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Results 201 - 250 of 2425
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Bruch Joachim J IBE GmbH , Cologne , Germany - - 2014
Abstract Increased lung cancer incidence with workers at the production site of crude silicon carbide (SiC) using the Acheson process has been reported. Several agents derived from the process were discussed as causative factors. Recently concern had been expressed about the presence of cleavage fragments (CFs) in commercial products fulfilling ...
Hayes Ryan L RL Center for Theoretical Biological Physics and Department of Physics and Astronomy, Rice University, Houston, - - 2014
The stability of RNA tertiary structures depends heavily on Mg(2+). The Mg(2+)-RNA interaction free energy that stabilizes an RNA structure can be computed experimentally through fluorescence-based assays that measure Γ2+, the number of excess Mg(2+) associated with an RNA molecule. Previous explicit-solvent simulations predict that the majority of excess Mg(2+) ...
Bennewitz J J Institute of Animal Husbandry and Breeding, University of Hohenheim, 70593 Stuttgart, - - 2014
Feather pecking and aggressive pecking is a well-known problem in egg production. In the present study, genetic parameters for 4 feather-pecking-related traits were estimated using generalized linear mixed models. The traits were bouts of feather pecking delivered (FPD), bouts of feather pecking received (FPR), bouts of aggressive pecking delivered (APD), ...
Zhu Ying Y National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, Department of Biomedical Engineering, School of Medicine, Shenzhen University, Shenzhen 518160, China; Department of Electrical and Computer Engineering, St. Cloud State University, St. Cloud, MN 56301, - - 2014
The process of liver fibrosis changes the rheological properties of liver tissue. This study characterizes and compares liver fibrosis stages from F0 to F4 in rats in terms of shear viscoelastic moduli. Here two viscoelastic models, the Zener model and Voigt model, were applied to experimental data of rheometer tests ...
Proctor C J CJ MRC-Arthritis Research UK Centre for Integrated Research into Musculoskeletal Ageing and Newcastle University, Newcastle upon Tyne, - - 2014
To use a novel computational approach to examine the molecular pathways involved in cartilage breakdown and to use computer simulation to test possible interventions for reducing collagen release. We constructed a computational model of the relevant molecular pathways using the Systems Biology Markup Language, a computer-readable format of a biochemical ...
Chang Chun-Wei - - 2014
Existing individual size distribution (ISD) theories assume that the trophic level (TL) of an organism varies as a linear function of its log-transformed body size. This assumption predicts a power-law distribution of the ISD, i.e., a linear relationship between size and abundance in log space. However, the secondary structure of ...
DeGregorio Brett A BA Department of Natural Resources and Environmental Sciences, University of Illinois 1102 S. Goodwin Ave, Urbana, Illinois, - - 2014
1 Anthropogenic alteration of landscapes can affect avian nest success by influencing the abundance, distribution, and behavior of predators. Understanding avian nest predation risk necessitates understanding how landscapes affect predator distribution and behavior. 2 From a sample of 463 nests of 17 songbird species, we evaluated how landscape features (distance ...
Bull Richard R Radiation Dosimetry Department, Health Physics Division, Nuvia Limited, Harwell, Didcot, Oxfordshire OX11 0TQ, - - 2014
An intake of C14 in the form of dichlorobenzene was followed up with 90 spot urine samples over a period of almost 2 weeks. This dataset has been fitted by a model consisting of three exponential terms. The intake and effective dose have been calculated. This case has been used ...
Vicovaro Michele M University of Padova, Department of General Psychology, Italy. Electronic address: - - 2014
We studied the size-weight illusion through comparative judgments. The experiment had two direct aims: to verify whether the relative contribution of size to apparent heaviness can differ for different stimulus sets, and to verify whether that contribution can differ for different methods of comparing two objects (consecutive vs. simultaneous weighing). ...
González-Rodríguez A A Unidad de Genética Cuantitativa y Mejora Animal. Facultad de Veterinaria, Universidad de Zaragoza, C. Miguel Servet, 177, 50013 Zaragoza, - - 2014
One of the main goals of selection schemes in beef cattle populations is to increase carcass weight at slaughter. Live weights at different growth stages are frequently used as selection criteria under the hypothesis that they usually have a high and positive genetic correlation with weight at slaughter. However, the ...
