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Chang Fi-John FJ Department of Bioenvironmental Systems Engineering, National Taiwan University, Taipei 10617, Taiwan, ROC. Electronic address: - - 2014
We propose a systematical approach to assessing arsenic concentration in a river through: important factor extraction by a nonlinear factor analysis; arsenic concentration estimation by the neuro-fuzzy network; and impact assessment of important factors on arsenic concentration by the membership degrees of the constructed neuro-fuzzy network. The arsenic-contaminated Huang Gang ...
Gondro Cedric C The Centre for Genetic Analyses and Applications, University of New England, Armidale, NSW, - - 2014
In genome-wide association studies, quality control (QC) of genotypes is important to avoid spurious results. It is also important to maintain long-term data integrity, particularly in settings with ongoing genotyping (e.g. estimation of genomic breeding values). Here we discuss snpqc, a fully automated pipeline to perform QC analyses of Illumina ...
Mahoney Joseph M JM Engineering Science and Mechanics, The Pennsylvania State University, University Park, PA 16802, USA. Electronic address: - - 2014
Past efforts have been made to design single-user workstations to accommodate users' anthropometric and preference distributions. However, there is a lack of methods for designing workstations for group interaction. This paper introduces a method for sizing workstations to allow for a personal work area for each user and a shared ...
Chan Kitty S KS All of the authors are with the Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Baltimore, - - 2014
Objectives. We compared the strength of association between average 5-year county-level mortality rates and area-level measures, including air quality, sociodemographic characteristics, violence, and economic distress. Methods. We obtained mortality data from the National Vital Statistics System and linked it to socioeconomic and demographic data from the Census Bureau, air quality ...
Antón Assumpció - - 2014
This paper presents the inclusion of new, relevant impact categories for agriculture life cycle assessments. We performed a specific case study with a focus on the applicability of spatially explicit characterization factors. The main goals were to provide a detailed evaluation of these new impact category methods, compare the results ...
Yang Lan-Yan LY a Biostatistics and Informatics Unit, Clinical Trial Center, Chang Gung Memorial Hospital , Taoyuan , - - 2014
Abstract In recent years, quantitative evaluation for biosimilarity has been taken seriously due to the development of biosimilar products. The concept for assessment of biological products is very different form that of small molecule drug products since the variability in respect to the manufacturing process and environmental factors of the ...
Lee Roland A RA Industrial Research Chair on Cellulosic Ethanol, Department of Chemical and Biotechnological Engineering, Université de Sherbrooke, Sherbrooke, Québec J1K 2R1, - - 2014
Steam processes have often been associated with a severity factor, correlating the cooking temperature, time and catalyst used in the process. Although equations for treatments with and without acid catalyst have been suggested, there is so far no simple equation allowing a precise estimation of the amount of lignin extracted ...
Wong William W L - - 2014
Abstract As genomic sequencing technologies continue to advance, researchers are furthering their understanding of the relationships between genetic variants and expressed traits. However, missing data can significantly limit the power of a genetic study. Here, the use of a regularized generalized linear model, denoted by GLMNET, is proposed to impute ...
Ferraro Maria Brigida MB 1 Department of Statistical Sciences, Sapienza University of Rome , Rome, Italy - - 2014
Abstract Next-generation sequencing (NGS) is a new approach for biomedical research, useful for the diagnosis of genetic diseases in extremely heterogeneous conditions. In this work, we describe how data generated by high-throughput NGS experiments can be analyzed to find single nucleotide polymorphisms (SNPs) in DNA samples of patients affected by ...
Hoffman Gabriel E GE Icahn Institute for Genomics and Multiscale Biology, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, New York, USA and Department of Genetic Medicine, Weill Cornell Medical College, New York, New York, USA - - 2014
The linear mixed model is the state-of-the-art method to account for the confounding effects of kinship and population structure in genome-wide association studies (GWAS). Current implementations test the effect of one or more genetic markers while including prespecified covariates such as sex. Here we develop an efficient implementation of the ...
