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Sewer Alain - - 2014
High-quality expression data are required to investigate the biological effects of microRNAs (miRNAs). The goal of this study was, first, to assess the quality of miRNA expression data based on microarray technologies and, second, to consolidate it by applying a novel normalization method. Indeed, because of significant differences in platform ...
King Thomas L TL Centre for Offshore Oil, Gas and Energy Research, Department of Fisheries and Oceans Canada, 1 Challenger Dr., Dartmouth, Nova Scotia B2Y 4A2, Canada. Electronic address: - - 2014
An economical alternative to conventional crudes, Canadian bitumen, harvested as a semi-liquid, is diluted with condensate to make it viable to transport by pipeline to coastal areas where it would be shipped by tankers to global markets. Not much is known about the fate of diluted bitumen (dilbit) when spilled ...
van Uhm Janneke Im - - 2014
Botulinum toxin A (BoNT-A) is a new treatment modality in various causes of bladder dysfunction; like neurogenic detrusor overactivity and overactive bladder. The best technique of administrating BoNT-A in patients is unknown. A validated in vitro model could be used to investigate newer intravesical administration techniques of BoNT-A. In this ...
Sharizli A A AA a Mechanical Department, Faculty of Engineering , University of Malaya , 50603 , Kuala Lumpur , - - 2014
Abstract Objective: The increase in number of fatalities caused by road accidents involving heavy vehicles every year has raised the level of concern and awareness on road safety in developing countries like Malaysia. Changes in the vehicle dynamics' characteristics such as gross vehicle weight, travel speed and vehicle classification will ...
Sales James J Department of Nutrition and Feeding of Farm Animals, Institute of Animal Science, Uhříněves, 104 00 Prague 10, Czech Republic. Electronic address: - - 2014
After an extensive literature search, meta-analytic techniques (fixed effect, random effects and hierarchical Bayesian models) were applied to numerically describe sizes and precision of effects caused by castration of intact rams on several performance, carcass and meat quality response variables. According to random effects models, rams presented greater (P<0.05) average ...
Zelmer Derek A DA University of South Carolina-Aiken, Assistant Professor, Department of Biology and Geology, University of South - - 2014
Abstract The tendency to attribute species-area relationships to "island biogeography" effectively bypasses the examination of specific mechanisms that act to structure parasite communities. Positive covariation between fish size and infrapopulation richness should not be examined within the typical extinction-based paradigm, but rather be addressed from the standpoint of differences in ...
Srinivasan Prakash P Department of Civil & Environmental Engineering, Faculty of Engineering, The University of Auckland, Private Bag 92019, Auckland, New - - 2014
Single first-order (SFO) kinetic model is often used to derive the dissipation endpoints of an organic chemical in soil. This model is used due to its simplicity and requirement by regulatory agencies. However, using the SFO model for all types of decay pattern could lead to under- or overestimation of ...
Sheng Shujing S Guangzhou Quality R & D Center of Traditional Chinese Medicine, Guangdong Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, PR China; Guangdong Zhongsheng Pharmaceutical Co., Ltd., Dongguan 523325, PR - - 2014
Fufang Xueshuantong (FXST) Capsule is developed on a traditional Chinese medicine remedy, with a four-herb formula of Panax notoginseng, Radix astragali, Salvia miltiorrhizae and Radix scrophulariaceae. It has been used for treatment of the clinic cardiovascular disease for many years. Due to its complexity of compositions and polypharmacological effects, it ...
Rataj Krzysztof - - 2014
Homology modeling is a reliable method of predicting the three-dimensional structures of proteins that lack NMR or X-ray crystallographic data. It employs the assumption, that a structural resemblance exists between closely related proteins. Despite the availability of many crystal structures of possible templates, only the closest ones are chosen for ...
Oliveira Júnior Gerson Antonio GA Grupo de Melhoramento Animal e Biotecnologia (GMAB), Faculdade de Zootecnia e Engenharia de Alimentos (FZEA), Universidade de São Paulo, Pirassununga, São Paulo, Brazil, - - 2014
The objective of this study was to evaluate the impact of including weaning management group (WMG) as an uncorrelated random effect in the genetic evaluation of postweaning traits. Data from 186,507 Nellore animals' sons to 1,734 sires and 75,016 cows were analyzed. Three single-trait models were studied. These models included ...
