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Falzon L C LC Department of Population Medicine, Ontario Veterinary College, University of Guelph, Guelph, ON, N1G 2 W1, Canada, - - 2014
This study compared results obtained with five different fecal egg count reduction (FECR) calculation methods for defining resistance to ivermectin, fenbendazole, and levamisole in gastrointestinal nematodes of sheep in a temperate continental climate: FECR1 and FECR2 used pre- and posttreatment fecal egg count (FEC) means from both treated and control ...
Valeri Linda L Department of Biostatistics and Epidemiology, Harvard School of Public Health, 655 Huntington avenue, Boston, MA 02115, - - 2014
Mediation analysis serves to quantify the effect of an exposure on an outcome mediated by a certain intermediate and to quantify the extent to which the effect is direct. When the mediator is misclassified, the validity of mediation analysis can be severely undermined. The contribution of the present work is ...
Goodwin R Andrew RA Environmental Laboratory, US Army Engineer Research and Development Center, Portland, OR - - 2014
Navigating obstacles is innate to fish in rivers, but fragmentation of the world's rivers by more than 50,000 large dams threatens many of the fish migrations these waterways support. One limitation to mitigating the impacts of dams on fish is that we have a poor understanding of why some fish ...
Ikard S J SJ Department of Geophysics, Colorado School of Mines, Green Center, Golden, - - 2014
A hydrogeophysical survey is performed at small earthen dam that overlies a confined aquifer. The structure of the dam has not shown evidence of anomalous seepage internally or through the foundation prior to the survey. However, the surface topography is mounded in a localized zone 150 m downstream, and groundwater discharges ...
Lorthois Sylvie S CNRS; IMFT (Institut de Mécanique des Fluides de Toulouse), Allée Camille Soula, F-31400 Toulouse, France; Université de Toulouse; INPT, UPS; IMFT (Institut de Mécanique des Fluides de Toulouse), Allée Camille Soula, F-31400 Toulouse, France. Electronic address: - - 2014
One the one hand, capillary permeability to water is a well-defined concept in microvascular physiology, and linearly relates the net convective or diffusive mass fluxes (by unit area) to the differences in pressure or concentration, respectively, that drive them through the vessel wall. On the other hand, the permeability coefficient ...
Blurton Steven P SP Institute for Psychology, University of Regensburg, Universitätsstr. 31, 93050, Regensburg, Germany, - - 2014
In multisensory research, faster responses are commonly observed when multimodal stimuli are presented, as compared to unimodal target presentations. This so-called redundant-signals effect can be explained by several frameworks, including separate-activation and coactivation models. The redundant-signals effect has been investigated in a large number of studies; however, most of those ...
Chust Guillem G AZTI-Tecnalia, Marine Research Division, Herrera kaia portualdea z/g, 20110, Pasaia, - - 2014
Ocean warming can modify the ecophysiology and distribution of marine organisms, and relationships between species, with nonlinear interactions between ecosystem components potentially resulting in trophic amplification. Trophic amplification (or attenuation) describe the propagation of a hydroclimatic signal up the food web, causing magnification (or depression) of biomass values along one ...
Vanderweele Tyler J TJ From the aDepartments of Epidemiology and Biostatistics, Harvard School of Public Health, Boston, MA; and bDepartment of Applied Mathematics, Computer Science, and Statistics, University of Ghent, Ghent, - - 2014
Methods from causal mediation analysis have generalized the traditional approach to direct and indirect effects in the epidemiologic and social science literature by allowing for interaction and nonlinearities. However, the methods from the causal inference literature have themselves been subject to a major limitation, in that the so-called natural direct ...
Xue Qian Q Department of Mechanical Engineering, University of Maine, Orono, Maine, - - 2014
A direct numerical simulation of flow-structure interaction is carried out in a subject-specific larynx model to study human phonation under physiological conditions. The simulation results compare well to the established human data. The resulting glottal flow and waveform are found to be within the normal physiological ranges. The effects of ...
Kaufmann Vander V Doutor em Engenharia Recursos Hídricos e Saneamento Ambiental IPH/UFRGS, Rua Jequié, 74, Itoupava Seca, CEP 89030-350, Blumenau, SC, Brazil. Electronic address: - - 2014
Intense rainfall adversely affects agricultural areas, causing transport of pollutants. Physically-based hydrological models to simulate flows of water and chemical substances can be used to help decision-makers adopt measures which reduce such problems. The purpose of this paper is to evaluate the performance of SWAP and ANIMO models for simulating ...
