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Andropoulos Dean B DB Department of Anesthesiology, Baylor College of Medicine, Houston, TX, USA; Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA; Pediatric Cardiovascular Anesthesiology, Texas Children's Hospital, Houston, TX, - - 2014
Adverse neurodevelopmental outcomes are observed in up to 50% of infants after complex cardiac surgery. We sought to determine the association of perioperative anesthetic exposure with neurodevelopmental outcomes at age 12 months in neonates undergoing complex cardiac surgery and to determine the effect of brain injury determined by magnetic resonance imaging ...
Malaeb Shadi N SN Department of Pediatrics, St. Christopher's Hospital for Children, Drexel University College of Medicine, 245 North 15th Street, New College Building, Room 7410, Mail Stop 1029, Philadelphia, PA 19102, USA. Electronic address: - - 2014
Deleterious effects result from both glucocorticoid insufficiency and excess glucocorticoid tissue exposure in the developing brain. Accumulating evidence suggests a net benefit of postnatal glucocorticoid therapy when administered shortly after the first week of life to premature infants with early and persistent pulmonary dysfunction, particularly in those with evidence of ...
van Heijst Arno F J AF Department of Pediatrics, Division of Neonatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. Electronic address: - - 2014
Extracorporeal membrane oxygenation (ECMO) is a rescue therapy for newborns with severe but reversible respiratory failure. Although ECMO has significantly improved survival, it is associated with substantial complications, of which intracranial injuries are the most important. These injuries consist of hemorrhagic and non-hemorrhagic, ischemic lesions. Different from the classical presentation ...
Wenckus Dj D Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Illinois at Chicago, Chicago, IL, - - 2014
To compare maternal and neonatal outcomes in twins undergoing a trial of labor versus pre-labor caesarean. Retrospective cohort study. 19 US hospitals from the Consortium on Safe Labor. Of 2225 twin sets ≥36 weeks' gestation. Maternal (abruption, estimated blood loss, postpartum haemorrhage, transfusion, chorioamnionitis, hysterectomy, ICU admission, death) and neonatal outcomes ...
Pekcevik Yeliz Y Izmir Tepecik Training and Research Hospital, Radiology Clinic, Gaziler Cd. No. 468, Yenişehir TR-35110, Izmir, - - 2014
Survival rates of extremely preterm infants have risen dramatically, paralleling improvements in prenatal and neonatal care. Cranial sonography is the primary imaging technique for the evaluation of brain injury in these patients. Extremely preterm infants have some unique features related to ongoing maturation, and associated findings on cranial sonography should ...
Dempsey E M EM Department of Paediatrics and Child Health, Neonatal Intensive Care Unit, University College Cork, Wilton, Cork, - - 2014
Background: Extremely preterm babies (delivered at <28 completed weeks of gestation) are frequently diagnosed with hypotension and treated with inotropic and pressor drugs in the immediate postnatal period. Dopamine is the most commonly used first-line drug. Babies who are treated for hypotension more frequently sustain brain injury, have long-term disability ...
Counsell Serena J SJ Division of Imaging Sciences & Biomedical Engineering, Centre for the Developing Brain, King's College London, - - 2014
This review highlights recent work using advanced imaging approaches that have improved our understanding of the underlying neural mechanisms associated with disrupted brain development or demonstrated the potential of MRI to provide objective biomarkers of cerebral injury that relate to subsequent neurodevelopmental performance. Preterm birth impacts on the development of ...
Pogledic Ivana I Inserm U676, Paris; Croatian Institute for Brain Research, Medical School, University of Zagreb, - - 2014
Studies of periventricular white matter injury (PWMI) in preterm infants suggest the involvement of the transient cortical subplate zone. We studied the cortical wall of noncystic and cystic PWMI cases and controls. Non-cystic PWMI corresponded to diffuse white matter lesions, the predominant injury currently detected by imaging. Glial cell populations ...
Messier Amber M AM Division of Neonatology, Department of Pediatrics, University of New Mexico, Albuquerque, New Mexico, - - 2014
The use of erythropoiesis-stimulating agents (ESAs) such as erythropoietin and darbepoetin in preterm and term infants has been studied for over 20 years. Recent investigations have explored the potential neuroprotective effects of ESAs. We review the recent clinical trials and experimental animal models that provide evidence in support of using ...
