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Zhang Xiaohang X School of Economics and Management, Beijing University of Posts and Telecommunications, Beijing, - - 2014
A complex network is a useful tool for representing and analyzing complex systems, such as the world-wide web and transportation systems. However, the growing size of complex networks is becoming an obstacle to the understanding of the topological structure and their characteristics. In this study, a globally and locally adaptive ...
Nielsen J Rasmus JR Technical University of Denmark, National Institute of Aquatic Resources (DTU AQUA), Charlottenlund, - - 2014
Trawl survey data with high spatial and seasonal coverage were analysed using a variant of the Log Gaussian Cox Process (LGCP) statistical model to estimate unbiased relative fish densities. The model estimates correlations between observations according to time, space, and fish size and includes zero observations and over-dispersion. The model ...
Farasat Iman I Department of Chemical Engineering, Pennsylvania State University, University Park, PA, - - 2014
Developing predictive models of multi-protein genetic systems to understand and optimize their behavior remains a combinatorial challenge, particularly when measurement throughput is limited. We developed a computational approach to build predictive models and identify optimal sequences and expression levels, while circumventing combinatorial explosion. Maximally informative genetic system variants were first ...
Gong Jing J Cancer Research Center, School of Medicine, Shandong University, Jinan, 250012, - - 2014
Toll-like receptors (TLRs) recognize invasion of microbial pathogens and initiate innate immune responses that are essential for inhibiting pathogen dissemination and for the development of acquired immunity. To understand how these receptors work, it is crucial to investigate them from a structural perspective. High-throughput genome sequencing projects have led to ...
Ryu Ehri E Department of Psychology, Boston College Chestnut Hill, MA, - - 2014
Assessing goodness of model fit is one of the key questions in structural equation modeling (SEM). Goodness of fit is the extent to which the hypothesized model reproduces the multivariate structure underlying the set of variables. During the earlier development of multilevel structural equation models, the "standard" approach was to ...
Zoratto Francesca F 0000-0002-3626-8928 Section of Behavioural Neuroscience, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy ; Bambino Gesù Children's Hospital IRCCS, Rome, - - 2014
Interest is rising for animal modeling of pathological gambling. Using the operant probabilistic-delivery task (PDT), gambling proneness can be evaluated in laboratory animals. Drawing a comparison with rats, this study evaluated the common marmoset (Callithrix jacchus) using a PDT. By nose- or hand-poking, subjects learnt to prefer a large (LLL, ...
Moseby Katherine E KE The University of Adelaide, North Terrace, Adelaide, Australia; Arid Recovery, Roxby Downs, - - 2014
Reintroduction programs for threatened species often include elaborate release strategies designed to improve success, but their advantages are rarely tested scientifically. We used a set of four experiments to demonstrate that the influence of release strategies on short-term reintroduction outcomes is related to both intrinsic and extrinsic factors. We compared ...
Zhang Jun J Department of Chemistry, Rutgers University, Camden, New Jersey, United States of America; The Rutgers Center for Computational and Integrative Biology, Camden, New Jersey, United States of - - 2014
In vitro bioassays have been developed and are currently being evaluated as potential alternatives to traditional animal toxicity models. Already, the progress of high throughput screening techniques has resulted in an enormous amount of publicly available bioassay data having been generated for a large collection of compounds. When a compound ...
Li Yuqin Y College of Pharmacy, Taishan Medical University, Taian, Shandong 271016, - - 2014
Quantitative structure-activity relationships (QSAR) were developed to predict the inhibition ratio of pyrrolidine derivatives on matrix metalloproteinase via heuristic method (HM) and gene expression programming (GEP). The descriptors of 33 pyrrolidine derivatives were calculated by the software CODESSA, which can calculate quantum chemical, topological, geometrical, constitutional, and electrostatic descriptors. HM ...
Di Marco Fabiana F Department of Biotechnology and Applied Clinical Science, University of L'Aquila, L'Aquila, - - 2014
The central nervous system undergoing degeneration can be stabilized, and in some models can be restored to function, by neuroprotective treatments. Photobiomodulation (PBM) and dietary saffron are distinctive as neuroprotectants in that they upregulate protective mechanisms, without causing measurable tissue damage. This study reports a first attempt to combine the ...
Weir Scott M SM The Institute of Environmental and Human Health, Department of Environmental Toxicology, Texas Tech University, Lubbock, Texas, United States of - - 2014
Despite widespread recognition of significant data deficiencies, reptiles remain a relatively understudied taxon in ecotoxicology. To conduct ecological risk assessments on reptiles frequently requires using surrogate taxa such as birds, but recent research suggests that reptiles have significantly different exposure profiles and toxicant sensitivity. We exposed western fence lizards, Sceloporus ...
