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Srikartika Vm V Centre for Population Health Research, Curtin University, Perth, - - 2014
To examine fetal outcomes of mothers with an alcohol-related diagnosis. Population-based cohort. Western Australia (WA). Births on the WA Midwives Notification System (1983-2007). Infants of mothers with an alcohol-related diagnosis [International Classification of Disease (ICD), 9th/10th revisions] recorded on WA health data sets (non-Aboriginal n = 13 807; Aboriginal n = 9766) were identified through ...
Janota Jan J Department of Neonatology, Thomayer Hospital Prague, Czech Republic; Institute of Pathological Physiology, First Medical Faculty, Charles University in Prague, Czech - - 2014
To assess the impact of a hand hygiene protocol, using hand washing, alcohol hand rub and gloves when caring for preterm infants born after 31 weeks of gestation, on the incidence of neonatal late onset sepsis (LOS). All babies delivered between 32+0 and 36+6 weeks gestation and admitted to the ...
Castle I-Jen P IJ CSR, Incorporated, Arlington, - - 2014
ABSTRACT. Objective: We used motor vehicle traffic (MVT) crash fatalities as an example to examine the extent of underreporting of alcohol involvement on death certificates and state variations. Method: We compared MVT-related death certificates identified from national mortality data (Multiple Cause of Death [MCoD] data) with deaths in national traffic ...
Bakhireva Ludmila N LN Department of Pharmacy Practice and Administrative Sciences, UNM, Albuquerque, New Mexico; Department of Family and Community Medicine, UNM, Albuquerque, New - - 2014
Accurate identification of prenatal alcohol exposure (PAE) in the newborn period offers an opportunity for early identification of children at risk of future neurocognitive problems and the implementation of interventional approaches earlier in life. PAE newborn screening by measuring phosphatidylethanol in dried blood spot (PEth-DBS) cards is feasible, logistically easier, ...
Fong Hiu-Fai HF From the *Department of Pediatrics, The Children's Hospital of Philadelphia; Robert Wood Johnson Foundation Clinical Scholars Program and Leonard Davis Institute of Health Economics, The Perelman School of Medicine at the University of Pennsylvania; and †The Institute for Continuing Healthcare Education and the University of Pennsylvania School of Veterinary Medicine, Philadelphia, - - 2014
Ethanol exposure can affect all pediatric age groups but occurs most commonly in ambulatory children and adolescents. Infants are less likely to ingest ethanol because they have limited ability to explore their environments. However, ethanol exposures in infants can occur. We report the case of a 29-day-old (3.5 kg) baby ...
Schuetze Pamela P Department of Psychology, State University of New York College at Buffalo, 1300 Elmwood Avenue, Buffalo, NY 14222-1095; Research Institute on Addictions, SUNY University at Buffalo, 1021 Main Street, Buffalo, NY 14203; Department of Pediatrics, SUNY University at Buffalo School of Medicine, Buffalo, NY. Electronic address: - - 2014
This study examined the association between prenatal exposure to cocaine and behavioral and fme. Participants were 216 mother-infant dyads (116 cocaine exposed-CE, 100 nonexposed-NCE) recruited at birth. Measures of heart rate (HR) and respiratory sinus arrhythmia (RSA) were obtained during baseline and during a task designed to elicit empathy (exposure ...
Barreca Alan A Economics, Tulane University, New Orleans, - - 2013
Minimum legal drinking age (MLDA) laws are known to reduce alcohol consumption among young adults. One additional benefit of higher MLDAs may be that they improve health outcomes among infants born to young mothers. We estimate the impact of MLDAs on infant health in the USA by comparing birth outcomes ...
Spiegler J J Department of Pediatrics, University of Luebeck, Luebeck, - - 2013
Nicotine and alcohol consumption have been associated with premature delivery and adverse neonatal outcome. We wanted to analyze the influence of self-reported nicotine and alcohol consumption on outcome of VLBW infants.In an ongoing multicenter study 2 475 parents of former very low birth weight (VLBW) infants born between January 2009 and ...