Malchiodi F F Department of Agronomy, Food, Natural Resources, Animals and Environment (DAFNAE), University of Padova, Viale dell'Università 16, 35020 Legnaro, - - 2014
The objective of the present study was to investigate how the crossbreeding of Holstein (HO) cows with bulls from Nordic and Alpine European breeds affect milk quality traits, traditional milk coagulation properties (MCP), and curd firmness modeling obtained from individual milk samples. A total of 506 individual milk samples were ...
Maiti Aniruddha - - 2014
In this work, a compact model for the negative bias temperature instability (NBTI) is developed by considering the interface-state generation and the hole-trapping mechanisms. This model shows accurate reproduction of the threshold voltage (Vth) degradations measured from samples fabricated with different dielectric materials as well as processes. Totally 8 model ...
Arnold Anne A Max Planck Institute of Molecular Plant - - 2014
Large-scale modeling of plant metabolism provides the possibility to compare and contrast different cellular and environmental scenarios with the ultimate aim of identifying the components underlying the respective plant behavior. The existing models of Arabidopsis thaliana (Arabidopsis) are top-down assembled whereby the starting point is the annotated genome, in particular, ...
Mohammadein S A SA Department of Mathematics, Faculty of Science, Tanta University, Tanta, Egypt. Electronic address: - - 2014
The concentration distribution around a growing nitrogen gas bubble in the blood and other bio tissues of divers who ascend to surface too quickly is obtained by Mohammadein and Mohamed model (2010) for variant and constant ambient pressure through the decompression process. In this paper, the growing of gas bubbles ...
Miller J David JD Department of Chemistry, Carleton University, Ottawa, - - 2014
Choi et al. (2014a) reported that the concentrations of ergosterol, 1-3, 1-6 β glucan and a measure of viable fungi in dust were not related to allergic disease. I am sure that they are correct. However, as expressed, the data cannot be related to exposure and further two of the measurements ...
Miri Amir K AK Department of Mechanical Engineering, McGill University, 817 Sherbrooke Street West, Montreal, Quebec, H3A 0C3, Canada, - - 2014
The extracellular matrix (ECM) of the vocal fold tissue consists primarily of fibrous and interstitial proteins. The purpose of this study was to investigate the effects of selective enzymatic digestion of two ECM proteins, namely elastin and versican, on the elasticity of rabbit vocal fold tissue. Quasi-static, sinusoidal, uniaxial tensile ...
Rao Shodhan - - 2014
In this paper we propose a model reduction method for biochemical reaction networks governed by avariety of reversible and irreversible enzyme kinetic rate laws, including reversible Michaelis-Mentenand Hill kinetics. The method proceeds by a stepwise reduction in the number of complexes, definedas the left and right-hand sides of the reactions ...
Xiu Yun Y Institute of Life Science, Chongqing Medical University, Chongqing, People's Republic of China; Department of Histology and Embryology, Chongqing Medical University, Chongqing, People's Republic of - - 2014
The etiology of schizophrenia (SZ) is complex and largely unknown. Neuroimaging and postmortem studies have suggested white matter disturbances in SZ. In the present study, we tested the white matter deficits hypothesis of SZ using a mouse model of SZ induced by NMDA receptor antagonist MK-801. We found that mice ...
Childers W Lee WL Department of Prosthetics and Orthotics, Montgomery College of Health Sciences, Alabama State University, Montgomery, - - 2014
The individual pursuit is a 4km cycling time trial performed on a velodrome. Parathletes with transtibial amputation (TTA) have lost physiological systems but this may be offset by the reduced aerodynamic drag of the prosthesis. This research was performed to understand the effect of a uni-lateral transtibial amputation on Olympic ...
Aksoy Ozan O Department of Sociology & Nuffield Centre for Experimental Social Sciences, University of Oxford, Nuffield College, New Road, OX1 1NF Oxford, UK. Electronic address: - - 2014
In this paper, using a within-subjects design, we estimate the utility weights that subjects attach to the outcome of their interaction partners in four decision situations: (1) binary Dictator Games (DG), second player's role in the sequential Prisoner's Dilemma (PD) after the first player (2) cooperated and (3) defected, and ...
Junker Johan P E JP Division of Plastic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, - - 2014
The process of wound healing is dynamic and takes place over months to years, during which there is a resolution of angiogenesis, continued wound contraction, and connective tissue remodeling. The outcome of this process is most commonly the formation of a scar, defined as a fibrous tissue replacing normal tissues ...
