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Results 451 - 500 of 2144
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Kim Kyung-Ah - - 2013
This study sought to determine a mortality prediction model that could be used for triage in the setting of acute hemorrhage from trauma. To achieve this aim, various machine learning techniques were applied using the rat model in acute hemorrhage. Thirty-six anesthetized rats were randomized into three groups according to ...
Wang Xinchuang - - 2013
Monitoring the dynamics of forest biomass at various spatial scales is important for better understanding the terrestrial carbon cycle as well as improving the effectiveness of forest policies and forest management activities. In this article, field data and Landsat image data acquired in 1999 and 2007 were utilized to quantify ...
Choi Min Ji - - 2013
As a development strategy for backups of Fimasartan (1), a comparative molecular similarity indices analysis (CoMSIA) of a set of sixty-five 5-(biphenyl-2-yl)-1H-tetrazole derivatives has been performed to find out the pharmacophore elements for angiotensin II receptor type 1 (AT1) blockade. The most potent compound containing pyrimidin-4(3H)-one ring, Fimasartan (1) was ...
Lahijani Pooya - - 2013
This study investigates the influence of alkali (Na, K), alkaline earth (Ca, Mg) and transition (Fe) metal nitrates on CO2 gasification reactivity of pistachio nut shell (PNS) char. The preliminary gasification experiments were performed in thermogravimetric analyzer (TGA) and the results showed considerable improvement in carbon conversion; Na-char>Ca-char>Fe-char>K-char>Mg-char>raw char. Based ...
Kagan Leonid - - 2013
To investigate the biodistribution of amphotericin B (AmB) in mice and rats following administration of liposomal AmB (AmBisome®) using a physiologically-based pharmacokinetic (PBPK) modeling framework and to utilize this approach for predicting AmBisome® pharmacokinetics in human tissues. AmB plasma and tissue concentration-time data, following single and multiple intravenous administration of ...
Zhang Yong - - 2013
Climatic change is expected to affect the spatiotemporal patterns of airborne allergenic pollen, which has been found to act synergistically with common air pollutants, such as ozone, to cause allergic airway disease (AAD). Observed airborne pollen data from six stations from 1994 to 2011 at Fargo (North Dakota), College Station ...
Sokolis Dimitrios P - - 2013
This paper reports on the implementation of microstructurally-motivated models for material characterization of the passive esophagus and its layers. The principal findings afforded herewith were that the comprehensive model with two- and four-fiber family terms for elastin and collagen fitted more accurately the inflation/extension data of healthy rabbit esophagus than ...
Berriman A D C - - 2013
A multi-group semi-stochastic model is formulated to describe Salmonella dynamics on a pig herd within the UK and assess whether farm structure has any effect on the dynamics. The models include both direct transmission and indirect (via free-living infectious units in the environment and airborne infection). The basic reproduction number ...
Smith David W - - 2013
We propose a new non-linear poroelastic model that is suited to the analysis of soft tissues. In this paper the model is tailored to the analysis of cartilage and the engineering design of cartilage constructs. The proposed continuum formulation of the governing equations enables the strain of the individual material ...
Jo Dong Hyun - - 2013
Effective and validated animal models are valuable to investigate the pathogenesis and potential therapeutics for human diseases. There is much concern for diabetic retinopathy (DR) in that it affects substantial number of working population all around the world, resulting in visual deterioration and social deprivation. In this review, we discuss ...
Wu Zijun - - 2013
Continuous radon ((222)Rn) monitoring was conducted at two stations (site A and site B) with different perpendicular distance from the shoreline in Xiangshan Bay, East China Sea. Based on a (222)Rn balance model (various sources and sinks of (222)Rn in coastal water), the average rate of SGD was estimated to ...
Bendig Paul - - 2013
Fish is a major source of human exposure to polybrominated diphenyl ethers (PBDEs). Since fish is mainly consumed after cooking, this measure may alter the pattern and amounts of PBDEs which are finally consumed. To investigate this issue, we developed a model cooking apparatus consisting of a small glass bowl ...