Xie Yiran Y Department of Psychiatry, Washington University in St. Louis, St. Louis, Mo., - - 2014
Genotype imputation is a powerful approach in genome-wide association studies (GWAS) because it can provide higher resolution for associated regions and facilitate meta-analysis. However, bias can exist if different genotyping arrays are used and are unbalanced for case versus control subjects. The intersection imputation strategy [imputation based on single nucleotide ...
Wojdacz Tomasz K TK Unit of Metals and Health, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, SE - 171 77, Sweden. - - 2014
The 450k Chip Analysis Methylation Pipeline (ChAMP) is a novel Illumina Infinium HumanMethylation450 BeadChip data processing algorithm that allows the analysis of copy number alterations (CNAs). With this pipeline we evaluated the prevalence of CNAs in peripheral blood leukocyte samples from healthy Argentinean Andean women with varying exposure to inorganic ...
Tran Duong T DT School of Dentistry, The University of Texas Health Science Center at Houston, Houston, TX, - - 2014
To evaluate bias associated with nine identified partial-mouth periodontal examination (PMPE) protocols in estimating periodontitis prevalence using the periodontitis case definition given by the Centers of Disease Control and Prevention and American Academy of Periodontology (CDC/AAP). Prevalence from full-mouth examination was determined in a sample of 3667 adults ≥30 years old ...
Gilbert Kimberly J KJ Department of Zoology, University of British Columbia, 6270 University Blvd., Vancouver, BC, V6T 1Z4, - - 2014
QST , a measure of quantitative genetic differentiation among populations, is an index that can suggest local adaptation if QST for a trait is sufficiently larger than the mean FST of neutral genetic markers. A previous method by Whitlock and Guillaume derived a simulation resampling approach to statistically test for ...
MacNamara Shev S Massachusetts Institute of Technology, Cambridge, MA 02139. Electronic address: - - 2014
The role of mathematical models of signaling networks is showcased by examples from Drosophila development. Three models of consecutive stages in dorsoventral patterning are presented. We begin with a compartmental model of intracellular reactions that generates a gradient of nuclear-localized Dorsal, exhibiting constant shape and dynamic amplitude. A simple thermodynamic ...
Tillmar Andreas O AO Department of Forensic Genetics and Forensic Toxicology, National Board of Forensic Medicine, Linköping, Sweden; Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden. Electronic address: - - 2014
The vast majority of human familial identifications based on DNA end up with a well founded conclusion, normally using a standard set of genetic short tandem repeat (STR) loci. There are, however, a proportion of cases that show ambiguous results. For such occasions a number of different supplementary markers could ...
Shevlin Mark M University of Ulster at Magee, L'Derry, Northern Ireland - - 2014
This study assessed the dimensional structure of the UCLA Loneliness Scale ([UCLA-LS], UCLA-3). Data from the Northern Ireland Young Life and Times Survey (2011), a survey of 1,434 16-year-olds, was used to examine the underlying factor structure of the scale. Confirmatory factor analysis was employed to compare alternative factor analytical ...
Xu Chang - - 2014
The purpose of the present study was to examine factors that influence strategic flexibility in computational estimation for Chinese- and Canadian-educated adults. Strategic flexibility was operationalized as the percentage of trials on which participants chose the problem-based procedure that best balanced proximity to the correct answer with simplification of the ...
Panda Suchita - - 2014
Over the last decade our understanding of human gut microbiology underwent a tremendous transformation. The limitations of culture-based methods have given way to Next Generation Sequencing techniques, allowing us to understand the microbial gut community in greater depth. The human GI-tract harbours one of the most complex and abundant ecosystems ...
Song Minsun M Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20850, - - 2014
Risk-prediction models need careful calibration to ensure they produce unbiased estimates of risk for subjects in the underlying population given their risk-factor profiles. As subjects with extreme high or low risk may be the most affected by knowledge of their risk estimates, checking the adequacy of risk models at the ...
