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Monzo Carlos C 0000-0003-3883-3588 Computer Science, Multimedia and Telecommunication Studies, Universitat Oberta de Catalunya (UOC), Rambla del Poblenou 156, 08018 Barcelona, - - 2014
This paper presents the perceptual experiments that were carried out in order to validate the methodology of transforming expressive speech styles using voice quality (VoQ) parameters modelling, along with the well-known prosody (F 0, duration, and energy), from a neutral style into a number of expressive ones. The main goal ...
Rudolph-Lilith Michelle M Unité de Neurosciences, Information et Complexité, CNRS, 1 Avenue de la Terrasse, 91198 Gif-sur-Yvette, - - 2014
We introduce an analytic model for directed Watts-Strogatz small-world graphs and deduce an algebraic expression of its defining adjacency matrix. The latter is then used to calculate the small-world digraph's asymmetry index and clustering coefficient in an analytically exact fashion, valid nonasymptotically for all graph sizes. The proposed approach is ...
Monfardini Elisabetta E INSERM, U1028, Lyon Neuroscience Research Center, ImpAct Team, Lyon, France ; CNRS, UMR5292, Lyon Neuroscience Research Center, ImpAct Team, Lyon, France ; University Lyon, Lyon, France ; Institut de Médecine Environnementale, Paris, - - 2014
Monkeys readily learn to discriminate between rewarded and unrewarded items or actions by observing their conspecifics. However, they do not systematically learn from humans. Understanding what makes human-to-monkey transmission of knowledge work or fail could help identify mediators and moderators of social learning that operate regardless of language or culture, ...
Song Minryung R MR Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, South - - 2014
Because most rewarding events are probabilistic and changing, the extinction of probabilistic rewards is important for survival. It has been proposed that the extinction of probabilistic rewards depends on arousal and the amount of learning of reward values. Midbrain dopamine neurons were suggested to play a role in both arousal ...
Kalinowska Barbara B Department of Bioinformatics and Telemedicine, Medical College, Jagiellonian University, Krakow, Poland; Faculty of Physics, Astronomy and Applied Computer Science - Jagiellonian University, Krakow, - - 2014
This work discusses the role of unstructured polypeptide chain fragments in shaping the protein's hydrophobic core. Based on the "fuzzy oil drop" model, which assumes an idealized distribution of hydrophobicity density described by the 3D Gaussian, we can determine which fragments make up the core and pinpoint residues whose location ...
Schermelleh-Engel Karin K Department of Psychology, Goethe University Frankfurt, - - 2014
Evaluating model fit in nonlinear multilevel structural equation models (MSEM) presents a challenge as no adequate test statistic is available. Nevertheless, using a product indicator approach a likelihood ratio test for linear models is provided which may also be useful for nonlinear MSEM. The main problem with nonlinear models is ...
Liu Yang Y 0000-0002-1187-6388 School of Transportation Science and Engineering, Harbin Institute of Technology, Harbin 150090, China ; Postdoctoral Station of Civil Engineering, Harbin Institute of Technology, Harbin 150090, - - 2014
Updating the structural model of complex structures is time-consuming due to the large size of the finite element model (FEM). Using conventional methods for these cases is computationally expensive or even impossible. A two-level method, which combined the Kriging predictor and the component mode synthesis (CMS) technique, was proposed to ...
Thomsen Kim K Department of Clinical Microbiology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, - - 2014
Medical biofilms have attracted substantial attention especially in the past decade. Animal models are contributing significantly to understand the pathogenesis of medical biofilms. In addition, animal models are an essential tool in testing the hypothesis generated from clinical observations in patients and preclinical testing of agents showing in vitro antibiofilm ...
Ericsson Aaron C AC Mutant Mouse Regional Resource Center (MMRRC), Rat Resource and Research Center (RRRC), Department of Veterinary Pathobiology, University of Missouri, Columbia, Missouri, USA. - - 2014
Segmented filamentous bacteria (SFB) are commensal bacteria that were first identified in the ilea of mice and rats. Morphologically similar bacteria occur in a broad range of host species, but all strains have been refractory to in vitro culture thus far. Although SFB were once considered innocuous members of the ...
