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Somers Ronald L - - 2013
Recent US analyses of sudden unexpected infant deaths(1) and accidents associated with infant products(2) do not specifically implicate overly soft sleep surfaces. By contrast, four international studies(3-6) have claimed that overly soft sleep surfaces are strongly associated with fatal sleep accidents. So why the conflicting impressions? (Am J Public Health. ...
Sheets Lynn K - - 2013
OBJECTIVE:Relatively minor abusive injuries can precede severe physical abuse in infants. Our objective was to determine how often abused infants have a previous history of "sentinel" injuries, compared with infants who were not abused.METHODS:Case-control, retrospective study of 401, <12-month-old infants evaluated for abuse in a hospital-based setting and found to ...
van der Aa Niek E - - 2013
Background:Diffusion tensor imaging (DTI) can be used to predict outcome following perinatal arterial ischemic stroke (PAIS), though little is known about white matter changes over time.Methods:Infants with PAIS were serially scanned in the neonatal period (n=15), at 3 months (n=16), and at 24 months (n=8). Fractional anisotropy (FA) values in ...
Infante Smitha K - - 2013
Neonatal hypoxia-ischemia (HI) affects 60% of low birth weight infants and up to 40% of preterm births. Cell death and brain injury after HI have been shown to cause long-lasting behavioral deficits. By using a battery of behavioral tests on second generation 3-week-old rodents, we found that neonatal HI is ...
Xie Ling-Ling - - 2013
To study the characteristics of pediatric arterial ischemic stroke (AIS) and hemorrhagic stroke (HS) in southwest of China, and analyze the etiology and risk factor. This study retrospectively reviewed the records of all patients in both department of neurology and department of neurosurgery in Children's hospital of Chongqing medical university ...
Tamrakar S R SR Department of Obstetrics and Gynaecology, Dhulikhel Hospital - Kathmandu University Hospital, Dhulikhel, Kavre, Nepal. - - 2013
With the advent of ultrasound as a means of providing quality antenatal care, there is an increase in the diagnosis of nuchal cord in fetuses. The major cause of foetal or neonatal death during labor and in postpartum period is birth asphyxia and tight nuchal cord is a cause of ...
Cotton Robert B RB Department of Pediatrics, Vanderbilt University School of Medicine and the Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville, TN 37232, - - 2013
Persistent patency of the ductus arteriosus (PDA) is a common problem in preterm infants. The antacid cimetidine is a potent antagonist of the H2 histamine receptor but it also inhibits certain cytochrome P450 enzymes (CYPs), which may affect DA patency. We examined whether cimetidine contributes to PDA and is mediated ...
Uria-Avellanal Cristina - - 2013
Neonatal seizures are the most common manifestation of neurological disorders in the newborn period and an important determinant of outcome. Overall, for babies born at full term, mortality following seizures has improved in the last decade, typical current mortality rates being 10% (range: 7-16%), down from 33% in reports from ...
Rhee Christopher J - - 2013
New noninvasive methods for monitoring cerebrovascular pressure reactivity coupled with a blood-based assay for brain-specific injury in preterm infants could allow early diagnosis of brain injury and set the stage for improved timing and effectiveness of interventions. Using an adaptation of near-infrared spectroscopy, we report a case of a very ...
Ntuli Sam Thembelihle - - 2013
Accurate and timely information on the causes of child deaths is essential in guiding efforts to improve child survival, by providing data from which health profiles can be constructed and relevant health policies formulated. The purpose of this study was to identify causes of death in children younger than 5 ...
Massaro An N - - 2013
OBJECTIVES:: To determine if candidate biomarkers, ubiquitin carboxyl-terminal esterase L1 and glial fibrillary acidic protein, are elevated in neonates with hypoxic ischemic encephalopathy who die or have severe MRI injury compared with surviving infants with minimal or no injury on brain MRI. DESIGN:: Prospective observational study. SETTING:: Level IIIC outborn ...
Kandasamy Yogavijayan - - 2013
OBJECTIVES:: The incidence of acute kidney injury in neonates is high and associated with up to a 50% mortality rate. The purpose of this review was to determine the feasibility of using serum cystatin C measurements to assist clinicians in making early and accurate diagnoses of acute kidney injury in ...
Beca John - - 2013
BACKGROUND: Abnormalities on magnetic resonance imaging (MRI) scans are common both before and after surgery for congenital heart disease (CHD) in early infancy. The aim of this study was to prospectively investigate the nature, timing and consequences of brain injury on MRI in a cohort of young infants undergoing surgery ...
