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Yue Xun X State Key Laboratory of Crop Biology, College of Life Sciences, Shandong Agricultural University, Tai'an, Shandong, China; College of Information Sciences and Engineering, Shandong Agricultural University, Taian, Shandong, - - 2014
It is difficult to derive all qualitative proteomic and metabolomic experimental data in male (pollen tube) and female (pistil) reproductive tissues during pollination because of the limited sensitivity of current technology. In this study, genome-scale enzyme correlation network models for plants (Arabidopsis/maize) were constructed by analyzing the enzymes and metabolic ...
Bordoni Bruno B Department of Cardiology, IRCCS S Maria Nascente, Don Carlo Gnocchi Foundation, Milan, Italy ; CRESO Osteopathic Centre for Research and Studies, Milan, - - 2014
Every body structure is wrapped in connective tissue, or fascia, creating a structural continuity that gives form and function to every tissue and organ. Currently, there is still little information on the functions and interactions between the fascial continuum and the body system; unfortunately, in medical literature there are few ...
Kaur Jaspreet J Electrical and Computer Engineering, University of Calgary, Alberta, - - 2014
Fitting parameter sets of non-linear equations in cardiac single cell ionic models to reproduce experimental behavior is a time consuming process. The standard procedure is to adjust maximum channel conductances in ionic models to reproduce action potentials (APs) recorded in isolated cells. However, vastly different sets of parameters can produce ...
Lindsay James - - 2014
Interest in de novo genome assembly has been renewed in the past decade due to rapid advances in high-throughput sequencing (HTS) technologies which generate relatively short reads resulting in highly fragmented assemblies consisting of contigs. Additional long-range linkage information is typically used to orient, order, and link contigs into larger ...
Yüksel Saziye S Department of Mathematics, Faculty of Science, Selçuk University, 42003 Konya, - - 2014
Soft rough sets which are a hybrid model combining rough sets with soft sets are defined by using soft rough approximation operators. Soft rough sets can be seen as a generalized rough set model based on soft sets. The present paper aims to combine the covering soft set with rough ...
Knutsson Hans - - 2014
We present a novel approach to determine a local q-space metric that is optimal from an information theoreticperspective with respect to the expected signal statistics. It should be noted that the approach does not attempt to optimize the quality of a pre-defined mathematical representation, the estimator. In contrast, our suggestion ...
Müller Markus - - 2014
The reconstruction of a 3D volume from a stack of 2D histology slices is still a challenging problem especially if no external references are available. Without a reference, standard registration approaches tend to align structures that should not be perfectly aligned. In this work we introduce a deformable, reference-free reconstruction ...
Roche Alexis - - 2014
We propose a fast algorithm to estimate brain tissue concentrations from conventional T1-weighted images based on a Bayesian maximum a posteriori formulation that extends the "mixel" model developed in the 90's. A key observation is the necessity to incorporate additional prior constraints to the "mixel" model for the estimation of ...
Majumdar Angshul A Indraprastha Institute of Information Technology, Delhi 110020, India. - - 2014
We address the problem of acquiring and transmitting EEG signals in Wireless Body Area Networks (WBAN) in an energy efficient fashion. In WBANs, the energy is consumed by three operations: sensing (sampling), processing and transmission. Previous studies only addressed the problem of reducing the transmission energy. For the first time, ...
Corol Delia I DI Department of Plant Biology and Crop Sciences, Rothamsted Research, West Common, Harpenden, Herts AL5 2JQ, UK. - - 2014
Future improvement of woody biomass crops such as willow and poplar relies on our ability to select for metabolic traits that sequester more atmospheric carbon into biomass, or into useful products to replace petrochemical streams. We describe the development of metabotyping screens for willow, using combined 1D 1H-NMR-MS. A protocol ...
Ares Manuel M - - 2014
High-throughput sequencing (HTS) methods for analyzing RNA populations (RNA-Seq) are gaining rapid application to many experimental situations. The steps in an RNA-Seq experiment require thought and planning, especially because the expense in time and materials is currently higher and the protocols are far less routine than those used for other ...
Sun Guannan G Department of Statistics, University of Wisconsin, Madison, Wisconsin, United States of - - 2014
As next generation sequencing technologies are becoming more economical, large-scale ChIP-seq studies are enabling the investigation of the roles of transcription factor binding and epigenome on phenotypic variation. Studying such variation requires individual level ChIP-seq experiments. Standard designs for ChIP-seq experiments employ a paired control per ChIP-seq sample. Genomic coverage ...
