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de Almeida John R JR Department of Otolaryngology-Head and Neck Surgery, Princess Margaret Hospital, Toronto, - - 2014
Background: The present study is an economic evaluation comparing TORS to (chemo)radiotherapy for the management of early T-classification oropharyngeal cancer. Methods: A societal perspective was adopted. Treatment for TORS and (chemo)radiotherapy were modeled using decision analysis and recurrences were modeled over a 10 year horizon with a Markov model. Model ...
Falk Carl F CF Graduate School of Education & Information Studies, University of California, Los Angeles (UCLA), Los Angeles, CA, 90095-1521 , USA, - - 2014
We present a semi-parametric approach to estimating item response functions (IRF) useful when the true IRF does not strictly follow commonly used functions. Our approach replaces the linear predictor of the generalized partial credit model with a monotonic polynomial. The model includes the regular generalized partial credit model at the ...
Diez Roux Ana V - - 2014
The simulation of complex systems has received increasing attention as a useful approach in epidemiology. As discussed by Marshall and Galea in this issue of the Journal (Am J Epidemiol. 2014;000(00):0000-0000), systems approaches are appealing because they allow explicit recognition of feedback, interference, adaptation over time, and nonlinearities. However, they ...
Zhao Dongbin - - 2014
In this paper, the first probably approximately correct (PAC) algorithm for continuous deterministic systems without relying on any system dynamics is proposed. It combines the state aggregation technique and the efficient exploration principle, and makes high utilization of online observed samples. We use a grid to partition the continuous state ...
Page Trevor T GEA Pharma Systems Ltd., Eastleigh, Hampshire, SO53 4ZD, - - 2014
This white paper focuses on equipment, and analytical manufacturers' perspectives, regarding the challenges of continuous pharmaceutical manufacturing across five prompt questions. In addition to valued input from several vendors, commentary was provided from experienced pharmaceutical representatives, who have installed various continuous platforms. Additionally, a small medium enterprise (SME) perspective was ...
Hoffmann Anna A Department of Optimization, Fraunhofer Institute for Industrial Mathematics (ITWM), Kaiserslautern, Germany. Electronic address: - - 2014
Mathematical models of chemotherapy planning problems contain various biomedical parameters, whose values are difficult to quantify and thus subject to some uncertainty. This uncertainty propagates into the therapy plans computed on these models, which poses the question of robustness to the expected therapy quality. This work introduces a combined approach ...
Sansom Robert S RS Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK; - - 2014
The utility of fossils in evolutionary contexts is dependent on their accurate placement in phylogenetic frameworks, yet intrinsic and widespread missing data make this problematic. The complex taphonomic processes occurring during fossilization can make it difficult to distinguish absence from non-preservation, especially in the case of exceptionally preserved soft-tissue fossils: ...
Venco Francesco - - 2014
Life-science laboratories make increasing use of Next Generation Sequencing (NGS) for studying bio-macromolecules and their interactions. Array-based methods for measuring gene expression or protein-DNA interactions are being replaced by RNA-Seq and ChIP-Seq. Sequencing is generally performed by specialized facilities that have to keep track of sequencing requests, trace samples, ensure ...
Poludniowski G G Centre for Vision Speech and Signal Processing, University of Surrey, Guildford, GU2 7XH, - - 2014
A novel approach to proton CT reconstruction using backprojection-then-filtering (BPF) is proposed. A list-mode algorithm is formulated accommodating non-linear proton paths. The analytical form is derived for the deblurring kernel necessary for the filtering step. Further, a finite matrix correction is derived to correct for the limited size of the ...
McGuire Alan B AB Roudebush VA Medical Center, Indianapolis, IN, USA, - - 2014
This study examined three methodological approaches to defining the critical elements of Illness Management and Recovery (IMR), a curriculum-based approach to recovery. Sixty-seven IMR experts rated the criticality of 16 IMR elements on three dimensions: defining, essential, and impactful. Three elements (Recovery Orientation, Goal Setting and Follow-up, and IMR Curriculum) ...
