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Konur Savas - - 2014
Computational models are perceived as an attractive alternative to mathematical models, e.g. ordinary differential equations. These models incorporate a set of methods for specifying, modelling, testing and simulating biological systems. In addition, they can be analysed using algorithmic techniques, e.g. formal verification. This paper shows how formal verification is utilised ...
Xu Shu - - 2014
Objective: In this study, we aimed to evaluate interrater agreement statistics (IRAS) for use in research on low base rate clinical diagnoses or observed behaviors. Establishing and reporting sufficient interrater agreement is essential in such studies. Yet the most commonly applied agreement statistic, Cohen's κ, has a well known sensitivity ...
Toscano Joseph C - - 2014
A critical issue in assessing speech recognition involves understanding the factors that cause listeners to make errors. Models like the articulation index show that average error decreases logarithmically with increases in signal-to-noise ratio (SNR). We investigated whether (1) this log-linear relationship holds across consonants and for individual tokens, and (2) ...
Charlwood J D JD DBL Centre for Health Research and Development, Faculty of Life, University of Copenhagen, Fredriksberg, Denmark; Instituto Nacional de Saúde, Maputo, Mozambique; MOZDAN (Mozambican-Danish Rural Malaria Project), Morrumbene, Mozambique; Centro de Malária e outras Doenças Tropicais, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Lisbon, - - 2014
Comparisons were undertaken to investigate cost-effective methods of implementing the enzyme-linked immunosorbent assay (ELISA) for sporozoite determination in anophelines when large numbers require processing. Comparisons between ELISA plate reader and visual assessments were performed with Anopheles funestus and Anopheles gambiae s.l. (Diptera: Culicidae), as were comparisons between whole-body mosquito samples, ...
Rastija Vesna - - 2014
In order to find quantitative-structure relationship for the antitrypanosomal activities (against Trypanosma brucei rhodesiense) of polyphenols that belong to the different structural groups, the multiple linear regression (MLR) and artificial neural networks (ANN) were employed. Analysis was performed on the two different size of training set (59 % and 78 ...
Li Na N School of Engineering and Applied Sciences, Harvard University, Cambridge, MA - - 2014
The correlation of healthy states with heart rate variability (HRV) using time series analyses is well documented. Whereas these studies note the accepted proximal role of autonomic nervous system balance in HRV patterns, the responsible deeper physiological, clinically relevant mechanisms have not been fully explained. Using mathematical tools from control ...
Sáez Carlos C Grupo de Informática Biomédica (IBIME), Instituto de Aplicaciones de las Tecnologías de la Información y de las Comunicaciones Avanzadas (ITACA), Universitat Politècnica de València, 46022 València, Spain Center for Health Technology and Services Research (CINTESIS), Faculdade de Medicina da Universidade do Porto, 4200-450, Porto, Portugal - - 2014
Biomedical data may be composed of individuals generated from distinct, meaningful sources. Due to possible contextual biases in the processes that generate data, there may exist an undesirable and unexpected variability among the probability distribution functions (PDFs) of the source subsamples, which, when uncontrolled, may lead to inaccurate or unreproducible ...
Fock Eric - - 2014
A new algorithm for the selection of input variables of neural network is proposed. This new method, applied after the training stage, ranks the inputs according to their importance in the variance of the model output. The use of a global sensitivity analysis technique, extended Fourier amplitude sensitivity test, gives ...
Friesen Melissa C MC Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Rockville, - - 2014
A systematic, transparent, and data-driven approach was developed to estimate frequency and intensity of exposure to straight, soluble, and synthetic/semi-synthetic metalworking fluids (MWFs) within a case-control study of bladder cancer in New England. We assessed frequency using individual-level information from job-specific questionnaires wherever possible, then derived and applied job group-level ...
Lü Chengxu C China Agricultural University, College of Engineering, Beijing 100083, - - 2014
This article presents a novel method for combining auto-peak and cross-peak information for sensitive variable selection in synchronous two-dimensional correlation spectroscopy (2D-COS). This variable selection method is then applied to the case of near-infrared (NIR) microscopy discrimination of meat and bone meal (MBM). This is of important practical value because ...