Zhang Yili Y Department of Neurobiology and Anatomy, The University of Texas Medical School at Houston, Houston, Texas, United States of - - 2014
Cellular functions and responses to stimuli are controlled by complex regulatory networks that comprise a large diversity of molecular components and their interactions. However, achieving an intuitive understanding of the dynamical properties and responses to stimuli of these networks is hampered by their large scale and complexity. To address this ...
van Strien Maarten J - - 2014
For conservation managers, it is important to know whether landscape changes lead to increasing or decreasing gene flow. Although the discipline of landscape genetics assesses the influence of landscape elements on gene flow, no studies have yet used landscape-genetic models to predict gene flow resulting from landscape change. A species ...
Eiting Thomas P TP University of Massachusetts Amherst, United - - 2014
The olfactory recess-a blind pocket at the back of the nasal airway-is thought to play an important role in mammalian olfaction by sequestering air outside of the main airstream, thus giving odorants time to re-circulate. Several studies have shown that species with large olfactory recesses tend to have a well-developed ...
Hitit Zeynep Yilmazer ZY Faculty of Engineering, Department of Chemical Engineering, Ankara University, Tandogan, 06100, Ankara, Turkey, - - 2014
A detailed system identification procedure and self-tuning generalized minimum variance (STGMV) control of glucose concentration during the aerobic fed-batch yeast growth were realized. In order to determine the best values of the forgetting factor (λ), initial value of the covariance matrix (α), and order of the Auto-Regressive Moving Average with ...
Hasegawa Chihiro C Pharmacokinetic Research Laboratories, Ono Pharmaceutical Co. Ltd., Tsukuba, Ibaraki, Japan; Department of Clinical Pharmacokinetics, Graduate School of Pharmaceutical Sciences, Kyushu University, Higashi-ku, Fukuoka, - - 2014
ONO-5334, a selective inhibitor of cathepsin K, is a potential new treatment for osteoporosis. The objectives of this modeling study were to (1) develop exposure-response (E-R) models to relate ONO-5334 exposure to bone mineral density (BMD), (2) predict BMD responses to various doses of ONO-5334 for both immediate release tablet ...
Moran Emily V EV ETH Zurich, Universitatstrasse 16, 8092, Zurich, - - 2014
Biologists have recently devoted increasing attention to the role of rapid evolution in species' responses to environmental change. However, it is still unclear what evolutionary responses should be expected, at what rates, and whether evolution will save populations at risk of extinction. The potential of biological invasions to provide useful ...
Ghosh Pranay P IBG-1: Biotechnology, Forschungszentrum Jülich, - - 2014
Membrane chromatography (MC) systems are finding increasing use in downstream processing trains for therapeutic proteins due to the unique mass-transfer characteristics they provide. As a result, there is increased need for model-based methods to scale up MC units using data collected on a scaled-down unit. Here, a strategy is presented ...
Kihara Yasuyuki Y Department of Chemistry and Biochemistry and Pharmacology, School of Medicine, University of California at San Diego, La Jolla, California; Department of Bioengineering, University of California at San Diego, La Jolla, - - 2014
Eicosanoids, including prostaglandins (PG) and leukotrienes, are lipid mediators derived from arachidonic acid. A quantitative and biochemical level understanding of eicosanoid metabolism would aid in understanding the mechanisms that govern inflammatory processes. Here, we present a combined experimental and computational approach to understanding the biochemical basis of eicosanoid metabolism in ...
Sturchio Neil C NC Department of Earth and Environmental Sciences, University of Illinois at Chicago, Chicago, IL 60607, USA. Electronic address: - - 2014
The Waste Isolation Pilot Plant (WIPP) in New Mexico is the first geologic repository for disposal of transuranic nuclear waste from defense-related programs of the US Department of Energy. It is constructed within halite beds of the Permian-age Salado Formation. The Culebra Dolomite, confined within Rustler Formation evaporites overlying the ...
Ortega Eva María EM Residencia Universitaria Oblatas, Murcia, 30001 SPAIN. Electronic address: - - 2014
This article concerns the analysis of a stochastic model that we propose for the population that generates a response (response measure) to the dose with the multi-stage model. The parameter uncertainty is dealt with via random dose and random size of the population at risk. The response measure is modeled ...