Golub Mari S - - 2013
Minimal scientific information is available to inform public health policy on binge drinking prior to pregnancy detection. The nonhuman primate provides a valuable animal model for examining consequences to reproduction and offspring function that may result from this common pattern of alcohol abuse. Adult female rhesus monkeys were dosed with ...
Haastrup Maija Bruun - - 2013
While the harmful effects of alcohol during pregnancy are well established, the consequences of alcohol intake during lactation have been far less examined. We reviewed available data on the prevalence of alcohol intake during lactation, the influence of alcohol on breastfeeding, the pharmacokinetics of alcohol in lactating women and nursing ...
McAteer Jarod P JP Division of Pediatric General and Thoracic Surgery, Seattle Children's Hospital, Seattle, WA 98105; Department of Surgery University of Washington School of Medicine, Seattle, WA 98105. Electronic address: - - 2014
Maternal factors contributing to the etiology of congenital diaphragmatic hernia (CDH) remain unclear. We hypothesized that specific maternal medical conditions (pregestational diabetes, hypertension), and behaviors (alcohol, tobacco) would be associated with CDH. We conducted a population-based case-control study using Washington State birth certificates linked to hospital discharge records (1987-2009). We ...
Almqvist-Tangen Gerd - - 2013
Infant feeding affects growth, obesity and life-long health. This study examined the impact of dietary patterns on body mass index (BMI) at 12 and 18 months. We followed a cohort of 2,666 children recruited in 2007-2008. Feeding practices were obtained from parental questionnaires and anthropometric data collected by child health ...
Molteno Christopher D - - 2013
Our aim was to test the hypothesis that emotional withdrawal is an early indicator of affective disorder in infants heavily exposed prenatally to alcohol, which is independent of alcohol-related effects on mother-infant interaction and temperament and discriminated between children later diagnosed with fetal alcohol syndrome (FAS) and partial FAS (PFAS) ...
McGlone Laura - - 2013
To describe the prevalence of in utero alcohol and illicit drug exposure in infants born to mothers prescribed methadone in pregnancy, and to compare the accuracy of maternal interview with infant toxicology. Urine and meconium samples were collected from 56 infants born to mothers prescribed methadone during pregnancy and a ...
Conradt Elisabeth - - 2013
OBJECTIVE: To examine the autonomic nervous system and neurobehavioral response to a sustained visual attention challenge in 1-month-old infants with prenatal substance exposure. STUDY DESIGN: We measured heart rate, respiratory sinus arrhythmia, and neurobehavior during sustained visual orientation tasks included in the Neonatal Intensive Care Unit Network Neurobehavioral Scale in ...
Behnke Marylou - - 2013
Prenatal substance abuse continues to be a significant problem in this country and poses important health risks for the developing fetus. The primary care pediatrician's role in addressing prenatal substance exposure includes prevention, identification of exposure, recognition of medical issues for the exposed newborn infant, protection of the infant, and ...
O'Leary Colleen M CM Centre for Population Health Research, Curtin Health Innovation Research Institute, Curtin University, Perth, Western Australia. - - 2013
Improvements in the rate of infant mortality (death in first year of life) have not occurred in recent years. This study investigates the association between maternal alcohol-use disorder and sudden infant death syndrome (SIDS) and infant mortality not classified as SIDS using linked, population-based health and mortality data. Exposed mothers ...
Krajcovic Jozef - - 2013
This report describes an unusual case of a 2.5-month-old infant's sudden death secondary to giant cell myocarditis and endomyocardial calcification, both unusual entities in pediatric patients. The mother had a history of excessive alcohol consumption during pregnancy and the postnatal period. No infectious etiologies, hypersensivity, or autoimmune disorders were identified. ...