Baran Michael M M. Baran, PhD Candidate, School of Arts Media and Engineering, Arizona State University, PO Box 878709, Tempe, AZ 85287 - - 2014
Interactive neurorehabilitation (INR) systems provide therapy that can evaluate and deliver feedback on a patient's movement computationally. There are currently many approaches to INR design and implementation, without a clear indication of which methods to utilize best. We present key interactive computing, motor learning and media arts concepts utilized by ...
Liu Yan-Jun - - 2014
Based on the neural network (NN) approximator, an online reinforcement learning algorithm is proposed for a class of affine multiple input and multiple output (MIMO) nonlinear discrete-time systems with unknown functions and disturbances. In the design procedure, two networks are provided where one is an action network to generate an ...
Mainsah Boyla - - 2014
P300 spellers can provide a means of communication for individuals with severe neuromuscular limitations. However, its use as an effective communication tool is reliant on high P300 classification accuracies (>70%) to account for error revisions. Error-related potentials (ErrP), which are changes in EEG potentials when a person is aware of ...
Pinto M M IPNL, Université de Lyon, F-69003 Lyon, France; Université Lyon 1, F-69622 Villeurbanne, France; CNRS/IN2P3, UMR 5822 F-69622 Villeurbanne, - - 2014
Hadrontherapy is an innovative radiation therapy modality for which one of the main key advantages is the target conformality allowed by the physical properties of ion species. However, in order to maximise the exploitation of its potentialities, online monitoring is required in order to assert the treatment quality, namely monitoring ...
Watanabe Noriko - - 2014
Insecticide-treated nets (ITNs) are an integral piece of any malaria elimination strategy, but compliance remains a challenge and determinants of use vary by location and context. The Health Belief Model (HBM) is a tool to explore perceptions and beliefs about malaria and ITN use. Insights from the model can be ...
Li Qiuju Q School of Mathematics, The University of Manchester, - - 2014
In medical studies, repeated measurements of continuous, binary and ordinal outcomes are routinely collected from the same patient. Instead of modelling each outcome separately, in this study we propose to jointly model the trivariate longitudinal responses, so as to take account of the inherent association between the different outcomes and ...
Tronstad Lund Marianne - - 2014
Biofuels are proposed to play an important role in several mitigation strategies to meet future CO2 emission targets for the transport sector, but remain controversial due to significant uncertainties in net impacts on environment, society and climate. A switch to biofuels can also affect short-lived climate forcers (SLCFs), which provide ...
Bartolucci Chiara C Biomedical Engineering Laboratory D.E.I, University of Bologna, Cesena, - - 2014
In the present work Action-Potential clamp (APC) and Dynamic clamp (DC) were used in combination in order to optimize the Luo-Rudy (LRd) mathematical formulation of the guinea-pig rapid delayed rectifier K(+) current (IKr), and to validate the optimized model. To this end, IKr model parameters were adjusted to fit the ...
Hatano Takuma T Graduate School of Information Science and Technology, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan. Electronic address: - - 2014
Mathematical modelling is essential for personalizing intermittent androgen suppression, which was proposed to delay the relapse of prostate cancer by stopping and resuming the hormone therapy repeatedly than adopting the conventional continuous androgen suppression, or normal hormonal therapy. Although there are several mathematical models for intermittent androgen suppression, the performances ...
Wu Jinglan J State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing, 210009, P. R. China; College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, 210009, P. R. China; National Engineering Technique Research Center for Biotechnology, Nanjing, 211816, P. R. - - 2014
Separation of butanol based on sorption methodology from Acetone - Butanol - Ethanol (ABE) fermentation broth has advantages in terms of biocompatibility and stability, as well as economy, and therefore gains much attention. In this work a chromatographic column model based on the solid film linear driving force approach and ...
Hwang Wen-Han WH Institute of Statistics and Department of Applied Mathematics, National Chung Hsing University, Taichung 40227, - - 2014
Good-Turing frequency estimation (Good, ) is a simple, effective method for predicting detection probabilities of objects of both observed and unobserved classes based on observed frequencies of classes in a sample. The method has been used widely in several disciplines, such as information retrieval, computational linguistics, text recognition, and ecological ...