Aguilar Alex A Department of Animal Biology and Biodiversity Research Institute (IrBio), Faculty of Biology, University of Barcelona, Barcelona, - - 2014
The finding that tissue δ15N values increase with protein catabolism has led researchers to apply this value to gauge nutritive condition in vertebrates. However, its application to marine mammals has in most occasions failed. We investigated the relationship between δ15N values and the fattening/fasting cycle in a model species, the ...
Polade Suraj D SD Climate, Atmospheric Science and Physical Oceanography (CASPO), Scripps Institution of Oceanography, La Jolla, CA, - - 2014
Future changes in the number of dry days per year can either reinforce or counteract projected increases in daily precipitation intensity as the climate warms. We analyze climate model projected changes in the number of dry days using 28 coupled global climate models from the Coupled Model Intercomparison Project, version ...
van Hasselt J G Coen JG Department of Clinical Pharmacology, Netherlands Cancer Institute, Plesmanlaan 121, P.O. Box 1066 CX, Amsterdam, The Netherlands ; Department of Pharmacy & Pharmacology, Netherlands Cancer Institute/Slotervaart Hospital, Louwesweg 6, P.O. Box 90440, 1006 BK Amsterdam, The - - 2014
This work describes a first population pharmacokinetic (PK) model for free and total cefazolin during pregnancy, which can be used for dose regimen optimization. Secondly, analysis of PK studies in pregnant patients is challenging due to study design limitations. We therefore developed a semiphysiological modeling approach, which leveraged gestation-induced changes ...
Boughammoura Sondès S Faculty of Sciences of Monastir, UR Electrolytes, University of Monastir, 5000 Monastir, - - 2014
We have proved in details that the dielectric friction remains the principal frictional effect for a stretched polyion modeled as a chain of charged spheres, whereas, in the case of Manning's model (infinite thread with a continuous distribution of charge), this friction effect is nonexistent. According to this chain model, ...
Jordán Cristina C Instituto de Matemáticas Multidisciplinar, Universitat Politècnica de València, Camino de Vera s/n, 46022 Valencia, - - 2014
An n × n matrix is called an N 0-matrix if all its specified principal minors are nonpositive. In the context of partial matrices, a partial matrix is called a partial N 0-matrix if all its specified principal minors are nonpositive. In this paper we characterize the existence of an ...
Badhan Raj K Singh RK Manchester Pharmacy School, the University of Manchester, Oxford Road, Manchester, M13 9PT, UK. - - 2014
Central nervous system (CNS) drug disposition is dictated by a drug's physicochemical properties and its ability to permeate physiological barriers. The blood-brain barrier (BBB), blood-cerebrospinal fluid barrier and centrally located drug transporter proteins influence drug disposition within the central nervous system. Attainment of adequate brain-to-plasma and cerebrospinal fluid-to-plasma partitioning is ...
Peterlík Igor I Institut Hospitalo-Universitaire, Strasbourg, - - 2014
Accurate biomechanical modeling of liver is of paramount interest in pre-operative planning or computer-aided per-operative guidance. Since the liver is an organ composed of three different components (parenchyma, vascularization and Glisson's capsule), an efficient and realistic simulation of its behaviour is a challenging task. In this paper we propose a ...
Song Yunke Y Biomedical Engineering Department, Johns Hopkins University, Baltimore, Maryland, United States of - - 2014
Adapter ligation is a critical first step in many microRNA analysis methods including microarray, qPCR, and sequencing. Previous studies have shown that ligation bias can have dramatic effects on both the fidelity of expression profiles and reproducibility across samples. We have developed a method for high efficiency and low bias ...
Puyol D D Department of Chemical and Environmental Engineering, The University of Arizona, Tucson, AZ 85721, USA E-mail: danielpuyol@email.arizona.edu; - - 2014
Anaerobic ammonium oxidation (anammox) is a recently discovered microbial process commonly applied to treat ammonium pollution in effluents with low organic carbon content. Modeling anammox processes is important for simulating and controlling full-scale plants. In this study, the anammox process was simulated using three models, and substrate and growth parameters ...
Franks Becca B Department of Psychology, Columbia University, New York, New York, United States of - - 2014
As animal personality research becomes more central to the study of animal behavior, there is increasing need for theoretical frameworks addressing its causes and consequences. We propose that regulatory focus theory (RFT) could serve as one such framework while also providing insights into how animal personality relates to welfare. RFT ...
