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Barr John T JT Washington State University College of - - 2014
The mechanistic understanding of interactions between diet-derived substances and conventional medications in humans is nascent. Most investigations have examined cytochrome P450-mediated interactions. Interactions mediated by other phase I enzymes are understudied. Aldehyde oxidase (AO) is a phase I hydroxylase that is gaining recognition in drug design and development programs. Taken ...
Rittner Alexander A Institute for Organic Chemistry and Chemical Biology, Buchmann Institute for Molecular Life Sciences, Cluster of Excellence "Macromolecular Complexes", Goethe University Frankfurt, Max-von-Laue-Strasse 15, 60438 Frankfurt/Main - - 2014
Step-by-step to great diversity: With the potential to synthesize multi-millions of bioactive compounds, modular polyketide synthases (PKSs) are of great importance. In this Highlight, new developments in the understanding of the structure and function of these proteins are reviewed.
Huang Yen-Tsung YT Department of Epidemiology, Brown University, 121 S. Main St., Box G-S121-2, Providence, RI, 02912, - - 2014
Given the availability of genomic data, there have been emerging interests in integrating multi-platform data. Here, we propose to model genetics (single nucleotide polymorphism (SNP)), epigenetics (DNA methylation), and gene expression data as a biological process to delineate phenotypic traits under the framework of causal mediation modeling. We propose a ...
Montagnon Tamsyn T Department of Chemistry, University of Crete, 71003 Iraklion, Crete, Greece. - - 2014
The purpose of this article is to give a taste of just how powerful the union between furans and photochemically-generated singlet oxygen is proving to be as a synthetic tool and to suggest that this chemistry is only now really coming of age. In attempting to achieve this goal, its ...
Sizochenko Natalia N I. I. Mechnikov Odessa National University, Department of Chemistry, Dvoryanskaya str., 2, 65082, Odessa, - - 2014
Many metal oxide nanoparticles are able to cause persistent stress to live organisms, including humans, when discharged to the environment. To understand the mechanism of metal oxide nanoparticles' toxicity and reduce the number of experiments, the development of predictive toxicity models is important. In this study, performed on a series ...
Csambalik László L Divéky-Ertsey are with Faculty of Horticulture, Dept. of Ecological and Sustainable Production Systems, Corvinus Univ. Budapest, Villányi st. 29-43, 1118, Budapest, - - 2014
The aim of this study was to investigate 6 cherry tomato varieties in terms of morphological, instrumental, and sensory attributes. Hungarian cherry tomato landraces have not been investigated in comparison with new commercial varieties for these traits. Parameters investigated were water-soluble antioxidant capacity (FRAP, DPPH, and TEAC), and total polyphenol, ...
Ng Yan Cheng YC Department of Biomedical Engineering, National University of Singapore, - - 2014
Despite the significant roles of the cell-free layer (CFL) in balancing nitric oxide (NO) and oxygen (O2) bioavailability in arteriolar tissue, many previous numerical approaches have relied on a one-dimensional (1-D) steady-state model for simplicity. However, these models are unable to demonstrate the influence of spatiotemporal variations in the CFL ...
Kesheri Minu M Laboratory of Photobiology and Molecular Microbiology, Centre of Advanced Study in Botany, Banaras Hindu University, Varanasi, 221005, - - 2014
Cyanobacteria are known to endure various stress conditions due to the inbuilt potential for oxidative stress alleviation owing to the presence of an array of antioxidants. The present study shows that Antarctic cyanobacterium Nostoc commune possesses two antioxidative enzymes viz., superoxide dismutase (SOD) and catalase that jointly cope with environmental ...
Ho Shih-Hsin SH Organization of Advanced Science and Technology, Graduate School of Engineering, Kobe University, 1-1 Rokkodai, Nada-ku, Kobe 657-8501, - - 2014
Although the potential for biofuel production from microalgae via photosynthesis has been intensively investigated, information on the selection of a suitable operation strategy for microalgae-based biofuel production is lacking. Many published reports describe competitive strains and optimal culture conditions for use in biofuel production; however, the major impediment to further ...
da Silva Cinthia R U CR Faculdade de Engenharia Mecânica, Unicamp. Rua Mendeleyev 200, Cidade Universitária "Zeferino Vaz" , Campinas, SP, Brazil , - - 2014
This work assessed the environmental impacts of the production and use of 1 MJ of hydrous ethanol (E100) in Brazil in prospective scenarios (2020-2030), considering the deployment of technologies currently under development and better agricultural practices. The life cycle assessment technique was employed using the CML method for the life ...