Beavers Gracie A GA Georgia State - - 2014
Shabani, Carr, and Petursdottir (2009) examined the effects of a response-response relation (effort) on the development of a response-class hierarchy using a laboratory model. Response-reinforcer relations may have similar influences. Using a similar translational approach, we examined the effects of reinforcer rate, quality, delay, and magnitude in a series of ...
Müller Esther E EMPA, Swiss Federal Laboratories for Materials Science and Technology , Technology and Society Laboratory, Lerchenfeldstrasse 5, CH-9014 St. Gallen, - - 2014
Dynamic material flow analysis (MFA) is a frequently used method to assess past, present, and future stocks and flows of metals in the anthroposphere. Over the past fifteen years, dynamic MFA has contributed to increased knowledge about the quantities, qualities, and locations of metal-containing goods. This article presents a literature ...
Huiliñir Cesar C Departamento de Ingeniería Química, Universidad de Santiago de Chile, Casilla 442, Correo 2, Santiago, Chile. Electronic address: - - 2014
This study focuses on the kinetics of volatile solids (VS) biodegradation of the biodrying process using pulp and paper secondary sludge. The experiments were carried out with air-flow rates of 0.51, 1.61, 3.25 and 5.26L/minkgVS) and initial moisture content of 64-66% w.b. Using five kinetic models and a nonlinear regression ...
Jiang Xiaoqi X Division of Biostatistics, German Cancer Research Center, Im Neuenheimer Feld, 280, 69120 Heidelberg, - - 2014
Dose-response studies are performed to investigate the potency of a compound. EC50 is the concentration of the compound that gives half-maximal response. Dose-response data are typically evaluated by using a log-logistic model that includes EC50 as one of the model parameters. Often, more than one experiment is carried out to ...
Ma Dehua D School of Environment, Tsinghua University, Beijing, 100084, - - 2014
To date, toxicological studies of endocrine disrupting chemicals (EDCs) have typically focused on single chemical exposures and associated effects. However, exposure to EDCs mixtures in the environment is common. Antiandrogens represent a group of EDCs, which draw increasing attention due to their resultant demasculinization and sexual disruption of aquatic organisms. ...
Zaehle Sönke S Biogeochemical Integration Department, Max Planck Institute for Biogeochemistry, Hans-Knöll-Str. 10, D-07745, Jena, - - 2014
We analysed the responses of 11 ecosystem models to elevated atmospheric [CO2 ] (eCO2 ) at two temperate forest ecosystems (Duke and Oak Ridge National Laboratory (ORNL) Free-Air CO2 Enrichment (FACE) experiments) to test alternative representations of carbon (C)-nitrogen (N) cycle processes. We decomposed the model responses into component processes ...
Sobel James M JM Department of Plant Biology, Ecology, Evolutionary Biology & Behavior Program, Michigan State University, East Lansing, MI, 48824; Department of Biological Sciences, Binghamton University, State University of New York, Binghamton, NY, 13902. - - 2014
Understanding the evolution of reproductive isolation is tantamount to describing the origin of species. Therefore, a primary goal in evolutionary biology is to identify which reproductive barriers are most important to the process. To achieve this goal, the strength of multiple forms of isolation must be compared in an equivalent ...
Krings Gautier M GM Institute for Information and Communication Technologies, Electronics and Applied Mathematics, Université catholique de Louvain, Louvain-la-Neuve, Belgium ; Real Impact Analytics Belgium, Brussels, - - 2014
We study the ever more integrated and ever more unbalanced trade relationships between European countries. To better capture the complexity of economic networks, we propose two global measures that assess the trade integration and the trade imbalances of the European countries. These measures are the network (or indirect) counterparts to ...
Eckel Sandrah P SP Department of Preventive Medicine, University of Southern California, Los Angeles, California, United States of - - 2014
The fractional concentration of exhaled nitric oxide (FeNO) is a biomarker of airway inflammation that is being increasingly considered in clinical, occupational, and epidemiological applications ranging from asthma management to the detection of air pollution health effects. FeNO depends strongly on exhalation flow rate. This dependency has allowed for the ...
Lim H-S HS Department of Clinical Pharmacology and Therapeutics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, - - 2014
Vancomycin is the drug of choice for methicillin-resistant Staphylococcus aureus (MRSA) infection and shows time-dependent bacterial killing. The current study evaluated the pharmacokinetics (PK) and pharmacodynamics (PD) of vancomycin and explored its optimal dosing regimens by modeling and simulation. Pharmacokinetics study was performed for 20 patients who were treated with ...
