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Semaškienė, Loreta
This doctoral dissertation has been accomplished during the period of 1995-2006 in the Department of Forestry at the Lithuanian University of Agriculture. In Lithuanian forests only one species of genus - small-leaved lime (Tilia cordata Mill.) – is natural. Study aim was to determine the distribution of lime stands in ...
Godinho Mariana S MS Universidade Federal de Goiás, PO Box 131, 74001-970 Goiânia, GO, - - 2014
Power transformers are essential components in electrical energy distribution. One of their most important parts is the insulation system, consisting of Kraft paper immersed in insulating oil. Interfacial tension and color are major parameters used for assessing oil quality and the system׳s degradation. This work proposes the use of near ...
Zhang Yaping Y Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, 90089, - - 2014
FLT3(ITD) subtype acute myeloid leukemia (AML) has a poor prognosis with currently available therapies. A number of small molecule inhibitors of FLT3 and/or CDK4/6 are currently under development. A more complete and quantitative understanding of the mechanisms of action of FLT3 and CDK4/6 inhibitors may better inform the development of ...
Wang Ping P Vanderbilt University Institute of Imaging Science, Department of Radiology & Radiological Sciences, Nashville, TN, - - 2014
Dynamic contrast-enhanced MRI is becoming an increasingly important tool to assess tumors and their response to treatment. In the most common method of computing tumor perfusion parameters, the concentration of the injected contrast agent is first computed in both tumor and blood which is subsequently fit to a perfusion model, ...
Eetezadi Sina S Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College Street, Toronto, Ontario M5S 3M2, Canada. Electronic address: - - 2014
The application of block copolymer micelles (BCMs) in oncology has benefitted from advances in polymer chemistry, drug formulation and delivery as well as in vitro and in vivo biological models. While great strides have been made in each of these individual areas, there remains some disappointment overall, citing, in particular, ...
Carnaval Ana Carolina AC Department of Biology, City College of New York and the Graduate Center of CUNY, 160 Convent Avenue, Marshak Life Science Building J-526, New York, NY 10031, USA - - 2014
Phylogeographic endemism, the degree to which the history of recently evolved lineages is spatially restricted, reflects fundamental evolutionary processes such as cryptic divergence, adaptation and biological responses to environmental heterogeneity. Attempts to explain the extraordinary diversity of the tropics, which often includes deep phylogeographic structure, frequently invoke interactions of climate ...
Wong Serene W H SW Department of Computer Science and Engineering, York University, Toronto, Canada; Princess Margaret Cancer Centre, TECHNA Institute for the Advancement of Technology for Health, UHN, Toronto, - - 2014
While current protein interaction data provides a rich resource for molecular biology, it mostly lacks condition-specific details. Abundance of mRNA data for most diseases provides potential to model condition-specific transcriptional changes. Transcriptional data enables modeling disease mechanisms, and in turn provide potential treatments. While approaches to compare networks constructed from ...
González L M LM Departamento de Estadística, Universidad Nacional de Colombia, Bogotá, Colombia ; Telephone: 57-1-3165000 Ext. 13210. Fax number: 57-1-3165327. Postal address: Ciudad Universitaria, edificio 405, oficina 315, Bogotá, - - 2014
We use a finite population mixed model that accommodates response error in the survey variable of interest and auxiliary information to obtain optimal estimators of population parameters from data collected via simple random sampling. We illustrate the method with the estimation of a regression coefficient and conduct a simulation study ...
Liu Yixun Y The Department of Computer Science, Old Dominion University, Norfolk, Virginia - - 2014
This paper presents a nonrigid registration method to align preoperative MRI with intraoperative MRI to compensate for brain deformation during tumor resection. This method extends traditional point-based nonrigid registration in two aspects: (1) allow the input data to be incomplete and (2) simulate the underlying deformation with a heterogeneous biomechanical ...
