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Vlaanderen Jelle J IRAS Utrecht University, Utrecht, The - - 2014
Due to their interrelatedness, modelling independent effects of intensity, duration, and time since exposure on disease risk is complex. The indiscriminate use of the cumulative exposure metric (product of intensity and duration of exposure) might bias reported associations between exposure to hazardous agents and disease risk. We explored the use ...
Richardson David D Department of Epidemiology, Chapel Hill, NC, - - 2014
When an exposure is protracted or repeated over time, questions arise regarding variation in the effect for different temporal patterns of exposure. We review approaches to describe variation in an exposure's effect as a function of age-at-exposure, time-since-exposure, and exposure rate. These models implicitly assume that the effect of an ...
Chadeau-Hyam Marc M Imperial College, London, - - 2014
Chronic diseases are usually slow-developing condition and their risk may result from both long-term exposure and successive exposure increments, hence calling for models accounting for dynamics of exposure and disease progression. Discrete compartmental models are defined by a set of ordered states (compartments) reflecting the health status, and can be ...
Pesch Beate B Institute for Prevention and Occupational Medicine of the German Social Accident Insurance - Institute of Ruhr University Bochum (IPA), Bochum, - - 2014
To assess level and trend of exposure to hexavalent chromium (Cr(VI)) in chromium-exposed occupations for the estimation of lung cancer risks in community-based studies. This analysis was based on 3666 personal measurements and auxiliary data compiled in the German MEGA database from 1988-2009. Cr(VI) was determined spectrophotometrically at 540 nm ...
McLean David D Massey University, Wellington, New - - 2014
Significant excess risks of lung cancer and haematologic neoplasms have been observed in slaughterhouse workers in eight New Zealand studies, and numerous studies conducted elsewhere. No specific causal agents have been identified, although a biological aetiology is suggested as the risk is highest in those areas where workers are exposed ...
Scott Laura L University of Minnesota School of Public Health, Minneapolis, MN, - - 2014
To quantify the effect of exposure and disease misclassification on the odds ratio (OR) for ischaemic heart disease (IHD) mortality in a retrospective cohort study of trichlorophenol workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Exposure and disease classification parameters were defined using specificity and sensitivity values either reported in the peer-reviewed literature ...
Fritschi Lin L The University of Western Australia, Perth, - - 2014
Good occupational health policy requires an overall understanding of the proportion of the working population who are exposed to hazards at work. This is difficult to estimate when nearly three-quarters of the workforce are in small and medium sized companies and so not easily surveyed or monitored. We are undertaking ...
Demers Paul P Occupational Cancer Research Centre, Toronto, CanadaUniversity of Toronto, Toronto, - - 2014
In recent years, several new burden projects have been initiated with increased methodological sophistication. Previous studies have varied with respect to methods used to identify the prevalence and relevant levels of exposure, but many have relied on CAREX estimates. In this presentation, we will focus on the impact of incorporating ...
Pronk Anjoeka A TNO, Zeist, The - - 2014
A multidimensional intervention aimed at reducing silica exposure in the Dutch construction industry was performed. The objective of this study was to assess the effect of the achieved reduction in exposure on the burden of chronic obstructive pulmonary disease (COPD) in construction workers. The intervention aimed at technical, organisational and ...
Bernardes Kionna K Federal University of Bahia, Salvador, Bahia, - - 2014
The aim of this study was to evaluate the dimensions of the JCQ among healthcare workers A validation study with 3055 health workers was conducted. Factor analysis was employed through the principal components method. For extraction of factors, parallel analysis was performed using the Monte-Carlo simulation. For the technique of ...
Danacı Burçin B Department of Physics Engineering, Istanbul Technical University, Maslak, Istanbul, - - 2014
Topological features of gene regulatory networks can be successfully reproduced by a model population evolving under selection for short dynamical attractors. The evolved population of networks exhibit motif statistics, summarized by significance profiles, which closely match those of E. coli, S. cerevsiae, and B. subtilis, in such features as the ...
Kern Elisandra Lurdes EL Embrapa Gado de Leite, Eugênio do Nascimento Street, 610, Juiz de Fora, MG 36038-330, Brazil - - 2014
In this study we aimed to evaluate the reduction in dimensionality of 20 linear type traits and more final score in 14,943 Holstein cows in Brazil using factor analysis, and indicate their relationship with longevity and 305 d first lactation milk production. Low partial correlations (-0.19 to 0.38), the medium ...
Nikolic Natacha N IFREMER La Réunion Le Port, - - 2014
Understanding and predicting population abundance is a major challenge confronting scientists. Several genetic models have been developed using microsatellite markers to estimate the present and ancestral effective population sizes. However, to get an overview on the evolution of population requires that past fluctuation of population size be traceable. To address ...