Almagro Juan C JC CTI Boston, Pfizer - - 2014
To assess the state of the art in antibody 3D modeling, eleven unpublished high-resolution x-ray Fab crystal structures from diverse species and covering a wide range of antigen-binding site conformations were used as benchmark to compare Fv models generated by seven structure prediction methodologies. The participants included: Accerlys Inc, Chemical ...
Van Wittenberghe Shari S Department of Bioscience Engineering, Faculty of Sciences, University of Antwerp, Groenenborgerlaan 171, B-2020 Antwerpen, Belgium. Electronic address: - - 2014
Biochemical and structural leaf properties such as chlorophyll content (Chl), nitrogen content (N), leaf water content (LWC), and specific leaf area (SLA) have the benefit to be estimated through nondestructive spectral measurements. Current practices, however, mainly focus on a limited amount of wavelength bands while more information could be extracted ...
Sarwa Khomendra K KK Dibrugarh University, Department of Pharmaceutical Sciences , Dibrurarh, 786004 , India - - 2014
Objectives: Bhut Jolokia is a capsicum variety indigenous to Northeast India and is recognized as the hottest capsicum variety of the world. The ethnobotanical survey revealed that it has potential anti-arthritic activity but its topical adverse events restrict its usability. In the present study, the semipurified capsaicinoids extract of Bhut ...
Eilstein Joan J L'Oréal Research and Innovation, 1, Av. Eugene Schueller, 93601, Aulnay sous Bois Cedex, France, - - 2014
Skin function is not limited to a physical barrier. According to its total surface area, it is also considered as an extra-hepatic metabolizing organ. In vitro engineered human skins have been developed to replace limited ex vivo normal human skin samples (NHS). Thus, assessing and comparing skin models from SkinEthic ...
Sahota Tarjinder T Division of Pharmacology, Leiden Academic Centre for Drug Research, Leiden, The - - 2014
The assessment of safety in traditional toxicology protocols rely on evidence arising from observed adverse events (AEs) in animals and on establishing their correlation with different measures of drug exposure (e.g., Cmax and AUC). Such correlations, however, ignore the role of biomarkers, which can provide further insight into the underlying ...
Sivieri Katia K 1 Department of Food & Nutrition, Faculty of Pharmaceutical Sciences, São Paulo State University , Araraquara, São Paulo, Brazil - - 2014
Abstract Maintaining "gut health" is a goal for scientists throughout the world. Therefore, microbiota management models for testing probiotics, prebiotics, and synbiotics have been developed. The SHIME(®) model was used to study the effect of fructooligosaccharide (FOS) on the fermentation pattern of the colon microbiota. Initially, an inoculum prepared from ...
Pelletier Tara A TA Department of Evolution, Ecology, and Organismal Biology, The Ohio State University, 318 W. 12th Avenue, Columbus, OH, - - 2014
Model-based analyses are common in phylogeographic inference because they parameterize processes such as population division, gene flow and expansion that are of interest to biologists. Approximate Bayesian Computation is a model-based approach that can be customized to any empirical system and used to calculate the relative posterior probability of several ...
Abdalmula A A Faculty of Veterinary Science, University of Melbourne, Parkville, Victoria, - - 2014
Collagen induced arthritis (CIA) is the most studied and used rheumatoid arthritis (RA) model in animals, as it shares many pathological and immunological features of the human disease. The aim of this study was to characterize clinical and immunological aspects of the ovine CIA model, and develop lameness and histopathological ...
Xia Fei F School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive 637551, - - 2014
Elastic network models (ENM) are based on the idea that the geometry of a protein structure provides enough information for computing its fluctuations around its equilibrium conformation. This geometry is represented as an elastic network (EN) that is, a network of links between residues. A spring is associated with each ...