Marwaha Shruti S Department of Molecular and Cellular Physiology, University of Cincinnati, Cincinnati, Ohio, United States of - - 2014
Helicobacter pylori infection of gastric tissue results in an immune response dominated by Th1 cytokines and has also been linked with dysregulation of Sonic Hedgehog (SHH) signaling pathway in gastric tissue. However, since interactions between the cytokines and SHH during H. pylori infection are not well understood, any mechanistic understanding ...
Yu Qihui Q School of Automation Science and Electrical Engineering, Beihang University, Beijing 100191, - - 2014
A new camless compressed air engine is proposed, which can make the compressed air energy reasonably distributed. Through analysis of the camless compressed air engine, a mathematical model of the working processes was set up. Using the software MATLAB/Simulink for simulation, the pressure, temperature, and air mass of the cylinder ...
Steart David C DC Department of Earth Sciences, Invertebrates and Plants Division, Natural History Museum , London , United Kingdom ; Department of Agricultural Sciences, LaTrobe University , Melbourne, Victoria , - - 2014
We document a new species of ovulate cone (Pararaucaria collinsonae) on the basis of silicified fossils from the Late Jurassic Purbeck Limestone Group of southern England (Tithonian Stage: ca. 145 million years). Our description principally relies on the anatomy of the ovuliferous scales, revealed through X-ray synchrotron microtomography (SRXMT) performed ...
Szigeti Balázs B Neuroinformatics Doctoral Training Centre, University of Edinburgh Edinburgh, UK ; OpenWorm Project San Diego, CA, - - 2014
OpenWorm is an international collaboration with the aim of understanding how the behavior of Caenorhabditis elegans (C. elegans) emerges from its underlying physiological processes. The project has developed a modular simulation engine to create computational models of the worm. The modularity of the engine makes it possible to easily modify ...
Jun Young Bae YB Department of Mathematics Education, Gyeongsang National University, Jinju 660-701, Republic of - - 2014
As a link between classical soft sets and hesitant fuzzy sets, the notion of hesitant fuzzy soft sets is introduced and applied to a decision making problem in the papers by Babitha and John (2013) and Wang et al. (2014). The aim of this paper is to apply hesitant fuzzy ...
Dolmatov Igor Yu IY A. V. Zhirmunsky Institute of Marine Biology, FEB RAS, Palchevsky 17, Vladivostok 690041, Russia ; School of Natural Sciences, Far Eastern Federal University, Suhanova 8, Vladivostok 690950, - - 2014
Aspects of asexual reproduction in holothurians are discussed. Holothurians are significant as fishery and aquaculture items and have high commercial value. The last review on holothurian asexual reproduction was published 18 years ago and included only 8 species. An analysis of the available literature shows that asexual reproduction has now ...
Larson James H JH U.S. Geological Survey, Upper Midwest Environmental Sciences Center, La Crosse, Wisconsin, United States of - - 2014
Freshwater mussels are ecologically and economically important members of many aquatic ecosystems, but are globally among the most imperiled taxa. Propagation techniques for mussels have been developed and used to boost declining and restore extirpated populations. Here we use a cohort of propagated mussels to estimate the intrinsic variability in ...
Rush Catherine M CM Infectious Disease and Immunopathogenesis Research Group, Australian Institute of Tropical Health and Medicine, James Cook University , Townsville, QLD , - - 2014
Rheumatic fever (RF) and rheumatic heart disease (RHD) are sequelae of group A streptococcal (GAS) infection. Although an autoimmune process has long been considered to be responsible for the initiation of RF/RHD, it is only in the last few decades that the mechanisms involved in the pathogenesis of the inflammatory ...
Konijeti Gauree Gupta - - 2013
Recent studies report that the risk of colorectal cancer (CRC) among patients with ulcerative colitis (UC) may be lower than previously estimated. Although white-light endoscopy (WLE) with random biopsies is recommended for dysplasia detection in patients with UC, several studies reported increased detection of dysplasia by chromoendoscopy. To analyze the ...
Yablonskiy Dmitriy A - - 2013
In a recently published paper by Parra-Robles and Wild [1], the authors challenge the in vivo lung morphometry technique (based on hyperpolarized gas diffusion MRI) developed by our Washington University research group. In this Commentary we demonstrate that the main conclusion of Parra-Robles and Wild, that our MRI-based lung morphometry ...
Ghag G G Department of Chemistry and Biochemistry, University of Southern Mississippi, 118 College Dr, # 5043, Hattiesburg, MS 39406, United - - 2013
Protein misfolding and concomitant aggregation towards amyloid formation is the underlying biochemical commonality among a wide range of human pathologies. Amyloid formation involves the conversion of proteins from their native monomeric states (intrinsically disordered or globular) to well-organized, fibrillar aggregates in a nucleation-dependent manner. Understanding the mechanism of aggregation is ...
