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Blackman James A JA Department of Pediatrics, University of Virginia, Charlottesville, Va., - - 2014
Background: Extremely preterm infants have an increased risk of brain injury and, consequently, are more likely to exhibit signs of motor, cognitive or behavioral impairment. Various factors, including genetic, may influence how the brain responds to an injury, ranging from no to complete recovery. The apolipoprotein E (APOE) gene codes ...
Boyar V V 1] Division of Neonatal-Perinatal Medicine, Department of Pediatrics, New Hyde Park, NY, USA [2] Hofstra North Shore-LIJ School of Medicine, Hempstead, NY, - - 2014
Preterm, critically ill neonates represent a challenge in wound healing. Many factors predispose infants to skin injuries, including decreased epidermal-dermal cohesion, deficient stratum corneum, relatively alkaline pH of skin surface, impaired nutrition and presence of multiple devices on the skin. We present a case series describing the use of medical-grade ...
McDonnell Emily E Pediatric Residency Program, Children's National Medical Center, Washington, - - 2014
To assess risks involved in using wearable blankets, swaddle wraps, and swaddling. This was a retrospective review of incidents reported to the Consumer Product Safety Commission between 2004 and 2012. A total of 36 incidents involving wearable blankets and swaddle wraps were reviewed, including 10 deaths, 2 injuries, and 12 incidents ...
Brown Craig W CW Emergency Department, Royal Aberdeen Children's Hospital, Aberdeen, Scotland, - - 2014
The aim of this study was to describe the aetiology and severity of head injury in an infant (age<1 year) population presenting to a Scottish Paediatric Emergency Department (PED) and to discern preventable risk factors. The records of infants who presented to the PED of the Royal Aberdeen Children's Hospital ...
Pichler Gerhard G Division of Neonatology, Department of Pediatrics, University of Alberta, Edmonton, Alta., - - 2014
Background: The brain is vulnerable to injury and dysfunction during transition after birth in neonates. Clinical assessment of the neurological status immediately following birth is difficult, especially during resuscitation. Objective: Our aim was to review physiological monitoring of the brain during immediate postnatal transition - the first 15 min after ...
Aberg Katarina - - 2014
Very few studies have investigated the neonatal outcomes after vacuum extraction delivery (VE) in the preterm period and the results of these studies are inconclusive. The objective of this study was to describe the use of VE for preterm delivery in Sweden and to compare rates of neonatal complications after ...
Blüml Stefan S Department of Radiology, Children's Hospital Los Angeles, Los Angeles, California, United States of America ; Rudi Schulte Research Institute, Santa Barbara, California, United States of - - 2014
Significant physiological switches occur at birth such as the transition from fetal parallel blood flow to a two-circuit serial system with increased arterial oxygenation of blood delivered to all organs including the brain. In addition, the extra-uterine environment exposes premature infants to a host of stimuli. These events could conceivably ...
de Bruïne Francisca T FT Department of Radiology, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, The Netherlands, - - 2014
Gradient echo T2*-W sequences are more sensitive than T2-W spin-echo sequences for detecting hemorrhages in the brain. The aim of this study is to correlate presence of hemosiderin deposits in the brain of very preterm infants (gestational age <32 weeks) detected by T2*-W gradient echo MRI to white matter injury and ...
Okabe Tetsuhiko T Department of Radiology, Kanagawa Children's Medical Center, 2-138-4 Mutsukawa, Minami-ku, Yokohama, 232-8555, Japan, - - 2014
Knowledge of MRI findings in pediatric cerebral infarction is limited. To determine whether cortical necrosis and network injury appear in the acute phase in post-stroke children and to identify anatomical location of acute network injury and the ages at which these phenomena are seen. Images from 12 children (age range: ...
Mahoney Ashley Darcy - - 2014
There has been substantial research on low birthweight (LBW) as a predictor of adverse educational and cognitive outcomes. LBW infants perform worse on cognitive battery tests compared to children born at normal birthweight; however, children exposed to similar risks do not all share the same experiences. The complex, interrelated factors ...
