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Lee Heeyoung H Department of Food and Nutrition, Sookmyung Women's University, Seoul 140-742, - - 2014
In this study, we developed mathematical models to describe the growth kinetics of Staphylococcus aureus on natural cheeses. A five-strain mixture of Staph. aureus was inoculated onto 15 g of Brie and Camembert cheeses at 4 log CFU/g. The samples were then stored at 4, 10, 15, 25, and 30 °C for 2-60 d, ...
- - 2014
The ab initio cyclic cluster model is presented by Michael F. Peintinger and Thomas Bredow on page 839 (DOI: 10.1002/jcc.23550). The similarity between this Γ-point and molecular approaches allows in principle the application of sophisticated post Hartree-Fock methods to solid-state problems. The cover background shows the treatment of four-center integrals ...
Mendenhall Chase D CD 1] Center for Conservation Biology, Stanford University, Stanford, California 94305, USA [2] Department of Biology, Stanford University, Stanford, California 94305, - - 2014
The equilibrium theory of island biogeography is the basis for estimating extinction rates and a pillar of conservation science. The default strategy for conserving biodiversity is the designation of nature reserves, treated as islands in an inhospitable sea of human activity. Despite the profound influence of islands on conservation theory ...
Dewitt Stephen Joseph - - 2014
Films grown through the anodic oxidation of metal substrates are promising for applications ranging from solar cells to medical devices, but the underlying mechanisms of anodic growth are not fully understood. To provide better understanding of these mechanisms, we present a new one-dimensional model for the anodization of aluminum. In ...
Killeen Gerry F - - 2014
Eliminating malaria from highly endemic settings will require unprecedented levels of vector control. To suppress mosquito populations, vector control products targeting their blood hosts must attain high biological coverage of all available sources, rather than merely high demographic coverage of a targeted resource subset, such as humans while asleep indoors. ...
Karunasena H C P HC School of Chemistry, Physics and Mechanical Engineering, Faculty of Science and Engineering, Queensland University of Technology, 2-George Street, Brisbane, QLD 4001, Australia. - - 2014
Fundamental understanding on microscopic physical changes of plant materials is vital to optimize product quality and processing techniques, particularly in food engineering. Although grid-based numerical modelling can assist in this regard, it becomes quite challenging to overcome the inherited complexities of these biological materials especially when such materials undergo critical ...
Eddie Sharon L SL Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60607, - - 2014
Preclinical toxicity testing in animal models is a cornerstone of the drug development process, yet it is often unable to predict adverse effects and tolerability issues in human subjects. Species-specific responses to investigational drugs have led researchers to utilize human tissues and cells to better estimate human toxicity. Unfortunately, human ...
Wang Yao Y Beijing National Laboratory for Molecular Sciences and the Key Laboratory of Polymer Chemistry and Physics of the Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing, - - 2014
The extracellular matrix is mimicked by a novel dendrimer-based hydrogel, which exhibits a highly interconnected porous network, enhanced mechanical stiffness, and a low swelling ratio. The hydrogel system supports the proliferation and differentiation of mesenchymal stem cells without any cytotoxic effects. This dendrimer-based hydrogel may serve as a model for ...
Svensson Carl-Magnus CM Applied Systems Biology, Leibniz Institute for Natural Product Research and Infection Biology, Hans-Knöll-Institute (HKI), Jena, Germany; Frankfurt Institute for Advanced Studies (FIAS), Goethe-University Frankfurt, Frankfurt am Main, - - 2014
Personalized medicine is a modern healthcare approach where information on each person's unique clinical constitution is exploited to realize early disease intervention based on more informed medical decisions. The application of diagnostic tools in combination with measurement evaluation that can be performed in a reliable and automated fashion plays a ...
Christie Christopher R CR Department of Chemical Engineering, VA Polytechnic Institute and State University, Blacksburg, VA - - 2014
Context: A control engineering perspective provides a framework for representing important mechanistic details of the calcium (Ca) regulatory system efficiently. The resulting model facilitates the testing of hypotheses about mechanisms underlying the emergence of known calcium-related pathologies. Objective: The objective of this work is to develop a comprehensive computational model ...