Hökerberg Yara Hahr Marques YH Laboratório de Epidemiologia Clínica, Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, - - 2014
OBJECTIVE To evaluate the cross-cultural validity of the Demand-Control Questionnaire, comparing the original Swedish questionnaire with the Brazilian version. METHODS We compared data from 362 Swedish and 399 Brazilian health workers. Confirmatory and exploratory factor analyses were performed to test structural validity, using the robust weighted least squares mean and ...
Yang Frances M FM Department of Biostatistics and Epidemiology, Georgia Regents University, Medical College of Georgia, Augusta, GA, United - - 2014
Item response theory (IRT) is an important method of assessing the validity of measurement scales that is underutilized in the field of psychiatry. IRT describes the relationship between a latent trait (e.g., the construct that the scale proposes to assess), the properties of the items in the scale, and respondents' ...
Yazdani-Charati Jamshid J Department of Biostatistics, Health Sciences Research Center, Faculty of Health, Mazandaran University of Medical Sciences, Sari, - - 2014
Road safety and traffic accidents change in time and space. Although, time variations have always been considered the subject being focused by researchers, the effect of spatial correlation and spatial components on the risk of accident have been less investigated. Due to its specific geographical position, Mazandaran Province is one ...
Lusczakoski Kathryn Kd KK Accelrys, Lafayette, CO, - - 2014
As the need for recovery-oriented outcomes increases, it is critical to understand how numeric recovery scores are developed. In the current article, the modern Rasch modeling techniques were applied to establish numeric scores of consumers' perceptions of recovery. A sample of 1,973 adult consumers at a community-based mental health center ...
Constable George W A GW Theoretical Physics Division, School of Physics and Astronomy, The University of Manchester, Manchester M13 9PL, UK. Electronic address: - - 2014
We analyse a model consisting of a population of individuals which is subdivided into a finite set of demes, each of which has a fixed but differing number of individuals. The individuals can reproduce, die and migrate between the demes according to an arbitrary migration network. They are haploid, with ...
Xiao Changji C Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, - - 2014
•An improved YASSO model is proposed by considering residual spatial autocorrelation.•Model prediction errors are minimised using GIS data at the appropriate spatial scale.•Topographical factors describe 24-49% of variation in soil carbon.
Tenailleau Quentin M QM Laboratoire Chrono-environnement UMR6249 Centre National de la Recherche Scientifique/Université de Franche-Comté, Besançon, - - 2014
Environmental epidemiological studies rely on the quantification of the exposure level in a surface defined as the subject's exposure area. For residential exposure, this area is often the subject's neighborhood. However, the variability of the size and nature of the neighborhoods makes comparison of the findings across studies difficult. This ...
Jacobsen M W MW Department of Bioscience, Aarhus University, Aarhus C, - - 2014
Processes leading to speciation in oceanic environments without obvious physical barriers remain poorly known. European and American eel (Anguilla anguilla and A. rostrata) spawn in partial sympatry in the Sargasso Sea. Larvae are advected by the Gulf Stream and other currents towards the European/North African and North American coasts, respectively. ...
Maruki Takahiro T Indiana University - - 2014
Rapidly improving sequencing technologies provide unprecedented opportunities for analyzing genome-wide patterns of polymorphisms. In particular, they have great potential for linkage-disequilibrium analyses on both global and local genetic scales, which will substantially improve our ability to derive evolutionary inferences. However, there are some difficulties with analyzing high-throughput sequencing data, including ...
Flori Laurence L CIRAD, UMR INTERTRYP, F34398, Montpellier, France; INRA, UMR 1313 GABI, F78350, Jouy-en-Josas, - - 2014
Understanding the adaptive response to environmental fluctuations represents a central issue in evolutionary biology. Population admixture between divergent ancestries has often been considered as an efficient short-term adaptation strategy. Cattle populations from the West African Bos taurus x Bos indicus hybrid zone represent a valuable resource to characterize the effect ...
Seixas Flávio Luiz FL Institute of Computing, Federal Fluminense University, Rua Passo da Pátria, 156, Niterói, RJ 24210-240, Brazil. Electronic address: - - 2014
Population aging has been occurring as a global phenomenon with heterogeneous consequences in both developed and developing countries. Neurodegenerative diseases, such as Alzheimer׳s Disease (AD), have high prevalence in the elderly population. Early diagnosis of this type of disease allows early treatment and improves patient quality of life. This paper ...
Fujimoto M - - 2014
Error correction is an important step in increasing the quality of next-generation sequencing data for downstream analysis and use. Polymorphic datasets are a challenge for many bioinformatic software packages that are designed for or assume homozygosity of an input dataset. This assumption ignores the true genomic composition of many organisms ...