Maxwell Bryan G BG Department of Anesthesia, The Stanford University School of Medicine, Stanford, CA, - - 2014
Improved survival from congenital heart disease has led to an increasing need for complex reoperation by reentrant sternotomy. Peripheral cannulation and initiation of cardiopulmonary bypass prior to sternotomy to avoid the risk of cardiac injury and massive hemorrhage is an option in adults and larger children, but femoral vessel size ...
Kutsch Jennifer - - 2014
Purpose: Despite the lack of safety data, chlorhexidine gluconate (CHG) is an antiseptic with broadspectrum coverage often used in neonatal intensive care units (NICUs). Adverse skin reactions, most commonly burns, have been reported after the use of CHG. Preserving skin integrity in preterm infants is vital in the prevention of ...
Lally Peter J PJ Perinatal Neurology and Neonatology, Imperial College London, London, United - - 2014
Although brain injury after neonatal encephalopathy has been characterised well in high-income countries, little is known about such injury in low- and middle-income countries. Such injury accounts for an estimated 1 million neonatal deaths per year. We used magnetic resonance (MR) biomarkers to characterise perinatal brain injury, and examined early ...
Samiee-Zafarghandy Samira S Division of Paediatric Clinical Pharmacology, Children's National Medical - - 2014
Peripheral tissue injury is one of the well-described morbidities associated with stays in the neonatal intensive care unit. Despite the potential long-term disability associated with this event, the current available therapeutic options remain very limited. Topical nitroglycerin has emerged as a promising agent for the treatment of tissue injury in ...
Vento G G . - - 2014
Several studies in the lamb model have shown that hyperinflation of the lungs early in life may cause a blunted response to surfactant with signs of lung injury and any attempt to recruit lung volume in the surfactant deficient preterm infant by large lung inflations at birth should be potentially ...
Salmeen Kirsten E KE 513 Parnassus Avenue, Room HSE-1634, Box 0556, San Francisco, CA 94143-0556 - - 2014
Fetal or neonatal brain injury can result in lifelong neurologic disability. The most significant risk factor for perinatal brain injury is prematurity; however, in absolute numbers, full-term infants represent the majority of affected children. Research on strategies to prevent or mitigate the impact of perinatal brain injury ("perinatal neuroprotection") has ...
Rygh Astrid B AB Department of Obstetrics and Gynecology, Stavanger University Hospital, Stavanger, Norway Department of Clinical Medicine I, University of Bergen, Bergen, - - 2014
To assess the association of oxytocin augmentation with obstetric anal sphincter injury among nulliparous women. Population-based, case-control study. Primary and secondary teaching hospital serving a Norwegian region. 15 476 nulliparous women with spontaneous start of labour, single cephalic presentation and gestation ≥37 weeks delivering vaginally between 1999 and 2012. Based on the ...
Balegar Kiran Kumar KK Department of Neonatal Medicine, Women's and Children's Hospital, North Adelaide, SA, - - 2013
To evaluate the relationship between cerebral fractional tissue oxygen extraction (cFTOE), a measure of oxygen delivery-consumption equilibrium, and the risk of early poor outcome in very preterm infants. Cerebral blood flow, tissue oxygenation index (by near-infrared spectroscopy), and arterial oxygen content were measured, and cerebral oxygen delivery, consumption, and cFTOE ...
Salmaso Natalina N Child Study Center, Yale University, 230 South Frontage Road, New Haven, CT 06520, - - 2014
The incidence of preterm birth is on the rise. The outcome of premature birth can vary widely, spanning completely normal development to severe neurologic deficits, with most children showing mild to moderate cognitive delay and increased incidence of neuropsychiatric conditions such as anxiety, attention deficit hyperactivity, and autism spectrum disorders. ...
Tipple Trent E TE The Research Institute at Nationwide Children's Hospital, Center for Perinatal Research, 700 Children's Drive, Columbus, Ohio, United States, 43205, College of Medicine, The Ohio State University, Pediatrics, Columbus, Ohio, United States ; - - 2013
Significance Fetal lung development takes place in hypoxia meaning that premature birth is hyperoxia for the prematurely born infant. The most common respiratory morbidity afflicting premature infants is bronchopulmonary dysplasia (BPD). Pathophysiologically, BPD represents the impact of injury, including O2 toxicity, to the immature developing lung that causes arrested lung ...