Schneiderman Megan - - 2013
Abstract Objective: Currently, no ACOG guidelines address the issue of the optimal timing of delivery in placenta previa. Though there is an increased risk of neonatal morbidity and mortality when electively delivered preterm, it is unclear whether adverse neonatal outcomes exist when these pregnancies make it beyond term. By comparing ...
Yildiz Nurdan - - 2013
Abstract Peritoneal dialysis (PD) is considered as the most common form of renal replacement therapy for newborns including preterms with acute kidney injury (AKI). Although there are several reports describing successful PD performed for AKI in preterm infants, there is no data describing the use of PD to treat AKI ...
van der Aa Niek E - - 2013
AIM: To report the clinical presentation, magnetic resonance imaging (MRI) findings, and follow-up data of newborn infants with perinatal arterial ischemic stroke in the territory of the posterior cerebral artery (PCA). METHOD: Data on 18 newborn infants from three neonatal intensive care units (11 males, seven females) with an MRI-confirmed ...
Hummler Stefanie C - - 2013
The pathological hallmarks of bronchopulmonary dysplasia (BPD), a chronic lung disease of premature infants, include inflammation, arrested alveolarization and dysregulated angiogenesis. Severe BPD is often complicated by pulmonary hypertension (PH) that significantly increases morbidity and mortality. Glycogen synthase kinase-3 beta (GSK-3β) plays a pivotal role in embryonic development, cell proliferation ...
Vinall Jillian - - 2013
Slower postnatal growth is an important predictor of adverse neurodevelopmental outcomes in infants born preterm. However, the relationship between postnatal growth and cortical development remains largely unknown. Therefore, we examined the association between neonatal growth and diffusion tensor imaging measures of microstructural cortical development in infants born very preterm. Participants ...
Hazle Matthew A MA Division of Cardiology, Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, - - 2013
To assess the ability of urinary acute kidney injury biomarkers and renal near-infrared spectroscopy (NIRS) to predict outcomes in infants after surgery for congenital heart disease. Urinary levels of neutrophil gelatinase-associated lipocalin (NGAL), interleukin-18 (IL-18), kidney injury molecule-1 (KIM-1), and cystatin C were measured preoperatively and postoperatively in 49 infants ...
Kamar Rita - - 2013
Preterm infants admitted to the Neonatal Intensive Care Unit (NICU) often receive either umbilical- or peripheral arterial lines, for frequent blood sampling and monitoring arterial blood pressure. However, arterial lines can lead to severe complications [1] such as tissue ischemia and as a result necrosis of extremities. The consequences of ...
Finnie J W - - 2013
Traumatic brain injury (TBI) is the major cause of death and severe disability in young adults and infants worldwide and many survivors also have mild to moderate neurological deficits which impair their lives. This review highlights the primary and secondary lesions constituting craniocerebral trauma and the main elements of neuroinflammation, ...
Welaga Paul - - 2013
To determine the neonatal mortality rate in the Kassena-Nankana District (KND) of northern Ghana, and to identify the leading causes and timing of neonatal deaths. The KND falls within the Navrongo Health Research Centre's Health and Demographic Surveillance System (HDSS), which uses trained field workers to gather and update health ...
Marret Stéphane - - 2013
Cerebral palsy (CP), defined as a group of nonprogressive disorders of movement and posture, is the most common cause of severe neurodisability in children. Understanding its physiopathology is crucial to developing some protective strategies. Interruption of oxygen supply to the fetus or brain asphyxia was classically considered to be the ...
Jacobs Allan J - - 2013
Infant circumcision has recently attracted controversy with professional groups recommending it and various individuals trying to criminalize it. Circumcision is beneficial in the prevention of certain diseases, causing minimal tangible harm to those circumcised. This article argues that government should affirmatively adopt policies tolerating minority practices. Such activities should be ...
Rubens Daniel - - 2013
Sudden infant death syndrome (SIDS) is a condition in which an infant, usually in the early postnatal period and nearly always before 6 months of age, dies during sleep for unexplained reasons and the standard autopsy fails to disclose an etiology. Various physiological explanations of risk factors include the prone ...
Brew Nadine - - 2013
Extremely preterm infants often receive mechanical ventilation (MV), which can contribute to bronchopulmonary dysplasia (BPD). However, the effects of MV alone on the extremely preterm lung and the lung's capacity for repair are poorly understood. To characterise lung injury induced by MV alone, and mechanisms of injury and repair, in ...
