Search Results
Results 401 - 450 of 2365
< 4 5 6 7 8 9 10 11 12 13 14 >
Bozkurt Hayriye H Department of Food Science and Technology, The University of Tennessee, 2600 River Drive, Knoxville, TN 37996-4591, - - 2014
Control of seafood-associated norovirus outbreaks has become an important priority for public health authorities. Due to the absence of human norovirus infectivity assays, cultivable surrogates such as feline calicivirus (FCV-F9) and murine norovirus (MNV-1) have been used to begin to understand their thermal inactivation behavior. In this study, the effect ...
Suo Chen - - 2013
RNA-sequencing technologies provide a powerful tool for expression analysis at gene and isoform level, but accurate estimation of isoform abundance is still a challenge. Standard assumption of uniform read intensity would yield biased estimates when the read intensity is in fact non-uniform. The problem is that, without strong assumptions, the ...
Bordner Andrew J - - 2013
Despite the importance of a thermodynamically stable structure with a conserved fold for protein function, almost all evolutionary models neglect site-site correlations that arise from physical interactions between neighboring amino acid sites. This is mainly due to the difficulty in formulating a computationally tractable model since rate matrices can no ...
Reutlinger Christoph C Institute for Surgical Technology and Biomechanics, University of Bern, Switzerland. Electronic address: - - 2013
Numerical models of the intervertebral disc, which address mechanical questions commonly make use of the difference in water content between annulus and nucleus, and thus fluid and solid parts are separated. Despite this simplification, models remain complex due to the anisotropy and nonlinearity of the annulus and regional variations of ...
Pavlov Michael Y - - 2013
Bacterial populations growing in a changing world must adjust their proteome composition in response to alterations in the environment. Rapid proteome responses to growth medium changes are expected to increase the average growth rate and fitness value of these populations. Little is known about the dynamics of proteome change, e.g., ...
Bourne Roger M - - 2013
To compare the theoretical information content of four popular models of diffusion-weighted signal attenuation. Four whole prostates were imaged fresh unfixed and fixed at 9.4T. Biexponential, kurtosis, stretched exponential, and monoexponential models were ranked using Akaike's Information Criterion (AIC) with validation by a leave-one-out test of model prediction error. For ...
Hindmarch C C T CC University of Bristol, The Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, Bristol, - - 2013
The supraoptic nucleus (SON) is part of the central osmotic circuitry that synthesises the hormone vasopressin (Avp) and transports it to terminals in the posterior lobe of the pituitary. Following osmotic stress such as dehydration, this tissue undergoes morphological, electrical and transcriptional changes to facilitate the appropriate regulation and release ...
Asano Yoshihide - - 2013
Systemic sclerosis (SSc) is a multisystem connective tissue disease characterized by three cardinal features: immunological abnormalities, vasculopathy, and fibrosis of skin and certain internal organs. Although several animal models recapitulating selected aspects of SSc have been reported, the absence of models fulfilling the full clinical picture of SSc has hindered ...
Hossain Ahmed - - 2013
Abstract MicroRNAs (miRNAs) are short non-coding RNAs that play critical roles in numerous cellular processes through post-transcriptional functions. The aberrant role of miRNAs has been reported in a number of diseases. A robust computational method is vital to discover novel miRNAs where level of noise varies dramatically across the different ...
Scully Robert R - - 2013
Abstract The pulmonary toxicity of airborne lunar dust was assessed in rats exposed by nose-only inhalation to 0, 2.1, 6.8, 20.8 and 60.6 mg/m3 of respirable size lunar dust. Rats were exposed for 6 h/d, 5 d/week, for 4 weeks (120 h). Biomarkers of toxicity were assessed in bronchial alveolar lavage fluid (BALF) collected ...
Lee Taewoo - - 2013
Purpose: Intensity-modulated radiation therapy (IMRT) treatment planning typically combines multiple criteria into a single objective function by taking a weighted sum. The authors propose a statistical model that predicts objective function weights from patient anatomy for prostate IMRT treatment planning. This study provides a proof of concept for geometry-driven weight ...
Motallebi Sadegh S Department of Computer Engineering, Sharif University of Technology, Tehran, - - 2013
Real networks exhibit nontrivial topological features, such as heavy-tailed degree distribution, high clustering, and small-worldness. Researchers have developed several generative models for synthesizing artificial networks that are structurally similar to real networks. An important research problem is to identify the generative model that best fits to a target network. In ...
Pandey Abhishek - - 2013
Various simple mathematical models have been used to investigate dengue transmission. Some of these models explicitly model the mosquito population, while others model the mosquitoes implicitly in the transmission term. We study the impact of modeling assumptions on the dynamics of dengue in Thailand by fitting dengue hemorrhagic fever (DHF) ...
