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Ingle Atul A Department of Electrical and Computer Engineering, University of Wisconsin-Madison, Madison WI 53706, USA. ; Department of Medical Physics, University of Wisconsin-Madison, Madison WI 53705, - - 2015
This paper discusses the development of a slope estimation algorithm called MAPSlope for piecewise linear data that is corrupted by Gaussian noise. The number and locations of slope change points (also known as breakpoints) are assumed to be unknown a priori though it is assumed that the possible range of ...
Mwaffo Violet V Department of Mechanical and Aerospace Engineering, New York University Polytechnic School of Engineering, Brooklyn, NY, - - 2015
Zebrafish are gaining momentum as a laboratory animal species for the investigation of several functional and dysfunctional biological processes. Mathematical models of zebrafish behaviour are expected to considerably aid in the design of hypothesis-driven studies by enabling preliminary in silico tests that can be used to infer possible experimental outcomes ...
Wang Xiao-Feng XF Department of Quantitative Health Sciences / Biostatistics Section, Cleveland Clinic Lerner Research Institute, Cleveland, OH 44195, - - 2015
This paper is motivated by a wide range of background correction problems in gene array data analysis, where the raw gene expression intensities are measured with error. Estimating a conditional density function from the contaminated expression data is a key aspect of statistical inference and visualization in these studies. We ...
Vexler Albert A Department of Biostatistics, New York State University at Buffalo, 715 Kimball Tower, 3435 Main Street, Buffalo, NY, 14214, USA, - - 2015
The aim of this chapter is to review and examine different methods in order to display correct and efficient statistical techniques based on complete/incomplete data subject to different sorts of measurement error (ME) problems. Instrument inaccuracies, biological variations, and/or errors in questionnaire-based self-report data can lead to significant MEs in ...
Pekala Ronald J RJ a Coatesville Veterans Administration Medical Center , Pennsylvania , - - 2015
Abstract This study sought to replicate an earlier study wherein imagery vividness before and during a phenomenological hypnotic assessment procedure was assessed, while also measuring trance (hypnoidal) state effects and several other variables. Correlational and regression analyses for that study suggested that imagery vividness during hypnotism was predicted by combined ...
Hansen Thomas F TF Department of Biology, Centre for Ecological and Evolutionary Synthesis, University of Oslo, P.B. 1066, Blindern, Oslo, 0316, Norway, - - 2015
Measurement is the assignment of numbers to reality, and valid measurement requires that these numbers represent relevant aspects of reality. I discuss epistatic gene interactions from a measurement-theoretical perspective and argue that the standard measurements of epistasis in classical quantitative genetics have failed to capture aspects of epistasis that are ...
Wagner Günter P GP Department of Ecology and Evolutionary Biology, and Systems Biology Institute, Yale University, 840 West Campus Drive, West Haven, CT, 06516, USA, - - 2015
Traditionally statistical interactions and epistasis are defined with respect to the ANOVA model of additive effects; that is, epistasis is defined as a deviation from the additive mode of combining main effects of gene substitutions. Furthermore, the definition is relative to a particular scale and epistasis can potentially be eliminated ...
Liu Jie J Department of Computer Sciences, University of - - 2014
It has been shown that graphical models can be used to leverage the dependence in large-scale multiple testing problems with significantly improved performance (Sun & Cai, 2009; Liu et al., 2012). These graphical models are fully parametric and require that we know the parameterization of f 1 - the density ...
Amaratunga Dhammika D 1 Independent Consultant and Researcher , Bridgewater, New - - 2014
Abstract An important issue in classification is the assessment of sample similarity. This is nontrivial in high-dimensional or megavariate datasets-datasets that are comprised of simultaneous measurements on thousands of features, many of which carry little or no information regarding consistent sample differences. Conventional similarity measures do not work particularly well ...
Lim Changwon C Department of Applied Statistics, Chung-Ang University, Seoul, - - 2014
Nonlinear regression is often used to evaluate the toxicity of a chemical or a drug by fitting data from a dose-response study. Toxicologists and pharmacologists may draw a conclusion about whether a chemical is toxic by testing the significance of the estimated parameters. However, sometimes the null hypothesis cannot be ...