Helal Mohamed - - 2013
We introduce a mathematical model of the in vivo progression of Alzheimer's disease with focus on the role of prions in memory impairment. Our model consists of differential equations that describe the dynamic formation of [Formula: see text]-amyloid plaques based on the concentrations of A[Formula: see text] oligomers, PrP(C) proteins, and the A[Formula: ...
Fiard Gaelle - - 2013
Introduction-objectives: A virtual-reality learning environment dedicated to prostate biopsies was designed to overcome the limitations of current classical teaching methods. The aim of this study was to validate reliability, face, content and construct of the simulator. Materials and methods: The simulator is composed of a) a laptop computer, b) a ...
Wan Ruijie - - 2013
The aim of the present study was to establish noninvasive diagnostic models of liver fibrosis and assess their predictive accuracy (AC). A total of 349 patients with chronic hepatitis B virus infection were collected, who underwent liver biopsy and pathologic examination at Beijing Ditan Hospital affiliated to Capital Medical University. ...
Kubota Jennifer T - - 2013
Existing stereotypes about Black Americans may influence perceptions of intent during financial negotiations. In this study, we explored whether the influence of race on economic decisions extends to choices that are costly to the decision maker. We investigated whether racial group membership contributes to differential likelihood of rejection of objectively ...
Haas Mark - - 2013
The value of classification systems applied to the examination of renal biopsies is based on several factors: first, on the ability to provide efficient communication between pathologists and between pathologists and clinicians; second, on the possibility to implement diagnostic information with prognostic indication. Even more important, the practical value of ...
Vencalek Ondrej - - 2013
To present a new predictive model for repeated prostate biopsy outcomes. Several practical problems are described that arise when searching for a proper model among those that already exist. A new model is developed with only two explanatory variables and a simple graphical output. This is a retrospective cohort study ...
Rucker D Caleb DC Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235 USA ( daniel.c.rucker@vanderbilt.edu - - 2013
Steerable needles can potentially increase the accuracy of needle-based diagnosis and therapy delivery, provided they can be adequately controlled based on medical image information. We propose a novel sliding mode control law that can be used to deliver the tip of a flexible asymmetric-tipped needle to a desired point, or ...
Busetto Gian Maria - - 2013
To overcome the well-known prostate-specific antigen limits, several new biomarkers have been proposed. Since its introduction in clinical practice, the urinary prostate cancer gene 3 (PCA3) assay has shown promising results for prostate cancer (PC) detection. Furthermore, multiparametric magnetic resonance imaging (mMRI) has the ability to better describe several aspects ...
Yim Sehyuk - - 2013
This paper proposes a new wireless biopsy method where a magnetically actuated untethered soft capsule endoscope (MASCE) carries and releases a large number of thermo-sensitive, untethered micro-grippers (¿-grippers) at a desired location inside the stomach and retrieves them after they self-fold and grab tissue samples. We describe the working principles ...
Macek Petr - - 2013
Objectives: To assess the accuracy of prostate histoscanning (PHS) for spatial detection and localization of PCa. Patients and methods: Prospective, single center study from January to September 2012 was conducted. Inclusion criterion was biopsy confirmed PCa in patients scheduled for radical prostatectomy. Totally, 98 patients were included in the study. ...
Menhadji Ashleigh - - 2013
To improve the understanding of the epidemiology of renal cortical neoplasms through pretreatment biopsy, we evaluated a facilitated ultrasound targeting (FUT) technology. The technology allows a needle to be passed through the transducer probe and guided along a virtual dotted line on the monitor. We compared the FUT with standard percutaneous ...
Hendren Nathaniel - - 2013
Across a wide set of non-group insurance markets, applicants are rejected based on observable, often high-risk, characteristics. This paper argues that private information, held by the potential applicant pool, explains rejections. I formulate this argument by developing and testing a model in which agents may have private information about their ...
Craven Anthea - - 2013
The systemic vasculitides are a group of uncommon diseases characterized by blood vessel inflammation. There are currently no diagnostic criteria for the primary systemic vasculitides and physicians must rely on experience and disease definitions. The absence of validated criteria can result in delays in making the correct diagnosis and starting ...
Emerson Joanne B JB Department of Earth and Planetary Science, University of California, Berkeley, Berkeley, California, - - 2013
It is widely stated that viruses represent the most significant source of biodiversity on Earth, yet characterizing the diversity of viral assemblages in natural systems remains difficult. Viral diversity studies are challenging because viruses lack universally present, phylogenetically informative genes. Here, we developed an approach to estimate viral diversity using ...
