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Results 301 - 350 of 2144
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He Ran - - 2013
Low-rank matrix recovery algorithms aim to recover a corrupted low-rank matrix with sparse errors. However, corrupted errors may not be sparse in real-world problems and the relationship between L1 regularizer on noise and robust M-estimators is still unknown. This paper proposes a general robust framework for low-rank matrix recovery via ...
Hutsell Blake A - - 2013
Rats responded in a six-stimulus, two-response temporal classification procedure. A successive-reversal design was used in which the relationship between stimulus class (short vs. long) and correct comparison location (left or right) reversed every 15 sessions. After several reversals, the relative probability of reinforcement for each correct classification was manipulated across ...
Facchinetti Andrea - - 2013
Continuous glucose monitoring (CGM) sensors are portable devices, employed in the treatment of diabetes, able to measure glucose concentration in the interstitium almost continuously for several days. However, CGM sensors are not as accurate as standard blood glucose (BG) meters. Studies comparing CGM vs BG demonstrated that CGM is affected ...
Cattelan Manuela - - 2013
The study of the determinants of fights between animals is an important issue in understanding animal behavior. For this purpose, tournament experiments among a set of animals are often used by zoologists. The results of these tournament experiments are naturally analyzed by paired comparison models. Proper statistical analysis of these ...
David Ingrid - - 2013
The pre-weaning growth of lambs, an important component of meat production, depends on maternal and direct effects. These effects cannot be observed directly and models used to study pre-weaning growth assume that they are additive. However, it is reasonable to suggest that the influence of direct effects on growth may ...
Zhu Xi - - 2013
In this paper, robust control problem using μ-synthesis in microbial continuous culture is studied. The dissimilation process of glycerol to 1,3-propanediol cannot avoid the disturbances caused by uncertain factors. Based on the biodynamical model, a control system with the initial glycerol concentration as input control is proposed to simplify the controller ...
Muthukumar M - - 2013
A thermodynamic model is used to investigate the conditions under which clathrin triskelions form polyhedral baskets. The analysis, which is similar to classical methods used to study micelle formation, relates clathrin basket energetics to system parameters linked to triskelial rigidity, the natural curvature of an isolated triskelion, and interactions between ...
Zhou Xiang - - 2013
Dietzia natronolimnaea is one of the most important bacterial bioresources for high efficiency canthaxanthin production. It produces the robust and stable pigment canthaxanthin, which is of special interest for the development of integrated biorefineries. Mutagenesis employing 12C6+ irradiation is a novel technique commonly used to improve microorganism productivity. This study ...
Olivares-Morales Andrés - - 2013
To develop and evaluate a tool for the qualitative prediction of human oral bioavailability (Fhuman) from animal oral bioavailability (Fanimal) data employing ROC analysis and to identify the optimal thresholds for such predictions. A dataset of 184 compounds with known Fhuman and Fanimal in at least one species (mouse, rat, ...
Sartini Claudio - - 2013
The aim of this study was to investigate the influence of an urban area on ultrafine particle (UFP) concentration in nearby surrounding areas. We assessed how downwind and upwind conditions affect the UFP concentration at a site placed a few kilometres from the city border. Secondarily, we investigated the relationship ...
Huang Gongsheng - - 2013
This paper shows how to apply generalized eigenvalue minimization to processes that can be described by a first-order plus time-delay model with uncertain gain, time constant and delay. An algorithm to transform the uncertain first-order plus time delay model into a state-space model with uncertainty polyhedron is firstly described. The ...
Weijs Liesbeth - - 2013
Physiologically based pharmacokinetic (PBPK) models for wild animal populations such as marine mammals typically have a high degree of model uncertainty and variability due to the scarcity of information and the embryonic nature of this field. Parameters values used in marine mammals models are usually taken from other mammalian species ...
Gibson Luke - - 2013
Tropical forests continue to be felled and fragmented around the world. A key question is how rapidly species disappear from forest fragments and how quickly humans must restore forest connectivity to minimize extinctions. We surveyed small mammals on forest islands in Chiew Larn Reservoir in Thailand 5 to 7 and ...
