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Wang Xiao-Feng XF Department of Quantitative Health Sciences / Biostatistics Section, Cleveland Clinic Lerner Research Institute, Cleveland, OH 44195, - - 2015
This paper is motivated by a wide range of background correction problems in gene array data analysis, where the raw gene expression intensities are measured with error. Estimating a conditional density function from the contaminated expression data is a key aspect of statistical inference and visualization in these studies. We ...
Vexler Albert A Department of Biostatistics, New York State University at Buffalo, 715 Kimball Tower, 3435 Main Street, Buffalo, NY, 14214, USA, - - 2015
The aim of this chapter is to review and examine different methods in order to display correct and efficient statistical techniques based on complete/incomplete data subject to different sorts of measurement error (ME) problems. Instrument inaccuracies, biological variations, and/or errors in questionnaire-based self-report data can lead to significant MEs in ...
Liu Jie J Department of Computer Sciences, University of - - 2014
It has been shown that graphical models can be used to leverage the dependence in large-scale multiple testing problems with significantly improved performance (Sun & Cai, 2009; Liu et al., 2012). These graphical models are fully parametric and require that we know the parameterization of f 1 - the density ...
Chi Eric C EC Department of Electrical and Computer Engineering, Rice University, Texas, - - 2014
Estimation of a covariance matrix or its inverse plays a central role in many statistical methods. For these methods to work reliably, estimated matrices must not only be invertible but also well-conditioned. The current paper introduces a novel prior to ensure a well-conditioned maximum a posteriori (MAP) covariance estimate. The ...
Solberg Svein S Norwegian Forest and Landscape Institute, P.O. Box 115, 1431 Ås, - - 2014
There is a need for new satellite remote sensing methods for monitoring tropical forest carbon stocks. Advanced RADAR instruments on board satellites can contribute with novel methods. RADARs can see through clouds, and furthermore, by applying stereo RADAR imaging we can measure forest height and its changes. Such height changes ...
Beck Robin M D RM School of Biological, Earth and Environmental Sciences, University of New South Wales, Sydney, New South Wales 2052, Australia - - 2014
Analyses of a comprehensive morphological character matrix of mammals using 'relaxed' clock models (which simultaneously estimate topology, divergence dates and evolutionary rates), either alone or in combination with an 8.5 kb nuclear sequence dataset, retrieve implausibly ancient, Late Jurassic-Early Cretaceous estimates for the initial diversification of Placentalia (crown-group Eutheria). These ...
Gemayel Nader N JPMorgan Chase, Columbus, OH, - - 2014
Ranked set sampling (RSS) is a data collection technique that combines measurement with judgment ranking for statistical inference. This paper lays out a formal and natural Bayesian framework for RSS that is analogous to its frequentist justification, and that does not require the assumption of perfect ranking or use of ...
ElMoaqet Hisham H Mechanical Engineering Department, University of Michigan, Ann Arbor, MI, 48109, USA, - - 2014
Episodic postoperative desaturation occurs predominantly from respiratory depression or airway obstruction. Monitor display of desaturation is typically delayed by over 30 s after these dynamic inciting events, due to perfusion delays, signal capture and averaging. Prediction of imminent critical desaturation could aid development of dynamic high-fidelity response systems that reduce or ...
Park Byoung-Keon BK a Biosciences Group , University of Michigan Transportation Research Institute , Ann Arbor , MI , - - 2014
We present a new method for rapidly measuring child body shapes from noisy, incomplete data captured from low-cost depth cameras. This method fits the data using a statistical body shape model (SBSM) to find a complete avatar in the realistic body shape space. The method also predicts a set of ...
Young Alexander I AI University of Oxford; - - 2014
Genetic association studies have explained only a small proportion of the estimated heritability of complex traits, leaving the remaining heritability 'missing'. Genetic interactions have been proposed as an explanation for this, because they lead to overestimates of the heritability and are hard to detect. Whether this explanation is true depends ...
Leffondre Karen K University of Bordeaux, ISPED, Centre INSERM U897-Epidemiology-Biostatistics, Bordeaux, - - 2014
The most commonly used methods to investigate risk factors associated with renal function trajectory over time include linear regression on individual glomerular filtration rate (GFR) slopes, linear mixed models and generalized estimating equations (GEEs). The objective of this study was to explain the principles of these three methods and to ...
