Search Results
Results 151 - 200 of 6396
1 2 3 4 5 6 7 8 9 10 >
Eaves Lindon J LJ Department of Human and Molecular Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA, USA, - - 2014
Genome wide complex trait analysis (GCTA) is extended to include environmental effects of the maternal genotype on offspring phenotype ("maternal effects", M-GCTA). The model includes parameters for the direct effects of the offspring genotype, maternal effects and the covariance between direct and maternal effects. Analysis of simulated data, conducted in ...
Wang Liya L Institute of Disease Control and Prevention, Academy of Military Medical Science, Beijing, People's Republic of - - 2014
Japanese encephalitis (JE) is the most common cause of viral encephalitis and an important public health concern in the Asia-Pacific region, particularly in China where 50% of global cases are notified. To explore the association between environmental factors and human JE cases and identify the high risk areas for JE ...
Middelweerd Anouk - - 2014
BackgroundIn May 2013, the iTunes and Google Play stores contained 23,490 and 17,756 smartphone applications (apps) categorized as Health and Fitness, respectively. The quality of these apps, in terms of applying established health behavior change techniques, remains unclear.MethodsThe study sample was identified through systematic searches in iTunes and Google Play. ...
Baar Johanna J a Faculty of Architecture and Social Sciences , Leipzig University of Applied Sciences , Leipzig , - - 2014
Residential self-selection is supposed to bias the relation between residential environments and physical activity, but empirical analyses are still rare. This study examines the association while simultaneously considering the effect of residential self-selection criteria. One thousand two hundred and forty-five German students were asked to report their physical activity, their ...
Wang Jinjun J Division of Rheumatology, Allergy and Clinical Immunology, University of California, Davis, - - 2014
Within the last decade, several mouse models that manifest characteristic features of primary biliary cirrhosis (PBC) with antimitochondrial antibodies (AMAs) and immune-mediated biliary duct pathology have been reported. Here, the authors discuss the current findings on two spontaneous (nonobese diabetic autoimmune biliary disease [NOD.ABD] and dominant negative transforming growth factor-β ...
Haller J J Institute of Experimental Medicine, Budapest, - - 2014
We review here the impact of early adversities on the development of violence and antisocial behaviour in humans, and present three etiological animal models of escalated rodent aggression, each disentangling the consequences of one particular adverse early-life factor. The review of the human data and those obtained with the animal ...
Gajewska M M Systems Toxicology Unit and EURL ECVAM, Institute for Health and Consumer Protection, European Commission, Joint Research Centre, 21027 Ispra, VA, Italy; University of Milano Biccoca, Dep. of Earth and Environmental Sciences, Piazza della Scienza 1, Milano, Italy; Helmholtz Zentrum München - German Research Center for Environmental Health (GmbH), Molecular EXposomics (MEX), Ingolstädter Landstr.1, D-85764 Neuherberg, Germany. Electronic address: - - 2014
Joint physiologically-based toxicokinetic and toxicodynamic (PBTK/TD) mqodelling was applied to simulate concentration-time profiles of nicotine, a well-known stimulant, in the human body following single and repeated dosing. Both kinetic and dynamic models were first calibrated by using in vivo literature data for the Caucasian population. The models were then used ...
Lahey Benjamin B BB University of Chicago, Chicago, IL, - - 2014
The best-fitting model of the structure of common psychopathology often includes a general factor on which all dimensions of psychopathology load. Such a general factor would be important if it reflects etiologies and mechanisms shared by all dimensions of psychopathology. Nonetheless, a viable alternative explanation is that the general factor ...
Brennan Katharine A KA School of Psychology, Victoria University of Wellington, PO Box 600, Wellington 6140, New Zealand. Electronic address: - - 2014
Smoking tobacco is highly addictive and a leading preventable cause of death. The main addictive constituent is nicotine; consequently it has been administered to laboratory animals to model tobacco dependence. Despite extensive use, this model might not best reflect the powerful nature of tobacco dependence because nicotine is a weak ...