Liu Fei F The Key Lab of Drug Metabolism and Pharmacokinetics, Beijing Institute of Pharmacology and Toxicology, No. 27 Taiping Road, Beijing, 100850, PR China; Department of Pharmacy, the First Affiliated Hospital of PLA, No.51 Fucheng Road, Beijing, 10048, PR - - 2014
YQA-14 is a novel and selective dopamine D3 receptor antagonist, with potential for treatment of drug addiction. However, the earlier compounds in its structural class tend to have poor oral bioavailability. The objectives of this study were to characterize the preclinical absorption, distribution, metabolism, and excretion (ADME) properties and pharmacokinetics ...
van Ravenzwaay B B BASF SE, Ludwigshafen, Germany. Electronic address: - - 2014
The identification of the no observed adverse effect level (NOAEL) is the key regulatory outcome of toxicity studies. With the introduction of "omics" technologies into toxicological research, the question arises as to how sensitive these technologies are relative to classical regulatory toxicity parameters. BASF SE and metanomics developed the in ...
Johnston Marie M Institute of Applied Health Sciences, University of Aberdeen, - - 2014
In studies involving theoretical constructs, it is important that measures have good content validity and that there is not contamination of measures by content from other constructs. While reliability and construct validity are routinely reported, to date, there has not been a satisfactory, transparent, and systematic method of assessing and ...
Alipouri Yousef Y Faculty of Electrical Engineering, Iran University of Science and Technology, Tehran, - - 2014
The Minimum Variance Lower Bound (MVLB) represents the best achievable controller capability in a variance sense. Estimation and realization of MVLB for nonlinear systems confront some difficulties. Hence, almost all methods introduced so far estimate MVLB for a certain structure (e.g., NARMAX) or controller (e.g. PID). In this paper, MVLB ...
Kauppinen Ari A School of Pharmacy, Promis Centre, Faculty of Health Sciences, University of Eastern Finland, P.O. Box 1627, Kuopio FI-70211, Finland. Electronic address: - - 2014
This study assessed the validity of a multipoint near-infrared (NIR) spectroscopy method for in-line moisture content analysis during a freeze-drying process. It is known that the moisture content affects the stability of a freeze-dried product and hence it is a major critical quality attribute. Therefore assessment of the validity of ...
Teplyakov Alexey A Janssen Research & Development, LLC, 1400, McKean Road, Spring House, PA, 19477, - - 2014
To assess the state of the art in antibody structure modeling, a blinded study was conducted. Eleven unpublished Fab crystal structures were used as a benchmark to compare Fv models generated by 7 structure prediction methodologies. In the first round, each participant submitted 3 non-ranked complete Fv models for each ...
Carvalho-Lobato Patricia P 1 Human Anatomy and Embryology Unit, HUBc, University of Barcelona , Barcelona, - - 2014
Abstract Objective: This review attempts to organize the existing published literature regarding tooth movement in orthodontic treatment when low-level laser therapy (LLLT) is applied. Background data: The literature discusses different methods that have been developed to motivate the remodeling and decrease the duration of orthodontic treatment. The application of LLLT ...
Couture Raoul-Marie RM Norwegian Institute for Water Research, Gaustadalléen 21, 0349 Oslo, Norway. - - 2014
A model network comprising climate models, a hydrological model, a catchment-scale model for phosphorus biogeochemistry, and a lake thermodynamics and plankton dynamics model was used to simulate phosphorus loadings, total phosphorus and chlorophyll concentrations in Lake Vansjø, Southern Norway. The model network was automatically calibrated against time series of hydrological, ...
Rickard Rory F RF Academic Department of Military Surgery and Trauma, Royal Centre for Defence Medicine, Birmingham, United Kingdom; Department of Plastic Surgery, Derriford Hospital, Plymouth, United Kingdom; Division of Plastic, Reconstructive and Maxillofacial Surgery, Department of Surgery, University of Cape Town, Cape Town, South Africa. Electronic address: - - 2014
The use of fascial perforating vessels as recipients for microvascular composite tissue autotransplants has led to vessel diameter discrepancy becoming an increasingly common finding. Little evidence, however, is available to direct the choice of anastomotic technique where a discrepancy exists. We have been studying two methods of anastomosing arteries where ...
Bruyndonckx Robin R Interuniversity Institute for Biostatistics and Statistical Bioinformatics (I-BIOSTAT), University of Hasselt, Diepenbeek, - - 2014
To complement analyses of the linear trend and seasonal fluctuation of European outpatient antibiotic use expressed in defined daily doses (DDD) by analyses of data in packages, to assess the agreement between both measures and to study changes in the number of DDD per package over time. Data on outpatient ...
