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Chaosakul Thitirat T a Environmental Engineering and Management, School of Environment, Resources and Development, Asian Institute of Technology , Bangkok , - - 2014
Most sewers in developing countries are combined sewers which receive stormwater and effluent from septic tanks or cesspools of households and buildings. Although the wastewater strength in these sewers is usually lower than those in developed countries, due to improper construction and maintenance, the hydraulic retention time (HRT) could be ...
Malanson George P GP Department of Geographical & Sustainability Sciences, University of Iowa, Iowa City, IA, - - 2014
The effects of extended climatic variability on agricultural land use were explored for the type of system found in villages of northeastern Thailand. An agent based model developed for the Nang Rong district was used to simulate land allotted to jasmine rice, heavy rice, cassava, and sugar cane. The land ...
Chan Matthew H MH School of Mathematics and Statistics, University of Sydney, Sydney, NSW, 2006, Australia, - - 2014
In this study, we use a spatially implicit, stage-structured model to evaluate marine reserve effectiveness for a fish population exhibiting depensatory (strong Allee) effects in its dynamics. We examine the stability and sensitivity of the equilibria of the modelled system with regards to key system parameters and find that for ...
Satish K V KV Forestry and Ecology Group, National Remote Sensing Centre, ISRO, Balanagar, Hyderabad, 500 037, - - 2014
Deforestation in the biosphere reserves, which are key Protected Areas has negative impacts on biodiversity, climate, carbon fluxes and livelihoods. Comprehensive study of deforestation in biosphere reserves is required to assess the impact of the management effectiveness. This article assesses the changes in forest cover in various zones and protected ...
Zimmermann B B Faculty of Applied Ecology and Agricultural Sciences, Hedmark University College, Campus Evenstad, - - 2014
The functional response of a predator describes the change in per capita kill rate to changes in prey density. This response can be influenced by predator densities, giving a predator-dependent functional response. In social carnivores which defend a territory, kill rates also depend on the individual energetic requirements of group ...
Benjankar Rohan R Center for Ecohydraulics Research, University of Idaho, 322 E. Front Street, Boise, ID 83702, USA. Electronic address: - - 2014
Dam operations have altered flood and flow patterns and prevented successful cottonwood seedling recruitment along many rivers. To guide reservoir flow releases to meet cottonwood recruitment needs, we developed a spatially-distributed, GIS-based model that analyzes the hydrophysical requirements for cottonwood recruitment. These requirements are indicated by five physical parameters: (1) ...
Noel Adam - - 2014
In this paper, we perform receiver design for a diffusive molecular communication environment. Our model includes flow in any direction, sources of information molecules in addition to the transmitter, and enzymes in the propagation environment to mitigate intersymbol interference. We characterize the mutual information between receiver observations to show how ...
Grimsrud K N KN Campus Veterinary Services, School of Veterinary Medicine, University of California, Davis, CA, - - 2014
The present study characterizes the pharmacokinetic (PK) and pharmacodynamic (PD) relationships of the α2 -adrenergic receptor agonists detomidine (DET), medetomidine (MED) and dexmedetomidine (DEX) in parallel groups of horses from in vivo data after single bolus doses. Head height (HH), heart rate (HR), and blood glucose concentrations were measured over ...
Rikhtehgaran Reyhaneh R Department of Mathematical Sciences, Isfahan University of Technology, Isfahan, - - 2014
In this paper, we investigate the impact of time-invariant covariates when fitting transition mixed models. This is carried out by emphasizing on the role of baseline responses on the estimation process. Transition models are allowed for two cases of exogenous and endogenous baseline responses. We illustrate these concepts in the ...
Soo Jhy-Charm JC 1.Exposure Assessment Branch (EAB), Health Effects Laboratory Division (HELD), National Institute for Occupational Safety and Health (NIOSH), 1095 Willowdale Road, Morgantown, WV 26505, - - 2014
Lee et al. (Evaluation of pump pulsation in respirable size-selective sampling: part I. Pulsation measurements. Ann Occup Hyg 2014a;58:60-73) introduced an approach to measure pump pulsation (PP) using a real-world sampling train, while the European Standards (EN) (EN 1232-1997 and EN 12919-1999) suggest measuring PP using a resistor in place ...
