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Kaufman David A DA Department of Pediatrics University of Virginia School of Medicine, Charlottesville, VA, USA. Electronic address: - - 2014
To better understand the impact of hypoxia and hyperoxia on neonatal morbidity and mortality, we examined the number of hypoxia and hyperoxia events as well as percentage of time spent outside oxygen saturation targets in relationship to threshold retinopathy of prematurity (tROP) and mortality in preterm infants. Saturation data in ...
Corvaglia Luigi L Neonatology and Neonatal Intensive Care Unit, Department of Medical and Surgical Sciences, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, - - 2014
We evaluated the effects of bolus vs continuous tube feeding on cardiorespiratory events, detected by polysomnographic monitoring, in healthy preterm infants. Continuous tube feeding resulted in a significant increase of apneas and apneas-related hypoxic episodes compared with bolus feeding.
Kelly Patrick P Te Puaruruhau (Child Protection Team), Department of Pediatrics, Faculty of Medical and Health Sciences, University of Auckland, New Zealand; - - 2014
It has been suggested that there is a causal relationship between hypoxia and subdural hemorrhage (SDH) in infancy. The purpose of this study was to review the incidence of SDH in infants with congenital heart disease and explore the relationship between SDH and hypoxia. Review of data collected for a ...
Florescu Laura L Discipline of Infant Care, University of Medicine and Pharmacy "Grigore T. Popa"- - - 2013
The aim of the present study was to investigate the frequency of methicillin-resistant S. aureus (MRSA) colonization in infants with protein-energy malnutrition (PEM) and to characterize the antibiotic susceptibility patterns in isolated strains. The study included 123 infants with PEM, admitted to the Paediatric Rehabilitation Department of,,St. Mary" Emergency Clinical ...
Kilsby Amanda - - 2013
Extracorporeal membrane oxygenation (ECMO) was first used in adults with severe respiratory failure in the 1970s. Its use has been steadily increasing since the 1990s after a trial demonstrated improved survival. There are currently seven centres in the UK offering ECMO to adults. Neurological complications are often picked up within ...
Hilton Tara C - - 2012
ABSTRACT: The American Academy of Pediatrics (AAP) has a long-standing recommendation against breastfeeding if the maternal methadone dose is above 20 mg/day. In 2001, the AAP lifted the dose restriction of maternal methadone allowing methadone-maintained mothers to breastfeed. The allowance of breastfeeding among mothers taking methadone has been met with ...
Walhovd Kristine B - - 2012
The early cerebral connective tract development of infants born to methadone-maintained mothers and comparison infants was examined using diffusion tensor imaging. Drawing on animal models, we hypothesized higher mean diffusivity in methadone-exposed infants, corresponding to the delayed or altered maturation of neural connective tracts. Thirteen methadone-exposed infants and seven comparison ...
Heil Sarah H - - 2012
Pupil diameter is a frequently assessed objective index of the pharmacodynamic effects of opioids in adults, but to our knowledge has never been examined in infants. Such a measure could improve assessment and treatment of neonates exposed to opioids in utero. The present study examined changes in pupil diameter after ...
Himes Sarah K SK Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, - - 2012
Methadone is the recommended pharmacotherapy for opioid-dependent pregnant women. The primary aims of this study were to determine whether a dose-concentration relationship exists between cumulative maternal methadone dose, methadone and metabolite concentrations in maternal hair during pregnancy and whether maternal hair methadone and metabolite concentrations predict neonatal outcomes. Hair specimens ...
Cleary Brian J BJ Pharmacy Department, Coombe Women and Infants University Hospital, Cork Street, Dublin 8, Ireland. - - 2012
  Methadone use in pregnancy has been associated with adverse perinatal outcomes and neonatal abstinence syndrome (NAS). This study aimed to examine perinatal outcomes and NAS in relation to (i) concomitant drug use and (ii) methadone dose.   Prospective cohort study.   Two tertiary care maternity hospitals.   A total ...
Hodgson Zoë G - - 2012
Objective: The purpose of this study was to explore the effect of our rooming-in protocol on the need to treat withdrawal in the opiate-exposed newborn. Methods: We reviewed the medical records of mother-infant dyads born between October 1, 2003, and December 31, 2006, who received care in our rooming-in program. ...