Solari Aldo A Department of Economics, Management and Statistics, University of Milano-Bicocca, Milan, - - 2014
In observational microarray studies, issues of confounding invariably arise. One approach to account for measured confounders is to include them as covariates in a multivariate linear model. For this model, however, the application of permutation-based multiple testing procedures is problematic because exchangeability of responses, in general, does not hold. Nevertheless, ...
Saddiki Hachem H Department of Biomedical Engineering, Worcester Polytechnic Institute, Worcester, MA, USA School of Science and Engineering, Al Akhawayn University, Ifrane, - - 2014
Genomic analyses of many solid cancers have demonstrated extensive genetic heterogeneity between as well as within individual tumors. However, statistical methods for classifying tumors by subtype based on genomic biomarkers generally entail an all-or-none decision, which may be misleading for clinical samples containing a mixture of subtypes and/or normal cell ...
Kissling Grace E GE National Institute of Environmental Health Science, P.O. Box 12233, Research Triangle Park, NC 27709, United States. Electronic address: - - 2014
A recent article by Gaus (2014) demonstrates a serious misunderstanding of the NTP's statistical analysis and interpretation of rodent carcinogenicity data as reported in Technical Report 578 (Ginkgo biloba) (NTP 2013), as well as a failure to acknowledge the abundant literature on false positive rates in rodent carcinogenicity studies. The ...
Engwer Christian C Institut für Numerische und Angewandte Mathematik, WWU Münster, Münster, Germany, - - 2014
Gliomas are a class of rarely curable tumors arising from abnormal glia cells in the human brain. The understanding of glioma spreading patterns is essential for both radiological therapy as well as surgical treatment. Diffusion tensor imaging (DTI) allows to infer the white matter fibre structure of the brain in ...
Hartung Niklas N I2M UMR7373, Aix-Marseille Université, CNRS, Centrale - - 2014
Defining tumor stage at diagnosis is a pivotal point for clinical decisions regarding patient treatment strategies. In this respect, early detection of occult metastasis invisible to current imaging methods would have a major impact on best care and long-term survival. Mathematical models that describe metastatic spreading might estimate the risk ...
Pierre-Jean Morgane - - 2014
A number of bioinformatic or biostatistical methods are available for analyzing DNA copy number profiles measured from microarray or sequencing technologies. In the absence of rich enough gold standard data sets, the performance of these methods is generally assessed using unrealistic simulation studies, or based on small real data analyses. ...
Wolanski Eric E http://orcid.org/0000-0002-2947-1688 TropWATER, James Cook University, Townsville, Queensland 4811, Australia School of Marine and Tropical Biology, James Cook University, Townsville, Queensland 4811, Australia - - 2014
A predictive model of the fate of coral reef fish larvae in a reef system is proposed that combines the oceanographic processes of advection and turbulent diffusion with the biological process of horizontal swimming controlled by olfactory and auditory cues within the timescales of larval development. In the model, auditory ...
Lum Kristian K Network Dynamics and Simulation Science Laboratory, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, VA, USA - - 2014
We build an agent-based model of incarceration based on the susceptible-infected-suspectible (SIS) model of infectious disease propagation. Our central hypothesis is that the observed racial disparities in incarceration rates between Black and White Americans can be explained as the result of differential sentencing between the two demographic groups. We demonstrate ...
Fisher Charles G CG Division of Spine, Department of Orthopaedics, University of British Columbia and Vancouver CoastalHealth, Vancouver, British - - 2014
Object The National Institutes of Health recommends strategies to obtain evidence for the treatment of rare conditions such as primary tumors of the spine (PTSs). These tumors have a low incidence and are pathologically heterogeneous, and treatment approaches are diverse. Appropriate evidence-based care is imperative. Failure to follow validated oncological ...
