University of Medical Sciences, Shiraz, - - 2012
Hearing is essential for humans to communicate with one another. Early diagnosis of hearing loss and intervention in neonates and infants can reduce developmental problems. The aim of the present study was to assess the prevalence of hearing impairment in newborns admitted to a neonatal intensive care unit (NICU) and ...
Amir Lisa H - - 2011
Amir LH, James JP, Kelso G, Moorhead AM. International Journal of Nursing Practice 2011; 17: 541-547 Accreditation of midwife lactation consultants to perform infant tongue-tie release Infants with a tongue-tie or ankyloglossia have a short lingual frenulum, which can lead to problems with breastfeeding: attachment difficulties, nipple pain and damage, ...
Olusanya B O - - 2011
This brief educational update examines the key recommendations in the new report of the World Health Organisation on newborn and infant hearing screening within the Nigerian context. While acknowledging the goal of universal newborn hearing screening as desirable, the authors highlight the need for all tertiary hospitals in the country ...
Biswas Ashok Kumar - - 2012
To identify potential risk factors for hearing loss from the infant with high risk criteria as guided by the Joint Committee on Infant Hearing (JCIH, 2000). 490 infants with age range of 2 days to 6 months who had undergone detailed audiological evaluation during for the period of 3 years at Gauhati Medical ...
Bayhan Gülsüm Iclal - - 2011
Tuberculosis in older children has been well described; however, its description in infants is very limited. There are a few studies of infants with tuberculosis in the literature. In this study from February 2007 to May 2009, cases of infantile tuberculosis investigated retrospectively. Thirteen patients with pulmonary tuberculosis detected. Mean ...
Bardají Azucena - - 2011
There is some consensus that malaria in pregnancy may negatively affect infant's mortality and malaria morbidity, but there is less evidence concerning the factors involved. A total of 1030 Mozambican pregnant women were enrolled in a randomized, placebo-controlled trial of intermittent preventive treatment with sulfadoxine-pyrimethamine, and their infants were followed ...
Trudel Karen - - 2011
To report a case of postnatal, postoperative amiodarone-induced hypothyroidism in an infant with a congenital heart defect. Case report and literature review. Pediatric intensive care unit at a freestanding tertiary care children's hospital. At 7 wks of age, a female infant with a congenital heart defect was confirmed to have ...
Narasimha Aparna - - 2011
Neonates are easily prone for bacterial infection. Diagnosis of neonatal septicemia may be difficult as the early signs of sepsis may be subtle and different at different gestational ages. The present study was undertaken to assess the significance of the hematological scoring system (HSS) for early detection of neonatal sepsis. ...
Hoffmann Johannes J M L - - 2011
Neutrophilic granulocytes express their Fcgamma receptor, also known as the CD64 antigen, predominantly when they are activated. This makes neutrophil CD64 a potential biomarker for infection and sepsis. Indeed there is ample literature on the diagnostic utility of neutrophil CD64 in a variety of diseases. This review summarizes the literature ...
Kobbe Robin - - 2011
Recently, the World Health Organization emphasized the potential benefit of intermittent preventive treatment in infants (IPTi) to control malaria and officially recommended implementation of IPTi with sulfadoxine-pyrimethamine (SP) in areas with moderate and high transmission, where SP resistance is not high. As reported rebound effects make further observation mandatory, we ...
Goldsmit Gustavo S GS Neonatology, Hospital Nacional de Pediatria JP Garrahan, Buenos Aires, - - 2011
The term "euthyroid sick syndrome" (ESS) has been used to describe a pattern of thyroid hormone changes during the course of critical illness in adult patients without thyroid disease, often associated with reduced thyroid hormone secretion. To describe the thyroid hormone profile in full-term newborns critically ill compared with thyroid ...
Williams Fiona - - 2011
This review focuses on neonatal transient hypothyroxinaemia, a condition characterized by temporary postnatal reductions in concentrations of Total T4 or Free T4, with normal or low concentrations of thyroid stimulating hormone (TSH). There is neither an agreed quantitative definition, nor an agreed mode of measurement for the condition. Transient hypothyroxinaemia ...