McDonnell Emily E Pediatric Residency Program, Children's National Medical Center, Washington, - - 2014
To assess risks involved in using wearable blankets, swaddle wraps, and swaddling. This was a retrospective review of incidents reported to the Consumer Product Safety Commission between 2004 and 2012. A total of 36 incidents involving wearable blankets and swaddle wraps were reviewed, including 10 deaths, 2 injuries, and 12 ...
Blackman James A JA Department of Pediatrics, University of Virginia, Charlottesville, Va., - - 2014
Background: Extremely preterm infants have an increased risk of brain injury and, consequently, are more likely to exhibit signs of motor, cognitive or behavioral impairment. Various factors, including genetic, may influence how the brain responds to an injury, ranging from no to complete recovery. The apolipoprotein E (APOE) gene codes ...
Boyar V V 1] Division of Neonatal-Perinatal Medicine, Department of Pediatrics, New Hyde Park, NY, USA [2] Hofstra North Shore-LIJ School of Medicine, Hempstead, NY, - - 2014
Preterm, critically ill neonates represent a challenge in wound healing. Many factors predispose infants to skin injuries, including decreased epidermal-dermal cohesion, deficient stratum corneum, relatively alkaline pH of skin surface, impaired nutrition and presence of multiple devices on the skin. We present a case series describing the use of medical-grade ...
Brown Craig W CW Emergency Department, Royal Aberdeen Children's Hospital, Aberdeen, Scotland, - - 2014
The aim of this study was to describe the aetiology and severity of head injury in an infant (age<1 year) population presenting to a Scottish Paediatric Emergency Department (PED) and to discern preventable risk factors. The records of infants who presented to the PED of the Royal Aberdeen Children's Hospital ...
Pichler Gerhard G Division of Neonatology, Department of Pediatrics, University of Alberta, Edmonton, Alta., - - 2014
Background: The brain is vulnerable to injury and dysfunction during transition after birth in neonates. Clinical assessment of the neurological status immediately following birth is difficult, especially during resuscitation. Objective: Our aim was to review physiological monitoring of the brain during immediate postnatal transition - the first 15 min after ...
Aberg Katarina - - 2014
Very few studies have investigated the neonatal outcomes after vacuum extraction delivery (VE) in the preterm period and the results of these studies are inconclusive. The objective of this study was to describe the use of VE for preterm delivery in Sweden and to compare rates of neonatal complications after ...
Blüml Stefan S Department of Radiology, Children's Hospital Los Angeles, Los Angeles, California, United States of America ; Rudi Schulte Research Institute, Santa Barbara, California, United States of - - 2014
Significant physiological switches occur at birth such as the transition from fetal parallel blood flow to a two-circuit serial system with increased arterial oxygenation of blood delivered to all organs including the brain. In addition, the extra-uterine environment exposes premature infants to a host of stimuli. These events could conceivably ...
de Bruïne Francisca T FT Department of Radiology, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, The Netherlands, - - 2014
Gradient echo T2*-W sequences are more sensitive than T2-W spin-echo sequences for detecting hemorrhages in the brain. The aim of this study is to correlate presence of hemosiderin deposits in the brain of very preterm infants (gestational age <32 weeks) detected by T2*-W gradient echo MRI to white matter injury and ...
Okabe Tetsuhiko T Department of Radiology, Kanagawa Children's Medical Center, 2-138-4 Mutsukawa, Minami-ku, Yokohama, 232-8555, Japan, - - 2014
Knowledge of MRI findings in pediatric cerebral infarction is limited. To determine whether cortical necrosis and network injury appear in the acute phase in post-stroke children and to identify anatomical location of acute network injury and the ages at which these phenomena are seen. Images from 12 children (age range: ...
Mahoney Ashley Darcy - - 2014
There has been substantial research on low birthweight (LBW) as a predictor of adverse educational and cognitive outcomes. LBW infants perform worse on cognitive battery tests compared to children born at normal birthweight; however, children exposed to similar risks do not all share the same experiences. The complex, interrelated factors ...
