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Engbers Ralf R Institute for Computational and Applied Mathematics, Westfälische Wilhelms-Universität (WWU) Münster, Einsteinstrasse 62, Münster 48149, Germany - - 2014
The identification of production functions from data is an important task in the modelling of economic growth. In this paper, we consider a non-parametric approach to this identification problem in the context of the spatial Solow model which allows for rather general production functions, in particular convex-concave ones that have ...
Albi G G Department of Mathematics and Computer Science, University of Ferrara, via Machiavelli 35, Ferrara 44121, - - 2014
The study of formations and dynamics of opinions leading to the so-called opinion consensus is one of the most important areas in mathematical modelling of social sciences. Following the Boltzmann-type control approach recently introduced by the first two authors, we consider a group of opinion leaders who modify their strategy ...
Beck L L CEA, DEN, Service de Recherches de Métallurgie Physique, Laboratoire JANNUS, 91191 Gif-sur-Yvette, France; C2RMF - UMR171 CNRS, Centre de Recherche et de Restauration des Musées de France, Palais du Louvre, Porte des Lions, 14 quai François Mitterrand, 75001 Paris, France. Electronic address: - - 2014
Study of prehistoric art is playing a major role in the knowledge of human evolution. Many scientific methods are involved in this investigation including chemical analysis of pigments present on artefacts or applied to cave walls. In the past decades, the characterization of coloured materials was carried on by taking ...
Precup Radu-Emil - - 2014
This paper suggests a new generation of optimal PI controllers for a class of servo systems characterized by saturation and dead zone static nonlinearities and second-order models with an integral component. The objective functions are expressed as the integral of time multiplied by absolute error plus the weighted sum of ...
Cervellera Cristiano - - 2014
Local linear regression models, a kind of nonparametric structures that locally perform a linear estimation of the target function, are analyzed in the context of empirical risk minimization (ERM) for function learning. The analysis is carried out with emphasis on geometric properties of the available data. In particular, the discrepancy ...
Munoz-Gonzalez Luis - - 2014
Standard Gaussian process regression (GPR) assumes constant noise power throughout the input space and stationarity when combined with the squared exponential covariance function. This can be unrealistic and too restrictive for many real-world problems. Nonstationarity can be achieved by specific covariance functions, though prior knowledge about this nonstationarity can be ...
Sánchez-Márquez Jesús J Departamento de Química-Física, Facultad de Ciencias, Campus Universitario Río San Pedro, Universidad de Cádiz, 11510, Puerto Real, Cádiz, Spain, - - 2014
A new software (UCA-FUKUI) has been developed to facilitate the theoretical study of chemical reactivity. This program can calculate global parameters like hardness, softness, philicities, and Fukui condensed functions, and also local parameters from the condensed functions. To facilitate access to the program we have developed a very easy-to-use interface. ...
Bookstein Fred L FL Department of Anthropology, University of Vienna, Austria; Department of Statistics, University of Washington, Seattle, - - 2014
A frequent concern in today's functional morphology is the relation of a landmark configuration to some a priori index or suite of indices of function. When an index is itself a generic mathematical or biomechanical shape function of landmark locations, meaning a dimensionless expression that has a nonzero gradient everywhere ...
Green David J DJ Department of Anatomy, Midwestern University, 555 31st Street, Downers Grove, IL, - - 2014
Recent discoveries of early hominin scapulae from Ethiopia (Dikika, Woranso-Mille) and South Africa (Malapa) have motivated new examinations of the relationship between scapular morphology and locomotor function. In particular, infraspinous fossa shape has been shown to significantly differ among hominoids. However, this region presents relatively few homologous landmarks, such that ...
Kalus Stefanie S Department of Statistics, Ludwig-Maximilians-University, Ludwigstr. 33, 80539, Munich, - - 2014
Functional magnetic resonance imaging (fMRI) activation detection within stimulus-based experimental paradigms is conventionally based on the assumption that activation effects remain constant over time. This assumption neglects the fact that the strength of activation may vary, for example, due to habituation processes or changing attention. Neither the functional form of ...