Fong Duncan K H DK Smeal College of Business, The Pennsylvania State University, University Park, PA, 16802 , - - 2014
A new Bayesian multinomial probit model is proposed for the analysis of panel choice data. Using a parameter expansion technique, we are able to devise a Markov Chain Monte Carlo algorithm to compute our Bayesian estimates efficiently. We also show that the proposed procedure enables the estimation of individual level ...
Fonseca Mj M EPIUnit - Institute of Public Health, University of Porto, Porto, Portugal; Department of Clinical Epidemiology, Predictive Medicine and Public Health, University of Porto Medical School, Porto, - - 2014
We aimed to apply a novel model to estimate weight change and its reference intervals during the first 96-hours-of-life and the time of weight nadir. This study involved 1,288 full-term singletons, from the Generation XXI birth cohort. Recruitment occurred between 2005 and 2006 in all five public units providing obstetrical ...
Tetko Igor V IV Helmholtz-Zentrum München - German Research Centre for Environmental Health (GmbH), Institute of Structural Biology , Munich 85764, - - 2014
This article contributes a highly accurate model for predicting the melting points (MPs) of medicinal chemistry compounds. The model was developed using the largest published data set, comprising more than 47k compounds. The distributions of MPs in drug-like and drug lead sets showed that >90% of molecules melt within [50,250]°C. ...
Kornreich Davida - - 2014
Objective :  Comparison of global versus landmark analyses of facial asymmetry using three-dimensional photogrammetry to establish a precise method for evaluating facial asymmetry. Design :  The landmark-based approach utilized anthropometric data points. Our global approach involved registration of mirror images, independent of a midplane, to calculate a root mean square ...
Montoye Alexander H K AH 1Human Performance Laboratory, Ball State University, Muncie, IN; 2Department of Kinesiology, Michigan State University, East Lansing, MI; 3Department of Electrical and Computer Engineering, Michigan State University, East Lansing, - - 2014
The purpose of this study was to develop, validate, and compare energy expenditure prediction models for accelerometers placed on the hip, thigh, and wrists using simple accelerometer features as input variables in energy expenditure prediction models. Forty four healthy adults participated in a 90-minute semi-structured, simulated free-living activity protocol. During ...
Anthoine Emmanuelle - - 2014
PurposeNew patient reported outcome (PRO) measures are regularly developed to assess various aspects of the patients¿ perspective on their disease and treatment. For these instruments to be useful in clinical research, they must undergo a proper psychometric validation, including demonstration of cross-sectional and longitudinal measurement properties. This quantitative evaluation requires ...
Veale D D The Institute of Psychiatry, King's College London and South London and Maudsley NHS Foundation - - 2014
To systematically review and create nomograms on flaccid and erect penile size measurements. Study key eligibility criteria: measurement of penis size by a health professional using a standard procedure; a minimum of 50 participants per sample Exclusion criteria were samples with a congenital or acquired penile abnormality. previous surgery, complaint ...
Gaspa G G 1Dipartimento di Agraria,Viale Italia 39,07100 - - 2014
In this study, the effects of breed composition and predictor dimensionality on the accuracy of direct genomic values (DGV) in a multiple breed (MB) cattle population were investigated. A total of 3559 bulls of three breeds were genotyped at 54 001 single nucleotide polymorphisms: 2093 Holstein (H), 749 Brown Swiss ...
Wu Hao H Free University of Berlin, Arnimallee 6, 14195 Berlin, - - 2014
We propose a discrete transition-based reweighting analysis method (dTRAM) for analyzing configuration-space-discretized simulation trajectories produced at different thermodynamic states (temperatures, Hamiltonians, etc.) dTRAM provides maximum-likelihood estimates of stationary quantities (probabilities, free energies, expectation values) at any thermodynamic state. In contrast to the weighted histogram analysis method (WHAM), dTRAM does not ...
Cros David D CIRAD, UMR AGAP (Genetic Improvement and Adaptation of Mediterranean and Tropical Plants Research Unit), 34398, Montpellier, France, - - 2014
Genomic selection empirically appeared valuable for reciprocal recurrent selection in oil palm as it could account for family effects and Mendelian sampling terms, despite small populations and low marker density. Genomic selection (GS) can increase the genetic gain in plants. In perennial crops, this is expected mainly through shortened breeding ...