Coates L C LC LIMM Division of Rheumatic and Musculoskeletal Disease and NIHR Leeds Musculoskeletal Biomedical Research Unit, University of Leeds, Leeds, - - 2014
The CONTEST study was carried out in dermatology clinics only. As they point out there would be little point in administering these instruments in rheumatology clinics. The low response rate is disappointing but reflects the likely response to the use of such tools in clinical practice. We would indicate that ...
Esposito Emilio Xavier EX exeResearch LLC , 32 University Drive, East Lansing, Michigan 48823, United - - 2014
The inactivation of acetylcholinesterase (AChE) by organophosphorus agent (OP) compounds is a serious problem regardless of how the individual was exposed. The reactivation of OP-inactivated AChE is dependent on the OP conjugate, and commonly a specific oxime is better at reactivating a specific OP conjugate than several diverse OP conjugates. ...
Ajčević M M Department of Engineering and Architecture, University of Trieste, Trieste, - - 2014
Tracheal tubes (TT) are used in clinical practice to connect an artificial ventilator to the patient's airways. It is important to know the pressure used to overcome tube impedance to avoid lung injury. Although high-frequency percussive ventilation (HFPV) has been increasingly used, the mechanical behavior of TT under HFPV has ...
Wilson Ander A Department of Statistics, North Carolina State University, Raleigh, North Carolina, - - 2014
High-throughput screening (HTS) of environmental chemicals is used to identify chemicals with high potential for adverse human health and environmental effects from among the thousands of untested chemicals. Predicting physiologically relevant activity with HTS data requires estimating the response of a large number of chemicals across a battery of screening ...
Zhao Liang L College of Food Science and Nutritional Engineering, China Agricultural University, National Engineering Research Center for Fruit & Vegetable Processing, Key Laboratory of Fruit & Vegetable Processing, Ministry of Agriculture, Beijing 100083, P.R. - - 2014
The inactivation effects of high hydrostatic pressure (HHP) (350MPa/10min, 400MPa/4min and 500MPa/2min) with homogenization (20MPa/2min), nisin (100IU/mL) and decompression time (<3s and 7-8s) on naturally occurring microbiota in cucumber juice were investigated. Initial concentration of yeasts and molds (Y&M) was 5.6×10(3)-2.4×10(4)CFU/mL, and total plate count (TPC) was 1.0×10(5)-3.5×10(5)CFU/mL. Y&M were ...
Huang Shuangbing S a Institute of Hydrogeology and Environmental Geology , Chinese Academy of Geological Sciences , Shijiazhuang , PR - - 2014
The effects of various geochemical processes on arsenic enrichment in a high-arsenic aquifer at Jianghan Plain in Central China were investigated using multivariate models developed from combined adaptive neuro-fuzzy inference system (ANFIS) and multiple linear regression (MLR). The results indicated that the optimum variable group for the AFNIS model consisted ...
Spicer John I JI Marine Biology and Ecology Research Centre, School of Marine Science and Engineering, Plymouth University, Drake Circus, Plymouth PL4 8AA, - - 2014
Hypoxia (low O2) is a common and natural feature of many marine environments. However, human-induced hypoxia has been on the rise over the past half century and is now recognised as a major problem in the world's seas and oceans. Whilst we have information on how marine invertebrates respond physiologically ...
Penn R R Faculty of Civil and Environmental Engineering, Technion - Israel Institute of Technology, Haifa 32000, Israel E-mail: - - 2014
Onsite greywater reuse (GWR) and installation of water-efficient toilets (WETs) reduce urban freshwater demand and thus enhance urban water use sustainability. Research on GWR and WETs has generally overlooked their potential effects on municipal sewer systems: GWR and WETs affect the flow regime in sewers, and consequently also influence gross ...
Han Sung Wan SW Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, - - 2014
In a smoothing spline model with unknown change-points, the choice of the smoothing parameter strongly influences the estimation of the change-point locations, and the function at the change-points. In a tumor biology example, where change-points in blood flow in response to treatment were of interest, choosing the smoothing parameter based ...
Kodama Tatsuhiro T Formulation Technology Research Laboratories, Daiichi Sankyo Co., - - 2014
The purpose of this study was to develop a novel simulation program to accurately predict the maximum product temperature and the primary drying time in lyophilization using the predictive model for dry layer resistance, which is the resistance of dried cake against water vapor flow. Ten percent sucrose aqueous solution ...
