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Results 251 - 300 of 2137
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Xu Xijun - - 2013
Simultaneous removal of sulfide (S(2-)), nitrate (NO3(-)) and acetate (Ac(-)) under denitrifying sulfide removal process (DSR) is a novel biological wastewater treatment process. This work developed a mathematical model to describe the kinetic behavior of sulfur-nitrogen-carbon and interactions between autotrophic denitrifiers and heterotrophic denitrifiers. The kinetic parameters of the model ...
Hosseini S M - - 2013
Proteoglycan loss and surface roughening, early signs of osteoarthritis, are likely preceded by softening of the ground substance and the collagen network. Insight in their relative importance to progression of osteoarthritis may assist the development of treatment strategies for early osteoarthritis. To support interpretation of experimental data, a numerical model ...
Moore A C - - 2013
For nearly a century, articular cartilage has been known for its exceptional tribological properties. For nearly as long, there have been research efforts to elucidate the responsible mechanisms for application toward biomimetic bearing applications. It is now widely accepted that interstitial fluid pressurization is the primary mechanism responsible for the ...
Marsolier-Kergoat Marie-Claude - - 2013
Whereas GC-biased gene conversion (gBGC) following meiotic recombination seems the most probable mechanism accounting for large-scale variations in GC content for many eukaryotes, it cannot explain such variations for organisms belonging to ancient asexual lineages, like the pathogenic fungi Candida albicans and Candida dubliniensis. Analysis of the substitution patterns for ...
González González Nieves Luisa - - 2013
Abstract Objetives: To construct a model of customized birthweight curves for use in a Spanish population. Material and Method: Data of 20,331 newborns were used to construct a customized birthweight model. Multiple regression analysis was performed with newborn weight as the dependent variable and gestational age (GA), sex and maternal ...
Bultmann Christoph André - - 2013
Gene expression analysis by quantitative PCR is a standard laboratory technique for RNA quantification with high accuracy. In particular real-time PCR techniques using SYBR Green and melting curve analysis allowing verification of specific product amplification have become a well accepted laboratory technique for rapid and high throughput gene expression quantification. ...
Heredia-Ortiz Roberto - - 2013
3-Hydroxybenzo(a)pyrene (3-OHBaP) in urine has been proposed as a biomarker of occupational exposure to polycyclic aromatic hydrocarbons. However, to reconstruct exposure doses in workers from biomarker measurements, a thorough knowledge of the kinetics of the benzo(a)pyrene (BaP) and 3-OHBaP given different routes of exposure is needed. A rat physiologically-based pharmacokinetic ...
Skacel Pavel - - 2013
Several constitutive models have been proposed for the description of mechanical behaviour of soft tissues containing collagen fibres. Some of the commonly used approaches accounting for the dispersion of fibre orientations are based on the summation of (mechanical) contributions of differently oriented fibre families. This leads to the need of ...
Hope Bruce K BK CH2M HILL, Portland, Oregon, - - 2013
Mercury (Hg) has been entering the environment from both natural and anthropogenic sources for millennia, and humans have been influencing its environmental transport and fate from well before the Industrial Revolution. Exposure to Hg (as neurotoxic monomethylmercury [MeHg]) occurs primarily through consumption of finfish, shellfish, and marine mammals, and regulatory ...
Varadi Mihaly M VIB Department of Structural Biology, Vrije Universiteit Brussel, Brussels, European Molecular Biology Laboratory, Hamburg Unit, EMBL c/o DESY, Hamburg, Germany, CEA, CNRS, UJF-Grenoble 1, Protein Dynamics and Flexibility, Institut de Biologie Structurale Jean-Pierre Ebel, 41 Rue Jules Horowitz, Grenoble 38027, France, Indiana University School of Medicine; Indianapolis, IN, USA, Department of Chemistry, Center of Magnetic Resonance (CERM), University of Florence, Sesto Fiorentino, Italy, Molecular Structure and Function Program, Hospital for Sick Children, Toronto, Ontario, Canada, Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada, Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA, Department of Structural Biology, Weizmann Institute of Science, Rehovot 76100, Israel, Department of Molecular Medicine and USF Health Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Tampa, FL, USA, Institute for Biological Instrumentation, Russian Academy of Sciences, Pushchino, Moscow Region, Russia, Department of Chemistry, University of Cambridge, Cambridge, UK, Departments of Biological Sciences and Computing Science, University of Alberta, Edmonton, AB T6G 2E8, Canada, Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA Institute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, - - 2014
The goal of pE-DB (http://pedb.vib.be) is to serve as an openly accessible database for the deposition of structural ensembles of intrinsically disordered proteins (IDPs) and of denatured proteins based on nuclear magnetic resonance spectroscopy, small-angle X-ray scattering and other data measured in solution. Owing to the inherent flexibility of IDPs, ...
