Search Results
Results 1 - 50 of 5993
1 2 3 4 5 6 7 8 9 10 >
Su Pei-Fang PF Department of Statistics, National Cheng Kung University, Tainan 70101, - - 2014
Sample size determination is essential to planning clinical trials. Jung (2008) established a sample size calculation formula for paired right-censored data based on the logrank test, which has been well-studied for comparing independent survival outcomes. An alternative to rank-based methods for independent right-censored data, advocated by Pepe and Fleming (1989), ...
Li Chunsheng C *Radiation Protection Bureau, Health Canada, 775 Brookfield Rd, Ottawa, Canada K1A - - 2014
Following a large-scale radiation emergency, affected populations will need to be screened soon after for potential contamination (external or internal). Effective management of the available resources can help maximize the screening throughputs. This paper reports the modeling results for screening throughputs in a population screening center using a set resource, ...
Cooper Chris C PenTAG, University of Exeter Medical School, University of Exeter, Veysey Building, Salmon Pool Lane, Exeter, EX2 4SG, UK. Electronic address: - - 2014
This article discusses how hard-to-reach population groups were conceptualized into a search filter. The objectives of this article were to (1) discuss how the authors designed a multistranded population search filter and (2) retrospectively test the effectiveness of the search filter in capturing all relevant populations (eg, homeless people, immigrants, ...
Falasinnu Titilola T From the *The School of Population and Public Health, University of British Columbia, Vancouver, Canada; †The Department of Statistics, University of British Columbia, Vancouver, Canada; and ‡British Columbia Centre for Disease Control, Vancouver, - - 2014
Prediction rules have been proposed as alternatives to screening recommendations and have potential applications in sexual health decision making. To our knowledge, there has been no review undertaken providing a critical appraisal of existing prediction rules in sexual health contexts. This review aims to identify and characterize prediction rules developed ...
Grimston Malcolm M Imperial College Centre for Energy Policy and Technology, 14 Princes Gardens, London SW7 2AZ, - - 2014
Choosing a suitable site for a nuclear power station requires the consideration and balancing of several factors. Some 'physical' site characteristics, such as the local climate and the potential for seismic activity, will be generic to all reactors designs, while others, such as the availability of cooling water, the area ...
Peng Wenjing - - 2014
Iturin A is a potential lipopeptide antibiotic produced by Bacillus subtilis. Optimization of iturin A yield by adding various concentrations of asparagine (Asn), glutamic acid (Glu) and proline (Pro) during the fed-batch fermentation process was studied using an artificial neural network-genetic algorithm (ANN-GA) and uniform design (UD). Here, ANN-GA based ...
Galantucci Luigi Maria LM Laboratorio di Prototipazione Rapida e Reverse Engineering, Dipartimento di Meccanica Matematica e Management, Politecnico di Bari, viale Japigia 182, 70126, Bari, Italy, - - 2014
In the literature, several papers report studies on mathematical models used to describe facial features and to predict female facial beauty based on 3D human face data. Many authors have proposed the principal component analysis (PCA) method that permits modeling of the entire human face using a limited number of ...
Stojadinovic Miroslav M MM Deparment of Urology, Clinic of Urology and Nephrology, Clinical Centre Kragujevac, Zmaj Jovina 30, 34 000, Kragujevac, Serbia, - - 2014
Karakiewicz et al. and Green et al. created pre-cystectomy nomograms to predict lymph node involvement. The aim of the study was to externally validate these two nomograms in intermediate-volume institutions in Europe. Data from a Serbian single-centre cystectomy series comprising 183 patients with bladder cancer were used for the validation ...
Albrecht Theresa T Plant Breeding, Center of Life and Food Sciences Weihenstephan, Technische Universität München, Liesel-Beckmann-Straße 2, 85354, Freising, - - 2014
The calibration data for genomic prediction should represent the full genetic spectrum of a breeding program. Data heterogeneity is minimized by connecting data sources through highly related test units. One of the major challenges of genome-enabled prediction in plant breeding lies in the optimum design of the population employed in ...
Wilbaux Mélanie M EMR 3738, Ciblage Thérapeutique en Oncologie, Faculté de Médecine et de Maïeutique Lyon-Sud Charles Mérieux, Université Claude Bernard Lyon 1, Oullins, France. Electronic address: - - 2014
Early prediction of the expected benefit of treatment in recurrent ovarian cancer (ROC) patients may help in drug development decisions. The actual value of 50% CA-125 decrease is being reconsidered. The main objective of the present study was to quantify the links between longitudinal assessments of CA-125 kinetics and progression-free ...