Ni Bing-Jie BJ Advanced Water Management Centre, The University of Queensland, St. Lucia, Queensland 4072, Australia. Electronic address: - - 2014
Full-scale application of partial nitritation and anammox in a single floc-based sequencing batch reactor (SBR) has been achieved for high-rate nitrogen (N) removal, but mechanisms resulting in reliable operation are not well understood. In this work, a mathematical model was calibrated and validated to evaluate operating conditions that lead to ...
Minoarivelo H O HO H. O. Minoarivelo and K. Scheffler ( kscheffler@ucsd.edu ), Computer Science Division, Dept of Mathematical Sciences, Stellenbosch Univ., Matieland 7602, South Africa. - HOM and C. Hui, Centre for Invasion Biology, Dept of Mathematical Sciences, Stellenbosch Univ., Matieland 7602, South Africa. - KS and S. L. Kosakovsky Pond, Dept of Medicine, Univ. of California, San Diego, USA. - J. S. Terblanche, Centre for Invasion Biology, Dept of Conservation Ecology and Entomology, Stellenbosch Univ., Matieland 7602, South - - 2014
Ecological interaction networks, such as those describing the mutualistic interactions between plants and their pollinators or between plants and their frugivores, exhibit non-random structural properties that cannot be explained by simple models of network formation. One factor affecting the formation and eventual structure of such a network is its evolutionary ...
Djeradi Houria H Phytochemistry & Organic Synthesis Laboratory, University of Bechar, 08000, Bechar, Algeria, - - 2014
A QSAR model to predict the antioxidant activity of flavonoid compounds was developed. New electronic structure descriptors which are Fukui indices are correlated to the radical scavenging of flavonoids. These indices are obtained at DFT/B3LYP level of chemical quantum theory. The logIC50 experimental values of antioxidant activity are taken from ...
Snip L J P LJ Department of Chemical and Biochemical Engineering, Technical University of Denmark, Building 229, Søltofts Plads, 2800 Lyngby, Denmark E-mail: - - 2014
It is common practice in wastewater engineering to extend standard activated sludge models (ASMs) with extra process equations derived from batch experiments. However, such experiments have often been performed under conditions different from the ones normally found in wastewater treatment plants (WWTPs). As a consequence, these experiments might not be ...
Oquendo Maria A - - 2014
Suicide, a major cause of death worldwide, has distinct biological underpinnings. The authors review and synthesize the research literature on biomarkers of suicide, with the aim of using the findings of these studies to develop a coherent model for the biological diathesis for suicide. The authors examined studies covering a ...
Frajka-Williams E E University of Southampton, National Oceanography Centre, Southampton SO14 3ZH, UK - - 2014
Sustained observations of ocean properties reveal a global warming trend and rising sea levels. These changes have been documented by traditional ship-based measurements of ocean properties, whereas more recent Argo profiling floats and satellite records permit estimates of ocean changes on a near real-time basis. Through these and newer methods ...
Masoori Mohammad M Department of Chemical Engineering, University of Rhode Island, Kingston, Rhode Island 02881, - - 2014
Asphalt is an amorphous or semi-crystalline material whose mechanical performance relies on viscoelastic responses to applied strain or stress. Chemical composition and its effect on the viscoelastic properties of model asphalts have been investigated here by computing complex modulus from molecular dynamics simulation results for two different model asphalts whose ...
Spector June T JT 1.Departments of Environmental and Occupational Health Sciences and Medicine, University of Washington, Seattle, WA 98105, USA - - 2014
The potential consequences of occupational heat stress in a changing climate on workers, workplaces, and global economies are substantial. Occupational heat stress risk is projected to become particularly high in middle- and low-income tropical and subtropical regions, where optimal controls may not be readily available. This commentary presents occupational heat ...
Matchin William W Department of Cognitive Sciences, University of California, Irvine, United - - 2014
Accounts of the role of Broca's area in sentence comprehension range from specific syntactic operations to domain-general processes. The present study was designed to tease apart these two general accounts by measuring the BOLD response to two syntactically distinct long-distance dependencies that invoke abstractly similar predictive processes: backward anaphora and ...
Carabaño M J MJ Departamento de Mejora Genética Animal, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Madrid 28040, Spain. Electronic address: - - 2014
Data from milk recording of Holstein-Friesian cows together with weather information from 2 regions in Southern Spain were used to define the models that can better describe heat stress response for production traits and somatic cell score (SCS). Two sets of analyses were performed, one aimed at defining the population ...