Al-Hebshi N N NN Department of Preventive Dentistry-Periodontology, Faculty of Dentistry, Jazan University, Jazan, Saudi - - 2014
A number of species/phylotypes have been newly implicated as putative periopathogens. The objective of this study was to explore associations among classical and new pathogens in subgingival biofilm and to assess their relative importance to chronic periodontitis. Pooled subgingival biofilm samples were obtained from 40 patients with chronic periodontitis and ...
Sayah Fatima Al FA Department of Public Health Sciences, University of Alberta, Edmonton, - - 2014
To examine the measurement properties of the 16 screening questions (16-SQ) of inadequate health literacy (HL) and their briefer version (3-SQ), and identify the best screen for inadequate HL in non-white populations. Sample included 378 individuals with type-2 diabetes. We computed sensitivity, specificity, positive and negative likelihood ratios, and C-indices, ...
Rimmer Andy A 1] Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. - - 2014
High-throughput DNA sequencing technology has transformed genetic research and is starting to make an impact on clinical practice. However, analyzing high-throughput sequencing data remains challenging, particularly in clinical settings where accuracy and turnaround times are critical. We present a new approach to this problem, implemented in a software package called ...
Chen Wenan W Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of - - 2014
Recently, Wen and Stephens (Wen and Stephens [2010] Ann Appl Stat 4(3):1158-1182) proposed a linear predictor, called BLIMP, that uses conditional multivariate normal moments to impute genotypes with accuracy similar to current state-of-the-art methods. One novelty is that it regularized the estimated covariance matrix based on a model from population ...
Acar Evrim - - 2014
Analysis of data from multiple sources has the potential to enhance knowledge discovery by capturing underlying structures, which are, otherwise, difficult to extract. Fusing data from multiple sources has already proved useful in many applications in social network analysis, signal processing and bioinformatics. However, data fusion is challenging since data ...
Gonçalves Caroline M - - 2014
In Brazil, dengue epidemics erupt sporadically throughout the country and it is unclear if outbreaks may initiate a sustainable transmission cycle. There are few studies evaluating the ability of Brazilian Aedes aegypti populations to transmit dengue virus (DENV). The aim of this study was to compare DENV susceptibility of field-captured ...
Ramayah T T School of Management, Universiti Sains Malaysia, Penang, - - 2014
There is a belief that academics tend to hold on tightly to their knowledge and intellectual resources. However, not much effort has been put into the creation of a valid and reliable instrument to measure knowledge sharing behavior among the academics. To apply and validate the Knowledge Sharing Behavior Scale ...
Leblois Raphaël R INRA, UMR 1062 CBGP (INRA-IRD-CIRAD-Montpellier Supagro), Montpellier, FranceMuséum National d'Histoire Naturelle, CNRS, UMR OSEB, Paris, FranceInstitut de Biologie Computationnelle, Montpellier, France - - 2014
Understanding the demographic history of populations and species is a central issue in evolutionary biology and molecular ecology. In the present work, we develop a maximum likelihood method for the inference of past changes in population size from microsatellite allelic data. Our method is based on importance sampling of gene ...
Alver Y Y Department of Civil Engineering, Ege University, Izmir, Turkey. Electronic address: - - 2014
Young drivers' high traffic violation involvement rate and significant contribution to traffic crashes compared to older drivers creates the need for detailed analyses of factors affecting young drivers' behaviors. This study is based on survey data collected from 2,057 18-29 year old young adults. Data were collected via face-to-face questionnaire ...
Liu Z Z Vereinigte Informationssysteme Tierhaltung w.V. (VIT), Heideweg 1, D-27283 Verden, Germany. Electronic address: - - 2014
Compared with the currently widely used multi-step genomic models for genomic evaluation, single-step genomic models can provide more accurate genomic evaluation by jointly analyzing phenotypes and genotypes of all animals and can properly correct for the effect of genomic preselection on genetic evaluations. The objectives of this study were to ...
