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Edwards Howell G M HG Centre for Astrobiology and Extremophiles Research, Chemical and Forensic Sciences, School of Life Sciences, University of Bradford, Bradford BD7 1DP, UK - - 2014
This paper draws a comparison between the 700-year-old historically reported will-o'-the-wisp phenomenon and the more recent discovery of extremophilic colonization of hostile environments; both have been observed as present in isolated, stressed environmental regions and originating from biological phenomena. However, whereas extremophilic activity can be understood in terms of a ...
Varnali Tereza T Department of Chemistry, Bogazici University, Istanbul, Turkey - - 2014
Raman spectroscopy has been identified as an important first-pass analytical technique for deployment on planetary surfaces as part of a suite of instrumentation in projected remote space exploration missions to detect extant or extinct extraterrestrial life signatures. Aside from the demonstrable advantages of a non-destructive sampling procedure and an ability ...
Carboni Lucia L Department of Pharmacy and Biotechnology, Alma Mater Studiorum University of - - 2014
The neurobiological basis of major depressive disorder (MDD) is only partially understood. The proposed hypotheses postulate dysregulations of monoaminergic and other neurotransmitter pathways, impaired stress responses, insufficient neurogenetic and neurotrophic processes generating maladaptive neuroplasticity, inappropriate inflammatory and metabolic responses. Proteomic approaches can provide useful contributions to the investigation of the ...
Baruth Meghan M 1Department of Health Science,Saginaw Valley State University,7400 Bay Road,University Center,MI - - 2014
Performing and publishing mediator analyses, whether significant or null, provides insight into where research efforts should focus and will assist in developing effective and powerful behaviour change interventions. The present study examined whether self-efficacy, social support and church support mediated changes in leisure-time physical activity (PA) and fruit and vegetable ...
Posen I Daniel - - 2014
The narrow scope of the U.S. renewable fuel standard (RFS2) is a missed opportunity to spur a wider range of biomass use. This is especially relevant as RFS2 targets are being missed due to demand-side limitations for ethanol consumption. This paper examines the greenhouse gas (GHG) implications of a more ...
Gajewicz Agnieszka A Laboratory of Environmental Chemometrics, Institute for Environmental and Human Health Protection, Faculty of Chemistry, University of Gdansk, Gdansk, - - 2014
Creating suitable chemical categories and developing read-across methods, supported by quantum mechanical calculations, can be an effective solution to solving key problems related to current scarcity of data on the toxicity of various nanoparticles. This study has demonstrated that by applying a nano-read-across, the cytotoxicity of nano-sized metal oxides could ...
Shin Andrew A Department of Ophthalmology, UCLA, Jules Stein Eye Institute, Los Angeles, CA, 90095, United - - 2014
Purpose: Z-myotomy is an extraocular muscle (EOM) weakening procedure in which two incisions are made from longitudinally-separated, opposite EOM margins for treatment of strabismus. We examined the biomechanics of Z-myotomy using tensile loading. Methods: Fresh bovine rectus EOMs were reduced to 20x10x2mm dimensions, and clamped in a micro-tensile load cell ...
Sadoul B B INRA, LPGP Fish Physiology and Genomics UR1037, Rennes, France. Electronic address: - - 2014
Robustness is a complex trait difficult to characterize and phenotype. In the present study, two features of robustness in rainbow trout were investigated: sensitivity and resilience to an acute stressor. For that purpose, oxygen consumption, cortisol release, group dispersion and group activity of two isogenic lines of juvenile rainbow trout ...
Schubert M M Empa, Swiss Federal Laboratories for Materials Science and Technology, Laboratory for Applied Wood Materials, Lerchenfeldstrasse 5, CH-9014St. Gallen, Switzerland. Electronic address: - - 2014
An artificial neural network (ANN) and genetic algorithm (GA) were applied to improve the laccase-mediated oxidation of iodide (I(-)) to elemental iodine (I2). Biosynthesis of iodine (I2) was studied with a 5-level-4-factor central composite design (CCD). The generated ANN network was mathematically evaluated by several statistical indices and revealed better ...