Shi Tiezhu T School of Resource and Environmental Science and Key Laboratory of Geographic Information System of the Ministry of Education, Wuhan University, 430079, Wuhan, - - 2014
This study, with Yixing (Jiangsu Province, China) and Honghu (Hubei Province, China) as study areas, aimed to compare the successive projection algorithm (SPA) and the genetic algorithm (GA) in spectral feature selection for estimating soil organic carbon (SOC) contents with visible-near-infrared (Vis-NIR) reflectance spectroscopy and further to assess whether the ...
Deng Bai-Chuan BC Department of Chemistry, University of Bergen, Bergen N-5007, - - 2014
In this study, a new optimization algorithm called the Variable Iterative Space Shrinkage Approach (VISSA) that is based on the idea of model population analysis (MPA) is proposed for variable selection. Unlike most of the existing optimization methods for variable selection, VISSA statistically evaluates the performance of variable space in ...
Trendafilov Nickolay T NT Department of Mathematics and Statistics, Open University, Walton Hall, Milton Keynes, MK7 6AA, UK, - - 2014
The component loadings are interpreted by considering their magnitudes, which indicates how strongly each of the original variables relates to the corresponding principal component. The usual ad hoc practice in the interpretation process is to ignore the variables with small absolute loadings or set to zero loadings smaller than some ...
Brouwer Maartje M Division of Environmental Epidemiology, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The - - 2014
Retrospective assessment of environmental pesticide exposure is challenging. Exposure measurements or information on crop-specific pesticide use are often lacking historically. We applied expert assessment to reconstruct historical pesticide use patterns in the Netherlands, and evaluated reliability and accuracy of this procedure. For six main crops in the Netherlands, two experts ...
Gaye Amadou A Department of Health Sciences, University of Leicester, Leicester, UK and UK Biobank and University of Manchester, Manchester, - - 2014
Errors, introduced through poor assessment of physical measurement or because of inconsistent or inappropriate standard operating procedures for collecting, processing, storing or analysing haematological and biochemistry analytes, have a negative impact on the power of association studies using the collected data. A dataset from UK Biobank was used to evaluate ...
Zhou Qingping Q School of Mathematics and Statistics, Lanzhou University, Lanzhou 730000, - - 2014
Exposure to high concentrations of fine particulate matter (PM2.5) can cause serious health problems because PM2.5 contains microscopic solid or liquid droplets that are sufficiently small to be ingested deep into human lungs. Thus, daily prediction of PM2.5 levels is notably important for regulatory plans that inform the public and ...
Ferreira Danton Diego DD Engineering Department, Federal University of Lavras, P. O. Box 3037, 37200-000, Lavras, MG, Brazil. Electronic address: - - 2014
Intermittent photic stimulation (IPS) leads to phase- and time-locked activities in the electroencephalogram (EEG). While the first are easily obtained by means of averaging techniques (the evoked response), this latter reflects changes in the ongoing EEG that are important in Event-Related Synchronization/Desynchronization (ERS/ERD) studies. Techniques have been proposed for assessing ...
Haynes Erin F EF American Institutes for Research, Waltham, Massachusetts - - 2014
An alternative to the spectral overlap assessment metric (SOAM), first introduced by Wassink [(2006). J. Acoust. Soc. Am. 119(4), 2334-2350], is introduced. The SOAM quantifies the intra- and inter-language differences between long-short vowel pairs through a comparison of spectral (F1, F2) and temporal properties modeled with best fit ellipses (F1 × F2 ...
Cao R - - 2014
Two psychophysical experiments were conducted at North Carolina State University (NCSU) and Rochester Institute of Technology (RIT) to obtain replicated perceived saturation data from color normal observers on the order of one unit of saturation. The same 37 Munsell sample sheets, including up to four references that had similar perceived ...
Benzekry Sébastien S Inria Bordeaux Sud-Ouest, Institut de Mathématiques de Bordeaux, Bordeaux, France; Center of Cancer Systems Biology, GRI, Tufts University School of Medicine, Boston, Massachusetts, United States of - - 2014
Despite internal complexity, tumor growth kinetics follow relatively simple laws that can be expressed as mathematical models. To explore this further, quantitative analysis of the most classical of these were performed. The models were assessed against data from two in vivo experimental systems: an ectopic syngeneic tumor (Lewis lung carcinoma) ...