Ragab Marwa A A MA Faculty of Pharmacy, Department of Pharmaceutical Analytical Chemistry, University of Alexandria, El-Messalah, Alexandria, 21521, Egypt, - - 2014
A spectrofluorimetric method was used for the estimation of closely related fluorescent reaction products, Fluoxetine and Olanzapine, in their mixture after derivatization of both drugs using 4-chloro-7- nitrobenzo - 2 -oxa-1,3 - diazole (NBD-Cl) in borate buffered medium (pH 9.5) to form highly fluorescent products. The method based on the ...
Lin Hung-Mo HM a Hung-Mo Lin, Department of Health Evidence and Policy , Mount Sinai School of Mledicine , One Gustave L. Levy Place, Box 1077, New York , NY 10029 , U.S.A - - 2014
ABSTRACT Some studies are designed to assess the agreement between different raters and/or different instruments in the medical sciences and pharmaceutical research. In practice, the same sample will be used to compare the agreement of two or more assessment methods for simplicity and to take advantage of the positive correlation ...
Lehman Paul A PA QPS, LLC, Delaware Technology Park, Newark, Delaware, - - 2014
Historically, percutaneous absorption permeation parameters have been derived from in vitro infinite dose studies, yet there is uncertainty in their accuracy if the applied vehicle saturates or damages the stratum corneum, or when the permeation parameters are inappropriately derived from cumulative absorption data. An approach is provided for determining penetration ...
Willemsen A Marcel AM Bioinformatics Laboratory, Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academical Medical Centre, Amsterdam, The - - 2014
Understanding cellular adaptation to environmental changes is one of the major challenges in systems biology. To understand how cellular systems react towards perturbations of their steady state, the metabolic dynamics have to be described. Dynamic properties can be studied with kinetic models but development of such models is hampered by ...
Ping Qingyun - - 2014
Microbial desalination cells (MDCs) are an emerging concept for simultaneous wastewater treatment and water desalination. This work presents a mathematical model to simulate dynamic behavior of MDCs for the first time through evaluating multiple factors such as organic supply, salt loading and current generation. Ordinary differential equations were applied to ...
Letchford Robert R School of Healthcare Sciences, Cardiff University, Second Floor, Cardigan House, Heath Park Campus, Cardiff, CF14 4XN, UK, - - 2014
Single leg hop for distance is used to inform rehabilitation and return to sport following anterior cruciate ligament reconstruction. However, impairment of landing mechanics may persist after the recommended performance parameter (hop distance) has been met; therefore, alternative methods are required. This study follows the COSMIN guideline to investigate the ...
Liu Tianfei - - 2014
BackgroundGrowth and carcass traits are very important traits for broiler chickens. However, carcass traits can only be measured postmortem. Genomic selection may be a powerful tool for such traits because of its accurate prediction of breeding values of animals without own phenotypic information. This study investigated the efficiency of genomic ...
Kehimkar Benjamin B Department of Chemistry, University of Washington, Box 351700, Seattle, WA, 98195, - - 2014
Recent efforts in predicting rocket propulsion (RP-1) fuel performance through modeling put greater emphasis on obtaining detailed and accurate fuel properties, as well as elucidating the relationships between fuel compositions and their properties. Herein, we study multidimensional chromatographic data obtained by comprehensive two-dimensional gas chromatography combined with time-of-flight mass spectrometry ...
Alvarsson Jonathan - - 2014
QSAR modeling using molecular signatures and support vector machines with a radial basis function is increasingly used for virtual screening in the drug discovery field. This method has three free parameters: C, γ and signature height. C is a penalty parameter which limits over-fitting, γ controls the width of the ...
Jawień Wojciech W Faculty of Pharmacy, Jagiellonian University in Kraków, ul. Medyczna 9, 30-688, Kraków, Poland, - - 2014
An effective method of construction of a linear estimator of AUC in the finite interval, optimal in the minimax sense, is developed and demonstrated for five PK models. The models may be given as an explicit C(t) relationship or defined by differential equations. For high variability and rich sampling the ...
