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Blanes-Vidal Victoria V Department of Chemical Engineering, Biotechnology and Environmental Technology, Faculty of Engineering, University of Southern Denmark, Odense, - - 2014
Previous studies have reported increased occurrence of respiratory and sensory irritation symptoms among residents living close to biodegradable waste sites. However, few studies have been able to quantify direct and annoyance-mediated effects based on individual-specific assessments of chemical exposures. We examined associations between residential exposures to a proxy gas (ammonia, ...
Spinczyk Dominik D Faculty of Biomedical Engineering, Silesian University of Technology , Gliwice , Poland , - - 2014
Abstract Non-invasive surface registration methods have been developed to register and track breathing motions in a patient's abdomen and thorax. We evaluated several different registration methods, including marker tracking using a stereo camera, chessboard image projection, and abdominal point clouds. Our point cloud approach was based on a time-of-flight (ToF) ...
Mathews Stephanie - - 2014
Over the last four decades, chronic ethanol feeding studies in rodents using either ad libitum feeding or intragastric infusion models have significantly enhanced our understanding of the pathogenesis of alcoholic liver disease (ALD). Recently, we developed a chronic plus binge alcohol feeding model in mice that is similar to the ...
Juen Joshua J 1 Department of Medical Information Science, Department of Computer Science, Institute for Genomic Biology, University of Illinois at Urbana-Champaign , Urbana, - - 2014
Abstract We have developed GaitTrack, a phone application to detect health status while the smartphone is carried normally. GaitTrack software monitors walking patterns, using only accelerometers embedded in phones to record spatiotemporal motion, without the need for sensors external to the phone. Our software transforms smartphones into health monitors, using ...
Smirnova O A OA *Federal State Unitary Enterprise Research and Technical Center of Radiation-Chemical Safety and Hygiene, 40 Shchukinskaya St., Moscow, 123182, Russian Federation; †Urals Research Center for Radiation Medicine (URCRM), 68-a Vorovsky St., Chelyabinsk, 454076, Russian - - 2014
A profound approach to the analysis of clinical data on the dynamics of major hematopoietic lineages (granulocytopoietic, thrombocytopoietic, and erythrocytopoietic systems) in chronically irradiated humans is proposed. It is based on recently developed mathematical models of these systems in humans, which enable one to study and interpret clinical hematological data. ...
Janssen Larry L a Larry Janssen Consulting, LLC , Stillwater , - - 2014
Workplace protection factors (WPFs) are intended to measure the ability of a respiratory protective device (RPD) to reduce contaminant exposure when used in the context of an effective respiratory protection program. In 1992, members of the American Industrial Hygiene Association Respiratory Protection Committee (RPC) published a review of important issues ...
Kasza Jessica J Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia; Victorian Centre for Biostatistics (ViCBiostat), Melbourne, Victoria, - - 2014
This article provides a review of techniques for the analysis of survival data arising from respiratory health studies. Popular techniques such as the Kaplan-Meier survival plot and the Cox proportional hazards model are presented and illustrated using data from a lung cancer study. Advanced issues are also discussed, including parametric ...
Smirnova Olga A OA Federal State Unitary Enterprise Research and Technical Center of Radiation-Chemical Safety and Hygiene, 40 Shchukinskaya st., 123182 , Moscow, Russian - - 2014
A biologically motivated dynamical model of the lymphocytopoietic system in irradiated humans is applied here to analyze the data obtained under hematological examinations of residents of Techa riverside villages. Those people were exposed to chronic irradiation with varying dose rates, due to the radioactive contamination of the river basin by ...
Valdés M M Uranium Medical Research Center, Shawville, Quebec, Canada J0X - - 2014
A procedure is presented to estimate the respiratory tract burden from a prolonged inhalation exposure to particulate matter of depleted uranium, in cases where the rate of deposition is an unknown function. The precise range of possible values is identified. The calculations are based on the amount of depleted uranium ...
Tarassenko L L Department of Engineering Science, Institute of Biomedical Engineering, University of Oxford, - - 2014
Remote sensing of the reflectance photoplethysmogram using a video camera typically positioned 1 m away from the patient's face is a promising method for monitoring the vital signs of patients without attaching any electrodes or sensors to them. Most of the papers in the literature on non-contact vital sign monitoring report ...