Mbaye S S Irstea, UR TSCF, Domaine des Palaquins, F-03150 Montoldre, - - 2014
The flow curve of anaerobically digested wastes from different origins was determined through rheological measurements. Regardless of their origin, samples can be divided into two families: simple non-Newtonian liquids well modelled by basic power law below 10%DC and viscoelastic liquids with a yield stress, well modelled by a Herschel-Bulkley model ...
Gederi Elnaz E Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford OX1 3PJ, UK. Electronic address: - - 2014
Non-invasive assessment of ventilatory control stability or loop gain (which is a key contributor in a number of sleep-related breathing disorders) has proven to be cumbersome. We present a novel multivariate autoregressive model that we hypothesize will enable us to make time-varying measurements of loop gain using nothing more than ...
Pazmino Eddy - - 2014
Colloid release from surfaces in response to ionic strength and flow perturbations has been mechanistically simulated. However, these models do not address the mechanism by which colloid attachment occurs, at least in the presence of bulk colloid-collector repulsion (unfavorable conditions), which is a prevalent environmental condition. We test whether a ...
Nasser Azmi F AF Reckitt Benckiser Pharmaceuticals Inc., 10710 Midlothian Turnpike, Suite 430, Richmond, VA, 23235, USA, - - 2014
This study implemented pharmacokinetic/pharmacodynamic modelling to support the clinical development of RBP-6000, a new, long-acting, sustained-release formulation of buprenorphine for the treatment of opioid dependence. Such a formulation could offer advantages over existing buprenorphine pharmacotherapy by improving patient compliance and reducing the diversion of the product. A population pharmacokinetic model ...
Sepúlveda Nicasio N Watermark Numerical Computing, Brisbane, - - 2014
A groundwater flow model for east-central Florida has been developed to help water-resource managers assess the impact of increased groundwater withdrawals from the Floridan aquifer system on heads and spring flows originating from the Upper Floridan Aquifer. The model provides a probabilistic description of predictions of interest to water-resource managers, ...
Jeffrey Starn J J U.S. Geological Survey, Bldg. 15 McKelvey Building, 345 Middlefield Rd. 496, Menlo Park, CA 94025; - - 2014
Models need not be complex to be useful. An existing groundwater-flow model of Salt Lake Valley, Utah, was adapted for use with convolution-based advective particle tracking to explain broad spatial trends in dissolved solids. This model supports the hypothesis that water produced from wells is increasingly younger with higher proportions ...
Farid Asam A Institute of Geology, University of Punjab, P.O. Box 54590, Lahore, Pakistan, - - 2014
Geostatistical variogram and inversion techniques combined with modern visualization tools have made it possible to re-model one-dimensional electrical resistivity data into two-dimensional (2D) models of the near subsurface. The resultant models are capable of extending the original interpretation of the data to depict alluvium layers as individual lithological units within ...
Dimitriou Christopher J CJ Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. - - 2014
Guided by a series of discriminating rheometric tests, we develop a new constitutive model that can quantitatively predict the key rheological features of waxy crude oils. We first develop a series of model crude oils, which are characterized by a complex thixotropic and yielding behavior that strongly depends on the ...
Ramirez Tzutzuy T BASF SE Experimental Toxicology and Ecology, Carl-Bosch Str.38, 67056 Ludwigshafen am Rhein, - - 2014
Endocrine disrupting compounds (EDCs) of natural or synthetic origin can interfere with the balance of the hormonal system, either by altering hormone production, secretion, transport, or their binding and consequently lead to an adverse outcome in intact animals. An important aspect is the prediction of effects of combined exposure to ...
VanderWeele Tyler J TJ From the Departments of Epidemiology and Biostatistics, Harvard School of Public Health, Boston, - - 2014
The overall effect of an exposure on an outcome, in the presence of a mediator with which the exposure may interact, can be decomposed into 4 components: (1) the effect of the exposure in the absence of the mediator, (2) the interactive effect when the mediator is left to what ...
Jones Gareth G Arena Pharmaceuticals, 6154 Nancy Ridge Drive, San Diego, CA, 92121, USA, - - 2014
The half maximal response of any compound in a biological system is a fundamental measure of the compound's potency whether the activity of the compound is beneficial or detrimental. As such, the estimation of this response as an Ec50 or an Ic50 results in a value that has fundamental significance ...