Cooke Siobhán B SB Department of Anthropology, Northeastern Illinois University, Chicago, IL; New York Consortium in Evolutionary Primatology Morphometrics Group, New York, - - 2014
Geometric morphometrics (GM) has increasingly become an important tool in assessing and studying shape variation in a wide variety of taxa. While the GM toolkit has unparalleled power to quantify shape, its uses in studies of functional morphology have been questioned. Here we assess the state of the field of ...
Lewton Kristi L KL Department of Anatomy & Neurobiology, Boston University School of Medicine, 72 E. Concord St., Boston, MA, 02118, USA; Department of Human Evolutionary Biology, Harvard University, 11 Divinity Ave, Cambridge, MA, 02138, - - 2014
The pelvic girdle is a complex structure with a critical role in locomotion, but efforts to model the mechanical effects of locomotion on its shape remain difficult. Traditional approaches to understanding form and function include univariate adaptive hypothesis-testing derived from mechanical models. Geometric morphometric (GM) methods can yield novel insight ...
Roy Ambrish A Center for the Study of Systems Biology, School of Biology, Georgia Institute of Technology, Atlanta, GA 30076, - - 2014
Shape-based alignment of small molecules is a widely used approach in computer-aided drug discovery. Most shape-based ligand structure alignment applications, both commercial and freely available ones, use the Tanimoto Coefficient or similar functions for evaluating molecular similarity. Major drawbacks of using such functions is the size dependence of the score ...
Thomsen Mads S MS Marine Ecology Research Group, School of Biological Sciences, University of Canterbury, Private Bag 4800, Christchurch, New Zealand; UWA Oceans Institute and School of Plant Biology, University of Western Australia, Hackett Drive, Crawley, 6009, WA, - - 2014
In a stimulating paper Lyons et al. (2014) reported results from meta-analyses on effects of bloom-forming seaweeds on ecosystem properties, emphasizing the importance of these impacts in coastal ecosystems. The main conclusions were that (i) effects of seaweeds were "highly variable" and (ii) marine invertebrates were "particularly sensitive to blooms, suffering ...
Shou Haochang H Department of Biostatistics and Epidemiology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, - - 2014
Motivated by modern observational studies, we introduce a class of functional models that expand nested and crossed designs. These models account for the natural inheritance of the correlation structures from sampling designs in studies where the fundamental unit is a function or image. Inference is based on functional quadratics and ...
Graziani Rebecca R Università Commerciale Luigi Bocconi, Milan, - - 2014
The effect of a targeted agent on a cancer patient's clinical outcome putatively is mediated through the agent's effect on one or more early biological events. This is motivated by pre-clinical experiments with cells or animals that identify such events, represented by binary or quantitative biomarkers. When evaluating targeted agents ...
Vlasblom James J Department of Biochemistry, University of Regina, 3737 Wascana Parkway, Regina, SK S4S0A2, - - 2014
The model bacterium Escherichia coli is among the best studied prokaryotes, yet nearly half of its proteins are still of unknown biological function. This is despite a wealth of available large-scale physical and genetic interaction data. To address this, we extended the GeneMANIA function prediction web application developed for model ...
Walsh Jesse R - - 2014
BackgroundBioCyc databases are an important resource for information on biological pathways and genomic data. Such databases represent the accumulation of biological data, some of which has been manually curated from literature. An essential feature of these databases is the continuing data integration as new knowledge is discovered. As functional annotations ...
Meng Xuan-Yu XY Institute of Quantitative Biology and Medicine, Jiangsu Provincial Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou 215123, China. - - 2014
Growing experimental evidences suggest that dimerization and oligomerization are important for G Protein-Coupled Receptors (GPCRs) function. The detailed structural information of dimeric/oligomeric GPCRs would be very important to understand their function. Although it is encouraging that recently several experimental GPCR structures in oligomeric forms have appeared, experimental determination of GPCR ...
Brun-Usan M M Genomics, Bioinformatics and Evolution, Departament de Genètica i Microbiologia, Universitat Autònoma de Barcelona, Barcelona, - - 2014
What proportion of the traits of individuals has been optimally shaped by natural selection and what has not? Here, we estimate the maximal number of those traits using a mathematical model for natural selection in multitrait organisms. The model represents the most ideal conditions for natural selection: a simple genotype-phenotype ...