Baycin Hizal Deniz - - 2014
Protein glycosylation serves critical roles in the cellular and biological processes of many organisms. Aberrant glycosylation has been associated with many illnesses such as hereditary and chronic diseases like cancer, cardiovascular diseases, neurological disorders, and immunological disorders. Emerging mass spectrometry (MS) technologies that enable the high-throughput identification of glycoproteins and ...
Zuha Raja Muhammad RM Forensic Science Program, School of Diagnostic and Applied Health Sciences, Faculty of Health Sciences, Universiti Kebangsaan Malaysia (National University of Malaysia), Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia, - - 2014
Cosmopolitan scuttle fly, Megaselia scalaris (Loew) (Diptera: Phoridae) is one of the commonest forensic species recorded colonizing human corpse indoors and in concealed environment. The occurrence of this species in such environments provides a higher evidential value to assist estimation of postmortem interval (PMI) compared to other forensically important dipterans. ...
Liu Jun J State Key Laboratory of Biocontrol and Key Laboratory of Biodiversity Dynamics and Conservation of Guangdong Higher Education Institutes, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, PR - - 2014
Recent molecular surveys have advanced our understanding of the forces shaping the large-scale ecological distribution of microbes in Earth's extreme habitats, such as hot springs and acid mine drainage. However, few investigations have attempted dense spatial analyses of specific sites to resolve the local diversity of these extraordinary organisms and ...
Dallai Romano R Department of Life Sciences, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy. Electronic address: - - 2014
The main characteristics of the sperm structure of Hexapoda are reported in the review. Data are dealing with the process of spermatogenesis, including the aberrant models giving rise to a reduced number of sperm cells. The sperm heteromorphism and the giant sperm exceeding the usual sperm size for length and ...
Mercier Sarah M SM Crucell Holland BV, Process Development Department, Archimedesweg 4-6, 2333 CN Leiden, The - - 2014
Increasingly elaborate and voluminous datasets are generated by the (bio)pharmaceutical industry and are a major challenge for application of PAT and QbD principles. Multivariate data analysis (MVDA) is required to delineate relevant process information from large multi-factorial and multi-collinear datasets. Here the key role of MVDA for industrial (bio)process data ...
Kliethermes Stephanie S Department of Medicine, Stritch School of Medicine, Loyola University Chicago, 2160 S. First Ave, Maywood, IL 60153, - - 2014
Longitudinal growth patterns are routinely seen in medical studies where individual growth and population growth are followed up over a period of time. Many current methods for modeling growth presuppose a parametric relationship between the outcome and time (e.g., linear and quadratic); however, these relationships may not accurately capture growth ...
Tsang John S JS Trans-NIH Center for Human Immunology, Autoimmunity and Inflammation, National Institutes of Health, Bethesda, MD 20892, USA; Systems Genomics and Bioinformatics Unit, Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: - - 2014
A major goal of systems biology is the development of models that accurately predict responses to perturbation. Constructing such models requires the collection of dense measurements of system states, yet transformation of data into predictive constructs remains a challenge. To begin to model human immunity, we analyzed immune parameters in ...
Law Simon S Australian Research Council Centre of Excellence in Plant Energy Biology, University of Western Australia, 35 Stirling Highway, Crawley, Western Australia, 6009, - - 2014
Mitochondria occupy a central role in the eukaryotic cell. In addition to being major sources of cellular energy, mitochondria are also involved in a diverse range of functions including signalling, the synthesis of many essential organic compounds and a role in programmed cell death. The active proliferation and differentiation of ...
Wilding Jennifer L JL Authors' Affiliation: Department of Oncology, Cancer and Immunogenetics Laboratory, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United - - 2014
Despite the millions of dollars spent on target validation and drug optimization in preclinical models, most therapies still fail in phase III clinical trials. Our current model systems, or the way we interpret data from them, clearly do not have sufficient clinical predictive power. Current opinion suggests that this is ...
Kurashima Akira A Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan, - - 2014
A new combination and a new species of onchobothriid tapeworm are described from triakid sharks. We found Platybothrium xiamenensis Wang & Yang, 2001 and Erudituncus musteli (Yamaguti, 1952) from Hemitriakis japanica (Müller & Henle). Based on the morphology of the hooks P. xiamenensis is transferred to the genus Erudituncus Healy, ...