Yang Xuguang X School of Mathematics and Statistics, Huazhong University of Science and Technology, Wuhan 430074, - - 2014
In this paper, two modified lattice Boltzmann Bhatnagar-Gross-Krook (LBGK) models for incompressible Navier-Stokes equations and convection-diffusion equations are proposed via the addition of correction terms in the evolution equations. Utilizing this modification, the value of the dimensionless relaxation time in the LBGK model can be kept in a proper range, ...
Marrotte R R RR Redpath Museum, McGill University, 859 Sherbrooke Street W., Montréal, Québec, H3A 0C4, Canada; Department of Biology, McGill University, 1205 Ave Docteur Penfield, Montréal, Québec, H3A 1B1, - - 2014
We evaluated the effect of habitat and landscape characteristics on the population genetic structure of the white-footed mouse. We develop a new approach that uses numerical optimization to define a model that combines site differences and landscape resistance to explain the genetic differentiation between mouse populations inhabiting forest patches in ...
Seamone Scott S Department of Biology, Dalhousie University, 1355 Oxford Street, Halifax, NS B3H 4R2, Canada. Electronic address: - - 2014
Escape responses are often critical for surviving predator-prey interactions. Nevertheless, little is known about how predator size, speed and approach orientation impact escape performance, especially in larger prey that are primarily viewed as predators. We used realistic shark models to examine how altering predatory behavior and morphology (size, speed and ...
Hu Ning N College of Agriculture, Nanjing Agricultural University, 1 Weigang, Nanjing, 210095, Jiangsu, People's Republic of - - 2014
Because of the rapid development of transgenic maize, the potential effect of transgene flow on seed purity has become a major concern in public and scientific communities. Setting a proper isolation distance in field experiments and seed production is a possible solution to meet seed-quality standards and ensure adventitious contamination ...
Cousins Will W Department of Mechanical Engineering, Massachusetts Institute of Technology, Boston, MA, 02139, - - 2014
We discuss the implementation and calibration of a new generalized structured tree boundary condition for hemodynamics. The main idea is to approximate the impedance corresponding to the vessels downstream from a specific outlet. Unlike previous impedance conditions, the one considered here is applicable to general transient flows as opposed to ...
Jetten Marlon J A MJ Department of Toxicogenomics, Maastricht University, Maastricht, The Netherlands. Electronic address: - - 2014
Large differences in toxicity responses occur within the human population. In this study we evaluate whether interindividual variation in baseline enzyme activity (EA)/gene expression (GE) levels in liver predispose for the variation in toxicity responses by assessing dose-response relationships for several prototypical hepatotoxicants. Baseline levels of cytochrome-P450 (CYP) GE/EA were ...
Ramin Elham E Department of Environmental Engineering (DTU Environment), Technical University of Denmark, Miljøvej, Building 113, DK-2800, Kgs. Lyngby, Denmark. Electronic address: - - 2014
Current research focuses on predicting and mitigating the impacts of high hydraulic loadings on centralized wastewater treatment plants (WWTPs) under wet-weather conditions. The maximum permissible inflow to WWTPs depends not only on the settleability of activated sludge in secondary settling tanks (SSTs) but also on the hydraulic behaviour of SSTs. ...
White J K JK Faculty of Engineering and the Environment, University of Southampton, Highfield, Southampton SO17 1BJ, UK. Electronic address: - - 2014
This paper describes the finite difference algorithm that has been developed for the flow sub-model of the University of Southampton landfill degradation and transport model LDAT. The liquid and gas phase flow components are first decoupled from the solid phase of the full multi-phase, multi-component landfill process constitutive equations and ...
Parazoo Nicholas C NC Jet Propulsion Laboratory, California Institute of Technology, Pasadena, CA, 91109, USA; Joint Institute for Regional Earth System Science and Engineering, University of California, Los Angeles, CA, 90095, - - 2014
Determining the spatial and temporal distribution of terrestrial gross primary production (GPP) is a critical step in closing the Earth's carbon budget. Dynamical global vegetation models (DGVMs) provide mechanistic insight into GPP variability but diverge in predicting the response to climate in poorly investigated regions. Recent advances in the remote ...