Ding Lucy-Enid LE Pathology North, New South Wales Health Pathology, Royal North Shore Hospital, Sydney, - - 2014
Purpose:The American College of Medical Genetics and Genomics released practice guidelines recommending reporting of incidental findings from exome and whole-genome sequencing by massively parallel (next-generation) sequencing for multiple conditions. Policy statements from other agencies are still being developed, and many attempt to take into consideration the predicted increase in workload ...
Maddess T T Eccles Institute of Neuroscience, John Curtin School of Medical Research, Australian National University, ACT 0200, Canberra, Australia, - - 2014
Our previous studies have shown that in standard automated perimetry (SAP) undersampling occurs if sensitivity varies across a visual field faster than the Nyquist rate (Nq) for the standard sampling interval of 6°. This undersampling was shown to be a major source of test-retest variability. This study first tests some ...
Tang Guo G College of Science, China Agricultural University, Beijing 100193, P.R. China. minsg@263.net - - 2014
The competitive adaptive reweighted sampling-successive projections algorithm (CARS-SPA) method was proposed as a novel variable selection approach to process multivariate calibration. The CARS was first used to select informative variables, and then SPA to refine the variables with minimum redundant information. The proposed method was applied to near-infrared (NIR) reflectance ...
Masten Scott V SV California Department of Motor Vehicles, Research and Development Branch, 2570 24th Street, MS H-126, Sacramento, CA 95818-2606, USA. Electronic address: - - 2014
Self-reports by novice teen drivers in California and elsewhere suggest that many violate graduated driver licensing (GDL) nighttime and passenger restrictions, and to a lesser extent, drive on learner permits without being supervised. Is this corroborated by their traffic conviction records? We examined historical aggregated conviction rates for GDL-related violations ...
Okaie Yutaka - - 2014
This paper describes a mobile bionanosensor network designed for target tracking. The mobile bionanosensor network is composed of bacterium-based autonomous biosensors that coordinate their movement through the use of two types of signaling molecules, repellents and attractants. In search of a target, the bacterium-based autonomous biosensors release repellents to quickly ...
Oliveira Sandra M Da S S SM 1 Universidade do Vale do Sapucaí-Univás - Pouso Alegre/Minas - - 2014
Summary.-This study assessed the quality of the items of the School Anxiety Inventory using the Rating-Scale Rasch model. The Inventory was administered to 253 grade school pupils, ranging in age from 9 to 12 yr. (M = 10.2 yr., SD = 0.98); most were girls (52.8%). The results showed that ...
Lu Ying Y a Beijing University of Technology , Beijing , China , - - 2014
Abstract For approval of generic drugs, the U.S. Food and Drug Administration requires the evidence of bioequivalence in average bioavailability be provided. Based on the Fundmental Bioequivalence Assumption from FDA that if two drug products are shown to be bioequivalent, it is assumed that they are therapeutically equivalent and can ...
Maletić Dimitrije M DM Institute of Physics, University of Belgrade, Pregrevica 118, 11080 Zemun, Serbia - - 2014
The results of analysis using correlative and multivariate methods, as developed for data analysis in high-energy physics and implemented in the Toolkit for Multivariate Analysis software package, of the relations of the variation of increased radon concentration with climate variables in shallow underground laboratory is presented. Multivariate regression analysis identified ...
Almeida Fabio F Laboratório de Parasitologia, Instituto Butantan, Avenida Vital Brasil 1500, CEP 05503-900, São Paulo, Brazil. Electronic address: - - 2014
Anopheles darlingi Root is the principal vector of Plasmodium in Brazil, but its biological variability is not well known. Morphometric analyses of scanning electron microscopy images of the eggs of An. darlingi were conducted using individuals collected in nine states of Brazil (Acre, Amapá, Espírito Santo, Pará, Paraná, Rio de ...
Shao Xingling X Unmanned Aerial Vehicle Research Institute, Beijing University of Aeronautics and Astronautics, Beijing 100191, China; Science and Technology on Aircraft Control Laboratory, Beijing University of Aeronautics and Astronautics, Beijing 100191, - - 2014
This paper investigates a novel compound control scheme combined with the advantages of trajectory linearization control (TLC) and alternative active disturbance rejection control (ADRC) for hypersonic reentry vehicle (HRV) attitude tracking system with bounded uncertainties. Firstly, in order to overcome actuator saturation problem, nonlinear tracking differentiator (TD) is applied in ...
