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Yu Eunjong E 0000-0002-4098-5153 Department of Architectural Engineering, Hanyang University 222, Wangsimni-ro, Seongdong-gu, Seoul 133-791, Republic of - - 2014
Damage of a 5-story framed structure was identified from two types of measured data, which are frequency response functions (FRF) and natural frequencies, using a finite element (FE) model updating procedure. In this study, a procedure to determine the appropriate weightings for different groups of observations was proposed. In addition, ...
Monzo Carlos C 0000-0003-3883-3588 Computer Science, Multimedia and Telecommunication Studies, Universitat Oberta de Catalunya (UOC), Rambla del Poblenou 156, 08018 Barcelona, - - 2014
This paper presents the perceptual experiments that were carried out in order to validate the methodology of transforming expressive speech styles using voice quality (VoQ) parameters modelling, along with the well-known prosody (F 0, duration, and energy), from a neutral style into a number of expressive ones. The main goal ...
Rudolph-Lilith Michelle M Unité de Neurosciences, Information et Complexité, CNRS, 1 Avenue de la Terrasse, 91198 Gif-sur-Yvette, - - 2014
We introduce an analytic model for directed Watts-Strogatz small-world graphs and deduce an algebraic expression of its defining adjacency matrix. The latter is then used to calculate the small-world digraph's asymmetry index and clustering coefficient in an analytically exact fashion, valid nonasymptotically for all graph sizes. The proposed approach is ...
Monfardini Elisabetta E INSERM, U1028, Lyon Neuroscience Research Center, ImpAct Team, Lyon, France ; CNRS, UMR5292, Lyon Neuroscience Research Center, ImpAct Team, Lyon, France ; University Lyon, Lyon, France ; Institut de Médecine Environnementale, Paris, - - 2014
Monkeys readily learn to discriminate between rewarded and unrewarded items or actions by observing their conspecifics. However, they do not systematically learn from humans. Understanding what makes human-to-monkey transmission of knowledge work or fail could help identify mediators and moderators of social learning that operate regardless of language or culture, ...
Song Minryung R MR Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, South - - 2014
Because most rewarding events are probabilistic and changing, the extinction of probabilistic rewards is important for survival. It has been proposed that the extinction of probabilistic rewards depends on arousal and the amount of learning of reward values. Midbrain dopamine neurons were suggested to play a role in both arousal ...
Kalinowska Barbara B Department of Bioinformatics and Telemedicine, Medical College, Jagiellonian University, Krakow, Poland; Faculty of Physics, Astronomy and Applied Computer Science - Jagiellonian University, Krakow, - - 2014
This work discusses the role of unstructured polypeptide chain fragments in shaping the protein's hydrophobic core. Based on the "fuzzy oil drop" model, which assumes an idealized distribution of hydrophobicity density described by the 3D Gaussian, we can determine which fragments make up the core and pinpoint residues whose location ...
Schermelleh-Engel Karin K Department of Psychology, Goethe University Frankfurt, - - 2014
Evaluating model fit in nonlinear multilevel structural equation models (MSEM) presents a challenge as no adequate test statistic is available. Nevertheless, using a product indicator approach a likelihood ratio test for linear models is provided which may also be useful for nonlinear MSEM. The main problem with nonlinear models is ...
Liu Yang Y 0000-0002-1187-6388 School of Transportation Science and Engineering, Harbin Institute of Technology, Harbin 150090, China ; Postdoctoral Station of Civil Engineering, Harbin Institute of Technology, Harbin 150090, - - 2014
Updating the structural model of complex structures is time-consuming due to the large size of the finite element model (FEM). Using conventional methods for these cases is computationally expensive or even impossible. A two-level method, which combined the Kriging predictor and the component mode synthesis (CMS) technique, was proposed to ...
Thomsen Kim K Department of Clinical Microbiology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, - - 2014
Medical biofilms have attracted substantial attention especially in the past decade. Animal models are contributing significantly to understand the pathogenesis of medical biofilms. In addition, animal models are an essential tool in testing the hypothesis generated from clinical observations in patients and preclinical testing of agents showing in vitro antibiofilm ...