Dwyer Mary Ann - - 2014
Human butyrylcholinesterase (hBChE) is currently being developed as a detoxication enzyme for stoichiometric binding and/or catalytic hydrolysis of organophosphates. Herein, we describe the use of a molecular evolution method to develop novel hBChE variants with increased resistance to stereochemically defined nerve agent model compounds of soman, sarin, and cyclosarin. Novel ...
Boström Emma E AstraZeneca R&D, Södertälje, - - 2014
Fostamatinib is an oral spleen tyrosine kinase (SYK) inhibitor which has been evaluated as a potential treatment for rheumatoid arthritis (RA). Treatment with fostamatinib has been associated with an increase in blood pressure (BP). In this work, we present a pooled analysis of the pharmacokinetic-pharmacodynamic (PKPD) relationship for BP, based ...
Jiao Jianying J Department of Geology and Geophysics, University of Wyoming, Laramie, WY - - 2014
A physically based inverse method is developed using hybrid formulation and coordinate transform to simultaneously estimate hydraulic conductivity tensors, steady-state flow field, and boundary conditions for a confined aquifer under ambient flow or pumping condition. Unlike existing indirect inversion techniques, the physically based method does not require forward simulations to ...
Jin Yu Y Centre for Mathematical Biology, Department of Mathematical and Statistical Sciences, University of Alberta, Edmonton, AB , T6G 2G1, Canada, - - 2014
A key problem in environmental flow assessment is the explicit linking of the flow regime with ecological dynamics. We present a hybrid modeling approach to couple hydrodynamic and biological processes, focusing on the combined impact of spatial heterogeneity and temporal variability on population dynamics. Studying periodically alternating pool-riffle rivers that ...
Clark James S - - 2014
The recent global increase in forest mortality episodes could not have been predicted from current vegetation models that are calibrated to regional climate data. Physiological studies show that mortality results from interactions between climate and competition at the individual scale. Models of forest response to climate do not include interactions ...
Ramachandran Gurumurthy G Department of Environmental Health Sciences, University of Minnesota, Minneapolis, MN, - - 2014
After the Deepwater Horizon, response vessels were brought near the wellhead area to stop the leak, collect oil and drill the relief wells. The objective of this paper is to characterise inhalation exposure on these vessels for various exposure groups (EGs) to total hydrocarbons (THCs). Approximately 100 EGs based on ...
Vermeulen Roel R Iras Utrecht University, Utrecht, The - - 2014
Derivation of the exposure-response curve at low (occupational) exposures is often troubled by the fact that within epidemiological investigations power to discern the exposure-response curve (ERC) at low exposure levels is often limited. Conversely, we often observe non-linear exposure-response curves at the higher end of the exposure range which amongst ...
Hu Chuanpu C Model Based Drug Development, Janssen Research & Development, LLC, PO Box 776, 1400 McKean Road, Spring House, PA, 19477, USA, - - 2014
Ustekinumab, a human immunoglobulin G1 kappa (IgG1κ) monoclonal antibody that binds with high affinity to human interleukin (IL)-12 and IL-23, has been approved to treat patients with psoriasis. Guselkumab is a related human IgG1 monoclonal antibody in clinical development which specifically blocks IL-23. The objective of this study was to ...
Ramakrishnan Sridhar S DoD Biotechnology High Performance Computing Software Applications Institute, Telemedicine and Advanced Technology Research Center, U.S. Army Medical Research and Materiel Command, 504 Scott Street, Fort Detrick, MD 21702, - - 2014
Caffeine is the most widely consumed stimulant to counter sleep-loss effects. While the pharmacokinetics of caffeine in the body is well-understood, its alertness-restoring effects are still not well characterized. In fact, mathematical models capable of predicting the effects of varying doses of caffeine on objective measures of vigilance are not ...
Crompton L A LA Animal Science Research Group, School of Agriculture, Policy and Development, University of Reading, Whiteknights, Reading RG6 6AR, UK. Electronic address: - - 2014
An isotope dilution model for partitioning phenylalanine and tyrosine uptake by the mammary gland of the lactating dairy cow is constructed and solved in the steady state. The model contains four intracellular and four extracellular pools and conservation of mass principles are applied to generate the fundamental equations describing the ...