Lu Angela H AH Division of Nutritional Sciences, Cornell University, Ithaca, NY. Electronic address: - - 2014
To develop and apply a framework exploring the extent of involvement in promoting environmental changes to prevent obesity by a group of nutrition educators (NE). Cross-sectional, mixed methods: qualitative interviews informed framework development; survey applied framework to describe NE's involvement in environmental changes. Cooperative Extension in New York State.Participants: Interviewees ...
Taroni F F University of Lausanne, School of Criminal Justice, Lausanne, Switzerland. Electronic address: - - 2014
This paper extends previous research [1] on the use of multivariate continuous data in comparative handwriting examinations, notably for gender classification. A database has been constructed by analyzing the contour shape of loop characters of type a and d by means of Fourier analysis, which allows characters to be described ...
Oliver Jeffrey C JC Department of Ecology and Evolutionary Biology, Yale University, New Haven, CT 06520, USA Department of Integrative Biology, Oregon State University, Corvallis, OR 97331, USA - - 2014
Serial homologues are repeated traits that share similar development but occur in different parts of the body. Variation in number of repeats accounts for substantial diversity in animal form and considerable work has focused on identifying the factors accounting for this variation. Little is known, however, about how serial homologues ...
Thrasher James F JF University of South Carolina, Columbia, South Carolina, USA National Institute of Public Health, Cuernavaca, - - 2014
Health warning labels (HWLs) on tobacco packaging can be used to provide smoking cessation information, but the impact of this information is not well understood. Online consumer panels of adult smokers from Canada, Australia and Mexico were surveyed in September 2012, January 2013 and May 2013; replenishment was used to ...
Wang Xuefeng - - 2014
Machine learning, particularly kernel methods, has been demonstrated as a promising new tool to tackle the challenges imposed by today's explosive data growth in genomics. They provide a practical and principled approach to learning how a large number of genetic variants are associated with complex phenotypes, to help reveal the ...
Zouré Honorat Gm - - 2014
The original aim of the African Programme for Onchocerciasis Control (APOC) was to control onchocerciasis as a public health problem in 20 African countries. In order to identify all high risk areas where ivermectin treatment was needed to achieve control, APOC used Rapid Epidemiological Mapping of Onchocerciasis (REMO). REMO involved ...
Biscarini Filippo - - 2014
Genomic information can be used to predict not only continuous but also categorical (e.g. binomial)traits. Several traits of interest in human medicine and agriculture present a discrete distribution ofphenotypes (e.g. disease status). Root vigor in sugar beet (B. vulgaris) is an example of binomialtrait of agronomic importance. In this paper, ...
Schlage Walter K WK Philip Morris International R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, 2000 Neuchâtel, - - 2014
Abstract Smoking has been associated with diseases of the lung, pulmonary airways, and oral cavity. Cytologic, genomic, and transcriptomic changes in oral mucosa correlate with oral preneoplasia, cancer, and inflammation (e.g. periodontitis). Alteration of smoking-related gene expression changes in oral epithelial cells is similar to that in bronchial and nasal ...
Gu Xin - - 2014
Bayesian evaluation of inequality constrained hypotheses enables researchers to investigate their expectations with respect to the structure among model parameters. This article proposes an approximate Bayes procedure that can be used for the selection of the best of a set of inequality constrained hypotheses based on the Bayes factor in ...
Weyand Angela C AC Division of Pediatric Hematology and Oncology, Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, Michigan, - - 2014
Although the zebrafish has been established as a research tool over the past two to three decades, in hematology it has primarily been used to investigate areas distinct from coagulation. The advantages of this vertebrate model include high fecundity, rapid and external development, and conservation of virtually all clotting factors ...
Bellot Sidonie S Systematic Botany and Mycology, University of Munich (LMU), Menzinger Str. 67, 80638 Munich, Germany. Electronic address: - - 2014
Gene trees of holoparasitic plants usually show distinctly longer branch lengths than seen in photosynthetic closest relatives. Such substitution rate jumps have made it difficult to infer the absolute divergence times of parasites. An additional problem is that parasite clades often lack a fossil record. Using nuclear and mitochondrial DNA ...