Flood Ann Barry AB Geisel School of Medicine at Dartmouth, EPR Center, Hanover, NH 03768, - - 2014
Planning and preparation for a large-scale nuclear event would be advanced by assessing the applicability of potentially available bio-dosimetry methods. Using an updated comparative framework the performance of six bio-dosimetry methods was compared for five different population sizes (100-1 000 000) and two rates for initiating processing of the marker ...
Li Rui R Pharmacokinetics, Dynamics, and Metabolism, Pfizer Worldwide R&D, Cambridge, MA, - - 2014
Physiologically based pharmacokinetic (PBPK) models provide a framework useful for generating credible human pharmacokinetic predictions from data available at the earliest, preclinical stages of pharmaceutical research. With this approach, the pharmacokinetic implications of in vitro data are contextualized via scaling according to independent physiological information. However, in many cases these ...
Aharoni Eyal E a RAND Corporation , Santa Monica , CA , - - 2014
A recently published study by the present authors reported evidence that functional changes in the anterior cingulate cortex within a sample of 96 criminal offenders who were engaged in a Go/No-Go impulse control task significantly predicted their rearrest following release from prison. In an extended analysis, we use discrimination and ...
Ghosh Manik Kumer - - 2014
New theoretical procedures were proposed for the heats of vaporization (∆H_vap) and sublimation (∆H_sub)predictions by adopting Effective Fragment Potential Version 2-Molecular Dynamics (EFP2-MD) simulations. The particular EFP2 as generated by HF/6-31++G(2d,2p) yielded excellent results in the predictions of ∆H_vap, where mean absolute deviation (MAD) and root mean square deviation (RMSD) ...
Hohwy Jakob J a Cognition & Philosophy Lab , Monash University , Melbourne , - - 2014
Abstract Seth's counterfactual-based predictive processing account of presence is compelling and innovative; it gives a new, deeper understanding of a critical aspect of our phenomenology. Remaining in overall agreement with Seth's use of the prediction error minimization framework, I consider the elusive concept of presence, I probe the exact role ...
Amstadter Ananda B AB Ananda B. Amstadter, PhD, John M. Myers, MS, Department of Psychiatry, Virginia Institute of Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia; Kenneth S. Kendler, MD, Department of Psychiatry, Virginia Institute of Psychiatric and Behavioral Genetics, and Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, Virginia, - - 2014
The source of variability in people's response to stressful life events is poorly understood. We examine the genetic and environmental underpinning of resilience (i.e. the difference between the twins' internalising symptoms and their predicted symptoms based on cumulative stressful life events). Stressful life event exposure and internalising symptoms were assessed ...
Richards Adam J AJ Department of Biostatistics & Bioinformatics, Duke University, Durham, NC, USA; Duke Center for AIDS Research, Duke University, Durham, NC, USA; Duke External Quality Assurance Program Oversight Laboratory, Duke University, Durham, NC, USA. Electronic address: - - 2014
The accurate identification of rare antigen-specific cytokine positive cells from peripheral blood mononuclear cells (PBMC) after antigenic stimulation in an intracellular staining (ICS) flow cytometry assay is challenging, as cytokine positive events may be fairly diffusely distributed and lack an obvious separation from the negative population. Traditionally, the approach by ...
Sahigara Faizan - - 2014
Several classical and two recently proposed Applicability Domain (AD) approaches were implemented on a set of three classification models retrieved from a published study to assess the ready biodegradability of chemicals. Each model was associated with an optimal AD approa¬ch based on its ability to a) retain maximum test molecules ...
Martín Nirian N Department of Statistics, Carlos III University of Madrid, - - 2014
The previously unknown asymptotic distribution of Cook's distance in polytomous logistic regression is established as a linear combination of independent chi-square random variables with one degree of freedom. An exhaustive approach to the analysis of influential covariates is developed and a new measure for the accuracy of predictions based on ...
Khan Kamran A KA Warwick Clinical Trials Unit, Division of Health Sciences, Warwick Medical School, University of Warwick, Coventry, CV4 7AL, UK, - - 2014
The Pediatric Quality of Life Inventory™ (PedsQL™) General Core Scales (GCS) were designed to provide a modular approach to measuring health-related quality of life in healthy children, as well as those with acute and chronic health conditions, across the broadest, empirically feasible, age groups (2-18 years). Currently, it is not possible ...
