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Robinson Karl E KE Queensland Alliance for Agriculture and Food Innovation, Centre for Animal Science, The University of Queensland, Level 3, Ritchie Building (64C), Research Road, St Lucia, QLD, 4072, - - 2015
A critical factor in the study of herpesviruses, their genes and gene functions is the capacity to derive mutants that harbor deletions, truncations, or insertions within the genetic elements of interest. Once constructed the impact of the introduced mutation on the phenotypic properties of the rescued virus can be determined ...
Betsiashvili Mariam M Boyce Thompson Institute for Plant Research, Ithaca, New York, 14853, - - 2014
Plants show considerable within-species variation in their resistance to insect herbivores. In the case of Zea mays (cultivated maize), Rhopalosiphum maidis (corn leaf aphids) produce approximately twenty times more progeny on inbred line B73 than on inbred line Mo17. Genetic mapping of this difference in maize aphid resistance identified quantitative ...
Nishio Jun J Department of Orthopaedic Surgery, Faculty of Medicine, Fukuoka University, Fukuoka, Japan - - 2014
Diffuse-type tenosynovial giant cell tumor (TSGCT) is a locally aggressive neoplasm that primarily affects the synovium and tendon sheath in young adults. Rearrangement of chromosome band 1p13 is now considered a characteristic genetic feature of TSGCT, with the most frequent chromosomal alteration t(1;2)(p13;q37). Here, we describe a unique cytogenetic finding ...
Kodama Tatsushi T *Research Division, Chugai Pharmaceutical Co., Ltd., Kamakura, Japan; †Division of Pathology, The Cancer Institute; ‡Division of Clinical Chemotherapy, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research; and §Department of Pathology, The Cancer Institute Hospital, Tokyo, - - 2014
EML4-ALK is a driver oncogene in non-small-cell lung cancer (NSCLC) and has been developed into a promising molecular target for antitumor agents. Although EML4-ALK is reported to be formed by inversion of chromosome 2, other mechanisms of this gene fusion remain unknown. This study aimed to examine the mechanism of ...
Srivastava Amit Kumar AK National Centre of Applied Human Genetics, School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, - - 2014
Inundation of evolutionary markers expedited in Human Genome Project and 1000 Genome Consortium has necessitated pruning of redundant and dependent variables. Various computational tools based on machine-learning and data-mining methods like feature selection/extraction have been proposed to escape the curse of dimensionality in large datasets. Incidentally, evolutionary studies, primarily based ...
Montpetit Alison J AJ Alison J. Montpetit, PhD, RN, is Assistant Professor, School of Nursing, Virginia Commonwealth University, Richmond. Areej A. Alhareeri, BS, is Graduate Student, School of Medicine, Virginia Commonwealth University, Richmond. Marty Montpetit, PhD, is Assistant Professor; and Angela R. Starkweather, PhD, ACNP-BC, CNRNA, is Associate Professor, School of Nursing, Virginia Commonwealth University, Richmond. Lynne W. Elmore, PhD, is Associate Professor, School of Medicine, Virginia Commonwealth University, Richmond. Kristin Filler, RN, BS, is Doctoral Student Fellow; Lathika Mohanraj, PhD, is Postdoctoral Fellow; Candace W. Burton, PhD, RN, FNE, is Assistant Professor; and Victoria S. Menzies, PhD, RN, PMHCNS-BC, is Assistant Professor, School of Nursing, Virginia Commonwealth University, Richmond. Debra E. Lyon, PhD, RN, FNP-BC, FNAP, FAAN, is Executive Associate Dean, and Thomas M. and Irene B. Kirbo Endowed Chair, College of Nursing, University of Florida, Gainesville. Colleen K. Jackson-Cook, PhD, is Professor, School of Medicine, Virginia Commonwealth University, - - 2014
The exciting discovery that telomere shortening is associated with many health conditions and that telomere lengths can be altered in response to social and environmental exposures has underscored the need for methods to accurately and consistently quantify telomere length. The purpose of this article is to provide a comprehensive summary ...
de Chadarevian Soraya S University of California Los Angeles, Department of History and Institute for Society and Genetics, 6265 Bunche Hall, Los Angeles, CA 90095-1473, USA. Electronic address: - - 2014
It is commonly held that after 1945 human genetics turned medical and focussed on the individual rather than on the study of human populations that had become discredited. However, a closer look at the research practices at the time quickly reveals that human population studies, using old and new tools, ...