Liu Enqiang E University of Science and Technology Beijing, Beijing 100083, - - 2014
The contents access and sharing in multimedia social networks (MSNs) mainly rely on access control models and mechanisms. Simple adoptions of security policies in the traditional access control model cannot effectively establish a trust relationship among parties. This paper proposed a novel two-party trust architecture (TPTA) to apply in a ...
Tedford Stephanie E SE Department of Pharmacology, Center for Compulsive Behavior and Addiction, Rush University Medical Center Chicago, IL, USA ; Department of Pharmacology, Rush University Medical Center Chicago, IL, - - 2014
Pathological gambling is one manifestation of impulse control disorders. The biological underpinnings of these disorders remain elusive and treatment is far from ideal. Animal models of impulse control disorders are a critical research tool for understanding this condition and for medication development. Modeling such complex behaviors is daunting, but by ...
Banon-Maneus E E Comprehensive Pneumology Center, University Hospital Großhadern, Ludwig-Maximilians-University, 81337 Munich, Germany ; Fundació Clínic, Laboratori Experimental de Nefrologia i Transplantament (LENIT), CELLEX 2B, C/Casanova 143, 08036 Barcelona, - - 2014
Progression of chronic kidney disease (CKD) is characterized by deposition of extracellular matrix. This is an irreversible process that leads to tubulointerstitial fibrosis and finally loss of kidney function. Wnt/ β -catenin pathway was reported to be aberrantly activated in the progressive damage associated with chronic organ failure. Extensive renal ...
Rocha Bruno Alves BA Departamento de Química, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, 14040-901 Ribeirão Preto, SP, - - 2014
Monensin A is a commercially important natural product isolated from Streptomyces cinnamonensins that is primarily employed to treat coccidiosis. Monensin A selectively complexes and transports sodium cations across lipid membranes and displays a variety of biological properties. In this study, we evaluated the Jacobsen catalyst as a cytochrome P450 biomimetic ...
Leil T A TA Exploratory Clinical & Translational Research, Bristol-Myers Squibb Company, Lawrenceville, New Jersey, - - 2014
A Bayesian mechanism-based pharmacokinetic/pharmacodynamic model of cytochrome P450 3A4 (CYP3A4) activity was developed based on a clinical study of the effects of ketoconazole and rifampin on midazolam exposure and plasma 4β-hydroxycholesterol (4βHC) concentrations. Simulations from the model demonstrated that the dynamic range of 4βHC as a biomarker of CYP3A4 induction ...
Langmead Christopher James CJ Carnegie Mellon University, Pittsburgh, PA, USA, - - 2014
Atomistic simulations of the conformational dynamics of proteins can be performed using either Molecular Dynamics or Monte Carlo procedures. The ensembles of three-dimensional structures produced during simulation can be analyzed in a number of ways to elucidate the thermodynamic and kinetic properties of the system. The goal of this chapter ...
Rassoli Aisa A Biological Fluid Mechanics Research Laboratory, Biomedical Engineering Faculty, Amirkabir University of Technology (Tehran Polytechnic), Tehran, - - 2014
Purpose: The Mechanical properties of the ureteral wall may be altered by certain diseases&nbsp;such as megaureter. Ureter compliance and wall tension alterations can occur, leading to&nbsp;some abnormalities such as reflex mechanisms. Familiarizing with the mechanical properties&nbsp;of the ureter can help us advance in the understanding of urinary tract diseases. Materials ...
Yan Chang-An CA State Key Laboratory of Pollution Control & Resource Reuse, School of the Environment, Nanjing University, Nanjing 210093, China ; Key Laboratory of Digital Earth Science, Institute of Remote Sensing and Digital Earth (RADI), Chinese Academy of Sciences (CAS), Beijing 100094, - - 2014
A watershed hydrological model, hydrological simulation program-Fortran (HSPF), was applied to simulate the spatial and temporal variation of hydrological processes in the Jiaoyi watershed of Huaihe River Basin, the heaviest shortage of water resources and polluted area in China. The model was calibrated using the years 2001-2004 and validated with ...
Smith Aaron D AD Department of Biological Sciences, Northern Arizona University, PO Box 5640, Flagstaff, AZ, 86011-5640, - - 2014
Darkling beetle larvae (Coleoptera, Tenebrionidae) are collectively referred to as false wireworms. Larvae from several species in the genus Eleodes are considered to be agricultural pests, though relatively little work has been done to associate larvae with adults of the same species and only a handful of species have been ...