Zhang Q Q Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston Salem, NC, - - 2014
The latent class model provides an important platform for jointly modeling mixed-mode data - i.e., discrete and continuous data with various parametric distributions. Multiple mixed-mode variables are used to cluster subjects into latent classes. While the mixed-mode latent class analysis is a powerful tool for statisticians, few studies are focused ...
de With G G *Nuclear Research and Consultancy Group (NRG), Utrechtseweg 310, NL-6800 ES Arnhem, The Netherlands; †Physikalisch-Technische Bundesanstalt (PTB), Bundesallee 100, 38116 Braunschweig, - - 2014
Thoron (Rn) exhalation from building materials has become increasingly recognized as a potential source for radiation exposure in dwellings. However, contrary to radon (Rn), limited information on thoron exposure is available. The purpose of this study is to develop a test method for the determination of the thoron exhalation rate ...
Westerterp Klaas R KR Department of Human Biology, Maastricht University Medical Centre, Maastricht, The - - 2014
Physical activity is the main determinant of variability of individual energy expenditure. Reliable assessment of the activity level of an individual provides information on energy requirement and vital health. Here, evidence is presented on the validity of methods to assess physical activity as applied in health and disease. Improvement of ...
Paull Liam - - 2014
Area coverage with an onboard sensor is an important task for an unmanned aerial vehicle (UAV) with many applications. Autonomous fixed-wing UAVs are more appropriate for larger scale area surveying since they can cover ground more quickly. However, their non-holonomic dynamics and susceptibility to disturbances make sensor coverage a challenging ...
Hidalgo Manuel M Centro Nacional de Investigaciones Oncológicas, Madrid; - - 2014
Recently, there has been an increasing interest in the development and characterization of patient-derived tumor xenograft (PDX) models for cancer research. PDX models mostly retain the principal histologic and genetic characteristics of their donor tumor and remain stable across passages. These models have been shown to be predictive of clinical ...
Lagerlöf Jakob H JH Department of Radiation Physics, Göteborg University, Göteborg 41345, - - 2014
To construct a Monte Carlo (MC)-based simulation model for analyzing the dependence of tumor oxygen distribution on different variables related to tumor vasculature [blood velocity, vessel-to-vessel proximity (vessel proximity), and inflowing oxygen partial pressure (pO2)]. A voxel-based tissue model containing parallel capillaries with square cross-sections (sides of 10 μm) was ...
Sinha Shriprakash S Netherlands Bioinformatics Centre, 6500 HB, Nijmegen, The Netherlands. - - 2014
Computational modeling of the Wnt signaling pathway has gained prominence for its use as a diagnostic tool to develop therapeutic cancer target drugs and predict test samples as tumorous/normal. Diagnostic tools entail modeling of the biological phenomena behind the pathway while prediction requires inclusion of factors for discriminative classification. This ...
Voon Siew Hui SH Department of Pharmacology, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, - - 2014
Animal models, particularly rodents, are major translational models for evaluating novel anticancer therapeutics. In this review, different types of nanostructure-based photosensitizers that have advanced into the in vivo evaluation stage for the photodynamic therapy (PDT) of cancer are described. This article focuses on the in vivo efficacies of the nanostructures ...
Khaliq Imran I Biodiversity and Climate Research Centre (BiK-F) and Senckenberg Gesellschaft für Naturforschung, Senckenberganlage 25, 60325 Frankfurt, - - 2014
The relationships among species' physiological capacities and the geographical variation of ambient climate are of key importance to understanding the distribution of life on the Earth. Furthermore, predictions of how species will respond to climate change will profit from the explicit consideration of their physiological tolerances. The climatic variability hypothesis, ...
Lee Sanghoon S Department of Biochemistry, University of Utah, 15 North Medical Drive East, Rm 5800, Salt Lake City, UT, 84112, USA, - - 2014
Gliomas traditionally have been sub-classified based on histopathological observations. However, this approach is subject to inter-observer variability, and histopathological features may not reflect the biological mechanisms that drive tumor growth. High-throughput transcriptional profiling has shown promise in objectively and reproducibly identifying glioma subtypes. Most prior studies have typically used only ...
Scott M M School of Mathematics and Statistics, University of Glasgow, Glasgow, G12 - - 2014
This article moves on to discuss a type of statistical testing different from those we have discussed previously, namely a General Linear Model. This system incorporates a number of other statistical models and is a powerful tool used widely in modern statistics.