Wang Liang L Mathematical Sciences Department, Worcester Polytechnic Institute, Worcester, MA, - - 2014
Atherosclerotic plaque progression is believed to be associated with mechanical stress conditions. Patient follow-up in vivo intravascular ultrasound coronary plaque data were acquired to construct fluid-structure interaction (FSI) models with cyclic bending to obtain flow wall shear stress (WSS), plaque wall stress (PWS) and strain (PWSn) data and investigate correlations ...
Simons Margaret N MN The Pennsylvania State - - 2014
Zea mays L. is an important C4 plant due to its widespread use as a cereal and energy crop. A second-generation genome-scale metabolic model for the maize leaf was created to capture C4 carbon fixation and investigate nitrogen (N) assimilation by modeling the interactions between the bundle sheath and mesophyll ...
Orzel Joanna J Institute of Chemistry, The University of Silesia, 9 Szkolna Street, 40-006 Katowice, - - 2014
Models to predict the total antioxidant capacity (TAC) of rooibos tea infusions from their chromatographic fingerprints and peak table data (content of individual phenolic compounds), obtained using HPLC with diode array detection, were developed in order to identify potential antioxidant markers. Peak table data included the content of 12 compounds, ...
Tripathi Vijay V Center of Bioinformatics, IIDS, Faculty of Science, University of Allahabad, Allahabad, - - 2014
Superoxide dismutases are a class of enzymes that catalyze the dismutation of superoxide into oxygen and hydrogen peroxide. As such, they are an important antioxidant defense in nearly all cells exposed to oxygen. Superoxide dismutase (SOD) acts as first line of defense against oxidative and genetic stress. Manganese superoxide dismutase ...
Rey Patrice F PF Earthbyte Research Group, School of Geosciences, The University of Sydney, Sydney NSW 2006, - - 2014
Stresses acting on cold, thick and negatively buoyant oceanic lithosphere are thought to be crucial to the initiation of subduction and the operation of plate tectonics, which characterizes the present-day geodynamics of the Earth. Because the Earth's interior was hotter in the Archaean eon, the oceanic crust may have been ...
Zhang Xinzhuang X State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Kanion Pharmaceutical Corporation, Lianyungang City 222002, P. R. China. - - 2014
In comparison to the current target-based screening approach, it is increasingly evident that active lead compounds based on disease-related phenotypes are more likely to be translated to clinical trials during drug development. That is, because human diseases are in essence the outcome of the abnormal function of multiple genes, especially ...
Wang Lingnan - - 2014
Dietary antioxidants as health promoters for human beings have attracted plentiful attentions and triggered tremendous efforts in evaluation of the antioxidant capacity. Unfortunately, no versatile detection system has been designed to date. Due to the possible synergistic effect among antioxidant components in a diversified system, to isolate and quantify individual ...
Bai Xuelian X Department of Soil Science, North Dakota State University, Fargo, ND 58108-6050, - - 2014
Animal manure is the primary source of exogenous free estrogens in the environment, which are known endocrine-disrupting chemicals to disorder the reproduction system of organisms. Conjugated estrogens can act as precursors to free estrogens, which may increase the total estrogenicity in the environment. In this study, a comprehensive model was ...
Steger Michael F MF Colorado State University; North-West University, Vanderbijlpark, South - - 2014
Posttrauma adjustment theories postulate that intense stressors violate people's beliefs about the world and perceived ability to achieve valued goals. Failure to make meaning from traumatic events exacerbates negative adjustment (e.g., PTSD), whereas success facilitates positive adjustment (e.g., stress-related growth). The current study aimed to test this model of direct ...
Roy Pierre-Olivier PO CIRAIG, Chemical Engineering Department, École Polytechnique de Montréal, P.O. Box 6079, Montréal, Québec, Canada, H3C 3A7. Electronic address: - - 2014
Characterization factors (CFs) are used in life cycle assessment (LCA) to quantify the potential impact per unit of emission. CFs are obtained from a characterization model which assess the environmental mechanisms along the cause-effect chain linking an emission to its potential damage on a given area of protection, such as ...
Santos-Filho Paulo César Freitas PC Department of Restorative Dentistry and Dental Materials, Dentistry School, Federal University of Uberlandia, Minas Gerais, Brazil. Electronic address: - - 2014
The aim of this study was to evaluate the influence of a ferrule, post system, and length on the stress distribution of weakened root-filled teeth. The investigation was conducted by using 3-dimensional (3D) finite element analysis. A sound tooth and 8 3D models of a weakened root-filled central incisor were ...