Ericsson Aaron C AC Mutant Mouse Regional Resource Center (MMRRC), Rat Resource and Research Center (RRRC), Department of Veterinary Pathobiology, University of Missouri, Columbia, Missouri, USA. - - 2014
Segmented filamentous bacteria (SFB) are commensal bacteria that were first identified in the ilea of mice and rats. Morphologically similar bacteria occur in a broad range of host species, but all strains have been refractory to in vitro culture thus far. Although SFB were once considered innocuous members of the ...
Aguilar Alex A Department of Animal Biology and Biodiversity Research Institute (IrBio), Faculty of Biology, University of Barcelona, Barcelona, - - 2014
The finding that tissue δ15N values increase with protein catabolism has led researchers to apply this value to gauge nutritive condition in vertebrates. However, its application to marine mammals has in most occasions failed. We investigated the relationship between δ15N values and the fattening/fasting cycle in a model species, the ...
Polade Suraj D SD Climate, Atmospheric Science and Physical Oceanography (CASPO), Scripps Institution of Oceanography, La Jolla, CA, - - 2014
Future changes in the number of dry days per year can either reinforce or counteract projected increases in daily precipitation intensity as the climate warms. We analyze climate model projected changes in the number of dry days using 28 coupled global climate models from the Coupled Model Intercomparison Project, version ...
van Hasselt J G Coen JG Department of Clinical Pharmacology, Netherlands Cancer Institute, Plesmanlaan 121, P.O. Box 1066 CX, Amsterdam, The Netherlands ; Department of Pharmacy & Pharmacology, Netherlands Cancer Institute/Slotervaart Hospital, Louwesweg 6, P.O. Box 90440, 1006 BK Amsterdam, The - - 2014
This work describes a first population pharmacokinetic (PK) model for free and total cefazolin during pregnancy, which can be used for dose regimen optimization. Secondly, analysis of PK studies in pregnant patients is challenging due to study design limitations. We therefore developed a semiphysiological modeling approach, which leveraged gestation-induced changes ...
Boughammoura Sondès S Faculty of Sciences of Monastir, UR Electrolytes, University of Monastir, 5000 Monastir, - - 2014
We have proved in details that the dielectric friction remains the principal frictional effect for a stretched polyion modeled as a chain of charged spheres, whereas, in the case of Manning's model (infinite thread with a continuous distribution of charge), this friction effect is nonexistent. According to this chain model, ...
Song Yunke Y Biomedical Engineering Department, Johns Hopkins University, Baltimore, Maryland, United States of - - 2014
Adapter ligation is a critical first step in many microRNA analysis methods including microarray, qPCR, and sequencing. Previous studies have shown that ligation bias can have dramatic effects on both the fidelity of expression profiles and reproducibility across samples. We have developed a method for high efficiency and low bias ...
Jordán Cristina C Instituto de Matemáticas Multidisciplinar, Universitat Politècnica de València, Camino de Vera s/n, 46022 Valencia, - - 2014
An n × n matrix is called an N 0-matrix if all its specified principal minors are nonpositive. In the context of partial matrices, a partial matrix is called a partial N 0-matrix if all its specified principal minors are nonpositive. In this paper we characterize the existence of an ...
Badhan Raj K Singh RK Manchester Pharmacy School, the University of Manchester, Oxford Road, Manchester, M13 9PT, UK. - - 2014
Central nervous system (CNS) drug disposition is dictated by a drug's physicochemical properties and its ability to permeate physiological barriers. The blood-brain barrier (BBB), blood-cerebrospinal fluid barrier and centrally located drug transporter proteins influence drug disposition within the central nervous system. Attainment of adequate brain-to-plasma and cerebrospinal fluid-to-plasma partitioning is ...
Jones Daniel O B DO National Oceanography Centre, University of Southampton Waterfront Campus, European Way, Southampton, SO14 3ZH, - - 2013
Seafloor organisms are vital for healthy marine ecosystems, contributing to elemental cycling, benthic remineralization, and ultimately sequestration of carbon. Deep-sea life is primarily reliant on the export flux of particulate organic carbon from the surface ocean for food, but most ocean biogeochemistry models predict global decreases in export flux resulting ...