Favorito Luciano A LA Urogenital Research Unit - State University from Rio de Janeiro - UERJ, RJ, - - 2014
Models for investigation in Urology: Rats, Pigs and Dogs. Importance of basic research in penile reconstruction and bladder overactivity. The May-June 2014 issue of the International Braz J Urol presents original contributions with a lot papers in different fields. The papers come from many different countries such as Brazil, USA, ...
Alloul-Ramdhani Mariam M Department of Dermatology, Leiden University Medical Center, Leiden, The - - 2014
Animal testing of chemical ingredients for cosmetic purposes is prohibited. Therefore there is an urgent need for in vitro models to identify chemical allergens. In human skin, keratinocytes (KCs) are abundantly present and are key players in initiation of allergic contact dermatitis. One of the pathways that has been shown ...
Tanoshima Reo R Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, University of Toronto, Toronto, Ontario, - - 2014
Population pharmacokinetic (pop PK) modeling can be used for PK assessment of drug in breast milk. However, complex mechanistic modeling of a parent and an active metabolite using both blood and milk samples is challenging. We aimed to develop a simple predictive pop PK model for milk concentration-time profiles of ...
Berrondo Monica M Macromoltek, LLC, 103 Parkwood Ct, Austin, TX, - - 2014
This study was a part of the Second Antibody Modeling Assessment (AMA-II). The assessment is a blind study of the performance of multiple software programs used for antibody homology modeling. In the study, research groups were given sequences for 11 antibodies and asked to predict their corresponding structures. The results ...
Osman Erkan Y EY Department of Molecular Microbiology and Immunology, School of Medicine, University of Missouri, Columbia, MO, 65211, - - 2014
Spinal muscular atrophy (SMA) is a neurodegenerative disease caused by the loss of Survival Motor Neuron-1 (SMN1). In all SMA patients a nearly identical copy gene called SMN2 is present which produces low levels of functional protein due to an alternative splicing event. To prevent exon-skipping, we have targeted an ...
Rodriguez-Martinez E - - 2014
This paper proposes a novel way for generating reliable low-dimensional features with improved class separability in a kernel-induced feature space. The feature projections rely on a very efficient sequential projection pursuit method, adapted to support nonlinear projections using a new kernel matrix update scheme. This enables the gradual removal of ...
Biasini Marco M Biozentrum, University of Basel, Basel 4056, Switzerland SIB Swiss Institute of Bioinformatics, Basel 4056, - - 2014
Protein structure homology modelling has become a routine technique to generate 3D models for proteins when experimental structures are not available. Fully automated servers such as SWISS-MODEL with user-friendly web interfaces generate reliable models without the need for complex software packages or downloading large databases. Here, we describe the latest ...
Zou Xin - - 2014
We propose a novel statistical approach to improve the reliability of 1H NMR spectral analysis in complex metabolic studies. The Statistical HOmogeneous Cluster SpectroscopY (SHOCSY) algorithm aims to reduce the variation within biological classes by selecting subsets of homogenous 1H NMR spectra that contain specific spectroscopic metabolic signatures related to ...
Bieser J J Institute of Coastal Research, Helmholtz-Zentrum Geesthacht, Max-Planck-Str. 1, 21502, Geesthacht, Germany, - - 2014
This study is part of the Global Mercury Observation System (GMOS), a European FP7 project dedicated to the improvement and validation of mercury models to assist in establishing a global monitoring network and to support political decisions. One key question about the global mercury cycle is the efficiency of its ...
Guo Lei L 1 National Key Laboratory of Cognitive Neuroscience and - - 2014
Summary.-An attribute weight calculation method which used a Bayesian network and the least squares distance method was proposed to assign different weights to different attributes in cognitive diagnosis. This method is independent of any specific cognitive diagnostic models, so it is practicable to consider attribute weight not only in the ...
Buchholcz Gyula G Bajai Szent Rókus Hospital , Baja , Hungary - - 2014
Abstract The focus of this work was to produce modified-release monolithic matrix tablets containing sodium riboflavin 5'-phosphate (vitamin B2) as active pharmaceutical ingredient (API). Riboflavin 5'-phosphate is absorbed from the upper gastrointestinal tract by a specific transport mechanism. The aim of this work was the development of modified-release tablets from ...