Patra P K PK 1] Department of Environmental Geochemical Cycle Research, JAMSTEC, Yokohama 236 0001, Japan [2] CAOS, Graduate School of Studies, Tohoku University, Sendai 980 8578, - - 2014
The hydroxyl radical (OH) is a key oxidant involved in the removal of air pollutants and greenhouse gases from the atmosphere. The ratio of Northern Hemispheric to Southern Hemispheric (NH/SH) OH concentration is important for our understanding of emission estimates of atmospheric species such as nitrogen oxides and methane. It ...
Kingsley Laura J LJ Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, Indiana, 47907, - - 2014
Predicting atoms in a potential drug compound that are susceptible to oxidation by cytochrome P450 (CYP) enzymes is of great interest to the pharmaceutical community. We aimed to develop a computational approach combining ligand- and structure-based design principles to accurately predict sites of metabolism (SoMs) in a series of CYP2C9 ...
Johnson Jessica K M JK Graduate School of Social Work, Boston College, Chestnut Hill, Massachusetts. - - 2014
Aging successfully entails good physical and cognitive health, as well as ongoing participation in social and productive activity. This study hones in on participation in productive activity, a factor that makes an important contribution to successful aging. One conceptual model of productive activity in later life specifies the antecedents and ...
Börlin Christoph S - - 2014
BackgroundAutophagy is a vesicle-mediated pathway for lysosomal degradation, essential under basal and stressed conditions. Various cellular components, including specific proteins, protein aggregates, organelles and intracellular pathogens, are targets for autophagic degradation. Thereby, autophagy controls numerous vital physiological and pathophysiological functions, including cell signaling, differentiation, turnover of cellular components and pathogen ...
Chen YungChung Y Minnesota Dental Research Center for Biomaterials and Biomechanics, School of Dentistry, University of Minnesota, MN, USA. Electronic address: - - 2014
This study aimed to investigate how the structural stress distribution in human teeth could be affected by the presence of a graded material distribution often found in nature using the finite element (FE) method. Hydroxyapatite (HA) tablets with different densities were scanned using a Micro-CT scanner to obtain a relationship ...
Ikegawa Yusuke Y Graduate School of Science, Osaka Prefecture University, Gakuen-cho 1-1, Naka-ku, Sakai, 599-8531 JAPAN. Electronic address: - - 2014
Intra-guild predation (IGP), predation on consumers which share common prey with the predators, is an important community module to understand a mechanism for persistence of complex food webs. However, classical theory suggests that persistence of an IGP system is unlikely particularly at high productivity, while empirical data do not support ...
Machado Daniel D Centre of Biological Engineering, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal. Electronic address: - - 2014
Curcumin is a natural compound obtained from turmeric, and is well known for its pharmacological effects. In this work, we design a heterologous pathway for industrial production of curcumin in Escherichia coli. A kinetic model of the pathway is then developed and connected to a kinetic model of the central ...
Fachet Melanie M Max Planck Institute for Dynamics of Complex Technical Systems, Process Systems Engineering, Sandtorstr. 1, 39106 Magdeburg, - - 2014
In this work, a photoautotrophic growth model incorporating light and nutrient effects on growth and pigmentation of Dunaliella salina was formulated. The model equations were taken from literature and modified according to the experimental setup with special emphasis on model reduction. The proposed model has been evaluated with experimental data ...
Rahman Tanzina T University of Texas at San Antonio, Department of Civil and Environmental Engineering, One UTSA Circle, San Antonio, TX 78249, - - 2014
Aluminum oxide nanoparticles have been widely used in various consumer products and there are growing concerns regarding their exposure in the environment. This study deals with the modeling, sensitivity analysis and uncertainty quantification of one-dimensional transport of nano-sized (~82nm) aluminum oxide particles in saturated sand. The transport of aluminum oxide ...
Kourdali Sidali S Department of Industrial Chemistry, Faculty of Technology, University of Saàd Dahlab at Blida, PO Box 270, 09000 Blida, Algeria; Laboratory of Natural Substances Chemistry and Biomolecules, University of Saàd Dahlab at Blida, PO Box 270, 09000 Blida, Algeria; National Centre for Research and Development of Fisheries and Aquaculture (CNRDPA) 11, Bd Amirouche PO Box 67, Bousmail (W. Tipaza), Algeria. Electronic address: - - 2014
The present study was undertaken to investigate the degradation and removal of direct yellow 9 (DY9) by the electro-Fenton (EF) process in batch reactor using iron and stainless steel electrodes. DY9 removal decreased with the increase in pH (3 to 8) and increased with the increase in current intensity (0.05 ...