Shams Shiva S IASMA Research and Innovation Centre, Istituto Agrario di S. Michele all'Adige, Fondazione E. Mach, Via E. Mach 1, 38010 S. Michele all'Adige (Trento), Italy; Human and Environmental Toxicology Group, Department of Biology, University of Konstanz, P.O. Box X-918, D-78457 Konstanz, Germany. Electronic address: - - 2013
In this study, we investigated the kinetic aspects of the microcystin (MC) transfer from Planktothrix rubescens to Daphnia magna by carrying out exposure experiments in small simple mesocosms. We hypothesized that higher fractions of toxic cyanobacteria in the diet of grazers would shift the balance towards a greater than linear, ...
Posada-Izquierdo Guiomar D GD Department of Food Science and Technology, University of Cordoba, Campus de Rabanales, Edificio Darwin-C1, 14014 Córdoba, Spain. Electronic address: - - 2013
The purpose of this study was to evaluate and model the growth of Escherichia coli O157:H7 in fresh-cut lettuce submitted to a neutral electrolyzed water (NEW) treatment, packaged in passive modified atmosphere and subsequently stored at different temperatures (4, 8, 13, 16°C) for a maximum of 27days. Results indicated that ...
Aher Rahul Balasaheb - - 2013
Both a development of resistance to artemisinin monotherapy and lack of effective vaccine against malaria have created the urgent need for the development of new and efficient antimalarial agents. In this background, we have developed here a linear discriminant analysis (LDA) model and a few 3D-pharmacophore models for the classification ...
Sonne Christian C Department of Bioscience, Arctic Research Centre, Aarhus University, Denmark. Electronic address: - - 2013
Human exposure to persistent organic pollutants (POPs) and the potential health impact in the Arctic far from the emission sources have been highlighted in numerous studies. As a supplement to human POP biomonitoring studies, a physiologically based pharmacokinetic (PBPK) model was set up to estimate the fate of POPs in ...
Loerakker Sandra S Department of Biomedical Engineering, Eindhoven University of Technology, P.O. Box 513, 5600 MB , Eindhoven, The Netherlands, - - 2013
Collagen is the main load-bearing component of many soft tissues and has a large influence on the mechanical behavior of tissues when exposed to mechanical loading. Therefore, it is important to increase our understanding of collagen remodeling in soft tissues to understand the mechanisms behind pathologies and to control the ...
Lee Jui-Huan JH Institute of Occupational Medicine and Industrial Hygiene, College of Public Health, National Taiwan University, Taipei, - - 2013
This study is conducted to characterize the intra-urban distribution of NOx and NO2; develop land use regression (LUR) models to assess outdoor NOx and NO2 concentrations, using the ESCAPE modeling approach with locally specific land use data; and compare NOx and NO2 exposures for children in the Taipei Metropolis by ...
Shah Dhaval K DK Department of Pharmaceutical Sciences, University at Buffalo, The State University of New York, 452 Kapoor Hall, Buffalo, NY, 14260, - - 2013
We are investigating an inverse targeting strategy to reduce the dose limiting systemic toxicities resultant from intraperitoneal administration of topotecan, a model chemotherapeutic drug. This approach utilizes systemic co-administration of anti-topotecan antibodies to alter the plasma and tissue disposition kinetics of topotecan. To better predict the effects of 8C2, a ...
Zhao Guoliang G Faculty of Electronic Information and Electronic Engineering, Dalian University of Technology, Dalian 116024, China ; Modern Manufacture Engineering Center, Heilongjiang University of Science and Technology, Harbin 150022, - - 2013
This paper proposes new methodologies for the design of adaptive integral-sliding mode control. A tensor product model transformation based adaptive integral-sliding mode control law with respect to uncertainties and perturbations is studied, while upper bounds on the perturbations and uncertainties are assumed to be unknown. The advantage of proposed controllers ...
Wijesekara Gayan Nishad GN Department of Geomatics Engineering, University of Calgary, Calgary, AB, Canada, - - 2013
The Elbow River watershed in Alberta covers an area of 1,238 km(2) and represents an important source of water for irrigation and municipal use. In addition to being located within the driest area of southern Canada, it is also subjected to considerable pressure for land development due to the rapid ...