Salewski Volker V Michael-Otto-Institut im NABU, Bergenhusen, - - 2014
Changes in morphology have been postulated as one of the responses of animals to global warming, with increasing ambient temperatures leading to decreasing body size. However, the results of previous studies are inconsistent. Problems related to the analyses of trends in body size may be related to the short-term nature ...
Dally Simon S Institute for Laboratory and Transfusion Medicine, Heart and Diabetes Center North Rhine-Westphalia, Bad Oeynhausen, Germany; Department of Molecular Biotechnology, Fraunhofer Institute for Interfacial Engineering and Biotechnology, Stuttgart, - - 2014
Since its development, microarray technology has evolved to a standard method in the biotechnological and medical field with a broad range of applications. Nevertheless, the underlying mechanism of the hybridization process of PCR-products to microarray capture probes is still not completely understood, and several observed phenomena cannot be explained with ...
Heredia Ortiz Roberto R Département de santé environnementale et santé au travail, Chaire d'analyse et de gestion des risques toxicologiques and Institut de recherche en santé publique de l'Université de Montréal, Université de Montréal, Montréal, Québec, - - 2014
Biomathematical modeling has become an important tool to assess xenobiotic exposure in humans. In the present study, we have used a human physiologically-based pharmacokinetic (PBPK) model and an simple compartmental toxicokinetic model of benzo(a)pyrene (BaP) kinetics and its 3-hydroxybenzo(a)pyrene (3-OHBaP) metabolite to reproduce the time-course of this biomarker of exposure ...
Fedorova Elena V EV Saint-Petersburg State Chemical Pharmaceutical Academy, Ministry of Healthcare and Social Development of Russian Federation, Saint-Petersburg, Russian - - 2014
Based on the data about structure and antidiabetic activity of twenty seven vanadium and zinc coordination complexes collected from literature we developed QSAR models using the GUSAR program. These QSAR models were applied to 10 novel vanadium coordination complexes designed in silico in order to predict their hypoglycemic action. The ...
Gusenleitner Daniel D Bioinformatics Program, Boston University, Boston, Massachusetts, United States of America; Department of Computational Biomedicine, Boston University Medical Campus, Boston, Massachusetts, United States of - - 2014
Despite an overall decrease in incidence of and mortality from cancer, about 40% of Americans will be diagnosed with the disease in their lifetime, and around 20% will die of it. Current approaches to test carcinogenic chemicals adopt the 2-year rodent bioassay, which is costly and time-consuming. As a result, ...
Matsuda Eiko E Department of Arts and Sciences, The University of Tokyo, Tokyo, Japan; School of Informatics and Engineering, University of Sussex, Brighton, United Kingdom; Japan Society for the Promotion of Science, Tokyo, - - 2014
Vicarious trial-and-error (VTE) is a behavior observed in rat experiments that seems to suggest self-conflict. This behavior is seen mainly when the rats are uncertain about making a decision. The presence of VTE is regarded as an indicator of a deliberative decision-making process, that is, searching, predicting, and evaluating outcomes. ...
Jones Daniel O B DO National Oceanography Centre, University of Southampton Waterfront Campus, European Way, Southampton, SO14 3ZH, - - 2013
Seafloor organisms are vital for healthy marine ecosystems, contributing to elemental cycling, benthic remineralization, and ultimately sequestration of carbon. Deep-sea life is primarily reliant on the export flux of particulate organic carbon from the surface ocean for food, but most ocean biogeochemistry models predict global decreases in export flux resulting ...
Shams Shiva S IASMA Research and Innovation Centre, Istituto Agrario di S. Michele all'Adige, Fondazione E. Mach, Via E. Mach 1, 38010 S. Michele all'Adige (Trento), Italy; Human and Environmental Toxicology Group, Department of Biology, University of Konstanz, P.O. Box X-918, D-78457 Konstanz, Germany. Electronic address: - - 2013
In this study, we investigated the kinetic aspects of the microcystin (MC) transfer from Planktothrix rubescens to Daphnia magna by carrying out exposure experiments in small simple mesocosms. We hypothesized that higher fractions of toxic cyanobacteria in the diet of grazers would shift the balance towards a greater than linear, ...
Posada-Izquierdo Guiomar D GD Department of Food Science and Technology, University of Cordoba, Campus de Rabanales, Edificio Darwin-C1, 14014 Córdoba, Spain. Electronic address: - - 2013
The purpose of this study was to evaluate and model the growth of Escherichia coli O157:H7 in fresh-cut lettuce submitted to a neutral electrolyzed water (NEW) treatment, packaged in passive modified atmosphere and subsequently stored at different temperatures (4, 8, 13, 16°C) for a maximum of 27days. Results indicated that ...
