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Cui Hongyan H State Key Laboratory of Networking and Switching Technology, Beijing University of Posts and Telecommunications, 100876, China; Key Laboratory of Network System Architecture and Convergence, Beijing University of Posts and Telecommunications, 100876, China. Electronic address: - - 2014
The Echo State Network (ESN) has attracted wide attention for its superior performance in chaos time-series prediction. However, the complicated ESN topologies and the random reservoirs are difficult to implement in practice. We propose a hybrid circle reservoir (HCR) ESN architecture that comprises the following features: (1) built with low ...
Antoine Elizabeth E EE Virginia Tech, Mechanical Engineering , 813 Giles Rd , Blacksburg, Virginia, United States, 24060 , 7857870546 , Virginia Tech, Mechanical Engineering , Randolph 12D , Blacksburg , Virginia, United States, 24061 ; - - 2014
Type I collagen hydrogels have been used successfully as 3D substrates for cell culture and have shown promise as scaffolds for engineered tissues and tumors. A critical step in the development of collagen hydrogels as viable tissue mimics is quantitative characterization of hydrogel properties and their correlation with fabrication parameters, ...
Bender Brendan B Department of Clinical Pharmacology, Genentech Inc., South San Francisco, California, USA, - - 2014
Trastuzumab emtansine (T-DM1) is an antibody-drug conjugate (ADC) therapeutic for treatment of human epidermal growth factor receptor 2 (HER2)-positive cancers. The T-DM1 dose product contains a mixture of drug-to-antibody ratio (DAR) moieties whereby the small molecule DM1 is chemically conjugated to trastuzumab antibody. The pharmacokinetics (PK) underlying this system and ...
Scholz Stefan S UFZ - Helmholtz Centre for Environmental Research, Department of Bioanalytical Ecotoxicology, Permoserstr. 15, 04318 Leipzig, Germany. Electronic address: - - 2014
Distribution and marketing of chemicals require appropriate labelling of health, physical and environmental hazards according to the United Nations global harmonisation system (GHS). Labelling for (human) acute toxicity categories is based on experimental findings usually obtained by oral, dermal or inhalative exposure of rodents. There is a strong societal demand ...
Yu Hao H School of Environmental Science and Engineering, Liaoning Technical University, Fuxin 123000, China; State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin 150090, China. Electronic address: - - 2014
The elemental sulfur (S(0)) recovery was evaluated in the presence of nitrate in two development models of simultaneous desulfurization and denitrification (SDD) process. At the loading rates of 0.9kg S/(m(3)·day) for sulfide and 0.4kg N/(m(3)·day) for nitrate, S(0) conversion rate was 91.1% in denitrifying sulfide removal (DSR) model which was ...
Luo Tao T School of Environmental Science and Engineering, Zhejiang Gongshang University, Hangzhou 310012, - - 2014
A novel model-based adaptive control strategy for step-feed sequence batch reactors (SBRs) was developed and compared with traditional fixed-parameters control strategy and statically optimal parameters control strategy under influent fluctuation period. The SBR was operated with automatic alteration of the operating parameters based on the numerical calculation results of fully ...
Guth K K a Experimental Toxicology and Ecology , BASF SE , Ludwigshafen , - - 2014
Dermal absorption is a critical part in the risk assessment of complex mixtures such as agrochemical formulations. To reduce the number of in vivo or in vitro absorption experiments, the present study aimed to develop an in silico prediction model that considers mixture-related effects. Therefore, an experimental 'real-world' dataset derived ...
Yang F F College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, China; College of Veterinary Medicine, South China Agricultural University, Guangzhou, - - 2014
Residue depletion of marbofloxacin in broiler chicken after oral administration at 5 mg/kg/day for three consecutive days was studied in this study. The areas under the concentration-time curve from 0 h to ∞ (AUC0-∞ s) of marbofloxacin in tissues and plasma were used to calculate tissue/plasma partition coefficients (PX s). Based on ...
Huisman Floor F Department of Surgery, Academic Medical Center, Amsterdam, The Netherlands. Electronic address: - - 2014
Portal vein embolization (PVE) is a preoperative intervention to increase the future remnant liver (FRL) through regeneration of the non-embolized liver lobes. This review assesses all the relevant animal models of PVE available, to guide researchers who intend to study PVE. We performed a systematic literature search in Medline and ...