Jaber Khalid Mohammad KM Faculty of Science and Information Technology, Al-Zaytoonah University of Jordan, Amman, - - 2014
In recent times, the size of biological databases has increased significantly, with the continuous growth in the number of users and rate of queries; such that some databases have reached the terabyte size. There is therefore, the increasing need to access databases at the fastest rates possible. In this paper, ...
Nakada Yohei - - 2014
Online Bayesian learning has been successfully applied to online learning for multilayer perceptrons and radial basis functions. In online Bayesian learning, typically, the conventional transition model has been used. Although the conventional transition model is based on the squared norm of the difference between the current parameter vector and the ...
Huanhuan Chen - - 2014
The emergence of large sensor networks has facilitated the collection of large amounts of real-time data to monitor and control complex engineering systems. However, in many cases the collected data may be incomplete or inconsistent, while the underlying environment may be time-varying or unformulated. In this paper, we develop an ...
Gentile Lori F LF Departments of Surgery, University of Florida College of Medicine, Gainesville, Florida, United States of - - 2014
Animal models for the study of sepsis are being increasingly scrutinized, despite their essential role for early translational research. In particular, recent studies have suggested that at the level of the leukocyte transcriptome, murine models of burns, trauma and endotoxemia markedly differ from their human equivalents, and are only weakly ...
Grupe Gisela - - 2014
The application of mixing models for the sourcing of dietary end members, which mix into consumer collagen delta13C and delta15N isotopic ratios, has clear benefits for understanding human palaeodiet and human and vertebrate palaeoecology. This is because traditional visual or conventional statistical interpretations of bivariate plots may be erroneous or ...
Matthews Brett A BA School of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA 30332, - - 2014
This paper details a novel probabilistic method for automatic neural spike sorting which uses stochastic point process models of neural spike trains and parameterized action potential waveforms. A novel likelihood model for observed firing times as the aggregation of hidden neural spike trains is derived, as well as an iterative ...
Ebrahimi Mansour M Department of Biology, School of Basic Sciences, University of Qom, Qom, - - 2014
The evolution of the influenza A virus to increase its host range is a major concern worldwide. Molecular mechanisms of increasing host range are largely unknown. Influenza surface proteins play determining roles in reorganization of host-sialic acid receptors and host range. In an attempt to uncover the physic-chemical attributes which ...
do Nascimento N F F NF Laboratório de Análises de Progênies, Departamento de Fitotecnia, Pós-Graduação em Genética e Melhoramento, Centro de Ciências Agrárias, Universidade Federal de Viçosa, Viçosa, Minas Gerais, - - 2014
The objective of this study was to determine the effects of the general and specific combining abilities (GCA and SCA, respectively) of 15 characteristics and to evaluate the most promising crosses and the reciprocal effect between the hybrids of six parents of the Capsicum annuum species. Six parents, belonging to ...
Nakajima Natsu N Bioinformatics Center, Institute for Chemical Research, Kyoto University, Gokasho, Uji, Kyoto 611-0011, - - 2014
We tackle the problem of completing and inferring genetic networks under stationary conditions from static data, where network completion is to make the minimum amount of modifications to an initial network so that the completed network is most consistent with the expression data in which addition of edges and deletion ...
Hierholtzer A A Urban Water Technology Centre, School of Science, Engineering and Technology, University of Abertay Dundee, Bell Street, Dundee DD1 1HG, Scotland, UK E-mail: - - 2014
Some of the key factors affecting the adaptation of anaerobic digestion processes to increasing levels of salinity were determined in batch tests using brown seaweed as a feedstock. It was found that cultures seeded with non-saline anaerobic inoculum required an adaptation period of up to two months to reach the ...
Davoodi-Bojd Esmaeil E School of Electrical and Computer Engineering, University of Tehran, Tehran, Iran; Department of Neurology, Henry Ford Health System, Detroit, Michigan, United States of - - 2014
Substantial effort is being expended on using micro-structural modeling of the white matter, with the goal of relating diffusion weighted magnetic resonance imaging (DWMRI) to the underlying structure of the tissue, such as axonal density. However, one of the important parameters affecting diffusion is the water exchange rate between the ...