Ghanbarnejad Fakhteh F Max Planck Institute for the Physics of Complex Systems, Dresden, Germany - - 2014
It is well accepted that adoption of innovations are described by S-curves (slow start, accelerating period and slow end). In this paper, we analyse how much information on the dynamics of innovation spreading can be obtained from a quantitative description of S-curves. We focus on the adoption of linguistic innovations ...
Gupta Ankit A Department of Biosystems Science and Engineering, ETH Zurich, Mattenstrasse 26, 4058 Basel, - - 2014
We consider the problem of estimating parameter sensitivity for Markovian models of reaction networks. Sensitivity values measure the responsiveness of an output with respect to the model parameters. They help in analysing the network, understanding its robustness properties and identifying the important reactions for a specific output. Sensitivity values are ...
Volz Erik M - - 2014
Many population genetic models have been developed for the purpose of inferring population size and growth rates from random samples of genetic data. We examine two popular approaches to this problem, the coalescent and the birth–death-sampling model (BDM), in the context of estimating population size and birth rates in a ...
Allison Mari A MA The Center for Injury Research and Prevention, The Children's Hospital of Philadelphia, 3535 Market St. Suite 1150, Philadelphia, PA, 19104, USA, - - 2014
Helmet-based instrumentation is used to study the biomechanics of concussion. The most extensively used systems estimate rotational acceleration from linear acceleration, but new instrumentation measures rotational velocity using gyroscopes, potentially reducing error. This study compared kinematics from an accelerometer and gyroscope-containing system to reference measures. A Hybrid III (HIII) adult ...
Guilleux Alice A Biostatistics, Pharmacoepidemiology and Subjective Measures in Health Sciences, EA 4275, University of Nantes, Nantes, - - 2014
Some IRT models have the advantage of being robust to missing data and thus can be used with complete data as well as different patterns of missing data (informative or not). The purpose of this paper was to develop an algorithm for response shift (RS) detection using IRT models allowing ...
Nagai Takashi T National Institute for Agro-Environmental Sciences, Tsukuba, Ibaraki, - - 2014
Although species sensitivity distribution (SSD) is a key concept for quantitative ecological risk assessment, its application is limited owing to a lack of sufficient data for the analysis, especially on the toxicity of herbicides for primary producers. The authors developed a method of herbicide SSD estimation using single-species toxicity data ...
Back Hyun-Moon HM College of Pharmacy, Chungnam National University , Daejeon , Korea - - 2014
Abstract 1. QT prolongation is one of the major safety tests used in the development of a new drug. The ICH guidelines for the evaluation of QT prolongation recommend the use of the in vitro hERG assay and the in vivo telemetry test. However, QT intervals change under normal conditions ...
Calcagni M C MC Division of Medical Physics, Università Cattolica del Sacro Cuore, Roma, Italy - - - 2014
To verify the feasibility, in clinical practice, of three simplified methods (Hunter, Sadato and another one proposed by our group) to calculate Ki and MRglu of 18F-FDG, comparing the results with those derived by the linear regression (LR) method (considered the golden standard), and also with SUV. Forty-five patients (32males, ...
Weiss Michael M Department of Pharmacology, Martin Luther University Halle-Wittenberg, Halle, Germany. Electronic address: - - 2014
The model of a proportional change in fractional dissolution rate was used to quantify influences on the vitro dissolution process. After fitting the original dissolution profile with an empirical model (inverse Gaussian distribution), acceleration and deceleration effects due to dissolution conditions or formulation parameters could be described by one parameter ...
Gillings Simon S British Trust for Ornithology, The Nunnery, Thetford, Norfolk, IP24 2PU, - - 2014
There is good evidence that species' distributions are shifting poleward in response to climate change, and wide interest in the magnitude of such responses for scientific and conservation purposes. It has been suggested from the directions of climatic changes that species' distribution shifts may not be simply poleward, but this ...