Morfeld Peter - - 2013
Gebel (In Arch Toxicol 87(5):923-924, 2013) replied to my Letter to the Editor (Morfeld in Arch Toxicol 87(5):921, 2013) in which I criticized the quantitative review of inhalation rat studies on the association of granular biopersistent dust exposures and lung cancer risk (Gebel in Arch Toxicol 86(7):995-1007, 2012). My methodological ...
Wang Ning - - 2013
Ulinastatin is a potent multivalent serine protease inhibitor, which was recently found with therapeutic potentials in treating sepsis, and the most life-threatening complication of critically ill population. However, the pharmacological features and possible mechanisms need to be further elucidated in reliable and clinical relevant sepsis models. As known, sepsis induced ...
Squartini Tiziano - - 2013
In directed networks, reciprocal links have dramatic effects on dynamical processes, network growth, and higher-order structures such as motifs and communities. While the reciprocity of binary networks has been extensively studied, that of weighted networks is still poorly understood, implying an ever-increasing gap between the availability of weighted network data ...
Tilocca Antonio - - 2013
A set of molecular dynamics simulations were performed to investigate the effect of cooling rate and system size on the medium-range structure of melt-derived multicomponent silicate glasses, represented by the quaternary 45S5 Bioglass composition. Given the significant impact of the glass degradation on applications of these materials in biomedicine and ...
Chaturvedula Ayyappa - - 2013
An automated model development was performed for simvastatin, co-administered with amlodipine concurrently or non-concurrently (i.e., 4 hours later) in 17 patients with coexisting hyperlipidemia and hypertension. The single objective hybrid genetic algorithm (SOHGA) was implemented in the NONMEM software by defining the search space for structural, statistical and covariate models. Candidate ...
Limnuson Kanokwan - - 2013
This paper presents an infinite impulse response (IIR) temporal filtering technique for real-time stimulus artifact rejection (SAR) based on template subtraction. A system architecture for the IIR SAR algorithm is developed, and the operation of the algorithm with fixed-point computation is analyzed to obtain the number of bits for the ...
Qvarlander Sara - - 2013
Introduction The physiological effect of posture on intracranial pressure (ICP) is not well described. This study defined and evaluated three mathematical models describing the postural effects on ICP, designed to predict ICP at different head-up tilt-angles from the supine ICP value. Methods Model I was based on a hydrostatic indifference ...
Lewis Benjamin C - - 2013
In vitro validation of a protein homology model is critical for determining the predictivity of a computationally generated structure. Here we discuss the generation, validation, and application of a homology model for CYP1A1. Validation of the CYP1A1 homology model, generated using the highly homologous crystal template of human CYP1A2 (pdb ...
Pizarro J - - 2013
Understanding the interaction between anthropogenic land use and the rainfall pattern can be crucial to predict changes in total suspended solids (TSS) in streams and rivers. We assessed the effects of land use and annual rainfall on the TSS load of 19 southern Chilean catchments. The results indicated that the ...
Heigl Nicolas - - 2013
Quantitative dehydration studies of dibasic calcium phosphate anhydrous (DCPA) in a smallscale cold-model fluidized bed dryer with process air control were conducted. Near-infrared spectroscopy (NIRS) with partial least squares regression (PLSR) was used to predict DCPAś residual moisture content. Loss-on-drying (LOD) was employed as a reference method and confirmed the ...
Márquez G C - - 2013
Days to harvest (DTH) is the number of days a lamb is fed before reaching a target level of fatness. Although economically relevant, this trait has not been thoroughly evaluated in sheep. Most lambs harvested in the UK are crossbreds sired by purebred terminal sires, with Charollais, Suffolk and Texel ...
Lendrem Dennis W - - 2013
In the 1990s the pharmaceutical industry sought to increase R&D productivity by shifting development tasks into parallel to reduce development cycle times and increase development speed. This paper presents a simple model demonstrating that, when attrition rates are high as in pharmaceutical development, such development speed initiatives can increase the ...