Nagy Péter P Department of Anatomy, Cell and Developmental Biology, Eötvös Loránd University, Pázmány s. 1/C. 6.520. Budapest, H-1117 - - 2014
During the catabolic process of autophagy, cytoplasmic material is transported to the lysosome for degradation and recycling. This way, autophagy contributes to the homeodynamic turnover of proteins, lipids, nucleic acids, glycogen, and even whole organelles. Autophagic activity is increased by adverse conditions such as nutrient limitation, growth factor withdrawal and ...
Ghafoori Samira S Department of Chemical Engineering, Ryerson University, 350 Victoria St., Toronto, Ontario, Canada M5B - - 2014
The merits of the sonophotolysis as a combination of sonolysis (US) and photolysis (UV/H2O2) are investigated in a pilot-scale external loop airlift sonophotoreactor for the treatment of a synthetic pharmaceutical wastewater (SPWW). In the first part of this study, the multivariate experimental design is carried out using Box-Behnken design (BBD). ...
Mariani Melisa L ML INTEC (Universidad Nacional del Litoral and CONICET), Güemes 3450, 3000 Santa Fe, Argentina. - - 2014
The UV/H2O2 process was applied to the treatment of different mixtures of herbicides in water. Glyphosate, the herbicide most used in the world, was mixed with other hormonal herbicides with residual activity as 2,4-D and dicamba. The main goals of the study were to develop a kinetic model for interpreting ...
Camp E V EV School of Forest Resources and Conservation, Fisheries and Aquatic Sciences Program, University of Florida, 7922 NW 71st Street, Gainesville, FL 32605, - - 2014
An integrated socioecological model was developed to evaluate the potential for stock enhancement with hatchery fishes to achieve socioeconomic and conservation objectives in recreational fisheries. As a case study, this model was applied to the red drum Sciaenops ocellatus recreational fishery in the Tampa Bay estuary, Florida, U.S.A. The results ...
Kremling A A Fachgebiet für Systembiotechnologie, Technische Universität München, Boltzmannstrasse 15, 85748 Garching, Germany. Electronic address: - - 2014
Carbon catabolite repression (CCR) controls the order in which different carbon sources are metabolized. Although this system is one of the paradigms of the regulation of gene expression in bacteria, the underlying mechanisms remain controversial. CCR involves the coordination of different subsystems of the cell that are responsible for the ...
Pearl Judea - - 2014
This comment clarifies how structural causal models unify the graphical and potential outcome approaches to mediation, and why the resulting mediation formulas are identical in both frameworks. It further explains under what conditions ignorability-based assumptions are over-restrictive and why such assumptions require graphical interpretations before they can be judged for ...
Crofton Elizabeth J EJ Center for Addiction Research, Mitchell Center for Neurodegenerative Diseases, Department of Pharmacology and Toxicology, University of Texas Medical Branch, 301 University Blvd., Galveston, TX 77555, United - - 2014
One hallmark of psychiatric conditions is the vast continuum of individual differences in susceptibility vs. resilience resulting from the interaction of genetic and environmental factors. The environmental enrichment paradigm is an animal model that is useful for studying a range of psychiatric conditions, including protective phenotypes in addiction and depression ...
Warnecke Andreas - - 2014
BackgroundPost-translational modifications (PTMs) constitute a major aspect of protein biology, particularly signaling events. Conversely, several different pathophysiological PTMs are hallmarks of oxidative imbalance or inflammatory states and are strongly associated with pathogenesis of autoimmune diseases or cancers. Accordingly, it is of interest to assess both the biological and structural effects ...
Edgar Lowell T LT Department of Bioengineering, University of Utah, 72 South Central Campus Drive, Rm 2646, Salt Lake City, UT, 84112, - - 2014
During angiogenesis, sprouting microvessels interact with the extracellular matrix (ECM) by degrading and reorganizing the matrix, applying traction forces, and producing deformation. Morphometric features of the resulting microvascular network are affected by the interaction between the matrix and angiogenic microvessels. The objective of this study was to develop a continuous-discrete ...
David Stephanie S Université François-Rabelais de Tours, Nanomédicaments et Nanosondes, EA 6295, Tours, France. Electronic address: - - 2014
Short interfering RNAs (siRNAs) appear to be a promising tool to treat various human diseases, such as cancer via the RNA interference (RNAi) mechanism. Since the systemic administration of siRNAs is limited by their capacity to attain the site of action, novel delivery systems are needed. Previously, we reported the ...