Gan Sonny - - 2014
Spectral clustering involves placing objects into clusters based on the eigenvectors and eigenvalues of an associated matrix. The technique was first applied to molecular data by Brewer [J. Chem. Inf. Modell. 47,1727-1733 (2007)] who demonstrated its use on a very small dataset of 125 COX-2 inhibitors. We have determined suitable ...
Guelpa Anina A Department of Food Science, Stellenbosch University, Private Bag X1, Matieland (Stellenbosch) 7602, South Africa. Electronic address: - - 2015
It has been established in this study that the Rapid Visco Analyser (RVA) can describe maize hardness, irrespective of the RVA profile, when used in association with appropriate multivariate data analysis techniques. Therefore, the RVA can complement or replace current and/or conventional methods as a hardness descriptor. Hardness modelling based ...
Metyko John J *Department of Environmental Health and Safety, MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030-4009; †Department of Imaging Physics Department, MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX - - 2014
Three different Y internally-administered radionuclide therapies are currently used in both standard-of-care and clinical trial procedures at MD Anderson Cancer Center. TheraSphere and SIR-Spheres therapies utilize Y-labeled microspheres, while Zevalin is an Y-labeled radioimmunotherapeutic agent. Several publications have indicated radionuclidic impurities resulting from Y production methods. The Y in SIR-Spheres ...
Harding R R St James's Institute of Oncology, Medical Physics and Engineering, Leeds LS9 7TF, United Kingdomand Abertawe Bro Morgannwg University Health Board, Medical Physics and Clinical Engineering, Swansea SA2 8QA, United - - 2014
Base of skull meningioma can be treated with both intensity modulated radiation therapy (IMRT) and spot scanned proton therapy (PT). One of the main benefits of PT is better sparing of organs at risk, but due to the physical and dosimetric characteristics of protons, spot scanned PT can be more ...
Wang Liangsu L Merck Research Laboratories, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA. Electronic address: - - 2014
The pharmaceutical industry continues to face fundamental challenges because of issues with research and development (R&D) productivity and rising customer expectations. To lower R&D costs, move beyond me-too therapies, and create more transformative portfolios, pharmaceutical companies are actively capitalizing on external innovation through precompetitive collaboration with academia, cultivation of biotech ...
De Bin Riccardo - - 2014
In the last years, the importance of independent validation of the prediction ability of a new gene signature has been largely recognized. Recently, with the development of gene signatures which integrate rather than replace the clinical predictors in the prediction rule, the focus has been moved to the validation of ...
Zhang Xinke X Department of Clinical Pharmacy and Pharmaceutical Economics and Policy, Leonard D. Schaeffer Center for Health Policy and Economics, University of Southern California, University Park Campus, VPD 214-L, Los Angeles, CA, 90089-3333, - - 2014
The aim of the study was to compare the cost effectiveness of fingolimod, teriflunomide, dimethyl fumarate, and intramuscular (IM) interferon (IFN)-β1a as first-line therapies in the treatment of patients with relapsing-remitting multiple sclerosis (RRMS). A Markov model was developed to evaluate the cost effectiveness of disease-modifying drugs (DMDs) from a ...
Amin Kawa K Care of Elderly Department, Queens Hospital, Barking, Havering and Redbridge NHS Trust, Broomfield Hospital at Chelmsford, Essex, UK. Electronic address: - - 2014
Addressing the needs to achieve the highest standards at multidisciplinary team meetings at the Stroke Unit of Broomfield Hospital, an electronic version is applied instead of the traditional paper model. This is to ensure that patients within the unit are receiving appropriate care and their progress is monitored throughout their ...
Hu En-Liang - - 2014
Nonparametric kernel learning (NPKL) is a flexible approach to learn the kernel matrix directly without assuming any parametric form. It can be naturally formulated as a semidefinite program (SDP), which, however, is not very scalable. To address this problem, we propose the combined use of low-rank approximation and block coordinate ...