Achary P G R PG a Department of Chemistry , Institute of Technical Education and Research (ITER), Siksha 'O' Anusandhan University , Bhubaneswar , Odisha , - - 2014
Simplified molecular input line entry system (SMILES) notations of 116 π-conjugated organic compounds have been used in three random splits to develop single optimal descriptor based quantitative structure-property relationships (QSPR) models for the prediction of dielectric constants by CORAL (CORrelation And Logic). Four kinds of optimal descriptors were obtained based ...
Xanthakis Vanessa V Framingham Heart Study, Framingham, MA, U.S.A.; Department of Biostatistics, Boston University School of Public Health, Boston, MA, U.S.A.; Section of Preventive Medicine and Epidemiology, Boston University School of Medicine, Boston, MA, - - 2014
It is unclear to what extent the incremental predictive performance of a novel biomarker is impacted by the method used to control for standard predictors. We investigated whether adding a biomarker to a model with a published risk score overestimates its incremental performance as compared to adding it to a ...
Enger Tone Bull - - 2014
Veno-venous extracorporeal membrane oxygenation (vvECMO) can be a life-saving therapy in patients with severe acute lung failure refractory to conventional therapy. Nevertheless, vvECMO is a procedure associated with high costs and resource utilization. The aim of this study was to assess published models for prediction of mortality following vvECMO and ...
Eleveld Douglas J DJ From the *Department of Anesthesiology, University Medical Center Groningen, University of Groningen, The Netherlands; †Departmento de Anestesiología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile; and ‡Department of Anesthesia, Ghent University, Gent, - - 2014
Pharmacokinetic (PK) models are used to predict drug concentrations for infusion regimens for intraoperative displays and to calculate infusion rates in target-controlled infusion systems. For propofol, the PK models available in the literature were mostly developed from particular patient groups or anesthetic techniques, and there is uncertainty of the accuracy ...
Marella William M WM From the Pennsylvania Patient Safety Authority, Harrisburg, Pennsylvania; and ECRI Institute, Plymouth Meeting, - - 2014
The objective of this study was to develop a semiautomated approach to screening cases that describe hazards associated with the electronic health record (EHR) from a mandatory, population-based patient safety reporting system. Potentially relevant cases were identified through a query of the Pennsylvania Patient Safety Reporting System. A random sample ...
Harsa Alexandra M - - 2014
Quantitative Structure-Activity Relationships based on molecular descriptors calculated with correlation weights within the hypermolecule, considered to mimic the investigated correlational space, was performed on a set of 40 flavonoids (PubChem database). The best models describing log P and LD50 of this set of flavonoids were validated by the leave-one-out procedure, ...
Gómez-Losada Alvaro A Environmental and Water Agency of Andalusia, c/Johan G. Gutemberg s/n, Isla de la Cartuja 41092 Seville, Spain; Department of Statistics and Operational Research, University of Seville, Avda. Reina Mercedes s/n, Seville, Spain. Electronic address: - - 2014
Existing air quality monitoring programs are, on occasion, not updated according to local, varying conditions and as such the monitoring programs become non-informative over time, under-detecting new sources of pollutants or duplicating information. Furthermore, inadequate maintenance may cause the monitoring equipment to be utterly deficient in providing information. To deal ...
Huang Chun-Wei CW Department of Bioenvironmental Systems Engineering, National Taiwan University, Taipei 10617, Taiwan, - - 2014
This study develops a procedure that is related to Generalized Likelihood Uncertainty Estimation (GLUE), called the CV-GLUE procedure, for assessing the predictive uncertainty that is associated with different model structures with varying degrees of complexity. The proposed procedure comprises model calibration, validation, and predictive uncertainty estimation in terms of a ...
Williams Benjamin B BB Department of Radiology, EPR Center for the Study of Viable Systems, Geisel School of Medicine at Dartmouth, Hanover, NH, USA, - - 2014
The management of radiation injuries following a catastrophic event where large numbers of people may have been exposed to life-threatening doses of ionizing radiation will rely critically on the availability and use of suitable biodosimetry methods. In vivo electron paramagnetic resonance (EPR) tooth dosimetry has a number of valuable and ...
