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Semaškienė, Loreta
This doctoral dissertation has been accomplished during the period of 1995-2006 in the Department of Forestry at the Lithuanian University of Agriculture. In Lithuanian forests only one species of genus - small-leaved lime (Tilia cordata Mill.) – is natural. Study aim was to determine the distribution of lime stands in ...
Porter Joshua R JR Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Building 10, Room B1B42, 10 Center Dr., MSC 1500, Bethesda, MD, 20892, - - 2015
This chapter describes approaches for using computational modeling of synthetic biology perturbations to analyze endogenous biological circuits, with a particular focus on signaling and metabolic pathways. We describe a bottom-up approach in which ordinary differential equations are constructed to model the core interactions of a pathway of interest. We then ...
Samavati Navid N Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario M5S 3G9, - - 2014
Biomechanical model based deformable image registration has been widely used to account for prostate deformation in various medical imaging procedures. Biomechanical material properties are important components of a biomechanical model. In this study, the effect of incorporating tumor-specific material properties in the prostate biomechanical model was investigated to provide insight ...
Emblem Kyrre E KE From the Intervention Centre (K.E.E., A.B.), Department of Radiology (P.D.T., J.K.H.), and Department of Neurosurgery (T.R.M.), Oslo University Hospital, N-0027 Sognsvannsveien 20, 0372 Oslo, Norway; Department of Radiology and Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, Mass (K.E.E., M.C.P., O.R.); Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Tex (M.C.P.); Department of Computer Assisted Clinical Medicine, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany (F.G.Z., L.R.S.); and Department of Physics, University of Oslo, Oslo, Norway - - 2014
Purpose To develop a generic support vector machine ( SVM support vector machine ) model by using magnetic resonance (MR) imaging-based blood volume distribution data for preoperative glioma survival associations and to prospectively evaluate the diagnostic effectiveness of this model in autonomous patient data. Materials and Methods Institutional and regional ...
Rottmann Joerg J Brigham and Women's Hospital, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts - - 2014
Precise prediction of respiratory motion is a prerequisite for real-time motion compensation techniques such as beam, dynamic couch, or dynamic multileaf collimator tracking. Collection of tumor motion data to train the prediction model is required for most algorithms. To avoid exposure of patients to additional dose from imaging during this ...
Arnesen Marius Røthe MR Department of Medical Physics, Oslo University Hospital, Norway; Department of Physics, University of Oslo, Norway. Electronic address: - - 2014
This study aims to analyze subsections of the target volume that are sensitive to delineation uncertainties with respect to underdosage (spatial dosimetric uncertainty) in MRI-based brachytherapy of cervical cancer. A methodology was developed to simulate delineation uncertainties by shifting an angular segment of the contour perpendicular to the original HR-CTV. ...
Cai Haoyang H Institute of Molecular Life Sciences, University of Zurich, 8057 Zurich, Switzerland Swiss Institute of Bioinformatics, 8057 Zurich, Switzerland Center of Growth, Metabolism, and Aging, Key Laboratory of Bio-Resources and Eco-Environment, College of Life Sciences, Sichuan University, Chengdu 610064, Sichuan, China - - 2014
Somatic copy number aberrations (CNA) represent a mutation type encountered in the majority of cancer genomes. Here, we present the 2014 edition of arrayMap (http://www.arraymap.org), a publicly accessible collection of pre-processed oncogenomic array data sets and CNA profiles, representing a vast range of human malignancies. Since the initial release, we ...
- - 2014
The laboratory mouse is a key model organism to investigate mechanism and therapeutics of human disease. The number of targeted genetic mouse models of disease is growing rapidly due to high-throughput production strategies employed by the International Mouse Phenotyping Consortium (IMPC) and the development of new, more efficient genome engineering ...
Bouaziz O O MAP5, UMR CNRS 8145, University Paris Descartes, 75006 Paris, France - - 2014
We introduce a covariate-specific total variation penalty in two semiparametric models for the rate function of recurrent event process. The two models are a stratified Cox model, introduced in Prentice and others (1981. On the regression analysis of multivariate failure time data. Biometrika 68: , 373-379.), and a stratified Aalen's ...
