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Scott Ian M IM Institute of Biological, Environmental and Rural Sciences, Aberystwyth University, SY23 3DA, - - 2014
In chilling conditions (5°C), salicylic acid (SA)-deficient mutants (sid2, eds5, NahG) of Arabidopsis thaliana produced more biomass than wild-type (Col-0), while the SA-overproducer cpr1 was extremely stunted. The hypothesis that these phenotypes were reflected in metabolism was explored using 600 MHz 1H NMR analysis of unfractionated polar shoot extracts. Biomass-related ...
Yata Vinod Kumar VK a Department of Biotechnology , Dr B R Ambedkar National Institute of Technology Jalandhar , Jalandhar - 144 011 , - - 2014
Abstract Urease (EC 3.5.1.5., urea amidohydrolase) catalyzes the hydrolysis of urea to ammonia and carbon dioxide. Urease is present to a greater abundance in plants and plays significant role related to nitrogen recycling from urea. But little is known about the structure and function of the urease derived from the ...
Baveco J M Hans JM Alterra, Wageningen University and Research centre, Wageningen, The - - 2014
Population models, in particular individual-based models (IBM), are becoming increasingly important in chemical risk assessment. They can be used to assess recovery of spatially structured populations after chemical exposure that varies in time and space. We used an IBM coupled to a toxicokinetic-toxicodynamic model, the threshold damage model (TDM), to ...
Li Xinlei X MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, People's Republic of - - 2014
Studying the properties of nanomaterials can help us to understand the nature of the particular behavior of small-scale materials and forecast new advanced functionalized materials. The cohesive energy, as one of the most important fundamental properties, is strongly connected to the unique properties of nanostructures. In this work, we establish ...
Cao Renzhi - - 2014
Protein model quality assessment is an essential component of generating and using protein structural models. During the Tenth Critical Assessment of Techniques for Protein Structure Prediction (CASP10), we developed and tested four automated methods (MULTICOM-REFINE, MULTICOM-CLUSTER, MULTICOM-NOVEL, and MULTICOM-CONSTRUCT) that predicted both local and global quality of protein structural models. ...
García-Gómez H H Atmospheric Pollution Division, CIEMAT, Av. Complutense 40, Madrid 28040, Spain. Electronic address: - - 2014
The Mediterranean Basin presents an extraordinary biological richness but very little information is available on the threat that air pollution, and in particular reactive nitrogen (N), can pose to biodiversity and ecosystem functioning. This study represents the first approach to assess the risk of N enrichment effects on Spanish ecosystems. ...
Brewin James J Kings Health Partners, Guy's Kings and St Thomas' NHS Foundation Trust, London, UK. Electronic address: - - 2014
Validation studies are an important part of simulator evaluation and are considered necessary to establish the effectiveness of simulation-based training. The widely used Bristol transurethral resection of prostate (TURP) simulator has not been formally validated. Evaluation of the face, content, and construct validities of the Bristol TURP simulator as an ...
Plomp Gijs G Functional Brain Mapping Laboratory, Department of Fundamental Neuroscience, University of Geneva, Geneva, Switzerland. Electronic address: - - 2014
Time-varying connectivity methods are increasingly used to study directed interactions between brain regions from electrophysiological signals. These methods often show good results in simulated data but it is unclear to what extent connectivity results obtained from real data are physiologically plausible. Here we introduce a benchmark approach using multichannel somatosensory ...
Park Robert M RM U.S. National Institute for Occupational Safety and Health, Cincinnati, USA. Electronic address: - - 2014
The appropriate exposure metrics for characterizing manganese (Mn) exposure associated with neurobehavioral effects have not been established. Blood levels of Mn (B-Mn) provide a potentially important intermediate marker of Mn airborne exposures. Using data from a study of a population of silicon- and ferro-manganese alloy production workers employed between 1973 ...
Rubert Nicholas N Department of Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin, USA. Electronic address: - - 2014
Attenuation estimation and imaging have the potential to be a valuable tool for tissue characterization, particularly for indicating the extent of thermal ablation therapy in the liver. Often the performance of attenuation estimation algorithms is characterized with numerical simulations or tissue-mimicking phantoms containing a high scatterer number density (SND). This ...