Rose Johnie - - 2014
Approximately one-third of those treated curatively for colorectal cancer (CRC) will experience recurrence. No evidence-based consensus exists on how best to follow patients after initial treatment to detect asymptomatic recurrence. Here, a new approach for simulating surveillance and recurrence among CRC survivors is outlined, and development and calibration of a ...
White Ryen W RW Microsoft Research, Redmond, - - 2014
The promise of augmenting pharmacovigilance with patient-generated data drawn from the Internet was called out by a scientific committee charged with conducting a review of FDA's current and planned pharmacovigilance practices. To this end, we present a study on harnessing behavioral data drawn from Internet search logs to detect adverse ...
Pixley Jocelyn J Department of Sociology, Macquarie University and the IRRS, University of New South - - 2014
Economic theories of uncertainty are unpopular with financial experts. As sociologists, we rightly refuse predictions, but the uncertainties of money are constantly sifted and turned into semi-denial by a financial economics set on somehow beating the future. Picking out 'bits' of the future as 'risk' and 'parts' as 'information' is ...
Slight Sarah P SP 1The Center for Patient Safety Research and Practice, Division of General Internal Medicine, Brigham and Women's Hospital, Boston, MA. 2School of Medicine, Pharmacy and Health, The University of Durham, Durham, United Kingdom. 3Eastern Research Group, Inc., Lexington, MA. 4California Hospital Medical Center and David Geffen School of Medicine, UCLA, Los Angeles, CA. 5Harvard Medical School, Boston, MA. 6The Chaim Sheba Medical Center, Tel Hashomer, - - 2014
To evaluate the cost savings attributable to the implementation of a continuous monitoring system in a medical-surgical unit and to determine the return on investment associated with its implementation. Return on investment analysis. A 316-bed community hospital. Medicine, surgery, or trauma patients admitted or transferred to a 33-bed medical-surgical unit. ...
Tayob Nabihah N Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, - - 2014
Terminal events are commonly combined with other outcomes to improve the power for detecting treatment effects in clinical studies. This manuscript explores novel ways to combine information on terminal and recurrent events in constructing two-sample tests. Existing approaches follow either a time-to-first event analysis approach or a recurrent event modeling ...
Sharma Ajeet D AD aDepartment of Cardiac Anesthesia/Cardiac Surgery, St Vincent Hospital Heart Center, Green Bay, Wisconsin bDepartment of Pharmaceutical Sciences, Campbell University, Buies Creek, North Carolina, - - 2014
Cardiopulmonary bypass (CPB) coagulopathy increases utilization of allogenic blood/blood products, which can negatively affect patient outcomes. Thromboelastography (TEG) is a point-of-care measurement of clot formation and fibrinolysis. We investigated whether the addition of TEG parameters to a clinically based bleeding model would improve the predictability of postoperative bleeding. A total ...
Niedzwiedz Claire C Institute of Health and Wellbeing, University of Glasgow, Glasgow, - - 2014
Suicide clusters are a rare and underresearched phenomenon which attract wide media attention and result in heightened concern in the communities where they occur. We conducted a systematic literature review covering the definition and epidemiology of the time-space clustering of suicidal behavior. Of the 890 articles identified by electronic searching, ...
Böhnke Jan R JR University of York, York, - - 2014
The need for efficient clinical assessment instruments has been growing during the past years. In the current application, the item information (item response theory) is used to evaluate and build fixed short versions. The method was applied to a questionnaire measuring psychological distress and data were collected from two mixed ...
Vispoel Walter P - - 2014
Item response theory (IRT) models were applied to dichotomous and polytomous scoring of the Self-Deceptive Enhancement and Impression Management subscales of the Balanced Inventory of Desirable Responding (Paulhus, 1991, 1999). Two dichotomous scoring methods reflecting exaggerated endorsement and exaggerated denial of socially desirable behaviors were examined. The 1- and 2-parameter ...
Wolbers Marcel M Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Ho Chi Minh City, - - 2014
Studies in cardiology often record the time to multiple disease events such as death, myocardial infarction, or hospitalization. Competing risks methods allow for the analysis of the time to the first observed event and the type of the first event. They are also relevant if the time to a specific ...
Huang Kuo-Chang - - 2014
The first mock jury study in Taiwan, in which 279 community members watched a videotaped trial, investigated how jurors' estimates of the relative undesirability of wrongful conviction versus wrongful acquittal predicted individual decisions and how decision rules affected outcomes. The percentage of jurors who viewed wrongful conviction as more undesirable ...