Moradi Hamed H Centre of Excellence in Design, Robotics and Automation, School of Mechanical Engineering, Sharif University of Technology, Tehran, Iran. Electronic address: - - 2014
In this paper, an adaptive robust control strategy is developed for the manipulation of drug usage and consequently the tumor volume in cancer chemotherapy. Three nonlinear mathematical cell-kill models including log-kill hypothesis, Norton-Simon hypothesis and Emax hypothesis are considered in the presence of uncertainties. The Lyapunov stability theorem is used ...
Amelot A A Neurosurgery Department, Hôpital Lariboisière, Paris, - - 2014
Biomathematical modeling of glioma growth has been developed to optimize treatments delivery and to evaluate their efficacy. Simulations currently make use of anatomical knowledge from standard MRI atlases. For example, cerebrospinal fluid (CSF) spaces are obtained by automatic thresholding of the MNI atlas, leading to an approximate representation of real ...
Godinho Mariana S MS Universidade Federal de Goiás, PO Box 131, 74001-970 Goiânia, GO, - - 2014
Power transformers are essential components in electrical energy distribution. One of their most important parts is the insulation system, consisting of Kraft paper immersed in insulating oil. Interfacial tension and color are major parameters used for assessing oil quality and the system׳s degradation. This work proposes the use of near ...
Larsson Christopher C The Intervention Centre, Oslo University Hospital, Oslo, - - 2014
To investigate the evolution of T1 in tumor and the necessity of baseline T1 (T1 (0)) mapping for the accurate estimation of kinetic parameters during standard therapy using dynamic contrast enhanced (DCE) MRI in patients with high-grade glioma (HGG). Longitudinal DCE-MRI was performed in 23 patients (196 scans) with confirmed ...
Kiyonari Shinichi S Nagoya University Graduate School of Medicine, Department of Biochemistry , Nagoya , - - 2014
Introduction: Neuroblastoma is the most common extracranial solid tumor in children. It occurs in the adrenosympathetic lineage, which is derived from the neural crest. MYCN amplification is found in about 20% of cases and is the most powerful prognostic factor. Anaplastic lymphoma kinase (ALK) mutation is also found in 7% ...
Zeng Xue-Qiang - - 2014
As a high dimensional problem, analysis of microarray data sets is a challenging task, where many weakly relevant or redundant features affect overall performance of classifiers. The previous works used redundant feature detection methods to select discriminative compact gene set, which only considered the relationship among features, not the redundancy ...
Zhang Yaping Y Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, 90089, - - 2014
FLT3(ITD) subtype acute myeloid leukemia (AML) has a poor prognosis with currently available therapies. A number of small molecule inhibitors of FLT3 and/or CDK4/6 are currently under development. A more complete and quantitative understanding of the mechanisms of action of FLT3 and CDK4/6 inhibitors may better inform the development of ...
Ellis Leigh L Genitourinary Program, Roswell Park Cancer Institute, Buffalo NY, USA ; Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo NY, - - 2014
Progression to metastatic disease is the primary cause of mortality in men with prostate cancer (PCa). Mouse models which progress with spontaneous metastasis are limited. Such models would allow for extensive studies of molecular mechanisms of metastasis, and more definite pre- clinical therapy trials. Orthotopic murine models have been described; ...
Wang Ping P Vanderbilt University Institute of Imaging Science, Department of Radiology & Radiological Sciences, Nashville, TN, - - 2014
Dynamic contrast-enhanced MRI is becoming an increasingly important tool to assess tumors and their response to treatment. In the most common method of computing tumor perfusion parameters, the concentration of the injected contrast agent is first computed in both tumor and blood which is subsequently fit to a perfusion model, ...
Eetezadi Sina S Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College Street, Toronto, Ontario M5S 3M2, Canada. Electronic address: - - 2014
The application of block copolymer micelles (BCMs) in oncology has benefitted from advances in polymer chemistry, drug formulation and delivery as well as in vitro and in vivo biological models. While great strides have been made in each of these individual areas, there remains some disappointment overall, citing, in particular, ...
Carnaval Ana Carolina AC Department of Biology, City College of New York and the Graduate Center of CUNY, 160 Convent Avenue, Marshak Life Science Building J-526, New York, NY 10031, USA - - 2014
Phylogeographic endemism, the degree to which the history of recently evolved lineages is spatially restricted, reflects fundamental evolutionary processes such as cryptic divergence, adaptation and biological responses to environmental heterogeneity. Attempts to explain the extraordinary diversity of the tropics, which often includes deep phylogeographic structure, frequently invoke interactions of climate ...