Shepherd Jennifer H JH Institute of Bioengineering, School of Engineering and Materials Science, Queen Mary, University of London, London E1 4NS, UK. - - 2013
Tendon injuries, often called tendinopathies, are debilitating and painful conditions, generally considered to develop as a result of tendon overuse. The aetiology of tendinopathy remains poorly understood, and whilst tendon biopsies have provided some information concerning tendon appearance in late-stage disease, there is still little information concerning the mechanical and ...
Xue Lili - - 2013
The lip biopsy is essential for the diagnosis of primary Sjogren's syndrome (SS) but an invasive method can cause some disadvantages. The purpose of this study is to apply Raman spectroscopy to detect the pathological minor salivary glands in primary SS and establish the diagnostic model of Raman spectra of ...
Villard P F - - 2013
   Training in Interventional Radiology currently uses the apprenticeship model, where clinical and technical skills of invasive procedures are learnt during practice in patients. This apprenticeship training method is increasingly limited by regulatory restrictions on working hours, concerns over patient risk through trainees' inexperience and the variable exposure to case mix ...
Serrano-Falcón C - - 2013
Hair and scalp evaluation techniques can be classified into 3 categories: noninvasive methods (clinical history, general examination, inspection and palpation of the hair and scalp, photography, dermoscopy, etc.); semi-invasive methods (the trichogram); and invasive methods (biopsy). In this article, we provide a practical guide on how to evaluate hair and ...
Skums Pavel - - 2013
Highly mutable RNA viruses exist in infected hosts as heterogeneous populations of genetically close variants known as quasispecies. Next-generation sequencing (NGS) allows for analysing a large number of viral sequences from infected patients, presenting a novel opportunity for studying the structure of a viral population and understanding virus evolution, drug ...
Hilton Eric J - - 2013
The prowfish, Zaprora silenus, is the sole member of the family Zaproridae. It is a large, relatively elongate species with a robust head and body, and it feeds primarily on jellyfishes. Although the larvae and juveniles are pelagic, the adults are demersal, and the species is widely distributed from Southern ...
Yim Sehyuk S Department of Mechanical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213 USA ( samy@cmu.edu - - 2013
In this paper, we present a 3-D localization method for a magnetically actuated soft capsule endoscope (MASCE). The proposed localization scheme consists of three steps. First, MASCE is oriented to be coaxially aligned with an external permanent magnet (EPM). Second, MASCE is axially contracted by the enhanced magnetic attraction of ...
Bostwick David G - - 2013
Improved methods such as radiofrequency identification (RFID) are needed to optimize specimen tracking in anatomical pathology. We undertook a study of RFID in an effort to optimize specimen tracking and patient identification, including the following: (1) creation of workflow process maps, (2) evaluation of existing RFID hardware technologies, (3) creation ...
Ardeshir Amir - - 2013
Idiopathic chronic diarrhea (ICD) is a common cause of morbidity and mortality among juvenile rhesus macaques. While lesions may be absent at colonoscopy, the histopathologic evaluation of the biopsy specimens is consistent with human macroscopic colitis (MC). In this study, we developed an isotropic uniform random sampling method to evaluate ...
Veeraraghavalu Karthikeyan - - 2013
Cramer et al. (Reports, 23 March 2012, p. 1503; published online 9 February 2012) reported that bexarotene rapidly reduces β-amyloid (Aβ) levels and plaque burden in two mouse models of Aβ deposition in Alzheimer's disease (AD). We now report that, although bexarotene reduces soluble Aβ40 levels in one of the ...
Nishikawa Robert M - - 2013
RATIONALE AND OBJECTIVES: The goal of this study was to determine the accuracy and precision of using scores from a receiver operating characteristic rating scale to estimate sensitivity and specificity. MATERIALS AND METHODS: We used data collected in a previous study that measured the improvements in radiologists' ability to classify ...
Shirts Brian H - - 2013
BACKGROUND: Interpretation of a diagnostic test result requires knowing what proportion of patients with a "similar" result has the condition in question. This information is often not readily available from the medical literature, or may be based on different clinical populations that make it nonapplicable. In certain settings, where correlated ...
Cardesi E - - 2013
From a solely morphological point of view, histopathological diagnosis is subject to interpretation variables that may be investigated from an epistemological aspect. On the basis of the most suitable ways of approach, the authors examine some theoretical aspects involved in writing a histopathological report. In particular, the following are considered: ...
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