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Jones Daniel O B DO National Oceanography Centre, University of Southampton Waterfront Campus, European Way, Southampton, SO14 3ZH, - - 2013
Seafloor organisms are vital for healthy marine ecosystems, contributing to elemental cycling, benthic remineralization, and ultimately sequestration of carbon. Deep-sea life is primarily reliant on the export flux of particulate organic carbon from the surface ocean for food, but most ocean biogeochemistry models predict global decreases in export flux resulting ...
Posada-Izquierdo Guiomar D GD Department of Food Science and Technology, University of Cordoba, Campus de Rabanales, Edificio Darwin-C1, 14014 Córdoba, Spain. Electronic address: - - 2013
The purpose of this study was to evaluate and model the growth of Escherichia coli O157:H7 in fresh-cut lettuce submitted to a neutral electrolyzed water (NEW) treatment, packaged in passive modified atmosphere and subsequently stored at different temperatures (4, 8, 13, 16°C) for a maximum of 27days. Results indicated that ...
Shams Shiva S IASMA Research and Innovation Centre, Istituto Agrario di S. Michele all'Adige, Fondazione E. Mach, Via E. Mach 1, 38010 S. Michele all'Adige (Trento), Italy; Human and Environmental Toxicology Group, Department of Biology, University of Konstanz, P.O. Box X-918, D-78457 Konstanz, Germany. Electronic address: - - 2013
In this study, we investigated the kinetic aspects of the microcystin (MC) transfer from Planktothrix rubescens to Daphnia magna by carrying out exposure experiments in small simple mesocosms. We hypothesized that higher fractions of toxic cyanobacteria in the diet of grazers would shift the balance towards a greater than linear, ...
Abbasian Parandoush P Health Physics and Dosimetry Laboratory, Department of Energy Engineering and Physics, Amir Kabir University of Technology, Tehran, - - 2014
The main purpose of this work was to develop a pharmacokinetic model for the bone pain palliation agent Samarium-153 ethylenediamine tetramethylene phosphonate ([(153)Sm]-EDTMP) in normal rats to analyze the behavior of the complex. The use of compartmental analysis allows a mathematical separation of tissues and organs to determine the concentration ...
Sonne Christian C Department of Bioscience, Arctic Research Centre, Aarhus University, Denmark. Electronic address: - - 2013
Human exposure to persistent organic pollutants (POPs) and the potential health impact in the Arctic far from the emission sources have been highlighted in numerous studies. As a supplement to human POP biomonitoring studies, a physiologically based pharmacokinetic (PBPK) model was set up to estimate the fate of POPs in ...
Aher Rahul Balasaheb - - 2013
Both a development of resistance to artemisinin monotherapy and lack of effective vaccine against malaria have created the urgent need for the development of new and efficient antimalarial agents. In this background, we have developed here a linear discriminant analysis (LDA) model and a few 3D-pharmacophore models for the classification ...
Lee Jui-Huan JH Institute of Occupational Medicine and Industrial Hygiene, College of Public Health, National Taiwan University, Taipei, - - 2013
This study is conducted to characterize the intra-urban distribution of NOx and NO2; develop land use regression (LUR) models to assess outdoor NOx and NO2 concentrations, using the ESCAPE modeling approach with locally specific land use data; and compare NOx and NO2 exposures for children in the Taipei Metropolis by ...
Loerakker Sandra S Department of Biomedical Engineering, Eindhoven University of Technology, P.O. Box 513, 5600 MB , Eindhoven, The Netherlands, - - 2013
Collagen is the main load-bearing component of many soft tissues and has a large influence on the mechanical behavior of tissues when exposed to mechanical loading. Therefore, it is important to increase our understanding of collagen remodeling in soft tissues to understand the mechanisms behind pathologies and to control the ...