Landberg Tobias - - 2014
Egg size is a key life history trait affecting fitness, and it varies abundantly. The value of egg size to a mother and her offspring is often determined by a trade-off between investing more yolk in a few large eggs or less yolk into many more, smaller eggs. Smaller eggs ...
Wang Zhuo - - 2013
Biomechanical study of double-level pedicle screw constructs with or without crosslinks in an unstable model. The purpose of this study is to investigate the optimal position and orientation of the crosslink. Several reports have described biomechanical research on such crosslink, but no definite consensus has been reached regarding the effects. ...
Kostylev Maxim - - 2013
Lignocellulosic biomass is digested in nature by the synergistic activities of enzymes with complementary properties and understanding synergistic interactions will improve the efficiency of industrial biomass use for sustainable fuels and chemicals. TfCel9A and TfCel48A from a model bacterium Thermobifida fusca are two cellulases with different properties and have previously ...
Moffitt Jeffrey R JR Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, - - 2014
Enzyme-catalyzed reactions are naturally stochastic, and precision measurements of these fluctuations, made possible by single-molecule methods, promise to provide fundamentally new constraints on the possible mechanisms underlying these reactions. We review some aspects of statistical kinetics: a new field with the goal of extracting mechanistic information from statistical measures of ...
Pandey Abhishek A Department of Mathematical Sciences, Clemson University, Clemson, South Carolina 29634, USA. Electronic address: - - 2013
Various simple mathematical models have been used to investigate dengue transmission. Some of these models explicitly model the mosquito population, while others model the mosquitoes implicitly in the transmission term. We study the impact of modeling assumptions on the dynamics of dengue in Thailand by fitting dengue hemorrhagic fever (DHF) ...
Li Xiao-Mei - - 2013
Circadian timing of anticancer medications has improved treatment tolerability and efficacy several-fold, yet with inter-subject variability. Using three C57BL/6-based mouse strains of both sexes, we identified three chronotoxicity classes, with distinct circadian toxicity patterns of irinotecan, a topoisomerase I inhibitor active against colorectal cancer. Liver and colon circadian 24-h expression ...
Shao Qing-Song - - 2013
Rhizoma Atractylodis Macrocephalae (RAM) is a commonly used food and traditional Chinese medicine (TCM), which traditionally strengthens the spleen, benefits vital energy, eliminates dampness, and promotes hidroschesis. Its primary effective constituents are polysaccharides and volatile oil, whose main components are atractylenolide I and III. Fourier transform near-infrared spectroscopy (FT-NIR) is ...
Li Yi-Nan - - 2013
Refined oil mixtures can be quantified using terahertz-absorption-coefficient spectra and dualistic linear regression fitting. However, when this method was used to quantify mixtures of 90# and 97# gasolines, the absolute error between the real and fitted value was large (25%), and this was due to the component similarity between 90# ...
Lebert André A INRA, Centre Clermont-Ferrand/Theix, UR 370: Qualité des Produits Animaux, 63 122, St Genes Champanelle, France; Université Blaise Pascal, Institut Pascal UMR CNRS/UBP/IFMA 6602, France. Electronic address: - - 2013
New beef products from low value cuts could be developed using marinating since this process has been shown to improve meat sensorial properties and shelf life. However, to optimise the process mathematical models are needed to predict evolution of the physicochemical properties that determine biochemical and structural changes. Two major ...
Prunescu Remus Mihail - - 2013
The enzymatic hydrolysis process is one of the key steps in second generation biofuel production. After being thermally pretreated, the lignocellulosic material is liquefied by enzymes prior to fermentation. The scope of this paper is to evaluate a dynamic model of the hydrolysis process on a demonstration scale reactor. The ...
Yang Daibin - - 2013
Tebuconazole is a triazole systemic fungicide that is commonly used to treat fungal pathogens of crops, but at high doses can reduce seed germination. Seeds with microcapsulated tebuconazole were investigated to determine effects of this method on maize seedlings and the bioefficacy against maize head smut (Sphacelotheca reiliana). The ethyl ...
de Sales Priscila F - - 2013
The effect of acid treatment on natural agalmatolite (AN) and natural kaolinite (KN) was investigated, together with the influence of those modifications on the removal of Coomassie Blue (CB) dye. The process was optimized using the Response Surface Methodology (RSM) developed by the application of the quadratic model associated with ...