Maliqueo Manuel M Department of Physiology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, - - 2014
This review focuses on rodent models exposed to sex steroids prepubertally and describes their phenotypes and pathophysiology with specific focus on the estradiol valerate-, dihydrotestosterone-, and letrozole-induced rat polycystic ovary syndrome (PCOS) models. Phenotypic presentations are compared among models as a function of the timing and dose of the exposure. ...
Porcellato D D Department of Chemistry, Biotechnology and Food Science, Norwegian University of Life Science, P.O. Box 5003, N-1432, Aas, - - 2014
The structure and dynamics of microbial populations play a significant role during cheese manufacture and ripening. Therefore, fast and accurate methods for identification and characterization of the microbial populations are of fundamental importance to the cheese industry. In this study we investigate the application of the automated ribosomal intergenic spacer ...
Dieudonné Mutangana M a Jain University , Centre for Post Graduate Studies', Department of Biotechnology , 18/3, 9th Main, Jayanagar 3rd Block, Bangalore 560 011 , INDIA - - 2014
Abstract Melanocortin system is composed of four peptide hormones namely α-, β-, -γ and adrenocorticotropic hormone (ACTH), derived from post-translational cleavage of a polypeptide precursor 'proopiomelanocortin (POMC)'. Among these hormones, ACTH, a 38 amino acid residue peptide fragment is an important hormone as it is involved in steroid secretion. In ...
Lopes Fabio Marcellus FM Department of Mathematics, Stockholm University, SE-106 91, Stockholm, Sweden. Electronic address: - - 2014
We propose a weighted version of the standard configuration model which allows for a tunable degree-degree correlation. A social network is modeled by a weighted graph generated by this model, where the edge weights indicate the intensity or type of contact between the individuals. An inhomogeneous Reed-Frost epidemic model is ...
Chaudhuri Sutapa S Department of Atmospheric Sciences, University of Calcutta, 51/2, Hazra Road, Kolkata, 700019, India, - - 2014
The purpose of the present research is to identify the trends in the concentrations of few atmospheric pollutants and meteorological parameters over an urban station Kolkata (22° 32' N; 88° 20' E), India, during the period from 2002 to 2011 and subsequently develop models for precise forecast of the concentration ...
Ahmed Osama Aa OA King Abdulaziz University, Department of Pharmaceutics & Industrial Pharmacy, Faculty of Pharmacy , Jeddah-21589 , Saudi Arabia +966 599120686 ; +966 26951696 ; oaahmed@kau.edu.sa , - - 2014
Objectives: To optimize and use of glimepiride (GMD)-loaded self-nanoemulsifying delivery systems (SNEDs) for the preparation of transdermal patches. Methods: Mixture design was utilized to optimize GMD-loaded SNEDs in acidic and aqueous pH media. Optimized GMD-loaded SNEDs were used in the preparation of chitosan (acidic) and hydroxypropyl methyl cellulose (HPMC) (aqueous) ...
Carrasquer C A CA a James Graham Brown Cancer Center, University of Louisville , Louisville , KY , - - 2014
We previously demonstrated that fragment based cat-SAR carcinogenesis models consisting solely of mutagenic or non-mutagenic carcinogens varied greatly in terms of their predictive accuracy. This led us to investigate how well the rat cancer cat-SAR model predicted mutagens and non-mutagens in their learning set. Four rat cancer cat-SAR models were ...
Wahl Patrick R PR Research Center Pharmaceutical Engineering GmbH, Inffeldgasse 13/2, 8010 Graz, - - 2014
This paper describes the application and implementation of inline NIR spectroscopy in an industrial tablet press. The content uniformity of a powder was analyzed via a NIR probe mounted on the feed frame. A PLS model with four latent variables (R(2)= 0.97, Q(2)=0.95) was developed for the active pharmaceutical ingredient ...
Rollin Michael D H - - 2014
Animal models of human disease play a central role in modern biomedical science. Developing animal models for human mental illness presents unique practical and philosophical challenges. In this article we argue that (1) existing animal models of psychiatric disease are not valid, (2) attempts to model syndromes are undermined by ...
Bruch Joachim J IBE GmbH , Cologne , Germany - - 2014
Abstract Increased lung cancer incidence with workers at the production site of crude silicon carbide (SiC) using the Acheson process has been reported. Several agents derived from the process were discussed as causative factors. Recently concern had been expressed about the presence of cleavage fragments (CFs) in commercial products fulfilling ...