Barrington Keith J - - 2013
Hemodynamic problems are common in neonatal intensive care. They occur in the context of incomplete myocardial and vascular development and in cardiovascular responses to interventions which are, as a result, limited and often uncertain and unpredictable. In this review, I outline the hemodynamic features of 4 neonatal conditions which often ...
Matić Vladimir - - 2013
In neonatal intensive care units, there is a need for continuous monitoring of sick newborns with perinatal hypoxic ischemic brain injury (HIE). We assessed the utility of heart rate variability (HRV) in newborns with acute HIE undergoing simultaneous continuous EEG (cEEG) and ECG monitoring. HIE was classified using clinical criteria ...
Smyser Christopher D - - 2013
The cerebral white matter is vulnerable to injury in very preterm infants (born prior to 30 weeks gestation), resulting in a spectrum of lesions. These range from severe forms, including cystic periventricular leukomalacia and periventricular hemorrhagic infarction, to minor focal punctate lesions. Moderate to severe white matter injury in preterm ...
Parrish Jared - - 2013
Serious physical abuse resulting in a traumatic brain injury (TBI) has been implicated as an underreported cause of infant mortality. Nearly 80% of all abusive head trauma (AHT) occurs among children <2 years of age, with infants experiencing an incidence nearly 8 times that of 2-year olds. This study describes ...
Pogribna Ulana - - 2013
To identify perinatal clinical antecedents of white matter microstructural abnormalities in extremely preterm infants. A prospective cohort of extremely preterm infants (N = 86) and healthy term controls (N = 16) underwent diffusion tensor imaging (DTI) at term equivalent age. Region of interest-based measures of white matter microstructure - fractional anisotropy and mean diffusivity ...
Thornton Charlene - - 2013
Introduction. Trauma, including suicide, accidental injury, motor traffic accidents, and homicides, accounts for 73% of all maternal deaths (early and late) in NSW annually. Late maternal deaths are underreported and are not as well documented or acknowledged as early deaths. Methods. Linked population datasets from births, hospital admissions, and death ...
John Simon Mathew - - 2013
Abusive head injury is a major contributor to morbidity and mortality in infants and toddlers, but data comparing patterns of injury in corroborated accidental trauma and confessed child abuse are scarce. This is a retrospective review of head injuries with abnormal neuroimaging in children younger than 3 years during a ...
Swanson Jordan W - - 2013
With unprecedented survival rates in modern burn care, there is increasing focus on optimizing long-term functional outcomes. However, 3% to 8% of patients admitted to burn centers still die of injury. Patterns in which these patients progress to death remain poorly characterized. We hypothesized that burn nonsurvivors will follow distinct ...
Smyk Daniel S - - 2013
Background and Aim. Neonatal hemochromatosis (NH) is characterised by severe liver injury and extrahepatic siderosis sparing the reticuloendothelial system. Its aetiology is obscure, although it has been proposed as an alloimmune disease, resulting from immunological reaction to self-antigens (alloantigens) which the body recognizes as foreign. We studied an infant with ...
Jaggat A - - 2013
Birth injuries are devastating to parents and carers alike. They carry the possibility of residual loss of function to the infant and thus the potential for litigation. The aim of this study was to determine the incidence of Erb-Duchenne's palsy and the identification of any contributing factors. A retrospective review ...
Hsiao Marvin M Centre for Global Health Research, Li Ka Shing Knowledge Institute, St Michael's Hospital, University of Toronto, Toronto, - - 2013
To quantify and describe the mechanism of road traffic injury (RTI) deaths in India. We conducted a nationally representative mortality survey where at least two physicians coded each non-medical field staff's verbal autopsy reports. RTI mechanism data were extracted from the narrative section of these reports. 1.1 million homes in ...
Singh Neetu N Department of Pediatrics, Division of Neonatology, Dartmouth Hitchcock Medical Center, 1 Medical Center Drive, Rubin 529, Lebanon, NH 03756, - - 2013
Posthemorrhagic anemia is a rare but important cause of anemia in neonates, second only to hemolytic anemia of newborn. Most cases of posthemorrhagic anemia are reported from fetomaternal hemorrhage or umbilical cord accidents in utero. This case report describes a preterm infant who developed severe anemia and shock immediately after ...