Rojas-Aguirre Yareli Y Instituto de Química, Universidad Nacional Autónoma de México, 04510 , Mexico City, - - 2014
Understanding the relationship between the chemical structure of bioactive compounds and Caco-2 permeability is of major importance in modern drug discovery. The purpose of this work was to characterize systematically the Caco-2 permeability landscape of a benchmark dataset of 100 molecules using a novel approach based on the emerging concept ...
Tan Chin Wee - - 2014
Wnt/beta-catenin signaling is involved in different stages of mammalian development and implicated in various cancers (e.g. colorectal cancer). Recent experimental and computational studies have revealed characteristics of the pathway, however a cell-specific spatial perspective is lacking. In this study, a novel 3D confocal quantitation protocol is developed to acquire spatial ...
White J J Centre for Sustainable Tropical Fisheries and Aquaculture & School of Earth & Environmental Sciences, James Cook University, Townsville, Queensland, 4811, - - 2014
Estimates of life-history parameters were made for shark-like batoids of conservation concern Rhynchobatus spp. (Rhynchobatus australiae, Rhynchobatus laevis and Rhynchobatus palpebratus) and Glaucostegus typus using vertebral ageing. The sigmoid growth functions, Gompertz and logistic, best described the growth of Rhynchobatus spp. and G. typus, providing the best statistical fit and ...
Jauhiainen Alexandra A Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, - - 2014
In metabolomics the goal is to identify and measure the concentrations of different metabolites (small molecules) in a cell or a biological system. The metabolites form an important layer in the complex metabolic network, and the interactions between different metabolites are often of interest. It is crucial to perform proper ...
Wawer Mathias J MJ 1Center for the Science of Therapeutics, Broad Institute, Cambridge, MA, - - 2014
Understanding the structure-activity relationships (SARs) of small molecules is important for developing probes and novel therapeutic agents in chemical biology and drug discovery. Increasingly, multiplexed small-molecule profiling assays allow simultaneous measurement of many biological response parameters for the same compound (e.g., expression levels for many genes or binding constants against ...
Singh Shantanu S 1Imaging Platform, Broad Institute of MIT and Harvard, Cambridge, MA, - - 2014
Target-based high-throughput screening (HTS) has recently been critiqued for its relatively poor yield compared to phenotypic screening approaches. One type of phenotypic screening, image-based high-content screening (HCS), has been seen as particularly promising.In this article, we assess whether HCS is as high content as it can be. We analyze HCS ...
Rolland-Lagan Anne-Gaëlle AG University of - - 2014
The analysis of biological shapes has applications in many areas of biology, and tools exist to quantify organ shape and detect shape differences between species or among variants. However, such measurements do not provide any information about the mechanisms of shape generation. Quantitative data on growth patterns may provide insights ...
Bennetts Craig J CJ a Computational Biomodeling (CoBi) Core, Department of Biomedical Engineering , Lerner Research Institute , Cleveland Clinic, Cleveland , OH 44195 , - - 2014
Finite element analysis provides a means of describing cellular mechanics in tissue, which can be useful in understanding and predicting physiological and pathological changes. Many prior studies have been limited to simulations of models containing single cells, which may not accurately describe the influence of mechanical interactions between cells. It ...
Barigye Stephen J SJ Unit of Computer-Aided Molecular "Biosilico" Discovery and Bioinformatic Research (CAMD-BIR Unit), Faculty of Chemistry-Pharmacy, Universidad Central "Martha Abreu" de Las Villas, 54830 , Santa Clara, Villa Clara, Cuba, - - 2014
This report offers a chronological review of the most relevant applications of information theory in the codification of chemical structure information, through the so-called information indices. Basically, these are derived from the analysis of the statistical patterns of molecular structure representations, which include primitive global chemical formulae, chemical graphs, or ...
Zhou Chang-Fu - - 2014
Manchurochelys manchoukuoensis is an emblematic turtle from the Cretaceous Yixian Formation of Liaoning, China, a geological rock unit that is famous for yielding perfectly preserved skeletons of fossil vertebrates, including that of feathered dinosaurs. Manchurochelys manchoukuoensis was one of the first vertebrates described from this fauna, also known as the ...
Unterberger Michael J MJ Institute of Biomechanics, Graz University of Technology, Kronesgasse 5-I, 8010 , Graz, - - 2014
The protein actin is a part of the cytoskeleton and, therefore, responsible for the mechanical properties of the cells. Starting with the single molecule up to the final structure, actin creates a hierarchical structure of several levels exhibiting a remarkable behavior. The hierarchy spans several length scales and limitations in ...
