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Results 251 - 300 of 2430
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Zhou Hua H North Carolina State University, Raleigh, - - 2014
Modern technologies are producing a wealth of data with complex structures. For instance, in two-dimensional digital imaging, flow cytometry and electroencephalography, matrix-type covariates frequently arise when measurements are obtained for each combination of two underlying variables. To address scientific questions arising from those data, new regression methods that take matrices ...
Wang Eric X - - 2014
A method for probability density function (PDF) estimation using Bayesian mixtures of weighted gamma distributions, called the Dirichlet process gamma mixture model (DP-GaMM), is presented and applied to the analysis of a laser beam in turbulence. The problem is cast in a Bayesian setting, with the mixture model itself treated ...
Broms Kristin M - - 2014
Determining the range of a species and exploring species--habitat associations are central questions in ecology and can be answered by analyzing presence--absence data. Often, both the sampling of sites and the desired area of inference involve neighboring sites; thus, positive spatial autocorrelation between these sites is expected. Using survey data ...
Risse Sarah S University of Potsdam, Potsdam, - - 2014
Eye-movement experiments suggest that the perceptual span during reading is larger than the fixated word, asymmetric around the fixation position, and shrinks in size contingent on the foveal processing load. We used the SWIFT model of eye-movement control during reading to test these hypotheses and their implications under the assumption ...
Kawai Toru - - 2014
We propose a new metric for long-range transport potential (LRTP), GIF, based on source-receptor analyses, and evaluate the LRTP and persistence of a wide variety of chlorinated and brominated organic compounds using GIF and overall persistence (POV). We calculated GIF and POV using our global 3D dynamic multimedia model (FATE). ...
Peck Yvonne - - 2014
Osteoarthritis (OA) is primarily characterized by focal cartilage destruction and synovitis. Presently, the pathogenesis of OA remains unclear and an effective treatment methodology is an unmet need. To this end, a plethora of animal models and monolayer models have been developed but they are faced with the limitation of high ...
Fukahori Shuji S New Paper Industry Program Center, Faculty of Agriculture, Ehime University, Japan; Japan Science and Technology Agency, CREST, Japan. Electronic address: - - 2014
TiO2/high-silica zeolite composite synthesized by a sol-gel method was applied for the removal of sulfamethazine (SMT) antibiotic from water, and simple models including both adsorption and photocatalytic decomposition were developed. In this study, two types of models were constructed: a synergistic model that included the interaction between the zeolite and ...
Martelo-Vidal M J MJ Department of Analytical Chemistry, Faculty of Veterinary Science, University of Santiago de Compostela, Calle Carballo Calero, s/n, 27002 Lugo, - - 2014
Spectral analysis is a quick and non-destructive method to analyse wine. In this work, trans-resveratrol, oenin, malvin, catechin, epicatechin, quercetin and syringic acid were determined in commercial red wines from DO Rías Baixas and DO Ribeira Sacra (Spain) by UV-VIS-NIR spectroscopy. Calibration models were developed using principal component regression (PCR) ...
Carey Hannah V HV Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin Madison, Madison, WI 53705, United States. Electronic address: - - 2014
The environments in which animals have evolved and live have profound effects on all aspects of their biology. Predictable rhythmic changes in the physical environment are arguably among the most important forces shaping the evolution of behavior and physiology of animals, and to anticipate and prepare for these predictable changes, ...
Zhao Yun-Bo - - 2014
mRNA translation involves simultaneous movement of multiple ribosomes on the mRNA and is also subject to regulatory mechanisms at different stages. Translation can be described by various codon-based models, including ODE, TASEP, and Petri net models. Although such models have been extensively used, the overlap and differences between these models ...
Huang Haomin H Institute of Environmental Science and Technology, College of Environmental and Resource Science (CERS), Zhejiang University, Nongshenghuan Building B323, Number 388 Yuhangtang Road, Zijingang Campus, Hangzhou, 310058, - - 2014
The occurrence of harmful algal blooms has been increasing significantly around the world. In order to ensure the safety of drinking water, procedures to screen potential materials as effective algicides are needed, and predictive methods which save both the labor and time compared with traditional experimental approaches, are particularly desirable. ...
