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Wang Lu L Department of Biostatistics, University of Michigan, 1415 Washington Heights, Ann Arbor, MI 48109, - - 2014
In many biomedical studies, identifying effects of covariate interactions on survival is a major goal. Important examples are treatment-subgroup interactions in clinical trials, and gene-gene or gene-environment interactions in genomic studies. A common problem when implementing a variable selection algorithm in such settings is the requirement that the model must ...
Parker Geoff A GA Institute of Integrative Biology, University of Liverpool, Liverpool L69 7ZB, UK - - 2014
Both gamete competition and gamete limitation can generate anisogamy from ancestral isogamy, and both sperm competition (SC) and sperm limitation (SL) can increase sperm numbers. Here, we compare the marginal benefits due to these two components at any given population level of sperm production using the risk and intensity models ...
Schläpfer Markus M Senseable City Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA Santa Fe Institute, Santa Fe, NM 87501, USA - - 2014
The size of cities is known to play a fundamental role in social and economic life. Yet, its relation to the structure of the underlying network of human interactions has not been investigated empirically in detail. In this paper, we map society-wide communication networks to the urban areas of two ...
Blue Elizabeth M EM Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, Washington, United States of - - 2014
When analyzing family data, we dream of perfectly informative data, even whole-genome sequences (WGSs) for all family members. Reality intervenes, and we find that next-generation sequencing (NGS) data have errors and are often too expensive or impossible to collect on everyone. The Genetic Analysis Workshop 18 working groups on quality ...
Ziegler Andreas A Institut für Medizinische Biometrie und Statistik, Universität zu Lübeck, Universitätsklinikum Schleswig-Holstein, Campus Lübeck, Lübeck, Germany; Center for Clinical Trials, University of Lübeck, Lübeck, - - 2014
High-throughput sequencing data can be used to predict phenotypes from genotypes, and this corresponds to establishing a prognostic model. In extended pedigrees the relatedness of subjects provides additional information so that genetic values, fixed or random genetic components, and heritability can be estimated. At the Genetic Analysis Workshop 18, the ...
Ghosh Saurabh S Human Genetics Unit, Indian Statistical Institute, Kolkata, - - 2014
Our working group studied methods for joint analyses of multiple phenotypes using the data provided by Genetic Analysis Workshop 18. Two data sets were available: one containing genotypes obtained from a real human whole-genome sequencing study along with longitudinal measurements on systolic and diastolic blood pressure, age, sex, medication use, ...
Wu Zheyang Z Department of Mathematical Sciences, Worcester Polytechnic Institute, Worcester, Massachusetts, United States of - - 2014
The analysis of whole-genome sequence (WGS) data using longitudinal phenotypes offers a potentially rich resource for the examination of the genetic variants and their covariates that affect complex phenotypes over time. We summarize eight contributions to the Genetic Analysis Workshop 18, which applied a diverse array of statistical genetic methods ...
Lu Ake Tzu-Hui AT Department of Human Genetics, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, United States of - - 2014
Machine learning methods (MLMs), designed to develop models using high-dimensional predictors, have been used to analyze genome-wide genetic and genomic data to predict risks for complex traits. We summarize the results from six contributions to our Genetic Analysis Workshop 18 working group; these investigators applied MLMs and data mining to ...
Green Jonathan P JP School of Life Sciences, University of Sussex, John Maynard Smith Building, Brighton BN1 9QG, UK - - 2014
Remarkable variation exists in the distribution of reproduction (skew) among members of cooperatively breeding groups, both within and between species. Reproductive skew theory has provided an important framework for understanding this variation. In the primitively eusocial Hymenoptera, two models have been routinely tested: concessions models, which assume complete control of ...
Bonandin L L Dipartimento di Scienze Biologiche, Geologiche e Ambientali, Università di Bologna, Bologna, - - 2014
Theoretical and empirical studies have shown differential management of transposable elements in organisms with different reproductive strategies. To investigate this issue, we analysed the R2 retroelement structure and variability in parthenogenetic and bisexual populations of Bacillus rossius stick insects, as well as insertions inheritance in the offspring of parthenogenetic isolates ...