Sonnhammer Erik L L EL Stockholm Bioinformatics Center, Department of Biochemistry and Biophysics, Stockholm University, Science for Life Laboratory, Box 1031, SE-17121 Solna, Sweden - - 2014
The InParanoid database (http://InParanoid.sbc.su.se) provides a user interface to orthologs inferred by the InParanoid algorithm. As there are now international efforts to curate and standardize complete proteomes, we have switched to using these resources rather than gathering and curating the proteomes ourselves. InParanoid release 8 is based on the 66 ...
Murthy Venkatesh Locharla VL University of - - 2014
The quantification of myocardial blood flow (MBF) and myocardial flow reserve (MFR) using PET with (82)Rb in patients with known or suspected coronary artery disease has been demonstrated to have substantial prognostic and diagnostic value. However, multiple methods for estimation of an image-derived input function and several models for the ...
Lim Diane C DC http://orcid.org/0000-0001-5748-629X University of Pennsylvania - - 2014
Mouse models of cyclical intermittent hypoxia (CIH) are used to study the consequences of both hypoxia and oxidative stress in obstructive sleep apnea (OSA). Whether or not a mouse model of CIH that simulates OSA patients' oxygenation characteristics would translate into improved patient care remains unanswered. First we identified oxygenation ...
Mayer Brooke K BK Marquette University, P.O. Box 1881, Milwaukee, WI 53201-1881, United States. Electronic address: - - 2014
Advanced oxidation processes (AOPs) are gaining traction as they offer mineralization potential rather than transferring contaminants between media. However, AOPs operated with limited energy and/or chemical inputs can exacerbate disinfection byproduct (DBP) formation, even as precursors such as dissolved organic carbon, UV254, and specific UV absorbance (SUVA) decrease. This study ...
Fan Senqing S School of Chemical Engineering, Sichuan University, 610065 Chengdu, - - 2014
Unstructured kinetic models were proposed to describe the principal kinetics involved in ethanol fermentation in a continuous and closed-circulating fermentation (CCCF) process with a pervaporation membrane bioreactor. After ethanol was removed in situ from the broth by the membrane pervaporation, the secondary metabolites accumulated in the broth became the inhibitors ...
Otovic Pete P Johns Hopkins University, Research Animal Resources, Baltimore, MD, - - 2014
HPA axis activity is often measured by corticosteroid release as a means to evaluate stress and well-being in animals. While the analysis of corticosteroid levels can provide useful information in some circumstances, a variety of methodological and technical problems make them difficult to accurately interpret. Furthermore, there is considerable evidence ...
McIntosh Grant J - - 2014
The dominant formation mechanisms of chlorinated phenylacetylenes, naphthalenes, and phenylvinylacetylenes in relatively low pressure and temperature (~40 Torr and 1000 K) pyrolysis systems are explored. Mechanism elucidation is achieved through a combination of theoretical and experimental techniques, the former employing a novel simplification of kinetic modeling which utilizes rate constants ...
Moinzadeh Amir T AT Departments of Endodontology and Dental Material Science, Academic Centre for Dentistry Amsterdam (ACTA), Amsterdam, the - - 2014
Back in 2008, a letter entitled "New directions in old leakage models…" (De-Deus 2008) was published in the International Endodontic Journal (IEJ). The author stressed the necessity of establishing the "clinical significance of endodontic leakage models" rather than "undertaking the simple comparisons of the sealing ability of endodontic materials or ...
Beridze George - - 2014
Ability to perform a feasible and reliable computation of thermochemical properties of chemically complex actinide-bearing materials would be of great importance for nuclear engineering. Unfortunately, density functional theory (DFT), which on many instances is the only affordable {\it ab initio} method, often fails for actinides. Among various shortcomings, it leads ...
Nagasree Kurre Purna KP Pharmaceutical Chemistry Research Labs, University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam - 530 003 A.P., India. - - 2014
Thiazolidine-4-carboxylic acid derivatives were recognized recently for their potent antitubercular activity. A total of sixty four thiazolidine derivatives published in the recent times were collected and 3D QSAR models were developed using CoMFA and COMSIA with high predictability. Later, we selected three new molecules synthesized recently in our lab and ...