Zhao Guoliang G Faculty of Electronic Information and Electronic Engineering, Dalian University of Technology, Dalian 116024, China ; Modern Manufacture Engineering Center, Heilongjiang University of Science and Technology, Harbin 150022, - - 2013
This paper proposes new methodologies for the design of adaptive integral-sliding mode control. A tensor product model transformation based adaptive integral-sliding mode control law with respect to uncertainties and perturbations is studied, while upper bounds on the perturbations and uncertainties are assumed to be unknown. The advantage of proposed controllers ...
Shah Dhaval K DK Department of Pharmaceutical Sciences, University at Buffalo, The State University of New York, 452 Kapoor Hall, Buffalo, NY, 14260, - - 2013
We are investigating an inverse targeting strategy to reduce the dose limiting systemic toxicities resultant from intraperitoneal administration of topotecan, a model chemotherapeutic drug. This approach utilizes systemic co-administration of anti-topotecan antibodies to alter the plasma and tissue disposition kinetics of topotecan. To better predict the effects of 8C2, a ...
Wijesekara Gayan Nishad GN Department of Geomatics Engineering, University of Calgary, Calgary, AB, Canada, - - 2013
The Elbow River watershed in Alberta covers an area of 1,238 km(2) and represents an important source of water for irrigation and municipal use. In addition to being located within the driest area of southern Canada, it is also subjected to considerable pressure for land development due to the rapid ...
Zhang Yejia Y Departments of ‡Orthopedic Surgery, †Biochemistry *Physical Medicine & Rehabilitation, Rush University Medical Center, Chicago, IL; [Black up-pointing triangle]Department of Orthopedic Surgery, Second Hospital of Xiangya, Central South University, Hunan, P. R. China; ΔQujing No. 1 Hospital, Orthopedic Department, Yunnan Province, PR China; #Department of Physical Medicine and Rehabilitation, Perelman School of Medicine, University of Pennsylvania, and Philadelphia VA Medical Center, Philadelphia, - - 2013
Study Design. Histological features of the intervertebral disc/endplate interface were analyzed.Objective. To define cartilaginous and bony vertebral endplate in commonly used laboratory animals and compare with that of the humans.Summary of Background Data. Endplates are crucial for the IVD nutrient supply: the IVDs have limited blood supply; most nutrients diffuse ...
Ishak Mustapha M Department of Physics, The University of Texas at Dallas, Richardson, Texas 75083, - - 2013
Probes of cosmic expansion constitute the main basis for arguments to support or refute a possible apparent acceleration due to different expansion rates in the Universe as described by inhomogeneous cosmological models. We present in this Letter a separate argument based on results from an analysis of the growth rate ...
Sun Xian-qiang XQ 1] Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China [2] Division of Theoretical Chemistry and Biology, School of Biotechnology, KTH Royal Institute of Technology, S-106 91 Stockholm, - - 2014
To develop a novel 3D-QSAR approach for study of the epidermal growth factor receptor tyrosine kinase (EGFR TK) and its inhibitors. One hundred thirty nine EGFR TK inhibitors were classified into 3 clusters. Ensemble docking of these inhibitors with 19 EGFR TK crystal structures was performed. Three protein structures that ...
Thomas Trayder - - 2013
We have developed homology models of the acetylcholine muscarinic receptors M1R-M5R, based on the β2-adrenergic receptor crystal as the template. This is the first report of homology modeling of all five subtypes of acetylcholine muscarinic receptors with binding sites optimized for ligand binding. The models were evaluated for their ability ...
Chen Tianju T Key Laboratory of Biofuels, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, 189 Songling Road, Qingdao 266101, PR - - 2013
The gasification kinetic analysis of the three pseudocomponents (hemicellulose, cellulose and lignin) of biomass decomposition in the agent of CO2 were investigated. The Multi-peaks method was used to fit the Gaussian distribution model of DTG curves. The Friedman method was used to estimate the effective Eα, and the master plot ...
Sweeney Lisa M LM Henry M. Jackson Foundation for the Advancement of Military Medicine, Naval Medical Research Unit Dayton, Wright-Patterson AFB, OH - - 2013
The ten Berge model, also known as the toxic load model, is an empirical approach in hazard assessment modeling for estimating the relationship between the inhalation toxicity of a chemical and the exposure duration. The toxic load (TL) is normally expressed as a function of vapor concentration (C) and duration ...