Hermann Robert R Montanuniversitaet Leoben, Leoben, Austria - - 2014
For the first time, basic technical and economic studies for landfill mining are being carried out in Austria on the basis of a pilot project. An important goal of these studies is the collection of elementary data as the basis for an integrated ecological and economic assessment of landfill mining ...
Khansefid M M Department of Environment and Primary Industries, AgriBio, 5 Ring Road, Bundoora, VIC 3083, Australia Dairy Futures Cooperative Research Centre (CRC), AgriBio, 5 Ring Road, Bundoora, VIC 3083, Australia Department of Agriculture and Food Systems, Melbourne School of Land and Environment, The University of Melbourne, Parkville, VIC 3010, Australia - - 2014
Residual feed intake (RFI) is a measure of the efficiency of animals in feed utilization. The accuracies of genomic EBVs (GEBVs) for RFI could be improved by increasing the size of the reference population. Combining RFI records of different breeds is a way to do that. The aims of this ...
Kling Daniel D Department of Family Genetics, Norwegian Institute of Public Health, Oslo, Norway; Department for Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, Aas, Norway. Electronic address: - - 2014
In relationship testing the aim is to determine the most probable pedigree structure given genetic marker data for a set of persons. Disaster Victim Identification (DVI) based on DNA data from presumed relatives of the missing persons can be considered to be a collection of relationship problems. Forensic calculations in ...
Szpiech Zachary A ZA Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, USA - - 2014
Haplotype-based scans to detect natural selection are useful to identify recent or ongoing positive selection in genomes. As both real and simulated genomic datasets grow larger, spanning thousands of samples and millions of markers, there is a need for a fast and efficient implementation of these scans for general use. ...
Duangjit Sureewan S Faculty of Pharmacy, Silpakorn - - 2014
A nonlinear response surface method incorporating multivariate spline interpolation (RSM-S) is a useful technique for the optimization of pharmaceutical formulations, although the direct reliability of the optimal formulation must be evaluated. In this study, we demonstrated the feasibility of using the bootstrap (BS) resampling technique to evaluate the direct reliability ...
Rañola John Michael JM Department of Statistics, University of Washington - - 2014
Unique modeling and computational challenges arise in locating the geographic origin of individuals based on their genetic backgrounds. SNPs vary widely in informativeness, allele frequencies change nonlinearly with geography, and reliable localization requires evidence to be integrated across a multitude of SNPs. These problems become even more acute for individuals ...
Maciejewski Wes W The University of British Columbia, Mathematics, 1984 Mathematics Road, Vancouver, British Columbia, Canada V6T - - 2014
Understanding the influence of an environment on the evolution of its resident population is a major challenge in evolutionary biology. Great progress has been made in homogeneous population structures while heterogeneous structures have received relatively less attention. Here we present a structured population model where different individuals are best suited ...
Chen Shyi-Ming - - 2014
In this paper, we present a new method for fuzzy forecasting based on two-factors second-order fuzzy-trend logical relationship groups and the probabilities of trends of fuzzy-trend logical relationships. Firstly, the proposed method fuzzifies the historical training data of the main factor and the secondary factor into fuzzy sets, respectively, to ...
Chaturvedi Nimisha - - 2014
A number of statistical models has been proposed for studying the association between geneexpression and copy number data in integrated analysis. The next step is to compare associationpatterns between different groups of samples. We propose a method, named dSIM, to find differences in association between copy number and geneexpression, when ...
Pissis Solon P - - 2014
Identifying repeated factors that occur in a string of letters or common factors that occur in a setof strings represents an important task in computer science and biology. Such patterns are calledmotifs, and the process of identifying them is called motif extraction. In biology, motif extractionconstitutes a fundamental step in ...