Zhang X X International Maize and Wheat Improvement Center (CIMMYT), Mexico, - - 2014
One of the most important applications of genomic selection in maize breeding is to predict and identify the best untested lines from biparental populations, when the training and validation sets are derived from the same cross. Nineteen tropical maize biparental populations evaluated in multienvironment trials were used in this study ...
Beheshti Sayyed-Mohsen SM a School of Mechanical Engineering , Iran University of Science and Technology , 16765-163 Tehran , - - 2014
Abstract Gasification is a thermochemical process in which solid or liquid fuels are transformed into synthesis gas through partial oxidation. In this paper, a kinetic model of rice husk gasification has been developed, which is interesting for the applications of the syngas produced. It is a zero dimensional, steady state ...
Montzka Stephen A - - 2014
Global-scale atmospheric measurements are used to investigate the effectiveness of recent adjustments to production and consumption controls on hydrochlorofluorocarbons (HCFCs) under the Montreal Protocol on Substances that Deplete the Ozone Layer (Montreal Protocol) and to assess recent projections of large increases in hydrofluorocarbon (HFC) production and emission. The results show ...
Liu Zhen - - 2014
Current knowledge of daytime HONO sources remains incomplete. A large missing daytime HONO source has been found in many places around the world, including polluted regions in China. Conventional understanding and recent studies attributed this missing source mainly to ground surface processes or gas-phase chemistry, while assuming aerosols to be ...
Gasteazoro F F Departamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Morelos, México. Av. Universidad #2001, Col Chamilpa C.P.62210 Cuernavaca, - - 2014
Ethylene is a key molecule in organic synthesis currently produced by steam cracking of fossil hydrocarbons. In nature, ethylene is produced in higher plants by 1-aminocyclopropane-1-carboxylic acid oxidase (ACCO). Biocatalytic alternatives for ethylene production are still far from being competitive with traditional production plants. Furthermore, data dispersion shown in the ...
Gallejones P P Basque Centre for Climate Change (BC3), 48008 Bilbao, Spain. Electronic address: - - 2014
This paper presents an alternative approach to assess the impacts of biofuel production using a method integrating the simulated values of a new semi-empirical model at the crop production stage within a life cycle assessment (LCA). This new approach enabled us to capture some of the effects that climatic conditions ...
Hackbarth S S Humboldt-Universität zu Berlin, Institute of Physics, Photobiophysics, Newtonstr. 15, 12489 Berlin, Germany. hacky@physik.hu-berlin.de - - 2014
In vivo measurement of singlet oxygen luminescence kinetics is affected by the heterogeneity of biological samples. Even though singlet oxygen luminescence detection is technically getting easier, the analysis of signals from biological samples is still far from quantitative real time surveillance as it is aspired by the community. In this ...
Mbuthia Jackson M JM Animal Breeding and Genomics Group, Department of Animal Sciences, Egerton University, P.O. Box 536-20115, Egerton, - - 2014
A deterministic bio-economic model was developed and applied to evaluate biological and economic variables that characterize smallholder pig production systems in Kenya. Two pig production systems were considered namely, semi-intensive (SI) and extensive (EX). The input variables were categorized into biological variables including production and functional traits, nutritional variables, management ...
Malik Arunima A ISA, School of Physics A28, The University of Sydney, NSW 2006, Australia. Electronic address: - - 2014
The objective of this work is to establish whether algal bio-crude production is environmentally, economically and socially sustainable. To this end, an economic multi-regional input-output model of Australia was complemented with engineering process data on algal bio-crude production. This model was used to undertake hybrid life-cycle assessment for measuring the ...
Wang Tan - - 2014
This paper investigates the removal characteristics of the multigesture jetting of magnetorheological jet polishing (MJP). It discusses four main jetting models that satisfy precise polishing, which are complemented by an integrated polishing tool. Based on fluid impact dynamics theory, the paper analyzes the characteristics of abrasives in flowing slurry, such ...
Johnson Lee L 1] EastChem, School of Chemistry, University of St Andrews, North Haugh, St Andrews, Fife KY16 9ST, UK [2] Departments of Materials, University of Oxford, Parks Road, Oxford OX1 3PH, - - 2014
When lithium-oxygen batteries discharge, O2 is reduced at the cathode to form solid Li2O2. Understanding the fundamental mechanism of O2 reduction in aprotic solvents is therefore essential to realizing their technological potential. Two different models have been proposed for Li2O2 formation, involving either solution or electrode surface routes. Here, we ...