Tosun Alev - - 2013
Abstract Context: Liverworts (Marchantiophyta) are the second largest group of bryophytes exhibiting promising pharmacological and biological activities. They have been used as remedies for cuts, fractures, burns, bruises, open wounds, inflammation and pneumonia. Objective: In the present study, eight liverwort species [Corsinia coriandrina (Spreng.) Lindb. (Corsiniaceae), Mannia androgyna (L.) A. ...
Yang F - - 2013
A physiologically based pharmacokinetics model was developed to predict tulathromycin concentrations in edible swine tissues. Physiological parameters included volumes of and plasma flows through different tissues which were obtained from the literatures. The tissue/plasma partition coefficient was calculated according to the area method, and the model was validated through a ...
Shen Gulou - - 2013
A hybrid statistical mechanical model, which is fully consistent with the bulk perturbed-chain statistical associating fluid theory (PC-SAFT) in describing properties of fluids, was developed by coupling density functional theory with PC-SAFT for the description of the inhomogeneous behavior of real chain molecules in nanopores. In the developed model, the ...
van Schijndel Marten - - 2013
Computational models of memory are often expressed as hierarchic sequence models, but the hierarchies in these models are typically fairly shallow, reflecting the tendency for memories of superordinate sequence states to become increasingly conflated. This article describes a broad-coverage probabilistic sentence processing model that uses a variant of a left-corner ...
Liu Changhui - - 2013
Perfluorinated chemicals (PFCs) are a group of compounds with varying carbon chains and functional groups. However, available toxicity study is mainly limited to dominant species. While many other PFCs are detected in the environment and biota, it is important to extend toxicity study to different types of PFCs to better ...
Bushmakin A G - - 2013
To apportion the direct effect and the indirect effect (through erections) that sildenafil (vs placebo) has on individual satisfaction and couple satisfaction over time, longitudinal mediation modeling was applied to outcomes on the Sexual Experience Questionnaire. The model included data from weeks 4 and 10 (double-blind phase) and week 16 ...
Lèbre Sophie - - 2013
We recently introduced a new molecular evolution model called the IDIS model for Insertion Deletion Independent of Substitution ([13,14]). In the IDIS model, the three independent processes of substitution, insertion and deletion of residues have constant rates. In order to control the genome expansion during evolution, we generalize here the ...
Gregori Josep - - 2013
The microarray community has shown that the low reproducibility observed in gene expression-based biomarker discovery studies is partially due to relying solely on p-values to get the lists of differentially expressed genes. Their conclusions recommended complementing the p-value cutoff with the use of an effect-size criteria. The aim of this ...
Alsop Derek - - 2013
The acute toxicities and mechanisms of action of a variety of environmental contaminants were examined using zebrafish larvae (Danio rerio; 4-8 days post fertilization). Toxic interactions were observed between metals. For example, the addition of a sublethal level of nickel (15% of the LC50, one third of the LC01) to ...
Tian Hong - - 2013
Silver nanoparticles (AgNPs) have been widely used in commercial goods ranging from medical devices to home appliances. Their widespread application increase the risk related to their potential toxicity. Although several studies showed their acute hazardous effects on living animals, our understanding of chronic effects of AgNPs exposed by the environment ...
Thomas R Q - - 2013
Projections of future changes in land carbon (C) storage using biogeochemical models depend on accurately modeling the interactions between the C and nitrogen (N) cycles. Here, we present a framework for analyzing N limitation in global biogeochemical models to explore how C-N interactions of current models compare to field observations, ...
Rips Lance J - - 2013
This paper examines Piantadosi, Tenenbaum, and Goodman's (2012) model for how children learn the relation between number words ("one" through "ten") and cardinalities (sizes of sets with one through ten elements). This model shows how statistical learning can induce this relation, reorganizing its procedures as it does so in roughly ...
Thote Tanushree - - 2013
OBJECTIVE: Current histological scoring methods to evaluate efficacy of potential therapeutics for slowing or preventing joint degeneration are time-consuming and semi-quantitative in nature. Hence, there is a need to develop and standardize quantitative outcome measures to define sensitive metrics for studying potential therapeutics. The objectives of this study were to ...