Tung David D BioMed Valley Discoveries, Kansas City, - - 2013
Trilostane was identified in an in vivo screen of compounds in a lipopolysaccharide model of inflammation to support a repurposing effort. There is no previous documentation of any anti-inflammatory effects of trilostane. The aim of this study was to elucidate the novel pharmacologic activity of trilostane in a series of ...
Hébert-Dufresne Laurent L Département de Physique, de Génie Physique, et d'Optique, Université Laval, Québec (Québec), Canada G1V - - 2013
The k-core decomposition of a network has thus far mainly served as a powerful tool for the empirical study of complex networks. We now propose its explicit integration in a theoretical model. We introduce a hard-core random network (HRN) model that generates maximally random networks with arbitrary degree distribution and ...
Wang Chen-Pin CP Department of Epidemiology and Biostatistics, University of Texas Health Science Center, San Antonio TX, 78229, - - 2013
Wang and Ghosh (2011) proposed a Kullback-Leibler divergence (KLD) which is asymptotically equivalent to the KLD by Goutis and Robert (1998) when the reference model (in comparison with a competing fitted model) is correctly specified and when certain regularity conditions hold true. While properties of the KLD by Wang and ...
Baum-Snow Nathaniel N Brown University & - - 2013
Between 1979 and 2007 a strong positive monotonic relationship between wage inequality and city size has developed. This paper investigates the links between this emergent city size inequality premium and the contemporaneous nationwide increase in wage inequality. After controlling for the skill composition of the workforce across cities of different ...
Khataee H R - - 2013
Kinesin is a smart motor protein that steps processively forward and backward along microtubules (MTs). The mechanical kinetics of kinesin affecting its stepping behavior is not fully understood. Here, we propose a mathematical model to study the mechanical kinetics of forward and backward stepping of kinesin motor based on the ...
Khamiakova Tatsiana - - 2013
Benchmark datasets are important for the validation and optimization of the analysis routes. Lately, a new benchmark dataset, 'Platinum Spike', for the Affymetrix GeneChip experiments has been introduced. We performed a quality check of the Platinum Spike dataset by using probe-level linear mixed models. The results have shown that there ...
Turro Ernest - - 2013
Most methods for estimating differential expression from RNA-seq are based on statistics that compare normalised read counts between treatment classes. Unfortunately, reads are in general too short to be mapped unambiguously to features of interest, such as genes, isoforms or haplotype-specific isoforms. There are methods for estimating expression levels that ...
Stappaerts Jef - - 2013
Abstract 1. Although valuable in vitro models exist to study drug elimination from the systemic circulation, more integrated models may improve mechanistic insight in a biorelevant setting. 2. This study aimed to explore (1) intestinal and biliary excretion of the HIV protease inhibitor darunavir and its impact on systemic disposition and (2) ...
Asgaonkar Kalyani D KD AISSMS College of Pharmacy, Near R.T.O, Kennedy Road, Pune-411001, - - 2014
A quantitative structure-activity relationship model was developed on a series of compounds containing oxadiazole-ligated pyrrole pharmacophore to identify key structural fragments required for anti-tubercular activity. Two-dimensional (2D) and three-dimensional (3D) QSAR studies were performed using multiple linear regression (MLR) analysis and k-nearest neighbour molecular field analysis (kNN-MFA), respectively. The developed ...
Im Hansol - - 2013
This study assessed the dynamics of predation by Bdellovibrio bacteriovorus HD 100. Predation tests with two different bioluminescent strains of Escherichia coli, one expressing a heat-labile bacterial luciferase and the other a heat-stable form, showed near identical losses from both, indicating that protein expression and stability are not responsible for ...
Hashway S A - - 2013
Use of a levonorgestrel-releasing intrauterine system (LNG-IUS) in humans may alter vaginal microbial populations and susceptibility to pathogens. This study evaluated the time-dependent effects of an LNG-IUS on the vaginal microbiome of the baboon, a useful animal model for reproductive studies. Levonorgestrel-releasing intrauterine systems were inserted into three reproductively mature, ...