Chivers W J WJ Faculty of Science and IT, University of Newcastle, Ourimbah, NSW, Australia. Electronic address: - - 2014
Models of near-exclusive predator-prey systems such as that of the Canadian lynx and snowshoe hare have included factors such as a second prey species, a Holling Type II predator response and climatic or seasonal effects to reproduce sub-sets of six signature patterns in the empirical data. We present an agent-based ...
Neuparth Teresa T CIMAR/CIIMAR-Interdisciplinary Centre of Marine and Environmental Research, University of Porto, Rua dos Bragas 177, 4050-123 Porto, Portugal. Electronic address: - - 2014
Simvastatin (SIM), a hypocholesterolaemic drug, is among the most widely used pharmaceuticals worldwide and is therefore of emerging environmental concern. Despite the ubiquitous nature of SIM in the aquatic ecosystems, significant uncertainties exist about sublethal effects of the drug in aquatic organisms. Therefore, here we aimed at investigating a multi-level ...
Yildirim Suleyman S The Institute for Genomic Biology, University of Illinois, Urbana, IL, - - 2014
Bacterial communities colonizing the reproductive tracts of primates (including humans) impact the health, survival and fitness of the host, and thereby the evolution of the host species. Despite their importance, we currently have a poor understanding of primate microbiomes. The composition and structure of microbial communities vary considerably depending on ...
Grove J Morgan JM USDA Forest Service Northern Research Station, Baltimore Field Station, UMBC, 5522 Research Park Drive, Baltimore, MD, 21228, USA, - - 2014
Several social theories have been proposed to explain the uneven distribution of vegetation in urban residential areas: population density, social stratification, luxury effect, and ecology of prestige. We evaluate these theories using a combination of demographic and socio-economic predictors of vegetative cover on all residential lands in New York City. ...
Liu Hong H China Economics and Management Academy, Central University of Finance and Economics, Beijing, - - 2014
This paper examines how Chinese smokers respond to tax-driven cigarette price increases by estimating a discrete choice model of demand for differentiated products, using annual nationwide brand-level cigarette sales data in China from 2005 to 2010. We allow for substitution between different cigarette brands and also incorporate key features of ...
Chang Fi-John FJ Department of Bioenvironmental Systems Engineering, National Taiwan University, Taipei 10617, Taiwan, ROC. Electronic address: - - 2014
We propose a systematical approach to assessing arsenic concentration in a river through: important factor extraction by a nonlinear factor analysis; arsenic concentration estimation by the neuro-fuzzy network; and impact assessment of important factors on arsenic concentration by the membership degrees of the constructed neuro-fuzzy network. The arsenic-contaminated Huang Gang ...
Gondro Cedric C The Centre for Genetic Analyses and Applications, University of New England, Armidale, NSW, - - 2014
In genome-wide association studies, quality control (QC) of genotypes is important to avoid spurious results. It is also important to maintain long-term data integrity, particularly in settings with ongoing genotyping (e.g. estimation of genomic breeding values). Here we discuss snpqc, a fully automated pipeline to perform QC analyses of Illumina ...
Mahoney Joseph M JM Engineering Science and Mechanics, The Pennsylvania State University, University Park, PA 16802, USA. Electronic address: - - 2014
Past efforts have been made to design single-user workstations to accommodate users' anthropometric and preference distributions. However, there is a lack of methods for designing workstations for group interaction. This paper introduces a method for sizing workstations to allow for a personal work area for each user and a shared ...
Chan Kitty S KS All of the authors are with the Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Baltimore, - - 2014
Objectives. We compared the strength of association between average 5-year county-level mortality rates and area-level measures, including air quality, sociodemographic characteristics, violence, and economic distress. Methods. We obtained mortality data from the National Vital Statistics System and linked it to socioeconomic and demographic data from the Census Bureau, air quality ...