Abbasian Parandoush P Health Physics and Dosimetry Laboratory, Department of Energy Engineering and Physics, Amir Kabir University of Technology, Tehran, - - 2014
The main purpose of this work was to develop a pharmacokinetic model for the bone pain palliation agent Samarium-153 ethylenediamine tetramethylene phosphonate ([(153)Sm]-EDTMP) in normal rats to analyze the behavior of the complex. The use of compartmental analysis allows a mathematical separation of tissues and organs to determine the concentration ...
Aher Rahul Balasaheb - - 2013
Both a development of resistance to artemisinin monotherapy and lack of effective vaccine against malaria have created the urgent need for the development of new and efficient antimalarial agents. In this background, we have developed here a linear discriminant analysis (LDA) model and a few 3D-pharmacophore models for the classification ...
Sonne Christian C Department of Bioscience, Arctic Research Centre, Aarhus University, Denmark. Electronic address: - - 2013
Human exposure to persistent organic pollutants (POPs) and the potential health impact in the Arctic far from the emission sources have been highlighted in numerous studies. As a supplement to human POP biomonitoring studies, a physiologically based pharmacokinetic (PBPK) model was set up to estimate the fate of POPs in ...
Loerakker Sandra S Department of Biomedical Engineering, Eindhoven University of Technology, P.O. Box 513, 5600 MB , Eindhoven, The Netherlands, - - 2013
Collagen is the main load-bearing component of many soft tissues and has a large influence on the mechanical behavior of tissues when exposed to mechanical loading. Therefore, it is important to increase our understanding of collagen remodeling in soft tissues to understand the mechanisms behind pathologies and to control the ...
Lee Jui-Huan JH Institute of Occupational Medicine and Industrial Hygiene, College of Public Health, National Taiwan University, Taipei, - - 2013
This study is conducted to characterize the intra-urban distribution of NOx and NO2; develop land use regression (LUR) models to assess outdoor NOx and NO2 concentrations, using the ESCAPE modeling approach with locally specific land use data; and compare NOx and NO2 exposures for children in the Taipei Metropolis by ...
Shah Dhaval K DK Department of Pharmaceutical Sciences, University at Buffalo, The State University of New York, 452 Kapoor Hall, Buffalo, NY, 14260, - - 2013
We are investigating an inverse targeting strategy to reduce the dose limiting systemic toxicities resultant from intraperitoneal administration of topotecan, a model chemotherapeutic drug. This approach utilizes systemic co-administration of anti-topotecan antibodies to alter the plasma and tissue disposition kinetics of topotecan. To better predict the effects of 8C2, a ...
Zhao Guoliang G Faculty of Electronic Information and Electronic Engineering, Dalian University of Technology, Dalian 116024, China ; Modern Manufacture Engineering Center, Heilongjiang University of Science and Technology, Harbin 150022, - - 2013
This paper proposes new methodologies for the design of adaptive integral-sliding mode control. A tensor product model transformation based adaptive integral-sliding mode control law with respect to uncertainties and perturbations is studied, while upper bounds on the perturbations and uncertainties are assumed to be unknown. The advantage of proposed controllers ...
Wijesekara Gayan Nishad GN Department of Geomatics Engineering, University of Calgary, Calgary, AB, Canada, - - 2013
The Elbow River watershed in Alberta covers an area of 1,238 km(2) and represents an important source of water for irrigation and municipal use. In addition to being located within the driest area of southern Canada, it is also subjected to considerable pressure for land development due to the rapid ...
Zhang Yejia Y Departments of ‡Orthopedic Surgery, †Biochemistry *Physical Medicine & Rehabilitation, Rush University Medical Center, Chicago, IL; [Black up-pointing triangle]Department of Orthopedic Surgery, Second Hospital of Xiangya, Central South University, Hunan, P. R. China; ΔQujing No. 1 Hospital, Orthopedic Department, Yunnan Province, PR China; #Department of Physical Medicine and Rehabilitation, Perelman School of Medicine, University of Pennsylvania, and Philadelphia VA Medical Center, Philadelphia, - - 2013
Study Design. Histological features of the intervertebral disc/endplate interface were analyzed.Objective. To define cartilaginous and bony vertebral endplate in commonly used laboratory animals and compare with that of the humans.Summary of Background Data. Endplates are crucial for the IVD nutrient supply: the IVDs have limited blood supply; most nutrients diffuse ...