Smirnova Olga A OA a  Federal State Unitary Enterprise Research and Technical Center of Radiation-Chemical Safety and Hygiene, Moscow, - - 2014
In this work, a recently developed mathematical model of the lymphocytopoietic system in acutely irradiated humans was extended to predict the dynamics of this system both in nonirradiated and acutely/chronically irradiated humans. The mathematical implementation of this model is a system of nonlinear ordinary differential equations, whose variables and parameters ...
Wang Allen Y - - 2014
Tympanic membrane perforations (TMP) are relatively common but are typically not treated in their acute stage, as most will heal spontaneously in 7-10 days. Those cases which fail to heal within 3 months are called chronic TMP which attract surgical intervention (e.g. myringoplasty), typically with a temporalis fascia autograft. New ...
Lemaire Cyril C TIMR, Université de Technologie de Compiègne, Compiègne, France, - - 2014
Monitoring of the biological degradation of a substrate by microorganisms is a key issue, especially in the soil bioremediation area. Respiration measurement is the easiest way to obtain online information on the biological activity. Nevertheless, it is indirectly related to substrate consumption and microbial growth. To be able to link ...
De Keyser K K KU Leuven Department of Biosystems, Livestock Genetics, Leuven, - - 2014
Genetic parameters for chronic progressive lymphedema (CPL)-associated traits in Belgian Draught Horses were estimated, using a multitrait animal model. Clinical scores of CPL in the four limbs/horse (CPLclin ), skinfold thickness and hair samples (hair diameter) were studied. Due to CPLclin uncertainty in younger horses (progressive CPL character), a restricted ...
Li Bassi Gianluigi G From the Department of Pulmonary and Critical Care Medicine, Thorax Institute, Hospital Clínic, Barcelona, Spain (G.L.B., M.R., J.-D.M., L.S., O.T.R., V.G., N.L., M.R., M.E., L.F.-B., M.F., A.T.); Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain (G.L.B., M.R., J.-D.M., I.R., L.M., L.F.-B., M.F., J.V., A.T.); Centro de Investigación Biomedica En Red- Enfermedades Respiratorias (CIBERES), Mallorca, Spain (G.L.B., M.R., O.T.R., V.G., M.R., M.E., L.F.-B., M.F., A.T.); Cardiology Department, Thorax Institute, Hospital Clínic, Barcelona, Spain (M.R.); Department of Clinical Microbiology, School of Medicine, and Barcelona Centre for International Health Research, (CRESIB, Hospital Clínic-Universitat de Barcelona), Barcelona, Spain (I.R., L.M., J.V.); Pathology Department, Hospital Clínic, Barcelona, Spain (M.C., J.R.); and University of Barcelona, Barcelona, Spain (J.V., J.R., - - 2014
Animal models of ventilator-associated pneumonia (VAP) in primates, sheep, and pigs differ in the underlying pulmonary injury, etiology, bacterial inoculation methods, and time to onset. The most common ovine and porcine models do not reproduce the primary pathogenic mechanism of the disease, through the aspiration of oropharyngeal pathogens, or the ...
Fisher Edward M EM National Personal Protective Technology Laboratory, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Pittsburgh, PA, - - 2014
Facemasks are part of the hierarchy of interventions used to reduce the transmission of respiratory pathogens by providing a barrier. Two types of facemasks used by healthcare workers are N95 filtering facepiece respirators (FFRs) and surgical masks (SMs). These can become contaminated with respiratory pathogens during use, thus serving as ...
van Drunen Erwin J - - 2014
Patients with acute respiratory distress syndrome (ARDS) risk lung collapse, severely altering the breath-to-breath respiratory mechanics. Model-based estimation of respiratory mechanics characterising patient-specific condition and response to treatment may be used to guide mechanical ventilation (MV). This study presents a model-based approach to monitor time-varying patient-ventilator interaction to guide positive ...
Smirnova Olga Andreevna OA Federal State Unitary Enterprise Research and Technical Center of Radiation-Chemical Safety and Hygiene, 40 Shchukinskaya St, Moscow 123182, Russian - - 2014
Biologically motivated mathematical models, which describe the dynamics of the thrombocytopoietic, granulocytopoietic and erythropoietic systems in irradiated humans, are developed and thoroughly investigated [ 1- 3]. These models are implemented as the systems of non-linear ordinary differential equations, whose variables and constant parameters have clear biological meaning. The modeling studies ...