Pisansky Marc T - - 2013
Iron deficiency (ID) during early life causes long-lasting detrimental cognitive sequelae, many of which are linked to alterations in hippocampus function, dopamine synthesis, and the modulation of dopaminergic circuitry by the hippocampus. These same features have been implicated in the origins of schizophrenia, a neuropsychiatric disorder with significant cognitive impairments. ...
Rudovic Ognjen - - 2013
We propose a method for head-pose invariant facial expression recognition that is based on a set of characteristic facial points. To achieve head-pose invariance, we propose the Coupled Scaled Gaussian Process Regression (CSGPR) model for head-pose normalization. In this model, we first learn independently the mappings between the facial points ...
Narinc Dogan - - 2013
In this study, long-term egg production was monitored in a Japanese quail flock, which had not undergone any genetic improvement, for 52 wk as of the age of sexual maturity. The study aimed to detect some traits with respect to egg production, to determine the cumulative hen-housed egg numbers, and ...
Wolc A - - 2013
Random regression models allow for analysis of longitudinal data, which together with the use of genomic information are expected to increase accuracy of selection, when compared with analyzing average or total production with pedigree information. The objective of this study was to estimate variance components for egg production over time ...
Li Xinhai - - 2013
Species distribution models have been used extensively in many fields, including climate change biology, landscape ecology and conservation biology. In the past 3 decades, a number of new models have been proposed, yet researchers still find it difficult to select appropriate models for data and objectives. In this review, we ...
Tan Jifu - - 2013
Prediction of nanoparticle (NP) distribution in a vasculature involves transport phenomena at various scales and is crucial for the evaluation of NP delivery efficiency. A combined particulate and continuum model is developed to model NP transport and delivery processes. In the particulate model ligand-receptor binding kinetics is coupled with Brownian ...
Weisbecker Hannah - - 2013
In a previous study we were able to accurately fit experimental data on arterial tissues at supra-physiological loads using a material model that accounts for softening/damage only in the portion of the model associated with the collagen fibers (Weisbecker et al., 2012). Naturally, this result leads to the hypothesis that ...
Harpold Adrian A - - 2013
Describing the distribution of aquatic habitats and the health of biological communities can be costly and time-consuming; therefore, simple, inexpensive methods to scale observations of aquatic biota to watersheds that lack data would be useful. In this study, we explored the potential of a simple "hydrogeomorphic" model to predict the ...
Maeng Jin Hee - - 2013
In this study, we examined rabbit gastric ulcer models that can serve as more clinically relevant models. Two types of ulcer model were studied: acetic acid-induced ulcers (AAU) and mucosal resection-induced ulcers (MRU). For AAU, rabbit gastric mucosa was exposed by median laparotomy and treated with bottled acetic acid. MRU ...
Starnini Michele - - 2013
Here we consider the topological properties of the integrated networks emerging from the activity-driven model [N. Perra et al., Sci. Rep. 2, 469 (2012)], a temporal network model recently proposed to explain the power-law degree distribution empirically observed in many real social networks. By means of a mapping to a ...
Withouck Martijn - - 2013
The perception of brightness of unrelated self-luminous colored stimuli of the same luminance has been investigated. The Helmholtz-Kohlrausch (H-K) effect, i.e., an increase in brightness perception due to an increase in saturation, is clearly observed. This brightness perception is compared with the calculated brightness according to six existing vision models, ...
Reddy Sheila M W SM Sustainability Science, The Nature Conservancy, 334 Blackwell St., Suite 300, Durham, North Carolina 27701-2394, USA. - - 2013
Market demand is often ignored or assumed to lead uniformly to the decline of resources. Yet little is known about how market demand influences natural resources in particular contexts, or the mediating effects of biological or institutional factors. Here, we investigate this problem by examining the Pacific red snapper (Lutjanus ...
