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Beck L L CEA, DEN, Service de Recherches de Métallurgie Physique, Laboratoire JANNUS, 91191 Gif-sur-Yvette, France; C2RMF - UMR171 CNRS, Centre de Recherche et de Restauration des Musées de France, Palais du Louvre, Porte des Lions, 14 quai François Mitterrand, 75001 Paris, France. Electronic address: - - 2014
Study of prehistoric art is playing a major role in the knowledge of human evolution. Many scientific methods are involved in this investigation including chemical analysis of pigments present on artefacts or applied to cave walls. In the past decades, the characterization of coloured materials was carried on by taking ...
Roshan A A MRC Cancer Cell Unit, Hutchison-MRC Research Centre, Cambridge CB2 2XZ, - - 2014
Biological tools such as genetic lineage tracing, three-dimensional confocal microscopy and next-generation DNA sequencing are providing new ways to quantify the distribution of clones of normal and mutated cells. Understanding population-wide clone size distributions in vivo is complicated by multiple cell types within observed tissues, and overlapping birth and death ...
Cervera Javier J Departament de Termodinàmica, Universitat de València, Burjassot 46100, Spain - - 2014
The interplay between cooperativity and diversity is crucial for biological ensembles because single molecule experiments show a significant degree of heterogeneity and also for artificial nanostructures because of the high individual variability characteristic of nanoscale units. We study the cross-effects between cooperativity and diversity in model threshold ensembles composed of ...
Read Mark M Department of Electronics, University of York, York YO10 5GW, UK - - 2014
We present a framework to assist the diagrammatic modelling of complex biological systems using the unified modelling language (UML). The framework comprises three levels of modelling, ranging in scope from the dynamics of individual model entities to system-level emergent properties. By way of an immunological case study of the mouse ...
Velazquez Miguel A MA a Centre for Biological Sciences , University of Southampton, Southampton General Hospital , Southampton , United - - 2014
Ovarian transvaginal ultrasonography (OTU) has been used world-wide for commercial ovum pick-up programs for in vitro embryo production in elite herds, providing an excellent model for the elucidation of factors controlling bovine oocyte developmental competence. Noninvasive sampling and treatment of ovarian structures is easily accomplished with bovine OTU techniques providing ...
Cirovic Ivana M IM Business Technical College of Vocational Studies, Uzice, - - 2014
Carl Bovill suggested and described a method of generating rhythm in architecture with the help of fractional Brownian functions, as they are mathematical models of natural rhythm. A relationship established in the stated procedure between fractional Brownian functions as models of rhythm, and the observed group of architectural elements, is ...
Li Meixia M State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, - - 2014
Long noncoding RNA (lncRNA) is an emerging category of transcript, and comprises the majority of the transcriptome of various complex organisms. The biological functions of only a handful of lncRNAs have been investigated in detail, showing involvement in a wide range of biological processes through different functional paradigms. However, most ...
Kheirabadi Khabat K Department of Animal Science, University of Tabriz, Tabriz, - - 2014
We compared the goodness of fit of three mathematical functions (including: Legendre polynomials, Lidauer-Mäntysaari function and Wilmink function) for describing the lactation curve of primiparous Iranian Holstein cows by using multiple-trait random regression models (MT-RRM). Lactational submodels provided the largest daily additive genetic (AG) and permanent environmental (PE) variance estimates ...
Stahl Ulrike U Functional Biogeography Research Group, Max Planck Institute for Biogeochemistry, 07701 Jena, Germany; - - 2014
Using functional traits to explain species' range limits is a promising approach in functional biogeography. It replaces the idiosyncrasy of species-specific climate ranges with a generic trait-based predictive framework. In addition, it has the potential to shed light on specific filter mechanisms creating large-scale vegetation patterns. However, its application to ...
Whittaker Robert J RJ School of Geography and the Environment, University of Oxford, Oxford OX1 3QY, United Kingdom; Centre for Macroecology, Evolution and Climate, Department of Biology, University of Copenhagen, Copenhagen, Denmark; - - 2014
Analyses of species-diversity patterns of remote islands have been crucial to the development of biogeographic theory, yet little is known about corresponding patterns in functional traits on islands and how, for example, they may be affected by the introduction of exotic species. We collated trait data for spiders and beetles ...