Lee Rebecca R 1Medical University of South - - 2014
The Interstitial Lung Diseases (ILD) include a large number of chronic, progressive, irreversible respiratory disorders involving pulmonary fibrosis, the most common of which are idiopathic pulmonary fibrosis (IPF) and scleroderma lung disease (SSc ILD). Because bleomycin causes lung fibrosis when used in cancer chemotherapy, it is used to model human ...
Ripka Wagner L - - 2014
There are several ways to measure the respiratory system, among them inductance plethysmography and three-dimensional kinematic analysis, methods of high cost and difficult transportability. The objective of this study was to correlate respiratory volumes obtained by spirometry standard equipment with a biomechanical model photogrammetric analysis of adolescents. We evaluated 50 ...
Mehta Nilesh M NM Boston Children's Hospital, Boston, MA, United States; Harvard Medical School, Boston, MA, United States. Electronic address: - - 2014
Accurate assessment of resting energy expenditure (REE) and metabolic state is essential to optimize nutrient intake in critically ill patients. We aimed to examine the accuracy of a simplified equation for predicting REE using carbon dioxide elimination (VCO2) values. We conducted a two-center study of metabolic data from mechanically ventilated ...
Gaughan Denise M DM a Department of Preventive Medicine and the Institute for Translational Epidemiology, Icahn School of Medicine at Mount Sinai , New York , New - - 2014
ABSTRACT Respiratory problems are common among wildland firefighters. However, there are few studies directly linking occupational exposures to respiratory effects in this population. Our objective was to characterize wildland firefighting occupational exposures and assess their associations with cross-shift changes in lung function. We studied 17 members of the Alpine Interagency ...
Högman M M Centre for Research and Development, Uppsala University/County Council of Gävleborg, SE 801 88 Gävle, Sweden. Department of Medical Sciences, Lung Medicine and Allergology, Uppsala University, - - 2014
Expired nitric oxide (NO) is used as a biomarker in different respiratory diseases. The recommended flow rate of 50 mL s(-1) (FENO0.05) does not reveal from where in the lung NO production originated. Theoretical models of NO transfer from the respiratory system, linear or nonlinear approaches, have therefore been developed and applied. These ...
Buehler S S Division for Experimental Anesthesiology, Department of Anesthesiology, University Medical Center Freiburg, Hugstetter Str. 55, 79106, Freiburg, Germany, - - 2014
In mechanical ventilation, a careful setting of the ventilation parameters in accordance with the current individual state of the lung is crucial to minimize ventilator induced lung injury. Positive end-expiratory pressure (PEEP) has to be set to prevent collapse of the alveoli, however at the same time overdistension should be ...
Mu Yunsong Y State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing 100012, - - 2014
Criteria continuous concentrations (CCCs) are useful for describing chronic exposure to pollutants and setting water quality standards to protect aquatic life. However, because of financial, practical, or ethical restrictions on toxicity testing, few data are available to derive CCCs. In this study, CCCs for 34 metals or metalloids were derived ...
Dimakopoulou Konstantina K University of Athens, Medical School, Department of Hygiene, Epidemiology and Medical Statistics, Athens, - - 2014
Rationale: Prospective cohort studies have shown that chronic exposure to particulate matter and traffic related air pollution is associated with reduced survival. However, the effects on non-malignant respiratory mortality are less studied and those reported are less consistent. Objectives: We have investigated the relationship of long-term exposure to air pollution ...
Lam Yan Y YY Pennington Biomedical Research Center, Baton Rouge, LA (YYL, LMR, GAB, FLG, DJ, and ER), and Florida Hospital and Sanford-Burnham Translational Research Institute, Orlando, FL - - 2014
Achieving energy balance is critical for the interpretation of results obtained in respiratory chambers. However, 24-h energy expenditure (24EE) predictions based on estimated resting metabolic rate and physical activity level are often inaccurate and imprecise. We aimed to develop and validate equations to better achieve energy balance in a respiratory ...
Del Rosso James Q JQ Clinical Professor (Dermatology), Touro University College of Osteopathic Medicine, Henderson, Nevada; Private Practice of Dermatology and Cutaneous Surgery, Las Vegas Skin and Cancer Clinics/West Dermatology Group, Las Vegas and Henderson, - - 2014
A commonly encountered skin disorder in outpatient dermatology practice is hand dermatitis. In a considerable subset of patients, hand dermatitis can be a major source of prolonged distress when a pattern of chronicity develops due to repeated exposure to a variety of potential etiological factors. Most of the etiological factors ...