Bartu Anne E - - 2012
BACKGROUND: Buprenorphine, a partial opioid agonist used in treating opioid dependence, is not approved in Australia for use in pregnancy. Nevertheless, many pregnant women choose to remain on the drug. AIM: To investigate cord/maternal transfer ratios for buprenorphine and norbuprenorphine in women at delivery. METHODS: Maternal and cord serum samples ...
Morentin Benito - - 2012
INTRODUCTION AND OBJECTIVES: Infectious diseases are one of the major causes of sudden death, but data of sudden unexpected death from infectious diseases (SUDID) are sparse in children and young people. The aim of this study is to analyse their epidemiological, clinical, pathological and microbiological characteristics. METHODS: Population observational study ...
Takenouchi Toshiki - - 2012
Perinatal brain injury in term infants remains a significant clinical problem. Recently a change appears to have occurred in the pattern of such injuries. We sought to characterize the incidence, etiology, clinical manifestations, and outcomes of these injuries. A retrospective chart review identified clinical characteristics of neuroimaging, electroencephalography, and placental ...
Onesti Maria Giuseppina - - 2012
In neonatal intensive care units, extravasation is one of the most common injuries occurring in infants as a complication of infusion therapy. These very preterm infants have immature skin which is easily damaged. They often require a longer duration of intravenous therapy, and obtaining intravenous access can be difficult. An ...
Kelly Lauren E - - 2012
BackgroundThe prevalence of opioid abuse is increasing in North America. Opioid abuse during pregnancy can cause medical, obstetric and psychosocial complications. Neonates exposed to opioids in utero often develop the neonatal abstinence syndrome. Methadone maintenance therapy is the treatment of choice for maternal opioid dependency. There have been unsupported concerns ...
Lee J-H JH Department of Anesthesiology and Pain Medicine, Seoul National University Hospital, Seoul, Republic of - - 2012
Remote ischaemic preconditioning (RIPC) can reduce ischaemic-reperfusion injury in distant organs. The myocardial and pulmonary protective effect of RIPC in infants with pulmonary hypertension remains unclear. We conducted a randomized controlled trial to evaluate the effect of RIPC in infants receiving ventricular septal defect (VSD) repair. We studied 55 infants ...
Ozdemir Ramazan - - 2011
Central venous catheters ara commonly used in neonatal intensive care units as routes of parenteral nutrition. Pleural effusions caused by extravasation of parenteral alimentation fluid are a rare complication of central venous catheters in the newborn. Diaphragmatic paralysis due to phrenic nevre injury is a rare respiratory condition which may ...
Bellieni C V - - 2011
The aim of this paper was to assess brain injury occurrence among in vitro fertilization (IVF) babies. We examined all babies born in our hospital in the triennium 2004-2006, comparing the presence of brain injuries between IVF babies and the rest of the population. In IVF group (180 babies), brain ...
Wisser Matthias - - 2011
In cases of suspected neonaticide, the results of a forensic autopsy might be important for conviction or acquittal. But autopsy findings in dead newborns are often unspecific and can rarely provide corroborative evidence of inflicted injury, as they are known to occur during normal birth as well. In our study, ...
Naini Bita V - - 2011
Total parenteral nutrition (TPN) therapy is a well-recognized cause of liver injury. The histologic changes attributed to TPN in the literature vary widely. In this study, we describe the histopathologic changes associated with TPN therapy and relate these changes to various clinical parameters. We conducted a retrospective study of 89 ...
Pannell Dylan - - 2011
: As part of its contribution to the Global War on Terror and North Atlantic Treaty Organization's International Security Assistance Force, the Canadian Forces deployed to Kandahar, Afghanistan, in 2006. We have studied the causes of deaths sustained by the Canadian Forces during the first 28 months of this mission. ...
Altman Robin L - - 2011
A consortium of the 19 community hospitals and 1 tertiary care children's hospital that provide maternity care in the New York State Hudson Valley region implemented a program to teach parents about the dangers of shaking infants and how to cope safely with an infant's crying. This study evaluated the ...
Roze Elise E Centre for the Developing Brain, Imperial College, Hammersmith Campus, London, - - 2012
Our aims were to (1) assess the corticospinal tracts (CSTs) in infants with focal injury and healthy term controls using probabilistic tractography and (2) to correlate the conventional magnetic resonance imaging (MRI) and tractography findings in infants with focal injury with their later motor function. We studied 20 infants with ...