Diekstra Frank P FP Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The - - 2014
Objective: Substantial clinical, pathological and genetic overlap exists between amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). TDP-43 inclusions have been found in both ALS and FTD cases (FTD-TDP). Recently, a repeat expansion in C9orf72 was identified as the causal variant in a proportion of ALS and FTD cases. We ...
Karafet Tatiana M TM ARL Division of Biotechnology, University of Arizona, Tucson, AZ, - - 2014
The highly structured distribution of Y-chromosome haplogroups suggests that current patterns of variation may be informative of past population processes. However, limited phylogenetic resolution, particularly of subclades within haplogroup K, has obscured the relationships of lineages that are common across Eurasia. Here we genotype 13 new highly informative single-nucleotide polymorphisms ...
Chaste Pauline P Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; FondaMental Foundation, Créteil, - - 2014
The proximal region of chromosome 15 is one of the genomic hotspots for copy number variants (CNVs). Among the rearrangements observed in this region, CNVs from the interval between the common breakpoints 1 and 2 (BP1 and BP2) have been reported cosegregating with autism spectrum disorder (ASD). Although evidence supporting ...
Phillips-Cremins Jennifer E JE Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19103, USA. Electronic address: - - 2014
Genomes are folded into sophisticated configurations that both shape, and are shaped by, a diverse range of nuclear functions. High-throughput variations of Chromosome-Conformation-Capture-based technologies now enable analysis of architecture at unprecedented resolution and scale. Here I discuss the complex structure-function relationship of the mammalian genome using the model system of ...
Gautier Mathieu M INRA, UMR CBGP (INRA { IRD-Cirad-Montpellier SupAgro), Campus international de Baillarguet, CS 30016, F-34988, Montferrier-sur-Lez, France; Institut de Biologie Computationnelle, 95 rue de la Galera, 34095, Montpellier, - - 2014
The recent democratisation of next-generation sequencing based approaches towards non-model species has made it cost-effective to produce large genotyping data sets for a wider range of species. However, when no detailed genome assembly is available, poor knowledge about the organisation of the markers within the genome might hamper the optimal ...
Larsen Camilla T CT Department of Mathematical Sciences, NTNU NO-7491, Trondheim, - - 2014
Genetic evaluation using animal models or pedigree-based models generally assume only autosomal inheritance. Bayesian animal models provide a flexible framework for genetic evaluation, and we show how the model readily can accommodate situations where the trait of interest is influenced by both autosomal and sex-linked inheritance. This allows for simultaneous ...
Herrera Brianne B Department of Anthropology, The Ohio State University, Columbus, - - 2014
Different data types have previously been shown to have the same microevolutionary patterns in worldwide data sets. However, peopling of the New World studies have shown a difference in migration paths and timings using multiple types of data, spurring research to understand why this is the case. This study was ...
Schumer Molly M Department of Ecology and Evolutionary Biology - - 2014
Hybridization has long been considered a process that prevents divergence between species. In contrast to this historical view, an increasing number of empirical studies claim to show evidence for hybrid speciation without a ploidy change. However, the importance of hybridization as a route to speciation is poorly understood, and many ...
Everett Meredith V MV School of Aquatic and Fishery Sciences, University of Washington Seattle, WA, - - 2014
Understanding how organisms interact with their environments is increasingly important for conservation efforts in many species, especially in light of highly anticipated climate changes. One method for understanding this relationship is to use genetic maps and QTL mapping to detect genomic regions linked to phenotypic traits of importance for adaptation. ...
Bink M C A M MC Biometris, Wageningen University and Research Centre, Droevendaalsesteeg 1, P.O. Box 16, 6700 AA, Wageningen, The Netherlands, - - 2014
Proof of concept of Bayesian integrated QTL analyses across pedigree-related families from breeding programs of an outbreeding species. Results include QTL confidence intervals, individuals' genotype probabilities and genomic breeding values. Bayesian QTL linkage mapping approaches offer the flexibility to study multiple full sib families with known pedigrees simultaneously. Such a ...