Kişlal Fatih - - 2010
The objectives of this study were to determine the cord blood thyroid-stimulating hormone (TSH) and free T(4) (FT(4) ) levels in Turkish neonates and to determine whether these variables reveal iodine deficiency. We collected 818 cords from healthy mothers at parturition and measured levels of FT(4) and TSH. We also ...
Andersson Maria - - 2010
If children and pregnant women in the population are iodine sufficient, it is generally assumed infants are also sufficient. But weaning infants may be at risk of iodine deficiency because iodized salt contributes little dietary iodine during this period. To fill this gap, iodine fortification of infant formula milk (IFM) ...
Sarathi H A Vijaya - - 2010
We describe a neonate born to a mother with uncontrolled thyrotoxicosis, who was euthyroid during first week of life and later developed central hypothyroidism.
Kaur Gurjit - - 2010
To establish newborn screening in Indian scenario that could lay a framework for future such initiatives. Three disorders namely, congenital hypothyroidism (CH), congenital adrenal hyperplasia (CAH) and glucose-6-phosphate dehydrogenase deficiency (G-6-PDD) were selected for a preliminary study for newborn screening. Heel-prick blood samples were collected from live-born neonates at 24-48 h ...
Vargová Viola - - 2010
Aim of this study was to compare the thyroidal status of mothers to children with and without congenital malformations (CM). We examined 129 mothers of newborns with CM and 228 mothers without CM. The assessment included particular history, physical examination, thyroid ultrasonography, fT4, TSH, and anti-TPO measurement of mothers and ...
Delahunty Caroline - - 2010
Transient hypothyroxinemia is the commonest thyroid dysfunction of premature infants, and recent studies have found adverse associations with neurodevelopment. The validity of these associations is unclear because the studies adjusted for a differing range of factors likely to influence neurodevelopment. The aim was to describe the association of transient hypothyroxinemia ...
Kazi Tasneem Gul - - 2010
There is accumulating facts that the metabolism of essential trace elements is altered in thyroid patients. The aim of present study was to compare the status of essential trace elements, iodine, iron (Fe), and selenium (Se) in biological samples (serum and urine) of goitrous mothers (age ranged 30-40) and their ...
Mulrine Hannah M - - 2010
Little is known about the iodine status of lactating mothers and their infants during the first 6 mo postpartum or, if deficient, the amount of supplemental iodine required to improve status. The objective was to determine maternal and infant iodine status and the breast-milk iodine concentration (BMIC) over the first ...
Fideleff Gabriel - - 2010
Neonatal reference values for serum thyrotropin are scarce and comprise only small numbers of patients. During 2006, changes were made in IMMULITE kits for TSH measurement. To validate methodological changes, 80 serum samples from patients were evaluated and to establish reference intervals, 334 neonates and infants were analyzed (divided into ...
Remer T - - 2010
Severe iodine deficiency during pregnancy seriously influences fetal brain development and in the worst case induces cretinism. Recent studies have shown that even a mild iodine deficiency during pregnancy and during the first years of life adversely affects brain development. The World Health Organisation (WHO) considers iodine deficiency as the ...
Fusco Francesca Paola - - 2010
We report a case of hypertrabeculated left ventricular myocardium associated with congenital hypothyroidism in a preterm infant. The myocardical anomalies and long QT interval, absent at birth, appeared simultaneously to abnormal thyroid hormones and progressively improved until complete recovery during Levo-Thyroxine treatment. We speculate that thyroid dysfunction could be the ...
Mengreli Chryssanthi - - 2010
CONTEXT: In our neonatal program, a number of infants with congenital hypothyroidism (CH) had escaped diagnosis, when a spot RIA-TSH value of 20 mU/liter whole blood was used as a cutoff point. OBJECTIVE: The objective of the study was to find out prospectively the additional number of newborns with CH ...