Lubke G H GH Department of Psychology,University of Notre - - 2014
Taxometric procedures, model-based clustering and latent variable mixture modeling (LVMM) are statistical methods that use the inter-relationships of observed symptoms or questionnaire items to investigate empirically whether the underlying psychiatric or psychological construct is dimensional or categorical. In this review we show why the results of such an investigation depend ...
Bertolaccini Luca L Thoracic Surgery Unit, Sacro Cuore Hospital, Via Don Angelo Sempreboni 5, 37024, Negrar Verona, Italy, - - 2014
Primary spontaneous pneumothorax (PSP) tends to cluster. Previous studies have found a correlation between PSP and atmospheric pressure variations or thunderstorms. We conducted this study to analyze the PSP correlations with meteorological variables and the concentrations of air pollutants in the city of Cuneo in Italy (IT). We evaluated prospectively ...
Fiedler Goeran G University of Pittsburgh, Pittsburgh, PA, USA - - 2014
It has long been reported that a range of prosthesis alignments is acceptable in trans-tibial prosthetics. This range was shown to be smaller when walking on uneven surfaces. It has also been argued that findings on gait with prostheses that were obtained under laboratory conditions are limited in their applicability ...
Li Haocheng H Department of Statistics, Texas A&M University, 3143, TAMU, College Station, Texas, - - 2014
Motivated by objective measurements of physical activity, we take a functional data approach to longitudinal data with simultaneous measurement of a continuous and a binary outcomes. The regression structures are specified as smooth curves measured at various time-points with random effects that have a hierarchical correlation structure. The random effect ...
Jan Show-Li SL Department of Applied Mathematics, Chung Yuan Christian University, Chungli, Taiwan, 32023, Republic of China, - - 2014
Several viable approaches have been proposed for conducting factorial analysis when the homogeneous variances assumption is violated. Although robust type I error control and excellent power performance are desirable properties of a test procedure for making statistical inferences, the corresponding power calculations must also be considered to extend its applicability ...
Rubenstein Michael M School of Engineering and Applied Sciences and Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, MA 02138, USA. - - 2014
Self-assembly enables nature to build complex forms, from multicellular organisms to complex animal structures such as flocks of birds, through the interaction of vast numbers of limited and unreliable individuals. Creating this ability in engineered systems poses challenges in the design of both algorithms and physical systems that can operate ...
Wilson Ander A Department of Statistics, North Carolina State University, Raleigh, North Carolina 27695, - - 2014
When estimating the effect of an exposure or treatment on an outcome it is important to select the proper subset of confounding variables to include in the model. Including too many covariates increases mean square error on the effect of interest while not including confounding variables biases the exposure effect ...
Yoon Sol Hee SH Dept. of Information and Industrial Engineering, Yonsei University, Seoul, Republic of - - 2014
This research proposes an assessment model for quantifying the perceived visual complexity (PVC) of an in-vehicle instrument cluster. An initial study was conducted to investigate the possibility of evaluating the PVC of an in-vehicle instrument cluster by estimating and analyzing the complexity of its individual components. However, this approach was ...
Ngeo Jimson G - - 2014
Surface electromyography (EMG) signals are often used in many robot and rehabilitation applications because these reflect motor intentions of users very well. However, very few studies have focused on the accurate and proportional control of the human hand using EMG signals. Many have focused on discrete gesture classification and some ...
Altini Marco M Body Area Networks, imec The Netherlands, High Tech Campus 31, Eindhoven, The Netherlands. Signal Processing Systems, Eindhoven University of Technology, Den Dolech 2, Eindhoven, The - - 2014
In this paper we propose a generic approach to reduce inter-individual variability of different physiological signals (HR, GSR and respiration) by automatically estimating normalization parameters (e.g. baseline and range). The proposed normalization procedure does not require a dedicated personal calibration during system setup. On the other hand, normalization parameters are ...