Concu Riccardo - - 2014
The main objective of this study was to simulate for the first time a complex sol-gel system aimed at preparing the S-Naproxen imprinted xerogel with an explicit representation of all the ionic species at pH 9. To this purpose, a series of molecular dynamics (MD) simulations of different mixtures, including ...
Noordally Zeenat B - - 2014
As major contributors to global oxygen levels and producers of fatty acids, carotenoid, sterols and phycocolloids, algae have significant ecological and commercial roles. Early algal models have contributed much to our understanding of circadian clocks at physiological and biochemical levels. The genetic and molecular approaches that identified clock components in ...
Bali Anjana A Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, Patiala-147002 India. Electronic address: - - 2014
Stress is a state of threatened homeostasis during which a variety of adaptive processes are activated to produce physiological and behavioral changes. Preclinical models are pivotal for understanding these physiological or pathophysiological changes in the body in response to stress. Furthermore, these models are also important for the development of ...
Wallace Jack J Department of Civil Engineering, Queen's University, Ellis Hall, 58 University Avenue, Kingston, Ontario K7L 3N6, Canada. Electronic address: - - 2014
A pilot-scale hybrid-passive treatment system operated at the Merrick Landfill in North Bay, Ontario, Canada, treats municipal landfill leachate and provides for subsequent natural attenuation. Collected leachate is directed to a hybrid-passive treatment system, followed by controlled release to a natural attenuation zone before entering the nearby Little Sturgeon River. ...
Smusz Sabina S Department of Medicinal Chemistry, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Kraków 31-343, Poland; Faculty of Chemistry, Jagiellonian University, R. Ingardena 3, Kraków 30-060, - - 2014
The great majority of molecular modeling tasks require the construction of a model that is then used to evaluate new compounds. Although various types of these models exist, at some stage, they all use knowledge about the activity of a given group of compounds, and the performance of the models ...
Nganai Shadrack - - 2014
The discrepancies between polychlorinated dibenzo-p-dioxin to polychlorinated dibenzofuran (PCDD to PCDF) ratios in laboratory and field studies in the exhaust of combustion sources are not fully explained by available formation models. In this paper we present the results of experimental studies of the surface mediated formation of PCDD/F at the ...
Toropova Alla P AP IRCCS, Istituto di Ricerche Farmacologiche Mario Negri, Via La Masa 19, 20156 Milano, - - 2014
The Monte Carlo technique has been used to build up quantitative structure-activity relationships (QSARs) for prediction of dark cytotoxicity and photo-induced cytotoxicity of metal oxide nanoparticles to bacteria Escherichia coli (minus logarithm of lethal concentration for 50% bacteria pLC50, LC50 in mol/L). The representation of nanoparticles include (i) in the ...
Jahromi Samaneh Reiszadeh SR DST Unit on Evolution and Genetics, Department of Studies in Zoology, University of Mysore, Manasagangotri, Mysore, Karnataka, - - 2014
Over expression of human α-synuclein gene in Drosophila can reduce lifespan and we have performed lifespan assay for A30P and A53Tα-synuclein transgenic and control (elav-GAL4, UAS-A30P, UAS-A53T) flies. Our results showed reduced lifespan of transgenic flies compared to controls. We have also investigated behavioral responses, levels of ROS (reactive oxygen ...
Béchet Quentin - - 2014
While modeling algal productivity outdoors is crucial to assess the economic and environmental performance of full-scale cultivation, most of the models hitherto developed for this purpose have not been validated under fully relevant conditions, especially with regard to temperature variations. The objective of this study was to independently validate a ...
Lim Yi Chung YC Auckland Bioengineering Institute, University of Auckland, 70 Symonds St, Auckland, 1010, New - - 2014
In endothelial cells (ECs), the mechanotransduction of fluid shear stress is partially dependent on the transmission of force from the fluid into the cell (mechanotransmission). The role of the primary cilium in EC mechanotransmission is not yet known. To motivate a framework towards quantifying cilia contribution to EC mechanotransmission, we ...
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