Andersen C C - - 2011
The overwhelming majority of very preterm newborns receive at least one transfusion during their in hospital stay. However, despite two recent randomised trials, the appropriate haemoglobin transfusion threshold in these high risk infants remains unclear. Typically, clinicians consider gestation, chronologic age and illness severity in order to determine the need ...
Laitakari Elina - - 2011
To investigate burn injuries requiring hospitalization sustained during the first year of life, clinical data collected during hospital treatment of infants younger than 1 year were reviewed. The principal aim was to chart the etiology and mechanism of burn injuries in this group to focus on the necessary preventive measures. ...
Squier Waney - - 2011
The "Shaken Baby" syndrome (SBS) is the subject of intense controversy; the diagnosis has in the past depended on the triad of subdural haemorrhage (SDH), retinal haemorrhage and encephalopathy. While there is no doubt that infants do suffer abusive injury at the hands of their carers and that impact can ...
Tekes Aylin - - 2011
Birth-related injury is defined as any traumatic or ischemic event sustained during the process of delivery. Perinatally acquired disease processes secondary to birth-related injury can be traumatic or ischemic in nature. In this article, the authors focus on traumatic/mechanical injuries. Other diseases of the perinatal time period, including germinal matrix ...
Mosca Fabio - - 2011
Bronchopulmonary dysplasia (BPD) is still one of the main long term complication of preterm birth, and it is the most common chronic respiratory disease in infants. Due to advances in perinatal care and neonatal respiratory therapy the clinical characteristics and the natural history of infants affected by BPD have widely ...
Kibayashi Kazuhiko - - 2011
The bed is thought to be a safe place, but posses a number of risks that can cause deaths. To identify the causes of accidental death in bed and propose strategies for the prevention of further accidents, we surveyed and analyzed the literature on accidental deaths in bed from Japan ...
Tinker Sarah C - - 2011
Tinker SC, Reefhuis J, Dellinger AM, Jamieson DJ, the National Birth Defects Prevention Study. Maternal injuries during the periconceptional period and the risk of birth defects, National Birth Defects Prevention Study, 1997-2005. Paediatric and Perinatal Epidemiology 2011; 25: 487-496. Maternal injuries during pregnancy are common (∼7% prevalence). However, few studies ...
Filler Guido M - - 2011
Definitions of pediatric acute kidney injury (AKI) use changes of serum creatinine. There is a paucity of well-designed studies in infants because of creatinine age-dependency. The emerging role of cystatin C as a superior marker of renal dysfunction led to a carefully conducted study on AKI in infants by Zappitelli ...
Bode-Jänisch S - - 2011
Birth injury of the skull and central nervous system can be a complication of a difficult delivery, especially following forceps or vacuum-assisted delivery. Birth trauma of the head can also mimic the appearance of a non-accidental head injury and is therefore an important differential diagnosis. We report on two young ...
Pham Christina B - - 2011
While most often transient, brachial plexus birth injury can cause permanent neurologic injury. The major risk factors for brachial plexus birth injury are fetal macrosomia and shoulder dystocia. The degree of injury to the brachial plexus should be determined in the neonatal nursery, as those infants with the most severe ...
Merhar Stephanie - - 2012
Posthemorrhagic hydrocephalus (PHH) is a rare but serious outcome among premature babies in the NICU, with consequences including mortality and severe neurodevelopmental disabilities. The causes of PHH are still not entirely understood, and its prevention and treatment are controversial. Various cerebrospinal fluid biomarkers have been studied in infants with PHH ...
Volpe Joseph J - - 2011
Brain injury in the premature infant, a problem of enormous importance, is associated with a high risk of neurodevelopmental disability. The major type of injury involves cerebral white matter and the principal cellular target is the developing oligodendrocyte. The specific phase of the oligodendroglial lineage affected has been defined from ...
Askenazi David J DJ Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35233, USA. - - 2011
To test the hypothesis that noninvasive urinary biomarkers may improve early identification, differentiate causes, and predict outcomes of acute kidney injury (AKI) in very low birth weight subjects. We performed 2 nested case-control studies to compare the ability of 6 urine biomarkers to predict AKI (rise in serum creatinine of ...