Arbour J H JH Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, ON, - - 2014
Morphological, lineage and ecological diversity can vary substantially even among closely related lineages. Factors that influence morphological diversification, especially in functionally relevant traits, can help to explain the modern distribution of disparity across phylogenies and communities. Multivariate axes of feeding functional morphology from 75 species of Neotropical cichlid and a ...
Li Zitong Z University of - - 2014
Quantitative trait loci (QTL) mapping of wood properties in conifer species has focused on single time point measurements or on trait means based on heterogeneous wood samples (e.g. increment cores) thus ignoring systematic within-tree trends. In this study, functional QTL mapping was performed for a set of important wood properties ...
Saha Chiranjib - - 2014
This paper proposes a novel fuzzy rule-based penalty function approach for solving single-objective nonlinearly constrained optimization problems. Of all the existing state-of-the-art constraint handling techniques, the conventional method of penalty can be easily implemented because of its simplicity but suffers from the lack of robustness. To mitigate the problem of ...
Roshan A A MRC Cancer Cell Unit, Hutchison-MRC Research Centre, Cambridge CB2 2XZ, - - 2014
Biological tools such as genetic lineage tracing, three-dimensional confocal microscopy and next-generation DNA sequencing are providing new ways to quantify the distribution of clones of normal and mutated cells. Understanding population-wide clone size distributions in vivo is complicated by multiple cell types within observed tissues, and overlapping birth and death ...
Cervera Javier J Departament de Termodinàmica, Universitat de València, Burjassot 46100, Spain - - 2014
The interplay between cooperativity and diversity is crucial for biological ensembles because single molecule experiments show a significant degree of heterogeneity and also for artificial nanostructures because of the high individual variability characteristic of nanoscale units. We study the cross-effects between cooperativity and diversity in model threshold ensembles composed of ...
Read Mark M Department of Electronics, University of York, York YO10 5GW, UK - - 2014
We present a framework to assist the diagrammatic modelling of complex biological systems using the unified modelling language (UML). The framework comprises three levels of modelling, ranging in scope from the dynamics of individual model entities to system-level emergent properties. By way of an immunological case study of the mouse ...
Matoz-Fernandez D A DA Departamento de Física, Instituto de Física Aplicada, Universidad Nacional de San Luis-CONICET, Ejército de los Andes 950, D5700BWS San Luis, Argentina. - - 2014
The statistical thermodynamics of polyatomic species mixtures adsorbed on two-dimensional lattices was developed based on generalization of the semiempirical approximation for the adsorption of single components [Romá, F. et al., Langmuir, 2006, 22, 3192-3197]. In this scheme, the partial adsorption isotherms are obtained using a correction function C[combining tilde], which ...
Nouri-Mahdavi Kouros K The Jules Stein Eye Institute, David Geffen School of Medicine at UCLA, Los Angeles, California, - - 2014
Glaucoma is a progressive optic neuropathy. Hence, most glaucomatous eyes demonstrate signs of deterioration over time despite what may appear to be adequate treatment. The main goal of glaucoma treatment is to slow the rate of disease so that patients can prolong their functional vision. Therefore, it is important for ...
Proud Elizabeth E Department of Physiotherapy, School of Health Sciences, The University of Melbourne, 3010, Victoria, Australia. Electronic address: - - 2014
To identify measurement tools used for upper limb evaluation in people with Parkinson's disease (PD), to summarize the content of each tool using the International Classification of Functioning, Disability and Health (ICF), and examine the reliability, validity, clinical utility and responsiveness of the measurement tools specific to this clinical group. ...
van Gils Jan A JA Department of Marine Ecology, NIOZ Royal Netherlands Institute for Sea Research, P.O. Box 59, 1790 AB, Den Burg (Texel), The - - 2014
1.Models relating intake rate to food abundance and competitor densities (generalized functional response models) can predict forager distributions and movements between patches, but we lack understanding of how distributions and small-scale movements by the foragers themselves affect intake rates. 2.Using a state-of-the-art approach based on continuous-time Markov chain dynamics, we ...