Huo Ji-Xiang JX College of Earth Science and Engineering, Hohai University, Nanjing 210098, - - 2014
The multi-component reactive transport model is widely used in contaminant transport, water-rock interaction, and other earth science fields. Since its complexity lies in its solution, a decoupling approach is used to simplify the model to enhance computational efficiency. A decoupling approach is presented for heterogeneous media, and used to solve ...
Sibley Kathryn M KM Toronto Rehabilitation Institute- University Health Network; Department of Physical Therapy, University of - - 2014
To identify components of postural control included in standardized balance measures for adult populations. Electronic searches of Medline, Embase, and CINAHL databases using key word combinations of postural balance/ equilibrium, psychometrics/ reproducibility of results/ predictive value of tests/ validation studies, instrument construction/ instrument validation, geriatric assessment/ disability evaluation, grey literature ...
Shayegh F F Digital Signal Processing Lab, Department of Electrical and Computer Engineering, Isfahan University of Technology , Isfahan , - - 2014
In this paper, a model-based approach is presented to quantify the effective synchrony between hippocampal areas from depth-EEG signals. This approach is based on the parameter identification procedure of a realistic Multi-Source/Multi-Channel (MSMC) hippocampal model that simulates the function of different areas of hippocampus. In the model it is supposed ...
MacKinnon David P DP Arizona State University, Tempe, USA - - 2014
Statistical mediation methods provide valuable information about underlying mediating psychological processes, but the ability to infer that the mediator variable causes the outcome variable is more complex than widely known. Researchers have recently emphasized how violating assumptions about confounder bias severely limits causal inference of the mediator to dependent variable ...
Fourment Mathieu - - 2014
BackgroundEarly methods for estimating divergence times from gene sequence data relied on the assumption of a molecular clock. More sophisticated methods were created to model rate variation and used auto-correlation of rates, local clocks, or the so called ¿uncorrelated relaxed clock¿ where substitution rates are assumed to be drawn from ...
Lazure Patrice - - 2014
The Theoretical Domains Framework (TDF) is a set of 14 domains of behavior change that provide a framework for the critical issues and factors influencing optimal knowledge translation. Considering that a previous study has identified optimal knowledge translation techniques for each TDF domain, it was hypothesized that the TDF could ...
Berendsen Brenda Aj - - 2014
Health is associated with amount of daily physical activity. Recently, the identification of sedentary time as an independent factor, has gained interest. A valid and easy to use activity monitor is needed to objectively investigate the relationship between physical activity, sedentary time and health. We compared validity and reproducibility of ...
Zhang Zhao Z State Key Laboratory of Earth Surface Processes and Resources Ecology/Key Laboratory of Environmental Change and Natural Disaster, MOE/Academy of Disaster Reduction and Emergency Management, Beijing Normal University, Beijing, 100875, China, - - 2014
Although many studies have indicated the consistent impact of warming on the natural ecosystem (e.g., an early flowering and prolonged growing period), our knowledge of the impacts on agricultural systems is still poorly understood. In this study, spatiotemporal variability of the heading-flowering stages of single rice was detected and compared ...
Roth Wolff-Michael WM Faculty of Education, University of Victoria; Griffith Institute of Educational Research, Griffith - - 2014
Research into expertise is relatively common in cognitive science concerning expertise existing across many domains. However, much less research has examined how experts within the same domain assess the performance of their peer experts. We report the results of a modified think-aloud study conducted with 18 pilots (6 first officers, ...
O'Farrell Hayley H Department of Mathematics, University of Surrey, Guildford, Surrey, GU2 7XH, - - 2014
We present mathematical models for the midge-borne disease bluetongue, with cattle and sheep as hosts. The models take the form of delay differential equations and incorporate the incubation time of bluetongue in cattle, sheep and midges, and also the larval developmental time of midges. Recovery in cattle and sheep is ...
Ergin Dilek D Celal Bayar University, Manisa, Turkey - - 2014
Purpose. The objective of this study was to assess the reliability and validity of the Oncology module of the generic KINDL scale (having 24 items with 6 domains). Methods. The psychometric properties of the KINDL Oncology module were evaluated from the aspect of internal consistency, reliability, and construct validity on ...