Dastoor Ashu P - - 2013
High levels of mercury in marine mammals threaten the health of Arctic inhabitants. Whether the Arctic Ocean (AO) is a sink or a source of atmospheric mercury is unknown. Given the paucity of observations in the Arctic, models are useful in addressing this question. GEOS-Chem and GRAHM, two complex numerical ...
Faraj Chafika - - 2013
In Morocco, the main strategies of leishmaniasis vector control are based on environmental modifications. Use of local residual indoor spraying with synthetic pyrethroids is often envisaged. The need to evaluate this control method is essential. The current study was conducted to determine the efficacy of an alphacypermethrin IRS program against ...
Taffetani M M Department of Chemistry, Materials and Chemical Engineering, Laboratory of Biological Structure Mechanics (LaBS), Politecnico di Milano, Milano, Italy. Electronic address: - - 2013
Articular cartilage is a soft hydrated tissue that facilitates proper load transfer in diarthroidal joints. The mechanical properties of articular cartilage derive from its structural and hierarchical organization that, at the micrometric length scale, encompasses three main components: a network of insoluble collagen fibrils, negatively charged macromolecules and a porous ...
Tang Min M Ewha Womans University, - - 2013
We present fast CCD algorithm for general rigid and articulated models based on conservative advancement. We have implemented the CCD algorithm with two different acceleration techniques which can handle rigid models, and have extended one of them to articulated models. The resulting algorithms take a few milliseconds for rigid models ...
Waran Vicknes - - 2013
The advent of multimaterial 3D printers allows the creation of neurosurgical models of a more realistic nature, mimicking real tissues. The authors used the latest generation of 3D printer to create a model, with an inbuilt pathological entity, of varying consistency and density. Using this model the authors were able ...
Poniatowski Lauren H - - 2013
Background: The objective was to determine the acceptability and preliminary construct validity for a high-fidelity synthetic renal pelvis/ureter tissue analogue model for use as a simulation model for training laparoscopic pyeloplasty. Methods: The pyeloplasty model was designed with incorporated assessment lines for use in post-task Black Light Assessment of Surgical ...
Grenier Stephanie S Laboratory for Soft Tissue Research, Tissue Engineering, Regeneration and Repair Program, The Hospital for Special Surgery, New York, NY 10021, United States. Electronic address: - - 2013
The objective of this study was to develop an in vitro cartilage degradation model that emulates the damage seen in early-stage osteoarthritis. To this end, cartilage explants were collagenase-treated to induce enzymatic degradation of collagen fibers and proteoglycans at the articular surface. To assess changes in mechanical properties, intact and ...
Tobin Chase A - - 2013
The commonly used methods to quantify axon numbers and mean area include manual and semiautomated procedures. The authors introduce a new fully automated method of morphometric analysis using ImageJ and Paint.net software to improve efficiency and accuracy. A total of six rat sciatic nerves were examined for their axon numbers ...
Pancheri F Q FQ Department of Mechanical Engineering, Tufts University, Medford, MA, United - - 2013
In this paper we propose a constitutive model to analyze in-plane extension of goat fascia lata. We first perform a histological analysis of the fascia that shows a well-organized bi-layered arrangement of undulated collagen fascicles oriented along two well defined directions. To develop a model consistent with the tissue structure ...
Watters Orla - - 2013
The technical advances made in microscopy have been matched by an increase in the application of fluorescent microscopy to answer scientific questions. While analysis of fluorescent microscopy images represents a powerful tool, one must be aware of the potential pitfalls. Frequently, the analysis methods applied involve at least some manual ...
Oakes Jessica M - - 2013
Image-based in silico modeling tools provide detailed velocity and particle deposition data. However, care must be taken when prescribing boundary conditions to model lung physiology in health or disease, such as in emphysema. In this study, the respiratory resistance and compliance were obtained by solving an inverse problem; a 0D ...