Cheheltani Rabee R Department of Mechanical Engineering, Temple University, Philadelphia, PA 19122, - - 2014
Extracellular matrix (ECM) is a key component and regulator of many biological tissues including aorta. Several aortic pathologies are associated with significant changes in the composition of the matrix, especially in the content, quality and type of aortic structural proteins, collagen and elastin. The purpose of this study was to ...
Alemozaffar Mehrdad M Beth Israel Deaconess Medical Center, Urology, 330 brookline Ave, Boston, Massachusetts, United States, 02215 ; - - 2014
Objective: To create a tissue-based simulator that allows practice of key steps of RARP in a sequential fashion. Materials and Methods: A model was created from female porcine genitourinary tract tissue to represent the male pelvic genitourinary anatomy. The following steps of RARP were simulated: DVC ligation, division of bladder ...
Lin Chen C Agronomy Department, Key Laboratory of Crop Germplasm Resource of Zhejiang Province, Zhejiang University, Hangzhou 310058, - - 2014
Grain protein content (GPC) is an important quality determinant in barley. This research aimed to explore the relationship between GPC and diffuse reflectance spectra in barley. The results indicate that normalizing, and taking first-order derivatives can improve the class models by enhancing signal-to-noise ratio, reducing baseline and background shifts. The ...
Palacios-Morillo Ana A Department of Analytical Chemistry, University of Seville, c/ Profesor García González 1, E-41012 Seville, - - 2014
A multielemental analytical method has been proposed to determine the contents of Al, B, Ca, Cu, Fe, K, Mg, Mn, Na, Ni, P, Pb, Sr and Zn in paprika samples from the two Protected Designations of Origin recognized in Spain, such as Murcia and La Vera (Extremadura). The samples are ...
Rivoire Olivier O Laboratoire Interdisciplinaire de Physique, Université Grenoble Alpes, F-38000 Grenoble, France;Laboratoire Interdisciplinaire de Physique, Centre National de la Recherche Scientifique, F-38000 Grenoble, France; - - 2014
The inheritance of characteristics induced by the environment has often been opposed to the theory of evolution by natural selection. However, although evolution by natural selection requires new heritable traits to be produced and transmitted, it does not prescribe, per se, the mechanisms by which this is operated. The mechanisms ...
Hoyle Rick H RH Department of Psychology and Neuroscience, Duke University, Durham, NC, 27708, USA, - - 2014
When the goal of prevention research is to capture in statistical models some measure of the dynamic complexity in structures and processes implicated in problem behavior and its prevention, approaches such as multilevel modeling (MLM) and structural equation modeling (SEM) are indicated. Yet the assumptions that must be satisfied if ...
Seven Ibrahim I From Cole Eye Institute (Seven, Sinha Roy, Dupps), Ocular Biomechanics and Imaging Laboratory, and the Department of Biomedical Engineering (Seven, Dupps), Lerner Research Institute, Cleveland Clinic, and the Department of Chemical and Biomedical Engineering (Seven), Cleveland State University, Cleveland, Ohio, USA; Narayana Netralaya (Sinha Roy), Bangalore, - - 2014
To test the hypothesis that spatially selective corneal stromal stiffening can alter corneal astigmatism and assess the effects of treatment orientation, pattern, and material model complexity in computational models using patient-specific geometries. Cornea and Refractive Surgery Service, Academic Eye Institute, Cleveland, Ohio, USA. Computational modeling study. Three-dimensional corneal geometries from ...
Graf Alexandra C AC Center for Medical Statistics, Informatics and Intelligent Systems, Medical University of Vienna, Spitalgasse 23, 1090, Vienna, Austria; Competence Center for Clinical Trials, University of Bremen, Linzer Strasse 4, 28359, Bremen, - - 2014
Sample size modifications in the interim analyses of an adaptive design can inflate the type 1 error rate, if test statistics and critical boundaries are used in the final analysis as if no modification had been made. While this is already true for designs with an overall change of the ...
Shirai Hiroki H Molecular Medicine Research laboratories, Drug Discovery Research, Astellas Pharma Inc., 21, Miyukigaoka, Tsukuba-shi, Ibaraki, 305-8585, - - 2014
In the second antibody modeling assessment (AMA-II), we used a semi-automated template-based structure modeling approach for 11 blinded antibody variable region (Fv) targets. The structural modeling method involved several steps, including template selection for framework and canonical structures of complementary determining regions (CDRs), homology modeling, energy minimization and expert inspection. ...