Alcaraz Nicolas - - 2014
BackgroundOver the last decade network enrichment analysis has become popular in computational systems biology to elucidate aberrant network modules. Traditionally, these approaches focus on combining gene expression data with protein-protein interaction (PPI) networks. Nowadays, the so-called omics technologies allow for inclusion of many more data sets, e.g. protein phosphorylation or ...
Bai Lu L a Jiangsu Key Laboratory of Urban ITS, Jiangsu Collaborative Innovation Center of Modern Urban Traffic Technologies , Southeast University, Si Pai Lou #2 , Nanjing , China , 210096 , Tel: +86-13813393131 , Email: - - 2014
ABSTRACT Objective: The primary objective of this study was to compare the risky behaviors of e-bike, e-scooter and bicycle riders as they were crossing signalized intersections. Methods: Pearson's Chi-square test was used to identify if there were significant differences in the risky behaviors among e-bike, e-scooter and bicycle riders. Binary ...
Yeo Jiho J a The Cho Chun Shik Graduate School for Green Transportation, Korea Advanced Institute of Science and Technology , N22, 209 Daehak-ro, Yuseong-gu , Daejeon 305-701 , Republic of Korea , +82-42-350-1284 , - - 2014
Abstract Objective: Previous research suggests that urban sprawl increases auto-dependency and that excessive auto use increases the risk of traffic fatalities. This indirect effect of urban sprawl on traffic fatalities is compared with the non-VMT-involved direct effect of sprawl on fatalities. Methods: We conducted a path analysis to examine the ...
Wang Minxian M Department of Computational Regulatory Genomics, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Chinese Academy of Sciences, Shanghai, - - 2014
Studies of natural selection, followed by functional validation, are shedding light on understanding of genetic mechanisms underlying human evolution and adaptation. Classic methods for detecting selection, such as the integrated haplotype score (iHS) and Fay&Wu's H statistic, are useful for candidate gene searching underlying positive selection. These methods, however, have ...
Moran Tracy E TE Erikson Institute, 451 N. LaSalle St, Chicago, IL, 60654, USA, - - 2014
This study represents the second validation phase of the Postpartum Worry Scale-Revised (PWS-R). As the PWS-R includes items tapping infant health and development concerns, we compare its psychometric properties with a sample of NICU mothers and the online sample used in the initial validation. We conduct a confirmatory factor analysis ...
Meyer Rika M L RM Department of Anesthesiology and Critical Care Medicine, Children's Hospital Los Angeles, 4650 Sunset Blvd. MS#12, Los Angeles, CA, 90027, USA, - - 2014
Given the consistent growth of the Latino population in the United States, there is a critical need for validated Spanish measures to assess posttraumatic stress disorder (PTSD) symptoms in children. The current study examines the psychometric properties of the Child PTSD Symptom Scale (CPSS). We examined 259 children (8-17 years) who ...
Williams Bob B Senior Lecturer, Department of Psychology, University of Durham, Durham, - - 2014
In this study the independence of the scales/items in the Health of the Nation Outcome Scales (HoNOS) was empirically investigated. Parallel analysis using random column permutation and bootstrapping were used to compare the factor structure, intercorrelations and Cronbach's alpha from the original HoNOS study and also recently collected HoNOS ratings. ...
Gérin Stéphanie - - 2014
BackgroundIn photosynthetic organisms, the influence of light, carbon and inorganic nitrogen sources on the cellular bioenergetics has extensively been studied independently, but little information is available on the cumulative effects of these factors. Here, sequential statistical analyses based on design of experiments (DOE) coupled to standard least squares multiple regression ...
Yan Huihuang - - 2014
Chromatin immunoprecipitation (ChIP) followed by next-generation sequencing (ChIP-Seq) has been widely used to identify genomic loci of transcription factor (TF) binding and histone modifications. ChIP-Seq data analysis involves multiple steps from read mapping and peak calling to data integration and interpretation. It remains challenging and time-consuming to process large amounts ...