Maxwell Bryan G BG Department of Anesthesia, The Stanford University School of Medicine, Stanford, CA, - - 2014
Improved survival from congenital heart disease has led to an increasing need for complex reoperation by reentrant sternotomy. Peripheral cannulation and initiation of cardiopulmonary bypass prior to sternotomy to avoid the risk of cardiac injury and massive hemorrhage is an option in adults and larger children, but femoral vessel size ...
Kutsch Jennifer - - 2014
Purpose: Despite the lack of safety data, chlorhexidine gluconate (CHG) is an antiseptic with broadspectrum coverage often used in neonatal intensive care units (NICUs). Adverse skin reactions, most commonly burns, have been reported after the use of CHG. Preserving skin integrity in preterm infants is vital in the prevention of ...
Lally Peter J PJ Perinatal Neurology and Neonatology, Imperial College London, London, United - - 2014
Although brain injury after neonatal encephalopathy has been characterised well in high-income countries, little is known about such injury in low- and middle-income countries. Such injury accounts for an estimated 1 million neonatal deaths per year. We used magnetic resonance (MR) biomarkers to characterise perinatal brain injury, and examined early ...
Samiee-Zafarghandy Samira S Division of Paediatric Clinical Pharmacology, Children's National Medical - - 2014
Peripheral tissue injury is one of the well-described morbidities associated with stays in the neonatal intensive care unit. Despite the potential long-term disability associated with this event, the current available therapeutic options remain very limited. Topical nitroglycerin has emerged as a promising agent for the treatment of tissue injury in ...
Vento G G . - - 2014
Several studies in the lamb model have shown that hyperinflation of the lungs early in life may cause a blunted response to surfactant with signs of lung injury and any attempt to recruit lung volume in the surfactant deficient preterm infant by large lung inflations at birth should be potentially ...
Salmeen Kirsten E KE 513 Parnassus Avenue, Room HSE-1634, Box 0556, San Francisco, CA 94143-0556 - - 2014
Fetal or neonatal brain injury can result in lifelong neurologic disability. The most significant risk factor for perinatal brain injury is prematurity; however, in absolute numbers, full-term infants represent the majority of affected children. Research on strategies to prevent or mitigate the impact of perinatal brain injury ("perinatal neuroprotection") has ...
Mistry Kirtida K Children's National Medical Center, 111 Michigan Ave NW, WW 1.5, Suite 100, Washington, DC 20010, - - 2014
Survival of critically ill neonates in the intensive care unit has improved over the past decades reflecting improvements in obstetric, delivery room and neonatal intensive care, however, morbidity remains significant. Acute kidney injury is a common occurrence in these neonates and despite improved understanding of the pathophysiology and management of ...
Rygh Astrid B AB Department of Obstetrics and Gynecology, Stavanger University Hospital, Stavanger, Norway Department of Clinical Medicine I, University of Bergen, Bergen, - - 2014
To assess the association of oxytocin augmentation with obstetric anal sphincter injury among nulliparous women. Population-based, case-control study. Primary and secondary teaching hospital serving a Norwegian region. 15 476 nulliparous women with spontaneous start of labour, single cephalic presentation and gestation ≥37 weeks delivering vaginally between 1999 and 2012. Based on the ...
Balegar Kiran Kumar KK Department of Neonatal Medicine, Women's and Children's Hospital, North Adelaide, SA, - - 2013
To evaluate the relationship between cerebral fractional tissue oxygen extraction (cFTOE), a measure of oxygen delivery-consumption equilibrium, and the risk of early poor outcome in very preterm infants. Cerebral blood flow, tissue oxygenation index (by near-infrared spectroscopy), and arterial oxygen content were measured, and cerebral oxygen delivery, consumption, and cFTOE ...
Hehir Mark P MP National Maternity Hospital, Dublin, - - 2014
We sought to compare maternal and neonatal outcomes in deliveries occurring overnight with those in daylight hours. Prospective observational study. Large national tertiary referral center. All singleton laboring nulliparous parturients delivering infants >500 g over a 2-year period, 1 January 2008 to 31 December 2009. Details of intrapartum characteristics and ...