Wong Serene W H SW Department of Computer Science and Engineering, York University, Toronto, Canada; Princess Margaret Cancer Centre, TECHNA Institute for the Advancement of Technology for Health, UHN, Toronto, - - 2014
While current protein interaction data provides a rich resource for molecular biology, it mostly lacks condition-specific details. Abundance of mRNA data for most diseases provides potential to model condition-specific transcriptional changes. Transcriptional data enables modeling disease mechanisms, and in turn provide potential treatments. While approaches to compare networks constructed from ...
González L M LM Departamento de Estadística, Universidad Nacional de Colombia, Bogotá, Colombia ; Telephone: 57-1-3165000 Ext. 13210. Fax number: 57-1-3165327. Postal address: Ciudad Universitaria, edificio 405, oficina 315, Bogotá, - - 2014
We use a finite population mixed model that accommodates response error in the survey variable of interest and auxiliary information to obtain optimal estimators of population parameters from data collected via simple random sampling. We illustrate the method with the estimation of a regression coefficient and conduct a simulation study ...
Onoma D P DP LITIS EA 4108 - QuantIF, University of Rouen, France; LPNR, UFR-SSMT, University of Cocody, 22 BP 582 Abidjan 22, Côte d'Ivoire. Electronic address: - - 2014
A segmentation algorithm based on the random walk (RW) method, called 3D-LARW, has been developed to delineate small tumors or tumors with a heterogeneous distribution of FDG on PET images. Based on the original algorithm of RW [1], we propose an improved approach using new parameters depending on the Euclidean ...
Liu Yixun Y The Department of Computer Science, Old Dominion University, Norfolk, Virginia - - 2014
This paper presents a nonrigid registration method to align preoperative MRI with intraoperative MRI to compensate for brain deformation during tumor resection. This method extends traditional point-based nonrigid registration in two aspects: (1) allow the input data to be incomplete and (2) simulate the underlying deformation with a heterogeneous biomechanical ...
Solari Aldo A Department of Economics, Management and Statistics, University of Milano-Bicocca, Milan, - - 2014
In observational microarray studies, issues of confounding invariably arise. One approach to account for measured confounders is to include them as covariates in a multivariate linear model. For this model, however, the application of permutation-based multiple testing procedures is problematic because exchangeability of responses, in general, does not hold. Nevertheless, ...
Saddiki Hachem H Department of Biomedical Engineering, Worcester Polytechnic Institute, Worcester, MA, USA School of Science and Engineering, Al Akhawayn University, Ifrane, - - 2014
Genomic analyses of many solid cancers have demonstrated extensive genetic heterogeneity between as well as within individual tumors. However, statistical methods for classifying tumors by subtype based on genomic biomarkers generally entail an all-or-none decision, which may be misleading for clinical samples containing a mixture of subtypes and/or normal cell ...
Kissling Grace E GE National Institute of Environmental Health Science, P.O. Box 12233, Research Triangle Park, NC 27709, United States. Electronic address: - - 2014
A recent article by Gaus (2014) demonstrates a serious misunderstanding of the NTP's statistical analysis and interpretation of rodent carcinogenicity data as reported in Technical Report 578 (Ginkgo biloba) (NTP 2013), as well as a failure to acknowledge the abundant literature on false positive rates in rodent carcinogenicity studies. The ...
Engwer Christian C Institut für Numerische und Angewandte Mathematik, WWU Münster, Münster, Germany, - - 2014
Gliomas are a class of rarely curable tumors arising from abnormal glia cells in the human brain. The understanding of glioma spreading patterns is essential for both radiological therapy as well as surgical treatment. Diffusion tensor imaging (DTI) allows to infer the white matter fibre structure of the brain in ...
Hartung Niklas N I2M UMR7373, Aix-Marseille Université, CNRS, Centrale - - 2014
Defining tumor stage at diagnosis is a pivotal point for clinical decisions regarding patient treatment strategies. In this respect, early detection of occult metastasis invisible to current imaging methods would have a major impact on best care and long-term survival. Mathematical models that describe metastatic spreading might estimate the risk ...