Drury Paul P PP Department of Physiology, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland 1023, New - - 2014
Prolonged, moderate cerebral hypothermia initiated within a few hours after severe hypoxia-ischemia and continued until resolution of the acute phase of delayed cell death can reduce acute brain injury and improve long-term behavioral recovery in term infants and in adults after cardiac arrest. The specific mechanisms of hypothermic neuroprotection remain ...
Chau Vann V Division of Neurology, Department of Pediatrics, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, M5G 1X8, Canada; University of Toronto, Department of Pediatrics, 563 Spadina Crescent, Toronto, Ontario, M5S 2J7, Canada; Child & Family Research Institute, 950 28th Avenue, Vancouver, British Columbia, V5Z 4H4, Canada. Electronic address: - - 2014
Chorioamnionitis (or placental infection) is suspected to be a risk factor for brain injury in premature infants. The suggested association between chorioamnionitis and cystic periventricular leukomalacia and cerebral palsy is uncertain because of the variability of study designs and definitions of chorioamnionitis. Improvements in neonatal intensive care may have attenuated ...
Chalak Lina F LF Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX. Electronic address: - - 2014
To evaluate serum neuronal and inflammatory biomarkers to determine whether measurements of umbilical cords at birth can stratify severity of hypoxic-ischemic encephalopathy (HIE), whether serial measurements differ with hypothermia-rewarming, and whether biomarkers correlate with neurological outcomes. This is a prospective cohort of inborn term newborns with varying degrees of HIE ...
Sorokin Yoram Y Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Wayne State University, Detroit, - - 2013
Objective The aim of the study is to determine if umbilical cord serum concentrations of interleukin-6 (IL-6), C-reactive protein (CRP), and myeloperoxidase (MPO), in pregnancies at risk for preterm birth (PTB), are associated with neonatal morbidities and/or altered neurodevelopmental outcomes in the children. Study Design Umbilical cord serum samples were collected at ...
Young-Lin Nichole - - 2013
A 7-month-old boy with glutaric aciduria type 1 (GA1) presented with 1 week of clustered flexor spasms. Examination revealed mild axial hypotonia without encephalopathy. Video-EEG monitoring revealed hypsarrhythmia and infantile spasms (figure, A). MRI showed acute basal ganglia injury (figure, B). After 3 weeks of prednisolone treatment, 5-month follow-up showed ...
Sherry Melissa K - - 2013
Currently, little is known about rates of death by cause and country among US travellers. Understanding the risk by cause and country is imperative to risk communication and the development of risk reduction strategies. Publicly available data on non-natural deaths of US citizens abroad were gathered from January 2003 to ...
Kara Semra - - 2013
Infant walkers are still very popular even though their use might cause injuries. A survey was carried out to obtain information about attitudes and pediatricians' approach regarding the use of infant walkers. Two hundred and forty seven pediatricians who attended the 44th Turkish Congress of Pediatrics and Europediatrics (2008) were ...
Heron Melonie - - 2013
Objectives-This report presents final 2010 data on the 10 leading causes of death in the United States by age, sex, race, and Hispanic origin. Leading causes of infant, neonatal, and postneonatal death are also presented. This report supplements the Division of Vital Statistics' annual report of final mortality statistics. Methods-Data ...
Sousa Nayara Francisca Cabral de NF Departamento de Enfermagem, Centro de Ciências da Saúde, Hospital das Clínicas, Universidade Federal de Pernambuco, Brasil, RecifePE, Enfermeira. Especialista em Saúde da Criança, Programa de Residência, Departamento de Enfermagem , Centro de Ciências da Saúde , Hospital das Clínicas , Universidade Federal de Pernambuco , Recife , PE , Brasil - - 2013
The aim of this study was to investigate the prevalence and factors associated with nasal septum injury in preterm infants in the use of noninvasive ventilation. A cross-sectional study with data collection between March and July 2012 and with search for records, interviews with mothers and nasal evaluation of 47 ...