Su Shiliang - - 2013
A comparison of different transportation route types and their combined effects on landscape diversity was conducted within Tiaoxi watershed (China) between 1994 and 2005. Buffer analysis and Mann-Kendall's test were used to quantify the relationships between distance from transportation routes (railway, highway, national, and provincial road) and a family of ...
Pardal David - - 2013
Abstract Resveratrol, a polyphenolic phytoalexin found in many plants, has been reported to have antiobesogenic effects in several animal and in vitro models. Zebrafish present several technical advantages that place them at an interesting, halfway point between in vitro and rodent models. The aim of the present work was to ...
Bozkurt Hayriye H Department of Food Science and Technology, The University of Tennessee, 2600 River Drive, Knoxville, TN 37996-4591, - - 2014
Control of seafood-associated norovirus outbreaks has become an important priority for public health authorities. Due to the absence of human norovirus infectivity assays, cultivable surrogates such as feline calicivirus (FCV-F9) and murine norovirus (MNV-1) have been used to begin to understand their thermal inactivation behavior. In this study, the effect ...
Li Keqiang - - 2013
With the recent development of society and economy in the cities of Huludao and Jinzhou, Liaoning Province, China, environment and ecosystem problems have become increasingly serious in Jinzhou Bay, China, because of the increasing amount of heavy metal pollutants being discharged. To solve these problems, a water quality model of ...
Capogrosso Marco - - 2013
Epidural electrical stimulation (EES) of lumbosacral segments can restore a range of movements after spinal cord injury. However, the mechanisms and neural structures through which EES facilitates movement execution remain unclear. Here, we designed a computational model and performed in vivo experiments to investigate the type of fibers, neurons, and ...
Tong Peijian - - 2013
Ethnopharmacological relevance: Fuzi is an effective but toxic traditional Chinese medicine (TCM) derived from Aconitum carmichaeli. In our previous study, detoxicated Fuzi (d-Fuzi) has been originally developed with no toxicity but significant efficacy. However, whether d-Fuzi can be used for therapy of osteoarthritis (OA), remain unknown.Materials and methods: Severe OA ...
Reutlinger Christoph C Institute for Surgical Technology and Biomechanics, University of Bern, Switzerland. Electronic address: - - 2013
Numerical models of the intervertebral disc, which address mechanical questions commonly make use of the difference in water content between annulus and nucleus, and thus fluid and solid parts are separated. Despite this simplification, models remain complex due to the anisotropy and nonlinearity of the annulus and regional variations of ...
Bordner Andrew J - - 2013
Despite the importance of a thermodynamically stable structure with a conserved fold for protein function, almost all evolutionary models neglect site-site correlations that arise from physical interactions between neighboring amino acid sites. This is mainly due to the difficulty in formulating a computationally tractable model since rate matrices can no ...
Suo Chen - - 2013
RNA-sequencing technologies provide a powerful tool for expression analysis at gene and isoform level, but accurate estimation of isoform abundance is still a challenge. Standard assumption of uniform read intensity would yield biased estimates when the read intensity is in fact non-uniform. The problem is that, without strong assumptions, the ...
Bourne Roger M - - 2013
To compare the theoretical information content of four popular models of diffusion-weighted signal attenuation. Four whole prostates were imaged fresh unfixed and fixed at 9.4T. Biexponential, kurtosis, stretched exponential, and monoexponential models were ranked using Akaike's Information Criterion (AIC) with validation by a leave-one-out test of model prediction error. For ...
Hindmarch C C T CC University of Bristol, The Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, Bristol, - - 2013
The supraoptic nucleus (SON) is part of the central osmotic circuitry that synthesises the hormone vasopressin (Avp) and transports it to terminals in the posterior lobe of the pituitary. Following osmotic stress such as dehydration, this tissue undergoes morphological, electrical and transcriptional changes to facilitate the appropriate regulation and release ...