Hu Jialu J Department of Mathematics and Computer Science, Freie Universität Berlin, Takustrasse 9, 14195 Berlin, Germany. - - 2014
Sequences and protein interaction data are of significance to understand the underlying molecular mechanism of organisms. Local network alignment is one of key systematic ways for predicting protein functions, identifying functional modules, and understanding the phylogeny from these data. Most of currently existing tools, however, encounter their limitations which are ...
Amsuess Sebastian - - 2014
Functional replacement of upper limbs by means of dexterous prosthetic devices remains a technological challenge. While the mechanical design of prosthetic hands have advanced rapidly, the human-machine interfacing and the control strategies needed for the activation of multiple degrees of freedom are not reliable enough for restoring hand function successfully. ...
Velazquez Miguel A MA a Centre for Biological Sciences , University of Southampton, Southampton General Hospital , Southampton , United - - 2014
Ovarian transvaginal ultrasonography (OTU) has been used world-wide for commercial ovum pick-up programs for in vitro embryo production in elite herds, providing an excellent model for the elucidation of factors controlling bovine oocyte developmental competence. Noninvasive sampling and treatment of ovarian structures is easily accomplished with bovine OTU techniques providing ...
Cirovic Ivana M IM Business Technical College of Vocational Studies, Uzice, - - 2014
Carl Bovill suggested and described a method of generating rhythm in architecture with the help of fractional Brownian functions, as they are mathematical models of natural rhythm. A relationship established in the stated procedure between fractional Brownian functions as models of rhythm, and the observed group of architectural elements, is ...
Spada Elena E Department of Clinical Sciences and Community Health, Unit of Medical Statistics and Biometry, Università degli Studi di Milano, Milan, I-20133, - - 2014
The Extended Mechanistic Growth Function (EMGF) method (Clementi et al. [1999]: Am J Med Genet 87:317-323) is a possible alternative to the Cole and Green LMS method ([1992] Stat Med 11:1305-1319) to construct cross-sectional anthropometric charts. It differs from the technique used by Kuczmarski et al. ([2002]: Vital Health Stat ...
Kamiya Ritsu R 1 Department of Life Science, Faculty of Science, Gakushuin University, 1-5-1 Mejiro, Toshima-ku, Tokyo 171-8588, - - 2014
This review outlines the current knowledge of the functional diversity of axonemal dyneins, as revealed by studies with the model organism Chlamydomonas. Axonemal dyneins, which comprise outer and inner dynein arms, power cilia and flagella beating by producing sliding movements between adjacent outer-doublet microtubules. Outer- and inner-arm dyneins have traditionally ...
Choi Jaedeug - - 2014
Inverse reinforcement learning (IRL) is the problem of inferring the underlying reward function from the expert's behavior data. The difficulty in IRL mainly arises in choosing the best reward function since there are typically an infinite number of reward functions that yield the given behavior data as optimal. Another difficulty ...
You Di - - 2014
Regression plays a major role in many scientific and engineering problems. The goal of regression is to learn the unknown underlying function from a set of sample vectors with known outcomes. In recent years, kernel methods in regression have facilitated the estimation of nonlinear functions. However, two major (interconnected) problems ...
Szymanski Lech - - 2014
We present a comparative theoretical analysis of representation in artificial neural networks with two extreme architectures, a shallow wide network and a deep narrow network, devised to maximally decouple their representative power due to layer width and network depth. We show that, given a specific activation function, models with comparable ...
Wang Yong Y School of Marine Science and Technology, Northwestern Polytechnical University, Xi'an, 710072, - - 2014
This paper presents a detailed study of the high-order superdirectivity of circular sensor arrays, which is aimed at completing the authors' recently proposed analytical superdirectivity model. From the limit expression of the maximum directivity factor, it is shown that the circular arrays possess good potential for directivity improvement. It is ...
Narula Anubhav P S AP International Flavors & Fragrances, 1515 Highway 36, Union Beach, New Jersey 07735, USA. - - 2014
There is a constant need for developing new fragrance ingredients in the flavor and fragrance industry, as it allows perfumers to create unique and differentiating perfumes for fine as well as functional products. Among all the categories of notes used in perfume creation, amber notes are indispensible and ubiquitous in ...