Davran-Candan Tugba - - 2014
In this study the interaction of CO2 with aqueous monoethanolamine (MEA), 2-amino-2-methyl-1-propanol (AMP), ethylenediamine (EDA), guanidine, and tetramethylguanidine (TMG) was studied by using density functional theory (DFT) modeling. MEA was chosen as the benchmark system and the reaction pathways of carbamate as well as bicarbonate formations were analyzed thoroughly in ...
Herman Joseph L JL † - Department of Statistics, University of Oxford; × - Division of Mathematical Biology, National Institute of Medical Research, London; ‡ - Department of Statistical Science, Duke University; □ - Department of Computer Science, Duke University.† - Department of Statistics, University of Oxford; × - Division of Mathematical Biology, National Institute of Medical Research, London; ‡ - Department of Statistical Science, Duke University; □ - Department of Computer Science, Duke University. - - 2014
For sequences that are highly divergent, there is often insufficient information to infer accurate alignments, and phylogenetic uncertainty may be high. One way to address this issue is to make use of protein structural information, since structures generally diverge more slowly than sequences. In this work, we extend a recently ...
Matuszewski Sebastian S Mathematics and BioSciences Group, Faculty of Mathematics, University of Vienna, Oskar-Morgenstern-Platz 1, A-1090, Vienna, Austria. - - 2014
Fisher's geometric model has been widely used to study the effects of pleiotropy and organismic complexity on phenotypic adaptation. Here, we study a version of Fisher's model in which a population adapts to a gradually moving optimum. Key parameters are the rate of environmental change, the dimensionality of phenotype space, ...
Hasegawa Takanori T Bioinformatics Center, Institute for Chemical Research, Kyoto University, Gokasho, Uji, Kyoto, Japan. Electronic address: - - 2014
Recently, several biological simulation models of, e.g., gene regulatory networks and metabolic pathways, have been constructed based on existing knowledge of biomolecular reactions, e.g., DNA-protein and protein-protein interactions. However, since these do not always contain all necessary molecules and reactions, their simulation results can be inconsistent with observational data. Therefore, ...
Jones Bleddyn - - 2014
Abstract Purpose: To review the available experimental animal and patient data on response of the spinal cord to re-irradiation in order to identify appropriate data sets to investigate the clinical potential of models that would allow evaluation of the increase in the re-treatment dose with elapsed time from the initial ...
Parisi A V AV Faculty of Health, Engineering and Sciences, University of Southern Queensland, Toowoomba, Australia. Electronic address: - - 2014
The influence of cloud on the solar UVA (320-400nm) exposures over five minute periods on a horizontal plane has been investigated. The first approach used cloud modification factors that were evaluated using the influence of clouds on the global solar exposures (310-2800nm) and a model developed to apply these to ...
Horný Lukáš L Czech Technical University in Prague, Faculty of Mechanical Engineering, Technická 4, 166 07 Prague, Czech Republic. Electronic address: - - 2014
The abdominal aorta is susceptible to age-related pathological changes (arteriosclerosis, atherosclerosis, aneurysm, and tortuosity). Computational biomechanics and mechanobiology provide models capable of predicting mutual interactions between a changing mechanical environment and patho-physiological processes in ageing. However, a key factor is a constitutive equation which should reflect the internal tissue architecture. ...
Yang Jianxin J Department of Applied Mathematics, Nanjing University of Science and Technology, Nanjing 210094, China. - - 2014
In this paper, an age-structured epidemic model is formulated to describe the transmission dynamics of cholera. The PDE model incorporates direct and indirect transmission pathways, infection-age-dependent infectivity and variable periods of infectiousness. Under some suitable assumptions, the PDE model can be reduced to the multi-stage models investigated in the literature. ...
Moroni Maria M *Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD, USA; †Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, MHH, Hannover, Germany; ‡Bundeswehr Institute of Radiobiology affiliated to the University Ulm, Munich, - - 2014
The minipig is emerging as a potential alternative non-rodent animal model. Several biological markers (e.g., blood counts, laboratory parameters, and clinical signs) have been proposed for rapid triage of radiation victims. Here, the authors focus on the significance of bio-indicators for prediction of survivors after irradiation and compare it with ...
Abell C E CE 1 Department of Animal Science, Iowa State University, Ames, Iowa 50011, - - 2014
Feet and legs issues are some of the main causes for sow removal in the US swine industry. More timely lameness detection among breeding herd females will allow better treatment decisions and outcomes. Producers will be able to treat lame females before the problem becomes too severe and cull females ...