Li Borui B Department of Automation, Tsinghua University, Beijing 100084, China. - - 2014
Traditional object tracking technology usually regards the target as a point source object. However, this approximation is no longer appropriate for tracking extended objects such as large targets and closely spaced group objects. Bayesian extended object tracking (EOT) using a random symmetrical positive definite (SPD) matrix is a very effective ...
Römer Michael M Center of Bioinformatics Tuebingen (ZBIT), University of Tuebingen, Tübingen, - - 2014
In the area of omics profiling in toxicology, i.e. toxicogenomics, characteristic molecular profiles have previously been incorporated into prediction models for early assessment of a carcinogenic potential and mechanism-based classification of compounds. Traditionally, the biomarker signatures used for model construction were derived from individual high-throughput techniques, such as microarrays designed ...
Du Qiang Q Department of Hepatobiliary Surgery, The Affiliated Union Hospital of Fujian Medical University, Fuzhou, China E-mail : ylchen@medmail.com.cn, - - 2014
Background: Gallbladder carcinoma (GBC) is the most common carcinoma of the biliary system. Among its research models, orthotopic xenograft models, important research tools, have been rarely reported in the literature however. Aim: To explore establishment of an orthotopic xenograft model and to evaluate the advantage and disadvantage as compared with ...
Jackson Alice F AF Laboratory for the Neurodevelopment of Reading and Language, Department of Human Development and Quantitative Methodology, University of Maryland College Park, MD, USA ; Program for Neuroscience and Cognitive Science, University of Maryland College Park, MD, - - 2014
The GOLD model (Graph Of Language Distribution) is a network model constructed based on co-occurrence in a large corpus of natural language that may be used to explore what information may be present in a graph-structured model of language, and what information may be extracted through theoretically-driven algorithms as well ...
Keeping Derek D Department of Renewable Resources, University of Alberta, Edmonton, Alberta, - - 2014
Counting animals to estimate their population sizes is often essential for their management and conservation. Since practitioners frequently rely on indirect observations of animals, it is important to better understand the relationship between such indirect indices and animal abundance. The Formozov-Malyshev-Pereleshin (FMP) formula provides a theoretical foundation for understanding the ...
Gunawardena Jeremy J Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, Boston, USA. - - 2014
: In this essay I will sketch some ideas for how to think about models in biology. I will begin by trying to dispel the myth that quantitative modeling is somehow foreign to biology. I will then point out the distinction between forward and reverse modeling and focus thereafter on ...
Diekman Casey O CO Department of Mathematical Sciences, New Jersey Institute of Technology, Newark, NJ, 07102, - - 2014
Hugh Wilson has proposed a class of models that treat higher-level decision making as a competition between patterns coded as levels of a set of attributes in an appropriately defined network (Cortical Mechanisms of Vision, pp. 399-417, 2009; The Constitution of Visual Consciousness: Lessons from Binocular Rivalry, pp. 281-304, 2013). ...
Zhang Pu P 0000-0003-4347-0224 Department of Mathematics, Mudanjiang Normal University, Mudanjiang 157011, - - 2014
Let T be a singular integral operator with its kernel satisfying |K(x - y) - ∑ k=1 (ℓ) ‍B k (x)ϕ k (y)| ≤ C | y| (γ) /|x - y| (n+γ) , |x | > 2 | y | > 0, where B k and ϕ k   (k = ...
Baumann Jenny J IUF-Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany; Both authors contributed equally to this - - 2014
The developing nervous system is highly vulnerable to the adverse effects of chemical agents. Currently, there is an increasing need for testing and regulating chemical compounds in general use and, due to the lack of available data, to identify those which are developmental neurotoxicants. In this context, alternative testing strategies ...
Picard Nicolas N UPR Biens et services des écosystèmes forestiers tropicaux (BSEF), Centre de coopération internationale en recherche agronomique pour le développement (CIRAD), Montpellier, - - 2014
Matrix population models are widely used to study population dynamics but have been criticized because their outputs are sensitive to the dimension of the matrix (or, equivalently, to the class width). This sensitivity is concerning for the population growth rate ([Formula: see text]) because this is an intrinsic characteristic of ...