Redelings Benjamin B Biology Department, Duke UniversityNational Evolutionary Synthesis Center - - 2014
Current estimates of diversifying positive selection rely on first having an accurate multiple sequence alignment. Simulation studies have shown that under biologically plausible conditions, relying on a single estimate of the alignment from commonly used alignment software can lead to unacceptably high false positive rates in detecting diversifying positive selection. ...
Jacobsen Grant D - - 2014
This paper provides the first estimates of end-use specific emissions factors, which are estimates of the amount of a pollutant that is emitted when a unit of electricity is generated to meet demand from a specific end-use. In particular, this paper provides estimates of emissions factors for space cooling and ...
Takeda Akiko A Department of Mathematical Informatics, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan. Electronic address: - - 2014
We propose a unified machine learning model (UMLM) for two-class classification, regression and outlier (or novelty) detection via a robust optimization approach. The model embraces various machine learning models such as support vector machine-based and minimax probability machine-based classification and regression models. The unified framework makes it possible to compare ...
Xie Haoran H Department of Computer Science, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong Special Administrative - - 2014
In the era of big data, collaborative tagging (a.k.a. folksonomy) systems have proliferated as a consequence of the growth of Web 2.0 communities. Constructing user profiles from folksonomy systems is useful for many applications such as personalized search and recommender systems. The identification of latent user communities is one way ...
Gomez Rapson R Federation University, Australia. Electronic address: - - 2014
We report a meta-analysis of up to 40 data sets that examined the personality dimensions in the Five-Factor Model (FFM) and the integrated Five-Factor Model (IFFM) in relation to ADHD symptom domains of inattention (IA) and hyperactivity/impulsivity (HI). The IFFM incorporated the dimensions of other personality models (in particular, those ...
Lopes Paulo P Universidade Lusófona de Humanidades e Tecnologias, COPELABS, Centro de Estudos em Psicologia Cognitiva e da Aprendizagem, Ares do Pinhal, Portugal. Electronic address: - - 2014
A high degree of self-efficacy is required from drug users if they are to adopt long-term abstinence-maintaining or harm-reducing behaviors. Our objective was to analyze the psychometric quality of the Harm Reduction Self-Efficacy Questionnaire (HRSEQ) with the Rating Scale Model (RSM), an extension of the Rasch Model for polytomous items. ...
AbdelRahman Samir E - - 2014
The aim of this study was to propose an analytical approach to develop high-performing predictive models for congestive heart failure (CHF) readmission using an operational dataset with incomplete records and changing data over time. Our analytical approach involves three steps: pre-processing, systematic model development, and risk factor analysis. For pre-processing, ...
Wang Jinliang J Institute of Zoology, Zoological Society of London, London, NW1 4RY, United - - 2014
Coupled with rapid developments of efficient genetic markers, powerful population genetics methods were proposed to estimate migration rates (m) in natural populations in much broader spatial and temporal scales than the traditional mark-release-recapture (MRR) methods. Highly polymorphic (e.g. microsatellites) and genomic wide (e.g. SNPs) markers provide sufficient information to assign ...
Downs C J CJ *Department of Natural Resources and Environmental Sciences, University of Nevada, Reno, NV 89557, USA; Department of Biological Sciences, North Dakota State University, Fargo, ND 58102, USA - - 2014
Considerable research in ecoimmunology focuses on investigating variation in immune responses and linking this variation to physiological trade-offs, ecological traits, and environmental conditions. Variation in immune responses exists within and among individuals, among populations, and among taxonomic groupings. Understanding how variation and covariation are distributed and how they differ across ...
Davis Brittany A BA MRC Centre for Neuropsychiatric Genetics and Genomics, Neuroscience and Mental Health Research Institute, Cardiff University, Hadyn Ellis Building, Maindy Road, Cardiff, CF24 4HQ, - - 2014
Rodent models are a key factor in the process of translating psychiatric genetics and genomics findings, allowing us to shed light on how risk-genes confer changes in neurobiology by merging different types of data across fields, from behavioural neuroscience to the burgeoning omics (e.g. genomics, epigenomics, proteomics, etc.). Moreover, they ...
Iversen Edwin S - - 2014
Genetic association studies are conducted to discover genetic loci that contribute to an inherited trait, identify the variants behind these associations and ascertain their functional role in determining the phenotype. To date, functional annotations of the genetic variants have rarely played more than an indirect role in assessing evidence for ...
Cai Guanjing - - 2014
Controlling harmful algae blooms (HABs) using microbial algicides is cheap, efficient and environmental-friendly. However, obtaining high yield of algicidal microbes to meet the need of field test is still a big challenge since qualitative and quantitative analysis of algicidal compounds is difficult. In this study, we developed a protocol to ...