Yan Qi-Long QL Institute of Energetic Materials, Faculty of Chemical Technology, University of Pardubice, 53210 Pardubice, Czech Republic; Instituto de Ciencia de Materiales de Sevilla, CSIC-Universidad de Sevilla, C. Américo Vespucio No. 49, 41092 Sevilla, Spain. Electronic address: - - 2014
In this paper, the decomposition reaction models and thermal hazard properties of 1,3,5-trinitro-1,3,5-triazinane (RDX) and its PBXs bonded by Formex P1, Semtex 1A, C4, Viton A and Fluorel polymer matrices have been investigated based on isoconversional and combined kinetic analysis methods. The established kinetic triplets are used to predict the ...
Nsir K K CNRS, Laboratoire Réactions et Génie de Procédés, UMR 7274, 1 rue Grandville, BP 20451, 54001 Nancy, France; Université de Lorraine, Laboratoire Réactions et Génie de Procédés, UMR 7274, 1 rue Grandville, BP 20451, 54001 Nancy, - - 2014
The present work deals with the modeling of selenium oxyanion (selenite/selenate) retention in TiO2 rutile porous media. A set of chemical interactions was elaborated from spectroscopic measurements and adsorption experiments in batch and column reactors, and a model of transient transport of the selenium species through laboratory column was developed. ...
Lurker Peter A PA Germantown Consultants, LLC, Germantown, OH, - - 2014
During the Vietnam War, approximately 20 million gallons of herbicides, including ~10.5 million gallons of dioxin-contaminated Agent Orange, were sprayed by about 34 UC-123 aircraft that were subsequently returned to the United States, without decontamination or testing, to three Air Force reserve units for transport operations (~1971-1982). In 1996, observed ...
Nie Xuqing - - 2014
The smoothing effect of the rigid lap plays an important role in controlling midspatial frequency errors (MSFRs). At present, the pressure distribution between the polishing pad and processed surface is mainly calculated by Mehta's bridging model. However, this classic model does not work for the irregular MSFR. In this paper, ...
Boonpawa Rungnapa R Division of Toxicology, Wageningen University, Tuinlaan 5, 6703 HE Wageningen, The Netherlands. Electronic address: - - 2014
Biological activities of flavonoids in vivo are ultimately dependent on the systemic bioavailability of the aglycones as well as their metabolites. In the present study, a physiologically based kinetic (PBK) model was developed to predict plasma concentrations of the flavonoid quercetin and its metabolites and to tentatively identify the regiospecificity ...
McGrath Justin M JM 1 University of Illinois, - - 2014
Experimental elevation of [CO2] around C3 crops in the field has been shown to increase yields by suppressing the Rubisco oxygenase reaction and in turn photorespiration. Bioengineering a cyanobacterial carbon-concentration mechanism (CCM) into C3 crop species provides a potential means of elevating [CO2] at Rubisco, thereby decreasing photorespiration and increasing ...
Mustoe Anthony M - - 2014
Recent studies have shown that simple stereochemical constraints encoded at the RNA secondary structure level significantly restrict the orientation of RNA helices across two- way junctions and yield physically reasonable distributions of RNA 3D conformations. Here we develop a new coarse-grain model, TOPRNA, that is optimized for exploring detailed aspects ...
Luo Zijun - - 2014
The miRNAs are small non-coding RNAs of roughly 22 nucleotides in length, which can bind with and inhibit protein coding mRNAs through complementary base pairing. By degrading mRNAs and repressing proteins, miRNAs regulate the cell signaling and cell functions. This paper focuses on innovative mathematical techniques to model gene interactions ...
Fontanella C G CG Centre of Mechanics of Biological Materials, University of Padova, Padova, - - 2014
The aim of this work was to provide computational tools for the characterization of the actual mechanical behaviour of foot skin, accounting for results from experimental testing and histological investigation. Such results show the typical features of skin mechanics, such as anisotropic configuration, almost incompressible behaviour, material and geometrical non ...
Gutting Bradford B Bradford Gutting, PhD, is a Toxicologist, Naval Surface Warfare Center Dahlgren Division (NSWCDD) , Dahlgren, - - 2014
Computational models describing bacterial kinetics were developed for inhalational anthrax in New Zealand white (NZW) rabbits following inhalation of Ames strain B. anthracis. The data used to parameterize the models included bacterial numbers in the airways, lung tissue, draining lymph nodes, and blood. Initial bacterial numbers were deposited spore dose. ...