Sharp Thomas T School of Computer Science, The University of Manchester Manchester, UK ; Laboratory for Neural Circuit Theory, RIKEN Brain Science Institute, Wakoshi Saitama, - - 2014
Simulations of neural circuits are bounded in scale and speed by available computing resources, and particularly by the differences in parallelism and communication patterns between the brain and high-performance computers. SpiNNaker is a computer architecture designed to address this problem by emulating the structure and function of neural tissue, using ...
Chen Zeqiang Z Institute of Space and Earth Information Science, The Chinese University of Hong Kong, Shatin, Hong Kong ; Collaborative Innovation Center for Geospatial Information Technology, Wuhan University, Wuhan 430079, China ; Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen 518057, - - 2014
Sharing and integrating Remote Sensing (RS) and Geographic Information System/Science (GIS) models are critical for developing practical application systems. Facilitating model sharing and model integration is a problem for model publishers and model users, respectively. To address this problem, a framework based on a Web service for sharing and integrating ...
Ju Jingjuan J Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China. - - 2014
In fresh waters cyanobacterial blooms can produce a variety of toxins, such as microcystin variants (MCs) and anatoxin-a (ANA). ANA is a well-known neurotoxin, whereas MCs are hepatotoxic and, to a lesser degree, also neurotoxic. Neurotoxicity applies especially to invertebrates lacking livers. Current standardized neurotoxicity screening methods use rats or ...
Talluri Rajesh R The University of Texas MD Anderson Cancer Center, Houston, TX, - - 2014
We propose Bayesian methods for Gaussian graphical models that lead to sparse and adaptively shrunk estimators of the precision (inverse covariance) matrix. Our methods are based on lasso-type regularization priors leading to parsimonious parameterization of the precision matrix, which is essential in several applications involving learning relationships among the variables. ...
Zhang Xiaohang X School of Economics and Management, Beijing University of Posts and Telecommunications, Beijing, - - 2014
A complex network is a useful tool for representing and analyzing complex systems, such as the world-wide web and transportation systems. However, the growing size of complex networks is becoming an obstacle to the understanding of the topological structure and their characteristics. In this study, a globally and locally adaptive ...
Nielsen J Rasmus JR Technical University of Denmark, National Institute of Aquatic Resources (DTU AQUA), Charlottenlund, - - 2014
Trawl survey data with high spatial and seasonal coverage were analysed using a variant of the Log Gaussian Cox Process (LGCP) statistical model to estimate unbiased relative fish densities. The model estimates correlations between observations according to time, space, and fish size and includes zero observations and over-dispersion. The model ...
Farasat Iman I Department of Chemical Engineering, Pennsylvania State University, University Park, PA, - - 2014
Developing predictive models of multi-protein genetic systems to understand and optimize their behavior remains a combinatorial challenge, particularly when measurement throughput is limited. We developed a computational approach to build predictive models and identify optimal sequences and expression levels, while circumventing combinatorial explosion. Maximally informative genetic system variants were first ...
Gong Jing J Cancer Research Center, School of Medicine, Shandong University, Jinan, 250012, - - 2014
Toll-like receptors (TLRs) recognize invasion of microbial pathogens and initiate innate immune responses that are essential for inhibiting pathogen dissemination and for the development of acquired immunity. To understand how these receptors work, it is crucial to investigate them from a structural perspective. High-throughput genome sequencing projects have led to ...
Ryu Ehri E Department of Psychology, Boston College Chestnut Hill, MA, - - 2014
Assessing goodness of model fit is one of the key questions in structural equation modeling (SEM). Goodness of fit is the extent to which the hypothesized model reproduces the multivariate structure underlying the set of variables. During the earlier development of multilevel structural equation models, the "standard" approach was to ...
Zoratto Francesca F 0000-0002-3626-8928 Section of Behavioural Neuroscience, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy ; Bambino Gesù Children's Hospital IRCCS, Rome, - - 2014
Interest is rising for animal modeling of pathological gambling. Using the operant probabilistic-delivery task (PDT), gambling proneness can be evaluated in laboratory animals. Drawing a comparison with rats, this study evaluated the common marmoset (Callithrix jacchus) using a PDT. By nose- or hand-poking, subjects learnt to prefer a large (LLL, ...
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