Chandola Himanshu H Department of Computer Science, Dartmouth College, Hanover, NH 03755, - - 2014
In studying interacting proteins, complementary insights are provided by analyzing both the association model (the stoichiometry and affinity constants of the intermediate and final complexes) and the quaternary structure of the resulting complexes. Many current methods for analyzing protein interactions either give a binary answer to the question of association ...
Weichenberger Christian X CX Center for Biomedicine, European Academy of Bozen/Bolzano (EURAC), Viale Druso 1, I-39100 Bozen/Bolzano, - - 2014
The probabilistic estimate of the solvent content (Matthews probability) was first introduced in 2003. Given that the Matthews probability is based on prior information, revisiting the empirical foundation of this widely used solvent-content estimate is appropriate. The parameter set for the original Matthews probability distribution function employed in MATTPROB has ...
Vigil Jacob M JM Department of Psychology,University of New Mexico,Albuquerque, NM - - 2014
Self-reported opinions and judgments may be more rooted in expressive biases than in cognitive processing biases, and ultimately operate within a broader behavioral style for advertising the capacity - versus the trustworthiness - dimension of human reciprocity potential. Our analyses of facial expression judgments of likely voters are consistent with ...
Jones Siân Bodfel SB Periodontology, Clinical Trials Unit, Bristol Dental School, Lower Maudlin St, Bristol, BS1 2LY, UK. Electronic address: - - 2014
To introduce a new interproximal mineralisation model and to investigate the effectiveness of novel toothpaste and dual phase gel formulations to remineralise acid softened enamel in a simulated interproximal environment. Specimens were positioned opposite each other with an approximately 100μm space between enamel surfaces to simulate an interproximal environment. Target ...
Frost Poul P Danish Ramazzini Centre, Department of Occupational Medicine, Aarhus University Hospital, Aarhus, - - 2014
We constructed a lower body job exposure matrix (JEM) based on five experts' assessments of occupational mechanical exposures. The aim of this study was to evaluate the face validity of the rankings of the job groups and the inter-rater agreement between the experts' rankings. The JEM cross tabulates the mean ...
Czaplicka Agnieszka A Faculty of Physics, Center of Excellence for Complex Systems Research, Warsaw University of Technology, Koszykowa 75, PL-00-662 Warsaw, - - 2014
We consider models of growing multilevel systems wherein the growth process is driven by rules of tournament selection. A system can be conceived as an evolving tree with a new node being attached to a contestant node at the best hierarchy level (a level nearest to the tree root). The ...
Lee Sang Bub SB Department of Physics, Kyungpook National University, Daegu 702-701, - - 2014
The nonequilibrium absorbing phase transition of the discrete conserved Manna model was studied via Monte Carlo simulations on a one-dimensional chain, using the natural initial states with a sequential update. The critical density of the particles was found to be smaller than the recently reported value, and the order-parameter exponent ...
Portela Rita de Cássia Quitete Rde - - 2014
The main threats to natural populations in terrestrial ecosystems have been widly recognized to be the habitat fragmentation and the exploitation of forest products. In this study, we compared the density of the populations and the structure of three tropical palm species, Astrocaryum aculeatissimum, Euterpe edulis and Geonoma schottiana. For ...
Zhang Xuezhi X Department of Applied Sciences and Mathematics, Arizona State University, Polytechnic Campus, Mesa, AZ, - - 2014
In this study, Chlorella zofingiensis harvesting by dissolved air flotation (DAF) was critically evaluated with regard to algal concentration, culture conditions, type and dosage of coagulants, and recycle ratio. Harvesting efficiency increased with coagulant dosage and leveled off at 81%, 86%, 91% and 87% when chitosan, Al(3+) , Fe(3+) , ...
Muir Dylan R DR Institute of Neuroinformatics, University of Zürich and ETH Zürich, Winterthurerstrasse 190, 8057 Zürich, Switzerland - - 2014
Competition is a well-studied and powerful mechanism for information processing in neuronal networks, providing noise rejection, signal restoration, decision making and associative memory properties, with relatively simple requirements for network architecture. Models based on competitive interactions have been used to describe the shaping of functional properties in visual cortex, as ...