Raj Revathi R Pediatric Hematology, Oncology and Marrow Transplantation Unit, Apollo Speciality Hospitals, Chennai, - - 2014
Advances in current treatment regimens in childhood acute lymphoblastic leukemia (ALL) have resulted in cure rates of 75-80 %. Some molecular genetic abnormalities confer a poor prognosis. Of these, the chromosomal translocation t (9;22)-Philadelphia chromosome is associated with the worst outcome in childhood ALL. Optimal therapy for this variant of ALL ...
Yang Jie - - 2014
In a natural population, the alleles of multiple tightly linked loci on the same chromosome co-segregate and are passed non-randomly from generation to generation. Capitalizing on this phenomenon, a group of mapping methods, commonly referred to as the linkage disequilibrium-based mapping (LD mapping), have been developed recently for detecting genetic ...
Reichert Sophie S University of Strasbourg, Institut Pluridisciplinaire Hubert Curien, Strasbourg, France; Département d'Ecologie, Physiologie et Ethologie (DEPE), CNRS UMR7178, 23 rue Becquerel, 67087 Strasbourg Cedex 2, France. Electronic address: - - 2014
Telomeres- the protective ends of linear chromosomes - reveal themselves as a good proxy in terms of longevity, but more recently also as a marker of healthy ageing in laboratory rodents. Telomere erosion is prevented by the activation of telomerase, an enzyme suspected to be also vital for tissue regeneration ...
Quillet E E INRA, UMR 1313 Génétique Animale et Biologie Intégrative, F-78350, Jouy-en-Josas, - - 2014
Better understanding of the mechanisms underlying interindividual variation in stress responses and their links with production traits is a key issue for sustainable animal breeding. In this study, we searched for quantitative trait loci (QTL) controlling the magnitude of the plasma cortisol stress response and compared them to body size ...
Signer-Hasler Heidi H School of Agricultural, Forest and Food Sciences, Bern University of Applied Sciences, Zollikofen, - - 2014
Hereditary variations in head morphology and head malformations are known in many species. The most common variation encountered in horses is maxillary prognathism. Prognathism and brachygnathism are syndromes of the upper and lower jaw, respectively. The resulting malocclusion can negatively affect teeth wear, and is considered a non-desirable trait in ...
Higgins James D JD School of Biosciences, The University of Birmingham Birmingham, - - 2014
Arabidopsis arenosa is a close relative of the model plant A. thaliana, and exists in nature as stable diploid and autotetraploid populations. Natural tetraploids have adapted to whole genome duplication and do not commonly show meiotic errors such as multivalent and univalent formation, which can lead to chromosome non-disjunction and ...
Portis Ezio E DISAFA - Plant Genetics and Breeding, University of Torino, Grugliasco, Torino, - - 2014
In spite of its widespread cultivation and nutritional and economic importance, the eggplant (Solanum melongena L.) genome has not been extensively explored. A lack of knowledge of the patterns of inheritance of key agronomic traits has hindered the exploitation of marker technologies to accelerate its genetic improvement. An already established ...
Drillon Guénola G Sorbonne Universités, UPMC Univ Paris 06, UMR 7238, Biologie Computationnelle et Quantitative, Paris, France; CNRS, UMR7238, Biologie Computationnelle et Quantitative, Paris, - - 2014
Reconstructing synteny blocks is an essential step in comparative genomics studies. Different methods were already developed to answer various needs such as genome (re-)annotation, identification of duplicated regions and whole genome duplication events or estimation of rearrangement rates. We present SynChro, a tool that reconstructs synteny blocks between pairwise comparisons ...
Williams Kirstin A KA Entomology Department, Durban Natural Science Museum, Durban, South - - 2014
Hybrids of Lucilia sericata and Lucilia cuprina have been shown to exist in previous studies using molecular methods, but no study has shown explicitly that these hybrids can be identified morphologically. Published morphological characters used to identify L. sericata and L. cuprina were reviewed, and then scored and tested using ...