Kienberger Stefan - - 2014
Despite efforts in eradication and control, malaria remains a global challenge, particularly affecting vulnerable groups. Despite the recession in malaria cases, previously malaria free areas are increasingly confronted with epidemics as a result of changing environmental and socioeconomic conditions. Next to modeling transmission intensities and probabilities, integrated spatial methods targeting ...
Tu Yaqin Y The Center for Biomedical Research, Tongji Hospital; Department of Biochemistry and Molecular Biology, Tongji Medical - - 2014
We conducted a case/control study to assess the impact of two SNPs, rs2241766 and rs1501299 within the ADIPOQ gene, on type 2 diabetes (T2D) susceptibility in a Chinese Han dataset (741 cases and 902 controls). SNP rs2241766 was found significantly associated with T2D risk in the additive model, dominant model ...
Lange-Morales Karen K a School of Industrial Design - MIMAPRO Research Group , Universidad Nacional de Colombia , Bogotá , - - 2014
In this paper, we analyse two approaches that attempt to address how a human factors and ergonomics (HFE) perspective can contribute to the sustainability of the human race. We outline the principles, purposes and fields of application of ergoecology and green ergonomics, and thereafter deal with their context of emergence, ...
Vranic Branko Z BZ Department of Pharmaceutical Sciences, University of Basel , Basel , Switzerland - - 2014
Abstract Near-infrared spectroscopy (NIRS) is used in the pharmaceutical industry for monitoring drug content during the tablet manufacturing process. It is of critical importance to understand the effect of process factors on NIRS performance. Design of Experiments (DoE) methodology was applied in this work for the systematic study of the ...
Zhang Fangyuan F 0000000335019150 Department of Statistics, The Ohio State University, Columbus, OH, - - 2014
Imprinting effects can lead to parent-of-origin patterns in complex human diseases. For a diallelic marker locus, Pedigree Parental-Asymmetry Test (PPAT) and its extension MCPPAT using pedigrees allowing for missing genotypes are simple and powerful for detecting imprinting effects. However, these approaches only take affected offspring into consideration, thus not making ...
Li Xiaoshan X Key Lab of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China; University of Chinese Academy of Sciences, Beijing, China; School of Psychology, Jiangxi Normal University, Nanchang, - - 2014
The relationship between a leader's personality and his team's performance has been established in organisational research, but the underlying process and mechanism responsible for this effect have not been fully explored. Both the traditional multiple linear regression and the multilevel structural equation model approaches were used in this study to ...
Shepard Ron R Chemical Sciences and Engineering Division, Argonne National Laboratory, Argonne, Illinois 60439, - - 2014
Practical algorithms are presented for the parameterization of orthogonal matrices Q ∈ [Formula: see text] (m×n) in terms of the minimal number of essential parameters {φ}. Both square n = m and rectangular n < m situations are examined. Two separate kinds of parameterizations are considered, one in which the ...
Lavigne John V JV Department of Child and Adolescent Psychiatry (#10), Ann & Robert H. Lurie Children's Hospital of Chicago, 225 East Chicago Avenue, Chicago, IL, 60611, USA, - - 2014
Identifying the latent structure of Oppositional Defiant Disorder (ODD) may have important clinical and research implications. The present study compared existing dimensional models of ODD for model fit and examined the metric and scalar invariance of the best-fitting model. Study participants were a diverse (38.8 % minority, 49.1 % boys) community sample ...
Korukcu Oznur O a Department of Obstetrics & Gynaecology Nursing , School of Nursing, Akdeniz University , Antalya , - - 2014
Abstract Examining the fear of delivery after childbirth is important. The author's aim is to examine the overall psychometric quality of the Wijma Delivery Expectancy/Experience Questionnaire version B. Reliability and validity of the instrument were evaluated via reliability analysis, exploratory and confirmatory factor analyses, and multidimensional subscore estimation. A six-factor ...
Bland Lucie M LM Institute of Zoology, Zoological Society of London, Regent's Park, London NW1 4RY, United Kingdom; Division of Biology, Imperial College London, Silwood Park, Ascot, SL5 7PY, United Kingdom. - - 2014
There is little appreciation of the level of extinction risk faced by one-sixth of the over 65,000 species assessed by the International Union for Conservation of Nature. Determining the status of these data-deficient (DD) species is essential to developing an accurate picture of global biodiversity and identifying potentially threatened DD ...