Ditty Matthew S MS The Ebright Foundation, LLC, 2800 Lancaster Ave., Suite 6, Wilmington, DE, 19810, USA, - - 2014
Guided by the Consolidated Framework for Implementation Research, this mixed method study explored the relationship between inner setting variables and dialectical behavior therapy (DBT) implementation. Intensively trained DBT clinicians completed an online quantitative survey (n = 79) and a subset were sequentially interviewed using qualitative methods (n = 20) to identify relationships between inner ...
Kona Ravikanth R School of Pharmacy, University of Maryland, 20 N. Pine Street, Baltimore, Maryland, 21201, - - 2014
The objective of this study is to use near-infrared spectroscopy (NIRS) coupled with multivariate chemometric models to monitor granule and tablet quality attributes in the formulation development and manufacturing of ciprofloxacin hydrochloride (CIP) immediate release tablets. Critical roller compaction process parameters, compression force (CFt), and formulation variables identified from our ...
Nascimento Jacinto - - 2014
This paper proposes an iterative natural gradient algorithm to perform the optimization of switching probabilities in a space-varying HMM, in the context of human activity recognition in long-range surveillance. The proposed method is a version of the gradient method, developed under an information geometric viewpoint, where the usual Euclidean metric ...
Simundic Ana-Maria - - 2014
Abstract At least one in 10 patients experience adverse events while receiving hospital care. Many of the errors are related to laboratory diagnostics. Efforts to reduce laboratory errors over recent decades have primarily focused on the measurement process while pre- and post-analytical errors including errors in sampling, reporting and decision-making ...
Elliott Douglas C DC Pacific Northwest National Laboratory, P.O. Box 999, Richland, WA 99352, - - 2014
This review describes the recent results in hydrothermal liquefaction (HTL) of biomass in continuous-flow processing systems. Although much has been published about batch reactor tests of biomass HTL, there is only limited information yet available on continuous-flow tests, which can provide a more reasonable basis for process design and scale-up ...
Lee Xing Ju XJ School of Mathematical Sciences, Queensland University of Technology, Brisbane, Queensland, 4000, - - 2014
Analytically or computationally intractable likelihood functions can arise in complex statistical inferential problems making them inaccessible to standard Bayesian inferential methods. Approximate Bayesian computation (ABC) methods address such inferential problems by replacing direct likelihood evaluations with repeated sampling from the model. ABC methods have been predominantly applied to parameter estimation ...
Carson-Wong Amanda A a Department of Psychology , Rutgers University , Piscataway , NJ , - - 2014
Abstract Objective: There are six strategies or validation levels in dialectical behavior therapy (DBT), yet there are no measures designed to code for them. This absence limits our understanding of the relationship between validation strategies and treatment outcome. The DBT-Validation Level Coding Scale (DBT-VLCS) was developed to overcome this limitation. ...
Martin Johannes J E JJ MARTIN GmbH für Umwelt- und Energietechnik, Leopoldstrasse 248, 80807 München, - - 2014
Thermal treatment of waste by means of combustion in grate-based systems has gained world-wide acceptance as the preferred method for sustainable management and safe disposal of residual waste. In order to maintain this position and to address new challenges and/or priorities, these systems need to be further developed with a ...
Ament Jared D JD University of California, Davis, - - 2014
Cervical total disc replacement (CTDR) was developed to treat cervical spondylosis, while preserving motion. While anterior cervical discectomy and fusion (ACDF) has been the standard of care for 2-level disease, a randomized clinical trial (RCT) suggested similar outcomes. Cost-effectiveness of this intervention has never been elucidated. To determine the cost-effectiveness ...
Murray Carolyn C School of Health Sciences, International Centre for Allied Health Evidence, University of South Australia, Adelaide, South Australia, - - 2014
Growth in the number of occupational therapy programmes in Australia has resulted in a critical shortage of academics. When experienced clinicians are recruited into academia, they may find the transition process difficult. The study aimed to explore clinicians' perspectives of what happens when they transition into academia. A constructivist grounded ...
Biswas Subhodip - - 2014
In real life, we often need to find multiple optimally sustainable solutions of an optimization problem. Evolutionary multimodal optimization algorithms can be very helpful in such cases. They detect and maintain multiple optimal solutions during the run by incorporating specialized niching operations in their actual framework. Differential evolution (DE) is ...