Antón Assumpció - - 2014
This paper presents the inclusion of new, relevant impact categories for agriculture life cycle assessments. We performed a specific case study with a focus on the applicability of spatially explicit characterization factors. The main goals were to provide a detailed evaluation of these new impact category methods, compare the results ...
Yang Lan-Yan LY a Biostatistics and Informatics Unit, Clinical Trial Center, Chang Gung Memorial Hospital , Taoyuan , - - 2014
Abstract In recent years, quantitative evaluation for biosimilarity has been taken seriously due to the development of biosimilar products. The concept for assessment of biological products is very different form that of small molecule drug products since the variability in respect to the manufacturing process and environmental factors of the ...
Lee Roland A RA Industrial Research Chair on Cellulosic Ethanol, Department of Chemical and Biotechnological Engineering, Université de Sherbrooke, Sherbrooke, Québec J1K 2R1, - - 2014
Steam processes have often been associated with a severity factor, correlating the cooking temperature, time and catalyst used in the process. Although equations for treatments with and without acid catalyst have been suggested, there is so far no simple equation allowing a precise estimation of the amount of lignin extracted ...
Wong William W L - - 2014
Abstract As genomic sequencing technologies continue to advance, researchers are furthering their understanding of the relationships between genetic variants and expressed traits. However, missing data can significantly limit the power of a genetic study. Here, the use of a regularized generalized linear model, denoted by GLMNET, is proposed to impute ...
Ferraro Maria Brigida MB 1 Department of Statistical Sciences, Sapienza University of Rome , Rome, Italy - - 2014
Abstract Next-generation sequencing (NGS) is a new approach for biomedical research, useful for the diagnosis of genetic diseases in extremely heterogeneous conditions. In this work, we describe how data generated by high-throughput NGS experiments can be analyzed to find single nucleotide polymorphisms (SNPs) in DNA samples of patients affected by ...
Hoffman Gabriel E GE Icahn Institute for Genomics and Multiscale Biology, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, New York, USA and Department of Genetic Medicine, Weill Cornell Medical College, New York, New York, USA - - 2014
The linear mixed model is the state-of-the-art method to account for the confounding effects of kinship and population structure in genome-wide association studies (GWAS). Current implementations test the effect of one or more genetic markers while including prespecified covariates such as sex. Here we develop an efficient implementation of the ...
Xie Yiran Y Department of Psychiatry, Washington University in St. Louis, St. Louis, Mo., - - 2014
Genotype imputation is a powerful approach in genome-wide association studies (GWAS) because it can provide higher resolution for associated regions and facilitate meta-analysis. However, bias can exist if different genotyping arrays are used and are unbalanced for case versus control subjects. The intersection imputation strategy [imputation based on single nucleotide ...
Wojdacz Tomasz K TK Unit of Metals and Health, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, SE - 171 77, Sweden. - - 2014
The 450k Chip Analysis Methylation Pipeline (ChAMP) is a novel Illumina Infinium HumanMethylation450 BeadChip data processing algorithm that allows the analysis of copy number alterations (CNAs). With this pipeline we evaluated the prevalence of CNAs in peripheral blood leukocyte samples from healthy Argentinean Andean women with varying exposure to inorganic ...
Tran Duong T DT School of Dentistry, The University of Texas Health Science Center at Houston, Houston, TX, - - 2014
To evaluate bias associated with nine identified partial-mouth periodontal examination (PMPE) protocols in estimating periodontitis prevalence using the periodontitis case definition given by the Centers of Disease Control and Prevention and American Academy of Periodontology (CDC/AAP). Prevalence from full-mouth examination was determined in a sample of 3667 adults ≥30 years old ...
Gilbert Kimberly J KJ Department of Zoology, University of British Columbia, 6270 University Blvd., Vancouver, BC, V6T 1Z4, - - 2014
QST , a measure of quantitative genetic differentiation among populations, is an index that can suggest local adaptation if QST for a trait is sufficiently larger than the mean FST of neutral genetic markers. A previous method by Whitlock and Guillaume derived a simulation resampling approach to statistically test for ...