Ishak Mustapha M Department of Physics, The University of Texas at Dallas, Richardson, Texas 75083, - - 2013
Probes of cosmic expansion constitute the main basis for arguments to support or refute a possible apparent acceleration due to different expansion rates in the Universe as described by inhomogeneous cosmological models. We present in this Letter a separate argument based on results from an analysis of the growth rate ...
Sun Xian-Qiang XQ 1] Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China [2] Division of Theoretical Chemistry and Biology, School of Biotechnology, KTH Royal Institute of Technology, S-106 91 Stockholm, - - 2013
Aim:To develop a novel 3D-QSAR approach for study of the epidermal growth factor receptor tyrosine kinase (EGFR TK) and its inhibitors.Methods:One hundred thirty nine EGFR TK inhibitors were classified into 3 clusters. Ensemble docking of these inhibitors with 19 EGFR TK crystal structures was performed. Three protein structures that showed ...
Thomas Trayder - - 2013
We have developed homology models of the acetylcholine muscarinic receptors M1R-M5R, based on the β2-adrenergic receptor crystal as the template. This is the first report of homology modeling of all five subtypes of acetylcholine muscarinic receptors with binding sites optimized for ligand binding. The models were evaluated for their ability ...
Chen Tianju T Key Laboratory of Biofuels, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, 189 Songling Road, Qingdao 266101, PR - - 2013
The gasification kinetic analysis of the three pseudocomponents (hemicellulose, cellulose and lignin) of biomass decomposition in the agent of CO2 were investigated. The Multi-peaks method was used to fit the Gaussian distribution model of DTG curves. The Friedman method was used to estimate the effective Eα, and the master plot ...
Dastoor Ashu P - - 2013
High levels of mercury in marine mammals threaten the health of Arctic inhabitants. Whether the Arctic Ocean (AO) is a sink or a source of atmospheric mercury is unknown. Given the paucity of observations in the Arctic, models are useful in addressing this question. GEOS-Chem and GRAHM, two complex numerical ...
Sweeney Lisa M LM Henry M. Jackson Foundation for the Advancement of Military Medicine, Naval Medical Research Unit Dayton, Wright-Patterson AFB, OH - - 2013
The ten Berge model, also known as the toxic load model, is an empirical approach in hazard assessment modeling for estimating the relationship between the inhalation toxicity of a chemical and the exposure duration. The toxic load (TL) is normally expressed as a function of vapor concentration (C) and duration ...
Faraj Chafika - - 2013
In Morocco, the main strategies of leishmaniasis vector control are based on environmental modifications. Use of local residual indoor spraying with synthetic pyrethroids is often envisaged. The need to evaluate this control method is essential. The current study was conducted to determine the efficacy of an alphacypermethrin IRS program against ...
Tang Min M Ewha Womans University, - - 2013
We present fast CCD algorithm for general rigid and articulated models based on conservative advancement. We have implemented the CCD algorithm with two different acceleration techniques which can handle rigid models, and have extended one of them to articulated models. The resulting algorithms take a few milliseconds for rigid models ...
Taffetani M M Department of Chemistry, Materials and Chemical Engineering, Laboratory of Biological Structure Mechanics (LaBS), Politecnico di Milano, Milano, Italy. Electronic address: - - 2013
Articular cartilage is a soft hydrated tissue that facilitates proper load transfer in diarthroidal joints. The mechanical properties of articular cartilage derive from its structural and hierarchical organization that, at the micrometric length scale, encompasses three main components: a network of insoluble collagen fibrils, negatively charged macromolecules and a porous ...
Poniatowski Lauren H - - 2013
Background: The objective was to determine the acceptability and preliminary construct validity for a high-fidelity synthetic renal pelvis/ureter tissue analogue model for use as a simulation model for training laparoscopic pyeloplasty. Methods: The pyeloplasty model was designed with incorporated assessment lines for use in post-task Black Light Assessment of Surgical ...
Waran Vicknes - - 2013
The advent of multimaterial 3D printers allows the creation of neurosurgical models of a more realistic nature, mimicking real tissues. The authors used the latest generation of 3D printer to create a model, with an inbuilt pathological entity, of varying consistency and density. Using this model the authors were able ...
Grenier Stephanie S Laboratory for Soft Tissue Research, Tissue Engineering, Regeneration and Repair Program, The Hospital for Special Surgery, New York, NY 10021, United States. Electronic address: - - 2013
The objective of this study was to develop an in vitro cartilage degradation model that emulates the damage seen in early-stage osteoarthritis. To this end, cartilage explants were collagenase-treated to induce enzymatic degradation of collagen fibers and proteoglycans at the articular surface. To assess changes in mechanical properties, intact and ...
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