Hayes Ryan L RL Center for Theoretical Biological Physics and Department of Physics and Astronomy, Rice University, Houston, - - 2014
The stability of RNA tertiary structures depends heavily on Mg(2+). The Mg(2+)-RNA interaction free energy that stabilizes an RNA structure can be computed experimentally through fluorescence-based assays that measure Γ2+, the number of excess Mg(2+) associated with an RNA molecule. Previous explicit-solvent simulations predict that the majority of excess Mg(2+) ...
Bennewitz J J Institute of Animal Husbandry and Breeding, University of Hohenheim, 70593 Stuttgart, - - 2014
Feather pecking and aggressive pecking is a well-known problem in egg production. In the present study, genetic parameters for 4 feather-pecking-related traits were estimated using generalized linear mixed models. The traits were bouts of feather pecking delivered (FPD), bouts of feather pecking received (FPR), bouts of aggressive pecking delivered (APD), ...
Zhu Ying Y National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, Department of Biomedical Engineering, School of Medicine, Shenzhen University, Shenzhen 518160, China; Department of Electrical and Computer Engineering, St. Cloud State University, St. Cloud, MN 56301, - - 2014
The process of liver fibrosis changes the rheological properties of liver tissue. This study characterizes and compares liver fibrosis stages from F0 to F4 in rats in terms of shear viscoelastic moduli. Here two viscoelastic models, the Zener model and Voigt model, were applied to experimental data of rheometer tests ...
Proctor C J CJ MRC-Arthritis Research UK Centre for Integrated Research into Musculoskeletal Ageing and Newcastle University, Newcastle upon Tyne, - - 2014
To use a novel computational approach to examine the molecular pathways involved in cartilage breakdown and to use computer simulation to test possible interventions for reducing collagen release. We constructed a computational model of the relevant molecular pathways using the Systems Biology Markup Language, a computer-readable format of a biochemical ...
Chang Chun-Wei - - 2014
Existing individual size distribution (ISD) theories assume that the trophic level (TL) of an organism varies as a linear function of its log-transformed body size. This assumption predicts a power-law distribution of the ISD, i.e., a linear relationship between size and abundance in log space. However, the secondary structure of ...
DeGregorio Brett A BA Department of Natural Resources and Environmental Sciences, University of Illinois 1102 S. Goodwin Ave, Urbana, Illinois, - - 2014
1 Anthropogenic alteration of landscapes can affect avian nest success by influencing the abundance, distribution, and behavior of predators. Understanding avian nest predation risk necessitates understanding how landscapes affect predator distribution and behavior. 2 From a sample of 463 nests of 17 songbird species, we evaluated how landscape features (distance ...
Bull Richard R Radiation Dosimetry Department, Health Physics Division, Nuvia Limited, Harwell, Didcot, Oxfordshire OX11 0TQ, - - 2014
An intake of C14 in the form of dichlorobenzene was followed up with 90 spot urine samples over a period of almost 2 weeks. This dataset has been fitted by a model consisting of three exponential terms. The intake and effective dose have been calculated. This case has been used ...
Vicovaro Michele M University of Padova, Department of General Psychology, Italy. Electronic address: - - 2014
We studied the size-weight illusion through comparative judgments. The experiment had two direct aims: to verify whether the relative contribution of size to apparent heaviness can differ for different stimulus sets, and to verify whether that contribution can differ for different methods of comparing two objects (consecutive vs. simultaneous weighing). ...
González-Rodríguez A A Unidad de Genética Cuantitativa y Mejora Animal. Facultad de Veterinaria, Universidad de Zaragoza, C. Miguel Servet, 177, 50013 Zaragoza, - - 2014
One of the main goals of selection schemes in beef cattle populations is to increase carcass weight at slaughter. Live weights at different growth stages are frequently used as selection criteria under the hypothesis that they usually have a high and positive genetic correlation with weight at slaughter. However, the ...
Almagro Juan C JC CTI Boston, Pfizer - - 2014
To assess the state of the art in antibody 3D modeling, eleven unpublished high-resolution x-ray Fab crystal structures from diverse species and covering a wide range of antigen-binding site conformations were used as benchmark to compare Fv models generated by seven structure prediction methodologies. The participants included: Accerlys Inc, Chemical ...