Violle Cyrille C Centre d'Ecologie Fonctionelle et Evolutive, Unité Mixte de Recherche 5175, Centre National de la Recherche Scientifique, Université de Montpellier, Université Paul-Valéry Montpellier, École Pratique des Hautes Études, F-34293 Montpellier Cedex 5, France; Centre de Synthèse et d'Analyse sur la Biodiversité/Fondation pour la Recherche sur la Biodiversité, Domaine du Petit Arbois, Avenue Louis Philibert, 13545 Aix-en-Provence, France; - - 2014
Understanding, modeling, and predicting the impact of global change on ecosystem functioning across biogeographical gradients can benefit from enhanced capacity to represent biota as a continuous distribution of traits. However, this is a challenge for the field of biogeography historically grounded on the species concept. Here we focus on the ...
Dauphas Nicolas N Origins Laboratory, Department of the Geophysical Sciences and Enrico Fermi Institute, University of Chicago, 5734 South Ellis Avenue, Chicago, IL 60637, USA - - 2014
Geochemical evidence suggests that the material accreted by the Earth did not change in nature during Earth's accretion, presumably because the inner protoplanetary disc had uniform isotopic composition similar to enstatite chondrites, aubrites and ungrouped achondrite NWA 5363/5400. Enstatite meteorites and the Earth were derived from the same nebular reservoir ...
Day James M D JM Scripps Isotope Geochemistry Laboratory, Geosciences Research Division, Scripps Institution of Oceanography, La Jolla, CA 92093-0244, USA - - 2014
The Moon is depleted in volatile elements relative to the Earth and Mars. Low abundances of volatile elements, fractionated stable isotope ratios of S, Cl, K and Zn, high μ ((238)U/(204)Pb) and long-term Rb/Sr depletion are distinguishing features of the Moon, relative to the Earth. These geochemical characteristics indicate both ...
Jochemsen-Van Der Leeuw H G A Ria HG University of Amsterdam , The - - 2014
Abstract Background: Continuing Professional Development (CPD) and Faculty Development (FD) courses have been designed in the expectation that a cascade effect will occur, consisting of a conveyance of information from the courses to clinical trainers to daily practice and/or to trainees by means of role modeling. Purpose: The aims of ...
Conrad Andrea A Department of Medical Informatics, Biometry and Epidemiology-IBE, Pettenkofer School of Public Health (PSPH LMU), Research Unit for Biopsychosocial Health, Ludwig-Maximilians University (LMU), Marchioninistr. 17, 81377, Munich, - - 2014
The Brief International Classification of Functioning, Disability and Health (ICF) Core Set for MS was developed to capture functioning in people with multiple sclerosis (pwMS). This study examined whether categories in the Brief ICF Core Set for MS best capture different levels of functioning in pwMS. We used data of ...
Gabel Joffrey - - 2014
Training machine learning algorithms with protein-ligand descriptors has recently gained considerable attention to predict binding constants from atomic coordinates. Starting from a series of recent reports stating the advantages of this approach over empirical scoring functions, we could indeed reproduced the claimed superiority of Random Forest and Support Vector Machine-based ...
Chen Guangchao G Key Laboratory of Industrial Ecology and Environmental Engineering (MOE), School of Environmental Science and Technology, Dalian University of Technology, Dalian, China; Institute of Environmental Sciences (CML), Leiden University, Leiden, The - - 2014
Biodegradation is the principal environmental dissipation process of chemicals. As such it is a dominant factor determining the persistence and fate of organic chemicals in the environment, and is therefore of critical importance to chemical management and regulation. In this study, we developed in silico methods assessing biodegradability based on ...
MacMartin Douglas G DG 0000-0003-1987-9417 Control and Dynamical Systems , California Institute of Technology , Pasadena , CA 91125 - - 2014
Transfer function tools commonly used in engineering control analysis can be used to better understand the dynamics of El Niño Southern Oscillation (ENSO), compare data with models and identify systematic model errors. The transfer function describes the frequency-dependent input-output relationship between any pair of causally related variables, and can be ...
McCullough Erin L EL Division of Biological Sciences, University of Montana, Missoula, MT 59812 - - 2014
The shapes of sexually selected weapons differ widely among species, but the drivers of this diversity remain poorly understood. Existing explanations suggest weapon shapes reflect structural adaptations to different fighting styles, yet explicit tests of this hypothesis are lacking. We constructed finite element models of the horns of different rhinoceros ...