Potter-Baker Kelsey A KA Department of Biomedical Engineering, Case Western Reserve University, 2071 Martin Luther King Jr. Drive, Wickenden Bldg., Cleveland, OH 44106, USA; Advanced Platform Technology Center, L. Stokes Cleveland VA Medical Center, 10701 East Blvd. Mail Stop 151 AW/APT, Cleveland, OH 44106-1702, - - 2014
Rat models have emerged as a common tool to study neuroinflammation to intracortical microelectrodes. While a number of studies have attempted to understand the factors resulting in neuroinflammation using rat models, a complete understanding of key mechanistic pathways remains elusive. Transgenic mouse models, however, could facilitate a deeper understanding of ...
Klineberg E E Department of Orthopaedic Surgery, University of California Davis School of Medicine, 4860 Y St, Suite 3800, Sacramento, CA, 95817, USA, - - 2014
Noggin protein levels and spinal fusion rates were compared in a rabbit model after application of siRNA against BMP antagonist noggin in paraspinal muscle. To test whether endogenous BMPs are sufficient to form bone in the absence of their antagonists, using noggin siRNA to interrupt the negative feedback loop on ...
Madas Balázs G BG Environmental Physics Department, Centre for Energy Research, Hungarian Academy of Sciences, Konkoly-Thege Miklós út 29-33, Budapest 1121, - - 2014
There is a considerable debate between research groups applying the two-stage clonal expansion model for lung cancer risk estimation, whether radon exposure affects initiation and transformation or promotion. The aim of the present study is to quantify the effects of radon progeny on these stages with biophysical models. For this ...
Li W B WB HMGU-Research Unit Medical Radiation Physics and Diagnostics, Helmholtz Zentrum München - German Research Center for Environmental Health (GmbH), Neuherberg D-85764, - - 2014
Parameter uncertainties for the biokinetic model of caesium (Cs) developed by Leggett et al. were inventoried and evaluated. The methods of parameter uncertainty analysis were used to assess the uncertainties of model predictions with the assumptions of model parameter uncertainties and distributions. Furthermore, the importance of individual model parameters was ...
Rice Greggory M GM Department of Chemistry, University of North Carolina, Chapel Hill, North Carolina 27599-3290, - - 2014
RNA secondary structure modeling is a challenging problem, and recent successes have raised the standards for accuracy, consistency, and tractability. Large increases in accuracy have been achieved by including data on reactivity toward chemical probes: Incorporation of 1M7 SHAPE reactivity data into an mfold-class algorithm results in median accuracies for ...
Scott Ian M IM Institute of Biological, Environmental and Rural Sciences, Aberystwyth University, SY23 3DA, - - 2014
In chilling conditions (5°C), salicylic acid (SA)-deficient mutants (sid2, eds5, NahG) of Arabidopsis thaliana produced more biomass than wild-type (Col-0), while the SA-overproducer cpr1 was extremely stunted. The hypothesis that these phenotypes were reflected in metabolism was explored using 600 MHz 1H NMR analysis of unfractionated polar shoot extracts. Biomass-related ...
Yata Vinod Kumar VK a Department of Biotechnology , Dr B R Ambedkar National Institute of Technology Jalandhar , Jalandhar - 144 011 , - - 2014
Abstract Urease (EC 3.5.1.5., urea amidohydrolase) catalyzes the hydrolysis of urea to ammonia and carbon dioxide. Urease is present to a greater abundance in plants and plays significant role related to nitrogen recycling from urea. But little is known about the structure and function of the urease derived from the ...
Baveco J M Hans JM Alterra, Wageningen University and Research centre, Wageningen, The - - 2014
Population models, in particular individual-based models (IBM), are becoming increasingly important in chemical risk assessment. They can be used to assess recovery of spatially structured populations after chemical exposure that varies in time and space. We used an IBM coupled to a toxicokinetic-toxicodynamic model, the threshold damage model (TDM), to ...
Li Xinlei X MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, People's Republic of - - 2014
Studying the properties of nanomaterials can help us to understand the nature of the particular behavior of small-scale materials and forecast new advanced functionalized materials. The cohesive energy, as one of the most important fundamental properties, is strongly connected to the unique properties of nanostructures. In this work, we establish ...
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