Ji Jun Zhong - - 2014
Studies of functional modules in a Protein-Protein Interaction (PPI) network contribute greatly to theunderstanding of biological mechanisms. With the development of computing science,computational approaches have played an important role in detecting functional modules. We present a new approach using multi-agent evolution for detection of functional modules in PPInetworks. The proposed ...
Paterson Rachel A RA Institute for Global Food Security, School of Biological Sciences, Queen's University Belfast, Belfast, United Kingdom; School of Biology, University of Leeds, Leeds, United - - 2014
Predatory functional responses play integral roles in predator-prey dynamics, and their assessment promises greater understanding and prediction of the predatory impacts of invasive species. Other inter-specific interactions, however, such as parasitism and higher-order predation, have the potential to modify predator-prey interactions and thus the predictive capability of the comparative functional ...
Rockwood Alan L AL Department of Pathology, University of Utah School of Medicine and ARUP Laboratories, Salt Lake City, UT, 84108, USA, - - 2014
Distortions of peaks can occur when one uses the standard method of signal processing of data from the Orbitrap and other FT-based methods of mass spectrometry. These distortions arise because the standard method of signal processing is not a linear process. If one adds two or more functions, such as ...
Ronacher Bernhard B Department of Biology, Behavioral Physiology Group, Humboldt-Universität zu Berlin, 10099, Berlin, Germany, - - 2014
Grasshoppers and crickets independently evolved hearing organs and acoustic communication. They differ considerably in the organization of their auditory pathways, and the complexity of their songs, which are essential for mate attraction. Recent approaches aimed at describing the behavioral preference functions of females in both taxa by a simple modeling ...
Wei Qinglai - - 2014
In this paper, a new iterative adaptive dynamic programming (ADP) algorithm is developed to solve optimal control problems for infinite horizon discrete-time nonlinear systems with finite approximation errors. First, a new generalized value iteration algorithm of ADP is developed to make the iterative performance index function converge to the solution ...
Benadjaoud Mohamed Amine MA Center for Research in Epidemiology and Population Health (CESP) INSERM 1018 Radiation, Epidemiology Group, Villejuif, France; Université Paris sud, Le Kremlin-Bicêtre, France; Institut Gustave Roussy, Villejuif, France. Electronic address: - - 2014
To describe a novel method to explore radiation dose-volume effects. Functional data analysis is used to investigate the information contained in differential dose-volume histograms. The method is applied to the normal tissue complication probability modeling of rectal bleeding (RB) for patients irradiated in the prostatic bed by 3-dimensional conformal radiation ...
Winkler Thomas W TW Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany, Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland, Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne 1010, Switzerland, Swiss Institute of Bioinformatics, Lausanne, Switzerland, Statistical Bioinformatics, Institute for Functional Genomics, University of Regensburg, Regensburg, Germany, Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, 6020 Innsbruck, Austria thomas.winkler@ukr.de - - 2014
The R package EasyStrata facilitates the evaluation and visualisation of stratified genome-wide association meta-analyses (GWAMAs) results. It provides (i) statistical methods to test and account for between-strata difference as a means to tackle gene-strata (GxS) interaction effects and (ii) extended graphical features tailored for stratified GWAMA results. The software provides ...
Chen Weisheng - - 2014
This paper addresses the problem of globally stable direct adaptive backstepping neural network (NN) tracking control design for a class of uncertain strict-feedback systems under the assumption that the accuracy of the ultimate tracking error is given a priori. In contrast to the classical adaptive backstepping NN control schemes, this ...
Meyer Matthew J MJ Graduate Program in Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry , London, Ontario , Canada - - 2014
Abstract Purpose: This systematic review summarizes the utility of variables available at acute discharge after stroke for predicting functional independence at discharge from inpatient rehabilitation. Methods: A systematic review of four electronic databases (Medline, EMBASE, PsycINFO and CINAHL) was conducted to identify studies reporting multivariable models predicting post-rehabilitation Barthel Index ...
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