Nunn Charles L CL Department of Human Evolutionary Biology, Harvard University, Cambridge, MA, 02138; Department of Evolutionary Anthropology, Duke University, Durham, NC, 27708. - - 2014
For traits showing correlated evolution, one trait may evolve more slowly than the other, producing evolutionary lag. The species-pairs evolutionary lag test (SPELT) uses an independent contrasts-based approach to detect evolutionary lag on a phylogeny. We investigated the statistical performance of SPELT in relation to degree of lag, sample size ...
Hall Benjamin A BA Microsoft Research, 21 Station Road, Cambridge CB1 2FB, UK - - 2014
Caenorhabditis elegans vulval development is a paradigm system for understanding cell differentiation in the process of organogenesis. Through temporal and spatial controls, the fate pattern of six cells is determined by the competition of the LET-23 and the Notch signalling pathways. Modelling cell fate determination in vulval development using state-based ...
Mashanov Gregory I GI Division of Physical Biochemistry, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK - - 2014
The analysis of single molecule imaging experiments is complicated by the stochastic nature of single molecule events, by instrument noise and by the limited information which can be gathered about any individual molecule observed. Consequently, it is important to cross check experimental results using a model simulating single molecule dynamics ...
Colin R R http://orcid.org/0000-0001-9051-8003 The Rowland Institute at Harvard, 100 Edwin H. Land Boulevard, Cambridge, MA 02142, USA - - 2014
Swimming bacteria explore their environment by performing a random walk, which is biased in response to, for example, chemical stimuli, resulting in a collective drift of bacterial populations towards 'a better life'. This phenomenon, called chemotaxis, is one of the best known forms of collective behaviour in bacteria, crucial for ...
Kochi Naomi - - 2014
BackgroundAn algebraic method for information fusion based on nonadditive set functions is used to assess the joint contribution of Boolean network attributes to the sensitivity of the network to individual node mutations. The node attributes or characteristics under consideration are: in-degree, out-degree, minimum and average path lengths, bias, average sensitivity ...
Ventz Steffen S Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute and Department of Biostatistics Harvard School of Public Health, Boston, Massachusetts, 02115, - - 2014
Frequentist concepts, such as the control of the type I error or the false discovery rate, are well established in the medical literature and often required by regulators. Most Bayesian designs are defined without explicit considerations of frequentist characteristics. Once the Bayesian design is structured, statisticians use simulations and adjust ...
Yücel Meryem A MA MGH/HST Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, 02129, MA, USA. Electronic address: - - 2014
Calibrated functional Magnetic Resonance Imaging (fMRI) is a widely used method to investigate brain function in terms of physiological quantities such as the cerebral metabolic rate of oxygen (CMRO2). The first and one of the most common methods of fMRI calibration is hypercapnic calibration. This is achieved via simultaneous measures ...
England Bryant R BR Omaha VAMC and Nebraska Arthritis Outcomes Research Center, University of Nebraska Medical Center, Omaha, - - 2014
Objective: There is no consensus on which comorbidity index is optimal for rheumatologic health outcomes research. We compared a new Rheumatic Disease Comorbidity Index (RDCI) with the Charlson-Deyo index (CDI), Elixhauser Total Score (ETS), Elixhauser Point System (EPS), Functional Comorbidity Index (FCI), and a simple comorbidity count (COUNT) using a ...
Terry Alan J AJ Division of Mathematics, University of Dundee, Dundee, DD1 4HN, UK. Electronic address: - - 2014
We study a model for biological pest control (or "biocontrol") in which a pest population is controlled by a program of periodic releases of a fixed yield of predators that prey on the pest. Releases are represented as impulsive increases in the predator population. Between releases, predator-pest dynamics evolve according ...
Castro Susana S University of Roehampton, School of Education , London , UK - - 2014
Abstract Objective: This study aims to identify functioning categories of the International Classification of Functionality, Disability and Health for Children and Youth covered by the Griffiths developmental scales and the Schedule of Growing Skills II (SGS-II), as well as to analyse levels of agreement between coders when assigning its items ...