Li Ruimin R Department of Civil and Environmental Engineering, Massachusetts Institute of Technology (MIT), 77 Massachusetts Avenue, Cambridge, MA 0219, USA; Department of Civil Engineering, Tsinghua University, Beijing, 100084, China. Electronic address: - - 2014
Traffic incident duration is known to result from a combination of multiple factors, including covariates such as spatial and temporal characteristics, traffic conditions, and existence of secondary accidents but also the clearance method itself. In this paper, a competing risks mixture model is used to investigate the influence of clearance ...
Robinson John D - - 2014
BackgroundThe allele frequency spectrum (AFS) consists of counts of the number of single nucleotide polymorphism (SNP) loci with derived variants present at each given frequency in a sample. Multiple approaches have recently been developed for parameter estimation and calculation of model likelihoods based on the joint AFS from two or ...
Spiess Andrej-Nikolai AN University Medical Center Hamburg-Eppendorf, Hamburg, - - 2014
Quantification cycle (Cq) and amplification efficiency (AE) are parameters mathematically extracted from raw data to characterize quantitative PCR (qPCR) reactions and quantify the copy number in a sample. Little attention has been paid to the effects of preprocessing and the use of smoothing or filtering approaches to compensate for noisy ...
Brautigam Chad A CA Department of Biophysics, The University of Texas Southwestern Medical Center, Dallas, TX, 75390-8816. Electronic address: - - 2014
As isothermal titration calorimetry (ITC) gains popularity for the characterization of enthalpies and equilibrium association constants of simple 1:1 biomolecular interactions, its use for more complex systems is growing. The method is increasingly used to study interactions in which a single binding partner (molecule "A") interacts with multiple copies of ...
Liao Chao C College of Food Science and Technology, Shanghai Ocean University, No. 999 Hu Cheng Huan Road, Shanghai, 201306, - - 2014
The aim of this study is to simultaneously construct PCR-DGGE-based predictive models of Listeria monocytogenes and Vibrio parahaemolyticus on cooked shrimps at 4(°) C and 10(°) C. Calibration curves were established to correlate peak density of DGGE bands with microbial counts. Microbial counts derived from PCR-DGGE and plate methods were ...
Cho Won-Sang WS Department of Neurosurgery, Kangwon National University School of Medicine, Kangwon National University Hospital, Chuncheon-si, Gangwon-do, Republic of - - 2014
Exact measurements of cerebral aneurysms are important in terms of their treatment. However, there is no definitive way to estimate the exact volume of an aneurysm. Our aim was to compare aneurysm volume measured under different conditions: threshold values, observers, and measurement methods. 40 aneurysms and 7 phantom models were ...
Grice James W JW 1 Department of Psychology Oklahoma State University at - - 2014
Summary.-Social scientists are often interested in computing the proportion of overlap and nonoverlap between two normal distributions that are separated by some magnitude. In his popular book, Statistical Power Analysis for the Behavioral Sciences (1988, 2nd ed.), Jacob Cohen provided a table (Table 2.2.1) for determining such proportions from common ...
Hagen David R DR Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA. - - 2014
A major effort in systems biology is the development of mathematical models that describe complex biological systems at multiple scales and levels of abstraction. Determining the topology-the set of interactions-of a biological system from observations of the system's behavior is an important and difficult problem. Here we present and demonstrate ...
Kandris K K School of Civil Engineering, National Technical University of Athens, Iroon Polytechniou 9, Zografou, 157 80, Athens, Greece, - - 2014
This work puts forth a heuristic approach for investigating compromises between quality of fit and parameter reliability for the Monod-type kinetics employed to model microbial reductive dechlorination of trichloroethene. The methodology is demonstrated with three models of increasing fidelity and complexity. Model parameters were estimated with a stochastic global optimization ...
Maltarollo Vinícius Gonçalves VG Federal University of ABC (UFABC), Centre for Natural Sciences and Humanities , Santa Adélia Street, 166, Bangu, Santo André -SP , - - 2014
Introduction: Pharmacokinetics involves the study of absorption, distribution, metabolism, excretion and toxicity of xenobiotics (ADME-Tox). In this sense, the ADME-Tox profile of a bioactive compound can impact its efficacy and safety. Moreover, efficacy and safety were considered some of the major causes of clinical failures in the development of new ...