Wang Ya Lun - - 2013
To evaluate the effect of serious periventricular white matter injury (PWMI) on the voiding patterns of preterm infants. Free voiding was continuously observed for eight hours in 19 preterm infants with serious PWMI and 16 infants without PWMI. The infants had a gestational age of 32 to 35 weeks and ...
Graf Amanda E - - 2013
Maternal inflammation is a risk factor for preterm birth, and premature infants are often exposed to supplemental oxygen as a life-sustaining therapy. While more immature neonates are surviving, rates of neurodevelopmental impairment are not improving. We developed a novel mouse model with clinically relevant exposures to test the hypothesis that ...
Kim Heng Mi - - 2013
Intracranial hemorrhage (ICH) is rare birth injury in term infants. However, newborn infants with a cephalohematoma (CH) associated with an ICH have frequently been found incidentally at our hospital; many of them had no neurological symptoms. The aim of this study was to evaluate the clinical manifestations of ICH in ...
Lundberg Camilla - - 2013
The timing and practice used for umbilical cord clamping of neonates are controversial internationally as well as in Norway. We therefore wished to investigate routines and practices for umbilical cord clamping of neonates in Norway. A web-based questionnaire was sent to heads of departments of all maternity wards in Norway ...
Hehir Mark P - - 2013
We sought to compare maternal and neonatal outcomes in deliveries occurring overnight with those in daylight hours. Prospective observational study. Large national tertiary referral center. All singleton laboring nulliparous parturients delivering infants >500g over a 2 - year period, January 1(st) 2008 - December 31(st) 2009. Details of intrapartum characteristics ...
Rozance Paul J - - 2013
Neonatal hypoglycemia is one of the most common biochemical abnormalities encountered in the newborn. However, controversy remains surrounding its definition and management especially in asymptomatic patients. New information has been published that describes the incidence and timing of low glucose concentrations in the groups most at risk for asymptomatic neonatal ...
Yoo Ji Young Janice - - 2013
Recent studies have shown that hemorrhagic injury in the preterm cerebellum leads to long-term neurological sequelae, such as motor, affective, and cognitive dysfunction. How cerebellar hemorrhage (CBH) affects the development and function of the cerebellum is largely unknown. Our study focuses on developing a mouse model of CBH to determine ...
Saugstad Ola Didrik - - 2013
Background: The optimal oxygen saturation for extremely low birth weight infants in the postnatal period beyond the delivery room is not known. Objectives: To summarize and discuss the results of the randomized trials, constituting the NEOPROM (Neonatal Oxygenation Prospective Meta-analysis) collaborative study, examining the effect of low versus high functional ...
Schang Anne-Laure - - 2013
Preterm birth is very strongly associated with maternal/foetal inflammation and leads to permanent neurological deficits that correlate with white matter injury, including maturational arrest of oligodendrocytes and hypomyelination. Preterm birth and exposure to inflammation causes hypothyroxinemia. As such, supplementation with thyroxine (T4) seems a good candidate therapy for reducing white ...
Sadarangani Sapna P - - 2013
Brain abscesses in neonates are typically caused by Gram negative organisms. There are no previously described cases caused by Clostridium septicum. We present a case of a premature male infant who developed recurrent episodes of suspected necrotizing enterocolitis followed by brain abscesses, cerebritis and ventriculitis caused by Clostridium septicum.
de Vries Linda S - - 2013
Since the introduction of neonatal intensive care in the 1970s, there has been a pronounced decrease in overall mortality of premature infants as well as a decrease in the incidence of severe white matter injury, best known as cystic periventricular leukomalacia (c-PVL).(1) While cranial ultrasonography readily visualizes large lesions in ...