Ford Jonathan B JB Department of Emergency Medicine, School of Medicine, University of California, Davis, 4150 V Street, PSSB 2100, Sacramento, CA 95817, - - 2013
Primary ethanol metabolism occurs through alcohol dehydrogenase, but minor metabolic pathways such as the P450 enzymes CYP2E1 and CYP1A2 and the enzyme catalase exist. These enzymes have distinct developmental stages. Elimination kinetics of ethanol in the infant is limited. We report the elimination kinetics of ethanol in a 5-week-old African-American ...
Harari Florencia - - 2012
The transfer of lithium and boron from exposed mothers to fetuses and breast-fed infants was investigated in areas in northern Argentina and Chile with up to 700μglithium/L and 5-10mgboron/L in drinking water. Maternal and cord blood concentrations were strongly correlated and similar in size for both lithium (47 and 70μg/L, ...
Giliberti Danielle D Department of Paediatrics, Division of Neonatal-Perinatal Medicine, Emory University, Emory Children's Centre for Developmental Lung Biology, 2015 Uppergate Dr. NE, Atlanta, GA 30322, USA. - - 2013
In utero alcohol exposure dramatically increases the risk of premature delivery. However, the majority of premature and term newborns exposed to alcohol remain undetected by medical caregivers. There is a desperate need for reliable and accurate biomarkers of alcohol exposure for the term and premature newborn population. The inability to ...
Consigli C C Neonatal Intensive Care Unit, “S. Pietro Fatebenefratelli” Hospital, Rome, - - 2012
Congenital chylothorax (CC) is a rare and potentially life-threatening condition. Over 50% occurs at birth and is considered as the most common cause of neonatal thoracic fluid collection. To analyse the main clinical and respiratory features of a contemporary group of CC infants. Databases for CC diagnosed between 2004 and ...
Sanchez-Solis Manuel - - 2011
OBJECTIVE: Both healthy preterm infants and those with bronchopulmonary dysplasia (BPD) have poor lung function during childhood and adolescence, although there is no evidence whether prematurity alone explains the reduction in lung function found in BPD infants. Our study seeks to know if lung function, measured in infancy by means ...
Lewander Màˆrta - - 2011
A feasibility study on noninvasive, real-time monitoring of gases in lungs of preterm infants is reported, where a laser-spectroscopic technique using diode lasers tuned to oxygen and water vapor absorption lines was employed on realistic tissue phantoms. Our work suggests that the technique could provide a new possibility for surveillance ...
Miedema Martijn - - 2012
To assess the regional respiratory time constants of lung volume changes during stepwise lung recruitment before and after surfactant treatment in high-frequency oscillatory ventilated preterm infants. A stepwise oxygenation-guided recruitment procedure was performed before and after surfactant treatment in high-frequency oscillatory ventilated preterm infants. Electrical impedance tomography was used to ...
Ahlfeld Shawn K SK Developmental Biology and Neonatal Medicine Program, H.B. Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana. - - 2012
Bronchopulmonary dysplasia (BPD) is a chronic lung disease in infants born extremely preterm, typically before 28 weeks' gestation, characterized by a prolonged need for supplemental oxygen or positive pressure ventilation beyond 36 weeks postmenstrual age. The limited number of autopsy samples available from infants with BPD in the postsurfactant era ...
Smart David E - - 2011
Currently attributed to a lack of foetal lung development, respiratory distress syndrome is the eighth largest cause of infant mortality (USA). Corticosteroids have proved successful but are not infallible in this indication having both a 24-hour latency and little effect on surfactant production. In vivo evidence shows a triggering event ...
Palojärvi Anniina - - 2011
Aim:  In preterm infants, inflammation and intra-alveolar fibrin formation characterize respiratory distress syndrome (RDS). Tissue factor (TF) is a link between inflammation and coagulation pathways. We investigated the relationship between TF and cytokines in preterm infants to gain information of the role of TF in the inflammatory response. Methods:  We ...