Pieper Ursula U Department of Bioengineering and Therapeutic Sciences, California Institute for Quantitative Biosciences, Byers Hall at Mission Bay, Office 503B, University of California at San Francisco, 1700 4th Street, San Francisco, CA 94158, USA, Department of Pharmaceutical Chemistry, California Institute for Quantitative Biosciences, Byers Hall at Mission Bay, Office 503B, University of California at San Francisco, 1700 4th Street, San Francisco, CA 94158, USA, Graduate Group in Biophysics, University of California at San Francisco, CA 94158, USA, Structural Bioinformatics Unit, Structural Biology and Chemistry department, Institut Pasteur, 25 rue du Docteur Roux, 75015 Paris, France, Université Paris Diderot-Paris 7, école doctorale iViv, Paris Rive Gauche, 5 rue Thomas Mann, 75013 Paris, France, Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA, Department of Molecular Biology, Skaggs Institute of Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA, Life Sciences Division, Department of Molecular Biology, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, - - 2014
ModBase (http://salilab.org/modbase) is a database of annotated comparative protein structure models. The models are calculated by ModPipe, an automated modeling pipeline that relies primarily on Modeller for fold assignment, sequence-structure alignment, model building and model assessment (http://salilab.org/modeller/). ModBase currently contains almost 30 million reliable models for domains in 4.7 million ...
Barman Rahul - - 2013
We used a land surface model constrained using data from flux tower sites, to analyze the biases in ecosystem energy and water fluxes arising due to the use of meteorological reanalysis datasets. Following site-level model calibration encompassing major vegetation types from the tropics to the northern high-latitudes, we repeated the ...
Hendrix Angelean O - - 2013
Mathematical models of the hypothalamus-pituitary-ovarian axis in women were first developed by Schlosser and Selgrade in 1999, with subsequent models of Harris-Clark et al. (Bull. Math. Biol. 65(1):157-173, 2003) and Pasteur and Selgrade (Understanding the dynamics of biological systems: lessons learned from integrative systems biology, Springer, London, pp. 38-58, 2011). These ...
Sen Sudip Kumar SK Department of Biotechnology, Gandhi Institute of Engineering and Technology, Gunupur, Rayagada 765 022, Odisha, - - 2013
In the present investigation, a number of experiments have been conducted to isolate microbial strains from Taptapani Hot Spring Odisha, India for bioremediation of cadmium and lead. The strains Stenotrophomonas maltophilia (SS1), Aeromonas veronii (SS2) and Bacillus barbaricus (SS3) have shown better adaptation to metal tolerance test, with different concentrations ...
Yuan Tingbi T State Key Lab of Power Systems, Department of Thermal Engineering, Tsinghua-BP Clean Energy Center, Tsinghua University, Beijing, China; Guodian Science and Technology Research Institute, Nanjing, - - 2014
A partial least squares (PLS) and wavelet transform hybrid model are proposed to analyze the carbon content of coal by using laser-induced breakdown spectroscopy (LIBS). The hybrid model is composed of two steps of wavelet analysis procedures, which include environmental denoising and background noise reduction, to pretreat the LIBS spectrum. ...
Charrier Guillaume - - 2013
In the literature, frost hardiness (FH) studies in trees have often been restricted to one organ (buds, leaves, needles or twigs). To extend our knowledge and gain a unified view, FH differences between organs and tissues or throughout the life of the tree have to be characterized in relation to ...
Yanes R - - 2013
The exchange bias effect in a compensated IrMn_{3}/Co(111) system is studied using multiscale modeling from ab initio to atomistic spin model calculations. We evaluate numerically the out-of-plane hysteresis loops of the bilayer for different thicknesses of the ferromagnetic layer. The results show the existence of a perpendicular exchange bias and an ...
Brzaković Branka - - 2013
The purpose of the study was to examine and describe adjunctive lamotrigine (LTG) pharmacokinetics in paediatric and young adult patients using a nonlinear mixed effects modelling (NONMEM) approach. The study included 53 patients (age range 3-35 years) who were concomitantly treated with carbamazepine (CBZ) and/or valproic acid (VPA). A total of ...
Jääskinen Väinö - - 2013
Abstract In many biological applications it is necessary to cluster DNA sequences into groups that represent underlying organismal units, such as named species or genera. In metagenomics this grouping needs typically to be achieved on the basis of relatively short sequences which contain different types of errors, making the use ...
Faltys G L - - 2013
Electronic feeding stations (EFS) were developed to automate data collection of individual animals housed in a group environment. In order for scientists to utilize EFS such as the Feed Intake Recording Equipment (FIRE; Osborne Industries Inc., Osborne, KS) in research, data recorded electronically cannot differ from data recorded on calibrated ...
Hammes Florian - - 2013
A process analytical method using reflectance infrared spectrometry was developed for the in-line monitoring of the amount of the active pharmaceutical ingredient (API) nicotine during a coating process for an oral thin film (OTF). In-line measurements were made using a reflectance infrared (RI) sensor positioned after the last drying zone ...
Skubák Pavol - - 2013
Determining new protein structures from X-ray diffraction data at low resolution or with a weak anomalous signal is a difficult and often an impossible task. Here we propose a multivariate algorithm that simultaneously combines the structure determination steps. In tests on over 140 real data sets from the protein data ...