Logan Gordon D GD Department of Psychology, Vanderbilt - - 2014
Response inhibition is an important act of control in many domains of psychology and neuroscience. It is often studied in a stop-signal task that requires subjects to inhibit an ongoing action in response to a stop signal. Performance in the stop-signal task is understood as a race between a go ...
Hatcher Melanie J MJ School of Biology, University of Leeds, , Leeds, West Yorkshire, - - 2014
Parasites play pivotal roles in structuring communities, often via indirect interactions with non-host species. These effects can be density-mediated (through mortality) or trait-mediated (behavioural, physiological and developmental), and may be crucial to population interactions, including biological invasions. For instance, parasitism can alter intraguild predation (IGP) between native and invasive crustaceans, ...
Zhou Xiaoke X 0000-0002-1149-729X School of Computer Science and Technology, Soochow University, Shizi Street No. 1, Suzhou, Jiangsu 215006, - - 2014
Traffic problems often occur due to the traffic demands by the outnumbered vehicles on road. Maximizing traffic flow and minimizing the average waiting time are the goals of intelligent traffic control. Each junction wants to get larger traffic flow. During the course, junctions form a policy of coordination as well ...
Elías-Maxil J A JA Department of Water Management, Delft University of Technology, Stevinweg 1, 2628 CN Delft, The Netherlands E-mail: - - 2014
In order to evaluate the feasibility of installing decentralised installations for wastewater reuse in cities, information about flows at specific spots of a sewer is needed. However, measuring intermittent flows in partially filled conduits is a technical task which is sometimes difficult to accomplish. This paper describes a method to ...
Lozano Norka B H NB Instituto de Química de São Carlos, USP, São Carlos (SP), 13566-590, Brazil. - - 2014
Chemometric pattern recognition techniques were employed in order to obtain Structure-Activity Relationship (SAR) models relating the structures of a series of adenosine compounds to the affinity for glyceraldehyde 3-phosphate dehydrogenase of Leishmania mexicana (LmGAPDH). A training set of 49 compounds was used to build the models and the best ones ...
Aly Aly Mousaad AM 0000-0002-1253-139X Department of Civil and Environmental Engineering, Louisiana State University, 3513D Patrick Franck Taylor Hall, Baton Rouge, LA 70803, - - 2014
Atmospheric turbulence results from the vertical movement of air, together with flow disturbances around surface obstacles which make low- and moderate-level winds extremely irregular. Recent advancements in wind engineering have led to the construction of new facilities for testing residential homes at relatively high Reynolds numbers. However, the generation of ...
Teske Sondra S SS Department of Civil, Architectural, and Environmental Engineering, Drexel University, Philadelphia, PA, - - 2013
The effect of bioaerosol size was incorporated into predictive dose-response models for the effects of inhaled aerosols of Francisella tularensis (the causative agent of tularemia) on rhesus monkeys and guinea pigs with bioaerosol diameters ranging between 1.0 and 24 μm. Aerosol-size-dependent models were formulated as modification of the exponential and ...
Meng Lingpeng L Department of Control Science and Engineering, Tongji University, Shanghai 201804, China ; Institute of Urban Construction and Emergency Management, Tongji University, Shanghai 200092, - - 2013
This paper is concerned with the effect of capacity constraints on the locations of terror response facilities. We assume that the state has limited resources, and multiple facilities may be involved in the response until the demand is satisfied consequently. We formulate a leader-follower game model between the state and ...
Chen Chen C Key Laboratory of Agro-Product Quality and Safety of Ministry of Agriculture, Institute of Quality Standards and Testing Technology for Agro-Products, Chinese Academy of Agricultural Sciences, Beijing, 100081, - - 2013
Mixtures of organophosphate (OP) and carbamate (CB) insecticides are commonly detected in freshwater habitats. These insecticides inhibit the activity of acetylcholinesterase (AChE) and have potential to interfere with behaviors that may be essential for survival of species. Although the effects of individual anticholinesterase insecticides on aquatic species have been studied ...
Tao Lin L Department of Gastroenterology, the First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, PR - - 2013
The diagnosis of tuberculosis (TB) ascites using standard diagnostic tools is difficult. The aim of the present meta-analysis was to establish the overall diagnostic accuracy of adenosine deaminase (ADA) levels in ascites for diagnosing TB ascites. A systematic review was performed of English language publications prior to April 2013. Sensitivity, ...
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