Shinnawi Rami R The Sohnis Research Laboratory for Cardiac Electrophysiology and Regenerative Medicine, Rappaport Faculty of Medicine and Research Institute, Technion - Israel Institute of Technology, POB 9649, Haifa, 31096, - - 2014
The study of inherited cardiac disorders is hampered by the lack of suitable in vitro human cardiac disease models and relevant functional assays. A potential solution to this cell-sourcing challenge may be the recently described human induced pluripotent stem cell (hiPSC) technology. Pioneering studies were successful in establishing patient-specific, hiPSC-derived ...
Ding Jie J Department of Urology, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Yangpu, Shanghai 200092, P.R. - - 2014
Experimental animal models are crucial in the study of biological behavior and pathological development of cancer, and evaluation of the efficacy of novel therapeutic or preventive agents. A variety of animal models that recapitulate human urothelial cell carcinoma have thus far been established and described, while models generated by novel ...
Campos Mauro - - 2014
Bare bones particle swarm optimization (BBPSO) is a swarm algorithm that has shown potential for solving single-objective unconstrained optimization problems over continuous search spaces. However, it suffers of the premature convergence problem that means it may get trapped into a local optimum when solving multimodal problems. In order to address ...
Muir Ryan D RD Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN 47907, - - 2014
Experiments and modeling are described to perform spectral fitting of multi-threshold counting measurements on a pixel-array detector. An analytical model was developed for describing the probability density function of detected voltage in X-ray photon-counting arrays, utilizing fractional photon counting to account for edge/corner effects from voltage plumes that spread across ...
Jiang Yuxiang Y Department of Computer Science and Informatics, Indiana University, Bloomington, IN, USA, Department of Microbiology and Department of Computer Science and Software Engineering, Miami University, Oxford, OH, - - 2014
The automated functional annotation of biological macromolecules is a problem of computational assignment of biological concepts or ontological terms to genes and gene products. A number of methods have been developed to computationally annotate genes using standardized nomenclature such as Gene Ontology (GO). However, questions remain about the possibility for ...
Collier James H JH Clayton School of Information Technology, Monash University, Clayton, VIC 3800, Australia and Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA 16802, - - 2014
Progress in protein biology depends on the reliability of results from a handful of computational techniques, structural alignments being one. Recent reviews have highlighted substantial inconsistencies and differences between alignment results generated by the ever-growing stock of structural alignment programs. The lack of consensus on how the quality of structural ...
Xiong Shunshun S Institute of Nuclear Physics and Chemistry, China Academy of Engineering Physics, Mianyang, Sichuan 621900, P. R. China. - - 2014
A new tetrazolate zeolite-like framework with a diamond topology, UTSA-49, was synthesized. UTSA-49 shows high selectivity for CO2/CH4 and CO2/N2 indicating a synergistic effect of the suitable pore size/shape and functional groups.
Qin Hua-Li HL Department of Pharmaceutical Engineering, School of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, 205 Luoshi Rd., Wuhan 430070 (P. R. China), Fax: (+86) 2787749379. - - 2014
First-principles modelling of the diastereomeric transition states in the enantiodiscrimination stage of the catalytic cycle can reveal intimate details about the mechanism of enantioselection. This information can be invaluable for further improvement of the catalytic protocols by rational design. Herein, we present a density functional theory (IEFPCM/PBE0/DGDZVP level of theory) ...
Ji Hyunjun H Graduate School of EEWS, KAIST, Daejeon 305-701 (Republic of - - 2014
The significant amount of attention that has been directed toward metal-organic frameworks (MOFs) for a wide spectrum of applications can be attributed to their variety and tunability, which are precisely the aspects that computational modeling can offer by systematically exploring the chemical space. In this minireview, we describe density functional ...
Višnjar Tanja T Faculty of Medicine, Institute of Cell Biology, University of Ljubljana, Vrazov trg 2, 1000, Ljubljana, - - 2014
The urinary tract is exposed to a variety of possible injures that may lead to organ damage or loss, and thus, the establishment of valid in vitro urothelial models to study the mechanism of drug candidates is necessary. This study is the first to investigate the effect of chitosan on ...
Li Hongjian - - 2014
State-of-the-art protein-ligand docking methods are generally limited by the traditionally lowaccuracy of their scoring functions, which are used to predict binding affinity and thus vital fordiscriminating between active and inactive compounds. Despite intensive research over the years,classical scoring functions have reached a plateau in their predictive performance. These assume apredetermined ...