Partridge Robert R Adjunct Associate Professor of Emergency Medicine, Division of International Emergency Medicine, Department of Emergency Medicine, Warren Alpert Medical School of Brown University, Providence, Rhode - - 2013
Objective: To describe the locations and risk of death associated with natural disaster fatalities for US citizens traveling abroad. Design, setting, and participants: A retrospective database review of US citizen disaster deaths occurring worldwide. Interventions: None. Main outcome measures: Information on fatalities due to disasters was abstracted from the US ...
Wisnowski Jessica L JL Department of Radiology, Children's Hospital Los Angeles, Los Angeles, California, - - 2013
Preterm infants (∼10% of all births) are at high-risk for long-term neurodevelopmental disabilities, most often resulting from white matter injury sustained during the neonatal period. Glutamate excitotoxicity is hypothesized to be a key mechanism in the pathogenesis of white matter injury; however, there has been no in vivo demonstration of ...
Chen Hui-Jin - - 2012
BACKGROUND: There is a large number (1.5 million per year) of premature births in China. It is necessary to obtain the authentic incidences of intraventricular hemorrhage (IVH) and periventricular leukomalacia (PVL), the common brain injuries, in Chinese premature infants. The present multicenter study aimed to investigate the incidence of brain ...
Zhang Jun - - 2012
AIMS AND OBJECTIVES: To explore the relationship between perinatal brain injury, visual motor function (VMF) and poor school outcome. BACKGROUND: Little is known about the status and underlying mechanism of poor school outcome as experienced by low birth weight survivors. DESIGN: This is a secondary data analysis. METHODS: The parental ...
Ramanantsoa Nelina - - 2013
The consequences of perinatal brain injury include immeasurable anguish for families and substantial ongoing costs for care and support of effected children. Factors associated with perinatal brain injury in the preterm infant include inflammation and infection, and with increasing gestational age, a higher proportion is related to hypoxic-ischemic events, such ...
Fogel Robert W - - 2012
Making use of those Union Army veterans for whom death certificates are available, we compare the conditions with which they were diagnosed by Civil War pension surgeons to the causes of death on the certificates. We divide the data between those veterans who entered the pension system early because of ...
Eis-Hübinger Anna M - - 2013
Sepsis and sepsis-like illness in neonates and infants are serious emergencies. Recently, human parechovirus type 3 (HPeV-3) has been identified as a further etiologic agent of these conditions. We report two unlinked cases of infant HPeV-3 sepsis-like illness whose sources could be traced back to elder siblings with mild gastroenteritis ...
Raju Tonse N K TN Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 6100 Executive Boulevard, 4B03, Bethesda, MD 20892, USA. - - 2012
This article provides a brief overview of pros and cons of clamping the cord too early (within seconds) after birth. It also highlights evolving data that suggest that delaying cord clamping for 30 to 60 seconds after birth is beneficial to the baby, with no measurable negative effects either the ...
Shankaran Seetha S Neonatal-Perinatal Medicine, Children's Hospital of Michigan, # 4C19, 3901 Beaubien Boulevard, Detroit, MI, 48201, USA, - - 2012
Neonatal Hypoxic-ischemic encephalopathy in full term infants has been associated with a high risk for morbidity and mortality. The patho-physiology of brain injury following hypoxia-ischemia, noted in preclinical models, is a cascade of events resulting from excitotoxic and oxidative injury culminating in cell death. Hypothermia has been noted to be ...
McCann M E ME Department of Anesthesiology, Perioperative and Pain Medicine, Boston Children's Hospital, Boston, MA 02115, - - 2012
Anaesthetic-induced developmental neurotoxicity (AIDN) has been clearly established in laboratory animal models. The possibility of neurotoxicity during uneventful anaesthetic procedures in human neonates or infants has led to serious questions about the safety of paediatric anaesthesia. However, the applicability of animal data to clinical anaesthesia practice remains uncertain. The spectre ...
Ellery Stacey J - - 2012
Background:Acute kidney injury (AKI) is a major complication for infants following an asphyxic insult at birth. We aimed to determine if kidney structure and function were affected in an animal model of birth asphyxia and if maternal dietary creatine supplementation could provide a energy reserve to the fetal kidney, maintaining ...
Lucas-Herald Angela - - 2012
OBJECTIVES:This study aimed to identify the prevalence and characteristics of rib fractures in ex-preterm infants.METHODS:Infants born at <37 weeks' gestation and admitted before 2011 to 3 regional neonatal units were identified from admission registers. For 2 centers, these data were available from 2000 onward and, for another center, from 2005. ...
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