Akagi Yuki - - 2013
We have investigated the fracture behaviors of tetra-arm polyethylene glycol (Tetra-PEG) gels with controlled network structures. Tetra-PEG gels were prepared by AB-type crosslink-coupling of mutually reactive tetra-arm prepolymers with different concentrations and molecular weights. This series of controlled network structures, for the first time, enabled us to quantitatively examine the ...
van der Hoeven-Hangoor E - - 2013
High litter moisture content, often referred to as wet litter, is a major problem in poultry production. Wet litter is often related to poor management, diseases, and digestive problems. In this experiment, the objective was to study the relationship between nutrient content and the moisture content of the excreta of ...
Tarcsay Akos - - 2013
Formation of ligand-protein complexes requires simultaneous adaptation of the binding partners. In structure based virtual screening high throughput docking approaches typically consider the ligand flexibility but the conformational freedom of the protein is usually taken into account in limited way. The goal of this study is to elaborate a methodology ...
Staschen Carl-Michael - - 2013
Abstract Background: Allometric exponents in population pharmacokinetic analysis are regularly used but the issue of fixing or estimating an allometric exponent remains controversial. The objective of the current analysis is to evaluate the performance of a body-weight-dependent allometric exponent (BDE) model of remifentanil. Methods: The study was conducted in 34 ...
Chirwa Esnat D - - 2013
Abstract Background: Different structural and non-structural models have been used to describe human growth patterns. However, few studies have compared the fitness of these models in an African transitioning population. Aim: To find model(s) that best describe the growth pattern from birth to early childhood using mixed effect modelling. Subjects ...
Jenko J - - 2013
Survival analysis techniques for sire-maternal grandsire (MGS) and animal models were used to test the genetic evaluation of longevity in a Slovenian Brown cattle population characterized by small herds. Three genetic models were compared: a sire-MGS model for bulls and an approximate animal model based on estimated breeding values (EBV) ...
Ghaffari Noushin - - 2013
A key goal of systems biology and translational genomics is to utilize high-throughput measurements of cellular states to develop expression-based classifiers for discriminating among different phenotypes. Recent developments of Next Generation Sequencing (NGS) technologies can facilitate classifier design by providing expression measurements for tens of thousands of genes simultaneously via ...
Rohlfs Rori V - - 2013
Much of the phenotypic variation observed between even closely related species may be driven by differences in gene expression levels. The current availability of reliable techniques like RNA-Seq which can quantify expression levels across species has enabled comparative studies. Ornstein-Uhlenbeck (OU) processes have been proposed to model gene expression evolution ...
Deeb Omar - - 2013
Abstract Quantitative Structure-Activity Relationship (QSAR) models for binding affinity constants (log Ki) of 78 flavonoid ligands towards the benzodiazepine site of GABA (A) receptor complex were calculated using the machine learning methods: artificial neural network (ANN) and support vector machine (SVM) techniques. The models obtained were compared with those obtained ...
Underwood T L - - 2013
Differences in core level binding energies between atoms belonging to the same chemical species can be related to differences in their intra- and extra-atomic charge distributions, and differences in how their core holes are screened. With this in mind, we consider the charge-excess functional model (CEFM) for net atomic charges ...
Choi Minsung - - 2013
Arabic date is overproduced in Arabic countries such as Saudi Arabia and Iraq and is mostly composed of sugars (70-80 wt%). Here we developed a fed-batch fermentation process by using a kinetic model for the efficient production of lactic acid to a high concentration from Arabic date juice. First, a kinetic ...
Barkaoui Abdelwahed - - 2013
The complexity and heterogeneity of bone tissue require a multiscale modeling to understand its mechanical behavior and its remodeling mechanisms. In this paper, a novel multiscale hierarchical approach including microfibril scale based on hybrid neural network (NN) computation and homogenization equations was developed to link nanoscopic and macroscopic scales to ...
McCoy Airlie J - - 2013
A method is described for generating protein fragments suitable for use as molecular-replacement (MR) template models. The template model for a protein suspected to undergo a conformational change is perturbed along combinations of low-frequency normal modes of the elastic network model. The unperturbed structure is then compared with each perturbed ...
Belanche A - - 2013
Currently, rapid methods are needed for feed analysis. This study examined the potential of Fourier-transform infrared (FTIR) spectroscopy to predict the nutritional value of a wide range of feeds for ruminants, as an alternative to the in situ technique. Moreover, we investigated whether universal equations could be developed that would ...