Pierre-Jean Morgane - - 2014
A number of bioinformatic or biostatistical methods are available for analyzing DNA copy number profiles measured from microarray or sequencing technologies. In the absence of rich enough gold standard data sets, the performance of these methods is generally assessed using unrealistic simulation studies, or based on small real data analyses. ...
Wolanski Eric E http://orcid.org/0000-0002-2947-1688 TropWATER, James Cook University, Townsville, Queensland 4811, Australia School of Marine and Tropical Biology, James Cook University, Townsville, Queensland 4811, Australia - - 2014
A predictive model of the fate of coral reef fish larvae in a reef system is proposed that combines the oceanographic processes of advection and turbulent diffusion with the biological process of horizontal swimming controlled by olfactory and auditory cues within the timescales of larval development. In the model, auditory ...
Lum Kristian K Network Dynamics and Simulation Science Laboratory, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, VA, USA - - 2014
We build an agent-based model of incarceration based on the susceptible-infected-suspectible (SIS) model of infectious disease propagation. Our central hypothesis is that the observed racial disparities in incarceration rates between Black and White Americans can be explained as the result of differential sentencing between the two demographic groups. We demonstrate ...
Fisher Charles G CG Division of Spine, Department of Orthopaedics, University of British Columbia and Vancouver CoastalHealth, Vancouver, British - - 2014
Object The National Institutes of Health recommends strategies to obtain evidence for the treatment of rare conditions such as primary tumors of the spine (PTSs). These tumors have a low incidence and are pathologically heterogeneous, and treatment approaches are diverse. Appropriate evidence-based care is imperative. Failure to follow validated oncological ...
Zhang Q Q Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston Salem, NC, - - 2014
The latent class model provides an important platform for jointly modeling mixed-mode data - i.e., discrete and continuous data with various parametric distributions. Multiple mixed-mode variables are used to cluster subjects into latent classes. While the mixed-mode latent class analysis is a powerful tool for statisticians, few studies are focused ...
de With G G *Nuclear Research and Consultancy Group (NRG), Utrechtseweg 310, NL-6800 ES Arnhem, The Netherlands; †Physikalisch-Technische Bundesanstalt (PTB), Bundesallee 100, 38116 Braunschweig, - - 2014
Thoron (Rn) exhalation from building materials has become increasingly recognized as a potential source for radiation exposure in dwellings. However, contrary to radon (Rn), limited information on thoron exposure is available. The purpose of this study is to develop a test method for the determination of the thoron exhalation rate ...
Westerterp Klaas R KR Department of Human Biology, Maastricht University Medical Centre, Maastricht, The - - 2014
Physical activity is the main determinant of variability of individual energy expenditure. Reliable assessment of the activity level of an individual provides information on energy requirement and vital health. Here, evidence is presented on the validity of methods to assess physical activity as applied in health and disease. Improvement of ...
Paull Liam - - 2014
Area coverage with an onboard sensor is an important task for an unmanned aerial vehicle (UAV) with many applications. Autonomous fixed-wing UAVs are more appropriate for larger scale area surveying since they can cover ground more quickly. However, their non-holonomic dynamics and susceptibility to disturbances make sensor coverage a challenging ...
Hidalgo Manuel M Centro Nacional de Investigaciones Oncológicas, Madrid; - - 2014
Recently, there has been an increasing interest in the development and characterization of patient-derived tumor xenograft (PDX) models for cancer research. PDX models mostly retain the principal histologic and genetic characteristics of their donor tumor and remain stable across passages. These models have been shown to be predictive of clinical ...
Lagerlöf Jakob H JH Department of Radiation Physics, Göteborg University, Göteborg 41345, - - 2014
To construct a Monte Carlo (MC)-based simulation model for analyzing the dependence of tumor oxygen distribution on different variables related to tumor vasculature [blood velocity, vessel-to-vessel proximity (vessel proximity), and inflowing oxygen partial pressure (pO2)]. A voxel-based tissue model containing parallel capillaries with square cross-sections (sides of 10 μm) was ...