Castañeda-Bustos V J VJ Colegio de Postgraduados, Campus Montecillo, Montecillo, Estado de México 56230, - - 2014
Heritabilities and correlations for milk yield (MY), fat yield (FY), protein yield (PY), combined fat and protein yield (FPY), fat percentage (F%), protein percentage (P%), age at first kidding (AFK), interval between the first and second kidding (KI), and real and functional productive life at 72 mo (FPL72) of 33,725 ...
Rouder Jeffrey N JN University of Missouri, Columbia, MO, USA, - - 2014
We present a cognitive process model of response choice and response time performance data that has excellent psychometric properties and may be used in a wide variety of contexts. In the model there is an accumulator associated with each response option. These accumulators have bounds, and the first accumulator to ...
Tabanelli Giulia G Centro Interdipartimentale di Ricerca Industriale Agroalimentare, Univ. degli Studi di Bologna, Sede di Cesena, Piazza Goidanich 60, 47521, Cesena, (FC), - - 2014
The antimicrobial effects of 2 terpenes (citral and linalool) on a Saccharomyces cerevisiae strain isolated from spoiled soft drink have been evaluated, alone or in combination, in relation to pH and aw using in vitro assays. The obtained data were fitted with the logit model to find the growth/no growth ...
Katsube Takayuki T Clinical Research Department, Shionogi and Company, Ltd., Shibata 1-1-4, Kita-ku, Osaka, 530-0012, - - 2014
The aim of this study was to develop a pharmacokinetic (PK)/pharmacodynamic (PD) model of a bicyclolide, modithromycin, to explain its concentration-dependent bactericidal activity based on the drug-bacterium interaction model that we developed. We have already reported the applicability of model to the time-dependent activity of β-lactams, and we further applied ...
Baneyx Guillaume G F.Hoffmann-La Roche AG, pRED, Pharma Research and Early Development, Non-Clinical Safety, Basel, Switzerland. Electronic address: - - 2014
The induction of cytochrome P450 enzymes (CYPs) is an important source of drug-drug interaction (DDI) and can result in pronounced changes in pharmacokinetics (PK). Rifampicin (RIF) is a potent inducer of CYP3A4 and also acts as a competitive inhibitor which can partially mask the induction. The objective of this study ...
Chisholm Ryan A RA Department of Biological Sciences, National University of Singapore, 117543, Singapore. Electronic address: - - 2014
Biogeography seeks to understand the mechanisms that drive biodiversity across long temporal and large spatial scales. Theoretical models of biogeography can be tested by comparing their predictions of quantities such as species ages against empirical estimates. It has previously been claimed that the neutral theory of biodiversity and biogeography predicts ...
Kooijman Sebastiaan A L M SA Department of Theoretical Biology, VU University Amsterdam, de Boelelaan 1087, 1081 HV, Amsterdam, The - - 2014
The standard Dynamic Energy Budget (DEB) model assumes that a fraction κ of mobilised reserve is allocated to somatic maintenance plus growth, while the rest is allocated to maturity maintenance plus maturation (in embryos and juveniles) or reproduction (in adults). All DEB parameters have been estimated for 276 animal species ...
Nardi Francesco F Department of Life Sciences, University of Siena. Via Aldo Moro 2, 53100 Siena, Italy. Electronic address: - - 2014
Phylogenetic analyses of Pancrustacea have generally relied on empirical models of amino acid substitution estimated from large reference datasets and applied to the entire alignment. More recently, following the observation that different sites, or groups of sites, may evolve under different evolutionary constraints, methods have been developed to deal with ...
Ng Daphne T W DT Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, - - 2014
High-efficiency DNA ligation is vital for many molecular biology experiments and it is best achieved using reactants with non-palindromic sticky ends to maximize specificity. However, optimizing such multi-parametric ligation reactions often involves extensive trial and error. We have developed a freely-available web-based ligation calculator, NP-Sticky, that predicts product distribution for ...
Tyzio Roman R Mediterranean Institute of Neurobiology (INMED), U901, INSERM, Marseille, - - 2014
We report that the oxytocin-mediated neuroprotective γ-aminobutyric acid (GABA) excitatory-inhibitory shift during delivery is abolished in the valproate and fragile X rodent models of autism. During delivery and subsequently, hippocampal neurons in these models have elevated intracellular chloride levels, increased excitatory GABA, enhanced glutamatergic activity, and elevated gamma oscillations. Maternal ...