Austin T J TJ a Shell Risk Science Team, Shell Health , Manchester , - - 2014
To comply with the REACH (Registration, Evaluation, Authorisation and restriction of Chemicals) regulations, the generation of chronic fish toxicity data is required for chemicals produced or imported within or into the EU in quantities greater than 100 tonnes per year. This comes at a great cost to industry and consumers ...
Suh Sangwon - - 2014
We examined the potential life-cycle environmental impact reduction of three green building code and certification (GBCC) systems: LEED®, ASHRAE 189.1, and IgCC. A recently completed whole-building life cycle assessment (LCA) database of NIST was applied to a prototype building model specification by NREL. TRACI 2.0 of EPA was used for ...
Leggett R - - 2014
ABSTRACT Purpose: This paper reviews data related to the behavior of the lanthanoid elements (lanthanum through lutetium, atomic numbers 57-71) in the human body and proposes biokinetic models for internally deposited radio-lanthanoids in workers. Materials and Methods: Published data on the following topics are reviewed and analyzed: Physico-chemical properties of ...
Ma Baoshun B 1The University of - - 2014
The forces of mechanical interdependence between the airways and the parenchyma in the lung are powerful modulators of airways responsiveness. Little is known, however, about the extent to which adjacent airways affect each other's ability to narrow due to distortional forces generated within the intervening parenchyma. We developed a 2-dimensional ...
Messinger H H Bioresco Food Scientific and Regulatory Services, Jülicherstr. 369, 52070 Aachen, Germany. Electronic address: - - 2014
Under the current European legislation for the Registration, Evaluation, Authorisation and restriction of Chemicals (REACH) a Derived No Effect Level (DNEL) has to be delineated for acute and chronic inhalation effects. The majority of available experimental studies are performed by the oral route of exposure. Route to route extrapolation poses ...
Pinho Cátia C School of Health Sciences, University of Aveiro (ESSUA), Agras do Crasto - Campus Universitário de Santiago - Edifício 30, 3810-193 Aveiro, Portugal; Institute of Electronics and Telematics Engineering of Aveiro (IEETA), University of Aveiro, Campus Universitário de Santiago, 3810-193 Aveiro, Portugal. Electronic address: - - 2014
The development of effective graphical user interfaces (GUIs) has been in an emergent demand in healthcare technologies, for assessing, managing and storing patients' clinical data. Nevertheless, specifically for respiratory care there is a lack of tools to produce a multimedia database, where the main respiratory clinical data can be available ...
Garde Ainara A Electrical and Computer Engineering in Medicine Group, The University of British Columbia and BC Childrens Hospital, Vancouver, British Columbia, Canada ; Anesthesiology, Pharmacology and Therapeutics, The University of British Columbia and BC Childrens Hospital, Vancouver, British Columbia, - - 2014
The photoplethysmogram (PPG) obtained from pulse oximetry measures local variations of blood volume in tissues, reflecting the peripheral pulse modulated by heart activity, respiration and other physiological effects. We propose an algorithm based on the correntropy spectral density (CSD) as a novel way to estimate respiratory rate (RR) and heart ...
Yu Yanyan Y Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China ; Key Laboratory of Environment and Health in Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, - - 2014
Millions of people rely on N95 filtering facepiece respirators to reduce the risk of airborne particles and prevent them from respiratory infections. However, there are no respirator fit testing and training regulations in China. Meanwhile, no study has been conducted to investigate the fit of various respirators. The objective of ...
van den Brand J M A JM Department of Viroscience, Erasmus Medical Center, Dr. Molewaterplein 50, 3015 GE Rotterdam, The - - 2014
Respiratory viruses that emerge in the human population may cause high morbidity and mortality, as well as concern about pandemic spread. Examples are severe acute respiratory syndrome coronavirus (SARS-CoV) and novel variants of influenza A virus, such as H5N1 and pandemic H1N1. Different animal models are used to develop therapeutic ...
Mekenyan Ovanes Garo - - 2014
Chemical respiratory sensitization is an important occupational health problem which may lead to severely incapacitated human health yet there are currently no validated or widely accepted models for identifying and characterizing the potential of a chemical to induce respiratory sensitization. This is in part due to on-going uncertainty about the ...
Patlar Akbulut Fatma - - 2014
Choosing the correct ventilator settings for the treatment of patients with respiratory tract disease is quite an important issue. Since the task of specifying the parameters of ventilation equipment is entirely carried out by a physician, physician's knowledge and experience in the selection of these settings has a direct effect ...