Cao Yang - - 2010
Environmental exposure of infants to perchlorate, thiocyanate, nitrate, might interfere with thyroid function. U.S. women with higher background perchlorate exposure have higher thyroid-stimulating hormone (TSH) and lower thyroxine (T4). There are no studies with individual measures of thyroid function and these goitrogens available in infants. We examined the association of ...
Linn Megan - - 2010
We assessed the pattern of levo-thyroxine (l-thyroxine) therapy in very premature newborns over a 10-year period. We analyzed the electronic database of a large private neonatal practice group (Pediatrix, Ft. Lauderdale, FL) for 23- to 32-week gestation neonates ( N = 96,813) managed during 1997 to 2006. L-thyroxine use was analyzed by ...
LaFranchi Stephen H - - 2010
It is the purpose of this article to briefly review the initial development and subsequent evolution of newborn screening programs to detect infants with congenital hypothyroidism (CH) and then to provide an update of the advantages and disadvantages of the main test strategies. Pilot programs began screening newborn populations in ...
Gharehbaghi Manizheh Mostafa - - 2010
Goldenhar syndrome (oculoauriculovertebral dysplasia) is a rare congenital anomaly with unknown etiology and consists of non accidental association of hemifacial microsomia, auricular anomalies, epibulbar dermoid and vertebral anomalies. Although some malformations are more frequent in infants of diabetic mothers, developmental defects of first and second branchial arch is not a ...
Zimmermann Michael B - - 2010
Iodine deficiency (ID) has multiple adverse effects on growth and development due to inadequate thyroid hormone production. Methods for assessment of iodine nutrition in individuals include the urinary iodine concentration (UI), thyroid size and thyroid function tests. The UI measured in several repeat 24-h urine samples can detect inadequate iodine ...
Paul David A - - 2010
BACKGROUND: Transient hypothyroxinemia is common in extremely premature infants, but has not been extensively investigated in ill term and late preterm infants. We hypothesized that free thyroxine (T(4)) levels in term and late preterm infants with respiratory distress would be inversely related to severity of illness METHODS: Eligible infants included ...
Jones Jeremy H - - 2010
BACKGROUND: Thyroid imaging is of proven help in establishing a diagnosis of congenital hypothyroidism in infants. US often shows tissue in the thyroid fossa when radionuclide scintigraphy reveals only ectopic uptake. OBJECTIVE: Our hypothesis was that the use of US alone could lead to the mistaken diagnosis of normal or ...
Hartman T K - - 2010
Each year, malaria threatens 125 million pregnancies, and gestational malaria is responsible for up to 200,000 infant deaths in sub-Saharan Africa. With advancing knowledge of malaria in pregnancy and its impact on newborns, improved preventive and therapeutic interventions are possible. We reviewed and, by consensus, evaluated published literature relevant to ...
Silva S A B - - 2010
BACKGROUND: Neonatal screening for congenital hypothyroidism (CH) in premature infants is not as well established as in term newborns regarding age and number of samples. AIMS: 1. To evaluate the effectiveness of the protocol recommended by the Neonatal Screening Program of the State of Minas Gerais (PETN-MG) for CH neonatal ...
Pearce Mark S - - 2010
Previous studies of congenital hypothyroidism have suggested an increasing incidence and seasonal variation in incidence, which may suggest nongenetic factors involved in aetiology. This study describes the incidence of elevated thyroid stimulating hormone (TSH) values in newborns, a surrogate for congenital hypothyroidism, measured as part of the screening programme for ...
Yagasaki Hideaki - - 2010
Late-onset circulatory dysfunction (LCD) is a phenomenon specific to premature infants and is characterized by sudden onset of hyponatremia, hypotension, oliguria and non-physiological weight gain, without an obvious cause, in premature infants after stabilization of circulation and respiration. The cause of LCD is not clear, but adrenal insufficiency in premature ...
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