Smolders Roel R VITO, Boeretang 200, Mol B-2400, Belgium. Electronic address: - - 2014
The aim of the current HBM-study is to further the understanding of the impact of inter- and intra-individual variability in HBM surveys as it may have implications for the design and interpretation of the study outcomes. As spot samples only provide a snapshot in time of the concentrations of chemicals ...
Kangas Maarit M Department of Medical Technology, Institute of Biomedicine, University of Oulu, Oulu, - - 2014
Background: About a third of home-dwelling older people fall each year, and institutionalized older people even report a two- or threefold higher rate for falling. Automatic fall detection systems have been developed to support the independent and secure living of the elderly. Even though good fall detection sensitivity and specificity ...
Nielsen Jace C JC Ann Arbor Pharmacometrics Group, Ann Arbor, - - 2014
Vigabatrin is an irreversible inhibitor of γ-aminobutyric acid transaminase (GABA-T) and is used as an adjunctive therapy for adult patients with refractory complex partial seizures (rCPS). The purpose of this investigation was to describe the relationship between vigabatrin dosage and daily seizure rate for adults and children with rCPS and ...
Li Bin - - 2014
Cross-domain collaborative filtering (CF) aims to share common rating knowledge across multiple related CF domains to boost the CF performance. In this paper, we view CF domains as a 2-D site-time coordinate system, on which multiple related domains, such as similar recommender sites or successive time-slices, can share group-level rating ...
Mittal Anuradha A Department of Biomedical Engineering and Center for Biological Systems Engineering and Department of Physics, Washington University in St. Louis One Brookings Drive , Campus Box 1097, St. Louis, Missouri 63130, United - - 2014
There is growing interest in the topic of intrinsically disordered proteins (IDPs). Atomistic Metropolis Monte Carlo (MMC) simulations based on novel implicit solvation models have yielded useful insights regarding sequence-ensemble relationships for IDPs modeled as autonomous units. However, a majority of naturally occurring IDPs are tethered to ordered domains. Tethering ...
Westfall Jacob - - 2014
Researchers designing experiments in which a sample of participants responds to a sample of stimuli are faced with difficult questions about optimal study design. The conventional procedures of statistical power analysis fail to provide appropriate answers to these questions because they are based on statistical models in which stimuli are ...
DeMaris Alfred - - 2014
Unmeasured confounding is the principal threat to unbiased estimation of treatment "effects" (i.e., regression parameters for binary regressors) in nonexperimental research. It refers to unmeasured characteristics of individuals that lead them both to be in a particular "treatment" category and to register higher or lower values than others on a ...
Boef Anna G C AG Department of Clinical Epidemiology, C7-P, Leiden University Medical Centre, PO Box 9600, 2300 RC Leiden, The Netherlands. Electronic address: - - 2014
Instrumental variable (IV) analysis is promising for estimation of therapeutic effects from observational data as it can circumvent unmeasured confounding. However, even if IV assumptions hold, IV analyses will not necessarily provide an estimate closer to the true effect than conventional analyses as this depends on the estimates' bias and ...
Bouchaffra Djamel - - 2014
We introduce a novel formalism that performs dimensionality reduction and captures topological features (such as the shape of the observed data) to conduct pattern classification. This mission is achieved by: 1) reducing the dimension of the observed variables through a kernelized radial basis function technique and expressing the latent variables ...
Malcata Rita M RM High Performance Sport New Zealand, 17 Antares Place, Mairangi Bay, 0632, Auckland, New Zealand, - - 2014
Estimates of the variability that athletes show from competition to competition provide information about the relative contributions of environmental and other factors affecting competitive performance. Smallest and other important thresholds for assessing changes in performance in competitions and field or laboratory tests can also be derived from estimates of variability. ...
Vegezzi Gaia G Department of Pharmacy - University of Parma, Parco Area delle Scienze, 27/A, 43124 Parma - - - 2014
Gastrointestinal (GI) motility disorders include many clinical manifestations associated with various pathologies. They are widespread and can be considered a primary symptom or can be associated to other diseases, such as Parkinson's disease. Understanding the type and site of GI dysmotility is crucial to identify the functional abnormality and to ...
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