Neidhart Johannes J University of - - 2014
Much of the current theory of adaptation is based on Gillespie's mutational landscape model (MLM), which assumes that the fitness values of genotypes linked by single mutational steps are independent random variables. On the other hand, a growing body of empirical evidence shows that real fitness landscapes, while possessing a ...
Su G G Center for Quantitative Genetics and Genomics, Department of Molecular Biology and Genetics, Aarhus University, DK-8830 Tjele, Denmark. Electronic address: - - 2014
Various models have been used for genomic prediction. Bayesian variable selection models often predict more accurate genomic breeding values than genomic BLUP (GBLUP), but GBLUP is generally preferred for routine genomic evaluations because of low computational demand. The objective of this study was to achieve the benefits of both models ...
Roshyara Nab - - 2014
BackgroundImputation of partially missing or unobserved genotypes is an indispensable tool for SNP data analyses. However, research and understanding of the impact of initial SNP-data quality control on imputation results is still limited. In this paper, we aim to evaluate the effect of different strategies of pre-imputation quality filtering on ...
Leung Tiana T School of Optometry, University of California, Berkeley, Clinical Research Center, 360 Minor Hall, Berkeley, CA, 94720, United - - 2014
Purpose: To investigate factors of ethnic, gender, age, and diurnal variation on human corneal epithelial permeability. Methods: Data of corneal epithelial permeability to sodium fluorescein (Pdc) were collected from 374 non-contact lens wearers at various times after awakening throughout the day. Mixed-effect models were developed to investigate the association between ...
Weinberger Joel - - 2014
The dichotomy between what has been termed empirically supported treatments (EST) and common factors (CF) is false and counterproductive. Neither has a monopoly on empirical truth. The term nonspecific is unproductive and misleading. Specified versus nonspecified is more empirically correct. Assumptions of the EST and CF approaches are questionable. Common ...
Molenaar Dylan D University of Amsterdam, The - - 2014
We show how the hierarchical model for responses and response times as developed by van der Linden (2007), Fox, Klein Entink, and van der Linden (2007), Klein Entink, Fox, and van der Linden (2009), and Glas and van der Linden (2010) can be simplified to a generalized linear factor model ...
Malhotra Rahul R Health Services and Systems Research, Duke-NUS Graduate Medical School, Singapore; Duke Global Health Institute, Duke University, Durham, North Carolina, - - 2014
To determine the extent of interviewer error on the Short Portable Mental Status Questionnaire (SPMSQ), the association between interviewer-level variables and SPMSQ score, compare the prevalence of SPMSQ cognitive status categories before and after correction for interviewer error, and identify SPMSQ items prone to interviewer error. Data of 4542 older ...
Umićević Mirkov Maša M Department of Human Genetics, Radboud University Medical Center, Nijmegen, The - - 2014
Pharmacogenetic studies of tumour necrosis factor inhibitors (TNFi) response in patients with rheumatoid arthritis (RA) have largely relied on the changes in complex disease scores, such as disease activity score 28 (DAS28), as a measure of treatment response. It is expected that genetic architecture of such complex score is heterogeneous ...
Knuiman Matthew W - - 2014
The purpose of the present analysis was to use longitudinal data collected over 7 years (from 4 surveys) in the Residential Environments (RESIDE) Study (Perth, Australia, 2003-2012) to more carefully examine the relationship of neighborhood walkability and destination accessibility with walking for transportation that has been seen in many cross-sectional ...
Dørum Guro G Department of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, Aas, Norway, - - 2014
Allelic dropout in relationship problems may commonly appear in areas such as disaster victim identification and the identification of missing persons. If dropout is not accounted for, the results may be incorrect interpretation of profiles, loss of valuable information and biased results. In this paper, we explore different models for ...