Salmaso Natalina N Child Study Center, Yale University, 230 South Frontage Road, New Haven, CT 06520, - - 2014
The incidence of preterm birth is on the rise. The outcome of premature birth can vary widely, spanning completely normal development to severe neurologic deficits, with most children showing mild to moderate cognitive delay and increased incidence of neuropsychiatric conditions such as anxiety, attention deficit hyperactivity, and autism spectrum disorders. ...
Tipple Trent E TE The Research Institute at Nationwide Children's Hospital, Center for Perinatal Research, 700 Children's Drive, Columbus, Ohio, United States, 43205, College of Medicine, The Ohio State University, Pediatrics, Columbus, Ohio, United States ; - - 2013
Significance Fetal lung development takes place in hypoxia meaning that premature birth is hyperoxia for the prematurely born infant. The most common respiratory morbidity afflicting premature infants is bronchopulmonary dysplasia (BPD). Pathophysiologically, BPD represents the impact of injury, including O2 toxicity, to the immature developing lung that causes arrested lung ...
Drury Paul P PP Department of Physiology, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland 1023, New - - 2014
Prolonged, moderate cerebral hypothermia initiated within a few hours after severe hypoxia-ischemia and continued until resolution of the acute phase of delayed cell death can reduce acute brain injury and improve long-term behavioral recovery in term infants and in adults after cardiac arrest. The specific mechanisms of hypothermic neuroprotection remain ...
Chau Vann V Division of Neurology, Department of Pediatrics, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, M5G 1X8, Canada; University of Toronto, Department of Pediatrics, 563 Spadina Crescent, Toronto, Ontario, M5S 2J7, Canada; Child & Family Research Institute, 950 28th Avenue, Vancouver, British Columbia, V5Z 4H4, Canada. Electronic address: - - 2014
Chorioamnionitis (or placental infection) is suspected to be a risk factor for brain injury in premature infants. The suggested association between chorioamnionitis and cystic periventricular leukomalacia and cerebral palsy is uncertain because of the variability of study designs and definitions of chorioamnionitis. Improvements in neonatal intensive care may have attenuated ...
Chalak Lina F LF Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX. Electronic address: - - 2014
To evaluate serum neuronal and inflammatory biomarkers to determine whether measurements of umbilical cords at birth can stratify severity of hypoxic-ischemic encephalopathy (HIE), whether serial measurements differ with hypothermia-rewarming, and whether biomarkers correlate with neurological outcomes. This is a prospective cohort of inborn term newborns with varying degrees of HIE ...
Sorokin Yoram Y Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Wayne State University, Detroit, - - 2013
Objective The aim of the study is to determine if umbilical cord serum concentrations of interleukin-6 (IL-6), C-reactive protein (CRP), and myeloperoxidase (MPO), in pregnancies at risk for preterm birth (PTB), are associated with neonatal morbidities and/or altered neurodevelopmental outcomes in the children. Study Design Umbilical cord serum samples were collected at ...
Young-Lin Nichole - - 2013
A 7-month-old boy with glutaric aciduria type 1 (GA1) presented with 1 week of clustered flexor spasms. Examination revealed mild axial hypotonia without encephalopathy. Video-EEG monitoring revealed hypsarrhythmia and infantile spasms (figure, A). MRI showed acute basal ganglia injury (figure, B). After 3 weeks of prednisolone treatment, 5-month follow-up showed ...
Sherry Melissa K - - 2013
Currently, little is known about rates of death by cause and country among US travellers. Understanding the risk by cause and country is imperative to risk communication and the development of risk reduction strategies. Publicly available data on non-natural deaths of US citizens abroad were gathered from January 2003 to ...
Kara Semra - - 2013
Infant walkers are still very popular even though their use might cause injuries. A survey was carried out to obtain information about attitudes and pediatricians' approach regarding the use of infant walkers. Two hundred and forty seven pediatricians who attended the 44th Turkish Congress of Pediatrics and Europediatrics (2008) were ...
Heron Melonie - - 2013
Objectives-This report presents final 2010 data on the 10 leading causes of death in the United States by age, sex, race, and Hispanic origin. Leading causes of infant, neonatal, and postneonatal death are also presented. This report supplements the Division of Vital Statistics' annual report of final mortality statistics. Methods-Data ...