Rehan Virender K VK Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California 90502, USA. - - 2011
The mechanism underlying the potentially beneficial effects of the "gentler" modes of ventilation on chronic lung disease (CLD) of the premature infant is not known. We have previously demonstrated that alveolar parathyroid hormone-related protein-peroxisome proliferator-activated receptorγ (PTHrP-PPARγ) signaling is critically important in alveolar formation, and this signaling pathway is disrupted ...
Riley Cheryl A - - 2011
Corticosteroids administered to women in preterm labor are the standard of care for reducing neonatal morbidity and mortality associated with prematurity. These agents promote lung development and reduce the incidence of neonatal intraventricular hemorrhage. Several studies have investigated the method by which fetal lung fluid is cleared after birth. This ...
Sarria E E - - 2012
The aims of this study were to determine whether infants and toddlers with chronic lung disease of infancy (CLDI) have smaller airways and lower lung density compared with full-term healthy controls. Multi-slice computed tomography (CT) chest scans were obtained at elevated lung volumes during a brief respiratory pause in sedated ...
Gizzi Camilla - - 2011
Mechanical ventilation is often required by very preterm infants with respiratory failure, even if invasive respiratory support is related to lung injury and adverse neurologic outcomes. The exposure to mechanical ventilation should be therefore limited. Optimal extubation however remains challenging, as approximately 30% of intubated preterm infants fails attempted extubation ...
Vedovelli Luca - - 2011
Disaturated-phosphatidylcholine (DSPC) and phosphatidylglycerol (PG) are respectively the first and the third most abundant phospholipid in human alveolar surfactant. Their concentration decreases in airway surfactant of adults and infants with respiratory distress syndrome and cystic fibrosis. In this study, we used mass spectrometry (IRMS) to investigate the turnover of DSPC ...
Williams Olivia - - 2011
Mid-trimester, preterm prelabour rupture of the membranes (PPROM) with prolonged oligohydramnios remains a challenge for both obstetricians and neonatologists. Although survival rates have improved, morbidity remains common particularly due to pulmonary insufficiency and pulmonary hypertension. The aetiology of abnormal lung development is unknown but may depend critically on pulmonary vascular ...
Hough Judith L - - 2011
RATIONALE:: Although continuous positive airway pressure is used extensively in neonatal intensive care units, and despite the belief that positioning is considered vital to the maintenance of good lung ventilation, no data exist on regional ventilation distribution in infants on continuous positive airway pressure ventilatory support. OBJECTIVES:: To investigate the ...
May Caroline - - 2011
ObjectiveTo determine if infants developing bronchopulmonary dysplasia (BPD), particularly mild BPD, initially had minimal lung function abnormalities, which then worsened throughout the neonatal period.DesignProspective observational study.SettingTertiary neonatal intensive care unit.Patients74 infants with a median gestational age of 30 weeks (24-32) and birth weight of 1200 g (474-2000) were studied; 35 ...
Viscardi Rose Marie RM Department of Pediatrics, University of Maryland School of Medicine, 29 S. Greene St., Rm GS110, Baltimore, MD 21201, USA. - - 2012
Bronchopulmonary dysplasia (BPD) remains the major morbidity of extreme preterm birth. The incidence of BPD has remained stable despite recent efforts to reduce postnatal exposures to volutrauma and hyperoxia. This review will focus on recent clinical and experimental insights that provide support for the concept that the 'new BPD' is ...
Vento G - - 2011
Background: In clinical practice, one of the major problems in optimizing recruitment or lung volume during HFOV in preterm infants is the inability to accurately measure direct changes in lung volume at bedside. Objective: To evaluate changes in lung volume during the recruitment phase of elective HFOV in preterm infants ...
Dekoninck Philip - - 2011
In isolated congenital diaphragmatic hernia, lung size and/or the position of the liver are predictive of neonatal outcome. Percutaneous Fetal Endoscopic Tracheal Occlusion (FETO) by a balloon can be undertaken to prompt lung growth in the worst cases. The feasibility and safety of FETO is no longer at stake, and ...