Palmer Emma - - 2013
Chromosomal microarray (CMA) is the first-line diagnostic test for individuals with intellectual disability, autism, or multiple congenital anomalies, with a 10-20% diagnostic yield. An ongoing challenge for the clinician and laboratory scientist is the interpretation of variants of uncertain significance (VOUS)-usually rare, unreported genetic variants. Laboratories differ in their threshold ...
Pereira C S A - - 2013
Understanding the mechanisms underlying diversification and speciation by introgressive hybridization is currently one of the major challenges in evolutionary biology. Here, the analysis of hybridization between two pairs of Iberian Leuciscinae provided new data on independent hybrid zones involving Achondrostoma oligolepis (AOL) and Pseudochondrostoma duriense (PDU), and confirmed the occurrence ...
Said Joseph I - - 2013
The study of quantitative trait loci (QTL) in cotton (Gossypium spp.) is focused on traits of agricultural significance. Previous studies have identified a plethora of QTL attributed to fiber quality, disease and pest resistance, branch number, seed quality and yield and yield related traits, drought tolerance, and morphological traits. However, ...
Wang Ling - - 2013
Seed dormancy (SD) is an important agronomic trait affecting crop yield and quality. In this study, one rice population of recombinant inbred lines (RILs) was used to determine the genetic characteristics of SD at the early (4 weeks after heading), middle (5 weeks after heading) and late (6 weeks after heading) development stages. ...
Bojesen S E - - 2013
Telomeres are the tips of chromosomes and consist of proteins and hexanucleotide tandem repeats of DNA. The DNA repeats are shortened at each mitotic division of normal cells, and the telomere length chronicles how many divisions the cell has undergone. Thus, telomere length is a marker of fundamental biological pathways. ...
Kodavali Chowdari V - - 2013
Associations between human leukocyte antigen (HLA) polymorphisms on chromosome 6p and schizophrenia (SZ) risk have been evaluated for over five decades. Numerous case-control studies from the candidate gene era analyzed moderately sized samples and reported nominally significant associations with several loci in the HLA region (sample sizes, n = 100-400). The risk ...
Dou Quanwen - - 2013
The genome compositions and genetic relationships of seven species of Kengyilia were assessed using a sequential fluorescence in situ hybridization (FISH) and genomic in situ hybridization (GISH) technique. Five species, K. kokonorica, K. rigidula, K. hirsuta, K. grandiglumis, and K. thoroldiana, are native to Qinghai (China). The other two, K. ...
Hill William G - - 2013
Determination of degree of relationship has traditionally been undertaken using genotypic data on individual loci, typically assumed to be independent. With dense marker data as now available it is possible to identify the regions of the genome shared identical by descent (ibd). This information can be used to determine pedigree ...
McClosky Benjamin - - 2013
Recombination is a requirement for response to selection, but researchers still debate whether increasing recombination beyond normal levels will result in significant gains in short-term selection. We tested this hypothesis, in the context of plant breeding, through a series of simulation experiments comparing short-term selection response (≤20 cycles) between populations ...
Currall Benjamin B - - 2013
It has been known for several decades that genetic variation involving changes to chromosomal structure (i.e., structural variants) can contribute to disease; however this relationship has been brought into acute focus in recent years largely based on innovative new genomics approaches and technology. Structural variants (SVs) arise from improperly repaired ...
Baugher Joseph D - - 2013
BACKGROUND: Mosaic somatic alterations are present in all multi-cellular organisms, but the physiological effects of low-level mosaicism are largely unknown. Most mosaic alterations remain undetectable with current analytical approaches, although the presence of such alterations is increasingly implicated as causative for disease. RESULTS: Here, we present the Parent-of-Origin-based Detection (POD) ...
Lindner K - - 2013
Two hybrids between the monkey goby Neogobius fluviatilis and the round goby Neogobius melanostomus from the Rhine River were identified by genotyping and morphological comparison. These are the first records of goby-hybrids outside the parent species' native ranges worldwide.
Arnold Lesley M LM Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, Ohio 44106, USA. - - 2013
Familial aggregation of fibromyalgia has been increasingly recognized. The goal of this study was to conduct a genome-wide linkage scan to identify susceptibility loci for fibromyalgia. We genotyped members of 116 families from the Fibromyalgia Family Study and performed a model-free genome-wide linkage analysis of fibromyalgia with 341 microsatellite markers, ...