Belanche A A Institute of Biological, Environmental and Rural Sciences, Aberystwyth University, SY23 3DA, Aberystwyth, United - - 2014
This study explored the potential of partial least squares (PLS) and Fourier-transform infrared spectroscopy (FTIR) to predict rumen dry matter (DM) and neutral detergent fiber (NDF) degradation parameters of a wide range of feeds for ruminants, as an alternative to the in situ method. In total, 663 samples comprising 80 ...
Shapiro Liza J LJ Department of Anthropology, University of Texas at Austin, 2201 Speedway, Stop C3200, Austin, TX 78712, USA. Electronic address: - - 2014
Recently proposed ancestral locomotor and morphological 'stages' leading to the evolution of primates have emphasized small body size, and a transition from a clawed non-grasping stage, to a clawed, grasping stage with clawless opposable hallux, to a fully-nailed primate with grasping extremities. This evolutionary transition was presumably associated with frequent ...
Shah Dhaval K DK Department of Pharmaceutical Sciences, University at Buffalo, The State University of New York, Buffalo, NY 14214, United - - 2014
To facilitate the development of an inverse targeting strategy, where anti-topotecan antibodies are administered to prevent systemic toxicity following intraperitoneal topotecan, a pharmacokinetic/toxicodynamic (PK/TD) model was developed and evaluated. The pharmacokinetics of 8C2, a monoclonal anti-topotecan antibody, were assessed following IV and SC administration, and the data were characterized using ...
Sindhu Thangaraj T Department of Bioinformatics, Alagappa University , Karaikudi, Tamilnadu , - - 2014
Abstract Farnesoid X receptor (FXR) is a potential therapeutic target for the treatment of diabetes mellitus. Atom-based three-dimensional quantitative structure activity relationship (3D-QSAR) models were developed for a series of 48 benzimidazole-based agonists of FXR. A total of five pharmacophore hypotheses were generated based on the survival score to build ...
Alsaaod Maher - - 2014
Anaesthesia is mandatory for disbudding and castrating calves and lambs of any age, in Switzerland. According to the "anaesthesia delegation model" (ADM), anaesthesia for disbudding calves <3 weeks of age and castrating calves and lambs <2 weeks of age may be administered by certified farmers. Experience with this unique model ...
Prunières G J-C GJ Department of hand surgery, Strasbourg university hospital, 10, avenue Baumann, 67403 Illkirch, - - 2014
The aim of this study was to test the feasibility of a type of Japanese noodle, named "shirataki konnyaku", for microsurgery training in the operating room. Thirteen surgical residents without experience in microsurgery had to perform two microsurgical anastomoses: one on a model of a femoral artery of a rat ...
Sales J J Institute of Animal Science, Uhříněves, Prague, Czech - - 2014
Mathematical modelling of the relationships between mineral inputs and outputs would enable the prediction of mineral requirements of poultry under a wide range of conditions. To establish the feasibility of possible modelling of mineral requirements, the current study aimed to describe the individual mineral concentrations of whole bodies of quail ...
Lesaint Florian F Institut des Systèmes Intelligents et de Robotique, UMR 7222, UPMC Univ Paris 06, Paris, France ; Institut des Systèmes Intelligents et de Robotique, UMR 7222, CNRS, Paris, - - 2014
Reinforcement Learning has greatly influenced models of conditioning, providing powerful explanations of acquired behaviour and underlying physiological observations. However, in recent autoshaping experiments in rats, variation in the form of Pavlovian conditioned responses (CRs) and associated dopamine activity, have questioned the classical hypothesis that phasic dopamine activity corresponds to a ...
Rieppo Lassi L University of Eastern Finland, Department of Applied Physics, FI-70211 Kuopio, FinlandbKuopio University Hospital, Department of Clinical Neurophysiology, FI-70029 Kuopio, - - 2014
Articular cartilage (AC) is mainly composed of collagen, proteoglycans, chondrocytes, and water. These constituents are inhomogeneously distributed to provide unique biomechanical properties to the tissue. Characterization of the spatial distribution of these components in AC is important for understanding the function of the tissue and progress of osteoarthritis. Fourier transform ...