Richardson Simon - - 2013
Fixed samples have been used extensively in diffusion MRI (dMRI) studies. However, fixation causes significant structural changes in tissue. The purpose of this study was to evaluate fixed white matter as a surrogate for viable white matter during development and validation of dMRI methods. dMRI data was acquired from fixed ...
Dobričić Vladimir - - 2013
In this paper, twenty-two 17β-carboxamide steroids were synthesized from five corticosteroids (hydrocortisone, prednisolone, methylprednisolone, dexamethasone and betamethasone) in two steps. The first step was periodic acid oxydation of these corticosteroids to corresponding cortienic acids and the second step was amidation of thus obtained cortienic acids with esterified L-amino acids. These ...
Brown Hamish E - - 2013
Background and AimsA model to predict anthesis time of a wheat plant from environmental and genetic information requires integration of current concepts in physiological and molecular biology. This paper describes the structure of an integrated model and quantifies its response mechanisms.MethodsLiterature was reviewed to formulate the components of the model. ...
Nims Robert J - - 2013
Large-sized cartilage constructs suffer from inhomogeneous extracellular matrix deposition due to insufficient nutrient availability. Computational models of nutrient consumption and tissue growth can be utilized as an efficient alternative to experimental trials to optimize the culture of large constructs; models require system-specific growth and consumption parameters. To inform models of ...
Ledbetter Michael P - - 2013
Evolution is a defining criterion of life and is central to understanding biological systems. However, the timescale of evolutionary shifts in phenotype limits most classroom evolution experiments to simple probability simulations. In vitro directed evolution (IVDE) frequently serves as a model system for the study of Darwinian evolution but produces ...
Ozcan Ozer - - 2013
To understand the effect of the long intracellular loop 3 (ICL3) on the intrinsic dynamics of human beta2-adrenergic receptor, molecular dynamics (MD) simulations were performed on two different models, both of which were based on the inactive crystal structure in complex with carazolol (after removal of carazolol and T4-lysozyme). In ...
Sharifi Mohsen - - 2013
Biliary excretion is one of the main elimination pathways for drugs and/or their metabolites. Therefore, an insight into the structural profile of cholephilic compounds through accurate modelling of the biliary excretion is important for the estimation of clinical pharmacokinetics in early stages of drug discovery. The aim of this study ...
Abrams Peter A - - 2013
How will evolution or other forms of adaptive change alter the response of a consumer species' population density to environmentally driven changes in population growth parameters? This question is addressed by analyzing some simple consumer-resource models to separate the ecological and evolutionary components of the population's response. Ecological responses are ...
Hanamoto Seiya - - 2013
Existing stochastic models for predicting concentrations of down-the-drain chemicals in aquatic environments do not account for the diurnal variation of direct photolysis by sunlight, despite its being an important factor in natural attenuation. To overcome this limitation, we developed a stochastic model incorporating temporal variations in direct photolysis. To verify ...
Lang Nadine R - - 2013
The pore size of biopolymer networks governs their mechanical properties and strongly impacts the behavior of embedded cells. Confocal reflection microscopy and second harmonic generation microscopy are widely used to image biopolymer networks; however, both techniques fail to resolve vertically oriented fibers. Here, we describe how such directionally biased data ...
Chen Yu - - 2013
In this paper, a new linear dimension reduction method called supervised orthogonal discriminant subspace projection (SODSP) is proposed, which addresses high-dimensionality of data and the small sample size problem. More specifically, given a set of data points in the ambient space, a novel weight matrix that describes the relationship between ...
Barker David H - - 2013
To introduce and illustrate recent advances in statistical approaches to simultaneous modeling of multiple change processes. Provide a general overview of how to use structural equations to simultaneously model multiple change processes and illustrate the use of a theoretical model of change to guide selection of an appropriate specification from ...
Blanco Celia - - 2013
Simulations of a chemical kinetics model, based on the free-energy relationships of classical primary nucleation theory, show that the deracemization phenomenon in systems of achiral or fast racemizing compounds yielding enantiopure crystals as the more stable solid phase is a true spontaneous mirror symmetry breaking process (SMSB). That is, the ...
Kelly Leo P LP Department of Neurosurgery, Rush University, Chicago, Illinois, USA; Department of Pharmacology, The Graduate College, Rush University, Chicago, Illinois, - - 2013
Parkinson's disease (PD) is a multifocal degenerative disorder for which there is no cure. The majority of cases are sporadic with unknown etiology. Recent data indicate that untreated patients with de novo PD have increased colonic permeability and that both de novo and premotor patients have pathological expression of α-synuclein ...
< 4 5 6 7 8 9 10 11 12 13 14 >