Pavlov Michael Y - - 2013
Bacterial populations growing in a changing world must adjust their proteome composition in response to alterations in the environment. Rapid proteome responses to growth medium changes are expected to increase the average growth rate and fitness value of these populations. Little is known about the dynamics of proteome change, e.g., ...
Baum-Snow Nathaniel N Brown University & - - 2013
Between 1979 and 2007 a strong positive monotonic relationship between wage inequality and city size has developed. This paper investigates the links between this emergent city size inequality premium and the contemporaneous nationwide increase in wage inequality. After controlling for the skill composition of the workforce across cities of different ...
Wang Chen-Pin CP Department of Epidemiology and Biostatistics, University of Texas Health Science Center, San Antonio TX, 78229, - - 2013
Wang and Ghosh (2011) proposed a Kullback-Leibler divergence (KLD) which is asymptotically equivalent to the KLD by Goutis and Robert (1998) when the reference model (in comparison with a competing fitted model) is correctly specified and when certain regularity conditions hold true. While properties of the KLD by Wang and ...
Scully Robert R - - 2013
Abstract The pulmonary toxicity of airborne lunar dust was assessed in rats exposed by nose-only inhalation to 0, 2.1, 6.8, 20.8 and 60.6 mg/m3 of respirable size lunar dust. Rats were exposed for 6 h/d, 5 d/week, for 4 weeks (120 h). Biomarkers of toxicity were assessed in bronchial alveolar lavage fluid (BALF) collected ...
Hébert-Dufresne Laurent L Département de Physique, de Génie Physique, et d'Optique, Université Laval, Québec (Québec), Canada G1V - - 2013
The k-core decomposition of a network has thus far mainly served as a powerful tool for the empirical study of complex networks. We now propose its explicit integration in a theoretical model. We introduce a hard-core random network (HRN) model that generates maximally random networks with arbitrary degree distribution and ...
Motallebi Sadegh S Department of Computer Engineering, Sharif University of Technology, Tehran, - - 2013
Real networks exhibit nontrivial topological features, such as heavy-tailed degree distribution, high clustering, and small-worldness. Researchers have developed several generative models for synthesizing artificial networks that are structurally similar to real networks. An important research problem is to identify the generative model that best fits to a target network. In ...
Visser Anniek K D AK Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Centre Groningen, Hanzeplein 1, 9700 RB, Groningen, The Netherlands, - - 2013
Preclinical positron emission tomography studies are important to follow disease progression and develop new pharmacological agents. We investigated whether kinetic modeling of 5-HT2A tracer [(11)C]MDL 100907 is possible in rats. Kinetic modeling with either metabolite-corrected plasma curve or with the cerebellum as a reference tissue resulted in a good correlation ...
Lee Taewoo - - 2013
Purpose: Intensity-modulated radiation therapy (IMRT) treatment planning typically combines multiple criteria into a single objective function by taking a weighted sum. The authors propose a statistical model that predicts objective function weights from patient anatomy for prostate IMRT treatment planning. This study provides a proof of concept for geometry-driven weight ...
Hossain Ahmed - - 2013
Abstract MicroRNAs (miRNAs) are short non-coding RNAs that play critical roles in numerous cellular processes through post-transcriptional functions. The aberrant role of miRNAs has been reported in a number of diseases. A robust computational method is vital to discover novel miRNAs where level of noise varies dramatically across the different ...
Tung David D BioMed Valley Discoveries, Kansas City, - - 2013
Trilostane was identified in an in vivo screen of compounds in a lipopolysaccharide model of inflammation to support a repurposing effort. There is no previous documentation of any anti-inflammatory effects of trilostane. The aim of this study was to elucidate the novel pharmacologic activity of trilostane in a series of ...
Asano Yoshihide - - 2013
Systemic sclerosis (SSc) is a multisystem connective tissue disease characterized by three cardinal features: immunological abnormalities, vasculopathy, and fibrosis of skin and certain internal organs. Although several animal models recapitulating selected aspects of SSc have been reported, the absence of models fulfilling the full clinical picture of SSc has hindered ...
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