Kloosterman Fabian - - 2013
A fundamental task in neuroscience is to understand how neural ensembles represent information. Population decoding is a useful tool to extract information from neuronal populations based on the ensemble spiking activity. We propose a novel Bayesian decoding paradigm to decode unsorted spikes in the rat hippocampus. Our approach uses a ...
Kashiwabara André Yoshiaki - - 2013
Discrete Markovian models can be used to characterize patterns in sequences of values and have many applications in biological sequence analysis, including gene prediction, CpG island detection, alignment, and protein profiling. We present ToPS, a computational framework that can be used to implement different applications in bioinformatics analysis by combining ...
Barbour April M - - 2013
The purpose of this report was to compare two different methods for dose optimisation of antimicrobials. The probability of target attainment (PTA) was calculated using Monte Carlo simulation to predict the PK/PD target of fT>MIC or modelling and simulation of time-kill curve data. Ceftobiprole, the paradigm compound, activity against two ...
Ding Chengxiang - - 2013
Many critical properties of the Hintermann-Merlini model are known exactly through the mapping to the eight-vertex model. Wu [J. Phys. C 8, 2262 (1975)] calculated the spontaneous magnetizations of the model on two sublattices by relating them to the conjectured spontaneous magnetization and polarization of the eight-vertex model, respectively. The ...
Beaty Lynne E - - 2013
Invasive species are costly and difficult to control. In order to gain a mechanistic understanding of potential control measures, individual-based models uniquely parameterized to reflect the salient life-history characteristics of invasive species are useful. Using invasive Australian Rhinella marina as a case study, we constructed a cohort- and individual-based population ...
Vinayak - - 2013
The Wishart model for real symmetric correlation matrices is defined as W=AA^{t}, where matrix A is usually a rectangular Gaussian random matrix and A^{t} is the transpose of A. Analogously, for nonsymmetric correlation matrices, a model may be defined for two statistically equivalent but different matrices A and B as ...
Jin Ick Hoon IH Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030-4009, - - 2013
Exponential random graph models have been widely used in social network analysis. However, these models are extremely difficult to handle from a statistical viewpoint, because of the intractable normalizing constant and model degeneracy. In this paper, we consider a fully Bayesian analysis for exponential random graph models using the adaptive ...
He Ran - - 2013
Low-rank matrix recovery algorithms aim to recover a corrupted low-rank matrix with sparse errors. However, corrupted errors may not be sparse in real-world problems and the relationship between L1 regularizer on noise and robust M-estimators is still unknown. This paper proposes a general robust framework for low-rank matrix recovery via ...
Hutsell Blake A - - 2013
Rats responded in a six-stimulus, two-response temporal classification procedure. A successive-reversal design was used in which the relationship between stimulus class (short vs. long) and correct comparison location (left or right) reversed every 15 sessions. After several reversals, the relative probability of reinforcement for each correct classification was manipulated across ...
Facchinetti Andrea - - 2013
Continuous glucose monitoring (CGM) sensors are portable devices, employed in the treatment of diabetes, able to measure glucose concentration in the interstitium almost continuously for several days. However, CGM sensors are not as accurate as standard blood glucose (BG) meters. Studies comparing CGM vs BG demonstrated that CGM is affected ...
Cattelan Manuela - - 2013
The study of the determinants of fights between animals is an important issue in understanding animal behavior. For this purpose, tournament experiments among a set of animals are often used by zoologists. The results of these tournament experiments are naturally analyzed by paired comparison models. Proper statistical analysis of these ...
David Ingrid - - 2013
The pre-weaning growth of lambs, an important component of meat production, depends on maternal and direct effects. These effects cannot be observed directly and models used to study pre-weaning growth assume that they are additive. However, it is reasonable to suggest that the influence of direct effects on growth may ...
Zhu Xi - - 2013
In this paper, robust control problem using μ-synthesis in microbial continuous culture is studied. The dissimilation process of glycerol to 1,3-propanediol cannot avoid the disturbances caused by uncertain factors. Based on the biodynamical model, a control system with the initial glycerol concentration as input control is proposed to simplify the controller ...
Muthukumar M - - 2013
A thermodynamic model is used to investigate the conditions under which clathrin triskelions form polyhedral baskets. The analysis, which is similar to classical methods used to study micelle formation, relates clathrin basket energetics to system parameters linked to triskelial rigidity, the natural curvature of an isolated triskelion, and interactions between ...
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