Havelka M - - 2013
Polyploidization has played an important role in vertebrate evolution. Acipenseridae bring clear examples of polyploidy ancestry and, also, polyploidization seems to be an ongoing process in these fishes. In the present study, the genetic origin of six triploid specimens morphologically determined as Acipenser ruthenus from commercial aquaculture was analyzed using ...
McIntosh J Richard - - 2013
Interfaces between spindle microtubules and kinetochores were examined in diverse species by electron tomography and image analysis. Overall structures were conserved in a mammal, an alga, a nematode, and two kinds of yeasts; all lacked dense outer plates, and most kinetochore microtubule ends flared into curved protofilaments that were connected ...
Pandey Garima - - 2013
The availability of well-validated informative co-dominant microsatellite markers and saturated genetic linkage map has been limited in foxtail millet (Setaria italica L.). In view of this, we conducted a genome-wide analysis and identified 28 342 microsatellite repeat-motifs spanning 405.3 Mb of foxtail millet genome. The trinucleotide repeats (∼48%) was prevalent ...
Jeffery Nicholas W - - 2013
The Onychophora (velvet worms) represents a small group of invertebrates (~180 valid species), which is commonly united with Tardigrada and Arthropoda in a clade called Panarthropoda. As with the majority of invertebrate taxa, genome size data are very limited for the Onychophora, with only one previously published estimate. Here we ...
Pinto Nádia - - 2013
In paternity testing the informativeness of genetic markers is traditionally measured through the probability of finding, in randomly chosen individuals, inconsistencies with parent to child Mendelian rules of transmission. This statistic, called power of exclusion (PE), paternal exclusion chance or probability, can be defined for duos (mother not typed) or ...
Rohlfs Rori V - - 2013
We investigate the consequences of adopting the criteria used by the state of California, as described by Myers et al. (2011), for conducting familial searches. We carried out a simulation study of randomly generated profiles of related and unrelated individuals with 13-locus CODIS genotypes and YFiler® Y-chromosome haplotypes, on which ...
Haus Tanja - - 2013
Introgressive hybridization may cause substantial discordances among phylogenies based on different genetic markers. Such discordances have been found in diverse mammal species including primates. A recent study of mitochondrial DNA (mtDNA) revealed several poly- and paraphyletic relationships in African green monkeys (Chlorocebus), suggesting contemporary and/or ancient introgressive hybridization among almost ...
Gao Fan F Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles, CA 90089, - - 2013
Circular chromosome conformation capture, when coupled with next-generation sequencing (4C-Seq), can be used to identify genome-wide interaction of a given locus (a "bait" sequence) with all of its interacting partners. Conventional 4C approaches used restriction enzyme digestion to fragment chromatin, and recently sonication approach was also applied for this purpose. ...
Snow Neil N Department of Biology, Pittsburg State University, Pittsburg, KS 66762 - - 2013
Disakisperma Steud. is a genus of four predominantly perennial C4 (NAD-ME) species in the Americas, Africa, and Asia. Its species previously were treated in Eleusine, Eragrostis, Coelachyrum, Cypholepis, Leptochloa, or Diplachne by nearly all authors.It includes the widespread North and South American amphitropical disjunct Disakisperma dubium (type of the genus), ...
Romano Gal Hagit GH Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Tel Aviv, Israel ; Blavatnik School of Computer Science, Tel Aviv University, Tel Aviv, Israel ; Department of Biological Sciences, Columbia University, New York, New York, United States of - - 2013
Telomeres protect the chromosome ends from degradation and play crucial roles in cellular aging and disease. Recent studies have additionally found a correlation between psychological stress, telomere length, and health outcome in humans. However, studies have not yet explored the causal relationship between stress and telomere length, or the molecular ...
Wientjes Yvonne C J YC Animal Breeding and Genomics Centre, Wageningen UR Livestock Research, 8200 AB Lelystad, The Netherlands. - - 2013
Although the concept of genomic selection relies on linkage disequilibrium (LD) between quantitative trait loci and markers, reliability of genomic predictions is strongly influenced by family relationships. In this study, we investigated the effects of LD and family relationships on reliability of genomic predictions and the potential of deterministic formulas ...
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