Nöremark Maria - - 2013
In addition to livestock movements, other between-farm contacts such as visitors may contribute to the spread of contagious animal diseases. Knowledge about such contacts is essential for contingency planning. Preventive measures, risk-based surveillance and contact tracing may be facilitated if the frequency and type of between-farm contacts can be assessed ...
Herrmann Patricia A - - 2013
What kinds of cues increase imitative fidelity in early childhood? The effects of multiple models and verbal framing were examined in preschool children (N=259, 3-6-year-olds). Each participant was presented with one of eight possible combinations of type of modeling and verbal frame. The type of modeling involved: (i) a single ...
Phillips Priscilla L - - 2013
An ex vivo porcine skin explant biofilm model that preserves key properties of biofilm attached to skin at different levels of maturity (0-3 days) was used to assess the efficacy of commercially available antimicrobial dressings and topical treatments. Assays were also performed on the subpopulation of antibiotic tolerant biofilm generated by ...
Mabbitt Peter D - - 2013
Psb27 associates with the CP43 subunit of photosystem II during biogenesis of the photosystem. Several models have been proposed for the interaction between Psb27 and CP43. The utility of predictions and hypotheses arising from these models depends on the accuracy of the Psb27 structure used in the model. Two of ...
Huang Xiao-Wu - - 2013
Kinetics of anaerobic ammonium oxidation (anammox) reaction in marine anammox bacterial culture was first investigated. The nitrogen removal performance of the reactor was compared with prediction of Monod model, modified Stover-Kincannon model, first-order and the Grau second-order substrate removal models. Based on calculations, Monod model, modified Stover-Kincannon model and the ...
van den Abbeele Pieter - - 2013
Different in vitro models have been developed to assess how food compounds affect the human gut microbiota. Using two such models (SHIME® and TIM-2), we compared how long-chain arabinoxylan (LC-AX), a wheat-derived potentially prebiotic fiber, and inulin (IN), a well-established prebiotic compound, modulate SCFA production and bifidobacteria composition. While both ...
Yuan Zhengzhong - - 2013
Controlling complex networks is of paramount importance in science and engineering. Despite the recent development of structural controllability theory, we continue to lack a framework to control undirected complex networks, especially given link weights. Here we introduce an exact controllability paradigm based on the maximum multiplicity to identify the minimum ...
Zhang Liang - - 2013
This note describes an improved equivalent circuit analysis model for open-ended coaxial probes for measurement of the dielectric properties of biological tissues below the gigahertz level. Some parameters in the conventional model that influence the measurement results were found to be still relative to the dielectric properties of the test ...
Wang Qiaoyun - - 2013
The origin of trifluoroacetic acid (TFA) occurring in hydrosphere has long been a controversial issue. Hydrochlorofluorocarbons and hydrofluorocarbons (HCFCs/HFCs) as replacements of chlorofluorocarbons (CFCs) are precursors of TFA in the atmosphere, their contribution to rainwater TFA is a concern as their ambient mixing ratios are continually growing. Here we present ...
Sayama Hiroyuki - - 2013
Accurate prediction of pharmacokinetics (PK) in humans has been a vital part of drug discovery. The aims of this study are to verify the usefulness of scaling factors for clearance (CL) and apparent volume of distribution at the steady state (Vss ) estimated from the difference between observed and predicted ...
Jinno S - - 2013
A detailed mathematical model is presented for a submicron-sized cluster formation in a binary gas mixture flowing through a three-staged conical nozzle. By measuring the angular distribution of light scattered from the clusters, the size of CO<sub>2</sub> clusters, produced in a supersonic expansion of the mixture gas of CO<sub>2</sub>(30%)/H<sub>2</sub>(70%) or ...
Coquebert de Neuville Bertrand - - 2013
Chromatographic stationary phases such as Fractogel EMD SO3 (M) have a pore size distribution that is close to the size of proteins. The accessible porosity and the mass transfer inside the particles are therefore strongly affected by the pore to solute size ratio. This effect was simulated using the distributed ...
Carreira João Casaca - - 2013
Several animal models for Huntington's disease (HD) have been created in order to investigate mechanisms of disease, and to evaluate the potency of novel therapies. Here, we describe the characteristics of the two transgenic rat models: transgenic rat model of HD (fragment model) and the Bacterial Artificial Chromosome HD model ...