Vilseck Jonah Z JZ Department of Chemistry, Yale University , New Haven, Connecticut 06520-8107, United - - 2014
The recently developed Charge Model 5 (CM5) is tested for its utility in condensed-phase simulations. The CM5 approach, which derives partial atomic charges from Hirshfeld population analyses, provides excellent results for gas-phase dipole moments and is applicable to all elements of the periodic table. Herein, the adequacy of scaled CM5 ...
McCullough Erin L EL Division of Biological Sciences, University of Montana, Missoula, MT, USA - - 2014
The horns of giant rhinoceros beetles are a classic example of the elaborate morphologies that can result from sexual selection. Theory predicts that sexual traits will evolve to be increasingly exaggerated until survival costs balance the reproductive benefits of further trait elaboration. In Trypoxylus dichotomus, long horns confer a competitive ...
Leontyev Igor V IV Department of Chemistry, University of California Davis, One Shields Avenue, Davis, California 95616, - - 2014
Earlier, using phenomenological approach, we showed that in some cases polarizable models of condensed phase systems can be reduced to nonpolarizable equivalent models with scaled charges. Examples of such systems include ionic liquids, TIPnP-type models of water, protein force fields, and others, where interactions and dynamics of inherently polarizable species ...
Olatunji Bunmi O BO Vanderbilt University, Nashville, TN, USA - - 2014
The current research evaluated a bifactor model for the Disgust Emotion Scale (DES) in three samples: N = 1,318 nonclinical participants, N = 152 clinic-referred patients, and N = 352 nonclinical participants. The primary goals were to (a) use bifactor modeling to examine the latent structure of the DES and ...
Gerrard Paul P Spaulding Rehabilitation Hospital and Harvard Medical School, Boston, - - 2014
To investigate the neurobehavioral pattern of recovery of consciousness as reflected by performance on the subscales of the Coma Recovery Scale - Revised (CRS-R). Retrospective item response theory and factor analysis. Inpatient rehabilitation facilities in the United States and Europe. Rehabilitation inpatients (N=180) with post-traumatic disturbance in consciousness who participated ...
Bandyopadhyay Uttam U Department of Statistics, University of Calcutta, Kolkata, West Bengal, 700035, - - 2014
Matched case-control paired data are commonly used to study the association between a disease and an exposure of interest. This work provides a consistent test for this association with respect to the conditional odds ratio (ORc), which is a measure of association that is also valid in prospective studies. We ...
Cabras Stefano S Department of Statistics, Universidad Carlos III de Madrid, Getafe, Spain; Department of Mathematics and Informatics, Università di Cagliari, Cagliari, - - 2014
This paper considers the problem of selecting a set of regressors when the response variable is distributed according to a specified parametric model and observations are censored. Under a Bayesian perspective, the most widely used tools are Bayes factors (BFs), which are undefined when improper priors are used. In order ...
Dixon Josie J Personal Social Services Research Unit, London School of Economics, London, - - 2014
This paper examines the numbers of people with dementia who could be diagnosed and the likely cost-effectiveness of a one-off screen for dementia for people aged 75 years in England and Wales. The study uses static decision modelling to compare a one-off screen for dementia with a no-screen scenario. Estimates for ...
Sesé-Abad Albert A Balearic Islands University, Palma, - - 2014
Evidence-based practice may be implemented more successfully if the barriers to its implementation have been previously identified. Many of the available instruments to measure these barriers have been validated in single samples or without confirmatory analyses. The objective of the study was to contrast the goodness of fit of two ...
Wang Kai K Department of Industrial and Management System Engineering, West Virginia University , Morgantown, West Virginia 26506, United - - 2014
One of the most fundamental steps in risk assessment is to quantify the exposure-response relationship for the material/chemical of interest. This work develops a new statistical method, referred to as SKQ (stochastic kriging with qualitative factors), to synergistically model exposure-response data, which often arise from multiple sources (e.g., laboratories, animal ...
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