Toseland Andrew - - 2014
Metatranscriptome sequence data can contain highly redundant sequences from diverse populations of microbes and so data reduction techniques are often applied before taxonomic and functional annotation. For metagenomic data, it has been observed that the variable coverage and presence of closely related organisms can lead to fragmented assemblies containing chimeric ...
Klumpp John J Environmental and Radiological Health Sciences, Colorado State University, 1618 Campus Delivery, Fort Collins, CO 80523, USA - - 2014
A 'moving-target' method for characterising background in a counting measurement in which the instantaneous background count rate is a function of time, rather than being fixed, is proposed. This model treats the average Poisson mean in observation period P as coming from a gamma distribution with parameters αP and βP. ...
Brisman Jonas J Occupational and Environmental Medicine, Sahlgrenska University Hospital, Gothenburg, - - 2014
A spirometric reference equation consists of a mathematical model with constants and coefficients optimized to fit a specific data set from healthy individuals. Commonly applied models are selected on statistical rather than physiological considerations. A predetermined model with constants and coefficients optimized to various populations would enable interpretable and interesting ...
Dennis Emily B EB School of Mathematics, Statistics and Actuarial Science, University of Kent, Canterbury, Kent CT2 7NF, - - 2014
The N-mixture model is widely used to estimate the abundance of a population in the presence of unknown detection probability from only a set of counts subject to spatial and temporal replication (Royle, 2004, Biometrics 60, 105-115). We explain and exploit the equivalence of N-mixture and multivariate Poisson and negative-binomial ...
Grabowski Tomasz T Polpharma Biologics, Trzy Lipy 3, 80-172, Gdańsk, Poland, - - 2014
This study attempted to determine the area under the curve ([Formula: see text]), which corresponds to the sum of all elimination processes correlated with the total clearance value. The study attempted to determine the [Formula: see text] based on the coordinates known from classic non-compartmental pharmacokinetics for a single administration ...
Bilge Ayse Humeyra AH Department of Industrial Engineering, Faculty of Engineering and Natural Sciences, Kadir Has University, Istanbul, Turkey, - - 2014
The susceptible-infected-removed (SIR) and the susceptible-exposed-infected-removed (SEIR) epidemic models with constant parameters are adequate for describing the time evolution of seasonal diseases for which available data usually consist of fatality reports. The problems associated with the determination of system parameters starts with the inference of the number of removed individuals ...
Xu Xinghua X From the Department of Neurosurgery, Chinese PLA General Hospital, Beijing, - - 2014
The Tada (ABC/2) formula has been used widely for volume assessment of intracerebral hematoma. However, the formula is crude for irregularly shaped hematoma. We aimed to compare the accuracy of the ABC/2 formula with open source software Slicer. Computed tomographic images of 294 patients with spontaneous intracerebral hematoma were collected. ...
Faller James E JE JILA, University of Colorado and National Institute of Standards and Technology, Boulder, CO 80309, USA Institute for Gravitational Research, School of Physics and Astronomy, University of Glasgow, Glasgow G12 8QQ, UK - - 2014
Determinations of the Newtonian constant of gravitation (big G) fit into the oftentimes-unappreciated area of physics called precision measurement-an area which includes precision measurements, null experiments and determinations of the fundamental constants. The determination of big G-a measurement which on the surface appears deceptively simple-continues to be one of Nature's ...
Wood Barry M BM National Research Council of Canada, 1200 Montreal Road, Ottawa, Ontario, ON K1A 0R6 Canada - - 2014
The primary objective of the CODATA Task Group on Fundamental Constants is 'to periodically provide the scientific and technological communities with a self-consistent set of internationally recommended values of the basic constants and conversion factors of physics and chemistry based on all of the relevant data available at a given ...
Santa-Ana-Tellez Yared Y WHO Collaborating Centre for Pharmaceutical Policy & Regulation, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht, the - - 2014
During 2010, Mexico and Brazil implemented policies to enforce existing laws of restricting over-the-counter sales of antibiotics. We determined if the enforcement led to more appropriate use by measuring changes in seasonal variation of penicillin use. We used retail quarterly sales data in defined-daily-dose per 1000 inhabitants-day (DDD/TID) from IMS ...