Poels Kenneth K Department Radiotherapy, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Belgium. Electronic address: - - 2014
For tumor tracking, a correlation model is used to estimate internal tumor position based on external surrogate motion. When patients experience an internal/external surrogate drift, an update of the correlation model is required to continue tumor tracking. In this study, the accuracy of the internal tumor position estimation for both ...
Sinha Shriprakash S Netherlands Bioinformatics Centre, 6500 HB, Nijmegen, The Netherlands. - - 2014
Computational modeling of the Wnt signaling pathway has gained prominence for its use as a diagnostic tool to develop therapeutic cancer target drugs and predict test samples as tumorous/normal. Diagnostic tools entail modeling of the biological phenomena behind the pathway while prediction requires inclusion of factors for discriminative classification. This ...
Voon Siew Hui SH Department of Pharmacology, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, - - 2014
Animal models, particularly rodents, are major translational models for evaluating novel anticancer therapeutics. In this review, different types of nanostructure-based photosensitizers that have advanced into the in vivo evaluation stage for the photodynamic therapy (PDT) of cancer are described. This article focuses on the in vivo efficacies of the nanostructures ...
Khaliq Imran I Biodiversity and Climate Research Centre (BiK-F) and Senckenberg Gesellschaft für Naturforschung, Senckenberganlage 25, 60325 Frankfurt, - - 2014
The relationships among species' physiological capacities and the geographical variation of ambient climate are of key importance to understanding the distribution of life on the Earth. Furthermore, predictions of how species will respond to climate change will profit from the explicit consideration of their physiological tolerances. The climatic variability hypothesis, ...
Lee Sanghoon S Department of Biochemistry, University of Utah, 15 North Medical Drive East, Rm 5800, Salt Lake City, UT, 84112, USA, - - 2014
Gliomas traditionally have been sub-classified based on histopathological observations. However, this approach is subject to inter-observer variability, and histopathological features may not reflect the biological mechanisms that drive tumor growth. High-throughput transcriptional profiling has shown promise in objectively and reproducibly identifying glioma subtypes. Most prior studies have typically used only ...
Scott M M School of Mathematics and Statistics, University of Glasgow, Glasgow, G12 - - 2014
This article moves on to discuss a type of statistical testing different from those we have discussed previously, namely a General Linear Model. This system incorporates a number of other statistical models and is a powerful tool used widely in modern statistics.
Lubke G H GH Department of Psychology,University of Notre - - 2014
Taxometric procedures, model-based clustering and latent variable mixture modeling (LVMM) are statistical methods that use the inter-relationships of observed symptoms or questionnaire items to investigate empirically whether the underlying psychiatric or psychological construct is dimensional or categorical. In this review we show why the results of such an investigation depend ...
Bertolaccini Luca L Thoracic Surgery Unit, Sacro Cuore Hospital, Via Don Angelo Sempreboni 5, 37024, Negrar Verona, Italy, - - 2014
Primary spontaneous pneumothorax (PSP) tends to cluster. Previous studies have found a correlation between PSP and atmospheric pressure variations or thunderstorms. We conducted this study to analyze the PSP correlations with meteorological variables and the concentrations of air pollutants in the city of Cuneo in Italy (IT). We evaluated prospectively ...
Fiedler Goeran G University of Pittsburgh, Pittsburgh, PA, USA - - 2014
It has long been reported that a range of prosthesis alignments is acceptable in trans-tibial prosthetics. This range was shown to be smaller when walking on uneven surfaces. It has also been argued that findings on gait with prostheses that were obtained under laboratory conditions are limited in their applicability ...
Li Haocheng H Department of Statistics, Texas A&M University, 3143, TAMU, College Station, Texas, - - 2014
Motivated by objective measurements of physical activity, we take a functional data approach to longitudinal data with simultaneous measurement of a continuous and a binary outcomes. The regression structures are specified as smooth curves measured at various time-points with random effects that have a hierarchical correlation structure. The random effect ...
Jan Show-Li SL Department of Applied Mathematics, Chung Yuan Christian University, Chungli, Taiwan, 32023, Republic of China, - - 2014
Several viable approaches have been proposed for conducting factorial analysis when the homogeneous variances assumption is violated. Although robust type I error control and excellent power performance are desirable properties of a test procedure for making statistical inferences, the corresponding power calculations must also be considered to extend its applicability ...
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