Elmeliegy Mohamed M Department of Pharmaceutical Sciences, School of Pharmacy & Pharmaceutical Sciences, University at Buffalo-State University of New York, 370 Kapoor Hall, Buffalo, NewYork, 14214, - - 2014
Monoclonal antibodies (mAbs) exhibit biexponential profiles in plasma that are commonly described with a standard two-compartment model with elimination from the central compartment. These models adequately describe mAb plasma PK. However, these models ignore elimination from the peripheral compartment. This may lead to underestimation of the volume of distribution of ...
Paixão Paulo P iMed.UL, Faculdade de Farmácia, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003, Lisboa, Portugal, - - 2014
To develop a QSAR model, based on calculated molecular descriptors and an Artificial Neural Networks Ensemble (ANNE), for the estimation of rat tissue-to-blood partition coefficients (Kt:b), as well as the assessment of the applicability domain of the model and its utility in predicting the drug distribution in humans. A total ...
Mete Samiye S Faculty of Nursing, Dokuz Eylül University, İzmir, - - 2014
The aim of this study was to reveal experiences of nursing students and their advisors using theories and models in their PhD dissertations. The study adopted a descriptive qualitative approach. This study was performed with 10 PhD candidates and their five advisors from nursing faculty. The results of the study ...
Keller Arturo A - - 2014
Water quality trading has been proposed as a cost-effective approach for reducing nutrient loads through credit generation from agricultural or point source reductions sold to buyers facing costly options. We present a systematic approach to determine attenuation coefficients and their uncertainty. Using a process-based model, we determine attenuation with safety ...
Li Mengjie M Institute of Computational Comparative Medicine, College of Veterinary Medicine, Kansas State University, Manhattan, KS, United States of - - 2014
Extra-label drug use of Penicillin G in food producing animals may cause the excess of residues in tissue which will have potential damage to human health. Of all the antibiotics, penicillin G may have the greatest potential for producing allergic responses to the consumer of food animal products. There are, ...
Smith Tracy T TT University of North Carolina, - - 2014
Log-survivor analyses of interresponse times suggest that the behavior of rats responding under single variable-interval schedules is organized into bouts (i.e., periods of engagement and disengagement). Attempts to generalize this analysis to the key pecking in pigeons, however, have failed to produce the characteristic broken-stick appearance typically obtained with rats. ...
Rountrey Adam N AN Centre for Marine Futures, Oceans Institute, University of Western Australia, Crawley, WA, - - 2014
Ecological modeling shows that even small, gradual changes in body size in a fish population can have large effects on natural mortality, biomass, and catch. However, efforts to model the impact of climate change on fish growth have been hampered by a lack of long-term (multidecadal) data needed to understand ...
Morse Bridget L BL Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, 352 Kapoor Hall, Buffalo, New York, 14214-8033, USA, - - 2014
Overdose of γ-hydroxybutyrate (GHB) can result in severe respiratory depression. Monocarboxylate transporter (MCT) inhibitors, including L-lactate, increase GHB clearance and represent a potential treatment for GHB intoxication. GHB can also affect L-lactate clearance, and L-lactate has been reported to affect respiration. In this research, we characterize these toxicokinetic/toxicodynamic interactions between ...
Yoon Miyoung M Center for Human Health Assessment, The Hamner Institutes for Health Sciences, Research Triangle Park, NC, USA. Electronic address: - - 2014
In vitro-derived information has been increasingly used to support and improve human health risk assessment for exposure to chemicals. Physiologically based pharmacokinetic (PBPK) modeling is a key component in the movement toward in vitro-based risk assessment, providing a tool to integrate diverse experimental data and mechanistic information to relate in ...
Lutz S R SR Critical Zone Hydrology Group, Department of Earth Sciences, Faculty of Earth and Life Sciences, Vrije Universiteit Amsterdam , De Boelelaan 1085, 1081 HV Amsterdam, The - - 2014
Compound-specific stable isotope analysis (CSIA) serves as a tool for source apportionment (SA) and for the quantification of the extent of degradation (QED) of organic pollutants. However, simultaneous occurrence of mixing of sources and degradation is generally believed to hamper both SA and QED. On the basis of the linear ...
Morales-Mora M A MA Subgerencia de Protección Ambiental, PEMEX-Petroquímica, Jacarandas 100, Colonia Rancho Alegre, Coatzacoalcos, Veracruz, 96558, México, - - 2014
Human and ecotoxicological impacts were analyzed in the lower basin of the Coatzacoalcos River (Veracruz, State in Mexico). High pollution levels of contaminants from the oil industry have been reported in natural streams and the Coatzacoalcos River and in their sediments. USEtox™ model was employed to evaluate environmental fate, exposure, ...