Froggett Stephan J - - 2014
Advances in adding nanomaterials to various matrices have occurred in tandem with the identification of potential hazards associated with exposure to pure forms of nanomaterials. We searched multiple research publication databases and found that, relative to data generated on potential nanomaterial hazards or exposures, very little attention has focused on ...
Tuleau-Malot Christine C Université Nice Sophia Antipolis, CNRS, LJAD, UMR 7351, 06100 Nice, France - - 2014
The unitary events (UE) method is one of the most popular and efficient methods used over the past decade to detect patterns of coincident joint spike activity among simultaneously recorded neurons. The detection of coincidences is usually based on binned coincidence count (Grün, 1996), which is known to be subject ...
Coenen Pieter P Research Institute MOVE, Faculty of Human Movement Sciences, VU University Amsterdam, Van der Boechorststraat 9, 1081BT Amsterdam, The Netherlands. Electronic address: - - 2014
Exposure to mechanical vibrations at work (e.g., due to handling powered tools) is a potential occupational risk as it may cause upper extremity complaints. However, reliable and valid assessment methods for vibration exposure at work are lacking. Measuring hand-arm vibration objectively is often difficult and expensive, while often used information ...
Shayanfar Ali A Drug Applied Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: - - 2014
The external validation of QSAR models is crucial to ensure their reliability for assessing new chemicals. The most widely used criteria for external validations, which has been applied in hundreds of more recent QSAR studies are the Golbraikh-Tropsha and Roy methods which these criteria are based on the regression through ...
Atkins Rahshida R 1Rutgers, The State University of New Jersey, Ewing, - - 2014
The aim of this study was to test a theoretical model of depression for Black single mothers. Participants were 208 Black single mothers, aged 18 to 45, recruited from community settings. The a priori over-identified recursive theoretical model was tested via the LISREL 9.1 program using a maximum likelihood estimation ...
Asadi Somayeh S Department of Civil and Architectural Engineering, Texas A&M University-Kingsville, MSC 194, 700 University Blvd, Kingsville, TX, 7836, USA, - - 2014
In recent years, the application of titanium dioxide (TiO2) as a photocatalyst in asphalt pavement has received considerable attention for purifying ambient air from traffic-emitted pollutants via photocatalytic processes. In order to control the increasing deterioration of ambient air quality, urgent and proper risk assessment tools are deemed necessary. However, ...
Carabini Louanne M LM Departments of *Anesthesiology ‡Anesthesiology & Neurological Surgery §Neurological Surgery ∥Anesthesiology, Neurology, & Neurological Surgery, Northwestern University Feinberg School of Medicine, Feinberg, Chicago, IL †Department of Anesthesia, American University of Beirut, Beirut, - - 2014
Surgery for posterior spine instrumentation often requires major transfusion. The aim of this study was to develop and test the validity of a model for predicting intraoperative major transfusion (>4 U total red blood cells), based on preoperative patient and surgical variables, that was applicable to adult patients undergoing cervical, ...
Abduljalil Khaled K Simcyp Ltd (a Certara Company), Blades Enterprise Centre, John Street, Sheffield, S2 4SU, - - 2014
Although both POPPK and physiologically based pharmacokinetic (PBPK) models can account for age and other covariates within a paediatric population, they generally do not account for real-time growth and maturation of the individuals through the time course of drug exposure; this may be significant in prolonged neonatal studies. The major ...
Bond Jason J Alcohol Research Group, Emeryville, CA, - - 2014
Although the relationship between the Y90 (blood alcohol concentration, BAC) and Y91 (clinician intoxication assessment) ICD-10 codes has received attention recently, the role of 10 signs of intoxication in the Y91-Y90 relationship has not been studied yet. This work examines these signs in the estimation of alcohol intoxication levels of ...
Poltavski Dmitri V DV Department of Psychology, University of North Dakota , Grand Forks, ND , USA - - 2014
Abstract Hypothesis/objective: The purpose of the present study was to determine the utility of oculomotor-based evaluation protocols in screening for lifetime concussion incidence in elite hockey players. Methods: Forty-two Division I collegiate male and female hockey players were evaluated using the guidelines of an overall oculomotor-based diagnostic clinical test protocol ...
1 2 3 4 5 6 7 8 9 10 >