Hummert Sabine S Fachhochschule Schmalkalden, Faculty of Electrical Engineering, Blechhammer, 98574 Schmalkalden, - - 2014
In two papers we review game theory applications in biology below the level of cognitive living beings. It can be seen that evolution and natural selection replace the rationality of the actors appropriately. Even in these micro worlds, competing situations and cooperative relationships can be found and modeled by evolutionary ...
Tindall B J BJ Leibniz Institute-DSMZ Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH., Inhoffenstrasse 7b, 38124 Braunschweig, Germany - - 2014
The Judicial Commission affirms that the COMBINATION: Micromonospora aurantiaca Sveshnikova et al. 1969 (Approved Lists 1980) may not serve as the CORRECT NAME: of the taxon because Rule 12b states that no SPECIFIC: or SUBSPECIFIC EPITHETS: within the same genus may be the same if based on different types and ...
Rafei Rayane R L'UNAM Université, Université d'Angers, Groupe d'Etude des Interactions Hôte-Pathogène, UPRES EA3142, Institut de Biologie en Santé - IRIS, CHU, 4, rue Larrey, 49933 Angers cedex, - - 2014
ABSTRACT  The emergence of Acinetobacter baumannii during recent decades as an important nosocomial pathogen responsible of worldwide, intensively documented, outbreaks has resulted in a need for effective epidemiological typing methods. Throughout the years, many typing methods for A. baumannii epidemiological studies have been proposed from phenotypic to molecular methods. Currently, ...
Li Bo B State Key Laboratory of Urban and Regional Ecology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Shuangqing Road 18, Haidian District, Beijing 100085, - - 2014
Due to the rapid development of economy and technology, China has the biggest production and possession of mobile phones around the world. In general, mobile phones have relatively short life time because the majority of users replace their mobile phones frequently. Retired mobile phones represent the most valuable electrical and ...
Yao Deqiang D Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, People's Republic of - - 2014
A case study has been made on the treatment of the SIRAS (single isomorphous replacement with anomalous scattering) data of the originally unknown protein LegC3N. An alternative treatment has been proposed which led to improved results in this particular test case. The treatment involves iterative direct-method SAD (single-wavelength anomalous diffraction) ...
Seki Motohide M Faculty of Environmental Earth Science, Hokkaido University, N10W5, Kita-ku, Sapporo, Hokkaido, 060-0810, Japan, - - 2014
According to the viewpoint of the optimal strategy theory, a tree is expected to shed its leaves when they no longer contribute to maximisation of net carbon gain. Several theoretical models have been proposed in which a tree was assumed to strategically shed an old deteriorated leaf to develop a ...
Albano Giuseppina G Dip. di Scienze Economiche e Statistiche, Università di Salerno, Italy. Electronic address: - - 2014
A modified Gompertz diffusion process is considered to model tumor dynamics. The infinitesimal mean of this process includes non-homogeneous terms describing the effect of therapy treatments able to modify the natural growth rate of the process. Specifically, therapies with an effect on cell growth and/or cell death are assumed to ...
Cerveri Pietro P Department of Electronics, Information and Bioengineering, Politecnico di Milano, via Ponzio 34/5, 20133 Milano, Italy. Electronic address: - - 2014
Personalized resection guides (PRG) have been recently proposed in the domain of knee replacement, demonstrating clinical outcome similar or even superior to both manual and navigated interventions. Among the mandatory pre-surgical steps for PRG prototyping, the measurement of clinical landmarks (CL) on the bony surfaces is recognized as a key ...
Ternès Nils N aService biostatistique et épidémiologie, Gustave-Roussy, Villejuif, bUniversity Paris-Sud, Le Kremlin-Bicêtre cDépartement de médecine, Pathologie Mammaire, Gustave-Roussy, Villejuif, - - 2014
Omics technologies have become an essential part of clinical trials in oncology to provide a better understanding of molecular mechanisms and to unveil therapeutic targets. Standard statistical methods often fail in the high-dimensional setting. Therefore, an adequate modelling of the omics data is needed in order to identify 'target' genes ...
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