Andres-Mach Marta M Isobolographic Analysis Laboratory, Institute of Agricultural Medicine, Lublin, - - 2014
Background: The aim of this study was to characterize the anticonvulsant effect of 1-methyl-1,2,3,4-tetrahydroisoquinoline (1-MeTHIQ) in combination with clobazam (CLB) in the mouse maximal electroshock-induced seizure (MES) model. Methods: The anticonvulsant interaction profile between 1-MeTHIQ and CLB in the mouse MES model was determined using an isobolographic analysis for parallel ...
Salmi L Rachid LR Univ. Bordeaux, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, , Bordeaux, - - 2014
In 1994, Robertson and Drummer formalised the responsibility analysis as an alternative to case-control studies in the study of road traffic crashes. Our objective was to assess whether published responsibility studies respected standards defining adequate case-control studies. Using Web of Science, Scopus and Google Scholar, we identified responsibility studies indexed ...
Yao Franklin F Department of Urology, Weill Medical College of Cornell University, New York-Presbyterian Hospital, New York, New - - 2014
The goal of this study is to develop an image-based model of urethral distention and resistance in women with and without SUI. A biomechanical vector force model was created to simulate the mechanical deformation of pelvic floor structures during cough and Valsalva in order to measure urethral distension and predict ...
Pal Abhro - - 2014
In the present study, we performed large eddy simulation (LES) of axisymmetric, and 75% stenosed, eccentric arterial models with steady inflow conditions at a Reynolds number of 1000. The results obtained are compared with the direct numerical simulation (DNS) data [1]. An inhouse code (WenoHemoTM) employing high-order numerical methods for ...
Tabandeh Hosseinali H Department of Pharmaceutics, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Vali-e-asr Avenue, Niayesh junction, PO Box 14155-6153, Tehran, - - 2014
This study was performed to achieve sustained-release Ibuprofen matrix tablets with a zero-order release kinetic while most of the previous formulations have shown Higuchi release kinetic. Considering the results from previous studies, ethyl cellulose, Carbopol 934P, Carbopol 974P, and Pemulen TR-1 were used at different amounts for preparation of the ...
Hoffman Megan L ML Department of - - 2014
Is self-reflection necessary for metacognition to occur? Like Kornell (2014, pp. 143-149), we struggle with this question. If humans metacognition is not always self-reflective, why should we expect animals to be so? We suggest that one way to pursue metacognition in animals is to examine its ecological and evolutionary relevance. ...
Medina L Carolina - - 2014
Several technologies have been proposed to characterize the nutrient release patterns of enhanced-efficiency fertilizers (EEFs) during the last few decades. These technologies have been developed mainly by manufacturers and are product-specific based on the regulation and analysis of each EEF product. Despite previous efforts to characterize nutrient release of slow-release ...
Megaritis Athanasios G AG Department of Chemical Engineering, University of Patras, 26500 Patras, Greece; Institute of Chemical Engineering Sciences, Foundation for Research and Technology Hellas (ICEHT/FORTH), 26504 Patras, - - 2014
The global-regional climate-air pollution modeling system (GRE-CAPS) was applied over the eastern United States to study the impact of climate change on the concentration and deposition of atmospheric mercury. Summer and winter periods (300days for each) were simulated, and the present-day model predictions (2000s) were compared to the future ones ...
Bolt Daniel M - - 2014
Response styles are frequently of concern when rating scales are used in psychological survey instruments. While latent trait models provide an attractive way of controlling for response style effects (Morren, Gelissen, & Vermunt, 2011), the analyses are generally limited to accommodating only a small number of response style types. The ...
Coomes David D Forest Ecology and Conservation Group, Department of Plant Sciences, University of Cambridge, Downing Street, Cambridge, CB2 - - 2014
Established forests currently function as a major carbon sink, sequestering as woody biomass about 26% of global fossil fuel emissions. Whether forests continue to act as a global sink will depend on many factors, including the response of aboveground wood production (AWP; MgC ha(-1) yr(-1) ) to climate change. Here ...
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