Otani Koichi K Department of Psychiatry, Yamagata University School of Medicine, 2-2-2 Iida-Nishi, Yamagata 990-9585, - - 2014
Beck's cognitive theory of depression postulates personality vulnerability factors termed sociotropy and autonomy, which are accompanied by characteristic interpersonal styles. Meanwhile, Bartholomew contends that negative working models of the self and other built through insecure attachment relationships are externalized as distinctive interpersonal styles. The present study examined the relationships of ...
May Sabine S PharmBioTec GmbH, Saarbrücken, - - 2014
The aim of this study was to investigate influencing factors on the dissolution test for powders for pulmonary delivery with USP apparatus 2 (paddle apparatus). We investigated the influence of dose collection method, membrane holder type and the presence of surfactants on the dissolution process. Furthermore, we modeled the in ...
Liu Ruijie - - 2014
SNP genotyping microarrays have revolutionized the study of complex disease. The current range ofcommercially available genotyping products contain extensive catalogues of low frequency and rarevariants. Existing SNP calling algorithms have difficulty dealing with these low frequency variants,as the underlying models rely on each genotype having a reasonable number of observations ...
Choi Sunhwa S Department of Mathematics, Konkuk University, Seoul , 143-701, Republic of Korea, - - 2014
A mathematical control model for the transmission dynamics of tuberculosis (TB) in South Korea is developed on the basis of the reported active-TB and relapse-TB incidence data. In this work, optimal control theory is used to propose optimal TB prevention and control strategy and rearrange the government TB budget for ...
Costa Jane - - 2014
The Triatoma brasiliensis complex is a monophyletic group, comprising three species, one of which includes two subspecific taxa, distributed across 12 Brazilian states, in the caatinga and cerrado biomes. Members of the complex are diverse in terms of epidemiological importance, morphology, biology, ecology, and genetics. Triatoma b. brasiliensis is the ...
Chae Jung-Woo - - 2014
Aim: The objective of the present study was to develop population pharmacokinetic models for olmesartan medoxomil and hydrochlorothiazide and to investigatem the influence of demographic factors on these population pharmacokinetics. Methods: Plasma concentrations of olmesartan medoxomil and hydrochlorothiazide were measured in 41 healthy volunteers enrolled in our bioequivalence study by ...
Sivan Atara A 1 Hong Kong Baptist University, Hong - - 2014
Summary.-This study validated the Chinese version of the Questionnaire on Teacher Interaction (C-QTI) with two samples (ns = 370 and 369) of primary school students in Hong Kong. The 48-item measure had acceptable internal consistency reliability, but the reliability coefficients of four of the scales were too low. The findings ...
Geronimi Elena M C EM a Department of Psychological and Brain Sciences , University of Louisville , Louisville , KY , - - 2014
Despite strong evidence that worry is a verbal process, studies examining linguistic features in individuals with generalised anxiety disorder (GAD) are lacking. The aim of the present study is to investigate language use in individuals with GAD and controls based on GAD and worry theoretical models. More specifically, the degree ...
Li Jia J Department of Public Health Sciences, Henry Ford Health System, Detroit, Michigan, United States of - - 2014
Genome-wide association studies (GWAS) that draw samples from multiple studies with a mixture of relationship structures are becoming more common. Analytical methods exist for using mixed-sample data, but few methods have been proposed for the analysis of genotype-by-environment (G×E) interactions. Using GWAS data from a study of sarcoidosis susceptibility genes ...
Baccini Michela M 1Department of Statistics, University of Florence, Florence, - - 2014
This paper describes the methods used to investigate variations in total alcoholic beverage consumption as related to selected control intervention policies and other socioeconomic factors (unplanned factors) within 12 European countries involved in the AMPHORA project. The analysis presented several critical points: presence of missing values, strong correlation among the ...
Mitteldorf Joshua J Massachusetts Inst of Technology, Dept of EAPS, 654 Carpenter Ln, Philadelphia, PA 19119, USA. - - 2014
Prevailing ideas of how aging evolved are a poor fit with the picture of aging that is developing from genetics labs and breeding experiments. Nevertheless, the community of theorists is reluctant to consider alternate approaches because the differences are profound, calling into question much of the standard methodology of Population ...
Pemberton Mark A MA Systox Ltd, Wilmslow, Cheshire, UK. Electronic address: - - 2014
Acrylic, Poly Methyl Methacrylate (PMMA) based polymers are found in many industrial, professional and consumer products and are of low toxicity, but do contain very low levels of residual monomers and process chemicals that can leach out during handling and use. Methyl Methacrylate, the principle monomer is of low toxicity, ...
Zhang Hanwang - - 2014
Nonnegative Matrix Factorization (NMF) has received considerable attention in image processing, computer vision and patter recognition. An important variant of NMF is Nonnegative Graph Embedding (NGE), which encodes the statistical or geometric information of data in the process of matrix factorization. NGE offers a general framework for unsupervised/supervised settings. However, ...
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