Steven Ernest C C 2nd Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden, - - 2014
D-optimal designs for discrete-type responses have been derived using generalized linear mixed models, simulation based methods and analytical approximations for computing the fisher information matrix (FIM) of non-linear mixed effect models with homogeneous probabilities over time. In this work, D-optimal designs using an analytical approximation of the FIM for a ...
Jamilis Martín M Group of Control Applications, LEICI, Faculty of Engineering, La Plata National University, CONICET, C.C.91 (1900), La Plata, Argentina, - - 2014
This paper focuses on the specific growth rate estimation problem in a Polyhydroxybutyrate bioplastic production process by industrial fermentation. The kinetics of the process are unknown and there are uncertainties in the model parameters and inputs. During the first hours of the growth phase of the process, biomass concentration can ...
Iannotti Giannina R GR Functional Brain Mapping Laboratory, Department of Fundamental Neurosciences, Geneva University Hospital, 1211, Geneva 14, - - 2014
One of the major artifact corrupting electroencephalogram (EEG) acquired during functional magnetic resonance imaging (fMRI) is the pulse artifact (PA). It is mainly due to the motion of the head and attached electrodes and wires in the magnetic field occurring after each heartbeat. In this study we propose a novel ...
El-Kilany Yeldez Y Chemistry Department, Faculty of Applied Science, Umm Al-Qura University, Mekkah, Kingdom of Saudi - - 2014
Ethyl (benzimidazol-1-yl)acetate was subjected to hydrazinolysis with hydrazine hydrate to give (benzimidazol-1-yl)acetohydrazide. The latter was reacted with various aromatic aldehydes to give the respective arylidene (1H-benzimidazol-1-yl)acetohydrazones. Solutions of the prepared hydrazones were found to contain two geometric isomers. Similarly (2-methyl-benzimidazol-1-yl)acetohydrazide was reacted with various aldehydes to give the corresponding hydrazones. ...
Dimzon Ian Ken IK Hochschule Fresenius, Institute for Analytical Research, Limburger St. 2, 65510 - - 2014
The determination of the degree of deacetylation of highly deacetylated chitosan by infrared (IR) spectroscopy was significantly improved with the use of partial least squares (PLS). The IR spectral region from 1500 to 1800cm(-1) was taken as the dataset. Different PLS models resulting from various data pre-treatments were evaluated and ...
Xie Feifan F School of Pharmaceutical Sciences, Central South University, Changsha 410013, PR - - 2014
The present study examined the agreement between in vitro dissolution f2 similarity and in vivo bioequivalence criteria for BCS class II drugs. Dissolution test profiles were generated using the First-order model with varied dissolution parameters around the standard values of a reference profile. The in vivo curves were derived from ...
Chevin Luis-Miguel LM CEFE-CNRS, UMR 5175, 34293, Montpellier, France. - - 2014
Temporal variation in phenotypic selection is often attributed to environmental change causing movements of the adaptive surface relating traits to fitness, but this connection is rarely established empirically. Fluctuating phenotypic selection can be measured by the variance and autocorrelation of directional selection gradients through time. However, the dynamics of these ...
Kropat Georg G Institute of Radiation Physics, Lausanne University Hospital, Rue du Grand-Pré 1, 1007 Lausanne, Switzerland. Electronic address: - - 2014
The aim of this study was to develop models based on kernel regression and probability estimation in order to predict and map IRC in Switzerland by taking into account all of the following: architectural factors, spatial relationships between the measurements, as well as geological information. We looked at about 240000 ...
Boily Michaël M Scientific and Regulatory Affairs, Algorithme Pharma Inc., 575 Armand-Frappier Blvd., Laval, QC, Canada H7V 4B3; Département de Pharmacologie, Faculté de Médecine, Université de Montréal, 2900 Édouard-Montpetit Blvd., Montreal, QC, Canada. Electronic address: - - 2014
To demonstrate bioequivalence (BE) between two prolonged-release (PR) drug formulations, single dose studies under fasting and fed state as well as at least one steady-state study are currently required by the European Medicines Agency (EMA). Recently, however, there have been debates regarding the relevance of steady state studies. New requirements ...