Boettcher H S HS Dyrlægerne Univet, Jernbanegade 10, 6650 Brørup, - - 2014
It is proposed that a softening of the suspensory tissue in the claw is involved in the development of lameness and claw lesions in cattle. A relatively small amount of research has been carried out to verify this theory. Research in this area would be simplified if mechanical testing of ...
Kogel Ulrike U Philip Morris International R&D, Philip Morris Research Laboratories GmbH, Fuggerstrasse 3, 51149 Cologne, Germany; Philip Morris International R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, 2000 Neuchâtel, Switzerland. Electronic address: - - 2014
Towards a systems toxicology-based risk assessment, we investigated molecular perturbations accompanying histopathological changes in a 28-day rat inhalation study combining transcriptomics with classical histopathology. We demonstrated reduced biological activity of a prototypic modified risk tobacco product (pMRTP) compared with the reference research cigarette 3R4F. Rats were exposed to filtered air ...
Mainali Dipak D Department of Chemistry, Iowa State University, 1605 Gilman Hall, Ames, IA 50011, United States of - - 2014
Near infrared (NIR) spectroscopy has been widely used for the determination of water content in a wide variety of samples. With few exceptions, all methods employ a calibration model developed and applicable for a single product. The current study describes a NIR method using a single, comprehensive calibration model to ...
Olechnovič Kliment K Institute of Biotechnology, Vilnius University, Graičiūno 8, Vilnius LT-02241, - - 2014
Growing interest in computational prediction of ribonucleic acid (RNA) three-dimensional structure has highlighted the need for reliable and meaningful methods to compare models and experimental structures. We present a structure superposition-free method to quantify both the local and global accuracy of RNA structural models with respect to the reference structure. ...
Toropova Alla P AP IRCCS - Istituto di Ricerche Farmacologiche Mario Negri, Milano, - - 2014
A series of 107 1-[(2-hydroxyethoxy)-methyl]-6-(phenylthio) thymine (HEPT) with anti-HIV-1 activity as a non-nucleoside reverse transcriptase inhibitor (NNRTI) has been studied. Monte Carlo method has been used as a tool to build up the quantitative structure-activity relationships (QSAR) for anti-HIV-1 activity. The QSAR models were calculated with the representation of the ...
Yesilada Erdem E Yeditepe University, Faculty of Pharmacy, 34755 Atasehir, Istanbul, Turkey. Electronic address: - - 2014
Sambucus ebulus L. has a very prominent place in Turkish folk medicine. Leaves of the plant are practiced externally to relieve rheumatic pain, to treat abscess, for wound healing and internally against hemorrhoids and stomachache. In a previous work, aqueous extract of the leaves was shown to possess potent antiulcerogenic ...
Beck Jeremy M - - 2014
The concepts of activity cliffs and matched molecular pairs (MMP) are recent paradigms for analysis of datasets to identify structural changes that may be used to modify the potency of lead molecules in drug discovery projects. Analysis of MMPs was recently demonstrated as a feasible technique for QSAR-modeling of prospective ...
Arnold Dirk V DV Faculty of Computer Science, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4R2. - - 2014
Abstract We study the behaviour of a (1, λ)-ES that handles constraints by resampling infeasible candidate solutions for linear optimization problems with a conically constrained feasible region. The analysis generalizes prior work in that no particular orientation of the cone relative to the gradient of the objective function is assumed. ...
Boonen Harrie C M HC Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100, Copenhagen, Denmark, - - 2014
The Göttingen minipig model of obesity is used in pre-clinical research to predict clinical outcome of new treatments for metabolic diseases. However, treatment effects often remain unnoticed when using single parameter statistical comparisons due to the small numbers of animals giving rise to large variation and insufficient statistical power. The ...
Boisnic Sylvie S GREDECO Research Association, Paris, France. 121 rue de la Pompe 75 116 Paris - - 2014
Background: More aging adults and the social acceptance of aesthetic treatments have increased the demand for minimally invasive aesthetic treatments. Skin resurfacing is very effective at improving aging symptoms, including wrinkles and skin imperfections. Following the negative effects of full skin resurfacing, in addition to a very long downtime, fractional ...