MacNamara Shev S Massachusetts Institute of Technology, Cambridge, MA 02139. Electronic address: - - 2014
The role of mathematical models of signaling networks is showcased by examples from Drosophila development. Three models of consecutive stages in dorsoventral patterning are presented. We begin with a compartmental model of intracellular reactions that generates a gradient of nuclear-localized Dorsal, exhibiting constant shape and dynamic amplitude. A simple thermodynamic ...
Tillmar Andreas O AO Department of Forensic Genetics and Forensic Toxicology, National Board of Forensic Medicine, Linköping, Sweden; Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden. Electronic address: - - 2014
The vast majority of human familial identifications based on DNA end up with a well founded conclusion, normally using a standard set of genetic short tandem repeat (STR) loci. There are, however, a proportion of cases that show ambiguous results. For such occasions a number of different supplementary markers could ...
Shevlin Mark M University of Ulster at Magee, L'Derry, Northern Ireland - - 2014
This study assessed the dimensional structure of the UCLA Loneliness Scale ([UCLA-LS], UCLA-3). Data from the Northern Ireland Young Life and Times Survey (2011), a survey of 1,434 16-year-olds, was used to examine the underlying factor structure of the scale. Confirmatory factor analysis was employed to compare alternative factor analytical ...
Xu Chang - - 2014
The purpose of the present study was to examine factors that influence strategic flexibility in computational estimation for Chinese- and Canadian-educated adults. Strategic flexibility was operationalized as the percentage of trials on which participants chose the problem-based procedure that best balanced proximity to the correct answer with simplification of the ...
Panda Suchita - - 2014
Over the last decade our understanding of human gut microbiology underwent a tremendous transformation. The limitations of culture-based methods have given way to Next Generation Sequencing techniques, allowing us to understand the microbial gut community in greater depth. The human GI-tract harbours one of the most complex and abundant ecosystems ...
Song Minsun M Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20850, - - 2014
Risk-prediction models need careful calibration to ensure they produce unbiased estimates of risk for subjects in the underlying population given their risk-factor profiles. As subjects with extreme high or low risk may be the most affected by knowledge of their risk estimates, checking the adequacy of risk models at the ...
Al-Hebshi N N NN Department of Preventive Dentistry-Periodontology, Faculty of Dentistry, Jazan University, Jazan, Saudi - - 2014
A number of species/phylotypes have been newly implicated as putative periopathogens. The objective of this study was to explore associations among classical and new pathogens in subgingival biofilm and to assess their relative importance to chronic periodontitis. Pooled subgingival biofilm samples were obtained from 40 patients with chronic periodontitis and ...
Sayah Fatima Al FA Department of Public Health Sciences, University of Alberta, Edmonton, - - 2014
To examine the measurement properties of the 16 screening questions (16-SQ) of inadequate health literacy (HL) and their briefer version (3-SQ), and identify the best screen for inadequate HL in non-white populations. Sample included 378 individuals with type-2 diabetes. We computed sensitivity, specificity, positive and negative likelihood ratios, and C-indices, ...
Rimmer Andy A 1] Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. - - 2014
High-throughput DNA sequencing technology has transformed genetic research and is starting to make an impact on clinical practice. However, analyzing high-throughput sequencing data remains challenging, particularly in clinical settings where accuracy and turnaround times are critical. We present a new approach to this problem, implemented in a software package called ...
Chen Wenan W Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of - - 2014
Recently, Wen and Stephens (Wen and Stephens [2010] Ann Appl Stat 4(3):1158-1182) proposed a linear predictor, called BLIMP, that uses conditional multivariate normal moments to impute genotypes with accuracy similar to current state-of-the-art methods. One novelty is that it regularized the estimated covariance matrix based on a model from population ...
Acar Evrim - - 2014
Analysis of data from multiple sources has the potential to enhance knowledge discovery by capturing underlying structures, which are, otherwise, difficult to extract. Fusing data from multiple sources has already proved useful in many applications in social network analysis, signal processing and bioinformatics. However, data fusion is challenging since data ...
1 2 3 4 5 6 7 8 9 10 >