Zhang Zaiyong Z Department Chemie, Biomolecular NMR and Munich Center for Integrated Protein Science, Technische Universität München, Lichtenbergstrasse 4, 85747, Garching, - - 2014
We have developed a novel and robust approach for automatic and unsupervised simultaneous nuclear Overhauser effect (NOE) assignment and structure determination within the CS-Rosetta framework. Starting from unassigned peak lists and chemical shift assignments, autoNOE-Rosetta determines NOE cross-peak assignments and generates structural models. The approach tolerates incomplete and raw NOE ...
Crase Beth B The Centre of Excellence for Environmental Decisions, School of Botany, University of Melbourne, Parkville, Melbourne, Vic., 3010, - - 2014
Species distribution models (SDMs) are widely used to forecast changes in the spatial distributions of species and communities in response to climate change. However, spatial autocorrelation (SA) is rarely accounted for in these models, despite its ubiquity in broad-scale ecological data. While spatial autocorrelation in model residuals is known to ...
Daghrir R R Centre des Technologies de l'Eau (CTE), 696, Avenue Sainte-Croix, Montréal, Quebec H4L 3Y2, Canada. Electronic address: - - 2014
The objective of the present work is to evaluate the potential of a photosonolysis process for the degradation of butyl-paraben (BPB). After 120min of treatment time, high removal of BPB was achieved by the photosonolysis (US/UV) process (88.0±0.65%) compared to the photochemical (UV) and the conventional ultrasonication (US) processes. Several ...
Xiaowei Huang H School of Food and Biological Engineering, Jiangsu University, 301 Xuefu Rd., 212013 Zhenjiang, Jiangsu, - - 2014
Flowering tea has become a popular beverage consumed across the world. Anthocyanins content is considered as an important quality index of flowering tea. The feasibility of using near infrared (NIR) spectra at the wavelength range of 10,000-4000cm(-1) for rapid and nondestructive determination of total anthocyanins content in flowering tea was ...
Pace Caterina C Università degli Studi di Torino, Dipartimento di Scienze Agrarie, Forestali e Alimentari, Via Leonardo da Vinci 44, 10095 Grugliasco (TO), - - 2014
The evolution of the content and profile of anthocyanins was studied in the skin and pulp of Gamay winegrapes during twelve days of carbonic maceration. The ripening effect was also investigated using berries belonging to two density classes (A=1094-1100kg/m(3) and B=1107-1115kg/m(3)). The ripest berries showed a higher extraction yield, even ...
Zhang Yuan Y Department of Medicine, University of Melbourne, St. Vincent's Hospital, Fitzroy, Victoria, - - 2014
Chronic kidney disease (CKD), and its associated cardiovascular events, is one of the major causes of morbidity and recurrent hospitalization in Asian Pacific region. The subtotal nephrectomy (STNx) model has remained the state-of-the-art prototype which closely mimics human CKD and cardiac-renal syndrome. In this article, we comprehensively outline the procedure ...
Tøndel Kristin - - 2014
Striking a balance between the degree of model complexity and parameter identifiably, while still producing biologically feasible simulations using modelling is a major challenge in computational biology. While these two elements of model development are closely coupled, parameter fitting from measured data and analysis of model mechanisms have traditionally been ...
Taraballi F F Pain Therapy Service, Fondazione IRCCS Policlinico San Matteo, via Golgi, 19-27100 Pavia, - - 2014
A new approach for tethering of bioactive molecules via arginine is proposed and validated on collagen 2D matrices. The method involves the introduction of a methyl ketone on arginine side-chains, followed by reaction with model alkoxyamino derivatives.
Poet Torka S TS Summit Toxicology , Richland, WA , USA - - 2014
Abstract 1.  Chlorpyrifos (CPF) is an important pesticide used to control crop insects. Human Exposures to CPF will occur primarily through oral exposure to residues on foods. A physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) model has been developed that describes the relationship between oral, dermal and inhalation doses of CPF and key ...
Sewer Alain - - 2014
High-quality expression data are required to investigate the biological effects of microRNAs (miRNAs). The goal of this study was, first, to assess the quality of miRNA expression data based on microarray technologies and, second, to consolidate it by applying a novel normalization method. Indeed, because of significant differences in platform ...
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