Stinear C M CM Clinical Neuroscience Laboratory, Department of Medicine, University of Auckland, Private Bag, 92019 Auckland, New Zealand; Centre for Brain Research, University of Auckland, Private Bag, 92019 Auckland, New Zealand. Electronic address: - - 2014
Being able to predict an individual's potential for recovery of motor function after stroke may facilitate the use of more effective targeted rehabilitation strategies, and management of patient expectations and goals. This review summarises developments since 2010 of approaches based on clinical, neurophysiological and neuroimaging measures for predicting individual patients' ...
Valsson Omar O Department of Chemistry and Applied Biosciences, ETH Zurich and Facoltà di Informatica, Instituto di Scienze Computationali, Università della Svizzera italiana, Via Giuseppe Buffi 13, CH-6900 Lugano, - - 2014
The ability of widely used sampling methods, such as molecular dynamics or Monte Carlo simulations, to explore complex free energy landscapes is severely hampered by the presence of kinetic bottlenecks. A large number of solutions have been proposed to alleviate this problem. Many are based on the introduction of a bias ...
Krůšek J J Faculty of Electrical Engineering Czech Technical University, Prague, Czech Republic. - - 2014
This paper is devoted to yet unpublished electrode-less methods (ELM) of cell layers impedance measurement based on transformer principle. The main advantage of ELM is elimination uncertainties caused by interface between electrodes and measured electrolyte. The method of avoiding distortion caused by non-ideal transformer transfer function ("deconvolution") and errors caused ...
Langs Georg G Computer Science and Artificial Intelligence Lab, Massachusetts Institute of Technology, Cambridge, MA, USA; Computational Imaging Research Lab, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria. Electronic address: - - 2014
In this paper we construct an atlas that summarizes functional connectivity characteristics of a cognitive process from a population of individuals. The atlas encodes functional connectivity structure in a low-dimensional embedding space that is derived from a diffusion process on a graph that represents correlations of fMRI time courses. The ...
Trépanier Sarah-Geneviève - - 2014
Drawing on self-determination theory, this study proposes and tests a model investigating the role of basic psychological need satisfaction in relation to workplace bullying and employee functioning (burnout, work engagement, and turnover intention). For this study, data were collected at 2 time points, over a 12-month period, from a sample ...
Aeberhard William H WH Research Center for Statistics and Geneva School of Economics and Management, University of Geneva, Geneva, Switzerland; Sydney School of Public Health, University of Sydney, Sydney, - - 2014
A popular way to model overdispersed count data, such as the number of falls reported during intervention studies, is by means of the negative binomial (NB) distribution. Classical estimating methods are well-known to be sensitive to model misspecifications, taking the form of patients falling much more than expected in such ...
Warrington Nicole M - - 2014
Abstract Genome-wide association studies have been successful in uncovering novel genetic variants that are associated with disease status or cross-sectional phenotypic traits. Researchers are beginning to investigate how genes play a role in the development of a trait over time. Linear mixed effects models (LMM) are commonly used to model ...
Heath Andrew C AC Department of Psychiatry 8134, Washington University School of Medicine, Midwest Alcoholism Research Center, 4560 Clayton Avenue, Suite 1000, St Louis, MO, 63110, USA, - - 2014
The authors review past work on modeling human mate selection, and suggest, using illustrations from existing literature on the impact of alcoholism on relationship formation and dissolution and reproduction, that the challenges of adequately characterizing human mate selection have not yet been overcome. Some paths forwards are suggested.
Gill Pamela G PG School of Earth Sciences, University of Bristol, Wills Memorial Building, Queens Road, Bristol BS8 1RJ, - - 2014
The origin and radiation of mammals are key events in the history of life, with fossils placing the origin at 220 million years ago, in the Late Triassic period. The earliest mammals, representing the first 50 million years of their evolution and including the most basal taxa, are widely considered ...
Galano Annia A Departamento de Química, Universidad Autónoma Metropolitana-Iztapalapa, San Rafael Atlixco 186, Col. Vicentina, Iztapalapa, C. P. 09340, México D. F., - - 2014
The performance of 18 density functional approximations has been tested for a very challenging task, the calculations of rate constants for radical-molecule reactions in aqueous solution. Despite of the many difficulties involved in such an enterprise, six of them provide high quality results, and are recommended to that purpose. They ...
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