Dube B B Department of Animal Sciences, Stellenbosch University, Matielend, South - - 2014
Variance components for production traits were estimated using different models to evaluate maternal effects. Data analysed were records from the South African pig performance testing scheme on 22 224 pigs from 18 herds, tested between 1990 and 2008. The traits analysed were backfat thickness (BFAT), test period weight gain (TPG), lifetime ...
Caccamo M M CoRFiLaC, Regione Siciliana, 97100 Ragusa, Italy. Electronic address: - - 2014
As part of a larger project aiming to develop management evaluation tools based on results from test-day (TD) models, the objective of this study was to examine the effect of physical composition of total mixed rations (TMR) tested quarterly from March 2006 through December 2008 on milk, fat, and protein ...
Pauluhn Jürgen J Toxicology, Bayer Pharma, 42096 Wuppertal, Germany. Electronic address: - - 2014
Convincing evidence suggests that high-surface-activity nano-materials, such as MWCNT, exert two modes of action (MoA), in which one appears to be related to surface activity/area and occurs concurrent with deposition, and the other is related to cumulative lung burden. Pulmonary inflammation induced by the latter mode appears to be dependent ...
Hu Zhe-Yi ZY Department of Clinical Pharmacy, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN, - - 2014
Alvespimycin, a new generation of Hsp90 inhibitor in clinical trial, is a promising therapeutic agent for cancer. Pharmacokinetic models of alvespimycin would aid in understanding drug disposition, predicting drug exposure and interpreting dose-response relationship. The present study aims to develop a PBPK model of alvespimycin in mice and evaluate the ...
Lu Liangjian L 1University of - - 2014
The Na(+)-K(+)-2Cl(-) co-transporter NKCC2 is exclusively expressed in the renal thick ascending limb (TAL), where it exists as 3 main splice isoforms, NKCC2B, NKCC2A and NKCC2F, with the latter two predominating. NKCC2A is expressed in both medullary and cortical TAL, but NKCC2F localizes to the medullary TAL. The biochemical characteristics ...
Kale Sohan S Department of Mechanical Science and Engineering, Institute for Condensed Matter Theory and Beckman Institute, University of Illinois at Urbana-Champaign, Urbana, Illinois 61820, - - 2014
A spring lattice model with the ability to simulate elastic-plastic-brittle transitions in a disordered medium is presented. The model is based on bilinear constitutive law defined at the spring level and power-law-type disorder introduced in the yield and failure limits of the springs. The key parameters of the proposed model ...
Baker Tracie R TR Molecular and Environmental Toxicology Center, and Pharmaceutical Sciences, University of Wisconsin, Madison, WI - - 2014
2,3,7,8 Tetrachlorodibenzo-p-dioxin (TCDD) has been associated with many disease states in humans. A rising concern is that exposure early in life can lead to adult toxicity and toxicity in subsequent generations. Juvenile zebrafish exposed to TCDD (50 pg/ml in water; 1 h exposure) at 3 and 7 weeks post fertilization ...
Li Xingang X Department of Pharmaceutics, School of Pharmaceutical Sciences, Peking University Health Science Center , Beijing , People's Republic of China - - 2014
Abstract Modeling and simulation are aimed at achieving information about the behaviors of the drugs without the actual measurements and determination. The purpose of this study was to characterize the in vivo behavior of exenatide microspheres using model-based methods. Exenatide is a glucagon-like peptide-1 agonist medication, belonging to the group ...
Nielsen Hanne M - - 2014
The aim of the study was to estimate genetic parameters for direct and social genetic effects (SGE) for growth and welfare traits in farmed Atlantic cod (Gadus morhua). A SGE refers to the effect of an individual's genes on trait performance of its social partners. In total, 2100 individually tagged ...
Podgornik Aleš A BIA Separations d.o.o., Mirce 21, 5270 Ajdovščina, Slovenia; COBIK, Tovarniška 26, 5270 Ajdovščina, Slovenia. Electronic address: - - 2014
Chromatographic monoliths have several interesting properties making them attractive supports for analytics but also for purification, especially of large biomolecules and bioassemblies. Although many of monolith features were thoroughly investigated, there is no data available to predict how monolith mechanical properties affect its chromatographic performance. In this work, we investigated ...
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