Zhang Yejia Y Departments of ‡Orthopedic Surgery, †Biochemistry *Physical Medicine & Rehabilitation, Rush University Medical Center, Chicago, IL; [Black up-pointing triangle]Department of Orthopedic Surgery, Second Hospital of Xiangya, Central South University, Hunan, P. R. China; ΔQujing No. 1 Hospital, Orthopedic Department, Yunnan Province, PR China; #Department of Physical Medicine and Rehabilitation, Perelman School of Medicine, University of Pennsylvania, and Philadelphia VA Medical Center, Philadelphia, - - 2013
Study Design. Histological features of the intervertebral disc/endplate interface were analyzed.Objective. To define cartilaginous and bony vertebral endplate in commonly used laboratory animals and compare with that of the humans.Summary of Background Data. Endplates are crucial for the IVD nutrient supply: the IVDs have limited blood supply; most nutrients diffuse ...
Ishak Mustapha M Department of Physics, The University of Texas at Dallas, Richardson, Texas 75083, - - 2013
Probes of cosmic expansion constitute the main basis for arguments to support or refute a possible apparent acceleration due to different expansion rates in the Universe as described by inhomogeneous cosmological models. We present in this Letter a separate argument based on results from an analysis of the growth rate ...
Sun Xian-Qiang XQ 1] Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China [2] Division of Theoretical Chemistry and Biology, School of Biotechnology, KTH Royal Institute of Technology, S-106 91 Stockholm, - - 2013
Aim:To develop a novel 3D-QSAR approach for study of the epidermal growth factor receptor tyrosine kinase (EGFR TK) and its inhibitors.Methods:One hundred thirty nine EGFR TK inhibitors were classified into 3 clusters. Ensemble docking of these inhibitors with 19 EGFR TK crystal structures was performed. Three protein structures that showed ...
Thomas Trayder - - 2013
We have developed homology models of the acetylcholine muscarinic receptors M1R-M5R, based on the β2-adrenergic receptor crystal as the template. This is the first report of homology modeling of all five subtypes of acetylcholine muscarinic receptors with binding sites optimized for ligand binding. The models were evaluated for their ability ...
Chen Tianju T Key Laboratory of Biofuels, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, 189 Songling Road, Qingdao 266101, PR - - 2013
The gasification kinetic analysis of the three pseudocomponents (hemicellulose, cellulose and lignin) of biomass decomposition in the agent of CO2 were investigated. The Multi-peaks method was used to fit the Gaussian distribution model of DTG curves. The Friedman method was used to estimate the effective Eα, and the master plot ...
Faraj Chafika - - 2013
In Morocco, the main strategies of leishmaniasis vector control are based on environmental modifications. Use of local residual indoor spraying with synthetic pyrethroids is often envisaged. The need to evaluate this control method is essential. The current study was conducted to determine the efficacy of an alphacypermethrin IRS program against ...
Dastoor Ashu P - - 2013
High levels of mercury in marine mammals threaten the health of Arctic inhabitants. Whether the Arctic Ocean (AO) is a sink or a source of atmospheric mercury is unknown. Given the paucity of observations in the Arctic, models are useful in addressing this question. GEOS-Chem and GRAHM, two complex numerical ...
Sweeney Lisa M LM Henry M. Jackson Foundation for the Advancement of Military Medicine, Naval Medical Research Unit Dayton, Wright-Patterson AFB, OH - - 2013
The ten Berge model, also known as the toxic load model, is an empirical approach in hazard assessment modeling for estimating the relationship between the inhalation toxicity of a chemical and the exposure duration. The toxic load (TL) is normally expressed as a function of vapor concentration (C) and duration ...
Tang Min M Ewha Womans University, - - 2013
We present fast CCD algorithm for general rigid and articulated models based on conservative advancement. We have implemented the CCD algorithm with two different acceleration techniques which can handle rigid models, and have extended one of them to articulated models. The resulting algorithms take a few milliseconds for rigid models ...
Taffetani M M Department of Chemistry, Materials and Chemical Engineering, Laboratory of Biological Structure Mechanics (LaBS), Politecnico di Milano, Milano, Italy. Electronic address: - - 2013
Articular cartilage is a soft hydrated tissue that facilitates proper load transfer in diarthroidal joints. The mechanical properties of articular cartilage derive from its structural and hierarchical organization that, at the micrometric length scale, encompasses three main components: a network of insoluble collagen fibrils, negatively charged macromolecules and a porous ...
Poniatowski Lauren H - - 2013
Background: The objective was to determine the acceptability and preliminary construct validity for a high-fidelity synthetic renal pelvis/ureter tissue analogue model for use as a simulation model for training laparoscopic pyeloplasty. Methods: The pyeloplasty model was designed with incorporated assessment lines for use in post-task Black Light Assessment of Surgical ...