Kreienkamp Amelia B AB Department of Chemistry, Wellesley College, Wellesley MA 02481, - - 2013
We analyze and suggest improvements to a recently developed approximate continuum-electrostatic model for proteins. The model, called BIBEE/I (boundary-integral based electrostatics estimation with interpolation), was able to estimate electrostatic solvation free energies to within a mean unsigned error of 4% on a test set of more than 600 proteins-a significant ...
Suleimenov Yerzhan - - 2013
Deciphering the mechanisms involved in gene regulation holds the key to understanding the control of central biological processes, including human disease, population variation, and the evolution of morphological innovations. New experimental techniques including whole genome sequencing and transcriptome analysis have enabled comprehensive modeling approaches to study gene regulation. In many ...
Araujo Sheila C - - 2013
ALK-5 (Activin-Like Kinase 5) is a biological receptor involved in a variety of pathological processes such as cancer and fibrosis. ALK-5 receptor propagates an intracellular signaling that forms a protein complex capable of reaching the nucleus and modulating the gene transcription. In the present study, comparative molecular field analysis (CoMFA) ...
Taylor Sean C - - 2013
Chemiluminescent western blotting has been in common practice for over three decades, but its use as a quantitative method for measuring the relative expression of the target proteins is still debatable. This is mainly due to the various steps, techniques, reagents, and detection methods that are used to obtain the ...
Moore Benjamin L - - 2013
Coarse-grained protein structure models offer increased efficiency in structural modeling, but these must be coupled with fast and accurate methods to revert to a full-atom structure. Here, we present a novel algorithm to reconstruct mainchain models from C traces. This has been parameterized by fitting Gaussian mixture models (GMMs) to ...
Jou Rong-Chang - - 2013
A triple-bounded dichotomous choice (TBDC) structure and Spike models are applied to investigate the amount of money Taiwan automobile drivers are willing to pay for five types of moving violations, including local street speeding, expressway and freeway speeding, red light running, right turn on red, and drink-driving. Face-to-face survey was ...
Holand Anna Marie - - 2013
Animal models are generalized linear mixed models (GLMM) used in evolutionary biology and animal breeding to identify the genetic part of traits. Integrated Nested Laplace Approximation (INLA) is a methodology for making fast non-sampling based Bayesian inference for hierarchical Gaussian Markov models. In this paper we demonstrate that the INLA ...
Siewert Elizabeth - - 2013
Although genome-wide expression data sets from multiple species are now more commonly generated, there have been few studies on how to best integrate this type of correlated data into models. Starting with a single-species, linear regression model that predicts transcription factor binding sites as a case study, we investigated how ...
Palumbo Giandomenico - - 2013
Abelian Chern-Simons-Maxwell theory can emerge from the bosonization of the (2+1)-dimensional Thirring model that describes interacting Dirac fermions. Here we show how the Thirring model manifests itself in the low energy limit of a two-dimensional tight-binding model of spinless fermions. To establish that, we employ a modification of Haldane's model, ...
Saito Tomohisa - - 2013
TP300 is a novel topoisomerase I inhibitor with neutropenia as a significant toxicity. We developed and evaluated a pharmacokinetic-pharmacodynamic (PK-PD) model, using data from Phase I and II trials to predict neutrophil decrease in patients treated with TP300. Plasma drug concentrations of TP300, its active form TP3076 and active metabolite ...
Ge Quansheng - - 2013
Recent shifts in phenology reflect the biological response to current climate change. Aiming to enhance our understanding of phenological responses to climate change, we developed, calibrated and validated spatio-temporal models of first leaf date (FLD) for 20 broadleaved deciduous plants in China. Using daily meteorological data from the Chinese Meteorological ...
Del Biondo Diego - - 2013
We present a numerical study of the slip link model introduced by Likhtman for describing the dynamics of dense polymer melts. After reviewing the technical aspects associated with the implementation of the model, we extend previous work in several directions. The dependence of the relaxation modulus with the slip link ...
Overmars Koen P - - 2013
In this paper we describe a methodology to model the impacts of policy measures within the Common Agricultural Policy (CAP) on farm production, income and prices, and on farmland biodiversity. Two stylised scenarios are used to illustrate how the method works. The effects of CAP measures, such as subsidies and ...
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