Chau Vann V From the Departments of Pediatrics (S.P.M.), Divisions of Neurology (V.C.) and Neonatology (A.S., R.E.G.), Radiology (K.J.P.), and Statistics (R.B.), BC Children's & Women's Hospitals and University of British Columbia, and the Child & Family Research Institute (V.C., A.S., R.E.G., K.J.P., R.B., S.P.M.), Vancouver; and Department of Pediatrics (S.P.M., V.C.), Neurology, the Hospital for Sick Children and University of Toronto, - - 2013
Our objective was to determine the association of early brain maturation with neurodevelopmental outcome in premature neonates. Neonates born between 24 and 32 weeks' gestation (April 2006 to August 2010) were prospectively studied with MRI early in life and again at term-equivalent age. Using diffusion tensor imaging and magnetic resonance ...
Sarginson Julia H - - 2013
Hair straighteners have become a popular and common household appliance. The incidence of burns from these devices is rising, and is of particular concern given that the main casualties are infants. We present the largest case series in the literature of paediatric burns from hair straightening devices. Retrospective data collection ...
Mallard Carina C Department of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, - - 2013
Cerebral palsy is one of the most devastating consequences of brain injury around the time of birth, and nearly a third of cases are now associated with premature birth. Compared with term babies, preterm babies have an increased incidence of complications that may increase the risk of disability, such as ...
Kumar S - - 2013
The main aim of this study was to determine the causes and epidemiological aspects of unnatural deaths in the elderly. Data were collected on 4405 male and female victims of unnatural deaths aged 50 years or more from the total number of 21,235 autopsies performed in King George's Medical University, ...
Soraisham Amuchou Singh AS Department of Paediatrics, University of Calgary, Alberta Children's Hospital Research Institute for Child and Maternal Health, Foothills Medical Centre, 1403, 29(th) Street NW Calgary, AB T2 N 2T9, Canada. Electronic address: - - 2013
To examine the neonatal mortality and morbidity of infants born at < 33 weeks gestational age (GA) who received extensive delivery room cardiopulmonary resuscitation (DR-CPR) immediately after birth. Design/Methods: In this retrospective cohort study, we performed secondary analyses of data from infants born at < 33 weeks GA and admitted ...
Lankarani Kamran B - - 2013
Road traffic crashes are the third highest cause of mortality in Iran. The aim of this study was to determine the impact of roadway environmental factors on traffic crash. This cross-sectional study was conducted in Iran between March 21, 2010 and December 30, 2010. The data on road traffic crashes ...
Stewart Camille L CL University of Colorado, Denver, CO, USA; Children's Hospital Colorado, Aurora, CO, USA. Electronic address: - - 2014
We observed a high incidence of traumatic brain injuries (TBI) in properly restrained infants involved in higher speed motor vehicle crashes (MVCs). We hypothesized that car safety seats are inadequately protecting infants from TBI. We retrospectively queried scene crash data from our State Department of Transportation (2007-2011) and State Department ...
Uche E O - - 2013
Neonatal head trauma resulting from causes other than birth trauma has rarely been the focus of many a research theme in the literature. To highlight the occurrence of non-birth trauma related neonatal head injury, and evaluate the causes and outcome of treatment. A 3 year retrospective review of neonatal patients ...
Carvalho Clarissa Gutierrez CG Hospital de Clínicas de Porto Alegre, Unidade de Terapia Intensiva Neonatal, Porto AlegreRS, Brasil, Unidade de Terapia Intensiva Neonatal, Hospital de Clínicas de Porto Alegre - HCPA - Porto Alegre (RS), - - 2013
In preterm infants, the need for intubation and mechanical ventilation is associated with ventilator-induced lung injuries and subsequent bronchopulmonary dysplasia. The aim of the present review was to improve the understanding of the mechanisms of injury that involve cytokine-mediated inflammation to contribute to the development of new preventive strategies. Relevant ...
Mahoney Ashley Darcy - - 2013
Even when it is just a few weeks before term gestation, early birth has consequences, resulting in higher morbidity and mortality. Respiratory issues related to moderate prematurity include delayed neonatal transition to air breathing, respiratory distress resulting from delayed fluid clearance (transient tachypnea of the newborn), surfactant deficiency (respiratory distress ...
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