Mengoni M M a Department of Aerospace and Mechanical Engineering, MN2L , University of Liege (ULg) , Liège , - - 2014
The purpose of this work was to propose an enhancement of Doblaré and García's internal bone remodelling model based on the continuum damage mechanics (CDM) theory. In their paper, they stated that the evolution of the internal variables of the bone microstructure, and its incidence on the modification of the ...
Mišić Bratislav B Rotman Research Institute of Baycrest Centre, Toronto, - - 2014
Given their unique connectivity, a primary function of brain networks must be to transfer and integrate information. Therefore, the way in which information is integrated by individual nodes of the network may be an informative aspect of cognitive processing. Here we present a method inspired by telecommunications research that utilizes ...
Rosenbaum Miriam A MA Institute of Applied Microbiology-Microbial Electrocatalysis, RWTH Aachen University, Worringerweg 1, 52074 Aachen, Germany. Electronic address: - - 2014
In many biotechnological areas, metabolic engineering and synthetic biology have become core technologies for biocatalyst development. Microbial electrocatalysis for biochemical and fuel production is still in its infancy and reactions rates and the product spectrum are currently very low. Therefore, molecular engineering strategies will be crucial for the advancement and ...
Peng Lei L Center for Nanotechnology in Drug Delivery, Division of Molecular Pharmaceutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, - - 2014
The aims of these studies were to establish an orthotopic non-small-cell lung cancer (NSCLC) mouse model, and to investigate the therapeutic efficacy of lipid-based nanoparticles (NPs) containing 2'-(2-bromohexadecanoyl)-docetaxel (Br-C16-DX) in this new model. A novel orthotopic NSCLC model was established in nude mice through dorsal side injection of luciferase-expressing A549 ...
Hohl Tobias M TM Department of Medicine, Infectious Diseases Service, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, Box 9, New York, NY 10075. Electronic address: - - 2014
Fungi represent emerging infectious threats to human populations worldwide. Mice and other laboratory animals have proved invaluable in modeling clinical syndromes associated with superficial and life-threatening invasive mycoses. This review outlines salient features of common vertebrate animal model systems to study fungal pathogenesis, host antifungal immune responses, and antifungal compounds.
Palmisano Alida - - 2014
Motivation: Building models of molecular regulatory networks is challenging not just because of the intrinsic difficulty of describing complex biological processes. Writing a model is a creative effort that calls for more flexibility and interactive support than offered by many of today's biochemical model editors. Our model editor MSMB - ...
Harbert Robert S RS Cornell University, Department of Plant Biology, 412 Mann Library, Cornell University, Ithaca, New York 14853 - - 2014
Polyploid plants, when compared with diploids, show similar molecular, morphological, physiological, and ecological tendencies across unrelated groups, but the degree to which these form "rules" of polyploid evolution are unclear. The Glycine (Leguminosae) allopolyploid complex affords the opportunity to test whether polyploidy in similar genetic backgrounds produces similar effects on ...
Babanova Sofia S Chemical and Nuclear Engineering Department, Center for Emerging Energy Technologies, University of New Mexico, Albuquerque, NM 87131, USA. plamen@unm.edu - - 2014
The last decade of research has made significant strides toward practical applications of Microbial Fuel Cells (MFCs); however, design improvements and operational optimization cannot be realized without equally considering engineering designs and biological interfacial reactions. In this study, the main factors contributing to MFCs' overall performance and their influence on ...
Jepson Lauren H LH Systems Neurobiology Laboratories, Salk Institute for Biological Studies, La Jolla, California 92037, Bioengineering Department, University of California, San Diego, La Jolla, California 92093, AGH University of Science and Technology, Faculty of Physics and Applied Computer Science, 30-059, Krakow, Poland, Institute of Photonics, SUPA, University of Strathclyde, Glasgow G4 0NW, United Kingdom, Santa Cruz Institute for Particle Physics, University of California, Santa Cruz, Santa Cruz, California 95064, and Department of Neurosurgery and Hansen Experimental Physics Laboratory, Stanford University, Stanford, California - - 2014
Retinal prostheses electrically stimulate neurons to produce artificial vision in people blinded by photoreceptor degenerative diseases. The limited spatial resolution of current devices results in indiscriminate stimulation of interleaved cells of different types, precluding veridical reproduction of natural activity patterns in the retinal output. Here we investigate the use of ...