Walter Johannes J Institute of Particle Technology (LFG), Friedrich-Alexander University Erlangen-Nürnberg (FAU), Cauerstr. 4, 91058, Erlangen, - - 2014
In this paper, a method to determine the lateral dimensions of 2D nanosheets directly in suspension by analytical ultracentrifugation (AUC) is shown. The basis for this study is a well-characterized and stable dispersion of graphene oxide (GO) monolayers in water. A methodology is developed to correlate the sedimentation coefficient distribution ...
Kroeger Timm T Central Science Department, Nature Conservancy, Arlington, VA 22203; - - 2014
High ambient ozone (O3) concentrations are a widespread and persistent problem globally. Although studies have documented the role of forests in removing O3 and one of its precursors, nitrogen dioxide (NO2), the cost effectiveness of using peri-urban reforestation for O3 abatement purposes has not been examined. We develop a methodology ...
Wu Li-Ping LP Associate Professor, Department of Orthopedics, Jiangmen Central Hospital of Guangdong Province China (Affiliated Jiangmen Hospital of Sun Yat-Sen University), 529031 Jiangmen, Guangdong, PR China. Electronic address: - - 2014
The objective of this study was to research the distribution of stresses and displacements in cervical nuclei pulposi during simulated cervical spine manipulation (CSM). A 3-dimensional finite element model of C3/4~C6/7 was established. The detailed mechanical parameters of CSM were analyzed and simulated. During the process, the changes in stresses ...
Coe Kirsten K KK Department of Ecology and Evolutionary Biology, Cornell University, Ithaca, NY, 14853, USA, - - 2014
Fluctuations in mean annual precipitation (MAP) will strongly influence the ecology of dryland ecosystems in the future, yet, because individual precipitation events drive growth and resource availability for many dryland organisms, changes in intra-annual precipitation may disproportionately influence future dryland processes. This work examines the hypothesis that intra-annual precipitation changes ...
Wang Yan Y College of Pharmacy, Yaoke University i.e. Shenyang Pharmaceutical University, Shenyang, P.R. China; College of Pharmacy and Chemistry, Dali University, Dali, P.R. - - 2014
A capillary electrophoresis fingerprint was constructed for Sanhuang Tablet of a Chinese traditional patent medicine that was commonly used in clinical practice, where the isosceles trapezoid method was first applied for the optimization of background electrolyte solution, and the resolution index was performed to assess the experimental conditions, furthermore, a ...
Sharma Mukesh C MC Drug Design and Development Laboratory, School of Pharmacy, Devi Ahilya Vishwavidyalaya, Takshila Campus, Khandwa Road, Indore, M.P, 452 001, India, - - 2014
A series of oxadiazole-substituted α-isopropoxy phenylpropanoic acids with dual activators of PPARα and PPARγ derivatives were subjected to two dimensional and k-nearest neighbour Molecular field analysis. The statistically significant best 2D-QSAR (PPARα) model having good predictive ability with statistical values of r(2) = 0.8725, q(2) = 0.7957 and pred_r(2) = ...
Sharma Mukesh C MC Drug Design and Development Laboratory, School of Pharmacy, Devi Ahilya University, Takshila Campus, Khandwa Road, Indore, 452 001, India, - - 2014
The present studies are an attempt in this direction seeking for the development and comparison of QSAR models of substituted 2-aminopyridines derivatives as inhibitors of nitric oxide synthases by different feature selection methods. Comparing the two different feature selection methods, it is implicit that the model built with the selected ...
Caron Troy T Wellspan Orthopedics, York, - - 2014
The decision to leave a job can be very stressful. Multiple variables must be considered before turning in your notice. The goal of this paper is to help you decide if changing jobs is a smart decision, and, if it is, when to do it.
Kocalevent Rüya-Daniela - - 2014
The population-based study examined postulated effects, derived from a resources-demands-model about gender-related aspects of self-efficacy, optimism, chronic stress, and exhaustion. Data acquisition was carried out by a market research institute with a multi-topic questionnaire in the general population (N = 2,552). Instruments administered were the Questionnaire for Self-Efficacy and Optimism, ...
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