Tuukkanen Anne T AT EMBL Hamburg c/o DESY, Building 25A, Notkestraße 85, 22603, Hamburg, - - 2014
Small-angle x-ray scattering (SAXS) is a powerful technique to study weak interactions between proteins and their ligands (other proteins, DNA/RNA or small molecules) in solution. SAXS provides knowledge about the equilibrium state, the stoichiometry of binding, and association-dissociation processes. The measurements are conducted in solution environment which allows easy monitoring ...
Achary P Ganga Raju PG a Department of Chemistry, Institute of Technical Education and Research (ITER) , Siksha 'O' Anusandhan University , Bhubaneswar , Odisha - - - 2014
CORAL software has been used to build quantitative structure-activity relationships (QSARs) for the prediction of binding affinities (pEC50, i.e., minus decimal logarithm of the 50% effective concentration) of 35 potent inhibitors towards the voltage-gated potassium channel subunit Kv7.2. The pEC50 has been modelled using eight random splits, with the following ...
Weerasinghe N S NS School of Physiology and Pharmacology, University of Bristol, - - 2014
The UVB and heat rekindling (UVB/HR) model shows potential as a translatable inflammatory pain model. However, the occurrence of central sensitization in this model, a fundamental mechanism underlying chronic pain, has been debated. Face, construct and predictive validity are key requisites of animal models; electromyogram (EMG) recordings were utilized to ...
Cazer Casey L CL Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University , Ithaca, New - - 2014
Abstract Antimicrobial use in food animals may increase antimicrobial resistance in their enteric bacteria that can be transferred to human microbiome. Over 70% of U.S. beef feedlots use non-ionophore in-feed antimicrobials for animal disease control, treatment, or growth promotion. The fraction of feedlots feeding chlortetracycline (CTC), mostly for disease control ...
Naimi Ashley I AI From the aDepartment of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, QC, Canada; and bInstitut national de santé publique du Québec, and Research Centre of the University of Montreal Hospital Centre, Montreal, QC, - - 2014
: Inverse probability-weighted marginal structural models with binary exposures are common in epidemiology. Constructing inverse probability weights for a continuous exposure can be complicated by the presence of outliers, and the need to identify a parametric form for the exposure and account for nonconstant exposure variance. We explored the performance ...
Chen Ze-Qin ZQ College of Chemistry and Chemical Engineering, Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province, China West Normal University, Nanchong, 637002, People's Republic of China, - - 2014
Thymine glycol (Tg), a toxic oxidative DNA lesion, is preferentially removed by endonuclease III (Endo III). To investigate the glycosylase activity of Endo III, the N-glycoside transfer mechanism in deoxythymidine glycol (dTg) is examined in this theoretical study based on the BHandHLYP/6-311++G(d,p) level of theory. Two controversial mechanisms were characterized, ...
Zhou Hua H North Carolina State University, Raleigh, - - 2014
Modern technologies are producing a wealth of data with complex structures. For instance, in two-dimensional digital imaging, flow cytometry and electroencephalography, matrix-type covariates frequently arise when measurements are obtained for each combination of two underlying variables. To address scientific questions arising from those data, new regression methods that take matrices ...
Wang Eric X - - 2014
A method for probability density function (PDF) estimation using Bayesian mixtures of weighted gamma distributions, called the Dirichlet process gamma mixture model (DP-GaMM), is presented and applied to the analysis of a laser beam in turbulence. The problem is cast in a Bayesian setting, with the mixture model itself treated ...
Broms Kristin M - - 2014
Determining the range of a species and exploring species--habitat associations are central questions in ecology and can be answered by analyzing presence--absence data. Often, both the sampling of sites and the desired area of inference involve neighboring sites; thus, positive spatial autocorrelation between these sites is expected. Using survey data ...
Risse Sarah S University of Potsdam, Potsdam, - - 2014
Eye-movement experiments suggest that the perceptual span during reading is larger than the fixated word, asymmetric around the fixation position, and shrinks in size contingent on the foveal processing load. We used the SWIFT model of eye-movement control during reading to test these hypotheses and their implications under the assumption ...
Kawai Toru - - 2014
We propose a new metric for long-range transport potential (LRTP), GIF, based on source-receptor analyses, and evaluate the LRTP and persistence of a wide variety of chlorinated and brominated organic compounds using GIF and overall persistence (POV). We calculated GIF and POV using our global 3D dynamic multimedia model (FATE). ...
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