Edlund Erik E Complex Systems Group, Department of Energy and Environment, Chalmers University of Technology, SE-41296 Göteborg, Sweden. - - 2014
Patchy colloids are promising candidates for building blocks in directed self-assembly, but large scale synthesis of colloids with controlled surface patterns remains challenging. One potential fabrication method is to self-assemble the surface patterns themselves, allowing complex morphologies to organize spontaneously. For this approach to be competitive, prediction and control of ...
Bush Daniel D Institute of Cognitive Neuroscience, University College London, London WC1N 3AR, United Kingdom, and Institute of Neurology, University College London, London WC1N 3BG, United - - 2014
Grid cells in the rodent medial entorhinal cortex exhibit remarkably regular spatial firing patterns that tessellate all environments visited by the animal. Two theoretical mechanisms that could generate this spatially periodic activity pattern have been proposed: oscillatory interference and continuous attractor dynamics. Although a variety of evidence has been cited ...
Wagner Sarah T ST Institut für Botanik, Technische Universität Dresden, D-01062 Dresden, - - 2014
Background and AimsThe order Piperales has the highest diversity of growth forms among the earliest angiosperm lineages, including trees, shrubs, climbers and herbs. However, within the perianth-bearing Piperales (Asarum, Saruma, Lactoris, Hydnora, Prosopanche, Thottea and Aristolochia), climbing species only occur in the most species-rich genus Aristolochia. This study traces anatomical ...
Verhaegh Wim W Molecular Diagnostics, Philips - - 2014
Increasing knowledge concerning signal transduction pathways as drivers of cancer growth has elicited the development of 'targeted drugs' which inhibit aberrant signaling pathways. They require a companion diagnostic test which identifies the tumor-driving pathway, however, currently available tests like ER protein expression for hormonal treatment of breast cancer, do not ...
Nakaoka Shinji - - 2014
Quantitative measurement for the timings of cell division and death with the application of mathematical models is a standard way to estimate kinetic parameters of cellular proliferation. On the basis of label-based measurement data, several quantitative mathematical models describing short-term dynamics of transient cellular proliferation have been proposed and extensively ...
Doege Claudia A CA Departments of Pathology, Cell Biology, and Neurology and Taub Institute for Alzheimer's Disease and the Aging Brain, Columbia University, New York, New - - 2014
Neurodegenerative disorders of aging represent a growing public health concern. In the United States alone, there are now >5 million patients with Alzheimer's disease (AD), the most common form of dementia. No therapeutic approaches are available that alter the relentless course of AD or other dementias of aging. A major ...
Salas-García Irene - - 2014
Photodynamic therapy (PDT) dosimetric tools are crucial for treatment planning and noninvasive monitoring by means of fluorescence. Present approaches consider usually a 1D problem, a simple photochemical process, or a spatially homogeneous photosensitizer. In this work, a radially resolved superficial photosensitizer fluorescence and 3D photochemical time-dependent PDT model are presented. ...
Sanchez Eric E Institute for Myeloma & Bone Cancer Research, West Hollywood, California, United States of America. Electronic address: - - 2014
The development of the plasma cell tumor (PCT) model was the first widely accepted in vivo model of multiple myeloma (MM). Potter and colleagues used this chemically induced PCT model to study the pathophysiology of malignant plasma cells and also used it to screen anti-MM agents. Two decades later the ...
Huang Can C Department of Mathematics, Michigan State University, East Lansing, MI 48824, United - - 2014
The hepatic insulin signaling mediated by insulin receptor substrates IRS1 and IRS2 plays a central role in maintaining glucose homeostasis under different physiological conditions. Although functions of individual components in the signaling network have been extensively studied, our knowledge is still limited with regard to how the signals are integrated ...
Stringer Chris C Department of Earth Sciences, The Natural History Museum, London, SW7 5BD, UK. Electronic address: - - 2014
Recent revelations that human genomes contain DNA introgressed through interbreeding with archaic populations outside of Africa have led to reassessments of models for the origins of our species. The fact that small portions of the DNA of recent Homo sapiens derive from ancient populations in more than one region of ...
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