Bouba Fanta F UMI 209, UMMISCO-UCAD, Dakar, Senegal, - - 2014
The Rift Valley fever (RVF), which first appeared in Kenya in 1912, is an anthropozoonosis widespread in tropical areas. In Senegal, it is particularly felt in the Ferlo area where a strong presence of ponds shared by humans, cattle and vectors is noted. As part of the studies carried out ...
Noordhof Arjen A University Medical Center Groningen, Groningen, Netherlands, - - 2014
Problems associated with Autism Spectrum Disorder (ASD) occur frequently in the general population and often co-occur with problems in other domains of psychopathology. In the research presented here these co-occurrence patterns were investigated by integrating a dimensional approach to ASDs into the more general dimensional framework of internalizing and externalizing ...
Dornburg Alex - - 2014
BackgroundDiscordance among individual molecular age estimates, or between molecular age estimates and the fossil record, is observed in many clades across the Tree of Life. This discordance is attributed to a variety of variables including calibration age uncertainty, calibration placement, nucleotide substitution rate heterogeneity, or the specified molecular clock model. ...
Yet Barbaros B School of Electronic Engineering and Computer Science, Queen Mary University of London, UK. Electronic address: - - 2014
Complex clinical decisions require the decision maker to evaluate multiple factors that may interact with each other. Many clinical studies, however, report 'univariate' relations between a single factor and outcome. Such univariate statistics are often insufficient to provide useful support for complex clinical decisions even when they are pooled using ...
Daou Hoda - - 2014
A novel technique for Electroencephalogram (EEG) compression is proposed in this article. This technique models the intrinsic dependency inherent between the different EEG channels. It is based on methods borrowed from dipole fitting that is usually used in order to find a solution to the classic problems in EEG analysis: ...
Forutan M M Department of Animal Science, College of Agriculture, Isfahan University of Technology, Isfahan, - - 2014
Calf and heifer survival are important traits in dairy cattle affecting profitability. This study was carried out to estimate genetic parameters of survival traits in female calves at different age periods, until nearly the first calving. Records of 49 583 female calves born during 1998 and 2009 were considered in five ...
Ho Paul M PM a Melbourne School of Psychological Sciences , The University of Melbourne , - - 2014
Feelings of pleasure felt in the moment of goal attainment (consummatory pleasure) are thought to be dissociable from feelings of desire connected with the motivated approach of goals (anticipatory pleasure). The Temporal Experience of Pleasure Scales (TEPS; Gard, Gard, Kring, & John, 2006) was developed to assess individual differences in ...
Chifman Julia J Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, NC, - - 2014
Increasing attention has been devoted to estimation of species-level phylogenetic relationships under the coalescent model. However, existing methods either use summary statistics (gene trees) to carry out estimation, ignoring an important source of variability in the estimates, or involve computationally-intensive Bayesian Markov chain Monte Carlo algorithms that don't scale well ...
Sara Ceccarelli F F University of Basel, Biogeography Research Group, Department of Environmental Sciences, Basel 4056, - - 2014
The Eastern Afromontane Region (EAR) contains numerous endemic species, yet its reptile diversity remains relatively poorly understood. We used molecular data to examine species diversity of the Sub-Saharan chameleon genus Trioceros. In particular, we focus on establishing species boundaries for taxa with disjunct distributions across the fragmented mountains of the ...
Xia Jie J The Second Xiangya Hospital of Central South University, P.R. - - 2014
This study aimed to validate the Chinese version of the Optimism and Pessimism Scale in a sample of 730 adult Chinese individuals. Confirmatory factor analyses confirmed the bidimensionality of the scale with two factors, optimism and pessimism. The total scale and optimism and pessimism factors demonstrated satisfactory reliability and validity. ...
Manap Norpadzlihatun N Faculty of Technology Management and Business Universiti Tun Hussein Onn Malaysia 86400 Parit Raja, Batu Pahat Johor, Malaysia; Centre for Environmental Policy, Imperial College London, United Kingdom. Electronic address: - - 2014
The aim of this study was to develop a risk-based decision-making framework for the selection of sediment dredging option. Descriptions using case studies of the newly integrated, holistic and staged framework were followed. The first stage utilized the historical dredging monitoring data and the contamination level in media data into ...
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