Hansen Anne M - - 2013
We provide a longer-term record of Hg wet deposition at two tropical latitude monitoring sites in Mexico, selected to provide regionally representative data. Weekly wet deposition samples were collected over 2 years, from September 2003 to November 2005. Based on this data set, we discuss the magnitude and seasonal variation of ...
Ferreira A R - - 2013
In this paper, we implemented a model-based optimization platform for fast development of Pichia pastoris cultures employing batch-to-batch control and hybrid semi-parametric modeling. We illustrate the methodology with a P. pastoris GS115 strain expressing a single-chain antibody fragment (scFv) by determining the optimal time profiles of temperature, pH, glycerol feeding ...
Diestelhorst Christian - - 2013
A physiologically based pharmacokinetic (PBPK) model was established and evaluated describing the pharmacokinetics (PK) of the DNA-alkylating agent Busulfan in adults in order to predict the systemic Busulfan drug exposure in both plasma and toxicity-related organs. A generic PBPK model was tailored to describe Busulfan PK by implementing compound-specific physicochemical ...
Venrooij Joost - - 2013
Biodynamic feedthrough (BDFT) occurs when vehicle accelerations feed through the human body and cause involuntary control inputs. This paper proposes a model to quantitatively predict this effect in rotorcraft. This mathematical BDFT model aims to fill the gap between the currently existing black box BDFT models and physical BDFT models. ...
Liu Yufeng Y MOE Key Laboratory of Bioinformatics, School of Life Sciences, Tsinghua University, Beijing, - - 2013
Although molecular dynamics simulations can be accelerated by more than an order of magnitude by implicitly describing the influence of the solvent with a continuum model, most currently available implicit solvent simulations cannot robustly simulate the structure and dynamics of nucleic acids. The difficulties become exacerbated especially for RNAs, suggesting ...
Ogawa Yasuhiro - - 2013
We numerically calculated the photonic band structure of a cholesteric blue phase II (BPII) liquid crystal using two models, the tensor order parameter model and the double-twist cylinder (DTC) model. The tensor order parameter model was derived numerically from the Landau-de Gennes theory, whereas the DTC model simply assumed a ...
Marx David M - - 2013
Past work has shown that female role models are effective buffers against stereotype threat. The present research examines the boundary conditions of this role model effect. Specifically, we argue that female role models should avoid expressing doubt about their math abilities; otherwise they may cease to buffer women from stereotype ...
Vyas Vivek K - - 2013
This study investigated 3D quantitative structure-activity relationships (QSAR) for a range of substituted benzimidazole derivatives as AngII-AT1 receptor antagonists by comparative molecular field analysis (CoMFA) and comparative molecular similarity indices (CoMSIA). The alignment strategy was used for these compounds by means of Distill function defined in SYBYL X 1.2. The ...
Mapp P I - - 2013
To characterize differences in joint pathology and pain behavior between two rat models of osteoarthritis (OA) in order to inform selection of animal models for interventional studies. Knee OA was induced in Sprague Dawley rats by either meniscal transection (MNX) or intra-articular injection of monosodium iodoacetate (MIA). Controls were subjected ...
Mitchinson Ben - - 2013
Spatial attention is most often investigated in the visual modality through measurement of eye movements, with primates, including humans, a widely-studied model. Its study in laboratory rodents, such as mice and rats, requires different techniques, owing to the lack of a visual fovea and the particular ethological relevance of orienting ...
Kim Sang-Woo - - 2013
Osteoporosis is a known major health problem and a serious disease of the bone, there has been a great need to develop more and newer animal models for this disease. Among animal models used for testing drug efficacy, the minipig model has become useful and effective due to its close ...
Azwandi A - - 2013
Decomposing carrion provides a temporary microhabitat and food source for a distinct community of organisms. Arthropods constitute a major part of this community and can be utilized to estimate the postmortem interval (PMI) of cadavers during criminal investigations. However, in Malaysia, knowledge of carrion arthropod assemblages and their succession is ...
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