Waran Vicknes - - 2013
The advent of multimaterial 3D printers allows the creation of neurosurgical models of a more realistic nature, mimicking real tissues. The authors used the latest generation of 3D printer to create a model, with an inbuilt pathological entity, of varying consistency and density. Using this model the authors were able ...
Grenier Stephanie S Laboratory for Soft Tissue Research, Tissue Engineering, Regeneration and Repair Program, The Hospital for Special Surgery, New York, NY 10021, United States. Electronic address: - - 2013
The objective of this study was to develop an in vitro cartilage degradation model that emulates the damage seen in early-stage osteoarthritis. To this end, cartilage explants were collagenase-treated to induce enzymatic degradation of collagen fibers and proteoglycans at the articular surface. To assess changes in mechanical properties, intact and ...
Tobin Chase A - - 2013
The commonly used methods to quantify axon numbers and mean area include manual and semiautomated procedures. The authors introduce a new fully automated method of morphometric analysis using ImageJ and Paint.net software to improve efficiency and accuracy. A total of six rat sciatic nerves were examined for their axon numbers ...
Pancheri F Q FQ Department of Mechanical Engineering, Tufts University, Medford, MA, United - - 2013
In this paper we propose a constitutive model to analyze in-plane extension of goat fascia lata. We first perform a histological analysis of the fascia that shows a well-organized bi-layered arrangement of undulated collagen fascicles oriented along two well defined directions. To develop a model consistent with the tissue structure ...
Su Shiliang - - 2013
A comparison of different transportation route types and their combined effects on landscape diversity was conducted within Tiaoxi watershed (China) between 1994 and 2005. Buffer analysis and Mann-Kendall's test were used to quantify the relationships between distance from transportation routes (railway, highway, national, and provincial road) and a family of ...
Oakes Jessica M - - 2013
Image-based in silico modeling tools provide detailed velocity and particle deposition data. However, care must be taken when prescribing boundary conditions to model lung physiology in health or disease, such as in emphysema. In this study, the respiratory resistance and compliance were obtained by solving an inverse problem; a 0D ...
Watters Orla - - 2013
The technical advances made in microscopy have been matched by an increase in the application of fluorescent microscopy to answer scientific questions. While analysis of fluorescent microscopy images represents a powerful tool, one must be aware of the potential pitfalls. Frequently, the analysis methods applied involve at least some manual ...
Pardal David - - 2013
Abstract Resveratrol, a polyphenolic phytoalexin found in many plants, has been reported to have antiobesogenic effects in several animal and in vitro models. Zebrafish present several technical advantages that place them at an interesting, halfway point between in vitro and rodent models. The aim of the present work was to ...
Capogrosso Marco - - 2013
Epidural electrical stimulation (EES) of lumbosacral segments can restore a range of movements after spinal cord injury. However, the mechanisms and neural structures through which EES facilitates movement execution remain unclear. Here, we designed a computational model and performed in vivo experiments to investigate the type of fibers, neurons, and ...
Tong Peijian - - 2013
Ethnopharmacological relevance: Fuzi is an effective but toxic traditional Chinese medicine (TCM) derived from Aconitum carmichaeli. In our previous study, detoxicated Fuzi (d-Fuzi) has been originally developed with no toxicity but significant efficacy. However, whether d-Fuzi can be used for therapy of osteoarthritis (OA), remain unknown.Materials and methods: Severe OA ...
Li Keqiang - - 2013
With the recent development of society and economy in the cities of Huludao and Jinzhou, Liaoning Province, China, environment and ecosystem problems have become increasingly serious in Jinzhou Bay, China, because of the increasing amount of heavy metal pollutants being discharged. To solve these problems, a water quality model of ...
Bozkurt Hayriye H Department of Food Science and Technology, The University of Tennessee, 2600 River Drive, Knoxville, TN 37996-4591, - - 2014
Control of seafood-associated norovirus outbreaks has become an important priority for public health authorities. Due to the absence of human norovirus infectivity assays, cultivable surrogates such as feline calicivirus (FCV-F9) and murine norovirus (MNV-1) have been used to begin to understand their thermal inactivation behavior. In this study, the effect ...
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