Sousa Nayara Francisca Cabral de NF Departamento de Enfermagem, Centro de Ciências da Saúde, Hospital das Clínicas, Universidade Federal de Pernambuco, Brasil, RecifePE, Enfermeira. Especialista em Saúde da Criança, Programa de Residência, Departamento de Enfermagem , Centro de Ciências da Saúde , Hospital das Clínicas , Universidade Federal de Pernambuco , Recife , PE , Brasil - - 2013
The aim of this study was to investigate the prevalence and factors associated with nasal septum injury in preterm infants in the use of noninvasive ventilation. A cross-sectional study with data collection between March and July 2012 and with search for records, interviews with mothers and nasal evaluation of 47 ...
Wang Ya Lun - - 2013
To evaluate the effect of serious periventricular white matter injury (PWMI) on the voiding patterns of preterm infants. Free voiding was continuously observed for eight hours in 19 preterm infants with serious PWMI and 16 infants without PWMI. The infants had a gestational age of 32 to 35 weeks and ...
Graf Amanda E - - 2013
Maternal inflammation is a risk factor for preterm birth, and premature infants are often exposed to supplemental oxygen as a life-sustaining therapy. While more immature neonates are surviving, rates of neurodevelopmental impairment are not improving. We developed a novel mouse model with clinically relevant exposures to test the hypothesis that ...
Kim Heng Mi - - 2013
Intracranial hemorrhage (ICH) is rare birth injury in term infants. However, newborn infants with a cephalohematoma (CH) associated with an ICH have frequently been found incidentally at our hospital; many of them had no neurological symptoms. The aim of this study was to evaluate the clinical manifestations of ICH in ...
Lundberg Camilla - - 2013
The timing and practice used for umbilical cord clamping of neonates are controversial internationally as well as in Norway. We therefore wished to investigate routines and practices for umbilical cord clamping of neonates in Norway. A web-based questionnaire was sent to heads of departments of all maternity wards in Norway ...
Rozance Paul J - - 2013
Neonatal hypoglycemia is one of the most common biochemical abnormalities encountered in the newborn. However, controversy remains surrounding its definition and management especially in asymptomatic patients. New information has been published that describes the incidence and timing of low glucose concentrations in the groups most at risk for asymptomatic neonatal ...
Yoo Ji Young Janice - - 2013
Recent studies have shown that hemorrhagic injury in the preterm cerebellum leads to long-term neurological sequelae, such as motor, affective, and cognitive dysfunction. How cerebellar hemorrhage (CBH) affects the development and function of the cerebellum is largely unknown. Our study focuses on developing a mouse model of CBH to determine ...
Saugstad Ola Didrik - - 2013
Background: The optimal oxygen saturation for extremely low birth weight infants in the postnatal period beyond the delivery room is not known. Objectives: To summarize and discuss the results of the randomized trials, constituting the NEOPROM (Neonatal Oxygenation Prospective Meta-analysis) collaborative study, examining the effect of low versus high functional ...
Schang Anne-Laure - - 2013
Preterm birth is very strongly associated with maternal/foetal inflammation and leads to permanent neurological deficits that correlate with white matter injury, including maturational arrest of oligodendrocytes and hypomyelination. Preterm birth and exposure to inflammation causes hypothyroxinemia. As such, supplementation with thyroxine (T4) seems a good candidate therapy for reducing white ...
Sadarangani Sapna P - - 2013
Brain abscesses in neonates are typically caused by Gram negative organisms. There are no previously described cases caused by Clostridium septicum. We present a case of a premature male infant who developed recurrent episodes of suspected necrotizing enterocolitis followed by brain abscesses, cerebritis and ventriculitis caused by Clostridium septicum.
de Vries Linda S - - 2013
Since the introduction of neonatal intensive care in the 1970s, there has been a pronounced decrease in overall mortality of premature infants as well as a decrease in the incidence of severe white matter injury, best known as cystic periventricular leukomalacia (c-PVL).(1) While cranial ultrasonography readily visualizes large lesions in ...
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