Wiswell Thomas E - - 2011
Resuscitation of newborn infants occurs in approximately 10% of the more than 100 million infants born annually worldwide. The techniques used during resuscitation, such as positive-pressure ventilation and supplemental oxygen, may revive many infants, but have the potential to harm their lungs. In recent years increasing attention has been applied ...
Lee Inn-Chi - - 2011
Myotubular myopathy is a rare congenital disease characterized by hypotonia and respiratory compromise at birth in affected males. It causes high neonatal mortality. Most surviving newborns need prolonged ventilation and have significantly delayed motor development. Although all patients with congenital myotubular myopathy have respiratory problems such as atelectasis and recurrent ...
Kugelman Amir - - 2011
The current bronchopulmonary dysplasia (BPD) is seen in infants born extremely premature, with less severe respiratory distress syndrome (RDS) and who received prenatal steroids-"new BPD". The pathophysiology of BPD is based on an impairment of lung maturation with prenatal and postnatal multi-hit insults and genetic susceptibility. This multifactorial pathophysiology of ...
Witlox Ruben S - - 2011
Congenital lung lesions, mostly congenital cystic adenomatoid malformations (CCAMs) and bronchopulmonary sequestrations (BPSs), are uncommon disorders. Prenatal intervention in severely affected (hydropic) fetuses has drastically improved perinatal survival. Not much is known, however, on the short-term and long-term respiratory and neurodevelopmental outcome. Several small case series have been reported and ...
Jupelli Madhulika M Department of Biology, South Texas Center for Emerging Infectious Disease, University of Texas at San Antonio, San Antonio, TX 78249, - - 2011
Respiratory dysfunction in adults has been correlated with neonatal Chlamydia trachomatis pneumonia in several studies, but a causal association has not been clearly demonstrated. In this study, we examined radial alveolar counts (RACs) by microscopy, and airway and parenchymal lung function using a small animal ventilator in juvenile (5 weeks ...
Hung Shih-Pin - - 2011
Misalignment of lung vessels (MLV) with or without alveolar capillary dysplasia (ACD) is a rare cause of idiopathic persistent pulmonary hypertension of the neonate. This report describes a full-term infant with severe and intractable pulmonary hypertension. The patient's condition progressively deteriorated despite high-frequency oscillatory ventilation, infusion of magnesium sulfate, dopamine, ...
Bouziri Asma A Childrens's Hospital, Tunis, - - 2011
High-frequency oscillatory ventilation (HFOV) has been advocated for use to improve lung inflation while potentially decreasing lung injury. There were few data on the early use of HFOV in hypoxemic term neonates. To evaluate the effectiveness of HFOV, used as the initial mode of ventilation, in neonates with severe meconium ...
Turner Mark A - - 2011
Chronic lung disease of prematurity (CLD) remains a major cause of morbidity and mortality in preterm infants. Ureaplasma has received intermittent attention over the last two decades as a possible contributory factor. In addition, pulmonary inflammation is associated with the development of CLD. The macrolide azithromycin provides an attractive option ...
Newman Julie Bapp - - 2011
Objective: The neuropsychological outcome of chronic lung disease (CLD) in the very preterm (VP) infant may be determined by a process involving chronic hypoxia, with superimposed acute hypoxic episodes, in the developing brain. We wished to study the differences in quality of outcome between VP preschoolers with and without history ...
Gupta Samir - - 2011
Non-invasive respiratory support techniques such as continuous positive airway pressure (CPAP) have been increasingly used for management of surfactant-deficient lung disease in preterm infants. The successful use of this approach depends upon the condition of the baby at birth and requires the establishment of spontaneous breathing at birth. The reported ...
Manzardo Ann M - - 2011
A large Danish birth cohort was used to test the independent and joint effects of perinatal measures associated with premature birth as predictors of the development of alcoholism in male and female subjects. Subjects were born at the Copenhagen University Hospital between 1959 and 1961 (N = 9,125). A comprehensive ...
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