Van Wittenberghe Shari S Department of Bioscience Engineering, Faculty of Sciences, University of Antwerp, Groenenborgerlaan 171, B-2020 Antwerpen, Belgium. Electronic address: - - 2014
Biochemical and structural leaf properties such as chlorophyll content (Chl), nitrogen content (N), leaf water content (LWC), and specific leaf area (SLA) have the benefit to be estimated through nondestructive spectral measurements. Current practices, however, mainly focus on a limited amount of wavelength bands while more information could be extracted ...
Sarwa Khomendra K KK Dibrugarh University, Department of Pharmaceutical Sciences , Dibrurarh, 786004 , India - - 2014
Objectives: Bhut Jolokia is a capsicum variety indigenous to Northeast India and is recognized as the hottest capsicum variety of the world. The ethnobotanical survey revealed that it has potential anti-arthritic activity but its topical adverse events restrict its usability. In the present study, the semipurified capsaicinoids extract of Bhut ...
Eilstein Joan J L'Oréal Research and Innovation, 1, Av. Eugene Schueller, 93601, Aulnay sous Bois Cedex, France, - - 2014
Skin function is not limited to a physical barrier. According to its total surface area, it is also considered as an extra-hepatic metabolizing organ. In vitro engineered human skins have been developed to replace limited ex vivo normal human skin samples (NHS). Thus, assessing and comparing skin models from SkinEthic ...
Sahota Tarjinder T Division of Pharmacology, Leiden Academic Centre for Drug Research, Leiden, The - - 2014
The assessment of safety in traditional toxicology protocols rely on evidence arising from observed adverse events (AEs) in animals and on establishing their correlation with different measures of drug exposure (e.g., Cmax and AUC). Such correlations, however, ignore the role of biomarkers, which can provide further insight into the underlying ...
Sivieri Katia K 1 Department of Food & Nutrition, Faculty of Pharmaceutical Sciences, São Paulo State University , Araraquara, São Paulo, Brazil - - 2014
Abstract Maintaining "gut health" is a goal for scientists throughout the world. Therefore, microbiota management models for testing probiotics, prebiotics, and synbiotics have been developed. The SHIME(®) model was used to study the effect of fructooligosaccharide (FOS) on the fermentation pattern of the colon microbiota. Initially, an inoculum prepared from ...
Pelletier Tara A TA Department of Evolution, Ecology, and Organismal Biology, The Ohio State University, 318 W. 12th Avenue, Columbus, OH, - - 2014
Model-based analyses are common in phylogeographic inference because they parameterize processes such as population division, gene flow and expansion that are of interest to biologists. Approximate Bayesian Computation is a model-based approach that can be customized to any empirical system and used to calculate the relative posterior probability of several ...
Abdalmula A A Faculty of Veterinary Science, University of Melbourne, Parkville, Victoria, - - 2014
Collagen induced arthritis (CIA) is the most studied and used rheumatoid arthritis (RA) model in animals, as it shares many pathological and immunological features of the human disease. The aim of this study was to characterize clinical and immunological aspects of the ovine CIA model, and develop lameness and histopathological ...
Xia Fei F School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive 637551, - - 2014
Elastic network models (ENM) are based on the idea that the geometry of a protein structure provides enough information for computing its fluctuations around its equilibrium conformation. This geometry is represented as an elastic network (EN) that is, a network of links between residues. A spring is associated with each ...
Liu Fei F The Key Lab of Drug Metabolism and Pharmacokinetics, Beijing Institute of Pharmacology and Toxicology, No. 27 Taiping Road, Beijing, 100850, PR China; Department of Pharmacy, the First Affiliated Hospital of PLA, No.51 Fucheng Road, Beijing, 10048, PR - - 2014
YQA-14 is a novel and selective dopamine D3 receptor antagonist, with potential for treatment of drug addiction. However, the earlier compounds in its structural class tend to have poor oral bioavailability. The objectives of this study were to characterize the preclinical absorption, distribution, metabolism, and excretion (ADME) properties and pharmacokinetics ...
van Ravenzwaay B B BASF SE, Ludwigshafen, Germany. Electronic address: - - 2014
The identification of the no observed adverse effect level (NOAEL) is the key regulatory outcome of toxicity studies. With the introduction of "omics" technologies into toxicological research, the question arises as to how sensitive these technologies are relative to classical regulatory toxicity parameters. BASF SE and metanomics developed the in ...
Johnston Marie M Institute of Applied Health Sciences, University of Aberdeen, - - 2014
In studies involving theoretical constructs, it is important that measures have good content validity and that there is not contamination of measures by content from other constructs. While reliability and construct validity are routinely reported, to date, there has not been a satisfactory, transparent, and systematic method of assessing and ...