Tsamandouras Nikolaos N Centre for Applied Pharmacokinetic Research, Manchester Pharmacy School, The University of Manchester, Stopford Building, Room 3.32, Oxford Road, Manchester, M13 9PT, UK, - - 2014
To develop a population physiologically-based pharmacokinetic (PBPK) model for simvastatin (SV) and its active metabolite, simvastatin acid (SVA), that allows extrapolation and prediction of their concentration profiles in liver (efficacy) and muscle (toxicity). SV/SVA plasma concentrations (34 healthy volunteers) were simultaneously analysed with NONMEM 7.2. The implemented mechanistic model has ...
Pappas Panagiotis P a Department of Physical Education and Sport Science , National and Kapodistrian University of Athens , Athens , - - 2014
The aim of this study was to determine the intra-participant variabilities (i.e. intra-day and inter-day reliabilities) in leg and vertical stiffness, as well as related kinematic parameters, during treadmill running using the sine-wave method. Twenty-two healthy men ran on a treadmill at 4.44 m/s, and the flight and contact times were ...
Kasabova Boryana E BE Department of Anthropology, Tulane University, New Orleans, LA, - - 2014
A new model for estimating human body surface area and body volume/mass from standard skeletal metrics is presented. This model is then tested against both 1) "independently estimated" body surface areas and "independently estimated" body volume/mass (both derived from anthropometric data) and 2) the cylindrical model of Ruff. The model ...
Chi Eric C EC Department of Electrical and Computer Engineering, Rice University, Texas, - - 2014
Estimation of a covariance matrix or its inverse plays a central role in many statistical methods. For these methods to work reliably, estimated matrices must not only be invertible but also well-conditioned. The current paper introduces a novel prior to ensure a well-conditioned maximum a posteriori (MAP) covariance estimate. The ...
Solberg Svein S Norwegian Forest and Landscape Institute, P.O. Box 115, 1431 Ås, - - 2014
There is a need for new satellite remote sensing methods for monitoring tropical forest carbon stocks. Advanced RADAR instruments on board satellites can contribute with novel methods. RADARs can see through clouds, and furthermore, by applying stereo RADAR imaging we can measure forest height and its changes. Such height changes ...
Zhang Yajun - - 2014
In this paper, the challenging issue of estimating virtual unmodeled dynamics is addressed. A novel estimation algorithm based on historical data and the output of low-order approximation models for virtual un-modeled dynamics is presented. In particular, the virtual un-modeled dynamics are decomposed into known and unknown parts, where only the ...
Cheng Yu-Huei YH Department of Digital Content Design and Management, Toko University, Chiayi, Taiwan. - - 2014
Specific primers play an important role in polymerase chain reaction (PCR) experiments, and therefore it is essential to find specific primers of outstanding quality. Unfortunately, many PCR constraints must be simultaneously inspected which makes specific primer selection difficult and time-consuming. This paper introduces a novel computational intelligence-based method, Teaching-Learning-Based Optimisation, ...
Lemieux Genevieve G Postgraduate student, Orthodontic Graduate Program, University of Alberta, Edmonton, Alberta, Canada. Electronic address: - - 2014
Two-dimensional maxillary superimposition techniques have been routinely used in clinical practice, but a 3-dimensional plane has yet to be introduced and validated. The purposes of this study were to propose a new plane for regional superimposition of the maxillary complex and then to validate it through clinical data. Pretreatment and ...
Padilla Lace M - - 2014
Understanding how people interpret and use visually presented uncertainty data is an important yet seldom studied aspect of data visualization applications. Current approaches in visualization often display uncertainty as an additional data attribute without a well-defined context. Our goal was to test whether different graphical displays (glyphs) would influence a ...
Taghavi Moghaddam Pooria P Department of Pharmaceutics, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, - - 2014
Purpose: The aim of this study was to select the best calibration model for determination of propofol plasma concentration by high-performance liquid chromatography method. Methods: Determination of propofol in plasma after deproteinization with acetonitrile containing thymol (as internal standard) was carried out on a C18 column with a mixture of ...
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