Kchaou Mourad M Laboratory of Sciences and Techniques of Automatic Control & Computer Engineering (Lab-STA), National School of Engineering of Sfax, University of Sfax, Postal Box 1173, 3038 Sfax, Tunisia. Electronic address: - - 2014
In this paper, we investigate the problem of non-fragile H∞ fuzzy control design for continuous Takagi Sugeno (T-S) fuzzy systems with uncertainties, external disturbance and unmeasurable state variables. For the case of controller and observer gain additive variations, we propose a new solution of the fragility problem by developing the ...
Boef Anna G C AG From the aDepartment of Clinical Epidemiology; bDepartment of Intensive Care; cDepartment of Medical Statistics and Bioinformatics; and dDepartment of Endocrinology and Metabolic Diseases, Leiden University Medical Centre, Leiden, The - - 2014
Instrumental variable methods can potentially circumvent the unmeasured confounding inherent in observational data analyses. We investigated the validity and usefulness of physician's preference instrumental variable analysis in the setting of a moderate-sized clinical study. Using routine care data from 476 elective cardiac surgery patients, we assessed the effect of preoperative ...
VanderWeele Tyler J TJ From the Departments of Epidemiology and Biostatistics, Harvard School of Public Health, Boston, - - 2014
A framework is presented that allows an investigator to estimate the portion of the effect of one exposure that is attributable to an interaction with a second exposure. We show that when the 2 exposures are statistically independent in distribution, the total effect of one exposure can be decomposed into ...
Frølich Laura L Section for Cognitive Systems, DTU Compute, Technical University of Denmark, Lyngby, - - 2014
In this study, we aim to automatically identify multiple artifact types in EEG. We used multinomial regression to classify independent components of EEG data, selecting from 65 spatial, spectral, and temporal features of independent components using forward selection. The classifier identified neural and five nonneural types of components. Between subjects ...
Livesay R J RJ Mason Livesay Scientific, LLC, 1519 Fremont Place, Knoxville, TN 37917, United States. Electronic address: - - 2014
A complete understanding of both the steady state and transient background measured by Radiation Portal Monitors (RPMs) is essential to predictable system performance, as well as maximization of detection sensitivity. To facilitate this understanding, a test bed for the study of natural background in RPMs has been established at the ...
Kim Hyungjin H Department of Radiology, Seoul National University College of Medicine, 101 Daehangno, Jongno-gu, Seoul, 110-744, South - - 2014
To compare the pulmonary subsolid nodule (SSN) classification agreement and measurement variability between filtered back projection (FBP) and model-based iterative reconstruction (MBIR). Low-dose CTs were reconstructed using FBP and MBIR for 47 patients with 47 SSNs. Two readers independently classified SSNs into pure or part-solid ground-glass nodules, and measured the ...
Schoville Benjamin J BJ Institute of Human Origins, School of Human Evolution and Social Change, Arizona State University, Tempe, AZ 85287, USA. Electronic address: - - 2014
Zooarchaeologists frequently use the relative abundance of skeletal elements in faunal assemblages in conjunction with foraging theory models to infer subsistence decisions made by prehistoric hunter-gatherers. However, foraging models applied to ethnoarchaeological cases have had variable success linking skeletal transport decisions with foraging predictions. Here, we approach this issue with ...
Junkes-Cunha Maíra - - 2014
Functional evaluation of sit-to-stand and stand-to-sit activities is often used by physiotherapists in patients with neurological and musculoskeletal disorders. The observation of the way these activities are executed is essential in identifying kinesiological problems. There are different methodologies used to describe the stand-to-sit activity and its evaluation is not yet ...
Hu Chuanpu C Pharmacokinetics and Pharmacometrics, Biologics Clinical Pharmacology, Janssen Research and Development, LLC, 1400 McKean Road, PO Box 776, Spring House, PA, 19477, USA, - - 2014
Informative exposure-response modeling of clinical endpoints is important in drug development. There has been much recent progress in latent variable modeling of ordered categorical endpoints, including the application of indirect response (IDR) models and accounting for residual correlations between multiple categorical endpoints. This manuscript describes a framework of latent-variable-based IDR ...
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