Ng Stephanie S 1Baylor College of Medicine, Houston, TX, - - 2014
Background:We examined emergency room (ER) utilization by persons with dementia (PWDs) using caregiver and patient characteristics as predictors.Methods:A secondary analysis of 296 veteran-caregiver dyads. Caregivers recorded PWD baseline characteristics and noted ER visits over the next year. Two sets of regression models analyzed categorical ER use and repeat ER use.Results:In ...
You Siming S School of Mechanical and Aerospace Engineering, Nanyang Technological University, 50 Nanyang Avenue, 639798, Singapore, - - 2014
Ventilation duct serves as a potential target for bioterrorist attack. Understanding the dynamics of aerosolized harmful agents in the ventilation ducts provides the fundamentals for effective control and management, e.g., risk assessment. In this work, new models for predicting the concentration dynamics in the ventilation duct after a particle resuspension ...
Aris-Brosou Stéphane S Department of Biology, Center for Advanced Research in Environmental Genomics, University of Ottawa Ottawa, ON, Canada ; Department of Mathematics and Statistics, University of Ottawa Ottawa, ON, - - 2014
Influenza is one of the most severe respiratory infections affecting humans throughout the world, yet the dynamics of its global transmission network are still contentious. Here, I describe a novel combination of phylogenetics, time series, and graph theory to analyze 14.25 years of data stratified in space and in time, focusing ...
Rando Roy J - - 2014
In the aftermath of Hurricane Katrina, which devastated the city of New Orleans in August 2005, restoration workers were at risk for respiratory illness from exposure to airborne particles and microbial agents. In support of an epidemiologic investigation of this risk, an exposure assessment for restoration work activities (demolition, trash ...
Wolfe Rory R School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, - - 2014
Statistics sits right at the heart of scientific endeavour in respiratory medicine and many other disciplines. In this introductory article, some key epidemiological concepts such as representativeness, random sampling, association and causation, and confounding are reviewed. A brief introduction to basic statistics covering topics such as frequentist methods, confidence intervals, ...
Kasza Jessica J Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia; Victorian Centre for Biostatistics (ViCBiostat), Melbourne, Victoria, - - 2014
A review of some regression models commonly used in respiratory health applications is provided in this article. Simple linear regression, multiple linear regression, logistic regression and ordinal logistic regression are considered. The focus of this article is on the interpretation of the regression coefficients of each model, which are illustrated ...
Yao Yu - - 2014
The current rise in popularity of ballisto-cardiography-related research has led to the development of new sensor concepts and recording methods. Measuring the ballistocardiogram using bed mounted pressure sensors opens up new possibilities for home monitoring applications. The signals measured with these sensors contain a mixture of cardiac and respiratory components, ...
Xu Yuan Y Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Florida, Gainesville, FL, - - 2014
Induced mouse models of systemic lupus erythematosus (SLE) have been developed to complement the spontaneous models. This chapter describes the methods used in the pristane-induced model and the chronic graft-versus-host disease (cGVHD) model, both of which have been extensively used. We will also outline the specific mechanisms of systemic autoimmunity ...
Paynter Stuart S School of Population Health, University of Queensland, Brisbane, Queensland, - - 2014
We used a mathematical transmission model to estimate when ecological drivers of respiratory syncytial virus (RSV) transmissibility would need to act in order to produce the observed seasonality of RSV in the Philippines. We estimated that a seasonal peak in transmissibility would need to occur approximately 51 days prior to ...
Healey Gareth D GD College of Medicine, Swansea University, Swansea, United Kingdom ; Allerna Therapeutics Ltd, Swansea University, Swansea, United - - 2014
Developing siRNA therapeutics poses technical challenges including appropriate molecular design and testing in suitable pre-clinical models. We previously detailed sequence-selection and modification strategies for siRNA candidates targeting STAT6. Here, we describe methodology that evaluates the suitability of candidate siRNA for respiratory administration. Chemically-modified siRNA exhibited similar inhibitory activity (IC50) against ...
Chan King Pan KP School of Publish Health, The University of Hong Kong, Hong Kong Special Administrative Region, - - 2014
Poisson model has been widely applied to estimate the disease burden of influenza, but there has been little success in providing reliable estimates for other respiratory viruses. We compared the estimates of excess hospitalization rates derived from the Poisson models with different combinations of inference methods and virus proxies respectively, ...
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