Alipouri Yousef Y Faculty of Electrical Engineering, Iran University of Science and Technology, Tehran, - - 2014
The Minimum Variance Lower Bound (MVLB) represents the best achievable controller capability in a variance sense. Estimation and realization of MVLB for nonlinear systems confront some difficulties. Hence, almost all methods introduced so far estimate MVLB for a certain structure (e.g., NARMAX) or controller (e.g. PID). In this paper, MVLB ...
Kauppinen Ari A School of Pharmacy, Promis Centre, Faculty of Health Sciences, University of Eastern Finland, P.O. Box 1627, Kuopio FI-70211, Finland. Electronic address: - - 2014
This study assessed the validity of a multipoint near-infrared (NIR) spectroscopy method for in-line moisture content analysis during a freeze-drying process. It is known that the moisture content affects the stability of a freeze-dried product and hence it is a major critical quality attribute. Therefore assessment of the validity of ...
Teplyakov Alexey A Janssen Research & Development, LLC, 1400, McKean Road, Spring House, PA, 19477, - - 2014
To assess the state of the art in antibody structure modeling, a blinded study was conducted. Eleven unpublished Fab crystal structures were used as a benchmark to compare Fv models generated by 7 structure prediction methodologies. In the first round, each participant submitted 3 non-ranked complete Fv models for each ...
Carvalho-Lobato Patricia P 1 Human Anatomy and Embryology Unit, HUBc, University of Barcelona , Barcelona, - - 2014
Abstract Objective: This review attempts to organize the existing published literature regarding tooth movement in orthodontic treatment when low-level laser therapy (LLLT) is applied. Background data: The literature discusses different methods that have been developed to motivate the remodeling and decrease the duration of orthodontic treatment. The application of LLLT ...
Couture Raoul-Marie RM Norwegian Institute for Water Research, Gaustadalléen 21, 0349 Oslo, Norway. - - 2014
A model network comprising climate models, a hydrological model, a catchment-scale model for phosphorus biogeochemistry, and a lake thermodynamics and plankton dynamics model was used to simulate phosphorus loadings, total phosphorus and chlorophyll concentrations in Lake Vansjø, Southern Norway. The model network was automatically calibrated against time series of hydrological, ...
Rickard Rory F RF Academic Department of Military Surgery and Trauma, Royal Centre for Defence Medicine, Birmingham, United Kingdom; Department of Plastic Surgery, Derriford Hospital, Plymouth, United Kingdom; Division of Plastic, Reconstructive and Maxillofacial Surgery, Department of Surgery, University of Cape Town, Cape Town, South Africa. Electronic address: - - 2014
The use of fascial perforating vessels as recipients for microvascular composite tissue autotransplants has led to vessel diameter discrepancy becoming an increasingly common finding. Little evidence, however, is available to direct the choice of anastomotic technique where a discrepancy exists. We have been studying two methods of anastomosing arteries where ...
Bruyndonckx Robin R Interuniversity Institute for Biostatistics and Statistical Bioinformatics (I-BIOSTAT), University of Hasselt, Diepenbeek, - - 2014
To complement analyses of the linear trend and seasonal fluctuation of European outpatient antibiotic use expressed in defined daily doses (DDD) by analyses of data in packages, to assess the agreement between both measures and to study changes in the number of DDD per package over time. Data on outpatient ...
Boettcher H S HS Dyrlægerne Univet, Jernbanegade 10, 6650 Brørup, - - 2014
It is proposed that a softening of the suspensory tissue in the claw is involved in the development of lameness and claw lesions in cattle. A relatively small amount of research has been carried out to verify this theory. Research in this area would be simplified if mechanical testing of ...
Kogel Ulrike U Philip Morris International R&D, Philip Morris Research Laboratories GmbH, Fuggerstrasse 3, 51149 Cologne, Germany; Philip Morris International R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, 2000 Neuchâtel, Switzerland. Electronic address: - - 2014
Towards a systems toxicology-based risk assessment, we investigated molecular perturbations accompanying histopathological changes in a 28-day rat inhalation study combining transcriptomics with classical histopathology. We demonstrated reduced biological activity of a prototypic modified risk tobacco product (pMRTP) compared with the reference research cigarette 3R4F. Rats were exposed to filtered air ...
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