Lee Sukmock - - 2014
Smartphone camera lenses have become prevalent. Photographs, and video, taken by such lenses have many useful applications which depend on accurately knowing the distortion properties of the lens. In this paper, we present an accurate method to determine smartphone camera lens distortion to an estimated average error of 0.09%. We ...
Sande J A JA Department of Radiology, Aga Khan University Hospital, Nairobi, - - 2014
Assess the intraobserver and interobserver reproducibility of measurement of amniotic fluid index (AFI) and single deepest vertical pool (SDVP), also known as the maximal vertical pocket (MVP) METHODS: 175 fetuses were evaluated. For each fetus, two observers acquired duplicate sets of AFI and SDVP. Measurement differences were expressed as actual ...
Mu Fang F College of Agronomy & Plant Protection, Qingdao Agricultural University, Key Lab of Integrated Crop Pest Management of Shandong Province Qingdao 266109, - - 2014
All previously and currently used methods for effectiveness evaluation of control measures for the Diamondback Moth (DBM) do not simultaneously take the actual damage and population size into consideration. Here, we propose a new method, the Cumulative Damage Index Method, in which the number of larvae and their amount of ...
Choai Yuki Y Department of Statistical Science, The Graduate University for Advanced Studies, 10-3 Midori-cho, Tachikawa, Tokyo 190-8562, - - 2014
Recent advances in genomics and biotechnologies have accelerated the development of molecularly targeted treatments and accompanying markers to predict treatment responsiveness. However, it is common at the initiation of a definitive phase III clinical trial that there is no compelling biological basis or early trial data for a candidate marker ...
Cho Gene Young GY Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, New York, USA; Sackler Institute of Graduate Biomedical Sciences, New York University School of Medicine, New York, New York, - - 2014
To compare fitting methods and sampling strategies, including the implementation of an optimized b-value selection for improved estimation of intravoxel incoherent motion (IVIM) parameters in breast cancer. Fourteen patients (age, 48.4 ± 14.27 years) with cancerous lesions underwent 3 Tesla breast MRI examination for a HIPAA-compliant, institutional review board approved diffusion MR ...
Lee David V DV *School of Life Sciences, University of Nevada Las Vegas, Las Vegas, NV 89154, USA; Concord Field Station, Harvard University, Bedford, MA 01730, USA; Department of Biological Sciences, University of Idaho, Moscow, ID 83844, USA - - 2014
Trotting, bipedal running, and especially hopping have long been considered the principal bouncing gaits of legged animals. We use the radial-leg spring constant [Formula: see text] to quantify the stiffness of the physical leg during bouncing gaits. The radial-leg is modeled as an extensible strut between the hip and the ...
Lavini Cristina C Department of Radiology, Academic Medical Center, University of Amsterdam, 1100-DE Amsterdam, The Netherlands. Electronic address: - - 2014
Pharmacokinetic modelling in Dynamic Contrast Enhanced (DCE)-MRI is an elegant and useful method that provides valuable insight into angiogenesis in cancer and inflammatory diseases. Despite its widespread use, the reliability of the model results is still questioned, as many factors hamper the calculation of the model's parameters, resulting in the ...
Davids Mathias - - 2014
Many applications in MRI such as accelerated receive and transmit sequences require the synthesis of nonuniform three-dimensional gradient trajectories. Several methods have been proposed to design these gradient trajectories in a timeoptimal manner, subject to hardware specific gradient magnitude and slew rate constraints. In this work a novel method is ...
Jiang Xiaoqi X Division of Biostatistics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany, - - 2014
In most dose-response studies, repeated experiments are conducted to determine the EC50 value for a chemical, requiring averaging EC50 estimates from a series of experiments. Two statistical strategies, the mixed-effect modeling and the meta-analysis approach, can be applied to estimate average behavior of EC50 values over all experiments by considering ...
Snyder Matt M CooperRiis Healing Farm, Mill Spring, NC, 28756, USA, - - 2014
This is a 10 year longitudinal study of recovery progress within a residential program based upon therapeutic community principles and a Seven Domains Enhanced Recovery Model (Young and Ensing, 1999). A broad suite of measures associated with one of three definitions of recovery (symptom, function, and personal focused recovery) were administered ...
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