Martinez-Biarge M - - 2011
Central gray matter damage, the hallmark of term acute perinatal hypoxia-ischemia, frequently leads to severe cerebral palsy and sometimes death. The precision with which these outcomes can be determined from neonatal imaging has not been fully explored. We evaluated the accuracy of early brain MRI for predicting death, the presence ...
Procianoy Renato S - - 2011
OBJECTIVE:: To examine the association among interleukin-6, interleukin-8, tumor necrosis factor-α, interleukin-10, and interleukin-1β and white matter injury in very-low-birth-weight infants with clinical sepsis and to help predict infants at risk for development of white matter injury. METHODS:: Very-low-birth-weight infants with clinical early-onset sepsis were included. The exclusion criteria were ...
Squier W - - 2011
This preliminary communication describes seven babies with β-amyloid precursor protein (βAPP) positive axonal swellings in nerve roots at multiple levels of the spinal cord. All seven babies died of natural causes. Two died in utero providing evidence for nerve root injury in the absence of trauma, two died within one ...
Ghosh Partha S - - 2011
Benign external hydrocephalus (BEH) is considered a self-limiting condition in infants. Subdural hematoma (SDH) in infants without a history of trauma indicates nonaccidental injury (NAI). The authors studied whether SDH can complicate BEH without apparent trauma. Out of 45 children younger than 3 years with nontraumatic SDH, 9 (7 boys) ...
Paris Amy E - - 2011
OBJECTIVE: The objective of the study was to determine whether a decrease in the use of episiotomy was associated with a change in the frequency of brachial plexus injury. STUDY DESIGN: All births at Brigham and Women's Hospital from Sept. 1, 1998, through Aug. 31, 2009, were reviewed. The total ...
Sukhov Andrea - - 2011
Objective. To examine pregnancy outcomes in preterm delivered children with cerebral palsy (CP). Methods. A retrospective population-based cohort study of children born in California (January 1, 1991 and December 31, 2001) with CP were identified (State databases) and compared to children without CP. We examined demographic data and pregnancy outcomes by gestational ...
Gasparella M - - 2011
The nasogastric tube is the chosen nutritional technique in premature infants. However, it is not without complications. The aim of this study is to compare our experience in iatrogenic complications caused by nasogastric tube (especially in very low birth weight infants) to a review of the most recent literature. From ...
Inder Terrie E - - 2011
ABSTRACT: With the wider use of magnetic resonance imaging, the recognition of different patterns of injury has become established. These patterns vary in relation to the level of immaturity of the infant. This review will outline the major patterns of abnormality that are found in the term born and preterm ...
Wilkinson Dominic James DJ Oxford Uehiro Centre for Practical Ethics, Littlegate House, St Ebbes St., Oxford, United Kingdom. - - 2011
When is it permissible to allow a newborn infant to die on the basis of their future quality of life? The prevailing official view is that treatment may be withdrawn only if the burdens in an infant's future life outweigh the benefits. In this paper I outline and defend an ...
Mehta Shobha H - - 2011
Neonatal brachial plexus injury (BPI) is a birth outcome characterized by injury to the brachial plexus identified after delivery. Though uncommon, its potential occurrence following delivery is concerning for both the delivering clinician as well as the pediatric team. Considerable research looking at delivery factors, including forces applied at the ...
Omoniyi-Esan Olutoyin - - 2011
The aim of this study was to review autopsies to determine the pattern of deaths in females at Wesley Guild Hospital, Ilesa, Nigeria. A 9-year retrospective study was done of all autopsies done on females in the Department of Morbid Anatomy and Forensic Medicine, Obafemi Awolowo University Teaching Hospitals Complex, ...
Ray Robbie - - 2011
Blood sampling through heel lancing is the most common invasive painful procedure performed on newborn infants. We report the case of a five day old infant who sustained burns to the left foot and leg after the mother's hairdryer was used by the midwife to warm the baby's heel prior ...
Hill C A CA University of Connecticut, Storrs, Conn., - - 2011
Hypoxia-ischemia (HI; concurrent oxygen/blood deficiency) and associated encephalopathy represent a common cause of neurological injury in premature/low-birth-weight infants and term infants with birth complications. Resulting behavioral impairments include cognitive and/or sensory processing deficits, as well as language disabilities, and clinical evidence shows that male infants with HI exhibit more severe ...
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